ncRNADetailInformation

Detail Information
Functional analysis

miRNA name

pre-miRNA

family

pre-miRNA Sequence

mature-miRNA

mature sequence

pre-miRNA description

miR-15

MI0000069	MIPF0000006	CCUUGGAGUAAAGUAGCAGCACAUAAUGGUUUGUGGAUUUUGAAAAGGUGCAGGCCAUAUUGUGCUGCCUCAAAAAUACAAGG	MIMAT0000068 hsa-miR-15a-5p	UAGCAGCACAUAAUGGUUUGUG	Reference named this sequence miR-15. This is renamed miR-15a here toavoid confusion with miR-15b (MIR:MI0000438) identified later by others.This gene and miR-16 are clustered within 0.5 kb at 13q14. This regionhas been shown to be deleted in more than half of B cell chroniclymphocytic leukemias (CLL). Both miR-15a and miR-16 are deleted ordown-regulated in more than two thirds of CLL cases .
MI0000069	MIPF0000006	CCUUGGAGUAAAGUAGCAGCACAUAAUGGUUUGUGGAUUUUGAAAAGGUGCAGGCCAUAUUGUGCUGCCUCAAAAAUACAAGG	MIMAT0004488 hsa-miR-15a-3p	CAGGCCAUAUUGUGCUGCCUCA	Reference named this sequence miR-15. This is renamed miR-15a here toavoid confusion with miR-15b (MIR:MI0000438) identified later by others.This gene and miR-16 are clustered within 0.5 kb at 13q14. This regionhas been shown to be deleted in more than half of B cell chroniclymphocytic leukemias (CLL). Both miR-15a and miR-16 are deleted ordown-regulated in more than two thirds of CLL cases .
MI0000438	MIPF0000006	UUGAGGCCUUAAAGUACUGUAGCAGCACAUCAUGGUUUACAUGCUACAGUCAAGAUGCGAAUCAUUAUUUGCUGCUCUAGAAAUUUAAGGAAAUUCAU	MIMAT0000417 hsa-miR-15b-5p	UAGCAGCACAUCAUGGUUUACA	This miRNA sequence was predicted based on homology to a verified miRNAfrom mouse . Michael et al. subsequently verified expression ofmiR-15b in human .
	MIPF0001858		MIMAT000458
MI0000069	MIPF0000006	CCUUGGAGUAAAGUAGCAGCACAUAAUGGUUUGUGGAUUUUGAAAAGGUGCAGGCCAUAUUGUGCUGCCUCAAAAAUACAAGG	MIMAT0000068 hsa-miR-15a-5p	UAGCAGCACAUAAUGGUUUGUG	Reference named this sequence miR-15. This is renamed miR-15a here toavoid confusion with miR-15b (MIR:MI0000438) identified later by others.This gene and miR-16 are clustered within 0.5 kb at 13q14. This regionhas been shown to be deleted in more than half of B cell chroniclymphocytic leukemias (CLL). Both miR-15a and miR-16 are deleted ordown-regulated in more than two thirds of CLL cases .
MI0000069	MIPF0000006	CCUUGGAGUAAAGUAGCAGCACAUAAUGGUUUGUGGAUUUUGAAAAGGUGCAGGCCAUAUUGUGCUGCCUCAAAAAUACAAGG	MIMAT0004488 hsa-miR-15a-3p	CAGGCCAUAUUGUGCUGCCUCA	Reference named this sequence miR-15. This is renamed miR-15a here toavoid confusion with miR-15b (MIR:MI0000438) identified later by others.This gene and miR-16 are clustered within 0.5 kb at 13q14. This regionhas been shown to be deleted in more than half of B cell chroniclymphocytic leukemias (CLL). Both miR-15a and miR-16 are deleted ordown-regulated in more than two thirds of CLL cases .
MI0000438	MIPF0000006	UUGAGGCCUUAAAGUACUGUAGCAGCACAUCAUGGUUUACAUGCUACAGUCAAGAUGCGAAUCAUUAUUUGCUGCUCUAGAAAUUUAAGGAAAUUCAU	MIMAT0000417 hsa-miR-15b-5p	UAGCAGCACAUCAUGGUUUACA	This miRNA sequence was predicted based on homology to a verified miRNAfrom mouse . Michael et al. subsequently verified expression ofmiR-15b in human .
	MIPF0001858		MIMAT000458
MI0000069	MIPF0000006	CCUUGGAGUAAAGUAGCAGCACAUAAUGGUUUGUGGAUUUUGAAAAGGUGCAGGCCAUAUUGUGCUGCCUCAAAAAUACAAGG	MIMAT0000068 hsa-miR-15a-5p	UAGCAGCACAUAAUGGUUUGUG	Reference named this sequence miR-15. This is renamed miR-15a here toavoid confusion with miR-15b (MIR:MI0000438) identified later by others.This gene and miR-16 are clustered within 0.5 kb at 13q14. This regionhas been shown to be deleted in more than half of B cell chroniclymphocytic leukemias (CLL). Both miR-15a and miR-16 are deleted ordown-regulated in more than two thirds of CLL cases .
MI0000069	MIPF0000006	CCUUGGAGUAAAGUAGCAGCACAUAAUGGUUUGUGGAUUUUGAAAAGGUGCAGGCCAUAUUGUGCUGCCUCAAAAAUACAAGG	MIMAT0004488 hsa-miR-15a-3p	CAGGCCAUAUUGUGCUGCCUCA	Reference named this sequence miR-15. This is renamed miR-15a here toavoid confusion with miR-15b (MIR:MI0000438) identified later by others.This gene and miR-16 are clustered within 0.5 kb at 13q14. This regionhas been shown to be deleted in more than half of B cell chroniclymphocytic leukemias (CLL). Both miR-15a and miR-16 are deleted ordown-regulated in more than two thirds of CLL cases .
MI0000438	MIPF0000006	UUGAGGCCUUAAAGUACUGUAGCAGCACAUCAUGGUUUACAUGCUACAGUCAAGAUGCGAAUCAUUAUUUGCUGCUCUAGAAAUUUAAGGAAAUUCAU	MIMAT0000417 hsa-miR-15b-5p	UAGCAGCACAUCAUGGUUUACA	This miRNA sequence was predicted based on homology to a verified miRNAfrom mouse . Michael et al. subsequently verified expression ofmiR-15b in human .
	MIPF0001858		MIMAT000458

link to database

TargetScanS 6.2 | MicroCosm | microRNA.org | miRNAMap 2.0

Interacted genes from RAID,miRTarBase

RECK,TGOLN2,ITGA6,DHX37,TNPO3,FOXK1,FASN,BEX1,PLA2G2D,EIF2AK2,WAC,CNN3,PMS1,MLL2,HSP90AB1
more » RECK,TGOLN2,ITGA6,DHX37,TNPO3,FOXK1,FASN,BEX1,PLA2G2D,EIF2AK2,WAC,CNN3,PMS1,MLL2,HSP90AB1,HSP90B1,BACE1,ADORA2B,UBE3B,EIF4A1,SLC35B3,FBXO30,C2orf74,RND2,NUP210,NT5DC1,CDK4,VEGFA,ODC1,FOXO1,PSMD7,HDHD2,ND4L,ARID2,FGF5,TARDBP,IFNG,CLCN3,LEPROTL1,APRT,SEC63,TTC1,BTAF1,RPLP0,SLC1A5,AGPAT5,H3F3B,LSM14A,BMI1,ELN,B4GALT1,GDI2,MSH2,ANAPC16,RSPO2,NAB1,TRAPPC1,ACVR1B,TRIM28,HACE1,TMC7,FADD,DDX5,PURA,ATP6AP1,PPIL1,MLL3,CYBA,ATP6V0E1,BRAT1,CDC14B,RBM27,CADM1,ZNRF1,PDHX,GCLM,RAE1,UACA,NUP160,SYNJ1,GOLGA5,HSPA8,TFAM,STT3B,SERBP1,PTAR1,CNOT6,ETNK1,HSPA1A,APP,CCND1,ATP2A2,AP2M1,HNRNPM,QRICH1,AKT3,MAPK6,BTRC,FAM115C,PIK3C2B,PPTC7,SEPT2,ASXL2,GTF2H1,PGD,UGP2,UCP2,VPS35,HRSP12,OMA1,MTMR6,NUP214,C1orf43,C20orf29,CD44,ECHS1,RPS3A,NDFIP1,MYCBP2,FAM122C,ZNF217,RNF149,PRPS1,FAM69A,XKR9,QARS,MAP2K4,LIN28B,RASAL2,CHUK,ZCCHC14,DHX57,JAK1,MPP1,RHOT1,PRDX3,HNRNPH3,NOP2,NFKB1,RAB9B,DMTF1,BCL2,VOPP1,VPS13A,RLIM,WIPF1,TPD52,KIF1A,TAB2,C17orf80,MRPS11,WT1,PHLDB3,NAA30,TMEM214,CCNYL1,NPM1,CCNE1,ZNF559,RNASEL,RPS3,PDCD4,MYB,AIG1,AMMECR1L,SFT2D1,CLCN6,DHX30,SLC39A14,IKBKG,MN1,RGPD5,HIST1H2BK,SMAD7,WNT3A,MPHOSPH9,TP53,TM9SF3,PPT1,DSTYK,MLLT4,FAM214A,PPP1CC,AP4S1,TMCO7,HNRNPK,PDCD6IP,RPS6,PRIM1,DNAJC5,PXMP2,HERC6,MESDC2,KIAA1530,CCND2,IFNGR2,CABIN1,IFIH1,FANCC,THRA,VDAC2,PCMT1,INADL,RAD51C,PLSCR4,TSPAN3,CKAP5,SUPT3H,SKAP2,BRWD1,GNL3L,MCPH1,HIST2H3A,CLCC1,POU2F1,PCF11,MAPK1,VPS45,CARD8,SLC35A1,EIF5B,SNX6,MCL1,CRK,JUN,TMEM63B,STXBP1,CDC25A,PTPRF,MDH1,CREBL2,RPP30,RAB21,CEP63,ATF2,C6orf168,COIL,TPI1,FBXO3,CALD1,SF3B3,TXLNA,MYBL1,BRCA1,OSGEPL1,LZTR1,CHEK1,PPIL2,PREB,DLK1,ASNSD1,PSMC4,ACTR1A,DENR,CHD4,CPOX,CHMP7,PHKB,ZFAND5,HSDL2,BAMBI,TSPYL2,RAB1B,TERF2,SCCPDH,URB2,AIFM2,CRKL,MARCKS,TMEM43,PTBP1,PNN,TCP1,PPP1CB,EEF1A1,CENPJ,TBRG4,RPL27A,LRRC41,TMEM184B,UGDH,CHPF,CYP51A1,TIA1,C14orf109,NRIP1,RANBP10,CCT6B,EDC4,ECHDC1,CIAO1,GOLPH3L,DSG2,C5orf15

KEGG pathways enriched for interacted genes

pathway name

pathway description

target genes enrich in pathway

p-value

hsa05200	Pathways in cancer	JUN,CCND1,WNT3A,IKBKG,BCL2,CHUK,FOXO1,ACVR1B,MSH2,CDK4,JAK1,FGF5,HSP90AB1,TP53,CRK,CRKL,FADD,AKT3,VEGFA,NFKB1,CCNE1,ITGA6,HSP90B1,MAPK1,	3.84E-7
hsa05212	Pancreatic cancer	CCND1,IKBKG,AKT3,CHUK,VEGFA,ACVR1B,CDK4,NFKB1,JAK1,TP53,MAPK1,	2.82E-6
hsa05215	Prostate cancer	CCND1,IKBKG,BCL2,AKT3,CHUK,FOXO1,NFKB1,HSP90AB1,CCNE1,HSP90B1,TP53,MAPK1,	2.85E-6
hsa05220	Chronic myeloid leukemia	CRK,CCND1,IKBKG,CRKL,AKT3,CHUK,ACVR1B,CDK4,NFKB1,TP53,MAPK1,	4.12E-6
hsa05222	Small cell lung cancer	CCND1,IKBKG,BCL2,AKT3,CHUK,CDK4,NFKB1,CCNE1,ITGA6,TP53,	7.61E-5

hsa04010	MAPK signaling pathway	JUN,IKBKG,CHUK,HSPA1A,ACVR1B,HSPA8,FGF5,TP53,CRK,MAP2K4,CRKL,AKT3,PLA2G2D,ATF2,TAB2,NFKB1,MAPK1,	1.90E-4
hsa04621	NOD-like receptor signaling pathway	IKBKG,CHUK,CARD8,TAB2,NFKB1,HSP90AB1,HSP90B1,MAPK1,	3.56E-4
hsa04910	Insulin signaling pathway	CRK,CRKL,AKT3,FASN,PHKB,FOXO1,PPP1CC,PTPRF,PPP1CB,RPS6,MAPK1,	6.55E-4
hsa04620	Toll-like receptor signaling pathway	JUN,MAP2K4,IKBKG,AKT3,FADD,CHUK,TAB2,NFKB1,MAPK1,	1.49E-2
hsa05210	Colorectal cancer	JUN,CCND1,BCL2,AKT3,ACVR1B,MSH2,TP53,MAPK1,	2.21E-2
hsa05120	Epithelial cell signaling in Helicobacter pylori infection	JUN,MAP2K4,IKBKG,CHUK,ATP6V0E1,ATP6AP1,NFKB1,	3.44E-2
hsa04510	Focal adhesion	CRK,JUN,CCND1,CRKL,BCL2,AKT3,VEGFA,PPP1CC,PPP1CB,CCND2,ITGA6,MAPK1,	4.13E-2
hsa05221	Acute myeloid leukemia	CCND1,IKBKG,AKT3,CHUK,NFKB1,MAPK1,	8.27E-2
hsa04660	T cell receptor signaling pathway	JUN,IFNG,IKBKG,AKT3,CHUK,CDK4,NFKB1,MAPK1,	8.90E-2
hsa04210	Apoptosis	IKBKG,BCL2,AKT3,FADD,CHUK,NFKB1,TP53,	1.13E-1
hsa05219	Bladder cancer	CCND1,VEGFA,CDK4,TP53,MAPK1,	1.27E-1
hsa04115	p53 signaling pathway	CCND1,CHEK1,CCND2,CDK4,CCNE1,TP53,	1.58E-1
hsa05211	Renal cell carcinoma	CRK,JUN,CRKL,AKT3,VEGFA,MAPK1,	1.77E-1
hsa04722	Neurotrophin signaling pathway	CRK,JUN,CRKL,BCL2,AKT3,NFKB1,TP53,MAPK1,	1.81E-1
hsa05218	Melanoma	CCND1,AKT3,CDK4,FGF5,TP53,MAPK1,	1.88E-1
hsa04110	Cell cycle	CCND1,CDC14B,CDC25A,CHEK1,CCND2,CDK4,CCNE1,TP53,	1.88E-1
hsa04662	B cell receptor signaling pathway	JUN,IKBKG,AKT3,CHUK,NFKB1,MAPK1,	2.32E-1
hsa05223	Non-small cell lung cancer	CCND1,AKT3,CDK4,TP53,MAPK1,	2.94E-1
hsa04012	ErbB signaling pathway	CRK,JUN,MAP2K4,CRKL,AKT3,MAPK1,	4.06E-1
hsa05214	Glioma	CCND1,AKT3,CDK4,TP53,MAPK1,	4.79E-1
hsa03040	Spliceosome	HNRNPM,HSPA1A,DDX5,HNRNPK,SF3B3,HSPA8,PPIL1,	5.64E-1
hsa04622	RIG-I-like receptor signaling pathway	IFIH1,IKBKG,FADD,CHUK,NFKB1,	6.85E-1
hsa04270	Vascular smooth muscle contraction	PLA2G2D,PPP1CC,CALD1,ADORA2B,PPP1CB,MAPK1,	9.70E-1

Gene ontology terms enriched for interacted genes

GO terms

GO terms description

target genes enrich in GO term

p-value

GO:0046907	intracellular transport	JUN,RAB9B,RHOT1,CHMP7,HSPA8,C6orf168,NUP160,WIPF1,ATP2A2,RGPD5,IFNG,UCP2,SNX6,VPS13A,AP4S1,ATP6AP1,TRAPPC1,PREB,RAE1,AP2M1,GOLGA5,NUP214,VPS35,BCL2,SEC63,NPM1,TP53,APP,VPS45,KIF1A,MAPK1,	2.05E-6
GO:0007049	cell cycle	BTRC,SEPT2,PSMD7,PDCD6IP,CENPJ,IFNG,CREBL2,MPHOSPH9,CKAP5,RAD51C,CCND1,TERF2,BCL2,BRCA1,NPM1,ACVR1B,CHEK1,CEP63,PSMC4,MSH2,TSPYL2,TBRG4,CDK4,TP53,APP,CDC25A,TARDBP,PPP1CC,PPP1CB,CCND2,MAPK6,DMTF1,CCNE1,MAPK1,	2.86E-6
GO:0042981	regulation of apoptosis	JUN,IFIH1,IKBKG,B4GALT1,RPS3A,PPT1,CD44,RPS3,IFNG,FADD,VEGFA,CARD8,DNAJC5,HSP90B1,AIFM2,CADM1,BCL2,UACA,FOXO1,BRCA1,GCLM,HSPA1A,NPM1,PTPRF,ACVR1B,MSH2,TP53,MCL1,APP,TIA1,PRDX3,NFKB1,RPS6,MAPK1,	6.09E-6
GO:0043067	regulation of programmed cell death	JUN,IFIH1,IKBKG,B4GALT1,RPS3A,PPT1,CD44,RPS3,IFNG,FADD,VEGFA,CARD8,DNAJC5,HSP90B1,AIFM2,CADM1,BCL2,UACA,FOXO1,BRCA1,GCLM,HSPA1A,NPM1,PTPRF,ACVR1B,MSH2,TP53,MCL1,APP,TIA1,PRDX3,NFKB1,RPS6,MAPK1,	7.49E-6
GO:0010941	regulation of cell death	JUN,IFIH1,IKBKG,B4GALT1,RPS3A,PPT1,CD44,RPS3,IFNG,FADD,VEGFA,CARD8,DNAJC5,HSP90B1,AIFM2,CADM1,BCL2,UACA,FOXO1,BRCA1,GCLM,HSPA1A,NPM1,PTPRF,ACVR1B,MSH2,TP53,MCL1,APP,TIA1,PRDX3,NFKB1,RPS6,MAPK1,	8.10E-6

GO:0051329	interphase of mitotic cell cycle	CCND1,BCL2,CDC25A,PPP1CB,ACVR1B,CHEK1,CCND2,TBRG4,CDK4,CCNE1,APP,	1.47E-5
GO:0051325	interphase	CCND1,BCL2,CDC25A,PPP1CB,ACVR1B,CHEK1,CCND2,TBRG4,CDK4,CCNE1,APP,	1.90E-5
GO:0022402	cell cycle process	BTRC,SEPT2,PSMD7,CENPJ,IFNG,MPHOSPH9,CKAP5,RAD51C,CCND1,BCL2,NPM1,BRCA1,ACVR1B,CEP63,PSMC4,MSH2,CHEK1,TBRG4,CDK4,TP53,APP,TARDBP,CDC25A,PPP1CB,CCND2,CCNE1,	2.61E-5
GO:0051726	regulation of cell cycle	JUN,CCND1,BCL2,NPM1,BRCA1,CHEK1,MSH2,CEP63,TSPYL2,CDK4,HSPA8,TP53,PDCD4,APP,GTF2H1,CDC25A,PPP1CB,CCND2,MYCBP2,	2.73E-5
GO:0000082	G1/S transition of mitotic cell cycle	CCND1,BCL2,CDC25A,PPP1CB,ACVR1B,CCND2,CDK4,CCNE1,	5.75E-5
GO:0015031	protein transport	JUN,TNPO3,RAB9B,CHMP7,PPT1,C6orf168,NUP160,RAB21,RGPD5,PDCD6IP,IFNG,SFT2D1,SNX6,VPS13A,AP4S1,ATP6AP1,PREB,HSP90B1,AP2M1,STXBP1,NUP214,VPS35,NUP210,SEC63,NPM1,TP53,RAB1B,VPS45,GDI2,MAPK1,	9.14E-5
GO:0045184	establishment of protein localization	JUN,TNPO3,RAB9B,CHMP7,PPT1,C6orf168,NUP160,RAB21,RGPD5,PDCD6IP,IFNG,SFT2D1,SNX6,VPS13A,AP4S1,ATP6AP1,PREB,HSP90B1,AP2M1,STXBP1,NUP214,VPS35,NUP210,SEC63,NPM1,TP53,RAB1B,VPS45,GDI2,MAPK1,	1.07E-4
GO:0000278	mitotic cell cycle	CCND1,BCL2,ACVR1B,CHEK1,PSMC4,CEP63,BTRC,TBRG4,CDK4,SEPT2,PSMD7,APP,TARDBP,CDC25A,MPHOSPH9,PPP1CB,CCND2,CCNE1,CKAP5,	1.14E-4
GO:0033554	cellular response to stress	JUN,CCND1,TERF2,UACA,BCL2,ADORA2B,BRCA1,CHEK1,MSH2,CEP63,PMS1,EIF2AK2,RPS3,TP53,GTF2H1,MAP2K4,IFNG,CRKL,PRDX3,PPP1CB,MRPS11,FANCC,RAD51C,MAPK1,	1.98E-4
GO:0043523	regulation of neuron apoptosis	JUN,BCL2,PRDX3,PTPRF,GCLM,DNAJC5,MSH2,PPT1,TP53,	1.99E-4
GO:0043065	positive regulation of apoptosis	JUN,CADM1,IKBKG,UACA,BCL2,PTPRF,BRCA1,ACVR1B,B4GALT1,RPS3A,CD44,RPS3,TP53,APP,IFNG,FADD,TIA1,RPS6,AIFM2,MAPK1,	2.56E-4
GO:0010605	negative regulation of macromolecule metabolic process	JUN,LIN28B,PSMD7,WT1,RPS3,NRIP1,PDCD4,FOXK1,SNX6,THRA,TRIM28,NDFIP1,SMAD7,RLIM,BTAF1,TERF2,NPM1,BRCA1,PSMC4,MSH2,TSPYL2,HSP90AB1,TP53,PURA,TIA1,NAB1,POU2F1,NFKB1,	2.77E-4
GO:0043068	positive regulation of programmed cell death	JUN,CADM1,IKBKG,UACA,BCL2,PTPRF,BRCA1,ACVR1B,B4GALT1,RPS3A,CD44,RPS3,TP53,APP,IFNG,FADD,TIA1,RPS6,AIFM2,MAPK1,	2.80E-4
GO:0010942	positive regulation of cell death	JUN,CADM1,IKBKG,UACA,BCL2,PTPRF,BRCA1,ACVR1B,B4GALT1,RPS3A,CD44,RPS3,TP53,APP,IFNG,FADD,TIA1,RPS6,AIFM2,MAPK1,	2.95E-4
GO:0045934	negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	TERF2,BRCA1,NPM1,MSH2,TSPYL2,WT1,RPS3,PDCD4,NRIP1,TP53,FOXK1,PURA,SNX6,NAB1,THRA,POU2F1,NFKB1,TRIM28,NDFIP1,SMAD7,RLIM,BTAF1,	3.34E-4
GO:0051172	negative regulation of nitrogen compound metabolic process	TERF2,BRCA1,NPM1,MSH2,TSPYL2,WT1,RPS3,PDCD4,NRIP1,TP53,FOXK1,PURA,SNX6,NAB1,THRA,POU2F1,NFKB1,TRIM28,NDFIP1,SMAD7,RLIM,BTAF1,	4.00E-4
GO:0008284	positive regulation of cell proliferation	JUN,CCND1,BCL2,CIAO1,NPM1,BMI1,B4GALT1,TBRG4,CDK4,PURA,IFNG,VEGFA,PRDX3,PPP1CB,CCND2,ATP6AP1,NOP2,ODC1,MAPK1,	4.49E-4
GO:0008104	protein localization	JUN,TNPO3,RAB9B,CHMP7,PPT1,C6orf168,NUP160,RAB21,RGPD5,PDCD6IP,IFNG,SFT2D1,SNX6,VPS13A,AP4S1,ATP6AP1,PREB,HSP90B1,AP2M1,STXBP1,NUP214,VPS35,NUP210,TERF2,SEC63,NPM1,TP53,RAB1B,VPS45,GDI2,MAPK1,	4.81E-4
GO:0006793	phosphorus metabolic process	CDC14B,CHUK,ADORA2B,DSTYK,EIF2AK2,ND4L,MAP2K4,MTMR6,IFNG,ATP6V0E1,ATP6AP1,PIK3C2B,TRIM28,RNASEL,SMAD7,GOLGA5,CCND1,BCL2,PTPRF,ACVR1B,CHEK1,MSH2,CDK4,JAK1,APP,AKT3,UGP2,CDC25A,PPP1CC,PPP1CB,MAPK6,SYNJ1,MAPK1,	5.53E-4
GO:0006796	phosphate metabolic process	CDC14B,CHUK,ADORA2B,DSTYK,EIF2AK2,ND4L,MAP2K4,MTMR6,IFNG,ATP6V0E1,ATP6AP1,PIK3C2B,TRIM28,RNASEL,SMAD7,GOLGA5,CCND1,BCL2,PTPRF,ACVR1B,CHEK1,MSH2,CDK4,JAK1,APP,AKT3,UGP2,CDC25A,PPP1CC,PPP1CB,MAPK6,SYNJ1,MAPK1,	5.53E-4
GO:0051053	negative regulation of DNA metabolic process	TERF2,MSH2,TSPYL2,NDFIP1,RPS3,TP53,	6.04E-4
GO:0032268	regulation of cellular protein metabolic process	JUN,CCND1,BCL2,HRSP12,BRCA1,PSMC4,BTRC,CDK4,PSMD7,HSP90AB1,EIF5B,PDCD4,APP,IFNG,TIA1,CCND2,NFKB1,NDFIP1,SMAD7,MAPK1,	8.58E-4
GO:0051052	regulation of DNA metabolic process	JUN,IFNG,TERF2,BRCA1,MSH2,TSPYL2,NDFIP1,RPS3,TP53,	9.81E-4
GO:0000077	DNA damage checkpoint	CCND1,BRCA1,CHEK1,CEP63,MSH2,TP53,	1.57E-2
GO:0042127	regulation of cell proliferation	JUN,BMI1,B4GALT1,EIF2AK2,IFNG,VEGFA,ATP6AP1,NDFIP1,CCND1,BCL2,CIAO1,FOXO1,NPM1,PTPRF,BRCA1,CHEK1,TBRG4,CDK4,SKAP2,TP53,PURA,PRDX3,PPP1CB,CCND2,NOP2,ODC1,MAPK1,	1.75E-2
GO:0051453	regulation of intracellular pH	CLCN3,ATP6V0E1,PPT1,TP53,	1.75E-2
GO:0043524	negative regulation of neuron apoptosis	BCL2,PRDX3,GCLM,DNAJC5,MSH2,PPT1,	2.07E-2
GO:0031570	DNA integrity checkpoint	CCND1,BRCA1,CHEK1,CEP63,MSH2,TP53,	2.26E-2
GO:0051301	cell division	CCND1,CDC14B,WNT3A,CEP63,SEPT2,CDK4,PDCD6IP,CENPJ,CDC25A,PPP1CC,PPP1CB,CCND2,CKAP5,CCNE1,	2.50E-2
GO:0030641	regulation of cellular pH	CLCN3,ATP6V0E1,PPT1,TP53,	2.63E-2
GO:0000079	regulation of cyclin-dependent protein kinase activity	CCND1,GTF2H1,CDC25A,PPP1CB,CHEK1,CCND2,	2.67E-2
GO:0007569	cell aging	TERF2,BCL2,NPM1,PDCD4,TP53,	2.67E-2
GO:0010604	positive regulation of macromolecule metabolic process	JUN,BTRC,PSMD7,WT1,NRIP1,FOXK1,IFNG,VEGFA,THRA,TRIM28,NDFIP1,SMAD7,CCND1,TERF2,BCL2,FOXO1,BRCA1,PSMC4,CDK4,TP53,APP,GTF2H1,DDX5,CCND2,POU2F1,NFKB1,CCNE1,MAPK1,	2.80E-2
GO:0006974	response to DNA damage stimulus	CCND1,TERF2,UACA,BRCA1,CHEK1,MSH2,CEP63,PMS1,RPS3,TP53,GTF2H1,PPP1CB,MRPS11,FANCC,RAD51C,MAPK1,	2.84E-2
GO:0000060	protein import into nucleus, translocation	JUN,IFNG,ATP6AP1,TP53,MAPK1,	2.99E-2
GO:0042770	DNA damage response, signal transduction	CCND1,UACA,BRCA1,CHEK1,CEP63,MSH2,TP53,	3.00E-2
GO:0022403	cell cycle phase	CCND1,BCL2,ACVR1B,CHEK1,CEP63,TBRG4,SEPT2,CDK4,APP,TARDBP,CDC25A,MPHOSPH9,PPP1CB,CCND2,CCNE1,CKAP5,RAD51C,	3.07E-2
GO:0032270	positive regulation of cellular protein metabolic process	CCND1,IFNG,BCL2,BRCA1,PSMC4,CCND2,BTRC,CDK4,PSMD7,NDFIP1,SMAD7,MAPK1,	3.09E-2
GO:0006984	ER-nuclear signaling pathway	CCND1,IFNG,EIF2AK2,TP53,ATP2A2,	3.33E-2
GO:0007568	aging	JUN,TERF2,BCL2,NPM1,MSH2,ATP6AP1,PDCD4,TP53,	3.50E-2
GO:0008406	gonad development	CCND1,BCL2,VEGFA,MSH2,CCND2,CCNE1,WT1,NRIP1,	3.87E-2
GO:0019725	cellular homeostasis	JUN,CLCN6,BCL2,CLCN3,GCLM,NPM1,RHOT1,PPT1,TP53,APP,ATP2A2,MCL1,PRDX3,NAB1,ATP6V0E1,NDFIP1,HSP90B1,SMAD7,	4.16E-2
GO:0042325	regulation of phosphorylation	JUN,CCND1,IKBKG,BCL2,NPM1,ADORA2B,CHEK1,TSPYL2,PDCD4,APP,GTF2H1,IFNG,CDC25A,PRDX3,PPP1CB,SNX6,CCND2,SMAD7,	4.16E-2
GO:0051247	positive regulation of protein metabolic process	CCND1,IFNG,BCL2,BRCA1,PSMC4,CCND2,BTRC,CDK4,PSMD7,NDFIP1,SMAD7,MAPK1,	4.25E-2
GO:0032844	regulation of homeostatic process	IFNG,TERF2,BCL2,VEGFA,GCLM,ACVR1B,CD44,SMAD7,	4.27E-2
GO:0016310	phosphorylation	CHUK,ADORA2B,DSTYK,EIF2AK2,MAP2K4,ND4L,IFNG,ATP6V0E1,ATP6AP1,PIK3C2B,TRIM28,SMAD7,RNASEL,GOLGA5,CCND1,BCL2,ACVR1B,MSH2,CHEK1,CDK4,JAK1,APP,AKT3,UGP2,MAPK6,MAPK1,	4.44E-2
GO:0006457	protein folding	TTC1,SEC63,DNAJC5,PPIL2,HSPA8,TCP1,HSP90AB1,PPIL1,HSP90B1,CCT6B,	4.47E-2
GO:0010608	posttranscriptional regulation of gene expression	BCL2,VEGFA,HRSP12,TIA1,SERBP1,LIN28B,CDK4,EIF5B,SMAD7,APP,MAPK1,	4.61E-2
GO:0006915	apoptosis	JUN,CADM1,BCL2,BRCA1,MSH2,RHOT1,TBRG4,PPT1,EIF2AK2,RPS3,TP53,PDCD4,APP,MCL1,PDCD6IP,IFNG,FADD,TIA1,CARD8,NFKB1,AIFM2,	5.56E-2
GO:0007548	sex differentiation	CCND1,BCL2,VEGFA,B4GALT1,MSH2,CCND2,CCNE1,WT1,NRIP1,	5.65E-2
GO:0019220	regulation of phosphate metabolic process	JUN,CCND1,IKBKG,BCL2,NPM1,ADORA2B,CHEK1,TSPYL2,PDCD4,APP,GTF2H1,IFNG,CDC25A,PRDX3,PPP1CB,SNX6,CCND2,SMAD7,	6.17E-2
GO:0051174	regulation of phosphorus metabolic process	JUN,CCND1,IKBKG,BCL2,NPM1,ADORA2B,CHEK1,TSPYL2,PDCD4,APP,GTF2H1,IFNG,CDC25A,PRDX3,PPP1CB,SNX6,CCND2,SMAD7,	6.17E-2
GO:0031401	positive regulation of protein modification process	CCND1,IFNG,BCL2,BRCA1,PSMC4,CCND2,BTRC,PSMD7,NDFIP1,SMAD7,	6.37E-2
GO:0012501	programmed cell death	JUN,CADM1,BCL2,BRCA1,MSH2,RHOT1,TBRG4,PPT1,EIF2AK2,RPS3,TP53,PDCD4,APP,MCL1,PDCD6IP,IFNG,FADD,TIA1,CARD8,NFKB1,AIFM2,	6.50E-2
GO:0016071	mRNA metabolic process	HNRNPM,PNN,PCF11,HSPA1A,SERBP1,SF3B3,PPIL1,PTBP1,APP,HNRNPH3,VEGFA,TARDBP,DDX5,HNRNPK,RNASEL,	6.59E-2
GO:0006913	nucleocytoplasmic transport	NUP214,JUN,IFNG,NPM1,ATP6AP1,NUP160,RAE1,TP53,MAPK1,	6.85E-2
GO:0048608	reproductive structure development	CCND1,BCL2,VEGFA,MSH2,CCND2,CCNE1,WT1,NRIP1,	7.33E-2
GO:0051169	nuclear transport	NUP214,JUN,IFNG,NPM1,ATP6AP1,NUP160,RAE1,TP53,MAPK1,	7.37E-2
GO:0030004	cellular monovalent inorganic cation homeostasis	CLCN3,ATP6V0E1,PPT1,TP53,	7.59E-2
GO:0045137	development of primary sexual characteristics	CCND1,BCL2,VEGFA,MSH2,CCND2,CCNE1,WT1,NRIP1,	7.65E-2
GO:0050657	nucleic acid transport	RGPD5,NUP214,NUP210,NPM1,NUP160,CKAP5,RAE1,	7.71E-2
GO:0050658	RNA transport	RGPD5,NUP214,NUP210,NPM1,NUP160,CKAP5,RAE1,	7.71E-2
GO:0051236	establishment of RNA localization	RGPD5,NUP214,NUP210,NPM1,NUP160,CKAP5,RAE1,	7.71E-2
GO:0042592	homeostatic process	JUN,TERF2,CLCN6,IKBKG,BCL2,CLCN3,GCLM,NPM1,RHOT1,PPT1,TP53,MCL1,ATP2A2,APP,IFNG,VEGFA,PRDX3,NAB1,ATP6V0E1,FANCC,NDFIP1,HSP90B1,RPS6,SMAD7,	7.94E-2
GO:0045737	positive regulation of cyclin-dependent protein kinase activity	CCND1,PPP1CB,CCND2,	8.24E-2
GO:0006986	response to unfolded protein	CCND1,IFNG,HSPA1A,HSPA8,HSP90AB1,EIF2AK2,	8.63E-2
GO:0010629	negative regulation of gene expression	BRCA1,LIN28B,WT1,NRIP1,TP53,PDCD4,FOXK1,PURA,SNX6,NAB1,THRA,POU2F1,NFKB1,TRIM28,NDFIP1,SMAD7,RLIM,BTAF1,	8.75E-2
GO:0006403	RNA localization	RGPD5,NUP214,NUP210,NPM1,NUP160,CKAP5,RAE1,	8.90E-2
GO:0010558	negative regulation of macromolecule biosynthetic process	TERF2,BRCA1,TSPYL2,WT1,NRIP1,TP53,PDCD4,FOXK1,PURA,TIA1,SNX6,NAB1,THRA,POU2F1,NFKB1,TRIM28,SMAD7,RLIM,BTAF1,	9.13E-2
GO:0008219	cell death	JUN,CADM1,BCL2,BRCA1,MSH2,RHOT1,TBRG4,PPT1,EIF2AK2,RPS3,TP53,PDCD4,APP,MCL1,PDCD6IP,IFNG,FADD,TIA1,TARDBP,CARD8,ATP6AP1,NFKB1,AIFM2,	9.57E-2
GO:0016265	death	JUN,CADM1,BCL2,BRCA1,MSH2,RHOT1,TBRG4,PPT1,EIF2AK2,RPS3,TP53,PDCD4,APP,MCL1,PDCD6IP,IFNG,FADD,TIA1,TARDBP,CARD8,ATP6AP1,NFKB1,AIFM2,	1.00E-1

KEGG pathways and Gene Ontology terms enriched for the interacted genes of ncRNA from RAID and miRTarBase.

disease name	related genes	p-value