ncRNADetailInformation

Detail Information
Functional analysis

miRNA name

pre-miRNA

family

pre-miRNA Sequence

mature-miRNA

mature sequence

pre-miRNA description

miR-138

MI0000476	MIPF0000075	CCCUGGCAUGGUGUGGUGGGGCAGCUGGUGUUGUGAAUCAGGCCGUUGCCAAUCAGAGAACGGCUACUUCACAACACCAGGGCCACACCACACUACAGG	MIMAT0000430 hsa-miR-138-5p	AGCUGGUGUUGUGAAUCAGGCCG	This miRNA sequence is predicted based on homology to a verified miRNAfrom mouse . Expression in human was later validated by cloning .
MI0000455	MIPF0000075	CGUUGCUGCAGCUGGUGUUGUGAAUCAGGCCGACGAGCAGCGCAUCCUCUUACCCGGCUAUUUCACGACACCAGGGUUGCAUCA	MIMAT0004596 hsa-miR-138-2-3p	GCUAUUUCACGACACCAGGGUU	The mature sequence shown here represents the most commonly cloned formfrom large-scale cloning studies .
MI0000476	MIPF0000075	CCCUGGCAUGGUGUGGUGGGGCAGCUGGUGUUGUGAAUCAGGCCGUUGCCAAUCAGAGAACGGCUACUUCACAACACCAGGGCCACACCACACUACAGG	MIMAT0004607 hsa-miR-138-1-3p	GCUACUUCACAACACCAGGGCC	This miRNA sequence is predicted based on homology to a verified miRNAfrom mouse . Expression in human was later validated by cloning .
MI0000476	MIPF0000075	CCCUGGCAUGGUGUGGUGGGGCAGCUGGUGUUGUGAAUCAGGCCGUUGCCAAUCAGAGAACGGCUACUUCACAACACCAGGGCCACACCACACUACAGG	MIMAT0000430 hsa-miR-138-5p	AGCUGGUGUUGUGAAUCAGGCCG	This miRNA sequence is predicted based on homology to a verified miRNAfrom mouse . Expression in human was later validated by cloning .
MI0000455	MIPF0000075	CGUUGCUGCAGCUGGUGUUGUGAAUCAGGCCGACGAGCAGCGCAUCCUCUUACCCGGCUAUUUCACGACACCAGGGUUGCAUCA	MIMAT0004596 hsa-miR-138-2-3p	GCUAUUUCACGACACCAGGGUU	The mature sequence shown here represents the most commonly cloned formfrom large-scale cloning studies .
MI0000476	MIPF0000075	CCCUGGCAUGGUGUGGUGGGGCAGCUGGUGUUGUGAAUCAGGCCGUUGCCAAUCAGAGAACGGCUACUUCACAACACCAGGGCCACACCACACUACAGG	MIMAT0004607 hsa-miR-138-1-3p	GCUACUUCACAACACCAGGGCC	This miRNA sequence is predicted based on homology to a verified miRNAfrom mouse . Expression in human was later validated by cloning .
MI0000476	MIPF0000075	CCCUGGCAUGGUGUGGUGGGGCAGCUGGUGUUGUGAAUCAGGCCGUUGCCAAUCAGAGAACGGCUACUUCACAACACCAGGGCCACACCACACUACAGG	MIMAT0000430 hsa-miR-138-5p	AGCUGGUGUUGUGAAUCAGGCCG	This miRNA sequence is predicted based on homology to a verified miRNAfrom mouse . Expression in human was later validated by cloning .
MI0000455	MIPF0000075	CGUUGCUGCAGCUGGUGUUGUGAAUCAGGCCGACGAGCAGCGCAUCCUCUUACCCGGCUAUUUCACGACACCAGGGUUGCAUCA	MIMAT0004596 hsa-miR-138-2-3p	GCUAUUUCACGACACCAGGGUU	The mature sequence shown here represents the most commonly cloned formfrom large-scale cloning studies .
MI0000476	MIPF0000075	CCCUGGCAUGGUGUGGUGGGGCAGCUGGUGUUGUGAAUCAGGCCGUUGCCAAUCAGAGAACGGCUACUUCACAACACCAGGGCCACACCACACUACAGG	MIMAT0004607 hsa-miR-138-1-3p	GCUACUUCACAACACCAGGGCC	This miRNA sequence is predicted based on homology to a verified miRNAfrom mouse . Expression in human was later validated by cloning .

link to database

TargetScanS 6.2 | MicroCosm | microRNA.org | miRNAMap 2.0

Interacted genes from RAID,miRTarBase

EID1,EZH2,SNAI2,PLEK2,ABL1,MMP3,SIRT1,DMKN,SLC45A3,ROCK2,PPP1R13B,SUZ12,H2AFX,ZEB2,ARHGEF3
more » EID1,EZH2,SNAI2,PLEK2,ABL1,MMP3,SIRT1,DMKN,SLC45A3,ROCK2,PPP1R13B,SUZ12,H2AFX,ZEB2,ARHGEF3,CCND3,PTK2,SOX4,FOSL1,RARA,EIF2C1,CEBPA,RHOC,PHKG2,CDH2,CDH1,TOR2A,MTTP,EED,PPARG,HIST1H2BK,VIM,LPL,HIF1A,BLCAP,TERT,RELN,MXD1,NVL,RGS12,MST1,FABP4,IGF1R,SERPINE1,HIST1H2BJ,GNAI2

KEGG pathways enriched for interacted genes

pathway name

pathway description

target genes enrich in pathway

p-value

hsa05200	Pathways in cancer	CEBPA,IGF1R,PTK2,HIF1A,RARA,ABL1,PPARG,CASP3,CDH1,	3.95E-5
hsa04510	Focal adhesion	IGF1R,PTK2,RELN,ROCK2,CCND3,	9.89E-2
hsa04360	Axon guidance	GNAI2,PTK2,ABL1,ROCK2,	1.72E-1
hsa05130	Pathogenic Escherichia coli infection	ABL1,ROCK2,CDH1,	2.47E-1
hsa04115	p53 signaling pathway	CASP3,SERPINE1,CCND3,	3.42E-1

Gene ontology terms enriched for interacted genes

GO terms

GO terms description

target genes enrich in GO term

p-value

GO:0010629	negative regulation of gene expression	CEBPA,EID1,EED,FABP4,SUZ12,EIF2C1,PPARG,SNAI2,ZEB2,SIRT1,	2.84E-5
GO:0042127	regulation of cell proliferation	CEBPA,IGF1R,GNAI2,FABP4,SUZ12,SOX4,HIF1A,PPARG,FOSL1,SIRT1,CASP3,SERPINE1,	3.14E-5
GO:0010558	negative regulation of macromolecule biosynthetic process	CEBPA,EID1,EED,FABP4,SUZ12,EIF2C1,PPARG,SNAI2,ZEB2,SIRT1,	5.40E-5
GO:0031327	negative regulation of cellular biosynthetic process	CEBPA,EID1,EED,FABP4,SUZ12,EIF2C1,PPARG,SNAI2,ZEB2,SIRT1,	6.57E-5
GO:0009890	negative regulation of biosynthetic process	CEBPA,EID1,EED,FABP4,SUZ12,EIF2C1,PPARG,SNAI2,ZEB2,SIRT1,	7.73E-5

GO:0016481	negative regulation of transcription	CEBPA,EID1,EED,FABP4,SUZ12,PPARG,SNAI2,ZEB2,SIRT1,	9.99E-5
GO:0045934	negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	CEBPA,EID1,EED,FABP4,SUZ12,PPARG,SNAI2,ZEB2,SIRT1,	2.12E-4
GO:0050872	white fat cell differentiation	FABP4,PPARG,SIRT1,	2.14E-4
GO:0051172	negative regulation of nitrogen compound metabolic process	CEBPA,EID1,EED,FABP4,SUZ12,PPARG,SNAI2,ZEB2,SIRT1,	2.32E-4
GO:0010605	negative regulation of macromolecule metabolic process	CEBPA,EID1,EED,FABP4,SUZ12,EIF2C1,PPARG,SNAI2,ZEB2,SIRT1,	4.95E-4
GO:0055088	lipid homeostasis	LPL,MTTP,FABP4,PPARG,	5.99E-4
GO:0045444	fat cell differentiation	CEBPA,FABP4,PPARG,SIRT1,	6.71E-4
GO:0051276	chromosome organization	EZH2,TERT,EED,SUZ12,HIST1H2BK,H2AFX,HIST1H2BJ,SIRT1,	8.83E-4
GO:0042981	regulation of apoptosis	ARHGEF3,IGF1R,TERT,SOX4,ABL1,PPP1R13B,FOSL1,SIRT1,CASP3,CDH1,	9.54E-4
GO:0043067	regulation of programmed cell death	ARHGEF3,IGF1R,TERT,SOX4,ABL1,PPP1R13B,FOSL1,SIRT1,CASP3,CDH1,	1.02E-2
GO:0010941	regulation of cell death	ARHGEF3,IGF1R,TERT,SOX4,ABL1,PPP1R13B,FOSL1,SIRT1,CASP3,CDH1,	1.05E-2
GO:0051338	regulation of transferase activity	GNAI2,FABP4,PPARG,RELN,ZEB2,CASP3,CCND3,	1.21E-2
GO:0006325	chromatin organization	EZH2,EED,SUZ12,HIST1H2BK,H2AFX,HIST1H2BJ,SIRT1,	1.31E-2
GO:0008284	positive regulation of cell proliferation	IGF1R,GNAI2,FABP4,SUZ12,SOX4,HIF1A,FOSL1,	2.08E-2
GO:0006357	regulation of transcription from RNA polymerase II promoter	CEBPA,EID1,SUZ12,HIF1A,ABL1,PPARG,SNAI2,FOSL1,SIRT1,	2.11E-2
GO:0050873	brown fat cell differentiation	CEBPA,FABP4,PPARG,	2.72E-2
GO:0051726	regulation of cell cycle	H2AFX,PPP1R13B,FOSL1,CASP3,ROCK2,CCND3,	4.22E-2
GO:0045859	regulation of protein kinase activity	GNAI2,FABP4,RELN,ZEB2,CASP3,CCND3,	5.03E-2
GO:0006350	transcription	EZH2,SUZ12,SOX4,EIF2C1,HIF1A,RARA,SNAI2,PPARG,FOSL1,ZEB2,CEBPA,EID1,EED,MXD1,SIRT1,	5.24E-2
GO:0009991	response to extracellular stimulus	GNAI2,RARA,PPARG,FOSL1,SIRT1,	5.55E-2
GO:0045892	negative regulation of transcription, DNA-dependent	CEBPA,EID1,SUZ12,PPARG,SNAI2,SIRT1,	5.74E-2
GO:0045449	regulation of transcription	EZH2,SUZ12,FABP4,SOX4,EIF2C1,HIF1A,RARA,ABL1,SNAI2,PPARG,FOSL1,ZEB2,CEBPA,EID1,EED,MXD1,SIRT1,	5.79E-2
GO:0043549	regulation of kinase activity	GNAI2,FABP4,RELN,ZEB2,CASP3,CCND3,	5.80E-2
GO:0051253	negative regulation of RNA metabolic process	CEBPA,EID1,SUZ12,PPARG,SNAI2,SIRT1,	6.15E-2
GO:0043933	macromolecular complex subunit organization	IGF1R,LPL,PTK2,HIST1H2BK,H2AFX,HIST1H2BJ,CDH2,CDH1,	7.47E-2
GO:0010033	response to organic substance	IGF1R,MMP3,FABP4,RARA,PPARG,FOSL1,CASP3,CDH1,	8.11E-2
GO:0006641	triglyceride metabolic process	LPL,MTTP,SIRT1,	8.57E-2
GO:0006355	regulation of transcription, DNA-dependent	EZH2,SUZ12,SOX4,HIF1A,RARA,ABL1,SNAI2,PPARG,FOSL1,ZEB2,CEBPA,EID1,SIRT1,	9.23E-2
GO:0032583	regulation of gene-specific transcription	CEBPA,HIF1A,PPARG,SIRT1,	9.35E-2
GO:0009719	response to endogenous stimulus	IGF1R,MMP3,FABP4,RARA,PPARG,FOSL1,	9.76E-2
GO:0042592	homeostatic process	LPL,TERT,MTTP,FABP4,HIF1A,PPARG,CASP3,SERPINE1,	1.00E-1

KEGG pathways and Gene Ontology terms enriched for the interacted genes of ncRNA from RAID and miRTarBase.

disease name	related genes	p-value