Detail Information

Basic Information:


  VIRBase ID:  

HHID00002871

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-29b-3p:           COL7A1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-29b-3p COL7A1
miRBase
Accession/Entrez ID		 MIMAT0000100 1294
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - EBD1//EBDCT//EBR1//NDNC8

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-29b-3p
rs868994683 chr7:130877473    G/A
rs1390817128 chr1:207802451    A/G
rs773555186 chr1:207802453    A/C
rs773555186 chr1:207802453    A/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase COL7A1
chr3:48601669-48601670(-) m6A 3'UTR//exon       24284625//24981863//22575960
chr3:48601780-48601781(-) m6A 3'UTR//exon       24284625//24981863//22575960
chr3:48601842-48601843(-) m6A CDS//exon       24284625
chr3:48602218-48602219(-) m6A CDS//exon       24284625
chr3:48602272-48602273(-) m6A CDS//exon       24284625
chr3:48602412-48602413(-) m6A CDS//exon       24284625
chr3:48602441-48602442(-) m6A exon//intron       24284625
chr3:48602567-48602568(-) m6A CDS//exon       24284625
chr3:48602904-48602905(-) m6A CDS//exon       24284625
chr3:48604304-48604305(-) m6A exon//intron       24284625
chr3:48604354-48604355(-) m6A CDS//exon       24284625
chr3:48604452-48604453(-) m6A CDS//exon       24284625
chr3:48605147-48605148(-) Gm CDS//exon       -
chr3:48605157-48605158(-) m6A CDS//exon       24284625//24981863
chr3:48605274-48605275(-) m6A CDS//exon       24284625//24981863//22575960
chr3:48605618-48605619(-) m6A exon//intron       24284625//22575960
chr3:48606222-48606223(-) m6A CDS//exon       24284625//22575960
chr3:48606231-48606232(-) m6A CDS//exon       24284625//22575960
chr3:48606240-48606241(-) m6A CDS//exon       24284625//22575960
chr3:48606820-48606821(-) m6A CDS//exon       24284625//24981863//22575960
chr3:48606829-48606830(-) m6A CDS//exon       24284625//24981863//22575960
chr3:48606840-48606841(-) m6A CDS//exon       24284625//24981863//22575960
chr3:48607028-48607029(-) m6A CDS//exon       24284625//24981863//22575960
chr3:48607076-48607077(-) m6A CDS//exon       24284625//24981863//27371828//22575960
chr3:48607172-48607173(-) m6A CDS//exon       24284625//24981863//27371828//22575960
chr3:48607572-48607573(-) m6A CDS//exon       24284625//24981863//27371828//22575960
chr3:48607581-48607582(-) m6A CDS//exon       24284625//24981863//27371828//22575960
chr3:48607629-48607630(-) m6A exon//intron       24284625//24981863//27371828//22575960
chr3:48607680-48607681(-) m6A exon//intron       24284625//24981863//22575960
chr3:48607762-48607763(-) m6A CDS//exon       24284625//24981863
chr3:48607901-48607902(-) m6A CDS//exon       24284625
chr3:48607912-48607913(-) m6A CDS//exon       24284625
chr3:48607930-48607931(-) m6A CDS//exon       24284625
chr3:48608086-48608087(-) m6A CDS//exon       24284625//24981863
chr3:48608104-48608105(-) m6A CDS//exon       24284625//24981863
chr3:48608340-48608341(-) m6A CDS//exon       24284625
chr3:48608630-48608631(-) m6A exon//intron       24284625
chr3:48608690-48608691(-) m6A CDS//exon       24284625
chr3:48609446-48609447(-) m6A CDS//exon       24284625
chr3:48609583-48609584(-) m6A CDS//exon       24284625
chr3:48609828-48609829(-) m6A CDS//exon       24284625
chr3:48610106-48610107(-) m6A CDS//exon       24284625
chr3:48610130-48610131(-) m6A CDS//exon       24284625
chr3:48610142-48610143(-) m6A CDS//exon       24284625
chr3:48610316-48610317(-) m6A CDS//exon       24284625
chr3:48610368-48610369(-) m6A CDS//exon       24284625//22575960
chr3:48610459-48610460(-) m6A CDS//exon       24284625
chr3:48610630-48610631(-) m6A CDS//exon       24284625//27773536
chr3:48610639-48610640(-) m6A CDS//exon       24284625//27773536
chr3:48610657-48610658(-) m6A CDS//exon       24284625//27773536
chr3:48610760-48610761(-) m6A CDS//exon       24284625//27773536
chr3:48610765-48610766(-) m6A CDS//exon       24284625//27773536
chr3:48610960-48610961(-) m6A CDS//exon       24284625
chr3:48610969-48610970(-) m6A CDS//exon       24284625
chr3:48611137-48611138(-) m6A CDS//exon       24284625//27773536
chr3:48611144-48611145(-) m6A CDS//exon       24284625//27773536
chr3:48611944-48611945(-) m6A CDS//exon       24284625//24981863//27773536
chr3:48611960-48611961(-) m6A CDS//exon       24284625//24981863//27773536
chr3:48612113-48612114(-) m6A CDS//exon       24284625//24981863//27773536//22575960
chr3:48612244-48612245(-) m6A CDS//exon       24284625//27773536//22575960
chr3:48612253-48612254(-) m6A CDS//exon       24284625//22575960
chr3:48612259-48612260(-) m6A CDS//exon       24284625//22575960
chr3:48612271-48612272(-) m6A CDS//exon       24284625//22575960
chr3:48612511-48612512(-) m6A CDS//exon       24284625//22575960
chr3:48612528-48612529(-) m6A CDS//exon       24284625//22575960
chr3:48612538-48612539(-) m6A CDS//exon       24284625//22575960
chr3:48612642-48612643(-) m6A CDS//exon       24284625//25456834//24981863//27773536//22575960
chr3:48612922-48612923(-) m6A CDS//exon       24284625
chr3:48613079-48613080(-) m6A CDS//exon       24284625//22575960
chr3:48613089-48613090(-) m6A CDS//exon       24284625//22575960
chr3:48613153-48613154(-) m6A CDS//exon       24284625//22575960
chr3:48613313-48613314(-) m6A CDS//exon       24284625//22575960
chr3:48613852-48613853(-) m6A CDS//exon       24284625//27773536//22575960
chr3:48614156-48614157(-) m6A CDS//exon       24284625//27773536//22575960
chr3:48614446-48614447(-) m6A CDS//exon       24284625//27773536//22575960
chr3:48614454-48614455(-) m6A CDS//exon       24284625//27773536//22575960
chr3:48615774-48615775(-) m6A CDS//exon       24284625//27773536//22575960
chr3:48615924-48615925(-) m6A CDS//exon       24284625//27773536//22575960
chr3:48616364-48616365(-) m6A CDS//exon       24284625//27773536//22575960
chr3:48616659-48616660(-) m6A CDS//exon       24284625//27773536//22575960
chr3:48616671-48616672(-) m6A CDS//exon       24284625//27773536//22575960
chr3:48616832-48616833(-) m6A CDS//exon       24284625//24981863//27371828//27773536//22575960
chr3:48616927-48616928(-) m6A CDS//exon       24284625//24981863//27371828//27773536//22575960
chr3:48617080-48617081(-) m6A CDS//exon       24284625//24981863//27371828//27773536
chr3:48617087-48617088(-) m6A CDS//exon       24284625//24981863//27371828//27773536
chr3:48617235-48617236(-) m6A CDS//exon       24284625//24981863//27371828//27773536
chr3:48617242-48617243(-) m6A CDS//exon       24284625//24981863//27773536
chr3:48617478-48617479(-) m6A CDS//exon       24284625//24981863//27773536
chr3:48617756-48617757(-) m6A CDS//exon       24284625//24981863//27773536
chr3:48618044-48618045(-) m6A CDS//exon       24284625//24981863//27773536
chr3:48618716-48618717(-) m6A CDS//exon       24284625//27773536
chr3:48618741-48618742(-) m6A CDS//exon       24284625//27773536
chr3:48618886-48618887(-) m6A CDS//exon       24284625//27773536
chr3:48619009-48619010(-) m6A CDS//exon       24284625//27773536
chr3:48619018-48619019(-) m6A CDS//exon       24284625
chr3:48619036-48619037(-) m6A CDS//exon       24284625
chr3:48619358-48619359(-) m6A CDS//exon       24284625
chr3:48619373-48619374(-) m6A CDS//exon       24284625
chr3:48619768-48619769(-) m6A CDS//exon       24284625
chr3:48619934-48619935(-) m6A CDS//exon       24284625
chr3:48620469-48620470(-) m6A CDS//exon       24284625//27773536
chr3:48620849-48620850(-) m6A CDS//exon       24284625
chr3:48621012-48621013(-) m6A CDS//exon       24284625
chr3:48621192-48621193(-) m6A CDS//exon       24284625
chr3:48621374-48621375(-) m6A CDS//exon       -
chr3:48621741-48621742(-) m6A CDS//exon       -
chr3:48621769-48621770(-) m6A CDS//exon       -
chr3:48621776-48621777(-) m6A CDS//exon       -
chr3:48621787-48621788(-) m6A CDS//exon       -
chr3:48621796-48621797(-) m6A CDS//exon       27773536
chr3:48621923-48621924(-) m6A CDS//exon       27773536
chr3:48621930-48621931(-) m6A CDS//exon       27773536
chr3:48621956-48621957(-) m6A CDS       24284625//27773536
chr3:48621977-48621978(-) m6A CDS       24284625//27773536
chr3:48622190-48622191(-) m6A CDS       24284625//27773536
chr3:48622346-48622347(-) m6A CDS       24284625//27773536
chr3:48622491-48622492(-) m6A CDS       24284625
chr3:48623155-48623156(-) m6A CDS       24284625
chr3:48623274-48623275(-) m6A CDS       24284625
chr3:48623561-48623562(-) m6A CDS       24284625
chr3:48623595-48623596(-) m6A CDS       24284625
chr3:48623606-48623607(-) m6A CDS       24284625//22575960
chr3:48623642-48623643(-) m6A CDS       22575960
chr3:48623813-48623814(-) m6A CDS       22575960
chr3:48624947-48624948(-) m6A CDS       22575960
chr3:48624961-48624962(-) m6A CDS       22575960
chr3:48625361-48625362(-) m6A CDS       22575960
chr3:48626112-48626113(-) m6A CDS       24284625
chr3:48626173-48626174(-) Gm CDS       -
chr3:48626181-48626182(-) m6A CDS       24284625
chr3:48626187-48626188(-) m6A CDS       24284625
chr3:48626324-48626325(-) m6A CDS       24284625//22575960
chr3:48626762-48626763(-) m6A CDS       24284625
chr3:48627685-48627686(-) Cm CDS       -
chr3:48627720-48627721(-) m6A CDS       24284625
chr3:48627743-48627744(-) m6A CDS       24284625
chr3:48627758-48627759(-) m6A CDS       24284625
chr3:48627771-48627772(-) m6A CDS       24284625//22575960
chr3:48627940-48627941(-) m6A CDS       24284625//22575960
chr3:48628008-48628009(-) m6A CDS       24284625
chr3:48628994-48628995(-) m6A CDS       22575960
chr3:48629333-48629334(-) m6A CDS       24284625//22575960
chr3:48629380-48629381(-) m6A CDS       24284625//22575960
chr3:48629429-48629430(-) m6A CDS       24284625//22575960
chr3:48629605-48629606(-) m6A CDS       24284625//22575960
chr3:48629880-48629881(-) m6A CDS       24284625
chr3:48630005-48630006(-) m6A CDS       24284625
chr3:48630014-48630015(-) m6A CDS       24284625
chr3:48630110-48630111(-) m6A CDS       24284625//22575960
chr3:48630234-48630235(-) m6A CDS       24284625
chr3:48630296-48630297(-) m6A CDS       24284625
chr3:48630343-48630344(-) m6A CDS       24284625
chr3:48630600-48630601(-) m6A CDS       24284625
chr3:48632632-48632633(-) m6A 5'UTR       24284625//24981863
chr3:48632660-48632661(-) m6A 5'UTR       24284625//24981863
chr3:48632688-48632689(-) m6A 5'UTR       24284625//24981863
chr3:48632694-48632695(-) m6A 5'UTR       24284625//24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-29b-3p
Cytoplasm HeLa cells     28185889
Cytoplasm Hepatic carcinoma cells (Huh-7)     29253196
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Urine     26576778
Exosome HCC tissues     30542726
Exosome Saliva     19627513
Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Epithelial cells|Seminal fluid|Tongue tissue     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Hela cells|NIH-3T3 cells     17204650
Nucleus HeLa cells     28185889
Nucleus Hepatic carcinoma cells (Huh-7)     29253196
Nucleus HeLa cells     30006350
Nucleus Nasopharyngeal carcinoma cells     20498841
COL7A1
Chromatin K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-29b-3p
Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug resistant
Phenyl gallate 333279 Drug resistant
N-[(4R)-4-[(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Tris(3-aminopropoxy)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentyl]octan-1-amine 24205348 Drug sensitive
8-Hydroxyquinoline 1923 Drug resistant
(R)-(2,8-Bis(trifluoromethyl)quinolin-4-yl)((S)-piperidin-2-yl)methanol hydrochloride 18660697 Drug sensitive
Acid Alizarine Red B 135565636 Drug resistant
2-Acetylimidazo[4,5-b]pyridin 4 tolyl 3 thiosemicarbazone 135440014 Drug resistant
1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug resistant
4-carbo-1-thiazolidine-3-o-gluconyl-.gamma.-lactone - Drug resistant
naphth[2,3-d]oxazol-9-one, 2-methyl-4-(phenylimino)- - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-29b-3p
Formaldehyde 712 Drug interaction    RC00001120
Oxaliplatine 6857599 Drug interaction    RC00001140
Gemcitabine 60750 Drug interaction    RC00001131
Progesterone 5994 Drug interaction    RC00001126
D-Glucose 5793 Drug interaction    RC00001125
Eloxatine 5310940 Drug interaction    RC00001139
Imatinib 5291 Drug interaction    RC00001124
Decitabine 451668 Drug interaction    RC00001137
Docosahexaenoic acid 445580 Drug interaction    RC00001136
Trichostatin A 444732 Drug interaction    RC00001135
Cyclopamine 442972 Drug interaction    RC00001134
Bortezomib 387447 Drug interaction    RC00001133
Etoposide 36462 Drug interaction    RC00001130
Paclitaxel 36314 Drug interaction    RC00001129
5-Fluorouracil 3385 Drug interaction    RC00001123
Enoxacin 3229 Drug interaction    RC00001122
Doxorubicin 31703 Drug interaction    RC00001128
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001121
Tamoxifen 2733526 Drug interaction    RC00001138
Ixazomib 25183872 Drug interaction    RC00001144
Navitoclax 24978538 Drug interaction    RC00001143
Ampligen & InterferonalphaA 16197265 Drug interaction    RC00001142
Leucovorin 135403648 Drug interaction    RC00001145
Ginsenoside Rh2 119307 Drug interaction    RC00001132
Carfilzomib 11556711 Drug interaction    RC00001141
Androstanolone 10635 Drug interaction    RC00001127
Chemotherapy - Drug interaction    RC00001146
5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00001147
Glucocorticoid - Drug interaction    RC00001148
Testosterone + 1,25-Dihydroxyvitamin D3 - Drug interaction    RC00001149
Trastuzumab - Drug interaction    RC00001150
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-29b-3p
Bortezomib 387447       30728351

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-29b-3p
Interactor2: COL7A1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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