ncRNADetailInformation

Detail Information
Functional analysis

miRNA name

pre-miRNA

family

pre-miRNA Sequence

mature-miRNA

mature sequence

pre-miRNA description

miR-449a

MI0001648	MIPF0000133	CUGUGUGUGAUGAGCUGGCAGUGUAUUGUUAGCUGGUUGAAUAUGUGAAUGGCAUCGGCUAACAUGCAACUGCUGUCUUAUUGCAUAUACA	MIMAT0001541 hsa-miR-449a	UGGCAGUGUAUUGUUAGCUGGU
MI0001648	MIPF0000133	CUGUGUGUGAUGAGCUGGCAGUGUAUUGUUAGCUGGUUGAAUAUGUGAAUGGCAUCGGCUAACAUGCAACUGCUGUCUUAUUGCAUAUACA	MIMAT0001541 hsa-miR-449a	UGGCAGUGUAUUGUUAGCUGGU
MI0001648	MIPF0000133	CUGUGUGUGAUGAGCUGGCAGUGUAUUGUUAGCUGGUUGAAUAUGUGAAUGGCAUCGGCUAACAUGCAACUGCUGUCUUAUUGCAUAUACA	MIMAT0001541 hsa-miR-449a	UGGCAGUGUAUUGUUAGCUGGU
MI0001648	MIPF0000133	CUGUGUGUGAUGAGCUGGCAGUGUAUUGUUAGCUGGUUGAAUAUGUGAAUGGCAUCGGCUAACAUGCAACUGCUGUCUUAUUGCAUAUACA	MIMAT0001541 hsa-miR-449a	UGGCAGUGUAUUGUUAGCUGGU
MI0001648	MIPF0000133	CUGUGUGUGAUGAGCUGGCAGUGUAUUGUUAGCUGGUUGAAUAUGUGAAUGGCAUCGGCUAACAUGCAACUGCUGUCUUAUUGCAUAUACA	MIMAT0001541 hsa-miR-449a	UGGCAGUGUAUUGUUAGCUGGU
MI0001648	MIPF0000133	CUGUGUGUGAUGAGCUGGCAGUGUAUUGUUAGCUGGUUGAAUAUGUGAAUGGCAUCGGCUAACAUGCAACUGCUGUCUUAUUGCAUAUACA	MIMAT0001541 hsa-miR-449a	UGGCAGUGUAUUGUUAGCUGGU
MI0001648	MIPF0000133	CUGUGUGUGAUGAGCUGGCAGUGUAUUGUUAGCUGGUUGAAUAUGUGAAUGGCAUCGGCUAACAUGCAACUGCUGUCUUAUUGCAUAUACA	MIMAT0001541 hsa-miR-449a	UGGCAGUGUAUUGUUAGCUGGU
MI0001648	MIPF0000133	CUGUGUGUGAUGAGCUGGCAGUGUAUUGUUAGCUGGUUGAAUAUGUGAAUGGCAUCGGCUAACAUGCAACUGCUGUCUUAUUGCAUAUACA	MIMAT0001541 hsa-miR-449a	UGGCAGUGUAUUGUUAGCUGGU
MI0001648	MIPF0000133	CUGUGUGUGAUGAGCUGGCAGUGUAUUGUUAGCUGGUUGAAUAUGUGAAUGGCAUCGGCUAACAUGCAACUGCUGUCUUAUUGCAUAUACA	MIMAT0001541 hsa-miR-449a	UGGCAGUGUAUUGUUAGCUGGU
MI0001648	MIPF0000133	CUGUGUGUGAUGAGCUGGCAGUGUAUUGUUAGCUGGUUGAAUAUGUGAAUGGCAUCGGCUAACAUGCAACUGCUGUCUUAUUGCAUAUACA	MIMAT0001541 hsa-miR-449a	UGGCAGUGUAUUGUUAGCUGGU
MI0001648	MIPF0000133	CUGUGUGUGAUGAGCUGGCAGUGUAUUGUUAGCUGGUUGAAUAUGUGAAUGGCAUCGGCUAACAUGCAACUGCUGUCUUAUUGCAUAUACA	MIMAT0001541 hsa-miR-449a	UGGCAGUGUAUUGUUAGCUGGU
MI0001648	MIPF0000133	CUGUGUGUGAUGAGCUGGCAGUGUAUUGUUAGCUGGUUGAAUAUGUGAAUGGCAUCGGCUAACAUGCAACUGCUGUCUUAUUGCAUAUACA	MIMAT0001541 hsa-miR-449a	UGGCAGUGUAUUGUUAGCUGGU
MI0001648	MIPF0000133	CUGUGUGUGAUGAGCUGGCAGUGUAUUGUUAGCUGGUUGAAUAUGUGAAUGGCAUCGGCUAACAUGCAACUGCUGUCUUAUUGCAUAUACA	MIMAT0001541 hsa-miR-449a	UGGCAGUGUAUUGUUAGCUGGU
MI0001648	MIPF0000133	CUGUGUGUGAUGAGCUGGCAGUGUAUUGUUAGCUGGUUGAAUAUGUGAAUGGCAUCGGCUAACAUGCAACUGCUGUCUUAUUGCAUAUACA	MIMAT0001541 hsa-miR-449a	UGGCAGUGUAUUGUUAGCUGGU
MI0001648	MIPF0000133	CUGUGUGUGAUGAGCUGGCAGUGUAUUGUUAGCUGGUUGAAUAUGUGAAUGGCAUCGGCUAACAUGCAACUGCUGUCUUAUUGCAUAUACA	MIMAT0001541 hsa-miR-449a	UGGCAGUGUAUUGUUAGCUGGU
MI0001648	MIPF0000133	CUGUGUGUGAUGAGCUGGCAGUGUAUUGUUAGCUGGUUGAAUAUGUGAAUGGCAUCGGCUAACAUGCAACUGCUGUCUUAUUGCAUAUACA	MIMAT0001541 hsa-miR-449a	UGGCAGUGUAUUGUUAGCUGGU
MI0001648	MIPF0000133	CUGUGUGUGAUGAGCUGGCAGUGUAUUGUUAGCUGGUUGAAUAUGUGAAUGGCAUCGGCUAACAUGCAACUGCUGUCUUAUUGCAUAUACA	MIMAT0001541 hsa-miR-449a	UGGCAGUGUAUUGUUAGCUGGU

link to database

TargetScanS 6.2 | MicroCosm | microRNA.org | miRNAMap 2.0

Interacted genes from RAID,miRTarBase

CDK4,CCND1,GMNN,SIRT1,HDAC8,BCL2,MET,HDAC1,HNF4A,WISP2,CCNE2,CDK6,CDC25A
more » CDK4,CCND1,GMNN,SIRT1,HDAC8,BCL2,MET,HDAC1,HNF4A,WISP2,CCNE2,CDK6,CDC25A

KEGG pathways enriched for interacted genes

pathway name

pathway description

target genes enrich in pathway

p-value

hsa04110	Cell cycle	CCND1,CDK6,CCNE2,CDC25A,HDAC1,CDK4,	9.65E-7
hsa05200	Pathways in cancer	CCND1,CDK6,CCNE2,BCL2,HDAC1,CDK4,MET,	4.90E-6
hsa05222	Small cell lung cancer	CCND1,CDK6,CCNE2,BCL2,CDK4,	8.20E-6
hsa04115	p53 signaling pathway	CCND1,CDK6,CCNE2,CDK4,	1.81E-4
hsa05218	Melanoma	CCND1,CDK6,CDK4,MET,	2.06E-4

Gene ontology terms enriched for interacted genes

GO terms

GO terms description

target genes enrich in GO term

p-value

GO:0051726	regulation of cell cycle	CCND1,CDK6,CCNE2,HNF4A,BCL2,CDC25A,HDAC1,CDK4,GMNN,	1.36E-10
GO:0042127	regulation of cell proliferation	CCND1,CDK6,HNF4A,BCL2,WISP2,NOTCH1,HDAC1,CDK4,SIRT1,	1.25E-7
GO:0045786	negative regulation of cell cycle	CDK6,HNF4A,BCL2,HDAC1,GMNN,	8.18E-7
GO:0051329	interphase of mitotic cell cycle	CCND1,CDK6,BCL2,CDC25A,CDK4,	2.14E-6
GO:0051325	interphase	CCND1,CDK6,BCL2,CDC25A,CDK4,	2.41E-6

GO:0051301	cell division	CCND1,CDK6,CCNE2,CDC25A,NOTCH1,CDK4,	5.31E-6
GO:0000082	G1/S transition of mitotic cell cycle	CCND1,BCL2,CDC25A,CDK4,	1.86E-5
GO:0008284	positive regulation of cell proliferation	CCND1,CDK6,BCL2,NOTCH1,HDAC1,CDK4,	2.75E-5
GO:0045596	negative regulation of cell differentiation	CCND1,CDK6,NOTCH1,HDAC1,SIRT1,	4.03E-5
GO:0007049	cell cycle	CCND1,CDK6,CCNE2,BCL2,CDC25A,CDK4,GMNN,	4.23E-5
GO:0042325	regulation of phosphorylation	CCND1,CCNE2,HNF4A,BCL2,CDC25A,MET,	4.85E-5
GO:0051174	regulation of phosphorus metabolic process	CCND1,CCNE2,HNF4A,BCL2,CDC25A,MET,	5.88E-5
GO:0019220	regulation of phosphate metabolic process	CCND1,CCNE2,HNF4A,BCL2,CDC25A,MET,	5.88E-5
GO:0010551	regulation of specific transcription from RNA polymerase II promoter	HNF4A,NOTCH1,HDAC1,SIRT1,	8.83E-5
GO:0016575	histone deacetylation	HDAC1,SIRT1,HDAC8,	1.14E-4
GO:0006476	protein amino acid deacetylation	HDAC1,SIRT1,HDAC8,	1.94E-4
GO:0048742	regulation of skeletal muscle fiber development	BCL2,NOTCH1,HDAC1,	2.52E-4
GO:0032583	regulation of gene-specific transcription	HNF4A,NOTCH1,HDAC1,SIRT1,	2.52E-4
GO:0000278	mitotic cell cycle	CCND1,CDK6,BCL2,CDC25A,CDK4,	3.23E-4
GO:0048641	regulation of skeletal muscle tissue development	BCL2,NOTCH1,HDAC1,	3.41E-4
GO:0051153	regulation of striated muscle cell differentiation	BCL2,NOTCH1,HDAC1,	4.16E-4
GO:0022403	cell cycle phase	CCND1,CDK6,BCL2,CDC25A,CDK4,	4.96E-4
GO:0051147	regulation of muscle cell differentiation	BCL2,NOTCH1,HDAC1,	6.19E-4
GO:0010604	positive regulation of macromolecule metabolic process	CCND1,HNF4A,BCL2,NOTCH1,HDAC1,CDK4,	8.45E-4
GO:0016202	regulation of striated muscle tissue development	BCL2,NOTCH1,HDAC1,	1.01E-2
GO:0048634	regulation of muscle development	BCL2,NOTCH1,HDAC1,	1.05E-2
GO:0000079	regulation of cyclin-dependent protein kinase activity	CCND1,CCNE2,CDC25A,	1.18E-2
GO:0010552	positive regulation of specific transcription from RNA polymerase II promoter	HNF4A,NOTCH1,HDAC1,	1.32E-2
GO:0006796	phosphate metabolic process	CCND1,CDK6,BCL2,CDC25A,CDK4,MET,	1.50E-2
GO:0006793	phosphorus metabolic process	CCND1,CDK6,BCL2,CDC25A,CDK4,MET,	1.50E-2
GO:0022402	cell cycle process	CCND1,CDK6,BCL2,CDC25A,CDK4,	1.59E-2
GO:0031099	regeneration	CCND1,BCL2,NOTCH1,	1.92E-2
GO:0006468	protein amino acid phosphorylation	CCND1,CDK6,BCL2,CDK4,MET,	2.92E-2
GO:0043193	positive regulation of gene-specific transcription	HNF4A,NOTCH1,HDAC1,	3.04E-2
GO:0045859	regulation of protein kinase activity	CCND1,CCNE2,CDC25A,MET,	3.88E-2
GO:0006357	regulation of transcription from RNA polymerase II promoter	HNF4A,NOTCH1,HDAC1,SIRT1,HDAC8,	4.00E-2
GO:0010605	negative regulation of macromolecule metabolic process	HNF4A,HDAC1,GMNN,SIRT1,HDAC8,	4.14E-2
GO:0043549	regulation of kinase activity	CCND1,CCNE2,CDC25A,MET,	4.28E-2
GO:0008285	negative regulation of cell proliferation	CDK6,HNF4A,BCL2,WISP2,	4.41E-2
GO:0051338	regulation of transferase activity	CCND1,CCNE2,CDC25A,MET,	4.80E-2
GO:0008406	gonad development	CCND1,BCL2,SIRT1,	4.99E-2
GO:0016310	phosphorylation	CCND1,CDK6,BCL2,CDK4,MET,	5.64E-2
GO:0016570	histone modification	HDAC1,SIRT1,HDAC8,	5.89E-2
GO:0048608	reproductive structure development	CCND1,BCL2,SIRT1,	6.27E-2
GO:0016569	covalent chromatin modification	HDAC1,SIRT1,HDAC8,	6.27E-2
GO:0045137	development of primary sexual characteristics	CCND1,BCL2,SIRT1,	6.37E-2
GO:0048511	rhythmic process	BCL2,CDK4,SIRT1,	6.47E-2
GO:0032880	regulation of protein localization	HNF4A,BCL2,SIRT1,	7.48E-2
GO:0033158	regulation of protein import into nucleus, translocation	HNF4A,SIRT1,	8.61E-2
GO:0007548	sex differentiation	CCND1,BCL2,SIRT1,	8.90E-2
GO:0007346	regulation of mitotic cell cycle	CCND1,HNF4A,BCL2,	9.01E-2
GO:0051098	regulation of binding	HNF4A,BCL2,SIRT1,	9.13E-2
GO:0032268	regulation of cellular protein metabolic process	CCND1,HNF4A,BCL2,CDK4,	9.40E-2

KEGG pathways and Gene Ontology terms enriched for the interacted genes of ncRNA from RAID and miRTarBase.

disease name	related genes	p-value