Basic Information:

  VIRBase ID:  

HHID00002951

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-29b-3p:  MIMAT0000100          RAP1GDS1:  NM_001100426     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-29b-3p	RAP1GDS1
miRBase Accession/Entrez ID	MIMAT0000100	5910
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	GDS1//SmgGDS

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-29b-3p	rs868994683 chr7:130877473    G/A rs1390817128 chr1:207802451    A/G rs773555186 chr1:207802453    A/C rs773555186 chr1:207802453    A/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RAP1GDS1	chr4:99355876(+) A-I      intronic chr4:99289224(+) A-I      intronic chr4:99289431(+) A-I      intronic chr4:99290271(+) A-I      intronic chr4:99290300(+) A-I      intronic chr4:99289216(+) A-I      intronic chr4:99289242(+) A-I      intronic chr4:99289243(+) A-I      intronic chr4:99289251(+) A-I      intronic chr4:99290250(+) A-I      intronic chr4:99290253(+) A-I      intronic chr4:99290254(+) A-I      intronic chr4:99290268(+) A-I      intronic chr4:99290305(+) A-I      intronic chr4:99290306(+) A-I      intronic chr4:99290320(+) A-I      intronic chr4:99290328(+) A-I      intronic chr4:99290335(+) A-I      intronic chr4:99290258(+) A-I      intronic chr4:99221625(+) A-I      intronic chr4:99221651(+) A-I      intronic chr4:99221652(+) A-I      intronic chr4:99221668(+) A-I      intronic chr4:99232905(+) A-I      intronic chr4:99234018(+) A-I      intronic chr4:99240756(+) A-I      intronic chr4:99240772(+) A-I      intronic chr4:99240773(+) A-I      intronic chr4:99267776(+) A-I      intronic chr4:99267871(+) A-I      intronic chr4:99267897(+) A-I      intronic chr4:99267902(+) A-I      intronic chr4:99271874(+) A-I      intronic chr4:99309853(+) A-I      intronic chr4:99320654(+) A-I      intronic chr4:99320680(+) A-I      intronic chr4:99320683(+) A-I      intronic chr4:99320707(+) A-I      intronic chr4:99321074(+) A-I      intronic chr4:99321183(+) A-I      intronic chr4:99321273(+) A-I      intronic chr4:99337085(+) A-I      intronic chr4:99337087(+) A-I      intronic chr4:99337111(+) A-I      intronic chr4:99343145(+) A-I      intronic chr4:99343170(+) A-I      intronic chr4:99343230(+) A-I      intronic chr4:99343257(+) A-I      intronic chr4:99343469(+) A-I      intronic chr4:99343498(+) A-I      intronic chr4:99343569(+) A-I      intronic chr4:99343589(+) A-I      intronic chr4:99343614(+) A-I      intronic chr4:99344795(+) A-I      intronic chr4:99357039(+) A-I      intronic chr4:99357043(+) A-I      intronic chr4:99357065(+) A-I      intronic chr4:99357101(+) A-I      intronic chr4:99357111(+) A-I      intronic chr4:99357128(+) A-I      intronic chr4:99357134(+) A-I      intronic chr4:99357143(+) A-I      intronic chr4:99358813(+) A-I      intronic chr4:99358923(+) A-I      intronic chr4:99361955(+) A-I      intronic chr4:99362078(+) A-I      intronic chr4:99362830(+) A-I      intronic chr4:99362859(+) A-I      intronic chr4:99362863(+) A-I      intronic chr4:99234033(+) A-I      intronic chr4:99234042(+) A-I      intronic chr4:99234073(+) A-I      intronic chr4:99240785(+) A-I      intronic chr4:99240790(+) A-I      intronic chr4:99240791(+) A-I      intronic chr4:99355846(+) A-I      intronic chr4:99267825(+) A-I      intronic chr4:99355835(+) A-I      intronic chr4:99355836(+) A-I      intronic chr4:99343161(+) A-I      intronic chr4:99362064(+) A-I      intronic chr4:99358745(+) A-I      intronic chr4:99361995(+) A-I      intronic chr4:99358782(+) A-I      intronic chr4:99362065(+) A-I      intronic chr4:99356035(+) A-I      intronic chr4:99359873(+) A-I      intronic chr4:99232921(+) A-I      intronic chr4:99320526(+) A-I      intronic chr4:99239036(+) A-I      intronic chr4:99355946(+) A-I      intronic chr4:99358706(+) A-I      intronic chr4:99362018(+) A-I      intronic chr4:99355972(+) A-I      intronic chr4:99343549(+) A-I      intronic chr4:99355937(+) A-I      intronic chr4:99224117(+) A-I      intronic chr4:99292811(+) A-I      intronic chr4:99361969(+) A-I      intronic chr4:99321295(+) A-I      intronic chr4:99358918(+) A-I      intronic chr4:99283587(+) A-I      intronic chr4:99234180(+) A-I      intronic chr4:99359844(+) A-I      intronic chr4:99350288(+) A-I      intronic chr4:99343165(+) A-I      intronic chr4:99361925(+) A-I      intronic chr4:99292322(+) A-I      intronic chr4:99232846(+) A-I      intronic chr4:99321057(+) A-I      intronic chr4:99320518(+) A-I      intronic chr4:99356968(+) A-I      intronic chr4:99361949(+) A-I      intronic chr4:99234060(+) A-I      intronic chr4:99362820(+) A-I      intronic chr4:99360014(+) A-I      intronic chr4:99362862(+) A-I      intronic chr4:99358851(+) A-I      intronic chr4:99343473(+) A-I      intronic chr4:99266076(+) A-I      intronic chr4:99329279(+) A-I      intronic chr4:99293978(+) A-I      intronic chr4:99362823(+) A-I      intronic chr4:99358846(+) A-I      intronic chr4:99320708(+) A-I      intronic chr4:99220860(+) A-I      intronic chr4:99343204(+) A-I      intronic chr4:99213513(+) A-I      intronic chr4:99293969(+) A-I      intronic chr4:99292639(+) A-I      intronic chr4:99355961(+) A-I      intronic chr4:99343430(+) A-I      intronic chr4:99293929(+) A-I      intronic chr4:99359920(+) A-I      intronic chr4:99359946(+) A-I      intronic chr4:99320571(+) A-I      intronic chr4:99234200(+) A-I      intronic chr4:99361998(+) A-I      intronic chr4:99234099(+) A-I      intronic chr4:99286504(+) A-I      intronic chr4:99232949(+) A-I      intronic chr4:99271868(+) A-I      intronic chr4:99341650(+) A-I      intronic chr4:99323340(+) A-I      intronic chr4:99332512(+) A-I      intronic chr4:99355913(+) A-I      intronic chr4:99361986(+) A-I      intronic chr4:99356976(+) A-I      intronic chr4:99362106(+) A-I      intronic chr4:99321181(+) A-I      intronic chr4:99343110(+) A-I      intronic chr4:99343422(+) A-I      intronic chr4:99286653(+) A-I      intronic chr4:99355919(+) A-I      intronic chr4:99233010(+) A-I      intronic chr4:99355901(+) A-I      intronic chr4:99358872(+) A-I      intronic chr4:99321130(+) A-I      intronic chr4:99361912(+) A-I      intronic chr4:99358833(+) A-I      intronic chr4:99232900(+) A-I      intronic chr4:99356967(+) A-I      intronic chr4:99234887(+) A-I      intronic chr4:99321044(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	RAP1GDS1	chr4:99308657(+) A-I intron -    21960545 chr4:99321124(+) A-I intron -    21960545 chr4:99290068(+) A-G intron -    22484847 chr4:99290085(+) A-G intron -    22484847 chr4:99290221(+) A-G intron -    22484847 chr4:99290289(+) A-G intron -    22484847 chr4:99290290(+) A-G intron -    22484847 chr4:99290324(+) A-G intron -    22484847 chr4:99290339(+) A-G intron -    22484847 chr4:99220809(+) A-G intron -    22484847 chr4:99220860(+) A-G intron -    22484847 chr4:99232846(+) A-G intron -    22484847 chr4:99232921(+) A-G intron -    22484847 chr4:99239064(+) C-T intron -    22484847 chr4:99239253(+) T-C intron -    22484847 chr4:99267765(+) A-G intron -    22484847 chr4:99267796(+) A-G intron -    22484847 chr4:99271868(+) A-G intron -    22484847 chr4:99281987(+) G-C intron -    22484847 chr4:99321057(+) A-G intron -    22484847 chr4:99321181(+) A-G intron -    22484847 chr4:99323236(+) C-T intron -    22484847 chr4:99323237(+) T-C intron -    22484847 chr4:99343165(+) A-G intron -    22484847 chr4:99343422(+) A-G intron -    22484847 chr4:99343430(+) A-G intron -    22484847 chr4:99343433(+) A-G intron -    22484847 chr4:99343438(+) A-G intron -    22484847 chr4:99343473(+) A-G intron -    22484847 chr4:99343549(+) A-G intron -    22484847 chr4:99343552(+) A-G intron -    22484847 chr4:99355820(+) A-G intron -    22484847 chr4:99355841(+) A-G intron -    22484847 chr4:99355872(+) A-G intron -    22484847 chr4:99355913(+) A-G intron -    22484847 chr4:99355972(+) A-G intron -    22484847 chr4:99356034(+) A-G intron -    22484847 chr4:99356976(+) A-G intron -    22484847 chr4:99358734(+) A-G intron -    22484847 chr4:99358748(+) A-G intron -    22484847 chr4:99361912(+) A-G intron -    22484847 chr4:99361986(+) A-G intron -    22484847 chr4:99362064(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RAP1GDS1	chr4:99182645-99182646(+) m6A 5'UTR//exon       24981863 chr4:99182673-99182674(+) m6A 5'UTR//exon       24981863 chr4:99214581-99214582(+) m1A CDS//exon       26863410 chr4:99273728-99273729(+) Y 3'UTR//CDS//exon//intron       26075521 chr4:99317134-99317135(+) m6A CDS//intron       25456834 chr4:99317195-99317196(+) m6A CDS//intron       25456834 chr4:99317215-99317216(+) m6A CDS//intron       25456834 chr4:99317233-99317234(+) m6A CDS//intron       25456834 chr4:99317256-99317257(+) m6A CDS//intron       25456834 chr4:99317303-99317304(+) m6A 3'UTR//intron       25456834 chr4:99364418-99364419(+) m6A 3'UTR       24981863 chr4:99364453-99364454(+) m6A 3'UTR       24981863 chr4:99364470-99364471(+) m6A 3'UTR       24981863 chr4:99364541-99364542(+) m6A 3'UTR       24981863 chr4:99364566-99364567(+) m6A 3'UTR       24981863 chr4:99364653-99364654(+) m6A 3'UTR       25456834//24981863//22608085 chr4:99364661-99364662(+) m6A 3'UTR       25456834//24981863//22608085 chr4:99364749-99364750(+) m6A 3'UTR       24981863//22608085 chr4:99364764-99364765(+) m6A 3'UTR       24981863//22608085 chr4:99364846-99364847(+) m6A 3'UTR       24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-29b-3p	Cytoplasm HeLa cells     28185889 Cytoplasm Hepatic carcinoma cells (Huh-7)     29253196 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Urine     26576778 Exosome HCC tissues     30542726 Exosome Saliva     19627513 Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Epithelial cells|Seminal fluid|Tongue tissue     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Hela cells|NIH-3T3 cells     17204650 Nucleus HeLa cells     28185889 Nucleus Hepatic carcinoma cells (Huh-7)     29253196 Nucleus HeLa cells     30006350 Nucleus Nasopharyngeal carcinoma cells     20498841
	RAP1GDS1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-29b-3p	Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug resistant Phenyl gallate 333279 Drug resistant N-[(4R)-4-[(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Tris(3-aminopropoxy)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentyl]octan-1-amine 24205348 Drug sensitive 8-Hydroxyquinoline 1923 Drug resistant (R)-(2,8-Bis(trifluoromethyl)quinolin-4-yl)((S)-piperidin-2-yl)methanol hydrochloride 18660697 Drug sensitive Acid Alizarine Red B 135565636 Drug resistant 2-Acetylimidazo[4,5-b]pyridin 4 tolyl 3 thiosemicarbazone 135440014 Drug resistant 1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug resistant 4-carbo-1-thiazolidine-3-o-gluconyl-.gamma.-lactone - Drug resistant naphth[2,3-d]oxazol-9-one, 2-methyl-4-(phenylimino)- - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-29b-3p	Formaldehyde 712 Drug interaction    RC00001120 Oxaliplatine 6857599 Drug interaction    RC00001140 Gemcitabine 60750 Drug interaction    RC00001131 Progesterone 5994 Drug interaction    RC00001126 D-Glucose 5793 Drug interaction    RC00001125 Eloxatine 5310940 Drug interaction    RC00001139 Imatinib 5291 Drug interaction    RC00001124 Decitabine 451668 Drug interaction    RC00001137 Docosahexaenoic acid 445580 Drug interaction    RC00001136 Trichostatin A 444732 Drug interaction    RC00001135 Cyclopamine 442972 Drug interaction    RC00001134 Bortezomib 387447 Drug interaction    RC00001133 Etoposide 36462 Drug interaction    RC00001130 Paclitaxel 36314 Drug interaction    RC00001129 5-Fluorouracil 3385 Drug interaction    RC00001123 Enoxacin 3229 Drug interaction    RC00001122 Doxorubicin 31703 Drug interaction    RC00001128 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001121 Tamoxifen 2733526 Drug interaction    RC00001138 Ixazomib 25183872 Drug interaction    RC00001144 Navitoclax 24978538 Drug interaction    RC00001143 Ampligen & InterferonalphaA 16197265 Drug interaction    RC00001142 Leucovorin 135403648 Drug interaction    RC00001145 Ginsenoside Rh2 119307 Drug interaction    RC00001132 Carfilzomib 11556711 Drug interaction    RC00001141 Androstanolone 10635 Drug interaction    RC00001127 Chemotherapy - Drug interaction    RC00001146 5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00001147 Glucocorticoid - Drug interaction    RC00001148 Testosterone + 1,25-Dihydroxyvitamin D3 - Drug interaction    RC00001149 Trastuzumab - Drug interaction    RC00001150

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-29b-3p	Bortezomib 387447       30728351

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-29b-3p
Interactor2: RAP1GDS1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).