Detail Information

Basic Information:


  VIRBase ID:  

HHID00000897

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-23a-3p:           CSNK2A2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-23a-3p CSNK2A2
miRBase
Accession/Entrez ID		 MIMAT0000078 1459
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CK2A2//CK2alpha'//CSNK2A1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-23a-3p
rs755278286 chr19:13836597    A/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CSNK2A2
chr16:58205847(-) A-I      intronic
chr16:58205839(-) A-I      intronic
chr16:58205872(-) A-I      intronic
chr16:58203390(-) A-I      intronic
chr16:58205821(-) A-I      intronic
chr16:58203850(-) A-I      intronic
chr16:58205344(-) A-I      intronic
chr16:58205278(-) A-I      intronic
chr16:58203372(-) A-I      intronic
chr16:58203352(-) A-I      intronic
chr16:58203351(-) A-I      intronic
chr16:58203119(-) A-I      intronic
chr16:58202952(-) A-I      intronic
chr16:58202891(-) A-I      intronic
chr16:58205345(-) A-I      intronic
chr16:58203193(-) A-I      intronic
chr16:58205972(-) A-I      intronic
chr16:58203358(-) A-I      intronic
chr16:58203009(-) A-I      intronic
chr16:58203276(-) A-I      intronic
chr16:58203744(-) A-I      intronic
chr16:58205303(-) A-I      intronic
chr16:58203199(-) A-I      intronic
chr16:58203365(-) A-I      intronic
chr16:58205777(-) A-I      intronic
chr16:58213293(-) A-I      intronic
chr16:58205341(-) A-I      intronic
chr16:58206022(-) A-I      intronic
chr16:58203097(-) A-I      intronic
chr16:58203011(-) A-I      intronic
chr16:58203187(-) A-I      intronic
chr16:58206002(-) A-I      intronic
chr16:58203382(-) A-I      intronic
chr16:58205992(-) A-I      intronic
chr16:58203334(-) A-I      intronic
chr16:58216178(-) A-I      intronic
chr16:58203842(-) A-I      intronic
chr16:58203874(-) A-I      intronic
chr16:58205258(-) A-I      intronic
chr16:58203008(-) A-I      intronic
chr16:58212285(-) A-I      intronic
chr16:58205172(-) A-I      intronic
chr16:58212291(-) A-I      intronic
chr16:58203295(-) A-I      intronic
chr16:58205315(-) A-I      intronic
chr16:58205264(-) A-I      intronic
chr16:58202969(-) A-I      intronic
chr16:58202942(-) A-I      intronic
chr16:58202842(-) A-I      intronic
chr16:58205841(-) A-I      intronic
chr16:58203109(-) A-I      intronic
chr16:58213296(-) A-I      intronic
chr16:58203911(-) A-I      intronic
chr16:58213403(-) A-I      intronic
chr16:58202998(-) A-I      intronic
chr16:58202985(-) A-I      intronic
chr16:58202916(-) A-I      intronic
chr16:58203010(-) A-I      intronic
chr16:58203766(-) A-I      intronic
chr16:58212280(-) A-I      intronic
chr16:58202928(-) A-I      intronic
chr16:58205287(-) A-I      intronic
chr16:58205222(-) A-I      intronic
chr16:58203102(-) A-I      intronic
chr16:58205247(-) A-I      intronic
chr16:58203841(-) A-I      intronic
chr16:58230414(-) A-I      intronic
chr16:58203059(-) A-I      intronic
chr16:58203247(-) A-I      intronic
chr16:58203786(-) A-I      intronic
chr16:58230402(-) A-I      intronic
chr16:58205184(-) A-I      intronic
chr16:58202979(-) A-I      intronic
chr16:58203309(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CSNK2A2
chr16:58202916(-) A-I intron -    22327324
chr16:58203358(-) A-G intron -    22484847
chr16:58203365(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CSNK2A2
chr16:58191908-58191909(-) m6A 3'UTR//exon       24981863//27773535
chr16:58191932-58191933(-) m6A 3'UTR//exon       24981863//27773535
chr16:58192094-58192095(-) m6A 3'UTR//exon       24284625//24981863//27773535
chr16:58192128-58192129(-) m6A 3'UTR//exon       24284625//24981863//27773535
chr16:58192133-58192134(-) m6A 3'UTR//exon       24284625//24981863//27773535
chr16:58192165-58192166(-) m6A 3'UTR//exon       24981863//27773535
chr16:58192215-58192216(-) m6A 3'UTR//exon       27773535
chr16:58192221-58192222(-) m6A 3'UTR//exon       27773535
chr16:58193463-58193464(-) m6A 3'UTR//intron       27773535
chr16:58193606-58193607(-) m6A 3'UTR//intron       24284625//27773535//22575960//22608085
chr16:58193687-58193688(-) m6A 3'UTR//intron       24284625//25456834//24981863//27773535//27371828//22575960//22608085
chr16:58193706-58193707(-) m6A 3'UTR//intron       24284625//25456834//24981863//27773535//27371828//22575960//22608085
chr16:58193732-58193733(-) m6A 3'UTR//intron       24284625//25456834//24981863//27773535//22575960//22608085
chr16:58193808-58193809(-) m6A 3'UTR//intron       24284625//24981863//27773535//22608085
chr16:58193847-58193848(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr16:58193885-58193886(-) m6A 3'UTR//intron       27773535//22608085
chr16:58193963-58193964(-) m6A 3'UTR//intron       27773535//22608085
chr16:58194050-58194051(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr16:58194096-58194097(-) m6A 3'UTR//intron       24981863//28052920//27773535//22608085
chr16:58194149-58194150(-) m6A 3'UTR//intron       24981863//28052920//27773535//22608085
chr16:58194173-58194174(-) m6A 3'UTR//intron       24981863//28052920//27773535
chr16:58194236-58194237(-) m6A 3'UTR//intron       24981863//27773535
chr16:58194244-58194245(-) m6A 3'UTR//intron       24981863//27773535
chr16:58194274-58194275(-) m6A 3'UTR//intron       27773535
chr16:58194348-58194349(-) m6A 3'UTR//intron       27773535
chr16:58194664-58194665(-) m6A 3'UTR//intron       24981863//27773535
chr16:58194708-58194709(-) m6A 3'UTR//intron       24981863//27773535
chr16:58194725-58194726(-) m6A 3'UTR//intron       24981863//27773535
chr16:58194733-58194734(-) m6A 3'UTR//intron       24981863//27773535
chr16:58194751-58194752(-) m6A 3'UTR//intron       24981863//27773535
chr16:58194825-58194826(-) m6A 3'UTR//intron       27773535
chr16:58194856-58194857(-) m6A 3'UTR//intron       27773535
chr16:58195535-58195536(-) m6A 3'UTR//intron       27773535
chr16:58195559-58195560(-) m6A 3'UTR//intron       27773535
chr16:58195576-58195577(-) m6A 3'UTR//intron       27773535
chr16:58195601-58195602(-) m6A 3'UTR//intron       27773535
chr16:58195623-58195624(-) m6A 3'UTR//intron       24284625//27773535
chr16:58195693-58195694(-) m6A 3'UTR//intron       24284625//27773535
chr16:58195969-58195970(-) m6A 3'UTR//intron       -
chr16:58197700-58197701(-) m6A 3'UTR//intron       24981863//22608085
chr16:58197805-58197806(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr16:58197836-58197837(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//27371828//22608085
chr16:58197895-58197896(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//27371828//22608085
chr16:58197908-58197909(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085
chr16:58197914-58197915(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085
chr16:58197927-58197928(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085
chr16:58197971-58197972(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085
chr16:58198014-58198015(-) m6A CDS//exon       24284625//24981863//27773535//22575960
chr16:58199500-58199501(-) m6A CDS//exon       27773535
chr16:58199531-58199532(-) m6A CDS//exon       27773535
chr16:58199570-58199571(-) m6A CDS//exon       27773535
chr16:58199588-58199589(-) m6A CDS//exon       27773535
chr16:58200489-58200490(-) m6A CDS//exon       27773535
chr16:58200520-58200521(-) m6A CDS//exon       27773535
chr16:58200552-58200553(-) m6A CDS//exon       27773535
chr16:58220665-58220666(-) m6A CDS//exon       27773535
chr16:58220699-58220700(-) m6A CDS//exon       27773535
chr16:58220713-58220714(-) m6A CDS//exon       27773535
chr16:58230717-58230718(-) m6A CDS       24209618//27773535
chr16:58231563-58231564(-) m6A CDS       24209618//27773535
chr16:58231590-58231591(-) m6A CDS       24209618//27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-23a-3p
Apoptotic body Human umbilical vein endothelial cells     19996457
Cytoplasm Cell line (HeLa)     21695135
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Pooled sera     27278097
Exosome LAC cell line (A549)     27492069
Exosome Saliva     19627513
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438
Exosome Renal cancer cells     21670082
Exosome Ovarian follicular fluid     22116803
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Colon cancer cell line (LIM1863)     25330373
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Mast cells|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Myotube     27396686
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Colon adenocarcinoma cells     20864815
CSNK2A2
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|HeLa-S3 cells     -
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Membrane HCC cell line (HepG2)     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-23a-3p
Ternatin 5459184 Drug sensitive
9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 5-methoxy- - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-23a-3p
Curcumin 969516 Drug interaction    RC00000694
Formaldehyde 712 Drug interaction    RC00000675
AICA ribonucleotide 65110 Drug interaction    RC00000690
Medroxyprogesterone acetate 6279 Drug interaction    RC00000685
Irinotecan 60838 Drug interaction    RC00000689
Phenylephrine 6041 Drug interaction    RC00000684
Vincristine 5978 Drug interaction    RC00000683
Estradiol 5757 Drug interaction    RC00000682
Mitomycin 5746 Drug interaction    RC00000681
Dexamethasone 5743 Drug interaction    RC00000680
Eloxatine 5310940 Drug interaction    RC00000697
Morphine 5288826 Drug interaction    RC00000696
Diethylstilbestrol 448537 Drug interaction    RC00000693
Metformin 4091 Drug interaction    RC00000679
Carboplatinum 38904 Drug interaction    RC00000688
Etoposide 36462 Drug interaction    RC00000687
5-Fluorouracil 3385 Drug interaction    RC00000678
Enoxacin 3229 Drug interaction    RC00000677
Doxorubicin 31703 Drug interaction    RC00000686
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00000676
Tamoxifen 2733526 Drug interaction    RC00000695
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00000698
Gefitinib 123631 Drug interaction    RC00000692
1'-Acetoxychavicol acetate 119104 Drug interaction    RC00000691
modified ALLIC BFM 2002 protocol - Drug interaction    RC00000699
Bio-Oss - Drug interaction    RC00000700
Essential amino acids (EAA) - Drug interaction    RC00000701
Trastuzumab - Drug interaction    RC00000702
Chemotherapy - Drug interaction    RC00008820
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-23a-3p
Cisplatin 5702198       25356050
Cisplatin 5702198       26676926
Sirolimus 5284616       31063487
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-23a-3p
Interactor2: CSNK2A2

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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