| Detail: | |
| ncRNA Symmbol: | miR-346 |
|---|---|
| ncRNA Category: | miRNA |
| Interaction Gene Symbol: | VDR |
| Death Pathway: | apoptosis |
| Expression Direction of ncRNA: | down |
| Species: | Homo sapiens |
| Tissue: | bowel |
| PMID: | 25192497 |
| Detail Description: | We recently reported that the gut epithelial vitamin D receptor (VDR) signaling inhibits colitis through inhibition of intestinal epithelial cell apoptosis, and the level of colonic epithelial VDR is markedly reduced in patients with inflammatory bowel diseases (IBD). VDR downregulation promotes colitis, but the mechanism underlying VDR downregulation in IBD is unknown. e showed that tumor necrosis factor ¦Á (TNF-¦Á) suppresses VDR expression while simultaneously upregulating miR-346 in human colon cancer cells. Further studies demonstrated that miR-346 inhibits VDR by a specific target sequence in the 3' untranslated region of the human VDR transcript, and blockade of miR-346 with a hairpin inhibitor abrogates the ability of TNF-¦Á to inhibit VDR, confirming that TNF-¦Á downregulates VDR by inducing miR-346. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting entry with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting entry with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.