| Detail: | |
| ncRNA Symmbol: | miR-638 |
|---|---|
| ncRNA Category: | miRNA |
| Interaction Gene Symbol: | TFAP2A |
| Death Pathway: | apoptosis |
| Expression Direction of ncRNA: | up |
| Species: | Homo sapiens |
| Tissue: | melanoma cell |
| PMID: | 25650662 |
| Detail Description: | MRNA expression profiling identified new candidate genes including TP53INP2 as miR-638 targets. Overexpression of TP53INP2 severely attenuated proliferative and invasive capacity of melanoma cells which was reversed by miR-638. Depletion of miR-638 stimulated expression of p53 and p53 downstream target genes and induced apoptosis and autophagy. miR-638 promoter analysis identified the miR-638 target transcription factor associated protein 2¦Á (TFAP2A/AP-2¦Á) as a direct negative regulator of miR-638, suggestive for a double-negative regulatory feedback loop. Taken together, miR-638 supports melanoma progression and suppresses p53-mediated apoptosis pathways, autophagy and expression of the transcriptional repressor TFAP2A/AP-2¦Á. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting entry with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting entry with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.