The Detail Information for This Interaction


  • Detail
  • Binding
  • Network
Detail:
ncRNA Symmbol:miR-122
ncRNA Category:miRNA
Interaction Gene Symbol:
Death Pathway:apoptosis
Expression Direction of ncRNA:
Species:Homo sapiens
Tissue:hepatocellular carcinoma cell
PMID: 24085423
Detail Description:

After treatment with 5-aza-2-deoxycytidine, the Huh7 and HepG2 cell lines displayed a significantly lower degree of methylation, and the levels of miRNA-122 expression were significantly higher than those in the blank group. Compared with the blank group, apoptosis of Huh7 and HepG2 cells was significantly increased. We concluded that the expression of miRNA-122 is regulated by DNA methylation and correlated with apoptosis of liver cancer cells. 

Select the ncRNA symbol and transcript of gene
Mature of miR-122    Transcript of    
Visualization:
Select the center nodes: First Node Second Node Both the Nodes
Select the Level of Neighbour: First Neighbour Second Neighbour

The 'First Node' or 'Second Node' option represents the sub-network of interacting entry with the first or second interaction node, the 'Both the Nodes' option represents the sub-network of interacting entry with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node, the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node. Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.


The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.