ncRNADetailInformation

Detail Information
Functional analysis

miRNA name

pre-miRNA

family

pre-miRNA Sequence

mature-miRNA

mature sequence

pre-miRNA description

miR-186

MI0000483	MIPF0000109	UGCUUGUAACUUUCCAAAGAAUUCUCCUUUUGGGCUUUCUGGUUUUAUUUUAAGCCCAAAGGUGAAUUUUUUGGGAAGUUUGAGCU	MIMAT0000456 hsa-miR-186-5p	CAAAGAAUUCUCCUUUUGGGCU	This miRNA sequence is predicted based on homology to a verified miRNAfrom mouse. Expression of this miRNA was also verified in a humanosteoblast sarcoma cell line . The mature sequence shown hererepresents the most commonly cloned form from large-scale cloning studies.
MI0000483	MIPF0000109	UGCUUGUAACUUUCCAAAGAAUUCUCCUUUUGGGCUUUCUGGUUUUAUUUUAAGCCCAAAGGUGAAUUUUUUGGGAAGUUUGAGCU	MIMAT0004612 hsa-miR-186-3p	GCCCAAAGGUGAAUUUUUUGGG	This miRNA sequence is predicted based on homology to a verified miRNAfrom mouse. Expression of this miRNA was also verified in a humanosteoblast sarcoma cell line . The mature sequence shown hererepresents the most commonly cloned form from large-scale cloning studies.
MI0000483	MIPF0000109	UGCUUGUAACUUUCCAAAGAAUUCUCCUUUUGGGCUUUCUGGUUUUAUUUUAAGCCCAAAGGUGAAUUUUUUGGGAAGUUUGAGCU	MIMAT0000456 hsa-miR-186-5p	CAAAGAAUUCUCCUUUUGGGCU	This miRNA sequence is predicted based on homology to a verified miRNAfrom mouse. Expression of this miRNA was also verified in a humanosteoblast sarcoma cell line . The mature sequence shown hererepresents the most commonly cloned form from large-scale cloning studies.
MI0000483	MIPF0000109	UGCUUGUAACUUUCCAAAGAAUUCUCCUUUUGGGCUUUCUGGUUUUAUUUUAAGCCCAAAGGUGAAUUUUUUGGGAAGUUUGAGCU	MIMAT0004612 hsa-miR-186-3p	GCCCAAAGGUGAAUUUUUUGGG	This miRNA sequence is predicted based on homology to a verified miRNAfrom mouse. Expression of this miRNA was also verified in a humanosteoblast sarcoma cell line . The mature sequence shown hererepresents the most commonly cloned form from large-scale cloning studies.
MI0000483	MIPF0000109	UGCUUGUAACUUUCCAAAGAAUUCUCCUUUUGGGCUUUCUGGUUUUAUUUUAAGCCCAAAGGUGAAUUUUUUGGGAAGUUUGAGCU	MIMAT0000456 hsa-miR-186-5p	CAAAGAAUUCUCCUUUUGGGCU	This miRNA sequence is predicted based on homology to a verified miRNAfrom mouse. Expression of this miRNA was also verified in a humanosteoblast sarcoma cell line . The mature sequence shown hererepresents the most commonly cloned form from large-scale cloning studies.

link to database

TargetScanS 6.2 | MicroCosm | microRNA.org | miRNAMap 2.0

Interacted genes from RAID,miRTarBase

DCAF16,THOC5,TGOLN2,HMOX2,ZC3H15,LIMA1,INPP5F,LRRFIP1,NMT1,CYTB,GATAD2B,FOXK1,AMZ1,BDP1,RAPH1
more » DCAF16,THOC5,TGOLN2,HMOX2,ZC3H15,LIMA1,INPP5F,LRRFIP1,NMT1,CYTB,GATAD2B,FOXK1,AMZ1,BDP1,RAPH1,FASN,MAP7D1,ELK1,TEX15,TSR1,KPNA1,TRAP1,ZMAT2,NCAPD2,AHCTF1,VDAC3,SEPT11,MLL2,PTPN9,HSP90AB1,POLR2D,MAT2A,FBXL5,TUBB,ITPKB,FUNDC2,SRSF6,HMGCS1,HUWE1,ZFP36L2,NID1,NSD1,AEN,YWHAH,KIAA1462,RBM8A,NENF,JUND,EIF5,VPS13B,DBN1,ITM2B,AKR1A1,RALA,ZNF80,FOXO1,RPL5,RNASEH1,DPYSL5,AMD1,TTC35,ZNF652,SNRNP35,TARDBP,KDM3B,MINK1,PDAP1,DDX21,PCGF1,CACNB1,PGAM1,ZBTB33,PSME1,CD2AP,RPL9,HNRNPA1,BHLHE41,PIGG,PLEKHH2,MED15,ZBTB34,ZBTB4,RAF1,RBM12B,KIAA1826,HNRNPC,SERP1,SUPT16H,FAHD2A,DEPDC1,ACOT12,ABT1,VAV3,KIF11,CBX3,SEC24B,FGFR2,WDR62,DDB1,PPP4R2,UBL3,ERCC3,ACTL8,UBE2Q1,BBS10,CCT4,HNRNPU,MLL3,PRPSAP1,CCT6A,PRR3,TLN1,AKAP11,ZNF629,C5orf41,MYO19,DEK,EIF2A,PIP4K2B,BICD1,CSAG1,TSEN15,PSMA2,ZNF805,ACVR2A,SOAT1,ANTXR2,RFK,RBM27,STAG2,ATXN1,DUS3L,DARS2,FAM117B,KIF5B,COX1,CRAMP1L,SP1,DAGLB,ARRB1,TMEM11,DOCK3,AMBRA1,SPECC1,PLEKHM3,RBM28,WDR11,PSMD13,ANO3,GNG12,HIST1H1E,WNK1,TTI2,FOXN2,SF1,COX3,MATR3,WDR33,STK25,SPRED2,MYSM1,CAMSAP3,RNF6,RNF167,TMBIM6,LDHB,ARHGAP39,QRICH1,FAM59A,PTPMT1,NCAPD3,RSRC2,MRFAP1,TRIM2,THOC1,PPARGC1B,PPP1R15B,CSNK2A1,RAN,GMFB,KIAA0528,NUPL2,RNF40,EIF4G2,G2E3,CBX1,H1F0,ATP1B3,GGPS1,CAD,ZNF295,ZNF793,RNF2,SPTLC1,CLPTM1,RPL29,ARL5B,KIAA0020,PSMD3,TRAPPC10,KRT3,EIF1,BUB1,ECHS1,DNASE2,GOLGA7,ZNF214,ATL2,RPL4,PPCS,ACVR1,NDUFB6,DUSP8,DLC1,PLXNA1,DIEXF,NKAP,RNF111,RRP1B,ANKRD17,IGF2BP3,RNF149,LLGL1,CTPS,LPCAT1,EEF1D,TRIP10,TNPO2,PUM1,C17orf70,KIAA1804,MDN1,SRPK1,PRPF8,FIBP,CNOT6L,TEF,ILF3,ECH1,KHSRP,C18orf32,RBM10,CLDN9,RRM2,UTP11L,BCL11B,CHST11,XPO7,UBXN6,CAND1,CBR1,ZFP90,METTL21A,KCTD15,CHTOP,RLIM,TES,RPL18A,EIF3G,MRPL42,EIF2C1,FAM134A,RPL27,BEND5,PLXNB2,SRSF3,AP1G1,PTP4A1,SLC25A13,RPL7L1,RPS21,SRRM2,C7orf60,G3BP1,PSMD9,RIMS3,MYLIP,ZNF385A,SRSF11,MTA2,SSR2,RBM5,GRIK5,PTTG1,PEG10,DLG3,CRNKL1,DSP,ATL3,RPS4X,RPS7,PSMD2,XRN2,RAG1,NXN,SMARCC2,ATP6,MSL3,GLUL,SRSF2,ANKRD11,ACAA2,PPRC1,SEPT9,HIST1H2BK,NGLY1,CLK1,RAB6A,SPIRE1,NUDT13,SCRIB,RPL36,COX17,TM9SF3,P2RX7,ITSN2,TMEM64,SMAD4,UNK,EIF2C2,ERI2,LBR,TLE4,ABCF2,TUFM,RNPEP,CEP192,LUZP1,TEX261,FIZ1,FRS2,CLDN23,GNAI1,LBP,BTF3,NRP1,DHPS,CNBP,ULK1,PDCD5,MESDC2,FAM192A,CNOT4,MTSS1L,SPEN,C1orf21,CEBPG,PLIN3,SLC15A4,KIF3C,RIMS4,CD46,KIT,COG2,SETD7,ANKZF1,BEND3,PPAPDC1A,CKAP5,NDUFA2,BTF3L4,FEM1B,KIAA1797,PTPN13,YES1,RPL32,ORC5,EIF3C,YARS,STARD8,STK35,BRD1,ST3GAL5,SMN2,ZC3H8,EEF2,TARSL2,PCDH10,SLTM,TUBB2B,HIST2H3A,CHMP2A,TMEM183A,MED4,SHC2,NVL,CBX2,ZNF770,PON2,UBE2E3,RIF1,VPS45,RASSF1,HMGXB4,FOXP4,TOP2A,SETD8,MOB3A,TOP1,SPTY2D1,KDM6B,FGF2,C9orf5,ALDH1B1,MRPS15,SPECC1L,PABPC4,SNX6,WEE1,NSRP1,PMAIP1,FNIP2,ZNF148,TULP4,SMARCA2,RAB12,WLS,C1orf124,AKAP12,MCL1,USP9X,FBXL3,DDX42,STOX2,NUAK1,ZIC5,AGBL3,IRF2BP2,PNP,TSPYL4,ZNF512B,PLS1,VPS13C,MDH1,ZNF516,SERPINA12,TUBB4B,PKP2,APC,MAVS,SCFD1,NDUFA7,RPLP1,MRPS16,RPS2,TADA3,COG8,PCNP,TK1,GNB2L1,PSMD4,UBE2K,CAMK2B,PROCA1,NUFIP2,C1orf150,FOXRED2,CCAR1,HN1L,KATNAL1,EZR,BRCA1,MED8,USP19,SIN3B,XRCC1,GOLGA4,FOXM1,RBFOX2,SUMO2,ZDHHC6,CASP10,RANBP2,ZNF700,CMTM4,CDT1,PPL,CSNK1A1,ARL14,HSP90AA1,PPM1F,RAI2,SAT2,CGN,SNRNP40,PRKAB2,SMAD5,ID4,IKBIP,YWHAE,STK24,NOL8,SLC4A1AP,WBSCR16,FAM177A1,PSMD8,RPL14,ITGB1,DNAJC27,TXN2,FAM57A,APEH,NDUFA4,HIST1H2BJ,HIST1H2BO,TTC30A,ND5,KCTD12,ARL6IP4,TCP1,GUCY1B3,NAA10,RAB11A,EEF1A1,FBXO42,TTC37,SRGAP2,HELZ,UBE2E2,ST13,HDGF,JOSD1,SLC39A10,RPS26,RALGDS,FNIP1,ZNF324,RANBP10,ECSIT,RNF113A,SLC6A6,PAPD5,NUP62,MZT2B,AADACL3,WNT5A,HNRNPL,SYNJ2BP,HIST1H1C,CUEDC2,SHMT2,MRPL45,ALDH16A1,GINS1,TXNRD1,NASP,POLD3

KEGG pathways enriched for interacted genes

pathway name

pathway description

target genes enrich in pathway

p-value

hsa03010	Ribosome	RPL9,RPL18A,RPL4,RPL5,RPL32,RPS26,RPL27,RPL29,RPLP1,RPS2,RPL14,RPS7,RPS21,RPL36,RPS4X,	2.14E-6
hsa03040	Spliceosome	SRSF6,RBM8A,THOC1,ZMAT2,SNRNP40,CRNKL1,HNRNPC,HNRNPA1,PRPF8,SRSF3,HNRNPU,SRSF2,DDX42,	1.85E-2
hsa03050	Proteasome	PSMD13,PSMD2,PSMD3,PSMD4,PSME1,PSMD8,PSMA2,	6.46E-2
hsa00240	Pyrimidine metabolism	CAD,CTPS,PNP,RRM2,TK1,POLD3,TXNRD1,POLR2D,	5.53E-1
hsa00310	Lysine degradation	SETD8,ECHS1,ALDH1B1,NSD1,SETD7,	7.33E-1

Gene ontology terms enriched for interacted genes

GO terms

GO terms description

target genes enrich in GO term

p-value

GO:0006412	translation	DARS2,EEF1D,EIF2C2,MRPS16,RPL4,RPL18A,EEF2,RPL5,EIF1,RPL32,EIF2A,PABPC4,EEF1A1,MRPL42,RPS2,RPL14,DHPS,COG8,MRPS15,YARS,RPL9,TUFM,EIF3C,RPS26,RPL27,TARSL2,RPL29,RPLP1,EIF3G,EIF4G2,EIF5,RPS21,RPS7,RPL36,IGF2BP3,RPS4X,MRPL45,RPL7L1,	6.76E-11
GO:0006414	translational elongation	EEF1D,RPL4,RPL9,RPL18A,EEF2,RPL5,RPL32,TUFM,RPS26,RPL27,EEF1A1,RPL29,RPLP1,RPS2,RPL14,RPS7,RPS21,RPL36,RPS4X,	4.35E-9
GO:0016071	mRNA metabolic process	SF1,CCAR1,EIF2C2,THOC1,KHSRP,TSEN15,SNRNP40,CNOT6L,RBM10,CRNKL1,CEBPG,HNRNPA1,HNRNPL,XRN2,HNRNPU,RBM28,PPP4R2,SRSF6,SRRM2,ZFP36L2,RBM8A,RBM5,SRPK1,EIF2C1,RBFOX2,SRSF11,TARDBP,HNRNPC,PRPF8,SRSF3,POLR2D,SNRNP35,SMN2,SRSF2,	1.95E-7
GO:0006397	mRNA processing	SF1,CCAR1,EIF2C2,THOC1,KHSRP,TSEN15,SNRNP40,CNOT6L,RBM10,CRNKL1,HNRNPA1,HNRNPL,XRN2,HNRNPU,RBM28,PPP4R2,SRRM2,SRSF6,RBM8A,RBM5,SRPK1,RBFOX2,SRSF11,TARDBP,HNRNPC,PRPF8,SRSF3,SNRNP35,POLR2D,SMN2,SRSF2,	2.65E-7
GO:0044265	cellular macromolecule catabolic process	FBXO42,UBE2Q1,PSMA2,UBXN6,XRN2,FBXL3,SUMO2,RNASEH1,CUEDC2,RLIM,ZFP36L2,USP19,PSMD2,PSMD3,BRCA1,EIF2C1,TULP4,UBE2K,RNF149,RNF167,P2RX7,UBE2E3,CD2AP,CNOT4,PSMD13,MYSM1,ERCC3,PSMD4,PABPC4,PSMD8,PSMD9,RNF2,FOXRED2,RNF6,USP9X,PCNP,DDB1,CAND1,FEM1B,RNF40,RBM8A,FBXL5,MED8,MYLIP,PSME1,DNASE2,RANBP2,HUWE1,G2E3,UBE2E2,RNF111,	5.38E-7

GO:0008380	RNA splicing	SF1,CCAR1,THOC1,KHSRP,SNRNP40,RBM10,CRNKL1,HNRNPA1,HNRNPL,ARL6IP4,HNRNPU,RBM28,PPP4R2,SRRM2,SRSF6,RBM8A,RBM5,SRPK1,RBFOX2,SRSF11,TARDBP,HNRNPC,PRPF8,SRSF3,SNRNP35,POLR2D,SMN2,SRSF2,	7.57E-7
GO:0006396	RNA processing	SF1,CCAR1,EIF2C2,THOC1,RPL5,KHSRP,PABPC4,TSEN15,CNOT6L,SNRNP40,RBM10,RPL14,CRNKL1,HNRNPA1,ARL6IP4,HNRNPL,XRN2,HNRNPU,RBM28,RRP1B,PPP4R2,SRSF6,SRRM2,RBM8A,RBM5,SRPK1,BICD1,DUS3L,ATXN1,RBFOX2,UTP11L,SRSF11,RPS7,TARDBP,HNRNPC,PRPF8,SRSF3,POLR2D,SNRNP35,SMN2,SRSF2,	1.86E-6
GO:0009057	macromolecule catabolic process	FBXO42,UBE2Q1,PSMA2,UBXN6,XRN2,FBXL3,SUMO2,RNASEH1,CUEDC2,RLIM,ZFP36L2,USP19,PSMD2,PSMD3,BRCA1,EIF2C1,TULP4,UBE2K,RNF149,RNF167,P2RX7,UBE2E3,CD2AP,CNOT4,PSMD13,MYSM1,NGLY1,ERCC3,PSMD4,PABPC4,PSMD8,PSMD9,RNF2,FOXRED2,RNF6,USP9X,PCNP,DDB1,CAND1,FEM1B,RNF40,RBM8A,FBXL5,MED8,MYLIP,PSME1,DNASE2,RANBP2,HUWE1,G2E3,UBE2E2,RNF111,	2.01E-6
GO:0043632	modification-dependent macromolecule catabolic process	PSMD13,MYSM1,PSMD4,FBXO42,PSMD8,UBE2Q1,PSMD9,PSMA2,UBXN6,RNF2,FOXRED2,RNF6,USP9X,FBXL3,SUMO2,CUEDC2,PCNP,DDB1,RNF40,FEM1B,CAND1,RLIM,FBXL5,USP19,PSMD2,PSMD3,MED8,BRCA1,TULP4,MYLIP,PSME1,UBE2K,RNF149,RANBP2,HUWE1,RNF167,G2E3,UBE2E3,UBE2E2,RNF111,CD2AP,CNOT4,	2.48E-6
GO:0019941	modification-dependent protein catabolic process	PSMD13,MYSM1,PSMD4,FBXO42,PSMD8,UBE2Q1,PSMD9,PSMA2,UBXN6,RNF2,FOXRED2,RNF6,USP9X,FBXL3,SUMO2,CUEDC2,PCNP,DDB1,RNF40,FEM1B,CAND1,RLIM,FBXL5,USP19,PSMD2,PSMD3,MED8,BRCA1,TULP4,MYLIP,PSME1,UBE2K,RNF149,RANBP2,HUWE1,RNF167,G2E3,UBE2E3,UBE2E2,RNF111,CD2AP,CNOT4,	2.48E-6
GO:0051603	proteolysis involved in cellular protein catabolic process	PSMD13,MYSM1,PSMD4,FBXO42,PSMD8,UBE2Q1,PSMD9,PSMA2,UBXN6,RNF2,FOXRED2,RNF6,USP9X,FBXL3,SUMO2,CUEDC2,PCNP,DDB1,RNF40,FEM1B,CAND1,RLIM,FBXL5,USP19,PSMD2,PSMD3,MED8,BRCA1,TULP4,MYLIP,PSME1,UBE2K,RNF149,RANBP2,HUWE1,RNF167,P2RX7,G2E3,UBE2E3,UBE2E2,RNF111,CD2AP,CNOT4,	3.14E-6
GO:0044257	cellular protein catabolic process	PSMD13,MYSM1,PSMD4,FBXO42,PSMD8,UBE2Q1,PSMD9,PSMA2,UBXN6,RNF2,FOXRED2,RNF6,USP9X,FBXL3,SUMO2,CUEDC2,PCNP,DDB1,RNF40,FEM1B,CAND1,RLIM,FBXL5,USP19,PSMD2,PSMD3,MED8,BRCA1,TULP4,MYLIP,PSME1,UBE2K,RNF149,RANBP2,HUWE1,RNF167,P2RX7,G2E3,UBE2E3,UBE2E2,RNF111,CD2AP,CNOT4,	3.57E-6
GO:0030163	protein catabolic process	PSMD13,MYSM1,PSMD4,FBXO42,PSMD8,UBE2Q1,PSMD9,PSMA2,UBXN6,RNF2,FOXRED2,RNF6,USP9X,FBXL3,SUMO2,CUEDC2,PCNP,DDB1,RNF40,FEM1B,CAND1,RLIM,FBXL5,USP19,PSMD2,PSMD3,MED8,BRCA1,TULP4,MYLIP,PSME1,UBE2K,RNF149,RANBP2,HUWE1,RNF167,P2RX7,G2E3,UBE2E3,UBE2E2,RNF111,CD2AP,CNOT4,	7.63E-6
GO:0051276	chromosome organization	SMARCA2,CBX2,MYSM1,CBX1,H1F0,HIST1H1C,TEX15,HIST1H1E,SUPT16H,MSL3,SETD8,RNF2,TSPYL4,MTA2,BRD1,NASP,KDM6B,HIST1H2BO,HIST1H2BJ,RNF40,APC,TOP2A,SETD7,NCAPD2,MLL2,PTTG1,HUWE1,TADA3,MLL3,NCAPD3,KDM3B,SMARCC2,HIST1H2BK,NSD1,HIST2H3A,CBX3,	1.12E-5
GO:0000278	mitotic cell cycle	PSMD13,TUBB2B,PSMD4,PSMD8,PSMD9,PSMA2,SETD8,RNF2,USP9X,CKAP5,STAG2,PSMD2,CAMK2B,BUB1,PSMD3,ACVR1,APC,KIF11,PSME1,WEE1,RAN,NCAPD2,PTTG1,ITGB1,TARDBP,ID4,TUBB,NCAPD3,CD2AP,PAPD5,	1.38E-5
GO:0006325	chromatin organization	SMARCA2,CBX2,MYSM1,CBX1,H1F0,HIST1H1C,HIST1H1E,SUPT16H,MSL3,SETD8,RNF2,TSPYL4,MTA2,BRD1,NASP,KDM6B,HIST1H2BO,HIST1H2BJ,RNF40,SETD7,MLL2,HUWE1,TADA3,MLL3,KDM3B,SMARCC2,HIST1H2BK,NSD1,HIST2H3A,CBX3,	2.08E-5
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	SRSF6,SF1,RBM8A,CCAR1,RBM5,SNRNP40,SRSF11,CRNKL1,HNRNPC,HNRNPA1,HNRNPL,PRPF8,HNRNPU,SRSF3,POLR2D,SMN2,SRSF2,	4.39E-5
GO:0000375	RNA splicing, via transesterification reactions	SRSF6,SF1,RBM8A,CCAR1,RBM5,SNRNP40,SRSF11,CRNKL1,HNRNPC,HNRNPA1,HNRNPL,PRPF8,HNRNPU,SRSF3,POLR2D,SMN2,SRSF2,	4.39E-5
GO:0000398	nuclear mRNA splicing, via spliceosome	SRSF6,SF1,RBM8A,CCAR1,RBM5,SNRNP40,SRSF11,CRNKL1,HNRNPC,HNRNPA1,HNRNPL,PRPF8,HNRNPU,SRSF3,POLR2D,SMN2,SRSF2,	4.39E-5
GO:0006333	chromatin assembly or disassembly	CBX2,CBX1,H1F0,HIST1H1C,HIST1H1E,SUPT16H,MSL3,TSPYL4,MTA2,HIST1H2BK,HIST1H2BO,SMARCC2,HIST1H2BJ,HIST2H3A,CBX3,	7.37E-5
GO:0034621	cellular macromolecular complex subunit organization	SF1,TUBB2B,EIF2A,H1F0,HIST1H1C,TCP1,TSR1,HIST1H1E,SUPT16H,CRNKL1,TUBB4B,AHCTF1,TSPYL4,HSP90AA1,XRN2,NASP,HIST1H2BO,XPO7,HIST1H2BJ,SRSF6,RBM5,TNPO2,TUBB,SMAD4,HIST1H2BK,SMN2,HIST2H3A,	1.31E-4
GO:0007049	cell cycle	SF1,CCAR1,PSMD13,ILF3,TUBB2B,PSMD4,RIF1,PSMD8,PSMD9,TEX15,PSMA2,SETD8,RNF2,USP9X,NASP,PTP4A1,CKAP5,PCNP,SEPT9,STAG2,CDT1,PSMD2,PSMD3,BUB1,CAMK2B,BRCA1,ACVR1,KIF11,APC,PSME1,WEE1,FOXM1,SEPT11,RASSF1,NCAPD2,RAN,PTTG1,EIF4G2,ITGB1,TARDBP,ID4,TUBB,CD2AP,NCAPD3,SPECC1L,PAPD5,	1.47E-4
GO:0034622	cellular macromolecular complex assembly	SRSF6,SF1,RBM5,TUBB2B,EIF2A,H1F0,HIST1H1C,TCP1,TNPO2,TSR1,HIST1H1E,CRNKL1,TUBB4B,AHCTF1,TSPYL4,HSP90AA1,TUBB,SMAD4,HIST1H2BK,HIST1H2BO,XPO7,SMN2,HIST1H2BJ,HIST2H3A,	3.51E-4
GO:0006403	RNA localization	NUP62,RBM8A,HNRNPA1,THOC5,THOC1,KHSRP,BICD1,NUPL2,XPO7,CKAP5,RAN,RANBP2,	4.37E-4
GO:0001702	gastrulation with mouth forming second	FRS2,RNF2,ACVR2A,ACVR1,SMAD4,NSD1,	4.95E-4
GO:0022402	cell cycle process	SF1,PSMD13,ILF3,TUBB2B,PSMD4,PSMD8,PSMD9,TEX15,PSMA2,SETD8,USP9X,CKAP5,STAG2,PSMD2,CAMK2B,BUB1,PSMD3,BRCA1,ACVR1,KIF11,APC,PSME1,WEE1,RASSF1,RAN,NCAPD2,PTTG1,EIF4G2,ITGB1,TARDBP,ID4,TUBB,CD2AP,NCAPD3,PAPD5,	5.15E-4
GO:0010498	proteasomal protein catabolic process	PSMD13,USP19,PSMD2,PSMD3,FOXRED2,PSMD4,CD2AP,PSME1,PSMD8,PCNP,PSMD9,PSMA2,	5.19E-4
GO:0043161	proteasomal ubiquitin-dependent protein catabolic process	PSMD13,USP19,PSMD2,PSMD3,FOXRED2,PSMD4,CD2AP,PSME1,PSMD8,PCNP,PSMD9,PSMA2,	5.19E-4
GO:0043933	macromolecular complex subunit organization	SF1,LLGL1,ATL3,TUBB2B,H1F0,EIF2A,HIST1H1C,RRM2,ERCC3,TCP1,TSR1,HIST1H1E,SUPT16H,MDN1,TUBB4B,CRNKL1,AHCTF1,HSP90AA1,TSPYL4,NASP,XRN2,HIST1H2BO,XPO7,HIST1H2BJ,SEPT9,SRSF6,RBM5,SOAT1,APC,SEPT11,TNPO2,ATL2,P2RX7,MED4,TUBB,CD2AP,SMAD4,POLR2D,HIST1H2BK,SMN2,HIST2H3A,	6.16E-4
GO:0070647	protein modification by small protein conjugation or removal	FBXL5,MYSM1,BRCA1,MYLIP,HUWE1,RNF167,G2E3,RNF2,USP9X,FBXL3,SUMO2,PCNP,DDB1,CAND1,RNF40,	8.19E-4
GO:0022904	respiratory electron transport chain	ATP6,CYTB,NDUFA4,NDUFA2,NDUFB6,COX1,NDUFA7,ND5,SLC25A13,COX3,	1.13E-2
GO:0015931	nucleobase, nucleoside, nucleotide and nucleic acid transport	NUP62,RBM8A,HNRNPA1,THOC5,THOC1,KHSRP,NUPL2,XPO7,VDAC3,CKAP5,RAN,RANBP2,	1.22E-2
GO:0065003	macromolecular complex assembly	SF1,LLGL1,ATL3,TUBB2B,EIF2A,H1F0,HIST1H1C,RRM2,ERCC3,TCP1,TSR1,HIST1H1E,MDN1,CRNKL1,TUBB4B,AHCTF1,HSP90AA1,TSPYL4,HIST1H2BO,XPO7,HIST1H2BJ,SEPT9,SRSF6,RBM5,SOAT1,APC,SEPT11,TNPO2,ATL2,P2RX7,MED4,TUBB,CD2AP,SMAD4,POLR2D,HIST1H2BK,SMN2,HIST2H3A,	1.23E-2
GO:0051236	establishment of RNA localization	NUP62,RBM8A,HNRNPA1,THOC5,THOC1,KHSRP,NUPL2,XPO7,CKAP5,RAN,RANBP2,	1.30E-2
GO:0050657	nucleic acid transport	NUP62,RBM8A,HNRNPA1,THOC5,THOC1,KHSRP,NUPL2,XPO7,CKAP5,RAN,RANBP2,	1.30E-2
GO:0050658	RNA transport	NUP62,RBM8A,HNRNPA1,THOC5,THOC1,KHSRP,NUPL2,XPO7,CKAP5,RAN,RANBP2,	1.30E-2
GO:0032446	protein modification by small protein conjugation	FBXL5,BRCA1,MYLIP,HUWE1,RNF167,G2E3,RNF2,FBXL3,SUMO2,PCNP,DDB1,CAND1,RNF40,	1.36E-2
GO:0006323	DNA packaging	NAA10,TSPYL4,H1F0,HIST1H1C,NCAPD3,HIST1H2BO,HIST1H2BK,TOP2A,NCAPD2,HIST1H2BJ,HIST2H3A,HIST1H1E,	1.63E-2
GO:0016567	protein ubiquitination	HUWE1,RNF167,RNF2,G2E3,FBXL5,BRCA1,MYLIP,FBXL3,PCNP,DDB1,RNF40,CAND1,	1.86E-2
GO:0032268	regulation of cellular protein metabolic process	PSMD13,KIAA1804,EIF2C2,EIF1,EIF2A,PSMD4,PSMD8,PSMD9,DLC1,PSMA2,FGF2,PUM1,FEM1B,RBM8A,PSMD2,PSMD3,BRCA1,ACVR2A,EIF2C1,PSME1,HSP90AB1,EIF4G2,P2RX7,EIF5,IGF2BP3,SMAD4,PPP1R15B,YWHAE,RPS4X,	2.07E-2
GO:0010605	negative regulation of macromolecule metabolic process	SMARCA2,PSMD13,ILF3,EIF2C2,CBX2,ZNF148,PSMD4,PSMD8,PSMD9,FOXK1,PSMA2,SIN3B,SETD8,RNF2,SPEN,FGF2,MTA2,SNX6,KDM6B,RLIM,CDT1,PSMD2,PSMD3,BRCA1,EIF2C1,LRRFIP1,ATXN1,RPS26,RBFOX2,PSME1,HSP90AB1,IGF2BP3,FOXP4,ID4,SMAD4,ZC3H8,SMARCC2,YWHAE,NSD1,CBX3,	2.09E-2
GO:0042773	ATP synthesis coupled electron transport	ATP6,CYTB,NDUFA4,NDUFA2,NDUFB6,COX1,NDUFA7,ND5,COX3,	2.29E-2
GO:0042775	mitochondrial ATP synthesis coupled electron transport	ATP6,CYTB,NDUFA4,NDUFA2,NDUFB6,COX1,NDUFA7,ND5,COX3,	2.29E-2
GO:0000280	nuclear division	BUB1,TUBB2B,APC,KIF11,WEE1,RAN,NCAPD2,PTTG1,SETD8,TARDBP,TUBB,USP9X,NCAPD3,CD2AP,CKAP5,PAPD5,STAG2,	2.54E-2
GO:0007067	mitosis	BUB1,TUBB2B,APC,KIF11,WEE1,RAN,NCAPD2,PTTG1,SETD8,TARDBP,TUBB,USP9X,NCAPD3,CD2AP,CKAP5,PAPD5,STAG2,	2.54E-2
GO:0000087	M phase of mitotic cell cycle	BUB1,TUBB2B,APC,KIF11,WEE1,RAN,NCAPD2,PTTG1,SETD8,TARDBP,TUBB,USP9X,NCAPD3,CD2AP,CKAP5,PAPD5,STAG2,	3.04E-2
GO:0034728	nucleosome organization	SUPT16H,TSPYL4,H1F0,NASP,HIST1H1C,HIST1H2BO,HIST1H2BK,HIST1H2BJ,HIST2H3A,HIST1H1E,	3.47E-2
GO:0048285	organelle fission	BUB1,TUBB2B,APC,KIF11,WEE1,RAN,NCAPD2,PTTG1,SETD8,TARDBP,TUBB,USP9X,NCAPD3,CD2AP,CKAP5,PAPD5,STAG2,	3.78E-2
GO:0051438	regulation of ubiquitin-protein ligase activity	PSMD13,PSMD2,PSMD3,PSMD4,PSME1,PSMD8,PSMD9,FEM1B,PSMA2,	4.02E-2
GO:0051301	cell division	BUB1,TOP1,KIT,APC,KIF11,WEE1,SEPT11,RAN,NCAPD2,PTTG1,SETD8,AHCTF1,USP9X,NCAPD3,CD2AP,SPECC1L,CKAP5,PAPD5,SEPT9,STAG2,	4.15E-2
GO:0016568	chromatin modification	SMARCA2,MYSM1,CBX2,SETD7,MLL2,HUWE1,SETD8,MSL3,RNF2,TADA3,MLL3,BRD1,NASP,KDM6B,KDM3B,SMARCC2,NSD1,CBX3,RNF40,	4.23E-2
GO:0022900	electron transport chain	ATP6,CYTB,TXN2,NDUFA4,NDUFA2,NDUFB6,COX1,TXNRD1,NDUFA7,ND5,SLC25A13,COX3,	4.32E-2
GO:0045333	cellular respiration	ATP6,CYTB,NDUFA4,NDUFA2,NDUFB6,MDH1,COX1,NDUFA7,ND5,SLC25A13,COX3,	4.60E-2
GO:0051340	regulation of ligase activity	PSMD13,PSMD2,PSMD3,PSMD4,PSME1,PSMD8,PSMD9,FEM1B,PSMA2,	5.07E-2
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	PSMD13,PSMD2,PSMD3,PSMD4,PSME1,PSMD8,PSMD9,PSMA2,	5.34E-2
GO:0051436	negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle	PSMD13,PSMD2,PSMD3,PSMD4,PSME1,PSMD8,PSMD9,PSMA2,	5.34E-2
GO:0031396	regulation of protein ubiquitination	PSMD13,PSMD2,PSMD3,BRCA1,PSMD4,PSME1,PSMD8,PSMD9,FEM1B,PSMA2,	5.62E-2
GO:0051444	negative regulation of ubiquitin-protein ligase activity	PSMD13,PSMD2,PSMD3,PSMD4,PSME1,PSMD8,PSMD9,PSMA2,	6.31E-2
GO:0051352	negative regulation of ligase activity	PSMD13,PSMD2,PSMD3,PSMD4,PSME1,PSMD8,PSMD9,PSMA2,	6.31E-2
GO:0031398	positive regulation of protein ubiquitination	PSMD13,PSMD2,PSMD3,BRCA1,PSMD4,PSME1,PSMD8,PSMD9,PSMA2,	6.31E-2
GO:0010604	positive regulation of macromolecule metabolic process	NUP62,SMARCA2,PSMD13,ILF3,SCRIB,MYSM1,ELK1,ZNF148,PSMD4,ERCC3,PSMD8,DLC1,PSMD9,FOXK1,PSMA2,CEBPG,MTA2,FGF2,BCL11B,RNF6,SMAD5,CAND1,SOAT1,PSMD2,PSMD3,FOXO1,BRCA1,ACVR2A,ACVR1,ATXN1,APC,KIT,PSME1,SP1,RAN,PPARGC1B,P2RX7,SMAD4,YWHAH,SMARCC2,RPS4X,NSD1,CNBP,	6.35E-2
GO:0006511	ubiquitin-dependent protein catabolic process	PSMD13,USP19,PSMD2,PSMD3,PSMD4,PSME1,UBE2K,PSMD8,PSMD9,PSMA2,FOXRED2,RNF6,USP9X,CD2AP,PCNP,DDB1,RNF40,	6.40E-2
GO:0051437	positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle	PSMD13,PSMD2,PSMD3,PSMD4,PSME1,PSMD8,PSMD9,PSMA2,	6.84E-2
GO:0051028	mRNA transport	NUP62,RBM8A,HNRNPA1,THOC5,THOC1,KHSRP,NUPL2,XPO7,RANBP2,	7.78E-2
GO:0051443	positive regulation of ubiquitin-protein ligase activity	PSMD13,PSMD2,PSMD3,PSMD4,PSME1,PSMD8,PSMD9,PSMA2,	8.00E-2
GO:0007369	gastrulation	FRS2,RNF2,ACVR2A,ECSIT,ACVR1,SMAD4,TXNRD1,NSD1,	8.00E-2
GO:0006508	proteolysis	CASP10,FBXO42,UBE2Q1,PSMA2,UBXN6,AMZ1,FBXL3,SUMO2,CUEDC2,RLIM,USP19,PSMD2,PSMD3,BRCA1,TULP4,UBE2K,RNF149,RNF167,P2RX7,UBE2E3,AGBL3,RNPEP,CD2AP,CNOT4,PSMD13,MYSM1,PSMD4,PSMD8,PSMD9,RNF2,FOXRED2,RNF6,USP9X,PCNP,DDB1,CAND1,FEM1B,RNF40,FBXL5,PEG10,APEH,MED8,CD46,MYLIP,PSME1,RANBP2,HUWE1,G2E3,UBE2E2,RNF111,	8.50E-2
GO:0051439	regulation of ubiquitin-protein ligase activity during mitotic cell cycle	PSMD13,PSMD2,PSMD3,PSMD4,PSME1,PSMD8,PSMD9,PSMA2,	8.63E-2
GO:0031344	regulation of cell projection organization	ULK1,DBN1,RALA,NRP1,RNF6,PLXNB2,YWHAH,KIT,APC,	8.88E-2
GO:0031401	positive regulation of protein modification process	PSMD13,PSMD2,PSMD3,ACVR2A,BRCA1,PSMD4,PSME1,PSMD8,PSMD9,DLC1,PSMA2,P2RX7,FGF2,SMAD4,	8.95E-2
GO:0051351	positive regulation of ligase activity	PSMD13,PSMD2,PSMD3,PSMD4,PSME1,PSMD8,PSMD9,PSMA2,	1.00E-1
GO:0022403	cell cycle phase	PSMD13,ILF3,CAMK2B,BUB1,TUBB2B,ACVR1,KIF11,APC,WEE1,NCAPD2,RAN,TEX15,PTTG1,SETD8,ITGB1,TARDBP,ID4,TUBB,USP9X,NCAPD3,CD2AP,CKAP5,PAPD5,STAG2,	1.00E-1

KEGG pathways and Gene Ontology terms enriched for the interacted genes of ncRNA from RAID and miRTarBase.

disease name	related genes	p-value