| Detail: | |
| ncRNA Symmbol: | miR-124 |
|---|---|
| ncRNA Category: | miRNA |
| Interaction Gene Symbol: | STAT3 |
| Death Pathway: | apoptosis |
| Expression Direction of ncRNA: | down |
| Species: | Homo sapiens |
| Tissue: | brain |
| PMID: | 23928694 |
| Detail Description: | Vitamin shortage also affected upstream kinases of Stat3 signaling pathway (phospho-Erk1/2, phospho-Src, phospho-JNK, and phospho-p38) as well as downstream target gene products (Bcl-2 and Bcl-xL), thus promoting apoptosis.Conversely, the expression of the Stat3 regulator miR-124 was upregulated in deficiency conditions. Furthermore, miR-124 siRNA improved the phenotype of deprived cells, with enhanced neurite outgrowth.Taken together, our data suggest that downregulation of Stat3 signaling by miR-124 would be a key factor in the deleterious effects of MDD on brain development. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting entry with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting entry with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.