| Detail: | |
| ncRNA Symmbol: | let-7a |
|---|---|
| ncRNA Category: | miRNA |
| Interaction Gene Symbol: | MIR21 |
| Death Pathway: | apoptosis |
| Expression Direction of ncRNA: | down |
| Species: | Homo sapiens |
| Tissue: | cholesteatoma keratinocytes |
| PMID: | 25405753 |
| Detail Description: | Considering the function of miR-21 in the regulation of proliferation and apoptosis, let-7a may control cell proliferation and apoptosis by regulating miR-21, and its targets, in cholesteatoma keratinocytes.In conclusion, the present study showed that let?7a downregulates the expression of miR-21, resulting in the suppression of proliferation and induction of apoptosis. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting entry with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting entry with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.