Detail Information

Basic Information:


  VIRBase ID:  

HHID00003020

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-29b-3p:           CNOT8:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-29b-3p CNOT8
miRBase
Accession/Entrez ID		 MIMAT0000100 9337
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CAF1//Caf1b//CALIF//hCAF1//POP2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-29b-3p
rs868994683 chr7:130877473    G/A
rs1390817128 chr1:207802451    A/G
rs773555186 chr1:207802453    A/C
rs773555186 chr1:207802453    A/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CNOT8
chr5:154253873(+) A-I      intronic
chr5:154253882(+) A-I      intronic
chr5:154253908(+) A-I      intronic
chr5:154253909(+) A-I      intronic
chr5:154247721(+) A-I      intronic
chr5:154246362(+) A-I      intronic
chr5:154245848(+) A-I      intronic
chr5:154241987(+) A-I      intronic
chr5:154241903(+) A-I      intronic
chr5:154241883(+) A-I      intronic
chr5:154241457(+) A-I      intronic
chr5:154241395(+) A-I      intronic
chr5:154241359(+) A-I      intronic
chr5:154241358(+) A-I      intronic
chr5:154254331(+) A-I      intronic
chr5:154253927(+) A-I      intronic
chr5:154253993(+) A-I      intronic
chr5:154254009(+) A-I      intronic
chr5:154254042(+) A-I      intronic
chr5:154254043(+) A-I      intronic
chr5:154254051(+) A-I      intronic
chr5:154254169(+) A-I      intronic
chr5:154254198(+) A-I      intronic
chr5:154254657(+) A-I      intronic
chr5:154254219(+) A-I      intronic
chr5:154254259(+) A-I      intronic
chr5:154254280(+) A-I      intronic
chr5:154254292(+) A-I      intronic
chr5:154254295(+) A-I      intronic
chr5:154254304(+) A-I      intronic
chr5:154254317(+) A-I      intronic
chr5:154247708(+) A-I      intronic
chr5:154246366(+) A-I      intronic
chr5:154246423(+) A-I      intronic
chr5:154249205(+) A-I      intronic
chr5:154249302(+) A-I      intronic
chr5:154249310(+) A-I      intronic
chr5:154249311(+) A-I      intronic
chr5:154241339(+) A-I      intronic
chr5:154246352(+) A-I      intronic
chr5:154247517(+) A-I      intronic
chr5:154249906(+) A-I      intronic
chr5:154253875(+) A-I      intronic
chr5:154249368(+) A-I      intronic
chr5:154248034(+) A-I      intronic
chr5:154246455(+) A-I      intronic
chr5:154248022(+) A-I      intronic
chr5:154243926(+) A-I      intronic
chr5:154243102(+) A-I      intronic
chr5:154246353(+) A-I      intronic
chr5:154253976(+) A-I      intronic
chr5:154254199(+) A-I      intronic
chr5:154241845(+) A-I      intronic
chr5:154241909(+) A-I      intronic
chr5:154254223(+) A-I      intronic
chr5:154241465(+) A-I      intronic
chr5:154254616(+) A-I      intronic
chr5:154248063(+) A-I      intronic
chr5:154253980(+) A-I      intronic
chr5:154244530(+) A-I      intronic
chr5:154241440(+) A-I      intronic
chr5:154245847(+) A-I      intronic
chr5:154240051(+) A-I      intronic
chr5:154254729(+) A-I      intronic
chr5:154245786(+) A-I      intronic
chr5:154241520(+) A-I      intronic
chr5:154253881(+) A-I      intronic
chr5:154243064(+) A-I      intronic
chr5:154244375(+) A-I      intronic
chr5:154243870(+) A-I      intronic
chr5:154249444(+) A-I      intronic
chr5:154254622(+) A-I      intronic
chr5:154245861(+) A-I      intronic
chr5:154241816(+) A-I      intronic
chr5:154244494(+) A-I      intronic
chr5:154246215(+) A-I      intronic
chr5:154241443(+) A-I      intronic
chr5:154249502(+) A-I      intronic
chr5:154246388(+) A-I      intronic
chr5:154250861(+) A-I      intronic
chr5:154241416(+) A-I      intronic
chr5:154241445(+) A-I      intronic
chr5:154241919(+) A-I      intronic
chr5:154254015(+) A-I      intronic
chr5:154249904(+) A-I      intronic
chr5:154245851(+) A-I      intronic
chr5:154254355(+) A-I      intronic
chr5:154250999(+) A-I      intronic
chr5:154249737(+) A-I      intronic
chr5:154243873(+) A-I      intronic
chr5:154249570(+) A-I      intronic
chr5:154253989(+) A-I      intronic
chr5:154254739(+) A-I      intronic
chr5:154241860(+) A-I      intronic
chr5:154245761(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CNOT8
chr5:154255685(+) A-I exon 3'UTR    19478186
chr5:154245861(+) A-I intron -    22327324
chr5:154243064(+) A-I intron -    21960545
chr5:154244359(+) A-I intron -    21960545
chr5:154245826(+) A-I intron -    21960545
chr5:154241278(+) A-G intron -    22484847
chr5:154241388(+) A-G intron -    22484847
chr5:154241443(+) A-G intron -    22484847
chr5:154241445(+) A-G intron -    22484847
chr5:154241465(+) A-G intron -    22484847
chr5:154241845(+) A-G intron -    22484847
chr5:154241860(+) A-G intron -    22484847
chr5:154241907(+) A-G intron -    22484847
chr5:154241909(+) A-G intron -    22484847
chr5:154241919(+) A-G intron -    22484847
chr5:154243064(+) A-G intron -    22484847
chr5:154243938(+) A-G intron -    22484847
chr5:154245761(+) A-G intron -    22484847
chr5:154245770(+) A-G intron -    22484847
chr5:154245786(+) A-G intron -    22484847
chr5:154245826(+) A-G intron -    22484847
chr5:154245847(+) A-G intron -    22484847
chr5:154245861(+) A-G intron -    22484847
chr5:154246209(+) A-G intron -    22484847
chr5:154246215(+) A-G intron -    22484847
chr5:154246230(+) C-T intron -    22484847
chr5:154246353(+) A-G intron -    22484847
chr5:154247621(+) C-T intron -    22484847
chr5:154247622(+) G-A intron -    22484847
chr5:154248804(+) T-C intron -    22484847
chr5:154253875(+) A-G intron -    22484847
chr5:154254015(+) A-G intron -    22484847
chr5:154254016(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CNOT8
chr5:154237997-154237998(+) m6A 5'UTR//exon//intron       -
chr5:154238149-154238150(+) m6A 5'UTR//intron       24981863
chr5:154252139-154252140(+) Am 3'UTR//CDS//exon       -
chr5:154254862-154254863(+) m6A 3'UTR//CDS       24209618
chr5:154254943-154254944(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085
chr5:154255129-154255130(+) m6A 3'UTR       24284625//24209618//24981863//22608085
chr5:154255147-154255148(+) m6A 3'UTR       24284625//24209618//24981863//22608085
chr5:154255169-154255170(+) m6A 3'UTR       24284625//24209618//24981863//22608085
chr5:154255300-154255301(+) m6A 3'UTR       24284625
chr5:154256135-154256136(+) m6A 3'UTR       27773535
chr5:154256147-154256148(+) m6A 3'UTR       26404942//27773535
chr5:154256153-154256154(+) m6A 3'UTR       26404942//27773535
chr5:154256180-154256181(+) m6A 3'UTR       26404942//27773535
chr5:154256235-154256236(+) m6A 3'UTR       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-29b-3p
Cytoplasm HeLa cells     28185889
Cytoplasm Hepatic carcinoma cells (Huh-7)     29253196
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Urine     26576778
Exosome HCC tissues     30542726
Exosome Saliva     19627513
Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Epithelial cells|Seminal fluid|Tongue tissue     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Hela cells|NIH-3T3 cells     17204650
Nucleus HeLa cells     28185889
Nucleus Hepatic carcinoma cells (Huh-7)     29253196
Nucleus HeLa cells     30006350
Nucleus Nasopharyngeal carcinoma cells     20498841
CNOT8
Cytosol K562 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleoplasm K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-29b-3p
Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug resistant
Phenyl gallate 333279 Drug resistant
N-[(4R)-4-[(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Tris(3-aminopropoxy)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentyl]octan-1-amine 24205348 Drug sensitive
8-Hydroxyquinoline 1923 Drug resistant
(R)-(2,8-Bis(trifluoromethyl)quinolin-4-yl)((S)-piperidin-2-yl)methanol hydrochloride 18660697 Drug sensitive
Acid Alizarine Red B 135565636 Drug resistant
2-Acetylimidazo[4,5-b]pyridin 4 tolyl 3 thiosemicarbazone 135440014 Drug resistant
1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug resistant
4-carbo-1-thiazolidine-3-o-gluconyl-.gamma.-lactone - Drug resistant
naphth[2,3-d]oxazol-9-one, 2-methyl-4-(phenylimino)- - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-29b-3p
Formaldehyde 712 Drug interaction    RC00001120
Oxaliplatine 6857599 Drug interaction    RC00001140
Gemcitabine 60750 Drug interaction    RC00001131
Progesterone 5994 Drug interaction    RC00001126
D-Glucose 5793 Drug interaction    RC00001125
Eloxatine 5310940 Drug interaction    RC00001139
Imatinib 5291 Drug interaction    RC00001124
Decitabine 451668 Drug interaction    RC00001137
Docosahexaenoic acid 445580 Drug interaction    RC00001136
Trichostatin A 444732 Drug interaction    RC00001135
Cyclopamine 442972 Drug interaction    RC00001134
Bortezomib 387447 Drug interaction    RC00001133
Etoposide 36462 Drug interaction    RC00001130
Paclitaxel 36314 Drug interaction    RC00001129
5-Fluorouracil 3385 Drug interaction    RC00001123
Enoxacin 3229 Drug interaction    RC00001122
Doxorubicin 31703 Drug interaction    RC00001128
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001121
Tamoxifen 2733526 Drug interaction    RC00001138
Ixazomib 25183872 Drug interaction    RC00001144
Navitoclax 24978538 Drug interaction    RC00001143
Ampligen & InterferonalphaA 16197265 Drug interaction    RC00001142
Leucovorin 135403648 Drug interaction    RC00001145
Ginsenoside Rh2 119307 Drug interaction    RC00001132
Carfilzomib 11556711 Drug interaction    RC00001141
Androstanolone 10635 Drug interaction    RC00001127
Chemotherapy - Drug interaction    RC00001146
5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00001147
Glucocorticoid - Drug interaction    RC00001148
Testosterone + 1,25-Dihydroxyvitamin D3 - Drug interaction    RC00001149
Trastuzumab - Drug interaction    RC00001150
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-29b-3p
Bortezomib 387447       30728351

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-29b-3p
Interactor2: CNOT8

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

Starting a new search, please wait ...