Basic Information:

  VIRBase ID:  

HHID00002940

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-29b-3p:  MIMAT0000100          PIK3R2:  NR_073517     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-29b-3p	PIK3R2
miRBase Accession/Entrez ID	MIMAT0000100	5296
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	MPPH//MPPH1//p85//p85-BETA//P85B

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-29b-3p	rs868994683 chr7:130877473    G/A rs1390817128 chr1:207802451    A/G rs773555186 chr1:207802453    A/C rs773555186 chr1:207802453    A/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PIK3R2	chr19:18269170(+) A-I      intronic chr19:18269103(+) A-I      intronic chr19:18270321(+) A-I      intronic chr19:18269098(+) A-I      intronic chr19:18269120(+) A-I      intronic chr19:18269121(+) A-I      intronic chr19:18269128(+) A-I      intronic chr19:18269145(+) A-I      intronic chr19:18274868(+) A-I      intronic chr19:18274775(+) A-I      intronic chr19:18269793(+) A-I      intronic chr19:18269202(+) A-I      intronic chr19:18274597(+) A-I      intronic chr19:18275469(+) A-I      intronic chr19:18278608(+) A-I      intronic chr19:18269178(+) A-I      intronic chr19:18276451(+) A-I      intronic chr19:18269769(+) A-I      intronic chr19:18277279(+) A-I      intronic chr19:18276360(+) A-I      intronic chr19:18276240(+) A-I      intronic chr19:18276250(+) A-I      intronic chr19:18269027(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PIK3R2	chr19:18263984-18263985(+) m6A 5'UTR       24209618 chr19:18266416-18266417(+) m6A 5'UTR       24284625//22575960 chr19:18266480-18266481(+) m6A 5'UTR       24284625//24981863//22575960//22608085 chr19:18266602-18266603(+) m6A 5'UTR       24284625//25456834//24981863//22575960//22608085 chr19:18266667-18266668(+) m6A 5'UTR       24284625//25456834//24981863//22575960//22608085 chr19:18266753-18266754(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr19:18271369-18271370(+) m6A CDS       24284625//22575960 chr19:18271734-18271735(+) m6A CDS//exon       24284625//22575960 chr19:18271893-18271894(+) m6A CDS//exon       24284625 chr19:18272829-18272830(+) m6A CDS       24209618 chr19:18274145-18274146(+) m6A CDS       24981863 chr19:18274165-18274166(+) Cm CDS       - chr19:18274189-18274190(+) m6A CDS       24981863 chr19:18277011-18277012(+) m6A 3'UTR//CDS       24981863 chr19:18277041-18277042(+) m6A 3'UTR//CDS       24284625//24981863 chr19:18277950-18277951(+) m6A 3'UTR//CDS       24284625//24981863 chr19:18278034-18278035(+) m6A 3'UTR//CDS       24284625//24981863//22575960 chr19:18278042-18278043(+) Gm 3'UTR//CDS       - chr19:18278061-18278062(+) m6A 3'UTR//CDS       24284625//24981863//22575960 chr19:18278076-18278077(+) m6A 3'UTR//CDS       24284625//24981863//22575960 chr19:18278103-18278104(+) m6A 3'UTR//CDS       24284625//24981863//22575960 chr19:18279348-18279349(+) m6A 3'UTR//CDS//exon       24284625//24981863//22575960 chr19:18280113-18280114(+) m6A 3'UTR       24209618 chr19:18280179-18280180(+) m6A 3'UTR       24284625//24209618 chr19:18280184-18280185(+) m6A 3'UTR       24284625//24209618 chr19:18280537-18280538(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr19:18280560-18280561(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr19:18280583-18280584(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr19:18280614-18280615(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr19:18280627-18280628(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr19:18280646-18280647(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr19:18280659-18280660(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr19:18280729-18280730(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085 chr19:18280842-18280843(+) m6A 3'UTR       24284625//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-29b-3p	Cytoplasm HeLa cells     28185889 Cytoplasm Hepatic carcinoma cells (Huh-7)     29253196 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Urine     26576778 Exosome HCC tissues     30542726 Exosome Saliva     19627513 Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Epithelial cells|Seminal fluid|Tongue tissue     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Hela cells|NIH-3T3 cells     17204650 Nucleus HeLa cells     28185889 Nucleus Hepatic carcinoma cells (Huh-7)     29253196 Nucleus HeLa cells     30006350 Nucleus Nasopharyngeal carcinoma cells     20498841
	PIK3R2	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus HeLa-S3 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-29b-3p	Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug resistant Phenyl gallate 333279 Drug resistant N-[(4R)-4-[(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Tris(3-aminopropoxy)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentyl]octan-1-amine 24205348 Drug sensitive 8-Hydroxyquinoline 1923 Drug resistant (R)-(2,8-Bis(trifluoromethyl)quinolin-4-yl)((S)-piperidin-2-yl)methanol hydrochloride 18660697 Drug sensitive Acid Alizarine Red B 135565636 Drug resistant 2-Acetylimidazo[4,5-b]pyridin 4 tolyl 3 thiosemicarbazone 135440014 Drug resistant 1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug resistant 4-carbo-1-thiazolidine-3-o-gluconyl-.gamma.-lactone - Drug resistant naphth[2,3-d]oxazol-9-one, 2-methyl-4-(phenylimino)- - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-29b-3p	Formaldehyde 712 Drug interaction    RC00001120 Oxaliplatine 6857599 Drug interaction    RC00001140 Gemcitabine 60750 Drug interaction    RC00001131 Progesterone 5994 Drug interaction    RC00001126 D-Glucose 5793 Drug interaction    RC00001125 Eloxatine 5310940 Drug interaction    RC00001139 Imatinib 5291 Drug interaction    RC00001124 Decitabine 451668 Drug interaction    RC00001137 Docosahexaenoic acid 445580 Drug interaction    RC00001136 Trichostatin A 444732 Drug interaction    RC00001135 Cyclopamine 442972 Drug interaction    RC00001134 Bortezomib 387447 Drug interaction    RC00001133 Etoposide 36462 Drug interaction    RC00001130 Paclitaxel 36314 Drug interaction    RC00001129 5-Fluorouracil 3385 Drug interaction    RC00001123 Enoxacin 3229 Drug interaction    RC00001122 Doxorubicin 31703 Drug interaction    RC00001128 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001121 Tamoxifen 2733526 Drug interaction    RC00001138 Ixazomib 25183872 Drug interaction    RC00001144 Navitoclax 24978538 Drug interaction    RC00001143 Ampligen & InterferonalphaA 16197265 Drug interaction    RC00001142 Leucovorin 135403648 Drug interaction    RC00001145 Ginsenoside Rh2 119307 Drug interaction    RC00001132 Carfilzomib 11556711 Drug interaction    RC00001141 Androstanolone 10635 Drug interaction    RC00001127 Chemotherapy - Drug interaction    RC00001146 5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00001147 Glucocorticoid - Drug interaction    RC00001148 Testosterone + 1,25-Dihydroxyvitamin D3 - Drug interaction    RC00001149 Trastuzumab - Drug interaction    RC00001150

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-29b-3p	Bortezomib 387447       30728351

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-29b-3p
Interactor2: PIK3R2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).