The Detail Information for This Interaction


  • Detail
  • Binding
  • Network
Detail:
ncRNA Symmbol:miR-16
ncRNA Category:miRNA
Interaction Gene Symbol: ATG7
Death Pathway:autophagy
Expression Direction of ncRNA:down
Species:Homo sapiens
Tissue:HeLa cell
PMID: 23143396
Detail Description:

Levels of miR-16 and let-7a, measured by Northern blot or RT-qPCR, indeed decreased significantly in cells treated with siRNAs targeting NDP52, ATG5 or ATG7, but not p62, for an extended period of 4 days (Fig.4a-b). In contrast, pre-miR-16 and pre-let-7a levels were not overtly modified (Fig.4a-c) suggesting that prolonged defects in autophagy specifically affect miRNA stability after pre-miRNA processing, but before miRISC formation and activity. 

Select the ncRNA symbol and transcript of gene
Mature of miR-16    Transcript of ATG7    
Visualization:
Select the center nodes: First Node Second Node Both the Nodes
Select the Level of Neighbour: First Neighbour Second Neighbour

The 'First Node' or 'Second Node' option represents the sub-network of interacting entry with the first or second interaction node, the 'Both the Nodes' option represents the sub-network of interacting entry with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node, the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node. Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.


The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.