Basic Information:

  VIRBase ID:  

HHID00003077

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-29b-3p:  MIMAT0000100          STK38L:  NM_015000     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-29b-3p	STK38L
miRBase Accession/Entrez ID	MIMAT0000100	23012
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	NDR2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-29b-3p	rs868994683 chr7:130877473    G/A rs1390817128 chr1:207802451    A/G rs773555186 chr1:207802453    A/C rs773555186 chr1:207802453    A/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	STK38L	chr12:27465011(+) A-I      intronic chr12:27464952(+) A-I      intronic chr12:27464913(+) A-I      intronic chr12:27428410(+) A-I      intronic chr12:27467187(+) A-I      intronic chr12:27467223(+) A-I      intronic chr12:27466501(+) A-I      intronic chr12:27467245(+) A-I      intronic chr12:27467255(+) A-I      intronic chr12:27424813(+) A-I      intronic chr12:27426941(+) A-I      intronic chr12:27465965(+) A-I      intronic chr12:27427065(+) A-I      intronic chr12:27428346(+) A-I      intronic chr12:27428377(+) A-I      intronic chr12:27428396(+) A-I      intronic chr12:27454317(+) A-I      intronic chr12:27454318(+) A-I      intronic chr12:27454321(+) A-I      intronic chr12:27427059(+) A-I      intronic chr12:27454322(+) A-I      intronic chr12:27454394(+) A-I      intronic chr12:27454400(+) A-I      intronic chr12:27454405(+) A-I      intronic chr12:27454454(+) A-I      intronic chr12:27455734(+) A-I      intronic chr12:27455784(+) A-I      intronic chr12:27455803(+) A-I      intronic chr12:27455839(+) A-I      intronic chr12:27456931(+) A-I      intronic chr12:27456993(+) A-I      intronic chr12:27465927(+) A-I      intronic chr12:27466030(+) A-I      intronic chr12:27466536(+) A-I      intronic chr12:27466551(+) A-I      intronic chr12:27467079(+) A-I      intronic chr12:27467105(+) A-I      intronic chr12:27467109(+) A-I      intronic chr12:27467120(+) A-I      intronic chr12:27467148(+) A-I      intronic chr12:27415985(+) A-I      intronic chr12:27415534(+) A-I      intronic chr12:27467299(+) A-I      intronic chr12:27467305(+) A-I      intronic chr12:27415540(+) A-I      intronic chr12:27415571(+) A-I      intronic chr12:27415633(+) A-I      intronic chr12:27415763(+) A-I      intronic chr12:27415871(+) A-I      intronic chr12:27415958(+) A-I      intronic chr12:27466389(+) A-I      intronic chr12:27422715(+) A-I      intronic chr12:27422845(+) A-I      intronic chr12:27422856(+) A-I      intronic chr12:27423540(+) A-I      intronic chr12:27424694(+) A-I      intronic chr12:27424762(+) A-I      intronic chr12:27424772(+) A-I      intronic chr12:27465997(+) A-I      intronic chr12:27428453(+) A-I      intronic chr12:27466392(+) A-I      intronic chr12:27440132(+) A-I      intronic chr12:27441067(+) A-I      intronic chr12:27466358(+) A-I      intronic chr12:27457107(+) A-I      intronic chr12:27459861(+) A-I      intronic chr12:27447203(+) A-I      intronic chr12:27415831(+) A-I      intronic chr12:27466018(+) A-I      intronic chr12:27466060(+) A-I      intronic chr12:27415836(+) A-I      intronic chr12:27451200(+) A-I      intronic chr12:27415511(+) A-I      intronic chr12:27440998(+) A-I      intronic chr12:27466464(+) A-I      intronic chr12:27447768(+) A-I      intronic chr12:27455685(+) A-I      intronic chr12:27447773(+) A-I      intronic chr12:27457013(+) A-I      intronic chr12:27428456(+) A-I      intronic chr12:27454331(+) A-I      intronic chr12:27415817(+) A-I      intronic chr12:27466590(+) A-I      intronic chr12:27457007(+) A-I      intronic chr12:27466454(+) A-I      intronic chr12:27451265(+) A-I      intronic chr12:27451133(+) A-I      intronic chr12:27447901(+) A-I      intronic chr12:27466499(+) A-I      intronic chr12:27415531(+) A-I      intronic chr12:27467133(+) A-I      intronic chr12:27415587(+) A-I      intronic chr12:27447365(+) A-I      intronic chr12:27466481(+) A-I      intronic chr12:27451261(+) A-I      intronic chr12:27465918(+) A-I      intronic chr12:27466513(+) A-I      intronic chr12:27473261(+) A-I      intronic chr12:27467213(+) A-I      intronic chr12:27424822(+) A-I      intronic chr12:27420300(+) A-I      intronic chr12:27428452(+) A-I      intronic chr12:27415783(+) A-I      intronic chr12:27459864(+) A-I      intronic chr12:27422797(+) A-I      intronic chr12:27466027(+) A-I      intronic chr12:27415832(+) A-I      intronic chr12:27466480(+) A-I      intronic chr12:27403785(+) A-I      intronic chr12:27447710(+) A-I      intronic chr12:27464877(+) A-I      intronic chr12:27456933(+) A-I      intronic chr12:27457112(+) A-I      intronic chr12:27466588(+) A-I      intronic chr12:27466021(+) A-I      intronic chr12:27454461(+) A-I      intronic chr12:27428381(+) A-I      intronic chr12:27415563(+) A-I      intronic chr12:27447877(+) A-I      intronic chr12:27428546(+) A-I      intronic chr12:27457017(+) A-I      intronic chr12:27467259(+) A-I      intronic chr12:27464997(+) A-I      intronic chr12:27467244(+) A-I      intronic chr12:27415553(+) A-I      intronic chr12:27459774(+) A-I      intronic chr12:27466319(+) A-I      intronic chr12:27467275(+) A-I      intronic chr12:27415782(+) A-I      intronic chr12:27447191(+) A-I      intronic chr12:27467100(+) A-I      intronic chr12:27424816(+) A-I      intronic chr12:27451146(+) A-I      intronic chr12:27466568(+) A-I      intronic chr12:27451225(+) A-I      intronic chr12:27466444(+) A-I      intronic chr12:27466070(+) A-I      intronic chr12:27459697(+) A-I      intronic chr12:27466456(+) A-I      intronic chr12:27451330(+) A-I      intronic chr12:27415495(+) A-I      intronic chr12:27447180(+) A-I      intronic chr12:27466126(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	STK38L	chr12:27451133(+) A-I intron -    15258596 chr12:27451146(+) A-I intron -    15258596 chr12:27451200(+) A-I intron -    15258596 chr12:27476394(+) T-G intron -    21725310 chr12:27478128(+) A-C intron -    21725310 chr12:27415563(+) A-G intron -    22484847 chr12:27466027(+) A-G intron -    22484847 chr12:27466060(+) A-G intron -    22484847 chr12:27466126(+) A-G intron -    22484847 chr12:27466358(+) A-G intron -    22484847 chr12:27466454(+) A-G intron -    22484847 chr12:27467259(+) A-G intron -    22484847 chr12:27467275(+) A-G intron -    22484847 chr12:27400768(+) G-T intron -    22484847 chr12:27403785(+) A-G intron -    22484847 chr12:27403950(+) G-A intron -    22484847 chr12:27415495(+) A-G intron -    22484847 chr12:27415511(+) A-G intron -    22484847 chr12:27415531(+) A-G intron -    22484847 chr12:27415553(+) A-G intron -    22484847 chr12:27415587(+) A-G intron -    22484847 chr12:27415783(+) A-G intron -    22484847 chr12:27415817(+) A-G intron -    22484847 chr12:27415831(+) A-G intron -    22484847 chr12:27415832(+) A-G intron -    22484847 chr12:27415877(+) G-A intron -    22484847 chr12:27422797(+) A-G intron -    22484847 chr12:27424816(+) A-G intron -    22484847 chr12:27424822(+) A-G intron -    22484847 chr12:27426943(+) C-T intron -    22484847 chr12:27428452(+) A-G intron -    22484847 chr12:27428453(+) A-G intron -    22484847 chr12:27428456(+) A-G intron -    22484847 chr12:27447174(+) T-C intron -    22484847 chr12:27447180(+) A-G intron -    22484847 chr12:27447203(+) A-G intron -    22484847 chr12:27447365(+) A-G intron -    22484847 chr12:27447901(+) A-G intron -    22484847 chr12:27451225(+) A-G intron -    22484847 chr12:27451265(+) A-G intron -    22484847 chr12:27454331(+) A-G intron -    22484847 chr12:27454461(+) A-G intron -    22484847 chr12:27459692(+) T-A intron -    22484847 chr12:27464877(+) A-G intron -    22484847 chr12:27464997(+) A-G intron -    22484847 chr12:27465918(+) A-G intron -    22484847 chr12:27465992(+) T-C intron -    22484847 chr12:27465997(+) A-G intron -    22484847 chr12:27466018(+) A-G intron -    22484847 chr12:27466021(+) A-G intron -    22484847 chr12:27466070(+) A-G intron -    22484847 chr12:27466392(+) A-G intron -    22484847 chr12:27466456(+) A-G intron -    22484847 chr12:27466464(+) A-G intron -    22484847 chr12:27466481(+) A-G intron -    22484847 chr12:27466499(+) A-G intron -    22484847 chr12:27466513(+) A-G intron -    22484847 chr12:27466568(+) A-G intron -    22484847 chr12:27467244(+) A-G intron -    22484847 chr12:27467353(+) G-A intron -    22484847 chr12:27471752(+) G-A intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	STK38L	chr12:27450782-27450783(+) m6A CDS//exon       24981863 chr12:27450808-27450809(+) m6A exon//intron       24981863 chr12:27450853-27450854(+) m6A exon//intron       24981863 chr12:27461307-27461308(+) m6A 3'UTR//CDS//intron       24981863 chr12:27461331-27461332(+) m6A 3'UTR//CDS//intron       24981863 chr12:27461336-27461337(+) m6A 3'UTR//CDS//intron       24981863 chr12:27470286-27470287(+) m6A 3'UTR//CDS       24981863 chr12:27470322-27470323(+) m6A 3'UTR//CDS       24981863 chr12:27470939-27470940(+) m6A 3'UTR//CDS//exon       24981863 chr12:27472280-27472281(+) m6A 3'UTR//CDS//exon       24981863 chr12:27475276-27475277(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085 chr12:27475281-27475282(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085 chr12:27475296-27475297(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085 chr12:27475419-27475420(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22608085 chr12:27475538-27475539(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085 chr12:27475637-27475638(+) m6A 3'UTR       24284625//24981863//22608085 chr12:27475712-27475713(+) m6A 3'UTR       24284625//24981863//22608085 chr12:27475742-27475743(+) m6A 3'UTR       24284625//24981863//22608085 chr12:27476030-27476031(+) m6A 3'UTR       27773535 chr12:27476550-27476551(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-29b-3p	Cytoplasm HeLa cells     28185889 Cytoplasm Hepatic carcinoma cells (Huh-7)     29253196 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Urine     26576778 Exosome HCC tissues     30542726 Exosome Saliva     19627513 Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Epithelial cells|Seminal fluid|Tongue tissue     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Hela cells|NIH-3T3 cells     17204650 Nucleus HeLa cells     28185889 Nucleus Hepatic carcinoma cells (Huh-7)     29253196 Nucleus HeLa cells     30006350 Nucleus Nasopharyngeal carcinoma cells     20498841
	STK38L	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-29b-3p	Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug resistant Phenyl gallate 333279 Drug resistant N-[(4R)-4-[(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Tris(3-aminopropoxy)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentyl]octan-1-amine 24205348 Drug sensitive 8-Hydroxyquinoline 1923 Drug resistant (R)-(2,8-Bis(trifluoromethyl)quinolin-4-yl)((S)-piperidin-2-yl)methanol hydrochloride 18660697 Drug sensitive Acid Alizarine Red B 135565636 Drug resistant 2-Acetylimidazo[4,5-b]pyridin 4 tolyl 3 thiosemicarbazone 135440014 Drug resistant 1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug resistant 4-carbo-1-thiazolidine-3-o-gluconyl-.gamma.-lactone - Drug resistant naphth[2,3-d]oxazol-9-one, 2-methyl-4-(phenylimino)- - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-29b-3p	Formaldehyde 712 Drug interaction    RC00001120 Oxaliplatine 6857599 Drug interaction    RC00001140 Gemcitabine 60750 Drug interaction    RC00001131 Progesterone 5994 Drug interaction    RC00001126 D-Glucose 5793 Drug interaction    RC00001125 Eloxatine 5310940 Drug interaction    RC00001139 Imatinib 5291 Drug interaction    RC00001124 Decitabine 451668 Drug interaction    RC00001137 Docosahexaenoic acid 445580 Drug interaction    RC00001136 Trichostatin A 444732 Drug interaction    RC00001135 Cyclopamine 442972 Drug interaction    RC00001134 Bortezomib 387447 Drug interaction    RC00001133 Etoposide 36462 Drug interaction    RC00001130 Paclitaxel 36314 Drug interaction    RC00001129 5-Fluorouracil 3385 Drug interaction    RC00001123 Enoxacin 3229 Drug interaction    RC00001122 Doxorubicin 31703 Drug interaction    RC00001128 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001121 Tamoxifen 2733526 Drug interaction    RC00001138 Ixazomib 25183872 Drug interaction    RC00001144 Navitoclax 24978538 Drug interaction    RC00001143 Ampligen & InterferonalphaA 16197265 Drug interaction    RC00001142 Leucovorin 135403648 Drug interaction    RC00001145 Ginsenoside Rh2 119307 Drug interaction    RC00001132 Carfilzomib 11556711 Drug interaction    RC00001141 Androstanolone 10635 Drug interaction    RC00001127 Chemotherapy - Drug interaction    RC00001146 5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00001147 Glucocorticoid - Drug interaction    RC00001148 Testosterone + 1,25-Dihydroxyvitamin D3 - Drug interaction    RC00001149 Trastuzumab - Drug interaction    RC00001150

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-29b-3p	Bortezomib 387447       30728351

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-29b-3p
Interactor2: STK38L

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).