Detail: | |
ncRNA Symmbol: | miR-1246 |
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ncRNA Category: | miRNA |
Interaction Gene Symbol: | RTKN2 |
Death Pathway: | apoptosis |
Expression Direction of ncRNA: | down |
Species: | Homo sapiens |
Tissue: | HaCaT cell |
PMID: | 24880483 |
Detail Description: | Overexpression of miR-1246 promoted UVB-induced apoptosis, while knockdown of miR-1246, using a specific inhibitor, resulted in a significant reduction in UVB-elicited apoptosis. We further demonstrate that miR-1246 negatively regulated the expression of RTKN2 through binding to the 3'-untranslated region of RTKN2 at the posttranscriptional level. Moreover, RTKN2 was observed to be resistant to UVB-induced apoptosis and RTKN2 antagonized the pro-apoptotic effects of miR-1246 during UVB-induced apoptosis in HaCaT cells. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting entry with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting entry with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.