The Detail Information for This Interaction


  • Detail
  • Binding
  • Network
Detail:
ncRNA Symmbol:ANRIL
ncRNA Category:lncRNA
Interaction Gene Symbol: E2F1
Death Pathway:apoptosis
Expression Direction of ncRNA:
Species:Homo sapiens
Tissue:
PMID: 23416462
Detail Description:

Consistent with the results from the apoptosis assays, depletion of ANRIL resulted in an increase in the sensitivity of HCT116 p53+/+ cells to the treatment with neocarzinostatin (NCS), confirming that lowered levels of ANRIL in cells led to elevated apoptosis in the DNA damage response(DDR).In the present study, we demonstrate that one specific lncRNA, ANRIL, is transcriptionally up-regulated by the transcription factor E2F1 in an ATM-dependent manner following DNA damage,  

Select the ncRNA symbol and transcript of gene
lncRNA symbol :     Transcript of E2F1    
Visualization:
Select the center nodes: First Node Second Node Both the Nodes
Select the Level of Neighbour: First Neighbour Second Neighbour

The 'First Node' or 'Second Node' option represents the sub-network of interacting entry with the first or second interaction node, the 'Both the Nodes' option represents the sub-network of interacting entry with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node, the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node. Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.


The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.