The Detail Information for This Interaction


  • Detail
  • Binding
  • Network
Detail:
ncRNA Symmbol:p53-mRNA
ncRNA Category:lncRNA
Interaction Gene Symbol: PITX1
Death Pathway:apoptosis
Expression Direction of ncRNA:
Species:Homo sapiens
Tissue:mammary carcinoma cells
PMID: 17762884
Detail Description:

Increased p53 mrna expression was due to activation of the p53 promoter by hPitx1. Forced expression of hpitx1 resulted in cell-cycle arrest and p53-dependent apoptosis in p53-replete MCF-7 cells. Furthermore, hPitx1 stimulated the transcription of p53 target genes involved in cell-cycle arrest and apoptosis (p21 and ptgf-beta), again in a p53-dependent manner.Depletion of p53 by sirna dramatically attenuated hpitx1-induced apoptosis in MCF-7 cells. 

Select the ncRNA symbol and transcript of gene
lncRNA symbol :     Transcript of PITX1    
Visualization:
Select the center nodes: First Node Second Node Both the Nodes
Select the Level of Neighbour: First Neighbour Second Neighbour

The 'First Node' or 'Second Node' option represents the sub-network of interacting entry with the first or second interaction node, the 'Both the Nodes' option represents the sub-network of interacting entry with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node, the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node. Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.


The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.