Detail Information

Basic Information:


  VIRBase ID:  

HHID00000595

  Virus:  

Borna disease virus 1 (BoDV-1)

  Host:  

Homo sapiens

  Confidence Score:  

0.9630

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-146a-3p:           IRAK1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-146a-3p IRAK1
miRBase
Accession/Entrez ID		 MIMAT0004608 3654
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - IRAK//pelle

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-146a-3p
rs1323710653 chr5:160485408    C/T
rs1343966428 chr5:160485421    G/C
rs529455292 chr5:160485429    G/T
rs772931224 chr5:160485420    A/G
rs1173033188 chr5:160485411    CT/C
rs1234876154 chr5:160485413    G/GA
rs2910164 chr5:160485411    C/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR IRAK1
chrX:153279602(-) A-I      NonSyn:His->Arg
chrX:153276588(-) A-I      3'UTR
chrX:153276744(-) A-I      3'UTR
chrX:153276791(-) A-I      3'UTR
chrX:153276814(-) A-I      3'UTR
chrX:153276750(-) A-I      3'UTR
chrX:153276813(-) A-I      3'UTR
chrX:153276668(-) A-I      3'UTR
chrX:153276687(-) A-I      3'UTR
chrX:153276787(-) A-I      3'UTR
chrX:153276634(-) A-I      3'UTR
chrX:153276650(-) A-I      3'UTR
chrX:153280137(-) A-I      intronic
chrX:153279877(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED IRAK1
chrX:153276566(-) A-G exon 3'UTR    22484847
chrX:153276668(-) A-G exon 3'UTR    22484847
chrX:153276687(-) A-G exon 3'UTR    22484847
chrX:153276787(-) A-G exon 3'UTR    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase IRAK1
chrX:153276155-153276156(-) m6A 3'UTR       22575960
chrX:153276172-153276173(-) m6A 3'UTR//exon       22575960
chrX:153276185-153276186(-) m6A 3'UTR//exon       22575960
chrX:153276230-153276231(-) m6A 3'UTR//exon       22575960
chrX:153276244-153276245(-) m6A 3'UTR//exon       22575960
chrX:153276407-153276408(-) m6A 3'UTR//CDS//intron       -
chrX:153276542-153276543(-) m6A 3'UTR//CDS//intron       27773535
chrX:153276562-153276563(-) m6A 3'UTR//CDS//intron       27773535
chrX:153276705-153276706(-) m6A 3'UTR//intron       24209618//22575960
chrX:153276733-153276734(-) m6A 3'UTR//intron       24284625//24209618//22575960
chrX:153276756-153276757(-) m6A 3'UTR//intron       24284625//24209618//22575960
chrX:153276912-153276913(-) m6A 3'UTR//intron       24284625//24209618//25456834//27371828//27773536//22608085
chrX:153277036-153277037(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960
chrX:153277128-153277129(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//27371828//27773536//22575960
chrX:153277349-153277350(-) m6A 3'UTR//CDS//intron       24284625//24209618//27773536//22575960
chrX:153277354-153277355(-) m6A 3'UTR//CDS//intron       24284625//24209618//27773536//22575960
chrX:153278014-153278015(-) m6A 3'UTR//CDS//intron       24284625//24209618//26404942//27773536//22575960
chrX:153278552-153278553(-) m6A 3'UTR//CDS//intron       24284625//27371828//27773536//22575960
chrX:153278591-153278592(-) m6A 3'UTR//CDS//intron       24284625//27371828//27773536//22575960
chrX:153278789-153278790(-) m6A 3'UTR//CDS//exon//intron       24284625//27371828//27773536
chrX:153279595-153279596(-) m6A 3'UTR//CDS//exon//intron       24284625//27371828//27773536
chrX:153279724-153279725(-) m6A 3'UTR//CDS//exon//intron       24284625//24981863//27371828//27773536
chrX:153279784-153279785(-) m6A exon//intron       24284625//24981863//27371828//27773536//22575960
chrX:153279792-153279793(-) m6A exon//intron       24284625//24981863//27371828//27773536//22575960
chrX:153279815-153279816(-) m6A exon//intron       24284625//24981863//27371828//27773536//22575960
chrX:153281493-153281494(-) m6A 3'UTR//CDS//exon//intron       24284625//24981863//27371828//27773536//22575960
chrX:153281535-153281536(-) m6A 3'UTR//CDS//exon//intron       24284625//27371828//27773536//22575960
chrX:153281906-153281907(-) m6A 3'UTR//CDS//exon//intron       24284625//27371828//27773536//22575960
chrX:153281912-153281913(-) m6A 3'UTR//CDS//exon//intron       24284625//27371828//27773536//22575960
chrX:153281976-153281977(-) m6A 3'UTR//CDS//exon//intron       24284625//27371828//27773536//22575960
chrX:153281982-153281983(-) m6A 3'UTR//CDS//exon//intron       24284625//27371828//27773536//22575960
chrX:153282050-153282051(-) m6A 3'UTR//CDS//exon//intron       24284625//27773536//22575960
chrX:153282408-153282409(-) m6A CDS//exon//intron       24284625//27773536//22575960
chrX:153282432-153282433(-) m6A CDS//exon//intron       24284625//27773536//22575960
chrX:153282477-153282478(-) m6A CDS//exon//intron       24284625//27773536//22575960
chrX:153283472-153283473(-) m6A CDS//exon//intron       24284625//27773536//22575960
chrX:153283547-153283548(-) m6A CDS//exon//intron       24284625//27773536//22575960
chrX:153283556-153283557(-) m6A CDS//exon//intron       24284625//27773536//22575960
chrX:153283787-153283788(-) m6A CDS//exon//intron       24284625//27773536//22575960
chrX:153284080-153284081(-) m6A CDS//exon//intron       24284625//22575960
chrX:153284129-153284130(-) Am CDS//exon//intron       -
chrX:153284268-153284269(-) m6A exon//intron       24284625
chrX:153284274-153284275(-) m6A exon//intron       24284625
chrX:153284390-153284391(-) m6A exon//intron       24284625
chrX:153284511-153284512(-) m6A CDS       24284625//27773536//22575960
chrX:153284895-153284896(-) m6A CDS       24284625//27773536//22575960
chrX:153285025-153285026(-) m6A CDS       24284625//27773536//22575960
chrX:153285336-153285337(-) m6A 5'UTR       24209618//24981863//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-146a-3p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Mesenchymal stem cells     -
IRAK1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-146a-3p
Interactor2: IRAK1

Evidence Support:


Strong-Evidence Luciferase reporter assay//RT-qPCR//Western blot
Prediction-Evidence RNAHybrid//Targetscan
Support Database ViRBase

References:


PMID 31330207 Target region 3'UTR
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line HMC3 cells Interactor2 expression None
Description Subsequently, we confirmed the interaction of miR-146a with IRAK1 and TRAF6 by luciferase assay.

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