Detail Information

Basic Information:


  VIRBase ID:  

HHID00000547

  Virus:  

Infectious bursal disease virus (IBDV)

  Host:  

Gallus gallus

  Confidence Score:  

0.8808

  Interaction Type:  

Host-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol Anti-MicHsp90a6 HSP90AA1
miRBase
Accession/Entrez ID		 Anti-MicHsp90a6 423463
Organism Gallus gallus Gallus gallus
Category miRNA mRNA
Alias - -

Interaction Network (The top 100 interactions):


Interactor1: Anti-MicHsp90a6
Interactor2: HSP90AA1

Evidence Support:


Strong-Evidence Luciferase reporter assay//RT-PCR
Support Database VIRmiRNA

References:


PMID 22238234 Target region CDS
Source VIRmiRNA Interactor1 expression None
Tissue or cell line DF-1 cells Interactor2 expression None
Description Compared with cotransfection with the control miVP2con vector, co-transfection with three out of four anti-cHsp90alpha and two out of three anti-cHsp90beta miRNA vectors resulted in a significant decrease in the number of EGFP-positive cells. According to their higher gene-silencing effects on cHsp90 transcription, two anti-cHsp90alpha miRNAs (micHsh90alpha1 and micHsh90alpha3) and one anti-cHsp90beta miRNA (micHsp90beta9) were selected for a stable transfection study.

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