ncRNADetailInformation

Detail Information
Functional analysis

miRNA name

pre-miRNA

family

pre-miRNA Sequence

mature-miRNA

mature sequence

pre-miRNA description

miR-195-5p

MI0000489

MIPF0000006

AGCUUCCCUGGCUCUAGCAGCACAGAAAUAUUGGCACAGGGAAGCGAGUCUGCCAAUAUUGGCUGUGCUGCUCCAGGCAGGGUGGUG

MIMAT0000461

hsa-miR-195-5p

UAGCAGCACAGAAAUAUUGGC

This miRNA sequence is predicted based on homology to a verified miRNAfrom mouse , later verified in human .

link to database

TargetScanS 6.2 | MicroCosm | microRNA.org | miRNAMap 2.0

Interacted genes from RAID,miRTarBase

SKI,BACE1,CDK4,VEGFA,RUNX2,TAB3,RPL10,RAF1,MECP2,CDC42,SPTBN1,LSM11,CCND1,KRT7,SIRT1
more » SKI,BACE1,CDK4,VEGFA,RUNX2,TAB3,RPL10,RAF1,MECP2,CDC42,SPTBN1,LSM11,CCND1,KRT7,SIRT1,CHUK,ZNF280C,ARL2,CCND3,BCL2L2,BCL2,SLC2A3,CAND1,MBD1,CAMKV,EIF2C1,CCNE1,CCL4,COPB1,E2F3,AGER,ABCB7,SH3BGRL2,BCL2L11,CAB39,TBCCD1,TMC6,WEE1,CDK6,TPI1,CHEK1,NOLC1

KEGG pathways enriched for interacted genes

pathway name

pathway description

target genes enrich in pathway

p-value

hsa05212	Pancreatic cancer	CCND1,CDK6,CHUK,VEGFA,RAF1,CDK4,E2F3,CDC42,	5.67E-9
hsa04110	Cell cycle	CCND1,CDK6,CHEK1,CDK4,WEE1,CCNE1,E2F3,CCND3,	2.72E-7
hsa05222	Small cell lung cancer	CCND1,CDK6,BCL2,CHUK,CDK4,CCNE1,E2F3,	5.46E-7
hsa05200	Pathways in cancer	CCND1,CDK6,BCL2,CHUK,VEGFA,RAF1,CDK4,CCNE1,E2F3,CDC42,	1.54E-6
hsa04115	p53 signaling pathway	CCND1,CDK6,CHEK1,CDK4,CCNE1,CCND3,	4.89E-6

hsa05220	Chronic myeloid leukemia	CCND1,CDK6,CHUK,RAF1,CDK4,E2F3,	7.95E-6
hsa05219	Bladder cancer	CCND1,VEGFA,RAF1,CDK4,E2F3,	1.77E-5
hsa05215	Prostate cancer	CCND1,BCL2,CHUK,RAF1,CCNE1,E2F3,	1.84E-5
hsa05223	Non-small cell lung cancer	CCND1,CDK6,RAF1,CDK4,E2F3,	4.85E-5
hsa05214	Glioma	CCND1,CDK6,RAF1,CDK4,E2F3,	8.93E-5
hsa05218	Melanoma	CCND1,CDK6,RAF1,CDK4,E2F3,	1.42E-4
hsa04510	Focal adhesion	CCND1,BCL2,VEGFA,RAF1,CDC42,CCND3,	8.75E-4
hsa04062	Chemokine signaling pathway	CCL4,CHUK,RAF1,CDC42,JAK2,	5.40E-2
hsa04660	T cell receptor signaling pathway	CHUK,RAF1,CDK4,CDC42,	8.16E-2
hsa05221	Acute myeloid leukemia	CCND1,CHUK,RAF1,	2.12E-1
hsa05211	Renal cell carcinoma	VEGFA,RAF1,CDC42,	3.02E-1
hsa04370	VEGF signaling pathway	VEGFA,RAF1,CDC42,	3.43E-1
hsa05210	Colorectal cancer	CCND1,BCL2,RAF1,	4.22E-1
hsa04722	Neurotrophin signaling pathway	BCL2,RAF1,CDC42,	8.42E-1

Gene ontology terms enriched for interacted genes

GO terms

GO terms description

target genes enrich in GO term

p-value

GO:0051325	interphase	CCND1,CDK6,BCL2,CHEK1,CDK4,KRT7,CCNE1,	4.51E-7
GO:0008406	gonad development	CCND1,BCL2,BCL2L2,VEGFA,BCL2L11,CCNE1,SIRT1,	6.26E-7
GO:0048608	reproductive structure development	CCND1,BCL2,BCL2L2,VEGFA,BCL2L11,CCNE1,SIRT1,	1.25E-6
GO:0045137	development of primary sexual characteristics	CCND1,BCL2,BCL2L2,VEGFA,BCL2L11,CCNE1,SIRT1,	1.31E-6
GO:0007548	sex differentiation	CCND1,BCL2,BCL2L2,VEGFA,BCL2L11,CCNE1,SIRT1,	3.59E-6

GO:0007049	cell cycle	CCND1,CDK6,BCL2,CHEK1,CDK4,WEE1,ARL2,KRT7,NOLC1,CCNE1,E2F3,CCND3,	5.94E-6
GO:0042127	regulation of cell proliferation	CCND1,RUNX2,CDK6,BCL2,VEGFA,CHEK1,CDK4,AGER,SKI,E2F3,SIRT1,JAK2,	6.80E-6
GO:0051329	interphase of mitotic cell cycle	CCND1,CDK6,BCL2,CHEK1,CDK4,CCNE1,	9.53E-6
GO:0006468	protein amino acid phosphorylation	CCND1,CDK6,CAMKV,BCL2,CHUK,RAF1,SPTBN1,CHEK1,CDK4,WEE1,JAK2,	1.06E-5
GO:0008284	positive regulation of cell proliferation	CCND1,RUNX2,CDK6,BCL2,VEGFA,CDK4,AGER,E2F3,JAK2,	1.56E-5
GO:0022403	cell cycle phase	CCND1,CDK6,BCL2,CHEK1,CDK4,WEE1,KRT7,NOLC1,CCNE1,	1.56E-5
GO:0016310	phosphorylation	CCND1,CDK6,CAMKV,BCL2,CHUK,RAF1,SPTBN1,CHEK1,CDK4,WEE1,JAK2,	5.13E-5
GO:0000278	mitotic cell cycle	CCND1,CDK6,BCL2,CHEK1,CDK4,WEE1,NOLC1,CCNE1,	6.56E-5
GO:0048534	hemopoietic or lymphoid organ development	CDK6,BCL2,CHUK,VEGFA,BCL2L11,CDC42,JAK2,	7.83E-5
GO:0003006	reproductive developmental process	CCND1,BCL2,BCL2L2,VEGFA,BCL2L11,CCNE1,SIRT1,	8.17E-5
GO:0002520	immune system development	CDK6,BCL2,CHUK,VEGFA,BCL2L11,CDC42,JAK2,	1.08E-4
GO:0022402	cell cycle process	CCND1,CDK6,BCL2,CHEK1,CDK4,WEE1,KRT7,NOLC1,CCNE1,	1.41E-4
GO:0051301	cell division	CCND1,CDK6,CDK4,WEE1,CCNE1,CDC42,CCND3,	1.56E-4
GO:0006793	phosphorus metabolic process	CCND1,CDK6,CAMKV,BCL2,CHUK,RAF1,SPTBN1,CHEK1,CDK4,WEE1,JAK2,	2.61E-4
GO:0006796	phosphate metabolic process	CCND1,CDK6,CAMKV,BCL2,CHUK,RAF1,SPTBN1,CHEK1,CDK4,WEE1,JAK2,	2.61E-4
GO:0051726	regulation of cell cycle	CCND1,CDK6,BCL2,CHEK1,CDK4,CDC42,CCND3,	2.92E-4
GO:0008584	male gonad development	CCND1,BCL2,BCL2L2,BCL2L11,	4.10E-4
GO:0048511	rhythmic process	BCL2,VEGFA,CDK4,CCNE1,SIRT1,	4.39E-4
GO:0010604	positive regulation of macromolecule metabolic process	CCND1,RUNX2,BCL2,VEGFA,CDK4,CCNE1,E2F3,CAND1,CCND3,JAK2,	4.84E-4
GO:0030097	hemopoiesis	CDK6,BCL2,CHUK,VEGFA,CDC42,JAK2,	4.85E-4
GO:0000082	G1/S transition of mitotic cell cycle	CCND1,BCL2,CDK4,CCNE1,	5.11E-4
GO:0022602	ovulation cycle process	BCL2,VEGFA,CCNE1,SIRT1,	6.89E-4
GO:0008585	female gonad development	BCL2,VEGFA,CCNE1,SIRT1,	7.56E-4
GO:0046546	development of primary male sexual characteristics	CCND1,BCL2,BCL2L2,BCL2L11,	7.92E-4
GO:0042698	ovulation cycle	BCL2,VEGFA,CCNE1,SIRT1,	8.65E-4
GO:0051412	response to corticosterone stimulus	CCND1,BCL2,CCNE1,	8.99E-4
GO:0046660	female sex differentiation	BCL2,VEGFA,CCNE1,SIRT1,	9.42E-4
GO:0031099	regeneration	CCND1,BCL2,CCNE1,JAK2,	9.42E-4
GO:0046545	development of primary female sexual characteristics	BCL2,VEGFA,CCNE1,SIRT1,	9.42E-4
GO:0046661	male sex differentiation	CCND1,BCL2,BCL2L2,BCL2L11,	1.11E-2
GO:0030278	regulation of ossification	RUNX2,CDK6,BCL2,SKI,	1.34E-2
GO:0051385	response to mineralocorticoid stimulus	CCND1,BCL2,CCNE1,	1.41E-2
GO:0032268	regulation of cellular protein metabolic process	CCND1,BCL2,EIF2C1,CDK4,KRT7,CCND3,JAK2,	1.90E-2
GO:0001934	positive regulation of protein amino acid phosphorylation	CCND1,BCL2,CCND3,JAK2,	1.96E-2
GO:0032504	multicellular organism reproduction	BCL2,BCL2L2,VEGFA,CHEK1,BCL2L11,CCNE1,SIRT1,	2.18E-2
GO:0048609	reproductive process in a multicellular organism	BCL2,BCL2L2,VEGFA,CHEK1,BCL2L11,CCNE1,SIRT1,	2.18E-2
GO:0030099	myeloid cell differentiation	CHUK,VEGFA,CDC42,JAK2,	2.22E-2
GO:0042327	positive regulation of phosphorylation	CCND1,BCL2,CCND3,JAK2,	2.51E-2
GO:0040017	positive regulation of locomotion	BCL2,VEGFA,AGER,JAK2,	2.58E-2
GO:0045937	positive regulation of phosphate metabolic process	CCND1,BCL2,CCND3,JAK2,	2.74E-2
GO:0010562	positive regulation of phosphorus metabolic process	CCND1,BCL2,CCND3,JAK2,	2.74E-2
GO:0010608	posttranscriptional regulation of gene expression	BCL2,VEGFA,EIF2C1,CDK4,KRT7,	2.80E-2
GO:0032270	positive regulation of cellular protein metabolic process	CCND1,BCL2,CDK4,CCND3,JAK2,	3.99E-2
GO:0051247	positive regulation of protein metabolic process	CCND1,BCL2,CDK4,CCND3,JAK2,	4.64E-2
GO:0033197	response to vitamin E	CCND1,CCNE1,	5.61E-2
GO:0001541	ovarian follicle development	BCL2,VEGFA,CCNE1,	5.88E-2
GO:0045667	regulation of osteoblast differentiation	RUNX2,CDK6,SKI,	6.45E-2
GO:0051098	regulation of binding	BCL2,SKI,SIRT1,JAK2,	8.95E-2
GO:0042325	regulation of phosphorylation	CCND1,BCL2,CHEK1,CDC42,CCND3,JAK2,	9.33E-2
GO:0000079	regulation of cyclin-dependent protein kinase activity	CCND1,CHEK1,CCND3,	1.00E-1

KEGG pathways and Gene Ontology terms enriched for the interacted genes of ncRNA from RAID and miRTarBase.

disease name	related genes	p-value