| Detail: | |
| ncRNA Symmbol: | miR-21 |
|---|---|
| ncRNA Category: | miRNA |
| Interaction Gene Symbol: | TNF |
| Death Pathway: | apoptosis |
| Expression Direction of ncRNA: | |
| Species: | Homo sapiens |
| Tissue: | cardiomyocytes |
| PMID: | 23710745 |
| Detail Description: | MicroRNA-21 reduced TNF-¦Á induced cardiomyocytes apoptosis [(23.42 ¡À 1.98)% vs. (78.37 ¡À 2.03)%, P < 0.05]. TNF-¦Á downregulated the expression of microRNA-21 and upregulated the mRNA and protein expressions of PTEN. Phosphorylation of PTEN, AKT and FOXO3a was enhanced in cardiomyocytes transfected with lenti-microRNA-21 (P < 0.05). TNF-¦Á also significantly activated the phosphorylation of PTEN, AKT and FOXO3a (P < 0.05). Compared with cardiomyocytes treated with TNF-¦Á (10 ng/ml), the phosphorylation of PTEN, AKT and FOXO3a as well as expression of pPTEN, pAKTser473, pFOXO3a and FasL were significantly suppressed in cardiomyocytes treated with lenti-microRNA-21 and TNF-¦Á (P < 0.05). Total AKT and FOXO3a were similar among all groups (P > 0.05). |
The 'First Node' or 'Second Node' option represents the sub-network of interacting entry with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting entry with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.