Detail: | |
ncRNA Symmbol: | miR-21 |
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ncRNA Category: | miRNA |
Interaction Gene Symbol: | |
Death Pathway: | apoptosis |
Expression Direction of ncRNA: | down |
Species: | Homo sapiens |
Tissue: | colon cancer cell |
PMID: | 24427170 |
Detail Description: | Recent studies showed that silencing of miR21 through use of a miR21 inhibitor (anti-miR21) affected viability, apoptosis and the cell cycle in colon cancer cells. We identified an anti-miR21 that targets miR21 to inhibit genes by both post-transcriptional gene silencing and transcriptional gene silencing in the cytoplasm and nucleus, respectively. Overexpression of anti-miR21 in colon cancer cells caused changes in miRNA expression levels. We found that treatment with anti-miR21 down-regulated expression of miR30, which is involved in angiogenesis. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting entry with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting entry with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.