| Detail: | |
| ncRNA Symmbol: | miR-34a |
|---|---|
| ncRNA Category: | miRNA |
| Interaction Gene Symbol: | PDGFRA |
| Death Pathway: | apoptosis |
| Expression Direction of ncRNA: | down |
| Species: | Homo sapiens |
| Tissue: | lung tumor cells |
| PMID: | 23805317 |
| Detail Description: | MiR-34a/c-Dependent PDGFR-¦Á/¦Â Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer. miR-34a/c overexpression or downregulation of PDGFR-¦Á/¦Â by siRNAs, strongly augmented the response to TNF-related apoptosis inducing ligand (TRAIL) while reducing migratory and invasive capacity of NSCLC cells.we found that miR-34a and miR-34c target platelet-derived growth factor receptor alpha and beta (PDGFR-¦Á and PDGFR-¦Â), cell surface tyrosine kinase receptors that induce proliferation, migration and invasion in cancer.Moreover, we identified an inverse correlation between PDGFR-¦Á/¦Â and miR-34a/c expression in lung tumor samples. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting entry with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting entry with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.