ncRNADetailInformation

Detail Information
Functional analysis

miRNA name

pre-miRNA

family

pre-miRNA Sequence

mature-miRNA

mature sequence

pre-miRNA description

miR-424-5p

MI0001446

MIPF0000164

CGAGGGGAUACAGCAGCAAUUCAUGUUUUGAAGUGUUCUAAAUGGUUCAAAACGUGAGGCGCUGCUAUACCCCCUCGUGGGGAAGGUAGAAGGUGGGG

MIMAT0001341

hsa-miR-424-5p

CAGCAGCAAUUCAUGUUUUGAA

This hairpin precursor expresses a 5' arm product, named miR-424, in humanpromyelocytic leukemia (HL-60) cells . The level of expression ofmiR-424 was shown to be up-regulated 48 hours after TPA-induction. Thesequence is orthologous to the experimentally verified rat miR-322 locus(MIR:MI0000589), which expresses its mature product from the 3' arm of thehairpin. The human miR-424 hairpin does not appear to contain the miR-322sequence.

link to database

TargetScanS 6.2 | MicroCosm | microRNA.org | miRNAMap 2.0

Interacted genes from RAID,miRTarBase

CCNE1,WEE1,CDK6,NFIA,HIST2H2AA3,MYB,CDC25A,TMF1,GTF2A1,TRAP1,ITPR1,CCND1,SPI1,FGFR1,CCIN
more » CCNE1,WEE1,CDK6,NFIA,HIST2H2AA3,MYB,CDC25A,TMF1,GTF2A1,TRAP1,ITPR1,CCND1,SPI1,FGFR1,CCIN,PLAG1,BAZ2B,HIST1H2BK,ANLN,CHEK1,APBB2,EIF4G2,C7orf59,TBPL1,MAP2K1,YWHAQ,TTC39A,SACS,PNISR,PIAS1,CCNF,SCOC,ANKRD17,KIF23,ANKHD1,HIF1A,SMARCA5,IFIH1,MAGED1,SIAH1,SOCS6,ATF6,CCND3,RBM4B,CNIH4,IARS,SMURF1,CUL2

KEGG pathways enriched for interacted genes

pathway name

pathway description

target genes enrich in pathway

p-value

hsa04110	Cell cycle	CCND1,YWHAQ,CDK6,CDC14A,CDC25A,CHEK1,WEE1,CCNE1,CCND3,	1.14E-7
hsa04115	p53 signaling pathway	CCND1,CDK6,CHEK1,SIAH1,CCNE1,CCND3,	1.95E-5
hsa05200	Pathways in cancer	CCND1,PIAS1,CDK6,CUL2,MAP2K1,HIF1A,SPI1,CCNE1,FGFR1,	1.53E-4
hsa05218	Melanoma	CCND1,CDK6,MAP2K1,FGFR1,	5.38E-2
hsa05222	Small cell lung cancer	CCND1,PIAS1,CDK6,CCNE1,	8.59E-2

Gene ontology terms enriched for interacted genes

GO terms

GO terms description

target genes enrich in GO term

p-value

GO:0007049	cell cycle	CCND1,CDC14A,MAP2K1,CHEK1,APBB2,WEE1,ANLN,EIF4G2,CDK6,CCNF,CDC25A,CUL2,KIF23,CCNE1,SIAH1,CCND3,	1.00E-8
GO:0022402	cell cycle process	CCND1,MAP2K1,APBB2,CHEK1,WEE1,ANLN,EIF4G2,CCNF,CDK6,CDC25A,CUL2,KIF23,CCNE1,	1.55E-7
GO:0000278	mitotic cell cycle	CCND1,CDK6,CCNF,CUL2,CDC25A,KIF23,MAP2K1,CHEK1,WEE1,CCNE1,ANLN,	2.24E-7
GO:0051301	cell division	CCND1,CDK6,CCNF,CDC14A,CDC25A,KIF23,WEE1,CCNE1,ANLN,CCND3,	3.58E-7
GO:0022403	cell cycle phase	CCND1,CDK6,CCNF,CUL2,CDC25A,KIF23,MAP2K1,CHEK1,WEE1,CCNE1,ANLN,	6.31E-7

GO:0051329	interphase of mitotic cell cycle	CCND1,CDK6,CUL2,CDC25A,CHEK1,CCNE1,	1.99E-5
GO:0051325	interphase	CCND1,CDK6,CUL2,CDC25A,CHEK1,CCNE1,	2.28E-5
GO:0000279	M phase	CCNF,CDC25A,KIF23,MAP2K1,CHEK1,WEE1,ANLN,	6.40E-4
GO:0051726	regulation of cell cycle	CCND1,CDK6,CDC25A,APBB2,CHEK1,ANLN,CCND3,	6.60E-4
GO:0007067	mitosis	CCNF,CDC25A,KIF23,MAP2K1,WEE1,ANLN,	7.04E-4
GO:0000280	nuclear division	CCNF,CDC25A,KIF23,MAP2K1,WEE1,ANLN,	7.04E-4
GO:0000079	regulation of cyclin-dependent protein kinase activity	CCND1,CDC25A,CHEK1,CCND3,	7.09E-4
GO:0000087	M phase of mitotic cell cycle	CCNF,CDC25A,KIF23,MAP2K1,WEE1,ANLN,	7.63E-4
GO:0000082	G1/S transition of mitotic cell cycle	CCND1,CUL2,CDC25A,CCNE1,	7.89E-4
GO:0048285	organelle fission	CCNF,CDC25A,KIF23,MAP2K1,WEE1,ANLN,	8.43E-4
GO:0045646	regulation of erythrocyte differentiation	CDK6,HIF1A,SPI1,	1.53E-2
GO:0045449	regulation of transcription	PIAS1,YWHAQ,TMF1,MAGED1,NFIA,MAP2K1,APBB2,HIF1A,SPI1,SMARCA5,MYB,ATF6,GTF2A1,PLAG1,BAZ2B,CCNE1,TBPL1,	5.79E-2
GO:0010604	positive regulation of macromolecule metabolic process	CCND1,PIAS1,SMURF1,ATF6,MAP2K1,HIF1A,SPI1,CCNE1,CCND3,	5.80E-2
GO:0033197	response to vitamin E	CCND1,CCNE1,	6.49E-2
GO:0006355	regulation of transcription, DNA-dependent	YWHAQ,PIAS1,TMF1,MAGED1,NFIA,MAP2K1,HIF1A,SPI1,SMARCA5,MYB,ATF6,CCNE1,TBPL1,	9.23E-2

KEGG pathways and Gene Ontology terms enriched for the interacted genes of ncRNA from RAID and miRTarBase.

disease name	related genes	p-value