Detail Information

Basic Information:


  VIRBase ID:  

HHID00002919

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-29b-3p:           MCL1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-29b-3p MCL1
miRBase
Accession/Entrez ID		 MIMAT0000100 4170
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - bcl2-L-3//BCL2L3//EAT//Mcl-1//MCL1-ES//mcl1/EAT//MCL1L//MCL1S//TM

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-29b-3p
rs868994683 chr7:130877473    G/A
rs1390817128 chr1:207802451    A/G
rs773555186 chr1:207802453    A/C
rs773555186 chr1:207802453    A/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MCL1
chr1:150547166-150547167(-) Y 3'UTR       25219674
chr1:150547424-150547425(-) m6A 3'UTR       24981863//26404942
chr1:150547472-150547473(-) m6A 3'UTR       26404942
chr1:150547590-150547591(-) Y 3'UTR       25219674
chr1:150547632-150547633(-) m6A 3'UTR       26404942
chr1:150547747-150547748(-) m6A 3'UTR       26404942
chr1:150547800-150547801(-) m6A 3'UTR       26404942
chr1:150547820-150547821(-) m6A 3'UTR       26404942
chr1:150547851-150547852(-) m6A 3'UTR       26404942
chr1:150547875-150547876(-) m6A 3'UTR       26404942
chr1:150547902-150547903(-) m6A 3'UTR       26404942
chr1:150547985-150547986(-) m6A 3'UTR       26404942
chr1:150548068-150548069(-) m6A 3'UTR       26404942
chr1:150548154-150548155(-) m6A 3'UTR       26404942
chr1:150548172-150548173(-) m6A 3'UTR       26404942
chr1:150548209-150548210(-) m6A 3'UTR       26404942
chr1:150548222-150548223(-) m6A 3'UTR       26404942
chr1:150548589-150548590(-) m6A 3'UTR       24981863//26404942
chr1:150548638-150548639(-) m6A 3'UTR       26404942
chr1:150549312-150549313(-) m6A 3'UTR       26404942
chr1:150549407-150549408(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr1:150549533-150549534(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:150549538-150549539(-) Y 3'UTR//exon       25219674
chr1:150549553-150549554(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:150549588-150549589(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:150549619-150549620(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:150549692-150549693(-) Tm 3'UTR//exon       -
chr1:150549779-150549780(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:150549797-150549798(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:150549935-150549936(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550731-150550732(-) m6A CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550744-150550745(-) m6A CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550754-150550755(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550791-150550792(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550810-150550811(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550817-150550818(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550827-150550828(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550876-150550877(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550948-150550949(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550953-150550954(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550989-150550990(-) m6A exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150551007-150551008(-) m6A exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150551235-150551236(-) m6A exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150551372-150551373(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150551422-150551423(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150551449-150551450(-) Y CDS       26075521
chr1:150551791-150551792(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27371828//27773536//22575960
chr1:150551973-150551974(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150552109-150552110(-) m6A 5'UTR       -
chr1:150552124-150552125(-) m6A 5'UTR       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-29b-3p
Cytoplasm HeLa cells     28185889
Cytoplasm Hepatic carcinoma cells (Huh-7)     29253196
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Urine     26576778
Exosome HCC tissues     30542726
Exosome Saliva     19627513
Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Epithelial cells|Seminal fluid|Tongue tissue     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Hela cells|NIH-3T3 cells     17204650
Nucleus HeLa cells     28185889
Nucleus Hepatic carcinoma cells (Huh-7)     29253196
Nucleus HeLa cells     30006350
Nucleus Nasopharyngeal carcinoma cells     20498841
MCL1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HeLa-S3 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-29b-3p
Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug resistant
Phenyl gallate 333279 Drug resistant
N-[(4R)-4-[(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Tris(3-aminopropoxy)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentyl]octan-1-amine 24205348 Drug sensitive
8-Hydroxyquinoline 1923 Drug resistant
(R)-(2,8-Bis(trifluoromethyl)quinolin-4-yl)((S)-piperidin-2-yl)methanol hydrochloride 18660697 Drug sensitive
Acid Alizarine Red B 135565636 Drug resistant
2-Acetylimidazo[4,5-b]pyridin 4 tolyl 3 thiosemicarbazone 135440014 Drug resistant
1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug resistant
4-carbo-1-thiazolidine-3-o-gluconyl-.gamma.-lactone - Drug resistant
naphth[2,3-d]oxazol-9-one, 2-methyl-4-(phenylimino)- - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-29b-3p
Formaldehyde 712 Drug interaction    RC00001120
Oxaliplatine 6857599 Drug interaction    RC00001140
Gemcitabine 60750 Drug interaction    RC00001131
Progesterone 5994 Drug interaction    RC00001126
D-Glucose 5793 Drug interaction    RC00001125
Eloxatine 5310940 Drug interaction    RC00001139
Imatinib 5291 Drug interaction    RC00001124
Decitabine 451668 Drug interaction    RC00001137
Docosahexaenoic acid 445580 Drug interaction    RC00001136
Trichostatin A 444732 Drug interaction    RC00001135
Cyclopamine 442972 Drug interaction    RC00001134
Bortezomib 387447 Drug interaction    RC00001133
Etoposide 36462 Drug interaction    RC00001130
Paclitaxel 36314 Drug interaction    RC00001129
5-Fluorouracil 3385 Drug interaction    RC00001123
Enoxacin 3229 Drug interaction    RC00001122
Doxorubicin 31703 Drug interaction    RC00001128
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001121
Tamoxifen 2733526 Drug interaction    RC00001138
Ixazomib 25183872 Drug interaction    RC00001144
Navitoclax 24978538 Drug interaction    RC00001143
Ampligen & InterferonalphaA 16197265 Drug interaction    RC00001142
Leucovorin 135403648 Drug interaction    RC00001145
Ginsenoside Rh2 119307 Drug interaction    RC00001132
Carfilzomib 11556711 Drug interaction    RC00001141
Androstanolone 10635 Drug interaction    RC00001127
Chemotherapy - Drug interaction    RC00001146
5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00001147
Glucocorticoid - Drug interaction    RC00001148
Testosterone + 1,25-Dihydroxyvitamin D3 - Drug interaction    RC00001149
Trastuzumab - Drug interaction    RC00001150
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-29b-3p
Bortezomib 387447       30728351

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-29b-3p
Interactor2: MCL1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence miRecords
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Additional file 6. List of validated miRNA targets from miRecords and miRTarBase databases.

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