Detail: | |
ncRNA Symmbol: | miR-381 |
---|---|
ncRNA Category: | miRNA |
Interaction Gene Symbol: | WEE1 |
Death Pathway: | apoptosis |
Expression Direction of ncRNA: | down |
Species: | Homo sapiens |
Tissue: | renal cancer cells |
PMID: | 23816136 |
Detail Description: | miR-381 combined with 5-FU led to Cd c2activation, mitotic catastrophe, and cell apoptosis through inhibitory WEE1. WEE1 was also validated as the direct target of miR-381.miR-381, a novel intrinsic WEE1 inhibitor, sensitizes renal cancer cells to 5-FU by upregulationof Cdc2 activities in 786-O. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting entry with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting entry with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.