Basic Information:

  VIRBase ID:  

HHID00003012

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-29b-3p:  MIMAT0000100          SLC7A6:  NM_003983     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-29b-3p	SLC7A6
miRBase Accession/Entrez ID	MIMAT0000100	9057
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	LAT-2//LAT3//y+LAT-2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-29b-3p	rs868994683 chr7:130877473    G/A rs1390817128 chr1:207802451    A/G rs773555186 chr1:207802453    A/C rs773555186 chr1:207802453    A/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SLC7A6	chr16:68330078(+) A-I      intronic chr16:68299676(+) A-I      intronic chr16:68313535(+) A-I      intronic chr16:68313506(+) A-I      intronic chr16:68321164(+) A-I      intronic chr16:68321133(+) A-I      intronic chr16:68320915(+) A-I      intronic chr16:68316795(+) A-I      intronic chr16:68316782(+) A-I      intronic chr16:68316601(+) A-I      intronic chr16:68316262(+) A-I      intronic chr16:68316208(+) A-I      intronic chr16:68313608(+) A-I      intronic chr16:68313590(+) A-I      intronic chr16:68313583(+) A-I      intronic chr16:68313581(+) A-I      intronic chr16:68313571(+) A-I      intronic chr16:68313497(+) A-I      intronic chr16:68313453(+) A-I      intronic chr16:68313227(+) A-I      intronic chr16:68313194(+) A-I      intronic chr16:68313178(+) A-I      intronic chr16:68313141(+) A-I      intronic chr16:68313124(+) A-I      intronic chr16:68313019(+) A-I      intronic chr16:68311631(+) A-I      intronic chr16:68311175(+) A-I      intronic chr16:68311164(+) A-I      intronic chr16:68311091(+) A-I      intronic chr16:68311090(+) A-I      intronic chr16:68310863(+) A-I      intronic chr16:68310802(+) A-I      intronic chr16:68310651(+) A-I      intronic chr16:68309404(+) A-I      intronic chr16:68309312(+) A-I      intronic chr16:68309252(+) A-I      intronic chr16:68306121(+) A-I      intronic chr16:68306115(+) A-I      intronic chr16:68305958(+) A-I      intronic chr16:68305893(+) A-I      intronic chr16:68305846(+) A-I      intronic chr16:68305834(+) A-I      intronic chr16:68305798(+) A-I      intronic chr16:68305727(+) A-I      intronic chr16:68299935(+) A-I      intronic chr16:68318781(+) A-I      intronic chr16:68320925(+) A-I      intronic chr16:68313200(+) A-I      intronic chr16:68303536(+) A-I      intronic chr16:68305343(+) A-I      intronic chr16:68313080(+) A-I      intronic chr16:68305308(+) A-I      intronic chr16:68313653(+) A-I      intronic chr16:68310783(+) A-I      intronic chr16:68303887(+) A-I      intronic chr16:68322746(+) A-I      intronic chr16:68313170(+) A-I      intronic chr16:68309313(+) A-I      intronic chr16:68321020(+) A-I      intronic chr16:68316290(+) A-I      intronic chr16:68316225(+) A-I      intronic chr16:68319813(+) A-I      intronic chr16:68313230(+) A-I      intronic chr16:68300042(+) A-I      intronic chr16:68319766(+) A-I      intronic chr16:68303523(+) A-I      intronic chr16:68309342(+) A-I      intronic chr16:68316725(+) A-I      intronic chr16:68321155(+) A-I      intronic chr16:68313467(+) A-I      intronic chr16:68313130(+) A-I      intronic chr16:68311070(+) A-I      intronic chr16:68313614(+) A-I      intronic chr16:68305326(+) A-I      intronic chr16:68305928(+) A-I      intronic chr16:68309377(+) A-I      intronic chr16:68313465(+) A-I      intronic chr16:68305164(+) A-I      intronic chr16:68310741(+) A-I      intronic chr16:68306284(+) A-I      intronic chr16:68316239(+) A-I      intronic chr16:68309309(+) A-I      intronic chr16:68311129(+) A-I      intronic chr16:68312989(+) A-I      intronic chr16:68311587(+) A-I      intronic chr16:68311015(+) A-I      intronic chr16:68306277(+) A-I      intronic chr16:68310672(+) A-I      intronic chr16:68311013(+) A-I      intronic chr16:68310645(+) A-I      intronic chr16:68314843(+) A-I      intronic chr16:68310850(+) A-I      intronic chr16:68319806(+) A-I      intronic chr16:68321157(+) A-I      intronic chr16:68310623(+) A-I      intronic chr16:68310853(+) A-I      intronic chr16:68316723(+) A-I      intronic chr16:68316540(+) A-I      intronic chr16:68316737(+) A-I      intronic chr16:68313090(+) A-I      intronic chr16:68320974(+) A-I      intronic chr16:68303582(+) A-I      intronic chr16:68316293(+) A-I      intronic chr16:68313689(+) A-I      intronic chr16:68313461(+) A-I      intronic chr16:68303895(+) A-I      intronic chr16:68316243(+) A-I      intronic chr16:68305847(+) A-I      intronic chr16:68305779(+) A-I      intronic chr16:68306343(+) A-I      intronic chr16:68310847(+) A-I      intronic chr16:68303923(+) A-I      intronic chr16:68327057(+) A-I      intronic chr16:68310717(+) A-I      intronic chr16:68312984(+) A-I      intronic chr16:68311803(+) A-I      intronic chr16:68320966(+) A-I      intronic chr16:68309244(+) A-I      intronic chr16:68319785(+) A-I      intronic chr16:68303596(+) A-I      intronic chr16:68311046(+) A-I      intronic chr16:68316238(+) A-I      intronic chr16:68310743(+) A-I      intronic chr16:68311177(+) A-I      intronic chr16:68309334(+) A-I      intronic chr16:68326448(+) A-I      intronic chr16:68312040(+) A-I      intronic chr16:68306257(+) A-I      intronic chr16:68320980(+) A-I      intronic chr16:68303607(+) A-I      intronic chr16:68305785(+) A-I      intronic chr16:68310706(+) A-I      intronic chr16:68306315(+) A-I      intronic chr16:68311069(+) A-I      intronic chr16:68319983(+) A-I      intronic chr16:68319982(+) A-I      intronic chr16:68312967(+) A-I      intronic chr16:68306218(+) A-I      intronic chr16:68313134(+) A-I      intronic chr16:68322685(+) A-I      intronic chr16:68305170(+) A-I      intronic chr16:68310740(+) A-I      intronic chr16:68319742(+) A-I      intronic chr16:68310827(+) A-I      intronic chr16:68311997(+) A-I      intronic chr16:68316682(+) A-I      intronic chr16:68306292(+) A-I      intronic chr16:68306055(+) A-I      intronic chr16:68320955(+) A-I      intronic chr16:68319720(+) A-I      intronic chr16:68313568(+) A-I      intronic chr16:68316286(+) A-I      intronic chr16:68310759(+) A-I      intronic chr16:68311896(+) A-I      intronic chr16:68311170(+) A-I      intronic chr16:68309315(+) A-I      intronic chr16:68303578(+) A-I      intronic chr16:68310791(+) A-I      intronic chr16:68319909(+) A-I      intronic chr16:68321081(+) A-I      intronic chr16:68316660(+) A-I      intronic chr16:68310646(+) A-I      intronic chr16:68319726(+) A-I      intronic chr16:68321010(+) A-I      intronic chr16:68313029(+) A-I      intronic chr16:68322614(+) A-I      intronic chr16:68305822(+) A-I      intronic chr16:68311476(+) A-I      intronic chr16:68303514(+) A-I      intronic chr16:68312983(+) A-I      intronic chr16:68309423(+) A-I      intronic chr16:68319919(+) A-I      intronic chr16:68313639(+) A-I      intronic chr16:68305784(+) A-I      intronic chr16:68323179(+) A-I      intronic chr16:68313000(+) A-I      intronic chr16:68321143(+) A-I      intronic chr16:68306062(+) A-I      intronic chr16:68306194(+) A-I      intronic chr16:68319853(+) A-I      intronic chr16:68313567(+) A-I      intronic chr16:68311488(+) A-I      intronic chr16:68309243(+) A-I      intronic chr16:68311043(+) A-I      intronic chr16:68305729(+) A-I      intronic chr16:68313644(+) A-I      intronic chr16:68319889(+) A-I      intronic chr16:68303810(+) A-I      intronic chr16:68311131(+) A-I      intronic chr16:68310742(+) A-I      intronic chr16:68312120(+) A-I      intronic chr16:68313210(+) A-I      intronic chr16:68319892(+) A-I      intronic chr16:68310736(+) A-I      intronic chr16:68311009(+) A-I      intronic chr16:68305980(+) A-I      intronic chr16:68316216(+) A-I      intronic chr16:68320998(+) A-I      intronic chr16:68321022(+) A-I      intronic chr16:68311123(+) A-I      intronic chr16:68327272(+) A-I      intronic chr16:68312132(+) A-I      intronic chr16:68313622(+) A-I      intronic chr16:68313147(+) A-I      intronic chr16:68313006(+) A-I      intronic chr16:68311107(+) A-I      intronic chr16:68327064(+) A-I      intronic chr16:68306229(+) A-I      intronic chr16:68313677(+) A-I      intronic chr16:68311579(+) A-I      intronic chr16:68306203(+) A-I      intronic chr16:68311116(+) A-I      intronic chr16:68313702(+) A-I      intronic chr16:68313125(+) A-I      intronic chr16:68309378(+) A-I      intronic chr16:68313559(+) A-I      intronic chr16:68311119(+) A-I      intronic chr16:68320913(+) A-I      intronic chr16:68303729(+) A-I      intronic chr16:68316217(+) A-I      intronic chr16:68318842(+) A-I      intronic chr16:68310751(+) A-I      intronic chr16:68311959(+) A-I      intronic chr16:68305338(+) A-I      intronic chr16:68311051(+) A-I      intronic chr16:68313542(+) A-I      intronic chr16:68311960(+) A-I      intronic chr16:68311173(+) A-I      intronic chr16:68311611(+) A-I      intronic chr16:68317949(+) A-I      intronic chr16:68316194(+) A-I      intronic chr16:68309450(+) A-I      intronic chr16:68306361(+) A-I      intronic chr16:68317978(+) A-I      intronic chr16:68313220(+) A-I      intronic chr16:68320981(+) A-I      intronic chr16:68313625(+) A-I      intronic chr16:68309241(+) A-I      intronic chr16:68318788(+) A-I      intronic chr16:68321070(+) A-I      intronic chr16:68316783(+) A-I      intronic chr16:68306179(+) A-I      intronic chr16:68311200(+) A-I      intronic chr16:68311059(+) A-I      intronic chr16:68305769(+) A-I      intronic chr16:68307804(+) A-I      5'UTR chr16:68307767(+) A-I      5'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SLC7A6	chr16:68310783(+) A-I intron -    22327324 chr16:68319853(+) A-I intron -    22327324 chr16:68317978(+) A-G intron -    22484847 chr16:68318078(+) T-C intron -    22484847 chr16:68300923(+) T-C intron -    22484847 chr16:68306203(+) A-G intron -    22484847 chr16:68306257(+) A-G intron -    22484847 chr16:68306277(+) A-G intron -    22484847 chr16:68307767(+) A-G exon 5'UTR    22484847 chr16:68309376(+) T-C intron -    22484847 chr16:68310751(+) A-G intron -    22484847 chr16:68310783(+) A-G intron -    22484847 chr16:68310850(+) A-G intron -    22484847 chr16:68311051(+) A-G intron -    22484847 chr16:68311070(+) A-G intron -    22484847 chr16:68316238(+) A-G intron -    22484847 chr16:68316243(+) A-G intron -    22484847 chr16:68318762(+) C-T intron -    22484847 chr16:68319747(+) T-C intron -    22484847 chr16:68319853(+) A-G intron -    22484847 chr16:68320925(+) A-G intron -    22484847 chr16:68320974(+) A-G intron -    22484847 chr16:68321143(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SLC7A6	chr16:68308603-68308604(+) m6A 5'UTR       24284625 chr16:68308619-68308620(+) m6A 5'UTR       24284625 chr16:68308740-68308741(+) m6A CDS       24284625 chr16:68308935-68308936(+) m6A CDS//intron       24284625//22608085 chr16:68330648-68330649(+) Y 3'UTR//CDS//exon       26075521 chr16:68331222-68331223(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22608085 chr16:68331293-68331294(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr16:68331393-68331394(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr16:68331939-68331940(+) m6A 3'UTR//intron       24981863//22608085 chr16:68332034-68332035(+) m6A 3'UTR//intron       24284625//24981863//22575960//22608085 chr16:68332042-68332043(+) m6A 3'UTR//intron       24284625//24981863//22575960//22608085 chr16:68332087-68332088(+) m6A 3'UTR//intron       24284625//24981863//27773535//22575960//22608085 chr16:68332109-68332110(+) m6A 3'UTR//intron       24284625//24981863//27773535//22575960//22608085 chr16:68332160-68332161(+) m6A 3'UTR//intron       24284625//24981863//27773535//22608085 chr16:68332177-68332178(+) m6A 3'UTR//intron       24284625//24981863//27773535//22608085 chr16:68332233-68332234(+) m6A 3'UTR//intron       24284625//22608085 chr16:68332293-68332294(+) m6A 3'UTR//intron       24284625 chr16:68332305-68332306(+) m6A 3'UTR//intron       24284625 chr16:68332352-68332353(+) m6A 3'UTR//intron       24284625//24209618 chr16:68332435-68332436(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27371828//22575960//22608085 chr16:68332517-68332518(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27371828//22575960//22608085 chr16:68332550-68332551(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr16:68332733-68332734(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085 chr16:68332758-68332759(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr16:68333344-68333345(+) m6A 3'UTR       27773535 chr16:68333795-68333796(+) m6A 3'UTR       27773535 chr16:68333844-68333845(+) m6A 3'UTR       24981863//27773535 chr16:68334362-68334363(+) m6A 3'UTR       27773535 chr16:68334448-68334449(+) m6A 3'UTR       27773535 chr16:68334545-68334546(+) m6A 3'UTR       27773535 chr16:68334912-68334913(+) m6A 3'UTR       24284625 chr16:68334946-68334947(+) m6A 3'UTR       24284625//22575960 chr16:68334999-68335000(+) m6A 3'UTR       24284625//24981863//27773535//22575960//22608085 chr16:68335090-68335091(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr16:68335125-68335126(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr16:68335154-68335155(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr16:68335163-68335164(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr16:68335173-68335174(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr16:68335215-68335216(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr16:68335647-68335648(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-29b-3p	Cytoplasm HeLa cells     28185889 Cytoplasm Hepatic carcinoma cells (Huh-7)     29253196 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Urine     26576778 Exosome HCC tissues     30542726 Exosome Saliva     19627513 Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Epithelial cells|Seminal fluid|Tongue tissue     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Hela cells|NIH-3T3 cells     17204650 Nucleus HeLa cells     28185889 Nucleus Hepatic carcinoma cells (Huh-7)     29253196 Nucleus HeLa cells     30006350 Nucleus Nasopharyngeal carcinoma cells     20498841
	SLC7A6	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-29b-3p	Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug resistant Phenyl gallate 333279 Drug resistant N-[(4R)-4-[(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Tris(3-aminopropoxy)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentyl]octan-1-amine 24205348 Drug sensitive 8-Hydroxyquinoline 1923 Drug resistant (R)-(2,8-Bis(trifluoromethyl)quinolin-4-yl)((S)-piperidin-2-yl)methanol hydrochloride 18660697 Drug sensitive Acid Alizarine Red B 135565636 Drug resistant 2-Acetylimidazo[4,5-b]pyridin 4 tolyl 3 thiosemicarbazone 135440014 Drug resistant 1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug resistant 4-carbo-1-thiazolidine-3-o-gluconyl-.gamma.-lactone - Drug resistant naphth[2,3-d]oxazol-9-one, 2-methyl-4-(phenylimino)- - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-29b-3p	Formaldehyde 712 Drug interaction    RC00001120 Oxaliplatine 6857599 Drug interaction    RC00001140 Gemcitabine 60750 Drug interaction    RC00001131 Progesterone 5994 Drug interaction    RC00001126 D-Glucose 5793 Drug interaction    RC00001125 Eloxatine 5310940 Drug interaction    RC00001139 Imatinib 5291 Drug interaction    RC00001124 Decitabine 451668 Drug interaction    RC00001137 Docosahexaenoic acid 445580 Drug interaction    RC00001136 Trichostatin A 444732 Drug interaction    RC00001135 Cyclopamine 442972 Drug interaction    RC00001134 Bortezomib 387447 Drug interaction    RC00001133 Etoposide 36462 Drug interaction    RC00001130 Paclitaxel 36314 Drug interaction    RC00001129 5-Fluorouracil 3385 Drug interaction    RC00001123 Enoxacin 3229 Drug interaction    RC00001122 Doxorubicin 31703 Drug interaction    RC00001128 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001121 Tamoxifen 2733526 Drug interaction    RC00001138 Ixazomib 25183872 Drug interaction    RC00001144 Navitoclax 24978538 Drug interaction    RC00001143 Ampligen & InterferonalphaA 16197265 Drug interaction    RC00001142 Leucovorin 135403648 Drug interaction    RC00001145 Ginsenoside Rh2 119307 Drug interaction    RC00001132 Carfilzomib 11556711 Drug interaction    RC00001141 Androstanolone 10635 Drug interaction    RC00001127 Chemotherapy - Drug interaction    RC00001146 5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00001147 Glucocorticoid - Drug interaction    RC00001148 Testosterone + 1,25-Dihydroxyvitamin D3 - Drug interaction    RC00001149 Trastuzumab - Drug interaction    RC00001150

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-29b-3p	Bortezomib 387447       30728351

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-29b-3p
Interactor2: SLC7A6

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).