The Detail Information for This Interaction


  • Detail
  • Binding
  • Network
Detail:
ncRNA Symmbol:miR-101
ncRNA Category:miRNA
Interaction Gene Symbol: FOS
Death Pathway:apoptosis
Expression Direction of ncRNA:down
Species:Homo sapiens
Tissue:endometrial
PMID: 25153722
Detail Description:

Here, we report that in aggressive endometrial cancer cells, re-expression of microRNA-101 leads to inhibition of cell proliferation and induction of apoptosis and senescence.we validated EZH2, MCL-1 and FOS as direct targets of miR-101 and silencing of these genes mimics the tumor suppressive effects observed on promoting microRNA-101 function. 

Select the ncRNA symbol and transcript of gene
Mature of miR-101    Transcript of FOS    
Visualization:
Select the center nodes: First Node Second Node Both the Nodes
Select the Level of Neighbour: First Neighbour Second Neighbour

The 'First Node' or 'Second Node' option represents the sub-network of interacting entry with the first or second interaction node, the 'Both the Nodes' option represents the sub-network of interacting entry with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node, the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node. Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.


The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.