Detail Information

Basic Information:


  VIRBase ID:  

HHID00001240

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-23a-3p:           ZNF286B:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-23a-3p ZNF286B
miRBase
Accession/Entrez ID		 MIMAT0000078 729288
Organism Homo sapiens Homo sapiens
Category miRNA pseudo
Alias - FOXO3B//ZNF286C//ZNF286L//ZNF590

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-23a-3p
rs755278286 chr19:13836597    A/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ZNF286B
chr17:18582899(-) A-I      intronic
chr17:18583226(-) A-I      intronic
chr17:18582866(-) A-I      intronic
chr17:18583161(-) A-I      intronic
chr17:18577876(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZNF286B
chr17:18565282-18565283(-) m6A 3'UTR//CDS       24981863//22608085
chr17:18565339-18565340(-) m6A 3'UTR//CDS       24981863//22608085
chr17:18565356-18565357(-) m6A 3'UTR//CDS       24981863//22608085
chr17:18565423-18565424(-) m6A 3'UTR//CDS       24981863//22608085
chr17:18565450-18565451(-) m6A 3'UTR//CDS       24981863//22608085
chr17:18565479-18565480(-) m6A 3'UTR//CDS       24981863//22608085
chr17:18565507-18565508(-) m6A 3'UTR//CDS       24981863//22608085
chr17:18565563-18565564(-) m6A 3'UTR//CDS       24981863
chr17:18565941-18565942(-) m6A 3'UTR//CDS       22608085
chr17:18565951-18565952(-) m6A 3'UTR//CDS       22608085
chr17:18566008-18566009(-) m6A 3'UTR//CDS       22608085
chr17:18566065-18566066(-) m6A 3'UTR//CDS       24981863
chr17:18566092-18566093(-) m6A 3'UTR//CDS       24981863
chr17:18566109-18566110(-) m6A 3'UTR//CDS       24981863
chr17:18566129-18566130(-) m6A 3'UTR//CDS       24981863
chr17:18566140-18566141(-) m6A 3'UTR//CDS       24981863
chr17:18566256-18566257(-) m6A 3'UTR//CDS       22608085
chr17:18566302-18566303(-) m6A 3'UTR//CDS       27371828//22608085
chr17:18566396-18566397(-) m6A 3'UTR//CDS       24981863//22608085
chr17:18566467-18566468(-) m6A 3'UTR//CDS       22608085
chr17:18566472-18566473(-) m6A CDS       22608085
chr17:18566538-18566539(-) m6A CDS       22608085
chr17:18574265-18574266(-) m6A intron       24981863
chr17:18574345-18574346(-) m6A intron       24981863
chr17:18574397-18574398(-) m6A intron       24981863
chr17:18574403-18574404(-) m6A intron       24981863
chr17:18574445-18574446(-) m6A intron       24981863
chr17:18574620-18574621(-) m6A intron       27773535
chr17:18574643-18574644(-) m6A intron       27773535
chr17:18574769-18574770(-) m6A intron       24981863
chr17:18574808-18574809(-) m6A intron       24981863
chr17:18574823-18574824(-) m6A intron       24284625//24981863
chr17:18574833-18574834(-) m6A intron       24284625//24981863
chr17:18574877-18574878(-) m6A intron       24284625//24981863
chr17:18574890-18574891(-) m6A intron       24284625//24981863
chr17:18574916-18574917(-) m6A intron       24284625//24981863//22608085
chr17:18574930-18574931(-) m6A intron       24284625//24981863//22608085
chr17:18575020-18575021(-) m6A intron       24284625//24981863//22608085
chr17:18575084-18575085(-) m6A intron       24284625//24209618//25456834//24981863//27371828//27773536//22608085
chr17:18575144-18575145(-) m6A intron       24284625//24209618//25456834//24981863//27371828//27773536//22608085
chr17:18575316-18575317(-) m6A intron       24284625//27773536//22608085
chr17:18575413-18575414(-) m6A intron       24284625//24981863//27371828//22608085
chr17:18575475-18575476(-) m6A intron       24284625//24981863//22608085
chr17:18575557-18575558(-) m6A intron       24284625//24981863//22608085
chr17:18575616-18575617(-) m6A intron       24284625//24981863//22608085
chr17:18575715-18575716(-) m6A intron       24284625//24209618//24981863//22608085
chr17:18575748-18575749(-) m6A intron       24284625//24209618//24981863
chr17:18575763-18575764(-) m6A intron       24284625//24209618//24981863
chr17:18575919-18575920(-) m6A intron       24981863//27773536//22608085
chr17:18575952-18575953(-) m6A intron       25456834//24981863//27371828//27773536//22608085
chr17:18576183-18576184(-) m6A CDS//intron       27773536
chr17:18576268-18576269(-) m6A CDS//intron       27773536
chr17:18585193-18585194(-) m6A exon//intron       24981863
chr17:18585207-18585208(-) m6A exon//intron       24981863
chr17:18585226-18585227(-) m6A exon//intron       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-23a-3p
Apoptotic body Human umbilical vein endothelial cells     19996457
Cytoplasm Cell line (HeLa)     21695135
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Pooled sera     27278097
Exosome LAC cell line (A549)     27492069
Exosome Saliva     19627513
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438
Exosome Renal cancer cells     21670082
Exosome Ovarian follicular fluid     22116803
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Colon cancer cell line (LIM1863)     25330373
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Mast cells|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Myotube     27396686
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Colon adenocarcinoma cells     20864815
ZNF286B
Chromatin K562 cells     -
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-23a-3p
Ternatin 5459184 Drug sensitive
9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 5-methoxy- - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-23a-3p
Curcumin 969516 Drug interaction    RC00000694
Formaldehyde 712 Drug interaction    RC00000675
AICA ribonucleotide 65110 Drug interaction    RC00000690
Medroxyprogesterone acetate 6279 Drug interaction    RC00000685
Irinotecan 60838 Drug interaction    RC00000689
Phenylephrine 6041 Drug interaction    RC00000684
Vincristine 5978 Drug interaction    RC00000683
Estradiol 5757 Drug interaction    RC00000682
Mitomycin 5746 Drug interaction    RC00000681
Dexamethasone 5743 Drug interaction    RC00000680
Eloxatine 5310940 Drug interaction    RC00000697
Morphine 5288826 Drug interaction    RC00000696
Diethylstilbestrol 448537 Drug interaction    RC00000693
Metformin 4091 Drug interaction    RC00000679
Carboplatinum 38904 Drug interaction    RC00000688
Etoposide 36462 Drug interaction    RC00000687
5-Fluorouracil 3385 Drug interaction    RC00000678
Enoxacin 3229 Drug interaction    RC00000677
Doxorubicin 31703 Drug interaction    RC00000686
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00000676
Tamoxifen 2733526 Drug interaction    RC00000695
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00000698
Gefitinib 123631 Drug interaction    RC00000692
1'-Acetoxychavicol acetate 119104 Drug interaction    RC00000691
modified ALLIC BFM 2002 protocol - Drug interaction    RC00000699
Bio-Oss - Drug interaction    RC00000700
Essential amino acids (EAA) - Drug interaction    RC00000701
Trastuzumab - Drug interaction    RC00000702
Chemotherapy - Drug interaction    RC00008820
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-23a-3p
Cisplatin 5702198       25356050
Cisplatin 5702198       26676926
Sirolimus 5284616       31063487
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124
Resource Symbol Drug Name PubChem ID
RNAactDrug ZNF286B
6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide       9956222
Benzamide, N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]-       9952773
1,2-Ethanediamine, N-(1,8-dimethylimidazo(1,2-a)quinoxalin-4-yl)-, monohydrochloride       9926054
Tivozanib       9911830
5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide       9903786
PI-103       9884685
Osi-930       9868037
N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide       9826528
9H-Purine, 6-(ethylthio)-9-beta-D-ribofuranosyl-(8CI)(9CI)       95846
6-Benzylthioinosine       95263
(3Ar,4R,6E,10E,11aR)-6-methyl-3-methylidene-4-[(E)-3-methylpent-2-enoyl]oxy-2-oxo-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-10-carboxylic acid       92276668
Benzethonium chloride       8478
3-Amino-7-(dimethylamino)-5-phenylphenazinium chloride       75442
Cyclopentenyl cytosine       72828
5-Methyl-1,10-phenanthroline       72791
Nonactin       72519
N-(3-Methylphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine       704473
(S)-N-Hydroxy-4-(3-methyl-2-phenylbutanamido)benzamide       6918848
Belinostat       6918638
Temsirolimus       6918289
N-(5-(4-Chloro-3-(N-(2-hydroxyethyl)sulfamoyl)phenyl)-4-methylthiazol-2-yl)acetamide       6852167
3-Hydroxy-3'-nitro-2-naphthanilide       67277
Antineoplastic-631448       6711565
AICA ribonucleotide       65110
Tanespimycin       6505803
Ispinesib mesylate       6450816
Pelitinib       6445562
4-(N-Hydroxyacetamido)stilbene       6433723
Imiquimod       57469
4-(2,4-Dinitrophenyl)sulfanyl-1-methyl-2-nitrobenzene       57359203
Phyllanthastatin 1       5477587
Mito-tempol       54613387
Curromycin A.B mixture       54608021
Aspergillic acid, dehydrodeoxy-       54600217
(10R,13R,16R,19S)-16-Butan-2-yl-3-(3-chloro-2-hydroxypropyl)-10,11,14-trimethyl-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone       5459202
2-Methylolivacinium acetate       5458752
Rubremetinium chloride       5351504
N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide       53340664
Desoximetasone       5311067
Vorinostat       5311
Isotretinoin       5282379
Alsterpaullone       5005498
Tubastatin A       49850262
Alectinib       49806720
2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one       4713
2-[(4s)-6-(4-Chlorophenyl)-8-Methoxy-1-Methyl-4h-[1,2,4]triazolo[4,3-A][1,4]benzodiazepin-4-Yl]-N-Ethylacetamide       46943432
3-(4-(4-(2-(3-((Dimethylamino)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl)phenyl)-1,1-dimethylurea       46885626
N-(6,6-Dimethyl-5-(1-methylpiperidine-4-carbonyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-3-methylbutanamide       46191454
N-(2,2,2-Trifluoroethyl)-N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}benzenesulfonamide       447912
1-(6,7-Dimethoxyquinazolin-4-yl)-3-(pyridin-2-yl)-1H-1,2,4-triazol-5-amine       44551660
1-Benzyl-3-hexadecyl-2-methylimidazolium chloride       44219704
Refametinib       44182295
Foretinib       42642645
Amethopterin       4112
Janus Red B       407803
6-Methoxy-2-(4-hydroxyphenyl)benzothiazole       404997
1-(2-(Hydroxymethyl)-1,3-dioxolan-4-yl)cytosine       381525
Sporanox       3793
2-Chloro-3-(3-(N-morpholino)propylamino)-naphthazarine       379081
1,5,9,13,17-Pentathiacycloeicosane       373845
Arabinosyl cytosine palmitate       35731
Illudin M       344199
5-Fluorouracil       3385
Cetalkonium chloride       31202
AT 116, benzylamine salt       282523
[1]Benzothieno[3,2-h]isoquinoline       278923
Flavacol       278143
[5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol       25262965
2-(4-Methyl-1,4-diazepan-1-yl)-N-((5-methylpyrazin-2-yl)methyl)-5-oxo-5H-benzo[4,5]thiazolo[3,2-a][1,8]naphthyridine-6-carboxamide       25257557
Cabozantinib       25102847
Navitoclax       24978538
Tert-Butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate       24951314
Quizartinib       24889392
Ponatinib       24826799
10-(6'-Ubiquinolyl)decyltriphenylphosphonium       24783759
4-(6,6-Dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide       24772860
Arylidene-4-chloro       24202977
(2-Methoxy-9,10-dihydrophenanthren-3-yl)methyl-dimethyl-(phenylsulfanylmethyl)azanium;bromide       24200489
Arenaemycin E       24199350
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide       24180719
Tricinolone acetophenonide       235856
2,7-Naphthalenedisulfonic acid, 3-hydroxy-4-(phenylazo)-, disodium salt       22142
6-Chloro-2-methoxy-9-[(5-piperidinopentyl)amino]acridine       219600
Nutlin-3       216345
8-Amino-5-methyl-6-phenylphenanthridin-5-ium bromide       21144180
Kinetin riboside       20345
8-Chloro-cyclicamp       17856967
Enzastaurin       176167
4-Methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide       16747388
Gsk-690693       16725726
5-Chloro-2[(E)-2-(4-nitrophenyl)vinyl]-1H-benzimidazole       15373173
Docetaxel       148124
Homidium bromide       14710
Astrazon Orange R       135747272
(Z)-3-((3-((Dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide       135659062
(E)-5-(2-(4-(2-(Dimethylamino)ethoxy)phenyl)-5-(pyridin-4-yl)-1H-imidazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime       135421339
Pac-1       135421197
Osi-027       135398516
Akt inhibitor VIII       135398501
Abiraterone       132971
Methotrexate       126941
Berberine chloride       12456
Dactolisib       11977753
N-[3-[[5-Bromo-4-[[2-(1H-imidazol-5-YL)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide       11754511
Trametinib       11707110
Megestrol acetate       11683
4,4'-(6-(2-(Difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine       11647372
4-[2-(2-Chloro-4-fluoroanilino)-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide       11634725
Idelalisib       11625818
5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine       11617559
5-(2-Phenylpyrazolo[1,5-A]pyridin-3-YL)-1H-pyrazolo[3,4-C]pyridazin-3-amine       11493598
Linifanib       11485656
N-(6-Fluoro-1H-indazol-5-yl)-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-pyridine-5-carboxamide       11373846
Pararosaniline hydrochloride       11292
1-Phenyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazole       11162021
Setoglaucine       107404
[(4-Methylphenyl)methyl](triphenyl)arsanium bromide       10672721
Dequalinium chloride       10649
Podofilox       10607
VX-702       10341154
2'-Deoxy-2'-fluorocytidine       101507
Selumetinib       10127622
Masitinib       10074640
1,4-benzenediamine (9ci), n-butyl-n'-phenyl-       -
1,4-dimethoxy-7-azaisoindole[2,1-a]quinoxalin-6(5h)-one       -
(2r,5r)-2-palmitoylamido-(3e)-octadecen-1,5-diol)       -
5,6-ethylenediquino[3,2-b       -
8-aniline-3,7-dimethyl-2,6-octadiene-s-l-cysteine       -
.alpha.-sarcin       -
Aminopterin Derivative       -
Basic Fuchsin       -
benzamide, n-(2,3-dimethylphenyl)-2-hydroxy-3-nitro- (9ci)       -
Bleomycin (50 uM)       -
Denileukin Diftitox Ontak       -
;(E)-2-methyl-10-(3,4,5-trimethoxybenzylidene)-5-(3,4,5-...       -
Genentech Cpd 10       -
g-tpp       -
JW-7-24-1       -
KIN001-236       -
KIN001-244       -
KIN001-260       -
KIN001-266       -
MPS-1-IN-1       -
naphtho[2,1-b]quinolizinium, 5-chloro-7-methyl- perchlorate       -
NPK76-II-72-1       -
nsc 701656 incorporated in micelles, 0.73% (w/w) of drug.       -
pararosaniline pamoate       -
progesterone, 11.beta.,17-dihydroxy-6.alpha.-methyl-       -
propanedinitrile, [(3,5-dibromo-2-ethoxyphenyl)methylene]-       -
protein toxin c 10 - mw approx. 6700       -
QL-X-138       -
QL-XI-92       -
QL-XII-47       -
riboprine(usan)       -
SB52334       -
sphinxolide c       -
THZ-2-102-1       -
TL-1-85       -
TL-2-105       -
triacetyl 13,14,15-isocrambescidin 800 hydrochloride       -
XMD13-2       -
XMD14-99       -
;(Z)-5-Chloro-2-(1-methyl-5-nitroimidazole-2-ylmethylene...       -
;(Z)-6-Chloro-2-(1-methyl-4-nitroimidazole-5-ylmethylene...       -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-23a-3p
Interactor2: ZNF286B

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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