Basic Information:

  VIRBase ID:  

HHID00000455

  Virus:  

Porcine reproductive and respiratory syndrome virus 2 (PRRSV-2)

  Host:  

Sus scrofa

  Confidence Score:  

0.9642

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      ssc-miR-331-3p:  MIMAT0013930          TNF:  NM_214022     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ssc-miR-331-3p	TNF
miRBase Accession/Entrez ID	MIMAT0013930	397086
Organism	Sus scrofa	Sus scrofa
Category	miRNA	mRNA
Alias	-	TNFa

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ssc-miR-331-3p	Exosome Porcine milk     24499489

Interaction Network (The top 100 interactions):

Interactor1: ssc-miR-331-3p
Interactor2: TNF

Evidence Support:

Strong-Evidence	Luciferase reporter assay//qRT-PCR//Western blot
Prediction-Evidence	miRBase//RNAHybrid//Targetscan//ViTa
Support Database	ViRBase

References:

PMID	33072088	Target region	3'UTR
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	MARC-145 cells	Interactor2 expression	None
Description	As shown in Figure 3A, mir-331-3p significantly inhibited the expression of porcine TNF-alpha (p = 0.03), TNFAIP1 (p = 0.011), SOCS1 (p = 0.019), and SCARA3 (p = 0.05) gene.