Detail Information

Basic Information:


  VIRBase ID:  

HHID00000521

  Virus:  

Infectious bursal disease virus (IBDV)

  Host:  

Gallus gallus

  Confidence Score:  

0.8589

  Interaction Type:  

Host-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol LOC107051710 STAT1
miRBase
Accession/Entrez ID		 107051710 424044
Organism Gallus gallus Gallus gallus
Category lncRNA mRNA
Alias - -

Interaction Network (The top 100 interactions):


Interactor1: LOC107051710
Interactor2: STAT1

Evidence Support:


Strong-Evidence RT-qPCR
Weak-Evidence RNA-Seq
Support Database ViRBase

References:


PMID 31865850 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line DF-1 cells Interactor2 expression Downregulation
Description We confirmed the cascade relationship between loc107051710 and IRF8 and found that loc107051710 positively regulates the expression of IRF8. In addition, we found that loc107051710 acts as a positive transcriptional regulator of the antiviral-related IFN-alpha, IFN-beta, STAT1, STAT2, OAS, Mx1 and PKR.Moreover, the decrease in loc107051710 expression was accompanied by a decrease in IRF8 expression (Figure 7(b)). Surprisingly, silencing loc107051710 decreased the levels of type I IFNs, STATs, and ISGs (Figures 8 and 9).

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