Detail: | |
ncRNA Symmbol: | miR-221 |
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ncRNA Category: | miRNA |
Interaction Gene Symbol: | BCL2 |
Death Pathway: | apoptosis |
Expression Direction of ncRNA: | down |
Species: | Homo sapiens |
Tissue: | bladder cancer cell |
PMID: | 25585941 |
Detail Description: | In this study, miR?221 inhibitor was transfected into bladder cancer cell lines 5637, J82 and T24 to repress the expression of miR?221. As a result, the repression of miR?221 on p53 upregulated modulator of apoptosis (PUMA) was abolished, resulting in increased expression of the pro-apoptotic Bax and reduced expression of the anti-apoptotic Bcl-2, which promotes apoptosis of bladder cancer cells. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting entry with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting entry with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.