Detail Information

Basic Information:


  VIRBase ID:  

HHID00000596

  Virus:  

Borna disease virus 1 (BoDV-1)

  Host:  

Homo sapiens

  Confidence Score:  

0.9630

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-146a-3p:           TRAF6:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-146a-3p TRAF6
miRBase
Accession/Entrez ID		 MIMAT0004608 7189
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - MGC:3310//RNF85

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-146a-3p
rs1323710653 chr5:160485408    C/T
rs1343966428 chr5:160485421    G/C
rs529455292 chr5:160485429    G/T
rs772931224 chr5:160485420    A/G
rs1173033188 chr5:160485411    CT/C
rs1234876154 chr5:160485413    G/GA
rs2910164 chr5:160485411    C/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TRAF6
chr11:36517280(-) A-I      intronic
chr11:36508627(-) A-I      3'UTR
chr11:36517294(-) A-I      intronic
chr11:36517293(-) A-I      intronic
chr11:36508584(-) A-I      3'UTR
chr11:36508578(-) A-I      3'UTR
chr11:36508608(-) A-I      3'UTR
chr11:36508633(-) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TRAF6
chr11:36508559(-) A-I exon 3'UTR    22327324
chr11:36507686(-) A-G exon 3'UTR    21725310   //22484847
chr11:36507861(-) A-G exon 3'UTR    21725310   //22484847
chr11:36507641(-) C-A exon 3'UTR    22484847
chr11:36507687(-) A-G exon 3'UTR    22484847
chr11:36507777(-) A-G exon 3'UTR    22484847
chr11:36507807(-) A-G exon 3'UTR    22484847
chr11:36507820(-) A-G exon 3'UTR    22484847
chr11:36508454(-) A-G exon 3'UTR    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TRAF6
chr11:36511310-36511311(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr11:36511348-36511349(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr11:36511365-36511366(-) m6A 3'UTR       24284625//24209618//24981863//27773535//27371828//22608085
chr11:36511500-36511501(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr11:36511507-36511508(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr11:36511556-36511557(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085
chr11:36511597-36511598(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr11:36511622-36511623(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr11:36511742-36511743(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr11:36511792-36511793(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr11:36511804-36511805(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr11:36511843-36511844(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr11:36511940-36511941(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr11:36511950-36511951(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr11:36511959-36511960(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr11:36511992-36511993(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr11:36512027-36512028(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr11:36512032-36512033(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr11:36512064-36512065(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085
chr11:36512162-36512163(-) m6A CDS//exon       24209618//27773535
chr11:36514155-36514156(-) m6A CDS//exon       27773535
chr11:36516528-36516529(-) m6A CDS//exon       27773535
chr11:36516583-36516584(-) m6A CDS//exon       27773535
chr11:36517922-36517923(-) m6A exon//intron       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-146a-3p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Mesenchymal stem cells     -
TRAF6
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Membrane K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-146a-3p
Interactor2: TRAF6

Evidence Support:


Strong-Evidence Luciferase reporter assay//RT-qPCR//Western blot
Prediction-Evidence RNAHybrid//Targetscan
Support Database ViRBase

References:


PMID 31330207 Target region 3'UTR
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line HMC3 cells Interactor2 expression None
Description Subsequently, we confirmed the interaction of miR-146a with IRAK1 and TRAF6 by luciferase assay.

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