ncRNADetailInformation

Detail Information
Functional analysis

miRNA name

pre-miRNA

family

pre-miRNA Sequence

mature-miRNA

mature sequence

pre-miRNA description

miR-125b-2

MI0000470	MIPF0000033	ACCAGACUUUUCCUAGUCCCUGAGACCCUAACUUGUGAGGUAUUUUAGUAACAUCACAAGUCAGGCUCUUGGGACCUAGGCGGAGGGGA	MIMAT0000423 hsa-miR-125b-5p	UCCCUGAGACCCUAACUUGUGA	This miRNA sequence is predicted based on homology to a verified miRNAfrom mouse . Its expression was later verified in human BC-1 cells.
MI0000470	MIPF0000033	ACCAGACUUUUCCUAGUCCCUGAGACCCUAACUUGUGAGGUAUUUUAGUAACAUCACAAGUCAGGCUCUUGGGACCUAGGCGGAGGGGA	MIMAT0004603 hsa-miR-125b-2-3p	UCACAAGUCAGGCUCUUGGGAC	This miRNA sequence is predicted based on homology to a verified miRNAfrom mouse . Its expression was later verified in human BC-1 cells.

link to database

TargetScanS 6.2 | MicroCosm | microRNA.org | miRNAMap 2.0

Interacted genes from RAID,miRTarBase

CREBBP,PPP1CA,EHMT1,SLC7A1,DGAT1,PABPC1,ACSS1,EPHA7,NDOR1,GRINA,MLL2,NRARP,CEP170,THUMPD1,HMGA2
more » CREBBP,PPP1CA,EHMT1,SLC7A1,DGAT1,PABPC1,ACSS1,EPHA7,NDOR1,GRINA,MLL2,NRARP,CEP170,THUMPD1,HMGA2,ATP5B,HUWE1,BAX,IRS4,TAF15,SLC19A1,SLC16A4,SLC9A3R2,HKR1,EIF5,RYBP,SNRPB,PRKAG1,MUC1,SDHB,ZDHHC5,NTRK3,C6orf162,TARDBP,GANAB,AKT1,PARP1,VDAC1,NKIRAS2,RPLP0,FBN1,PTGES,STRN3,KCNS3,NSUN2,USP22,CSTB,C1orf109,SLC35A4,TBC1D1,FBXO38,NUP93,CDKN2A,TMEM48,RAF1,CD320,MTMR4,KIAA1826,COX7C,EXTL3,FBXL20,ABHD15,ABL1,E2F7,NEBL,MED1,SIK2,DDX50,FGFR2,HIST2H2BF,NME2,ASH2L,BTBD3,RGS19,NNT,ZNF395,CCDC124,PPAT,SUGP2,MYO19,ATXN1,DHX38,BCKDK,MFHAS1,STC2,STAT3,HNF4G,KIF24,CHMP3,ND6,SMARCD2,RPS12,MTRF1L,ESRP2,WDR11,ILVBL,LSM14B,LTV1,WNK1,ZNF592,ZMYND11,IP6K1,MATR3,HTT,TDG,TMEM9,KRT7,FZD4,PAM,THAP3,ETS1,CNGB1,LYPLA2,MTMR12,PCDHGB2,UNKL,FAM60A,RNH1,ERBB2,GLI1,RPL29,FRAT2,RPL3,SMC6,UBA6,RPS3A,SMYD5,CDRT4,SSR3,PLEKHA8,PIP4K2C,RASAL2,LIN28B,RNF144A,RPS6KA1,MEPCE,C15orf39,DHX57,VDR,SEL1L,B4GALT3,GRIN2A,SHMT1,TEF,KHSRP,BCOR,MAPK14,GALNTL4,MKNK2,BCL2,HK2,SMO,SORT1,C17orf80,KLF13,MTF1,NPM1,CEBPA,CCNE1,EDEM1,SRRM2,BAK1,CARHSP1,BBC3,CHPF2,HNF4A,CRTC1,PSMB1,BACH1,SAMD10,SP7,MTA2,FAM91A1,ULK3,E2F3,RPS7,HBS1L,PIGF,SGPL1,PPM1H,CYP24A1,TIMM23,FMNL3,ABTB1,LSS,FAM208A,RMND5A,BCL2L13,TP53,TNKS1BP1,MMAB,CTDSP1,BMPR1B,CASC3,HNRNPK,IGF2,CSRNP2,MYEF2,LIF,LACTB,CBFB,RPL35A,LUC7L3,MRTO4,PTOV1,NDUFS7,EMD,FXR1,HSPBP1,SPEN,RHOV,CEBPG,RIMS4,ARF3,RNASEH2A,BCL3,AKAP2,GABRB3,NES,RFWD3,DYNC2H1,ERBB3,PSAT1,ZFYVE1,LIN28A,MMP13,STARD8,TMEM2,THRAP3,TIMM10,QSOX2,NUP205,NPTN,PDZD11,PRDX2,THUMPD3,PDS5A,FAT1,VCL,EIF4EBP1,KDELC2,SMG1,SUPT6H,HSPD1,MTMR3,XIAP,PABPC4,PMAIP1,PCBP2,C1orf124,SMC2,E2F2,PLA2G4F,RRP7A,GPRIN1,C19orf54,FUS,C2orf88,TNRC6B,TNFAIP3,USP8,R3HDM2,NRD1,KIAA0141,ARID3B,HMGA1,FAM199X,UBAP2L,HN1L,ABCC4,PRKRA,BMF,LBX2,ABCC1,ETF1,SEC24A,RANBP2,LTA4H,CMTM4,EXOC7,SLC7A6,IRF4,RPS28,KPNB1,CGN,S100A8,AURKB,TP53INP1,PKM2,ACLY,SYT2,EEF1A1,ZNF483,UNG,HDGF,MAP3K2,PPP1R12C,RASGRP1,KIAA0090,HOXA13,PRDM1,ADM,ADRM1,PLXND1,ZNF212,SLC25A1,HMGN1

KEGG pathways enriched for interacted genes

pathway name

pathway description

target genes enrich in pathway

p-value

hsa05215	Prostate cancer	ERBB2,IGF2,BCL2,RAF1,CREBBP,FGFR2,CCNE1,AKT1,E2F3,TP53,E2F2,	1.41E-5
hsa05200	Pathways in cancer	ERBB2,GLI1,BCL2,STAT3,RAF1,BAX,FGFR2,CDKN2A,ABL1,XIAP,AKT1,E2F3,TP53,E2F2,CEBPA,FZD4,SMO,CREBBP,ETS1,CCNE1,	4.16E-5
hsa04722	Neurotrophin signaling pathway	BCL2,MAPK14,RAF1,BAX,ABL1,SORT1,IRS4,AKT1,TP53,RPS6KA1,NTRK3,	2.45E-4
hsa05212	Pancreatic cancer	ERBB2,STAT3,RAF1,CDKN2A,AKT1,E2F3,TP53,E2F2,	7.17E-4
hsa05223	Non-small cell lung cancer	ERBB2,RAF1,CDKN2A,AKT1,E2F3,TP53,E2F2,	8.57E-4

hsa05219	Bladder cancer	ERBB2,RAF1,CDKN2A,E2F3,TP53,E2F2,	1.71E-2
hsa04910	Insulin signaling pathway	HK2,MKNK2,IGF2,PRKAG1,RAF1,PPP1CA,EIF4EBP1,EXOC7,IRS4,AKT1,	1.98E-2
hsa03010	Ribosome	RPS7,RPL3,RPS3A,RPS12,RPL35A,RPL29,RPLP0,RPS28,	2.19E-2
hsa05220	Chronic myeloid leukemia	RAF1,CDKN2A,ABL1,AKT1,E2F3,TP53,E2F2,	4.68E-2
hsa05222	Small cell lung cancer	BCL2,XIAP,CCNE1,AKT1,E2F3,TP53,E2F2,	8.12E-2
hsa05214	Glioma	RAF1,CDKN2A,AKT1,E2F3,TP53,E2F2,	1.00E-1
hsa05016	Huntington's disease	ATP5B,NDUFS7,COX7C,BBC3,SDHB,CREBBP,BAX,VDAC1,TP53,HTT,	1.29E-1
hsa04115	p53 signaling pathway	BBC3,BAX,CDKN2A,CCNE1,TP53,PMAIP1,	1.37E-1
hsa05218	Melanoma	RAF1,CDKN2A,AKT1,E2F3,TP53,E2F2,	1.62E-1
hsa04150	mTOR signaling pathway	IGF2,ULK3,EIF4EBP1,AKT1,RPS6KA1,	2.31E-1
hsa05014	Amyotrophic lateral sclerosis (ALS)	GRIN2A,BCL2,MAPK14,BAX,TP53,	2.46E-1
hsa05210	Colorectal cancer	FZD4,BCL2,RAF1,BAX,AKT1,TP53,	3.12E-1
hsa05221	Acute myeloid leukemia	CEBPA,STAT3,RAF1,EIF4EBP1,AKT1,	3.29E-1
hsa04012	ErbB signaling pathway	ERBB2,ERBB3,RAF1,EIF4EBP1,ABL1,AKT1,	3.55E-1
hsa04110	Cell cycle	CREBBP,CDKN2A,ABL1,CCNE1,E2F3,TP53,E2F2,	4.72E-1
hsa04720	Long-term potentiation	GRIN2A,RAF1,CREBBP,PPP1CA,RPS6KA1,	5.40E-1
hsa04930	Type II diabetes mellitus	HK2,IGF2,PKM2,IRS4,	7.54E-1
hsa05213	Endometrial cancer	ERBB2,RAF1,AKT1,TP53,	9.55E-1
hsa04950	Maturity onset diabetes of the young	HNF4G,IGF2,HNF4A,	9.62E-1

Gene ontology terms enriched for interacted genes

GO terms

GO terms description

target genes enrich in GO term

p-value

GO:0006357	regulation of transcription from RNA polymerase II promoter	THRAP3,IRF4,BCOR,CBFB,STAT3,MAPK14,MTF1,SP7,CEBPA,HNF4G,SUPT6H,SPEN,HNF4A,CRTC1,CEBPG,VDR,MTA2,CREBBP,CSRNP2,RYBP,ZMYND11,BCL3,PRDM1,STRN3,GLI1,ATXN1,HOXA13,ABL1,TP53,EHMT1,MED1,KLF13,LIF,SMARCD2,ETS1,TEF,	1.09E-7
GO:0008637	apoptotic mitochondrial changes	BCL2,BBC3,BAX,CDKN2A,BAK1,AKT1,TP53,PMAIP1,	1.06E-6
GO:0042981	regulation of apoptosis	CSTB,PRDX2,RPS3A,CDKN2A,PRKRA,XIAP,IGF2,CEBPG,BBC3,VDR,BAK1,BCL3,HSPA1B,ERBB2,GRIN2A,ERBB3,BCL2,EPHA7,NPM1,BAX,HOXA13,ABL1,SORT1,AKT1,TP53,BMF,PMAIP1,HSPD1,SMO,TP53INP1,NME2,TNFAIP3,ETS1,HTT,BCL2L13,	3.27E-6
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	THRAP3,IRF4,GLI1,STRN3,CBFB,STAT3,MAPK14,MTF1,ATXN1,HOXA13,TP53,MED1,KLF13,CEBPA,HNF4A,CRTC1,LIF,MTA2,CSRNP2,CREBBP,ETS1,BCL3,	3.94E-6
GO:0043067	regulation of programmed cell death	CSTB,PRDX2,RPS3A,CDKN2A,PRKRA,XIAP,IGF2,CEBPG,BBC3,VDR,BAK1,BCL3,HSPA1B,ERBB2,GRIN2A,ERBB3,BCL2,EPHA7,NPM1,BAX,HOXA13,ABL1,SORT1,AKT1,TP53,BMF,PMAIP1,HSPD1,SMO,TP53INP1,NME2,TNFAIP3,ETS1,HTT,BCL2L13,	4.06E-6

GO:0010941	regulation of cell death	CSTB,PRDX2,RPS3A,CDKN2A,PRKRA,XIAP,IGF2,CEBPG,BBC3,VDR,BAK1,BCL3,HSPA1B,ERBB2,GRIN2A,ERBB3,BCL2,EPHA7,NPM1,BAX,HOXA13,ABL1,SORT1,AKT1,TP53,BMF,PMAIP1,HSPD1,SMO,TP53INP1,NME2,TNFAIP3,ETS1,HTT,BCL2L13,	4.39E-6
GO:0045893	positive regulation of transcription, DNA-dependent	THRAP3,IRF4,CBFB,STAT3,MTF1,MAPK14,CEBPA,HNF4A,CRTC1,MTA2,CREBBP,CSRNP2,BCL3,GLI1,STRN3,ATXN1,HOXA13,HMGA1,TP53,E2F3,MED1,KLF13,LIF,ETS1,CCNE1,	6.13E-6
GO:0010608	posttranscriptional regulation of gene expression	BCL2,CASC3,CDKN2A,LIN28B,PRKRA,KRT7,AKT1,LIN28A,HSPD1,EIF5,MKNK2,EIF4EBP1,ETF1,TNRC6B,PABPC1,BCL3,	6.90E-6
GO:0051254	positive regulation of RNA metabolic process	THRAP3,IRF4,CBFB,STAT3,MTF1,MAPK14,CEBPA,HNF4A,CRTC1,MTA2,CREBBP,CSRNP2,BCL3,GLI1,STRN3,ATXN1,HOXA13,HMGA1,TP53,E2F3,MED1,KLF13,LIF,ETS1,CCNE1,	7.09E-6
GO:0007005	mitochondrion organization	BCL2,BAX,CDKN2A,AKT1,TP53,TIMM10,PMAIP1,CEBPA,NDUFS7,TIMM23,BBC3,BAK1,HTT,	7.71E-6
GO:0051252	regulation of RNA metabolic process	THRAP3,BACH1,STAT3,MTF1,ZNF212,LIN28B,ASH2L,CEBPA,IGF2,SUPT6H,CRTC1,CEBPG,CREBBP,ESRP2,BCL3,PRDM1,ZNF395,ATXN1,HOXA13,ABL1,EHMT1,KLF13,NME2,SMARCD2,ETS1,LBX2,PABPC1,IRF4,BCOR,CBFB,MAPK14,SP7,CDKN2A,HMGA2,LIN28A,HNF4G,SPEN,HNF4A,E2F7,MTA2,VDR,CSRNP2,RYBP,CARHSP1,ZMYND11,GLI1,STRN3,NPM1,HMGA1,E2F3,TP53,E2F2,MED1,MLL2,LIF,HKR1,CCNE1,ZNF483,TEF,	7.84E-6
GO:0043065	positive regulation of apoptosis	GRIN2A,BCL2,EPHA7,BAX,HOXA13,CDKN2A,RPS3A,ABL1,PRKRA,SORT1,AKT1,TP53,PMAIP1,HSPD1,TP53INP1,CEBPG,BBC3,VDR,ETS1,BAK1,HTT,BCL3,BCL2L13,	1.16E-5
GO:0043068	positive regulation of programmed cell death	GRIN2A,BCL2,EPHA7,BAX,HOXA13,CDKN2A,RPS3A,ABL1,PRKRA,SORT1,AKT1,TP53,PMAIP1,HSPD1,TP53INP1,CEBPG,BBC3,VDR,ETS1,BAK1,HTT,BCL3,BCL2L13,	1.30E-5
GO:0010942	positive regulation of cell death	GRIN2A,BCL2,EPHA7,BAX,HOXA13,CDKN2A,RPS3A,ABL1,PRKRA,SORT1,AKT1,TP53,PMAIP1,HSPD1,TP53INP1,CEBPG,BBC3,VDR,ETS1,BAK1,HTT,BCL3,BCL2L13,	1.40E-5
GO:0051173	positive regulation of nitrogen compound metabolic process	THRAP3,IRF4,CBFB,STAT3,MAPK14,MTF1,CEBPA,IGF2,HNF4A,CEBPG,CRTC1,MTA2,CREBBP,CSRNP2,USP22,BCL3,STRN3,GLI1,ATXN1,HOXA13,HMGA1,AKT1,E2F3,TP53,MED1,KLF13,LIF,ETS1,CCNE1,	1.58E-5
GO:0031328	positive regulation of cellular biosynthetic process	THRAP3,IRF4,CBFB,STAT3,MAPK14,MTF1,CEBPA,IGF2,HNF4A,CEBPG,CRTC1,MTA2,CREBBP,CSRNP2,USP22,BCL3,STRN3,GLI1,NPM1,ATXN1,HOXA13,HMGA1,AKT1,E2F3,TP53,MED1,KLF13,LIF,ETS1,CCNE1,	1.81E-5
GO:0010628	positive regulation of gene expression	THRAP3,IRF4,CBFB,STAT3,MAPK14,MTF1,CEBPA,HNF4A,CRTC1,MTA2,CREBBP,CSRNP2,USP22,BCL3,PRDM1,STRN3,GLI1,ATXN1,HOXA13,HMGA1,TP53,E2F3,MED1,KLF13,LIF,ETS1,CCNE1,	1.97E-5
GO:0010557	positive regulation of macromolecule biosynthetic process	THRAP3,IRF4,CBFB,STAT3,MAPK14,MTF1,CEBPA,IGF2,HNF4A,CEBPG,CRTC1,MTA2,CREBBP,CSRNP2,USP22,BCL3,STRN3,GLI1,ATXN1,HOXA13,HMGA1,AKT1,E2F3,TP53,MED1,KLF13,LIF,ETS1,CCNE1,	2.09E-5
GO:0009891	positive regulation of biosynthetic process	THRAP3,IRF4,CBFB,STAT3,MAPK14,MTF1,CEBPA,IGF2,HNF4A,CEBPG,CRTC1,MTA2,CREBBP,CSRNP2,USP22,BCL3,STRN3,GLI1,NPM1,ATXN1,HOXA13,HMGA1,AKT1,E2F3,TP53,MED1,KLF13,LIF,ETS1,CCNE1,	2.40E-5
GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	THRAP3,IRF4,CBFB,STAT3,MAPK14,MTF1,CEBPA,IGF2,HNF4A,CEBPG,CRTC1,MTA2,CREBBP,CSRNP2,USP22,BCL3,STRN3,GLI1,ATXN1,HOXA13,HMGA1,E2F3,TP53,MED1,KLF13,LIF,ETS1,CCNE1,	2.45E-5
GO:0052547	regulation of peptidase activity	CSTB,BBC3,BAX,CDKN2A,BAK1,NRD1,TP53,BCL2L13,HSPD1,PMAIP1,	2.47E-5
GO:0001836	release of cytochrome c from mitochondria	BCL2,BBC3,BAX,BAK1,TP53,PMAIP1,	3.00E-5
GO:0046902	regulation of mitochondrial membrane permeability	BCL2,BAX,BAK1,TP53,HTT,	3.13E-5
GO:0045941	positive regulation of transcription	THRAP3,IRF4,CBFB,STAT3,MAPK14,MTF1,CEBPA,HNF4A,CRTC1,MTA2,CREBBP,CSRNP2,USP22,BCL3,GLI1,STRN3,ATXN1,HOXA13,HMGA1,TP53,E2F3,MED1,KLF13,LIF,ETS1,CCNE1,	3.36E-5
GO:0006355	regulation of transcription, DNA-dependent	THRAP3,BACH1,STAT3,MTF1,ZNF212,LIN28B,ASH2L,CEBPA,IGF2,SUPT6H,CRTC1,CEBPG,CREBBP,BCL3,PRDM1,ZNF395,ATXN1,HOXA13,ABL1,EHMT1,KLF13,NME2,SMARCD2,ETS1,LBX2,IRF4,BCOR,CBFB,MAPK14,SP7,CDKN2A,HMGA2,LIN28A,HNF4G,SPEN,HNF4A,E2F7,MTA2,VDR,CSRNP2,RYBP,CARHSP1,ZMYND11,GLI1,STRN3,HMGA1,E2F3,TP53,E2F2,MED1,MLL2,LIF,HKR1,CCNE1,ZNF483,TEF,	3.49E-5
GO:0008219	cell death	RAF1,CDKN2A,VDAC1,XIAP,IGF2,BBC3,CSRNP2,RYBP,SGPL1,BAK1,FUS,ERBB3,BCL2,BAX,ATXN1,NDOR1,AKT1,FXR1,TP53,E2F2,BMF,HSPD1,LUC7L3,PMAIP1,TP53INP1,TARDBP,TNFAIP3,PKM2,HTT,BCL2L13,	4.37E-5
GO:0016265	death	RAF1,CDKN2A,VDAC1,XIAP,IGF2,BBC3,CSRNP2,RYBP,SGPL1,BAK1,FUS,ERBB3,BCL2,BAX,ATXN1,NDOR1,AKT1,FXR1,TP53,E2F2,BMF,HSPD1,LUC7L3,PMAIP1,TP53INP1,TARDBP,TNFAIP3,PKM2,HTT,BCL2L13,	4.90E-5
GO:0006919	activation of caspase activity	BBC3,BAX,CDKN2A,BAK1,TP53,BCL2L13,HSPD1,PMAIP1,	5.02E-5
GO:0010604	positive regulation of macromolecule metabolic process	THRAP3,IRF4,CBFB,STAT3,MAPK14,MTF1,NRD1,CEBPA,IGF2,HNF4A,CRTC1,CEBPG,MTA2,CREBBP,CSRNP2,USP22,BCL3,PRDM1,STRN3,GLI1,BCL2,ATXN1,HOXA13,HMGA1,AKT1,E2F3,TP53,MED1,KLF13,PSMB1,LIF,ETS1,CCNE1,	7.63E-5
GO:0010952	positive regulation of peptidase activity	BBC3,BAX,CDKN2A,BAK1,TP53,BCL2L13,HSPD1,PMAIP1,	8.97E-5
GO:0043280	positive regulation of caspase activity	BBC3,BAX,CDKN2A,BAK1,TP53,BCL2L13,HSPD1,PMAIP1,	8.97E-5
GO:0051098	regulation of binding	IRF4,HNF4A,BCL2,SMO,CEBPG,PRDX2,NPM1,NME2,BAX,CDKN2A,BAK1,BCL3,	1.06E-4
GO:0052548	regulation of endopeptidase activity	BBC3,BAX,CDKN2A,BAK1,NRD1,TP53,BCL2L13,HSPD1,PMAIP1,	1.15E-4
GO:0006401	RNA catabolic process	HSPA1B,CASC3,RNASEH2A,LIN28B,RNH1,PABPC4,SMG1,LIN28A,	1.66E-4
GO:0006917	induction of apoptosis	BAX,CDKN2A,RPS3A,ABL1,PRKRA,SORT1,TP53,PMAIP1,TP53INP1,BBC3,CEBPG,VDR,ETS1,BAK1,BCL3,BCL2L13,HTT,	2.42E-4
GO:0006839	mitochondrial transport	TIMM23,BCL2,BAX,BAK1,TIMM10,SLC25A1,TP53,HTT,	2.43E-4
GO:0043066	negative regulation of apoptosis	HSPA1B,ERBB2,ERBB3,BCL2,NPM1,PRDX2,BAX,XIAP,SORT1,AKT1,TP53,HSPD1,IGF2,SMO,NME2,TNFAIP3,HTT,BCL3,	2.51E-4
GO:0012502	induction of programmed cell death	BAX,CDKN2A,RPS3A,ABL1,PRKRA,SORT1,TP53,PMAIP1,TP53INP1,BBC3,CEBPG,VDR,ETS1,BAK1,BCL3,BCL2L13,HTT,	2.51E-4
GO:0007006	mitochondrial membrane organization	BCL2,BAX,BAK1,TIMM10,TP53,HTT,	2.52E-4
GO:0006351	transcription, DNA-dependent	THRAP3,CBFB,CDKN2A,ASH2L,TP53,E2F3,E2F2,MED1,KLF13,CEBPA,HNF4G,TARDBP,MYEF2,ETS1,ADRM1,PARP1,	2.85E-4
GO:0043069	negative regulation of programmed cell death	HSPA1B,ERBB2,ERBB3,BCL2,NPM1,PRDX2,BAX,XIAP,SORT1,AKT1,TP53,HSPD1,IGF2,SMO,NME2,TNFAIP3,HTT,BCL3,	2.92E-4
GO:0012501	programmed cell death	RAF1,CDKN2A,VDAC1,XIAP,BBC3,CSRNP2,RYBP,SGPL1,BAK1,ERBB3,BCL2,BAX,AKT1,FXR1,TP53,LUC7L3,HSPD1,PMAIP1,BMF,E2F2,TP53INP1,TNFAIP3,PKM2,BCL2L13,HTT,	3.05E-4
GO:0060548	negative regulation of cell death	HSPA1B,ERBB2,ERBB3,BCL2,NPM1,PRDX2,BAX,XIAP,SORT1,AKT1,TP53,HSPD1,IGF2,SMO,NME2,TNFAIP3,HTT,BCL3,	3.07E-4
GO:0032774	RNA biosynthetic process	THRAP3,CBFB,CDKN2A,ASH2L,TP53,E2F3,E2F2,MED1,KLF13,CEBPA,HNF4G,TARDBP,MYEF2,ETS1,ADRM1,PARP1,	3.30E-4
GO:0006366	transcription from RNA polymerase II promoter	THRAP3,CBFB,ASH2L,E2F3,E2F2,MED1,CEBPA,KLF13,HNF4G,TARDBP,MYEF2,ETS1,ADRM1,PARP1,	3.42E-4
GO:0006396	RNA processing	SRRM2,SNRPB,KHSRP,CASC3,ATXN1,CDKN2A,LIN28B,PABPC4,PCBP2,RPL35A,PRKRA,NSUN2,LIN28A,LUC7L3,RPS28,RPS7,TARDBP,SUGP2,ESRP2,HNRNPK,DHX38,FUS,PABPC1,	3.96E-4
GO:0006414	translational elongation	RPS7,RPL3,RPS3A,RPS12,EEF1A1,RPL35A,RPL29,RPLP0,RPS28,	4.89E-4
GO:0002520	immune system development	IRF4,BCL2,CBFB,PRDX2,BAX,ASH2L,TP53,HSPD1,MED1,CEBPA,CEBPG,UNG,SGPL1,BAK1,BCL3,	5.13E-4
GO:0043281	regulation of caspase activity	BBC3,BAX,CDKN2A,BAK1,TP53,BCL2L13,HSPD1,PMAIP1,	5.61E-4
GO:0006915	apoptosis	ERBB3,BCL2,RAF1,BAX,CDKN2A,VDAC1,XIAP,AKT1,FXR1,TP53,E2F2,BMF,PMAIP1,LUC7L3,HSPD1,TP53INP1,BBC3,CSRNP2,TNFAIP3,RYBP,SGPL1,BAK1,HTT,BCL2L13,	6.02E-4
GO:0016310	phosphorylation	SIK2,MAPK14,RAF1,IP6K1,PRDX2,ULK3,ND6,PRKRA,BCKDK,NDUFS7,MKNK2,HK2,ATP5B,ERBB2,ERBB3,BCL2,BMPR1B,EPHA7,FGFR2,ABL1,AKT1,WNK1,AURKB,PRKAG1,NME2,SMG1,MAP3K2,RPS6KA1,NTRK3,	6.23E-4
GO:0001501	skeletal system development	BCL2,BMPR1B,GLI1,CBFB,MAPK14,SP7,HOXA13,PRKRA,SORT1,CYP24A1,IGF2,SMO,VDR,SGPL1,MMP13,FBN1,	7.11E-4
GO:0006796	phosphate metabolic process	SIK2,MAPK14,RAF1,IP6K1,PRDX2,ULK3,ND6,PRKRA,BCKDK,NDUFS7,MKNK2,MTMR3,HK2,ATP5B,ERBB2,ERBB3,BCL2,BMPR1B,EPHA7,MTMR12,FGFR2,ABL1,AKT1,WNK1,AURKB,PRKAG1,NME2,PPP1CA,MTMR4,SMG1,MAP3K2,RPS6KA1,NTRK3,	7.36E-4
GO:0006793	phosphorus metabolic process	SIK2,MAPK14,RAF1,IP6K1,PRDX2,ULK3,ND6,PRKRA,BCKDK,NDUFS7,MKNK2,MTMR3,HK2,ATP5B,ERBB2,ERBB3,BCL2,BMPR1B,EPHA7,MTMR12,FGFR2,ABL1,AKT1,WNK1,AURKB,PRKAG1,NME2,PPP1CA,MTMR4,SMG1,MAP3K2,RPS6KA1,NTRK3,	7.36E-4
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	ERBB2,ERBB3,STAT3,SIK2,EPHA7,RAF1,FGFR2,SORT1,AKT1,IGF2,EIF4EBP1,SGPL1,NTRK3,	7.93E-4
GO:0010605	negative regulation of macromolecule metabolic process	BCOR,STAT3,CDKN2A,LIN28B,PRKRA,LIN28A,CEBPA,SPEN,IGF2,HNF4A,VDR,MTA2,RYBP,EIF4EBP1,BAK1,TNRC6B,ZMYND11,BCL3,GRIN2A,PRDM1,STRN3,NPM1,BAX,ATXN1,TP53,EHMT1,PSMB1,	8.10E-4
GO:0051881	regulation of mitochondrial membrane potential	BCL2,BAX,BAK1,HTT,	8.69E-4
GO:0001649	osteoblast differentiation	IGF2,CYP24A1,GLI1,SMO,CBFB,SP7,	9.20E-4
GO:0001503	ossification	IGF2,CYP24A1,GLI1,BCL2,SMO,CBFB,SP7,SORT1,MMP13,	1.15E-2
GO:0016071	mRNA metabolic process	SRRM2,HSPA1B,SNRPB,KHSRP,CASC3,PCBP2,LUC7L3,CEBPG,TARDBP,RNH1,SUGP2,ESRP2,HNRNPK,DHX38,SMG1,FUS,PABPC1,	1.17E-2
GO:0010033	response to organic substance	ADM,STAT3,SIK2,MAPK14,PRDX2,LIN28B,PRKRA,LIN28A,EDEM1,IGF2,HNF4A,EIF4EBP1,HSPA1B,ERBB2,GRIN2A,ERBB3,BCL2,STRN3,SORT1,AKT1,HSPD1,PMAIP1,NME2,MMP13,CCNE1,PARP1,	1.39E-2
GO:0051101	regulation of DNA binding	IRF4,HNF4A,SMO,CEBPG,PRDX2,NPM1,NME2,CDKN2A,BCL3,	1.60E-2
GO:0030183	B cell differentiation	BCL2,CEBPG,BAX,BAK1,TP53,BCL3,	1.69E-2
GO:0060348	bone development	IGF2,CYP24A1,GLI1,BCL2,SMO,CBFB,SP7,SORT1,MMP13,	1.77E-2
GO:0033135	regulation of peptidyl-serine phosphorylation	BCL2,LIF,BAX,BAK1,	1.84E-2
GO:0050657	nucleic acid transport	NUP93,NPM1,KHSRP,CASC3,SMG1,NUP205,TMEM48,RANBP2,	1.88E-2
GO:0051236	establishment of RNA localization	NUP93,NPM1,KHSRP,CASC3,SMG1,NUP205,TMEM48,RANBP2,	1.88E-2
GO:0050658	RNA transport	NUP93,NPM1,KHSRP,CASC3,SMG1,NUP205,TMEM48,RANBP2,	1.88E-2
GO:0043497	regulation of protein heterodimerization activity	BCL2,BAX,BAK1,	1.91E-2
GO:0043434	response to peptide hormone stimulus	IGF2,BCL2,ERBB3,ADM,SIK2,STAT3,EIF4EBP1,SORT1,AKT1,PARP1,	1.96E-2
GO:0006913	nucleocytoplasmic transport	KPNB1,NPM1,ATXN1,SMG1,AKT1,NUP205,TP53,HTT,BCL3,RANBP2,	2.14E-2
GO:0006403	RNA localization	NUP93,NPM1,KHSRP,CASC3,SMG1,NUP205,TMEM48,RANBP2,	2.24E-2
GO:0032868	response to insulin stimulus	IGF2,ERBB3,ADM,SIK2,EIF4EBP1,SORT1,AKT1,PARP1,	2.24E-2
GO:0044093	positive regulation of molecular function	IRF4,ERBB2,BCL2,NPM1,PRDX2,BAX,CDKN2A,ABL1,AKT1,TP53,PMAIP1,HSPD1,PSMB1,IGF2,PRKAG1,CEBPG,BBC3,VDR,NME2,BAK1,MAP3K2,BCL2L13,	2.27E-2
GO:0051169	nuclear transport	KPNB1,NPM1,ATXN1,SMG1,AKT1,NUP205,TP53,HTT,BCL3,RANBP2,	2.34E-2
GO:0042113	B cell activation	BCL2,CEBPG,BAX,BAK1,TP53,BCL3,HSPD1,	2.52E-2
GO:0032268	regulation of cellular protein metabolic process	BCL2,BAX,CASC3,CDKN2A,KRT7,NRD1,AKT1,EIF5,MKNK2,PSMB1,IGF2,HNF4A,LIF,EIF4EBP1,BAK1,ETF1,MAP3K2,TNRC6B,BCL3,	2.54E-2
GO:0002521	leukocyte differentiation	IRF4,CEBPA,BCL2,CBFB,CEBPG,BAX,BAK1,TP53,BCL3,	2.63E-2
GO:0017038	protein import	TIMM23,KPNB1,AKT1,TIMM10,NUP205,TP53,HTT,BCL3,RANBP2,	2.63E-2
GO:0022411	cellular component disassembly	MTRF1L,BAX,CDKN2A,HMGA1,ETF1,PMAIP1,	2.64E-2
GO:0048534	hemopoietic or lymphoid organ development	IRF4,BCL2,CBFB,PRDX2,BAX,ASH2L,TP53,MED1,CEBPA,CEBPG,SGPL1,BAK1,BCL3,	2.81E-2
GO:0007569	cell aging	BCL2,NPM1,CDKN2A,TP53,HTT,	2.84E-2
GO:0006412	translation	MTRF1L,RPL3,RPS3A,EEF1A1,RPS12,PABPC4,RPL35A,RPL29,RPLP0,RPS28,EIF5,RPS7,HBS1L,ABTB1,ETF1,	2.89E-2
GO:0051726	regulation of cell cycle	BCL2,MAPK14,NPM1,BAX,HOXA13,CDKN2A,AKT1,TP53,E2F2,IGF2,HNF4A,LIF,USP22,ETS1,BAK1,	2.89E-2
GO:0045597	positive regulation of cell differentiation	IGF2,BCL2,SMO,BMPR1B,LIF,MAPK14,NME2,NPTN,ETS1,CCNE1,AKT1,NTRK3,	3.06E-2
GO:0070059	apoptosis in response to endoplasmic reticulum stress	BCL2,BAX,BAK1,	3.15E-2
GO:0046649	lymphocyte activation	IRF4,IGF2,BCL2,CBFB,CEBPG,PRDX2,BAX,BAK1,TP53,BCL3,HSPD1,	3.39E-2
GO:0006417	regulation of translation	MKNK2,EIF5,CASC3,EIF4EBP1,KRT7,ETF1,AKT1,TNRC6B,BCL3,	3.47E-2
GO:0009314	response to radiation	GRIN2A,BCL2,BAX,ATXN1,CNGB1,BAK1,AKT1,TP53,HTT,BCL3,NES,	3.52E-2
GO:0009416	response to light stimulus	GRIN2A,BCL2,BAX,ATXN1,CNGB1,AKT1,TP53,HTT,BCL3,	3.63E-2
GO:0007167	enzyme linked receptor protein signaling pathway	ERBB2,ERBB3,BMPR1B,STAT3,SIK2,EPHA7,RAF1,FGFR2,SORT1,AKT1,IGF2,LIF,EIF4EBP1,SGPL1,NTRK3,	3.84E-2
GO:0030097	hemopoiesis	IRF4,CEBPA,BCL2,CBFB,CEBPG,BAX,ASH2L,SGPL1,BAK1,TP53,MED1,BCL3,	3.85E-2
GO:0015931	nucleobase, nucleoside, nucleotide and nucleic acid transport	NUP93,NPM1,KHSRP,CASC3,SMG1,NUP205,TMEM48,RANBP2,	4.45E-2
GO:0001890	placenta development	CEBPA,PRDM1,LIF,VDR,AKT1,MED1,	4.54E-2
GO:0051402	neuron apoptosis	BCL2,ERBB3,BAX,HTT,	4.58E-2
GO:0006606	protein import into nucleus	KPNB1,AKT1,NUP205,TP53,HTT,BCL3,RANBP2,	4.66E-2
GO:0045449	regulation of transcription	THRAP3,STAT3,BACH1,MTF1,KHSRP,ZNF212,LIN28B,ASH2L,CEBPA,IGF2,SUPT6H,CRTC1,CEBPG,CREBBP,BCL3,PRDM1,PTOV1,ZNF395,ATXN1,HOXA13,ABL1,EHMT1,KLF13,NME2,SMARCD2,ETS1,LBX2,ARID3B,ZNF592,IRF4,BCOR,CBFB,MAPK14,PRDX2,SP7,CDKN2A,HMGA2,LIN28A,HNF4G,SPEN,HNF4A,E2F7,MTA2,VDR,CSRNP2,RYBP,USP22,CARHSP1,ZMYND11,GLI1,STRN3,NPM1,HMGA1,E2F3,TP53,E2F2,MED1,MLL2,LIF,TARDBP,HKR1,HDGF,CCNE1,ZNF483,TEF,	4.70E-2
GO:0010629	negative regulation of gene expression	PRDM1,BCOR,STRN3,STAT3,BAX,ATXN1,LIN28B,PRKRA,TP53,LIN28A,EHMT1,CEBPA,SPEN,MTA2,VDR,RYBP,TNRC6B,ZMYND11,BCL3,	4.77E-2
GO:0051094	positive regulation of developmental process	BCL2,BMPR1B,MAPK14,NPTN,BAX,AKT1,IGF2,SMO,LIF,NME2,ETS1,CCNE1,NTRK3,	4.80E-2
GO:0006468	protein amino acid phosphorylation	ERBB2,ERBB3,BMPR1B,BCL2,SIK2,MAPK14,EPHA7,RAF1,PRDX2,ULK3,FGFR2,ABL1,PRKRA,BCKDK,AKT1,WNK1,MKNK2,AURKB,PRKAG1,SMG1,MAP3K2,RPS6KA1,NTRK3,	4.83E-2
GO:0070271	protein complex biogenesis	THRAP3,KPNB1,NPM1,BAX,SLC9A3R2,HMGA1,E2F3,NUP205,TP53,E2F2,HSPD1,MED1,NDUFS7,SLC7A6,PRKAG1,SHMT1,CREBBP,ADRM1,TMEM48,	4.87E-2
GO:0006461	protein complex assembly	THRAP3,KPNB1,NPM1,BAX,SLC9A3R2,HMGA1,E2F3,NUP205,TP53,E2F2,HSPD1,MED1,NDUFS7,SLC7A6,PRKAG1,SHMT1,CREBBP,ADRM1,TMEM48,	4.87E-2
GO:0051028	mRNA transport	NUP93,KHSRP,CASC3,SMG1,NUP205,TMEM48,RANBP2,	4.93E-2
GO:0043933	macromolecular complex subunit organization	THRAP3,DGAT1,MTRF1L,SNRPB,KPNB1,NPM1,BAX,SLC9A3R2,HMGA1,E2F3,NUP205,TP53,E2F2,HSPD1,MED1,NDUFS7,SLC7A6,PRKAG1,SHMT1,HIST2H2BF,CREBBP,ETF1,ADRM1,TMEM48,	4.98E-2
GO:0033365	protein localization in organelle	TIMM23,KPNB1,AKT1,TIMM10,NUP205,TP53,HTT,BCL3,RANBP2,	5.10E-2
GO:0051170	nuclear import	KPNB1,AKT1,NUP205,TP53,HTT,BCL3,RANBP2,	5.22E-2
GO:0008380	RNA splicing	SRRM2,SNRPB,KHSRP,CASC3,PCBP2,LUC7L3,TARDBP,HNRNPK,ESRP2,SUGP2,DHX38,FUS,PABPC1,	5.72E-2
GO:0008285	negative regulation of cell proliferation	ERBB2,ADM,BCL2,NPM1,PTGES,BAX,CDKN2A,PRKRA,TP53,CEBPA,HNF4A,E2F7,VDR,NME2,ETS1,	6.18E-2
GO:0043496	regulation of protein homodimerization activity	BCL2,BAX,BAK1,	6.46E-2
GO:0043085	positive regulation of catalytic activity	ERBB2,BCL2,NPM1,PRDX2,BAX,CDKN2A,ABL1,AKT1,TP53,HSPD1,PMAIP1,PSMB1,IGF2,PRKAG1,BBC3,VDR,BAK1,MAP3K2,BCL2L13,	6.59E-2
GO:0006350	transcription	THRAP3,BACH1,STAT3,MTF1,KHSRP,ZNF212,ASH2L,CEBPA,SUPT6H,CRTC1,CEBPG,CREBBP,BCL3,PRDM1,PTOV1,ZNF395,HOXA13,KLF13,NME2,SMARCD2,ETS1,ARID3B,LBX2,ZNF592,ADRM1,IRF4,BCOR,CBFB,SP7,CDKN2A,HMGA2,HNF4G,SPEN,HNF4A,E2F7,VDR,CSRNP2,RYBP,USP22,ZMYND11,GLI1,HMGA1,E2F3,TP53,E2F2,MED1,MLL2,TARDBP,HKR1,MYEF2,HDGF,ZNF483,TEF,PARP1,	6.59E-2
GO:0046651	lymphocyte proliferation	BCL2,PRDX2,BAX,TP53,HSPD1,	6.85E-2
GO:0034504	protein localization in nucleus	KPNB1,AKT1,NUP205,TP53,HTT,BCL3,RANBP2,	7.17E-2
GO:0010551	regulation of specific transcription from RNA polymerase II promoter	IRF4,CEBPA,HNF4A,BCOR,VDR,ETS1,TP53,	7.17E-2
GO:0051276	chromosome organization	IRF4,BCOR,NPM1,SMC2,HMGA2,HMGA1,TP53,EHMT1,MLL2,HUWE1,TNKS1BP1,SUPT6H,HIST2H2BF,MTA2,CREBBP,USP22,SMARCD2,PARP1,	7.23E-2
GO:0032869	cellular response to insulin stimulus	IGF2,ERBB3,SIK2,EIF4EBP1,AKT1,PARP1,	7.71E-2
GO:0010332	response to gamma radiation	BCL2,BAX,BAK1,TP53,	7.95E-2
GO:0042110	T cell activation	IRF4,IGF2,BCL2,PRDX2,BAX,TP53,BCL3,HSPD1,	8.00E-2
GO:0032943	mononuclear cell proliferation	BCL2,PRDX2,BAX,TP53,HSPD1,	8.07E-2
GO:0070661	leukocyte proliferation	BCL2,PRDX2,BAX,TP53,HSPD1,	8.07E-2
GO:0070727	cellular macromolecule localization	KPNB1,NPM1,BAX,CASC3,SORT1,AKT1,TP53,TIMM10,NUP205,RANBP2,AURKB,TIMM23,SSR3,HTT,BCL3,SEC24A,	8.49E-2
GO:0032469	endoplasmic reticulum calcium ion homeostasis	BCL2,BAX,BAK1,	8.51E-2
GO:0031670	cellular response to nutrient	CYP24A1,VDR,CCNE1,	8.51E-2
GO:0048511	rhythmic process	ERBB2,GRIN2A,BCL2,ERBB3,BMPR1B,BAX,CCNE1,TEF,	8.69E-2
GO:0042326	negative regulation of phosphorylation	HNF4A,BAX,ATXN1,CDKN2A,BAK1,	8.74E-2
GO:0035107	appendage morphogenesis	BMPR1B,BAX,HOXA13,BAK1,DYNC2H1,MMP13,MED1,	9.17E-2
GO:0035108	limb morphogenesis	BMPR1B,BAX,HOXA13,BAK1,DYNC2H1,MMP13,MED1,	9.17E-2
GO:0040008	regulation of growth	BCL2,STAT3,CDKN2A,HMGA2,AKT1,TP53,IGF2,HNF4A,BBC3,CD320,SGPL1,PARP1,NTRK3,EXTL3,	9.37E-2
GO:0065003	macromolecular complex assembly	THRAP3,DGAT1,SNRPB,KPNB1,NPM1,BAX,SLC9A3R2,HMGA1,E2F3,NUP205,TP53,E2F2,HSPD1,MED1,NDUFS7,SLC7A6,PRKAG1,SHMT1,HIST2H2BF,CREBBP,ADRM1,TMEM48,	9.43E-2
GO:0031667	response to nutrient levels	CYP24A1,BCL2,ADM,VDR,MUC1,STC2,CCNE1,AKT1,TP53,NES,	9.74E-2
GO:0043331	response to dsRNA	LIN28B,PRKRA,LIN28A,PMAIP1,	1.00E-1

KEGG pathways and Gene Ontology terms enriched for the interacted genes of ncRNA from RAID and miRTarBase.

disease name	related genes	p-value