| Detail: | |
| ncRNA Symmbol: | miR-146a |
|---|---|
| ncRNA Category: | miRNA |
| Interaction Gene Symbol: | SMAD4 |
| Death Pathway: | apoptosis |
| Expression Direction of ncRNA: | down |
| Species: | Homo sapiens |
| Tissue: | osteoarthritis |
| PMID: | 22507670 |
| Detail Description: | Smad4, a common mediator of the TGF-¦Â pathway, is identified as a direct target of miR-146a by harboring a miR-146a binding sequence in the 3'-UTR region of its mRNA.Expression of miR-146a led to a reduction of cellular responsiveness to TGF-¦Â and an increase of apoptosis rate in chondrocytes. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting entry with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting entry with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.