ncRNADetailInformation

Detail Information
Functional analysis

miRNA name

pre-miRNA

family

pre-miRNA Sequence

mature-miRNA

mature sequence

pre-miRNA description

let-7d

MI0000065	MIPF0000002	CCUAGGAAGAGGUAGUAGGUUGCAUAGUUUUAGGGCAGGGAUUUUGCCCACAAGGAGGUAACUAUACGACCUGCUGCCUUUCUUAGG	MIMAT0000065 hsa-let-7d-5p	AGAGGUAGUAGGUUGCAUAGUU	The mature sequence shown here represents the most commonly cloned formfrom large-scale cloning studies .
MI0000065	MIPF0000002	CCUAGGAAGAGGUAGUAGGUUGCAUAGUUUUAGGGCAGGGAUUUUGCCCACAAGGAGGUAACUAUACGACCUGCUGCCUUUCUUAGG	MIMAT0004484 hsa-let-7d-3p	CUAUACGACCUGCUGCCUUUCU	The mature sequence shown here represents the most commonly cloned formfrom large-scale cloning studies .
MI0000065	MIPF0000002	CCUAGGAAGAGGUAGUAGGUUGCAUAGUUUUAGGGCAGGGAUUUUGCCCACAAGGAGGUAACUAUACGACCUGCUGCCUUUCUUAGG	MIMAT0000065 hsa-let-7d-5p	AGAGGUAGUAGGUUGCAUAGUU	The mature sequence shown here represents the most commonly cloned formfrom large-scale cloning studies .
MI0000065	MIPF0000002	CCUAGGAAGAGGUAGUAGGUUGCAUAGUUUUAGGGCAGGGAUUUUGCCCACAAGGAGGUAACUAUACGACCUGCUGCCUUUCUUAGG	MIMAT0004484 hsa-let-7d-3p	CUAUACGACCUGCUGCCUUUCU	The mature sequence shown here represents the most commonly cloned formfrom large-scale cloning studies .
MI0000065	MIPF0000002	CCUAGGAAGAGGUAGUAGGUUGCAUAGUUUUAGGGCAGGGAUUUUGCCCACAAGGAGGUAACUAUACGACCUGCUGCCUUUCUUAGG	MIMAT0000065 hsa-let-7d-5p	AGAGGUAGUAGGUUGCAUAGUU	The mature sequence shown here represents the most commonly cloned formfrom large-scale cloning studies .
MI0000065	MIPF0000002	CCUAGGAAGAGGUAGUAGGUUGCAUAGUUUUAGGGCAGGGAUUUUGCCCACAAGGAGGUAACUAUACGACCUGCUGCCUUUCUUAGG	MIMAT0000065 hsa-let-7d-5p	AGAGGUAGUAGGUUGCAUAGUU	The mature sequence shown here represents the most commonly cloned formfrom large-scale cloning studies .
MI0000065	MIPF0000002	CCUAGGAAGAGGUAGUAGGUUGCAUAGUUUUAGGGCAGGGAUUUUGCCCACAAGGAGGUAACUAUACGACCUGCUGCCUUUCUUAGG	MIMAT0000065 hsa-let-7d-5p	AGAGGUAGUAGGUUGCAUAGUU	The mature sequence shown here represents the most commonly cloned formfrom large-scale cloning studies .

link to database

TargetScanS 6.2 | MicroCosm | microRNA.org | miRNAMap 2.0

Interacted genes from RAID,miRTarBase

IL13,KRASP1,POLR2D,HMGA2,RPL31,GLMN,SLC30A6,SENP5,HOMER1,SMARCAD1,SLC35A4,THBS1,MYC,LIN52,ABT1
more » IL13,KRASP1,POLR2D,HMGA2,RPL31,GLMN,SLC30A6,SENP5,HOMER1,SMARCAD1,SLC35A4,THBS1,MYC,LIN52,ABT1,ZNF644,ZNF763,ESPL1,RPUSD2,RALGAPB,ZNF526,GOLT1B,GPR63,SOCS1,TGFBR1,TMTC3,OPRM1,ONECUT2,APP,CCND1,TMEM194A,C11orf57,ARID3A,FAM135A,PCGF3,NCOA1,SREK1IP1,IGDCC4,TPD52L2,TMED4,DLC1,SLC20A1,IGF2BP3,RBM12,IGF2BP1,FAS,LIN28B,SOLH,DHX57,H2AFX,LARP4B,IL6,DICER1,SPATA2,CACNG8,BUB3,ZBTB24,TOMM20,SMCR7L,AKAP8,MRPL51,HAND1,ISL1,TST,PDCD4,BACH1,ARRDC4,TMEM135,STK40,CPNE1,DRD3,USP24,DSC3,ZNF746,PDGFA,SPRYD4,LBR,C12orf4,TLE4,ZNF200,RPS6,ADCY9,ZNF354B,ERC1,PBX3,LIN28A,CALCOCO2,CDC34,KPNA5,TMEM2,SREK1,SLC12A2,CBR4,CEP120,CIZ1,GPR137B,FBXO3,UTP6,ZNF280B,PCNP,PRR13,KATNAL1,IGF1R,GCFC1,KRAS,CTDP1,TRIM71,RAD9A,NHLRC3,TBC1D9B,C9orf41,BIN3,FAM104A,MLL,SLC11A2,CASP3,SLC10A7,LRRC42,ZBTB39,TNRC6A,RFX5,NAA20,MPL

KEGG pathways enriched for interacted genes

pathway name

pathway description

target genes enrich in pathway

p-value

hsa05210	Colorectal cancer	CCND1,IGF1R,KRAS,TGFBR1,CASP3,MYC,	9.48E-5
hsa05200	Pathways in cancer	CCND1,IGF1R,FAS,PDGFA,KRAS,TGFBR1,IL6,CASP3,MYC,	3.56E-4
hsa04010	MAPK signaling pathway	FAS,PDGFA,NR4A1,KRAS,CACNG8,TGFBR1,CASP3,MYC,	5.85E-4
hsa04630	Jak-STAT signaling pathway	CCND1,IL13,MPL,SOCS1,IL6,MYC,	1.61E-2
hsa05219	Bladder cancer	CCND1,KRAS,MYC,THBS1,	1.64E-2

hsa05214	Glioma	CCND1,IGF1R,PDGFA,KRAS,	5.26E-2
hsa04115	p53 signaling pathway	CCND1,FAS,CASP3,THBS1,	6.51E-2
hsa05218	Melanoma	CCND1,IGF1R,PDGFA,KRAS,	7.34E-2
hsa05220	Chronic myeloid leukemia	CCND1,KRAS,TGFBR1,MYC,	8.55E-2
hsa05216	Thyroid cancer	CCND1,KRAS,MYC,	1.15E-1
hsa05215	Prostate cancer	CCND1,IGF1R,PDGFA,KRAS,	1.36E-1
hsa04060	Cytokine-cytokine receptor interaction	FAS,IL13,PDGFA,MPL,TGFBR1,IL6,	1.50E-1
hsa04110	Cell cycle	CCND1,BUB3,MYC,ESPL1,	3.32E-1
hsa05213	Endometrial cancer	CCND1,KRAS,MYC,	3.49E-1
hsa05221	Acute myeloid leukemia	CCND1,KRAS,MYC,	4.26E-1
hsa05212	Pancreatic cancer	CCND1,KRAS,TGFBR1,	6.27E-1
hsa04914	Progesterone-mediated oocyte maturation	IGF1R,ADCY9,KRAS,	8.55E-1
hsa04350	TGF-beta signaling pathway	TGFBR1,MYC,THBS1,	8.72E-1
hsa04540	Gap junction	PDGFA,ADCY9,KRAS,	9.07E-1

Gene ontology terms enriched for interacted genes

GO terms

GO terms description

target genes enrich in GO term

p-value

GO:0010604	positive regulation of macromolecule metabolic process	CCND1,ISL1,PDGFA,HAND1,H2AFX,MLL,DLC1,APP,IGF1R,NCOA1,ONECUT2,NR4A1,GLMN,SMARCAD1,DRD3,TGFBR1,IL6,MYC,THBS1,	2.43E-5
GO:0032268	regulation of cellular protein metabolic process	CCND1,PDGFA,SOCS1,MLL,DLC1,PDCD4,APP,IGF2BP3,IGF2BP1,BUB3,TNRC6A,TGFBR1,IL6,THBS1,	2.58E-5
GO:0010033	response to organic substance	CCND1,PDGFA,CALCOCO2,ADCY9,LIN28B,KRAS,SOCS1,CASP3,LIN28A,IGF1R,FAS,DICER1,DRD3,TGFBR1,IL6,THBS1,MYC,	3.82E-5
GO:0010557	positive regulation of macromolecule biosynthetic process	ISL1,PDGFA,HAND1,MLL,APP,IGF1R,NCOA1,ONECUT2,NR4A1,GLMN,SMARCAD1,DRD3,TGFBR1,IL6,MYC,THBS1,	4.72E-5
GO:0031328	positive regulation of cellular biosynthetic process	ISL1,PDGFA,HAND1,MLL,APP,IGF1R,NCOA1,ONECUT2,NR4A1,GLMN,SMARCAD1,DRD3,TGFBR1,IL6,MYC,THBS1,	7.98E-5

GO:0009891	positive regulation of biosynthetic process	ISL1,PDGFA,HAND1,MLL,APP,IGF1R,NCOA1,ONECUT2,NR4A1,GLMN,SMARCAD1,DRD3,TGFBR1,IL6,MYC,THBS1,	9.39E-5
GO:0045449	regulation of transcription	ZNF644,ZBTB39,BACH1,ZNF200,RFX5,KRAS,LIN28B,HMGA2,ZNF746,LIN28A,PDCD4,NCOA1,ARID3A,SMARCAD1,GCFC1,ABT1,TGFBR1,ISL1,PCGF3,HAND1,ZNF280B,MLL,ZNF763,PBX3,APP,ONECUT2,NR4A1,ZNF526,ZBTB24,DRD3,IL6,TLE4,MYC,ERC1,ZNF354B,	1.08E-4
GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	ISL1,PDGFA,HAND1,H2AFX,MLL,APP,IGF1R,NCOA1,ONECUT2,NR4A1,SMARCAD1,DRD3,TGFBR1,IL6,MYC,	1.09E-4
GO:0010608	posttranscriptional regulation of gene expression	IGF2BP3,DICER1,IGF2BP1,TNRC6A,LIN28B,IL6,LIN28A,THBS1,APP,	1.16E-4
GO:0019220	regulation of phosphate metabolic process	CCND1,PDGFA,ADCY9,KRAS,SOCS1,PDCD4,CASP3,DLC1,APP,GLMN,TGFBR1,IL6,THBS1,	1.44E-4
GO:0051174	regulation of phosphorus metabolic process	CCND1,PDGFA,ADCY9,KRAS,SOCS1,PDCD4,CASP3,DLC1,APP,GLMN,TGFBR1,IL6,THBS1,	1.44E-4
GO:0051173	positive regulation of nitrogen compound metabolic process	ISL1,PDGFA,HAND1,H2AFX,MLL,APP,IGF1R,NCOA1,ONECUT2,NR4A1,SMARCAD1,DRD3,TGFBR1,IL6,MYC,	1.52E-4
GO:0010605	negative regulation of macromolecule metabolic process	HAND1,RAD9A,LIN28B,RFX5,SOCS1,PDCD4,LIN28A,IGF2BP3,DICER1,IGF2BP1,BUB3,TNRC6A,DRD3,IL6,THBS1,MYC,	1.71E-4
GO:0040029	regulation of gene expression, epigenetic	DICER1,TNRC6A,GLMN,LIN28B,MLL,LIN28A,	2.03E-4
GO:0035195	gene silencing by miRNA	DICER1,TNRC6A,LIN28B,LIN28A,	2.12E-4
GO:0042127	regulation of cell proliferation	CCND1,IL13,PDGFA,KRAS,MLL,DLC1,CASP3,IGF1R,OPRM1,TPD52L2,GLMN,DRD3,TGFBR1,IL6,THBS1,MYC,	3.64E-4
GO:0048545	response to steroid hormone stimulus	CCND1,FAS,PDGFA,KRAS,SOCS1,TGFBR1,IL6,THBS1,	4.00E-4
GO:0016441	posttranscriptional gene silencing	DICER1,TNRC6A,LIN28B,LIN28A,	4.07E-4
GO:0035194	posttranscriptional gene silencing by RNA	DICER1,TNRC6A,LIN28B,LIN28A,	4.07E-4
GO:0042325	regulation of phosphorylation	CCND1,PDGFA,ADCY9,GLMN,KRAS,SOCS1,TGFBR1,IL6,PDCD4,CASP3,THBS1,APP,	4.13E-4
GO:0051726	regulation of cell cycle	CCND1,BUB3,RAD9A,DRD3,H2AFX,PDCD4,CASP3,MYC,APP,ESPL1,	5.22E-4
GO:0009719	response to endogenous stimulus	CCND1,IGF1R,FAS,PDGFA,ADCY9,KRAS,DRD3,SOCS1,TGFBR1,IL6,THBS1,	5.41E-4
GO:0051272	positive regulation of cell motion	IGF1R,PDGFA,ONECUT2,TGFBR1,IL6,THBS1,	6.23E-4
GO:0010562	positive regulation of phosphorus metabolic process	CCND1,GLMN,TGFBR1,IL6,DLC1,THBS1,	6.83E-4
GO:0045937	positive regulation of phosphate metabolic process	CCND1,GLMN,TGFBR1,IL6,DLC1,THBS1,	6.83E-4
GO:0031054	pre-microRNA processing	DICER1,LIN28B,LIN28A,	7.18E-4
GO:0044093	positive regulation of molecular function	CCND1,ADCY9,HOMER1,KRAS,DLC1,SLC11A2,OPRM1,DRD3,TGFBR1,IL6,ERC1,THBS1,MYC,	7.97E-4
GO:0007049	cell cycle	CCND1,SENP5,HMGA2,AKAP8,H2AFX,MLL,APP,ESPL1,CDC34,BUB3,CEP120,BIN3,PCNP,THBS1,MYC,	9.97E-4
GO:0009725	response to hormone stimulus	CCND1,IGF1R,FAS,PDGFA,ADCY9,KRAS,SOCS1,TGFBR1,IL6,THBS1,	1.08E-2
GO:0031399	regulation of protein modification process	CCND1,PDGFA,BUB3,SOCS1,TGFBR1,MLL,IL6,PDCD4,DLC1,	1.09E-2
GO:0009628	response to abiotic stimulus	CCND1,SLC12A2,KRAS,DRD3,H2AFX,TGFBR1,CASP3,MYC,THBS1,APP,	1.10E-2
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	ISL1,NCOA1,ONECUT2,NR4A1,HAND1,DRD3,MLL,IL6,MYC,APP,	1.17E-2
GO:0051052	regulation of DNA metabolic process	IGF1R,PDGFA,RAD9A,SMARCAD1,H2AFX,MYC,	1.23E-2
GO:0050865	regulation of cell activation	FAS,IL13,PDGFA,GLMN,IL6,CASP3,THBS1,	1.44E-2
GO:0031047	gene silencing by RNA	DICER1,TNRC6A,LIN28B,LIN28A,	1.57E-2
GO:0045941	positive regulation of transcription	ISL1,NCOA1,ONECUT2,NR4A1,HAND1,SMARCAD1,DRD3,TGFBR1,MLL,IL6,MYC,APP,	1.96E-2
GO:0040012	regulation of locomotion	IGF1R,PDGFA,ONECUT2,DRD3,IL6,DLC1,THBS1,	2.30E-2
GO:0051270	regulation of cell motion	IGF1R,PDGFA,ONECUT2,TGFBR1,IL6,DLC1,THBS1,	2.36E-2
GO:0010628	positive regulation of gene expression	ISL1,NCOA1,ONECUT2,NR4A1,HAND1,SMARCAD1,DRD3,TGFBR1,MLL,IL6,MYC,APP,	2.47E-2
GO:0006417	regulation of translation	IGF2BP3,IGF2BP1,TNRC6A,IL6,THBS1,APP,	2.76E-2
GO:0009314	response to radiation	CCND1,KRAS,DRD3,H2AFX,CASP3,MYC,APP,	2.82E-2
GO:0032880	regulation of protein localization	IL13,GLMN,CEP120,DRD3,TGFBR1,IL6,	2.85E-2
GO:0035196	gene silencing by miRNA, production of miRNAs	DICER1,LIN28B,LIN28A,	3.07E-2
GO:0006915	apoptosis	SLC11A2,FAS,KRAS,MLL,IL6,PDCD4,DLC1,CASP3,MYC,THBS1,APP,ESPL1,	3.24E-2
GO:0043085	positive regulation of catalytic activity	CCND1,SLC11A2,OPRM1,ADCY9,HOMER1,KRAS,DRD3,TGFBR1,DLC1,MYC,THBS1,	3.48E-2
GO:0030335	positive regulation of cell migration	IGF1R,PDGFA,ONECUT2,IL6,THBS1,	3.53E-2
GO:0031050	dsRNA fragmentation	DICER1,LIN28B,LIN28A,	3.61E-2
GO:0012501	programmed cell death	SLC11A2,FAS,KRAS,MLL,IL6,PDCD4,DLC1,CASP3,MYC,THBS1,APP,ESPL1,	3.63E-2
GO:0042981	regulation of apoptosis	RAD9A,KRAS,CASP3,DLC1,APP,IGF1R,SLC11A2,FAS,NR4A1,TGFBR1,IL6,RPS6,THBS1,MYC,	3.97E-2
GO:0007346	regulation of mitotic cell cycle	CCND1,BUB3,DRD3,MYC,APP,ESPL1,	4.31E-2
GO:0043067	regulation of programmed cell death	RAD9A,KRAS,CASP3,DLC1,APP,IGF1R,SLC11A2,FAS,NR4A1,TGFBR1,IL6,RPS6,THBS1,MYC,	4.32E-2
GO:0010941	regulation of cell death	RAD9A,KRAS,CASP3,DLC1,APP,IGF1R,SLC11A2,FAS,NR4A1,TGFBR1,IL6,RPS6,THBS1,MYC,	4.45E-2
GO:0042327	positive regulation of phosphorylation	CCND1,GLMN,TGFBR1,IL6,THBS1,	4.80E-2
GO:0040017	positive regulation of locomotion	IGF1R,PDGFA,ONECUT2,IL6,THBS1,	4.98E-2
GO:0050864	regulation of B cell activation	FAS,IL13,IL6,CASP3,	5.47E-2
GO:0022402	cell cycle process	CCND1,CDC34,BUB3,CEP120,HMGA2,AKAP8,H2AFX,MYC,THBS1,APP,ESPL1,	6.22E-2
GO:0002694	regulation of leukocyte activation	FAS,IL13,GLMN,IL6,CASP3,THBS1,	6.24E-2
GO:0045893	positive regulation of transcription, DNA-dependent	ISL1,NCOA1,ONECUT2,NR4A1,HAND1,DRD3,MLL,IL6,MYC,APP,	6.27E-2
GO:0051252	regulation of RNA metabolic process	ISL1,BACH1,HAND1,LIN28B,RFX5,HMGA2,ZNF746,MLL,ZNF763,LIN28A,PBX3,APP,NCOA1,ONECUT2,NR4A1,ARID3A,IGF2BP1,GCFC1,DRD3,IL6,MYC,ERC1,ZNF354B,	6.49E-2
GO:0051254	positive regulation of RNA metabolic process	ISL1,NCOA1,ONECUT2,NR4A1,HAND1,DRD3,MLL,IL6,MYC,APP,	6.61E-2
GO:0030334	regulation of cell migration	IGF1R,PDGFA,ONECUT2,IL6,DLC1,THBS1,	6.73E-2
GO:0016458	gene silencing	DICER1,TNRC6A,LIN28B,LIN28A,	7.10E-2
GO:0001932	regulation of protein amino acid phosphorylation	CCND1,PDGFA,SOCS1,TGFBR1,IL6,PDCD4,	7.41E-2
GO:0045787	positive regulation of cell cycle	CCND1,DRD3,APP,ESPL1,	7.46E-2
GO:0050708	regulation of protein secretion	IL13,GLMN,DRD3,IL6,	7.83E-2
GO:0010627	regulation of protein kinase cascade	DRD3,SOCS1,SLC20A1,TGFBR1,IL6,PDCD4,GOLT1B,	8.14E-2
GO:0051223	regulation of protein transport	IL13,GLMN,DRD3,TGFBR1,IL6,	8.45E-2
GO:0008284	positive regulation of cell proliferation	CCND1,IGF1R,IL13,PDGFA,KRAS,DRD3,TGFBR1,IL6,MYC,	8.60E-2
GO:0022403	cell cycle phase	CCND1,CDC34,BUB3,CEP120,HMGA2,AKAP8,H2AFX,APP,ESPL1,	8.60E-2
GO:0032269	negative regulation of cellular protein metabolic process	IGF2BP3,BUB3,IGF2BP1,TNRC6A,SOCS1,THBS1,	8.72E-2
GO:0050866	negative regulation of cell activation	FAS,PDGFA,GLMN,CASP3,	8.99E-2
GO:0006350	transcription	ZNF644,ZBTB39,BACH1,ZNF200,RFX5,HMGA2,ZNF746,NCOA1,ARID3A,GCFC1,ABT1,PCGF3,HAND1,ZNF280B,MLL,ZNF763,PBX3,ONECUT2,NR4A1,ZBTB24,ZNF526,POLR2D,TLE4,MYC,ZNF354B,	9.23E-2

KEGG pathways and Gene Ontology terms enriched for the interacted genes of ncRNA from RAID and miRTarBase.

disease name	related genes	p-value