ncRNADetailInformation

Detail Information
Functional analysis

miRNA name

pre-miRNA

family

pre-miRNA Sequence

mature-miRNA

mature sequence

pre-miRNA description

miR-183

MI0000273	MIPF0000066	CCGCAGAGUGUGACUCCUGUUCUGUGUAUGGCACUGGUAGAAUUCACUGUGAACAGUCUCAGUCAGUGAAUUACCGAAGGGCCAUAAACAGAGCAGAGACAGAUCCACGA	MIMAT0000261 hsa-miR-183-5p	UAUGGCACUGGUAGAAUUCACU	This human miRNA was predicted by computational methods using conservationwith mouse and Fugu rubripes sequences . Expression of the excised miRhas been validated in zebrafish, and the 5' end mapped by PCR. Expressionwas later confirmed in human [2,3]. The mature sequence shown hererepresents the most commonly cloned form from large-scale cloning studies.
MI0000273	MIPF0000066	CCGCAGAGUGUGACUCCUGUUCUGUGUAUGGCACUGGUAGAAUUCACUGUGAACAGUCUCAGUCAGUGAAUUACCGAAGGGCCAUAAACAGAGCAGAGACAGAUCCACGA	MIMAT0004560 hsa-miR-183-3p	GUGAAUUACCGAAGGGCCAUAA	This human miRNA was predicted by computational methods using conservationwith mouse and Fugu rubripes sequences . Expression of the excised miRhas been validated in zebrafish, and the 5' end mapped by PCR. Expressionwas later confirmed in human [2,3]. The mature sequence shown hererepresents the most commonly cloned form from large-scale cloning studies.
MI0000098	MIPF0000072	UGGCCGAUUUUGGCACUAGCACAUUUUUGCUUGUGUCUCUCCGCUCUGAGCAAUCAUGUGCAGUGCCAAUAUGGGAAA	MIMAT0000095 hsa-miR-96-5p	UUUGGCACUAGCACAUUUUUGCU	This sequence is localised to chromosome 7 and was named mir-96-7 inreference . The mature sequence shown here represents the mostcommonly cloned form from large-scale cloning studies .
MI0000098	MIPF0000072	UGGCCGAUUUUGGCACUAGCACAUUUUUGCUUGUGUCUCUCCGCUCUGAGCAAUCAUGUGCAGUGCCAAUAUGGGAAA	MIMAT0004510 hsa-miR-96-3p	AAUCAUGUGCAGUGCCAAUAUG	This sequence is localised to chromosome 7 and was named mir-96-7 inreference . The mature sequence shown here represents the mostcommonly cloned form from large-scale cloning studies .
MI0000098	MIPF0000072	UGGCCGAUUUUGGCACUAGCACAUUUUUGCUUGUGUCUCUCCGCUCUGAGCAAUCAUGUGCAGUGCCAAUAUGGGAAA	MIMAT0000095 hsa-miR-96-5p	UUUGGCACUAGCACAUUUUUGCU	This sequence is localised to chromosome 7 and was named mir-96-7 inreference . The mature sequence shown here represents the mostcommonly cloned form from large-scale cloning studies .
MI0000098	MIPF0000072	UGGCCGAUUUUGGCACUAGCACAUUUUUGCUUGUGUCUCUCCGCUCUGAGCAAUCAUGUGCAGUGCCAAUAUGGGAAA	MIMAT0004510 hsa-miR-96-3p	AAUCAUGUGCAGUGCCAAUAUG	This sequence is localised to chromosome 7 and was named mir-96-7 inreference . The mature sequence shown here represents the mostcommonly cloned form from large-scale cloning studies .
MI0000098	MIPF0000072	UGGCCGAUUUUGGCACUAGCACAUUUUUGCUUGUGUCUCUCCGCUCUGAGCAAUCAUGUGCAGUGCCAAUAUGGGAAA	MIMAT0000095 hsa-miR-96-5p	UUUGGCACUAGCACAUUUUUGCU	This sequence is localised to chromosome 7 and was named mir-96-7 inreference . The mature sequence shown here represents the mostcommonly cloned form from large-scale cloning studies .
MI0000098	MIPF0000072	UGGCCGAUUUUGGCACUAGCACAUUUUUGCUUGUGUCUCUCCGCUCUGAGCAAUCAUGUGCAGUGCCAAUAUGGGAAA	MIMAT0004510 hsa-miR-96-3p	AAUCAUGUGCAGUGCCAAUAUG	This sequence is localised to chromosome 7 and was named mir-96-7 inreference . The mature sequence shown here represents the mostcommonly cloned form from large-scale cloning studies .
MI0000273	MIPF0000066	CCGCAGAGUGUGACUCCUGUUCUGUGUAUGGCACUGGUAGAAUUCACUGUGAACAGUCUCAGUCAGUGAAUUACCGAAGGGCCAUAAACAGAGCAGAGACAGAUCCACGA	MIMAT0000261 hsa-miR-183-5p	UAUGGCACUGGUAGAAUUCACU	This human miRNA was predicted by computational methods using conservationwith mouse and Fugu rubripes sequences . Expression of the excised miRhas been validated in zebrafish, and the 5' end mapped by PCR. Expressionwas later confirmed in human [2,3]. The mature sequence shown hererepresents the most commonly cloned form from large-scale cloning studies.
MI0000273	MIPF0000066	CCGCAGAGUGUGACUCCUGUUCUGUGUAUGGCACUGGUAGAAUUCACUGUGAACAGUCUCAGUCAGUGAAUUACCGAAGGGCCAUAAACAGAGCAGAGACAGAUCCACGA	MIMAT0004560 hsa-miR-183-3p	GUGAAUUACCGAAGGGCCAUAA	This human miRNA was predicted by computational methods using conservationwith mouse and Fugu rubripes sequences . Expression of the excised miRhas been validated in zebrafish, and the 5' end mapped by PCR. Expressionwas later confirmed in human [2,3]. The mature sequence shown hererepresents the most commonly cloned form from large-scale cloning studies.
MI0000273	MIPF0000066	CCGCAGAGUGUGACUCCUGUUCUGUGUAUGGCACUGGUAGAAUUCACUGUGAACAGUCUCAGUCAGUGAAUUACCGAAGGGCCAUAAACAGAGCAGAGACAGAUCCACGA	MIMAT0000261 hsa-miR-183-5p	UAUGGCACUGGUAGAAUUCACU	This human miRNA was predicted by computational methods using conservationwith mouse and Fugu rubripes sequences . Expression of the excised miRhas been validated in zebrafish, and the 5' end mapped by PCR. Expressionwas later confirmed in human [2,3]. The mature sequence shown hererepresents the most commonly cloned form from large-scale cloning studies.
MI0000273	MIPF0000066	CCGCAGAGUGUGACUCCUGUUCUGUGUAUGGCACUGGUAGAAUUCACUGUGAACAGUCUCAGUCAGUGAAUUACCGAAGGGCCAUAAACAGAGCAGAGACAGAUCCACGA	MIMAT0004560 hsa-miR-183-3p	GUGAAUUACCGAAGGGCCAUAA	This human miRNA was predicted by computational methods using conservationwith mouse and Fugu rubripes sequences . Expression of the excised miRhas been validated in zebrafish, and the 5' end mapped by PCR. Expressionwas later confirmed in human [2,3]. The mature sequence shown hererepresents the most commonly cloned form from large-scale cloning studies.
MI0000273	MIPF0000066	CCGCAGAGUGUGACUCCUGUUCUGUGUAUGGCACUGGUAGAAUUCACUGUGAACAGUCUCAGUCAGUGAAUUACCGAAGGGCCAUAAACAGAGCAGAGACAGAUCCACGA	MIMAT0000261 hsa-miR-183-5p	UAUGGCACUGGUAGAAUUCACU	This human miRNA was predicted by computational methods using conservationwith mouse and Fugu rubripes sequences . Expression of the excised miRhas been validated in zebrafish, and the 5' end mapped by PCR. Expressionwas later confirmed in human [2,3]. The mature sequence shown hererepresents the most commonly cloned form from large-scale cloning studies.
MI0000273	MIPF0000066	CCGCAGAGUGUGACUCCUGUUCUGUGUAUGGCACUGGUAGAAUUCACUGUGAACAGUCUCAGUCAGUGAAUUACCGAAGGGCCAUAAACAGAGCAGAGACAGAUCCACGA	MIMAT0004560 hsa-miR-183-3p	GUGAAUUACCGAAGGGCCAUAA	This human miRNA was predicted by computational methods using conservationwith mouse and Fugu rubripes sequences . Expression of the excised miRhas been validated in zebrafish, and the 5' end mapped by PCR. Expressionwas later confirmed in human [2,3]. The mature sequence shown hererepresents the most commonly cloned form from large-scale cloning studies.

link to database

TargetScanS 6.2 | MicroCosm | microRNA.org | miRNAMap 2.0

Interacted genes from RAID,miRTarBase

ITGA8,ABCC10,SENP1,BRPF1,KLHL23,SERTAD4,GNL3,AKAP12,ELAC2,RPAP2,RCN2,PSMD13,PDCD4,WNK1,RBM34
more » ITGA8,ABCC10,SENP1,BRPF1,KLHL23,SERTAD4,GNL3,AKAP12,ELAC2,RPAP2,RCN2,PSMD13,PDCD4,WNK1,RBM34,PHF14,AAMP,FOXN2,DGAT1,MYO10,SHISA2,TRIM37,ABCF1,CPEB1,RDH11,TSR1,CEPT1,LAPTM4B,CNOT6,C18orf25,STIP1,UBP1,FAM108C1,CCND1,STK40,GCC1,FEN1,PTPN9,KIF2A,ARHGAP21,HIPK2,DMWD,TNRC6B,SLC5A3,ITPKB,MKL1,NEO1,HNRNPM,FGF9,ZC3H18,NUB1,USP8,HYOU1,GNB2L1,PLOD2,PLEKHM1,TRO,BTRC,CYB5D2,CSNK2A1,NUFIP2,GLUL,FAM188A,MCM4,SRSF2,P4HB,ARHGEF5,PPRC1,HARS,EZR,RAB5B,INSIG1,FOXO1,ARFGAP2,RPL23,USP19,IGF1R,TUT1,TIMELESS,PREB,PDE8A,REV3L,THOC2,PTP4A2,DOCK1,CTDSPL,IZUMO2,FAM110B,COMMD8,FAM175B,HCFC1,ZC3H4,POLH,AUH,DAP,TTF2,HSP90AA1,TRIT1,BTAF1,CCT3,ITGA5,CAPNS1,API5,RPLP0,PDCD6,FNTB,OTUD4,C22orf13,FOXK2,MYCBP2,CCNB1,RNF41,SRSF10,DTYMK,USP22,ITGB1,EGR1,NOTCH2,PSEN1,GAS1,MTUS1,SLC31A1,OPN3,MSH2,TNRC18,SERTAD2,CR1,PPP3R1,GSPT1,ZBTB34,FAM104A,IDH2,NIPBL,C14orf1,GSR,ASNS,TXNIP,C5orf24,C15orf39,ERC1,TRIM28,HINT1,C10orf2,KIF5C,RTN4,HLA-A,UBXN7,PTPN11,WDR53,LYPLA1,NHSL2,TPRG1L,KAT2A,UQCRC1,UCHL3,KIAA0430,LARP1,ST13,UBE2Z,STK33,SNRPD3,MAP1LC3B,EIF4A3,LARS,GATA6,TRAF4,MTF2,BCL11B,RALGDS,KNTC1,WASH3P,ZFAT,SLC2A3,MASTL,FKBPL,MYBBP1A,SMEK1,TMEM108,CS,CLIC1,HNRNPL,BAG4,SFSWAP,GLO1,ZFHX4,ARHGDIA,KDELC2,KLHL24,SH3D19,RIF1,FAT2,RC3H2,C9orf5,ARHGAP32,LENG8,PEAK1,NAA30,TUBB1,HSPA1B

KEGG pathways enriched for interacted genes

pathway name

pathway description

target genes enrich in pathway

p-value

hsa03040	Spliceosome	HSPA1B,HNRNPM,EIF4A3,SNRPD3,THOC2,SRSF2,SRSF10,	6.40E-2
hsa04144	Endocytosis	IGF1R,HSPA1B,ARFGAP2,USP8,RAB5B,RNF41,HLA-A,	3.54E-1
hsa04114	Oocyte meiosis	IGF1R,CPEB1,BTRC,CCNB1,PPP3R1,	5.87E-1
hsa05200	Pathways in cancer	CCND1,IGF1R,ITGB1,TRAF4,HSP90AA1,FOXO1,FGF9,MSH2,RALGDS,	6.94E-1
hsa05020	Prion diseases	HSPA1B,STIP1,EGR1,	7.90E-1

Gene ontology terms enriched for interacted genes

GO terms

GO terms description

target genes enrich in GO term

p-value

GO:0043066	negative regulation of apoptosis	HSPA1B,BAG4,FOXO1,NOTCH2,MSH2,PSEN1,MKL1,GLO1,IGF1R,HIPK2,ASNS,BCL11B,ARHGDIA,API5,	1.28E-4
GO:0043069	negative regulation of programmed cell death	HSPA1B,BAG4,FOXO1,NOTCH2,MSH2,PSEN1,MKL1,GLO1,IGF1R,HIPK2,ASNS,BCL11B,ARHGDIA,API5,	1.47E-4
GO:0060548	negative regulation of cell death	HSPA1B,BAG4,FOXO1,NOTCH2,MSH2,PSEN1,MKL1,GLO1,IGF1R,HIPK2,ASNS,BCL11B,ARHGDIA,API5,	1.51E-4
GO:0042981	regulation of apoptosis	GAS1,HSPA1B,BAG4,RTN4,TRAF4,NOTCH2,FOXO1,GSPT1,MSH2,PSEN1,MKL1,GLO1,PPP3R1,IGF1R,PDCD6,TXNIP,HIPK2,ASNS,BCL11B,ARHGDIA,API5,DAP,	1.59E-4
GO:0043067	regulation of programmed cell death	GAS1,HSPA1B,BAG4,RTN4,TRAF4,NOTCH2,FOXO1,GSPT1,MSH2,PSEN1,MKL1,GLO1,PPP3R1,IGF1R,PDCD6,TXNIP,HIPK2,ASNS,BCL11B,ARHGDIA,API5,DAP,	1.82E-4

GO:0010941	regulation of cell death	GAS1,HSPA1B,BAG4,RTN4,TRAF4,NOTCH2,FOXO1,GSPT1,MSH2,PSEN1,MKL1,GLO1,PPP3R1,IGF1R,PDCD6,TXNIP,HIPK2,ASNS,BCL11B,ARHGDIA,API5,DAP,	1.92E-4
GO:0051726	regulation of cell cycle	GAS1,CCND1,PTPN11,MSH2,PDCD4,KNTC1,ITGB1,ASNS,TIMELESS,USP22,CCNB1,MYCBP2,HCFC1,	2.63E-4
GO:0006916	anti-apoptosis	IGF1R,BAG4,HSPA1B,NOTCH2,FOXO1,ARHGDIA,PSEN1,API5,MKL1,GLO1,	4.15E-4
GO:0016071	mRNA metabolic process	HSPA1B,SFSWAP,HNRNPM,SNRPD3,GSPT1,TTF2,EIF4A3,CPEB1,HNRNPL,THOC2,AUH,SRSF2,SRSF10,	7.14E-4
GO:0012501	programmed cell death	GAS1,BAG4,RTN4,TRAF4,GSPT1,UBE2Z,MSH2,PSEN1,GATA6,DOCK1,PDCD4,PPP3R1,PDCD6,HIPK2,API5,FAM188A,DAP,	9.86E-4
GO:0007049	cell cycle	GAS1,CCND1,PSMD13,TUBB1,NOTCH2,DMWD,GSPT1,MSH2,BTRC,RIF1,KNTC1,ITGB1,DTYMK,TXNIP,NIPBL,TIMELESS,USP22,CCNB1,HCFC1,	1.88E-2
GO:0008219	cell death	GAS1,C10orf2,BAG4,RTN4,TRAF4,UBE2Z,GSPT1,MSH2,PSEN1,GATA6,DOCK1,PDCD4,PPP3R1,PDCD6,HIPK2,API5,FAM188A,DAP,	2.06E-2
GO:0016265	death	GAS1,C10orf2,BAG4,RTN4,TRAF4,UBE2Z,GSPT1,MSH2,PSEN1,GATA6,DOCK1,PDCD4,PPP3R1,PDCD6,HIPK2,API5,FAM188A,DAP,	2.22E-2
GO:0044265	cellular macromolecule catabolic process	HSPA1B,MAP1LC3B,PSMD13,USP19,GSPT1,UBE2Z,PSEN1,SENP1,BTRC,RNF41,UCHL3,EIF4A3,FEN1,USP8,USP22,CCNB1,AUH,MYCBP2,	2.25E-2
GO:0006915	apoptosis	BAG4,RTN4,TRAF4,GSPT1,UBE2Z,MSH2,PSEN1,GATA6,DOCK1,PDCD4,PPP3R1,PDCD6,HIPK2,API5,FAM188A,DAP,	2.30E-2
GO:0009057	macromolecule catabolic process	HSPA1B,MAP1LC3B,PSMD13,USP19,GSPT1,UBE2Z,PSEN1,SENP1,BTRC,RNF41,UCHL3,EIF4A3,FEN1,USP8,USP22,CCNB1,AUH,MYCBP2,	4.80E-2
GO:0006401	RNA catabolic process	HSPA1B,EIF4A3,FEN1,GSPT1,AUH,	5.42E-2
GO:0006397	mRNA processing	TTF2,HNRNPM,SFSWAP,EIF4A3,CPEB1,SNRPD3,HNRNPL,THOC2,SRSF2,SRSF10,	8.41E-2
GO:0022402	cell cycle process	GAS1,CCND1,TUBB1,PSMD13,NOTCH2,DMWD,GSPT1,MSH2,BTRC,KNTC1,ITGB1,NIPBL,TIMELESS,CCNB1,	8.60E-2

KEGG pathways and Gene Ontology terms enriched for the interacted genes of ncRNA from RAID and miRTarBase.

disease name	related genes	p-value