ncRNADetailInformation

Detail Information
Functional analysis

miRNA name

pre-miRNA

family

pre-miRNA Sequence

mature-miRNA

mature sequence

pre-miRNA description

miR-30a-5p

MI0000088

MIPF0000005

GCGACUGUAAACAUCCUCGACUGGAAGCUGUGAAGCCACAGAUGGGCUUUCAGUCGGAUGUUUGCAGCUGC

MIMAT0000087

hsa-miR-30a-5p

UGUAAACAUCCUCGACUGGAAG

The mature sequences miR-30 and miR-97 appear to originate fromthe same precursor. Subsequent data confirm that both arms of theprecursor appear to give rise to mature miRNA sequences (Pfeffer S, pers.comm.). Landgraf et al. later showed that the 5' product is thepredominant one . Related miRNAs are processed from the 5' arms ofother precursor loci (mir-30b, MIR:MI0000441; mir-30c-1, MIR:MI0000736;mir-30c-2, MIR:MI0000254; mir-30d, MIR:MI0000255; mir-30e, MI0000749).

link to database

TargetScanS 6.2 | MicroCosm | microRNA.org | miRNAMap 2.0

Interacted genes from RAID,miRTarBase

PTP4A1,CDCP1,RAB14,TMED7,WDR74,DNAJC3,KRT77,DHX8,NT5C3,NAPG,CPSF1,RAD23B,MRE11A,PIK3CD,AVEN
more » PTP4A1,CDCP1,RAB14,TMED7,WDR74,DNAJC3,KRT77,DHX8,NT5C3,NAPG,CPSF1,RAD23B,MRE11A,PIK3CD,AVEN,CDK6,IFRD2,ZNF638,MLLT11,HINT3,GABARAPL2,INTS6,WDR12,TUBA1B,POLR2C,HDAC1,ARF6,SMAD1,G3BP1,LRRFIP1,CARS,ITGA6,TRIO,PRMT1,YRDC,TMED3,GRPEL2,JUN,HIST1H1A,SLC38A5,RBM34,TNFAIP2,TNPO3,SDCBP,CPSF4,PABPC1,PPA1,GATAD2B,IFRD1,MYO10,TGFBI,FRG1,RHOB,STUB1,RBM5,KPNA1,TIMM8A,AP2A1,NDE1,CDH2,GTF2H2C,TUBB4B,EFTUD1,MGST2,LCLAT1,GLRX3,RAB21,TMED1,ATP2A2,KRT6B,ACSL4,RAB27B,CNP,RPRD1B,C1D,SMARCA1,CIRBP,DNAJA1,RPP40,MAT2A,GNG2,PES1,XPO1,RPP14,CORO1C,RBMS1,GNA13,TPI1,THUMPD1,MAN1A2,ME3,MBNL1,RRP36,CAPN2,UTP6,TMED5,PDCD10,GATC,LRRN1,PAICS,THEM4,BAX,LTN1,CLEC4D,GTF2H2,HNRNPM,PRPF40A,PDLIM7,PPP3CA,MSL2,LSM12,SNAI1,NEUROD1,NDUFAF1,OGFOD1,PICALM,SF3B3,ANXA1,GLRX,HK1,TPBG,SLC33A1,STX7,NUFIP2,SLC9A3R2,MAP2K3,PCNA,CTNNB1,DHX33,CCPG1,ITGB3,TGM2,PTPRK,RBMS3,ATOX1,GMFB,ERP44,PBRM1,STX16,IDH1,KIAA1609,LSS,P4HA2,PRKCDBP,PAFAH1B2,CTNND1,TMEM192,SARS,RUNX2,HNRNPA1L2,ITPRIP,PHB2,FNDC3B,NCKAP1,DNAJB1,GALNT1,IGF1R,GTF2H1,NT5E,SUCLA2,MAP1LC3B2,TICAM2,UTP15,SMN1,DDX10,DPY19L1,RBFOX2,REXO4,PPP2R2A,ATP6V1B2,FDX1,TIMM9,RPS17,SEC11A,GPD2,BCL6,TOM1,ZFPL1,PRPF19,SEC24A,NDEL1,CPOX,CDC20,MARCH5,VIM,DAG1,TAPBP,TIMM17A,ITGA2,UHRF2,FAHD1,AP2S1,MKI67IP,RRP15,HECTD1,EIF2C2,AP3S1,TBCB,PPP1CC,SLC7A6,SLC4A10,CPNE8,EIF1,SNX3,URM1,CD44,TUBB3,RPRD1A,ACP2,MOSPD2,DYNC1LI1,TNFRSF10B,FXR2,PPOX,DOCK7,LMNB2,KPNA4,FBN1,NOP14,ATL2,SPCS3,ITGB4,NDFIP1,TBC1D4,DNAJB4,TMEM41B,LDLR,IKBIP,YWHAE,UBE2I,ELMOD2,ANKRD26,CNPY4,PAK1IP1,EXOC2,GPRC5A,NOL8,GALNT7,SON,CBFB,MAK16,ATP8A2,SH3GL1,PRIM1,TRRAP,GGCT,TMED10,PPP2R4,CEP72,PPP2R5C,HNRNPA1,WDR75,ANAPC5,DROSHA,JUP,PRKAA1,HEATR2,APEH,MAN2B1,THBS1,SLC7A11,SCAF1,GLIPR1,ARPC5,CYR61,GNAI2,TMED2,USE1,TM9SF1,SEC11C,VEZT,FXR1,PKM2,DERL1,CAT,ASCC3,KIDINS220,CSNK1G1,GTF3C4,PPP3R1,MPP2,NT5C1B,CNDP2,PLIN3,ESRRA,PLA2G4A,CAST,ADPGK,BCL2L1,RHOF,TWF1,STRN,PPID,ATXN10,SEC23A,CDC123,PTBP1,XPOT,TRIM28,MRPL28,EIF2B1,SLC4A7,KIAA0564,PRPF4B,MLH1,REEP5,PHLDA2,EEF1A1,ABL1,PPP1R10,COPS7B,LARP4B,CSDA,SMCHD1,PNPO,NOTCH1,LIN28A,VAMP3,BMS1,KIF11,EXOSC10,SEC24B,RETSAT,NUCB1,DDX50,MPDU1,REXO1,SERPINB5,DHX36,USP16,UBL3,PTMS,FAF2,MTX3,HDGF,ATRX,RARS2,MTDH,UGDH,ABCB10,LRRC8C,MAP1LC3B,BECN1,NDUFV3,NFU1,LSM1,ITPRIPL2,SLC38A1,TMEM2,PTRH1,RRM2,WDR82,TMEM59,PTGFRN,UTP11L,TMCO1,SMN2,NIP7,FAM96A,LARP4,BAZ1B,TNRC6A,AK2,SERPINE2,PPP1R12A,RBFOX1,KRT85,SCD,SAMD9,XPO7,SLC12A4,LIG3,TIMM10,DTL,C16orf62,EEF2,KCNN4,LIMCH1,PYCR2,NCEH1,ZNF324,SLC12A2,CPSF3L,POLR2B,CSNK1G3,EPT1,ERLIN1,PRDM1,UFM1,FOXD1,SEPT7,EGFR,PEX11B,NAP1L1,UAP1,FSCN1,YWHAZ,PCNT,SOD2,ARG1,CHD1,PAIP1,USP5,WNT5A,SLC38A2,PSME4,RAB34,RPN2,CPSF3,MET,TMEM87A,GNG5,NXT1,NCL,OGDH,RFT1,TOMM5,ANPEP,TIAL1,DARS2,MAPK1,KDELC2,CAMKV,DNAJC2,DNAJA4,TRIP12,SCYL1,SEC62,KIF5B,NOL9,NPR3,DSG2,SAMHD1,FMR1,PNMA2,ELOVL5,TELO2,SYPL1,PGM1,CSNK1G2,UBE2H,EIF2B4,RQCD1,CTSL1,RND3,OSBPL8,C5orf15,MRPS5,NR2F6

KEGG pathways enriched for interacted genes

pathway name

pathway description

target genes enrich in pathway

p-value

hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	ITGA2,ITGB3,ITGB4,DSG2,DAG1,ITGA6,JUP,CDH2,ATP2A2,CTNNB1,	5.64E-4
hsa05130	Pathogenic Escherichia coli infection	TUBB4B,ARPC5,TUBB3,YWHAZ,ABL1,NCL,TUBA1B,CTNNB1,	1.88E-2
hsa04510	Focal adhesion	CAPN2,JUN,ITGA2,EGFR,ITGB3,ITGB4,CTNNB1,IGF1R,PIK3CD,PPP1CC,PPP1R12A,MET,ITGA6,THBS1,MAPK1,	4.06E-2
hsa05210	Colorectal cancer	JUN,IGF1R,PIK3CD,MLH1,EGFR,BAX,MET,CTNNB1,MAPK1,	4.61E-2
hsa05014	Amyotrophic lateral sclerosis (ALS)	DERL1,BCL2L1,MAP2K3,BAX,CAT,PPP3CA,PPP3R1,	5.96E-2

hsa04114	Oocyte meiosis	IGF1R,PPP1CC,PPP2R5C,CDC20,YWHAZ,ANAPC5,YWHAE,MAPK1,PPP3CA,PPP3R1,	7.40E-2
hsa04520	Adherens junction	IGF1R,CTNND1,EGFR,MET,SNAI1,CTNNB1,MAPK1,	3.33E-1
hsa04512	ECM-receptor interaction	ITGA2,ITGB3,ITGB4,DAG1,CD44,ITGA6,THBS1,	4.79E-1
hsa05410	Hypertrophic cardiomyopathy (HCM)	ITGA2,PRKAA1,ITGB3,ITGB4,DAG1,ITGA6,ATP2A2,	5.02E-1
hsa00230	Purine metabolism	NT5C1B,NT5C3,AK2,PAICS,POLR2B,PRIM1,RRM2,NT5E,POLR2C,PKM2,	5.09E-1
hsa05200	Pathways in cancer	JUN,ITGA2,BCL2L1,MLH1,EGFR,BAX,ABL1,JUP,WNT5A,CTNNB1,IGF1R,CDK6,PIK3CD,HDAC1,MET,ITGA6,MAPK1,	5.16E-1
hsa04210	Apoptosis	CAPN2,PIK3CD,BCL2L1,TNFRSF10B,BAX,PPP3CA,PPP3R1,	5.51E-1
hsa04115	p53 signaling pathway	CDK6,TNFRSF10B,BAX,RRM2,SERPINB5,THBS1,	6.17E-1
hsa00480	Glutathione metabolism	GGCT,IDH1,RRM2,MGST2,ANPEP,	7.11E-1
hsa05218	Melanoma	IGF1R,CDK6,PIK3CD,EGFR,MET,MAPK1,	7.16E-1
hsa04810	Regulation of actin cytoskeleton	ARPC5,ITGA2,PIK3CD,PPP1CC,EGFR,PPP1R12A,GNA13,NCKAP1,ITGB3,ITGB4,ITGA6,MAPK1,	7.49E-1
hsa00240	Pyrimidine metabolism	NT5C1B,NT5C3,POLR2B,PRIM1,RRM2,NT5E,POLR2C,	7.77E-1
hsa05213	Endometrial cancer	PIK3CD,MLH1,EGFR,CTNNB1,MAPK1,	7.97E-1
hsa05220	Chronic myeloid leukemia	CDK6,PIK3CD,BCL2L1,HDAC1,ABL1,MAPK1,	8.61E-1
hsa04722	Neurotrophin signaling pathway	JUN,PIK3CD,BAX,YWHAZ,KIDINS220,ABL1,YWHAE,MAPK1,	9.47E-1
hsa04110	Cell cycle	CDK6,CDC20,HDAC1,YWHAZ,ANAPC5,ABL1,YWHAE,PCNA,	9.78E-1

Gene ontology terms enriched for interacted genes

GO terms

GO terms description

target genes enrich in GO term

p-value

GO:0006396	RNA processing	EIF2C2,INTS6,SARS,DROSHA,LSM1,HNRNPA1L2,ZNF638,RBFOX1,RPP40,CPSF4,PES1,LIN28A,CPSF3,RPP14,PRPF19,FRG1,HNRNPA1,CPSF3L,UTP6,PRPF40A,URM1,MBNL1,CPSF1,UTP15,RBM5,HNRNPM,PRPF4B,WDR12,MLH1,RBFOX2,RPS17,SF3B3,UTP11L,PTBP1,NOP14,EXOSC10,C1D,RBMS1,SCAF1,POLR2B,DHX8,POLR2C,SMN2,SMN1,PABPC1,SMAD1,	1.53E-10
GO:0046907	intracellular transport	JUN,STX7,STX16,TIMM10,ATP2A2,SEC23A,RHOB,NAPG,XPO7,TIMM17A,BCL6,USE1,BAX,ATL2,AP2A1,NDE1,TIMM9,MTX3,MAPK1,TMED10,TOM1,XPO1,TAPBP,RAB14,KPNA4,SEC24B,NDEL1,PPP1R10,NXT1,SCYL1,HNRNPA1,GABARAPL2,PCNA,AP2S1,AP3S1,SEC24A,KIF5B,TOMM5,KPNA1,BCL2L1,PPP3CA,TIMM8A,DERL1,GRPEL2,SDCBP,YWHAZ,SEC62,YWHAE,XPOT,	5.63E-10
GO:0034613	cellular protein localization	JUN,XPO1,TOM1,EGFR,STX7,STX16,TIMM10,KPNA4,SEC24B,CTNNB1,PPP1R10,SEC23A,NXT1,NAPG,TIMM17A,XPO7,PCNA,AP2S1,BCL6,AP3S1,SEC24A,TOMM5,PTPRK,KPNA1,BAX,PPP3CA,TIMM8A,DERL1,GRPEL2,SDCBP,AP2A1,YWHAZ,SEC62,TIMM9,YWHAE,MTX3,MAPK1,	8.27E-10
GO:0070727	cellular macromolecule localization	JUN,XPO1,TOM1,EGFR,STX7,STX16,TIMM10,KPNA4,SEC24B,CTNNB1,PPP1R10,SEC23A,NXT1,NAPG,TIMM17A,XPO7,PCNA,AP2S1,BCL6,AP3S1,SEC24A,TOMM5,PTPRK,KPNA1,BAX,PPP3CA,TIMM8A,DERL1,GRPEL2,SDCBP,AP2A1,YWHAZ,SEC62,TIMM9,YWHAE,MTX3,MAPK1,	1.00E-9
GO:0006886	intracellular protein transport	JUN,XPO1,TOM1,STX7,STX16,TIMM10,KPNA4,SEC24B,PPP1R10,SEC23A,NXT1,NAPG,TIMM17A,XPO7,PCNA,AP2S1,AP3S1,BCL6,SEC24A,TOMM5,KPNA1,PPP3CA,TIMM8A,DERL1,GRPEL2,SDCBP,AP2A1,YWHAZ,SEC62,TIMM9,YWHAE,MTX3,MAPK1,	1.32E-8

GO:0045184	establishment of protein localization	JUN,TMED10,TNPO3,TOM1,XPO1,RAB34,STX7,STX16,ARF6,RAB21,RAB14,TIMM10,KPNA4,TMED2,SEC24B,PPP1R10,SEC23A,RHOB,NXT1,NAPG,TMED3,GABARAPL2,TIMM17A,XPO7,PCNA,AP2S1,BCL6,AP3S1,SEC24A,USE1,TOMM5,EXOC2,ITGA2,KPNA1,PPP3CA,TIMM8A,DERL1,GRPEL2,SDCBP,SNX3,AP2A1,RAB27B,YWHAZ,SEC62,YWHAE,TIMM9,MTX3,MAPK1,	2.22E-7
GO:0008104	protein localization	JUN,STX7,RAB34,STX16,ARF6,TIMM10,TMED2,SEC23A,RHOB,NAPG,TIMM17A,XPO7,BCL6,USE1,PTPRK,BAX,SNX3,AP2A1,RAB27B,TIMM9,MTX3,MAPK1,TMED10,TNPO3,TOM1,XPO1,EGFR,RAB21,KPNA4,RAB14,CTNNB1,SEC24B,PPP1R10,NXT1,TMED3,GABARAPL2,PCNA,AP2S1,AP3S1,SEC24A,TOMM5,ITGA2,EXOC2,KPNA1,PPP3CA,TIMM8A,DERL1,GRPEL2,SDCBP,YWHAZ,SEC62,YWHAE,	3.57E-7
GO:0015031	protein transport	JUN,TMED10,TNPO3,TOM1,XPO1,RAB34,STX7,STX16,ARF6,RAB21,RAB14,TIMM10,KPNA4,TMED2,SEC24B,PPP1R10,SEC23A,RHOB,NXT1,NAPG,TMED3,GABARAPL2,TIMM17A,XPO7,PCNA,AP2S1,BCL6,AP3S1,SEC24A,USE1,TOMM5,EXOC2,KPNA1,PPP3CA,TIMM8A,DERL1,GRPEL2,SDCBP,SNX3,AP2A1,RAB27B,YWHAZ,SEC62,TIMM9,YWHAE,MTX3,MAPK1,	4.31E-7
GO:0017038	protein import	JUN,TOMM5,KPNA1,XPO1,KPNA4,TIMM10,PPP3CA,TIMM8A,PPP1R10,GRPEL2,YWHAZ,TIMM17A,TIMM9,XPO7,MTX3,BCL6,MAPK1,	6.24E-7
GO:0065003	macromolecular complex assembly	SEPT7,XPO1,RRM2,TAPBP,VAMP3,NDUFAF1,CAT,DAG1,JUP,CTNNB1,BMS1,PICALM,IGF1R,TUBB4B,TUBB3,NAPG,MKI67IP,XPO7,AP2S1,MBNL1,GTF3C4,RBM5,SOD2,MLH1,NAP1L1,BAX,SLC9A3R2,NIP7,SF3B3,TUBA1B,ATL2,GTF2H2,GTF2H1,HIST1H1A,SLC7A6,TGM2,POLR2B,GTF2H2C,POLR2C,USP16,SMN2,SMN1,SMAD1,CDH2,	1.13E-6
GO:0070271	protein complex biogenesis	SEPT7,XPO1,RRM2,TAPBP,NDUFAF1,VAMP3,CAT,DAG1,JUP,CTNNB1,PICALM,IGF1R,TUBB4B,TUBB3,NAPG,MKI67IP,XPO7,AP2S1,GTF3C4,SOD2,MLH1,BAX,SLC9A3R2,SF3B3,TUBA1B,ATL2,GTF2H2,GTF2H1,SLC7A6,TGM2,POLR2B,GTF2H2C,POLR2C,USP16,SMAD1,CDH2,	1.44E-6
GO:0006461	protein complex assembly	SEPT7,XPO1,RRM2,TAPBP,NDUFAF1,VAMP3,CAT,DAG1,JUP,CTNNB1,PICALM,IGF1R,TUBB4B,TUBB3,NAPG,MKI67IP,XPO7,AP2S1,GTF3C4,SOD2,MLH1,BAX,SLC9A3R2,SF3B3,TUBA1B,ATL2,GTF2H2,GTF2H1,SLC7A6,TGM2,POLR2B,GTF2H2C,POLR2C,USP16,SMAD1,CDH2,	1.44E-6
GO:0034660	ncRNA metabolic process	DARS2,UTP15,WDR12,INTS6,SARS,DROSHA,RPS17,RPP40,UTP11L,PES1,CARS,LIN28A,NOP14,RPP14,EXOSC10,C1D,FRG1,CPSF3L,UTP6,RARS2,MKI67IP,URM1,	1.58E-6
GO:0006605	protein targeting	JUN,TOMM5,KPNA1,XPO1,KPNA4,TIMM10,PPP3CA,TIMM8A,PPP1R10,GRPEL2,NXT1,SDCBP,YWHAZ,SEC62,TIMM17A,TIMM9,YWHAE,XPO7,MTX3,BCL6,MAPK1,	2.09E-6
GO:0033365	protein localization in organelle	JUN,TOMM5,KPNA1,XPO1,KPNA4,TIMM10,PPP3CA,TIMM8A,PPP1R10,GRPEL2,YWHAZ,TIMM17A,TIMM9,XPO7,MTX3,BCL6,MAPK1,	2.68E-6
GO:0034470	ncRNA processing	UTP15,WDR12,EIF2C2,SARS,INTS6,RPS17,RPP40,UTP11L,PES1,LIN28A,NOP14,RPP14,EXOSC10,C1D,FRG1,CPSF3L,UTP6,URM1,SMAD1,	4.20E-6
GO:0043933	macromolecular complex subunit organization	SEPT7,XPO1,RRM2,TAPBP,VAMP3,NDUFAF1,CAT,DAG1,JUP,CTNNB1,BMS1,PICALM,IGF1R,TUBB4B,TUBB3,NAPG,MKI67IP,XPO7,AP2S1,MBNL1,GTF3C4,RBM5,SOD2,MLH1,NAP1L1,BAX,SLC9A3R2,NIP7,SF3B3,TUBA1B,ATL2,GTF2H2,GTF2H1,HIST1H1A,SLC7A6,TGM2,POLR2B,GTF2H2C,POLR2C,USP16,SMN2,SMN1,SMAD1,CDH2,	5.78E-6
GO:0006397	mRNA processing	EIF2C2,LSM1,HNRNPA1L2,RBFOX1,CPSF4,CPSF3,PRPF19,FRG1,HNRNPA1,PRPF40A,MBNL1,CPSF1,PRPF4B,HNRNPM,RBM5,MLH1,RBFOX2,SF3B3,PTBP1,SCAF1,POLR2B,POLR2C,DHX8,SMN2,SMN1,PABPC1,	9.58E-6
GO:0016192	vesicle-mediated transport	TMED10,TOM1,RAB34,STX7,PLIN3,STX16,TAPBP,VAMP3,ARF6,RAB14,PDLIM7,TMED2,SEC24B,CTNNB1,PICALM,LDLR,SEC23A,RHOB,SCYL1,NAPG,GABARAPL2,AP2S1,ZFPL1,AP3S1,SEC24A,USE1,EXOC2,SH3GL1,ATL2,GTF2H2,ELMOD2,SNX3,AP2A1,YWHAZ,GTF2H2C,CORO1C,THBS1,	9.96E-6
GO:0016071	mRNA metabolic process	EIF2C2,LSM1,HNRNPA1L2,RBFOX1,CPSF4,CPSF3,PRPF19,FRG1,HNRNPA1,PRPF40A,MBNL1,CPSF1,RBM5,PRPF4B,HNRNPM,MLH1,RBFOX2,SF3B3,PTBP1,EXOSC10,SCAF1,PAIP1,POLR2B,POLR2C,DHX8,SMN2,SMN1,PABPC1,	1.23E-5
GO:0008380	RNA splicing	RBM5,HNRNPM,PRPF4B,RBFOX2,LSM1,HNRNPA1L2,ZNF638,RBFOX1,SF3B3,CPSF3,PTBP1,PRPF19,FRG1,HNRNPA1,SCAF1,POLR2B,DHX8,POLR2C,SMN2,PRPF40A,SMN1,PABPC1,MBNL1,CPSF1,	1.29E-5
GO:0016044	membrane organization	TOM1,EGFR,RAB34,STX7,KCNN4,VAMP3,TIMM10,PDLIM7,SEC24B,PICALM,NDEL1,LDLR,SEC23A,NAPG,AP2S1,SEC24A,BCL2L1,SH3GL1,BAX,TIMM8A,GTF2H2,ELMOD2,SNX3,AP2A1,GTF2H2C,TIMM9,CORO1C,THBS1,	2.06E-5
GO:0070585	protein localization in mitochondrion	TIMM8A,TOMM5,GRPEL2,YWHAZ,TIMM17A,TIMM9,MTX3,TIMM10,	3.23E-5
GO:0006626	protein targeting to mitochondrion	TIMM8A,TOMM5,GRPEL2,YWHAZ,TIMM17A,TIMM9,MTX3,TIMM10,	3.23E-5
GO:0016072	rRNA metabolic process	UTP15,EXOSC10,C1D,FRG1,WDR12,UTP6,MKI67IP,DROSHA,RPS17,UTP11L,PES1,NOP14,	6.53E-5
GO:0048193	Golgi vesicle transport	USE1,TMED10,STX7,STX16,TAPBP,RAB14,SEC24B,ATL2,SEC23A,SCYL1,NAPG,AP2A1,GABARAPL2,SEC24A,	6.64E-5
GO:0006839	mitochondrial transport	TIMM8A,TOMM5,GRPEL2,BCL2L1,BAX,YWHAZ,TIMM17A,TIMM9,MTX3,TIMM10,	1.09E-4
GO:0042254	ribosome biogenesis	UTP15,WDR12,DROSHA,RPS17,NIP7,UTP11L,PES1,NOP14,BMS1,EXOSC10,C1D,FRG1,UTP6,	1.37E-4
GO:0022613	ribonucleoprotein complex biogenesis	UTP15,RBM5,WDR12,DROSHA,RPS17,NIP7,UTP11L,PES1,NOP14,BMS1,EXOSC10,C1D,FRG1,UTP6,SMN2,SMN1,MBNL1,	1.39E-4
GO:0007005	mitochondrion organization	JUN,TOMM5,SOD2,BCL2L1,BAX,TIMM10,TIMM8A,GRPEL2,YWHAZ,GGCT,TIMM9,TIMM17A,MTX3,	4.34E-4
GO:0051170	nuclear import	JUN,PPP1R10,KPNA1,HNRNPA1,XPO1,XPO7,BCL6,KPNA4,MAPK1,PPP3CA,	7.00E-4
GO:0006364	rRNA processing	UTP15,EXOSC10,C1D,FRG1,WDR12,UTP6,RPS17,UTP11L,PES1,NOP14,	9.67E-4
GO:0001836	release of cytochrome c from mitochondria	JUN,SOD2,BCL2L1,BAX,GGCT,	2.34E-2
GO:0006606	protein import into nucleus	JUN,PPP1R10,KPNA1,XPO1,XPO7,BCL6,KPNA4,MAPK1,PPP3CA,	2.52E-2
GO:0006913	nucleocytoplasmic transport	JUN,PPP1R10,NXT1,KPNA1,HNRNPA1,XPO1,XPO7,BCL6,XPOT,KPNA4,MAPK1,PPP3CA,	3.98E-2
GO:0051169	nuclear transport	JUN,PPP1R10,NXT1,KPNA1,HNRNPA1,XPO1,XPO7,BCL6,XPOT,KPNA4,MAPK1,PPP3CA,	4.38E-2
GO:0034504	protein localization in nucleus	JUN,PPP1R10,KPNA1,XPO1,XPO7,BCL6,KPNA4,MAPK1,PPP3CA,	4.38E-2
GO:0000018	regulation of DNA recombination	MRE11A,KPNA1,MLH1,NDFIP1,BCL6,	5.25E-2
GO:0010608	posttranscriptional regulation of gene expression	GATC,ITGA2,EIF2C2,EIF2B1,EIF1,LIN28A,NAPG,EIF2B4,TNRC6A,PAIP1,PABPC1,SMAD1,THBS1,MAPK1,	5.75E-2
GO:0031123	RNA 3'-end processing	MLH1,LIN28A,PABPC1,CPSF3,CPSF1,	6.04E-2
GO:0006091	generation of precursor metabolites and energy	HK1,SOD2,ME3,ADPGK,NDUFAF1,CAT,GLRX,NDUFV3,FDX1,TPI1,OGDH,SUCLA2,PPP1CC,IDH1,PGM1,PKM2,ATP6V1B2,ATP6V1C1,	6.17E-2
GO:0045667	regulation of osteoblast differentiation	RUNX2,CDK6,ESRRA,SMAD1,CTNNB1,PDLIM7,	6.31E-2
GO:0009628	response to abiotic stimulus	JUN,CSDA,ITGA2,PTPRK,SOD2,EIF2B1,BCL2L1,NR2F6,PLA2G4A,SLC12A2,EGFR,BAX,CAT,GTF2H2,TUBB3,EIF2B4,CIRBP,MAT2A,GTF2H2C,DNAJB4,THBS1,	6.66E-2
GO:0009266	response to temperature stimulus	CSDA,EIF2B1,PLA2G4A,NR2F6,EIF2B4,CIRBP,DNAJB4,THBS1,	7.89E-2
GO:0051259	protein oligomerization	ATL2,IGF1R,SEPT7,TGM2,SOD2,BAX,RRM2,USP16,CAT,JUP,CDH2,CTNNB1,	8.89E-2
GO:0031124	mRNA 3'-end processing	MLH1,PABPC1,CPSF3,CPSF1,	8.91E-2
GO:0006096	glycolysis	HK1,TPI1,OGDH,PGM1,ADPGK,PKM2,	9.20E-2
GO:0051789	response to protein stimulus	DERL1,ITGA2,CYR61,DNAJA1,BCL2L1,DNAJB1,DNAJB4,DNAJC3,ERP44,	9.45E-2
GO:0010033	response to organic substance	JUN,EIF2C2,EGFR,GNG5,DNAJB1,DNAJC3,CD44,PPP2R2A,LIN28A,CTNNB1,LDLR,IGF1R,EIF2B4,GNG2,NEUROD1,IDH1,ERP44,AP3S1,ITGA2,DNAJA1,EIF2B1,BCL2L1,PLA2G4A,PPP3CA,DERL1,CYR61,MAT2A,ACP2,DNAJB4,THBS1,SMAD1,MAPK1,	9.54E-2
GO:0000398	nuclear mRNA splicing, via spliceosome	RBM5,HNRNPM,HNRNPA1,POLR2B,POLR2C,SF3B3,SMN2,SMN1,CPSF3,MBNL1,PTBP1,CPSF1,	9.89E-2
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	RBM5,HNRNPM,HNRNPA1,POLR2B,POLR2C,SF3B3,SMN2,SMN1,CPSF3,MBNL1,PTBP1,CPSF1,	9.89E-2
GO:0000375	RNA splicing, via transesterification reactions	RBM5,HNRNPM,HNRNPA1,POLR2B,POLR2C,SF3B3,SMN2,SMN1,CPSF3,MBNL1,PTBP1,CPSF1,	9.89E-2
GO:0008637	apoptotic mitochondrial changes	JUN,SOD2,BCL2L1,BAX,GGCT,	9.93E-2

KEGG pathways and Gene Ontology terms enriched for the interacted genes of ncRNA from RAID and miRTarBase.

disease name	related genes	p-value