id miRNA_symbol miRBase_mature_ID miRBase_ID RNA Category Gene_Symbol Pathway Action_Mode Organism Tissue PMID tax_id geneid Synonyms Links chromosome map_location Description type_of_gene Full_name_from_nomenclature_authority Other_designations Description 1 let-7 hsa-let-7a-5p,hsa-let-7b-5p,hsa-let-7d-5p,hsa-let-7e-5p,hsa-let-7f-5p,hsa-let-7g-5p,hsa-let-7i-5p,hsa-let-7a-3p,hsa-let-7b-3p,hsa-let-7d-3p,hsa-let-7e-3p,hsa-let-7f-1-3p,hsa-let-7f-2-3p,hsa-let-7g-3p,hsa-let-7i-3p,hsa-let-7a-2-3p,hsa-let-7c-5p, MIMAT0000062,MIMAT0000063,MIMAT0000065,MIMAT0000066,MIMAT0000067,MIMAT0000414,MIMAT0000415,MIMAT0004481,MIMAT0004482,MIMAT0004484,MIMAT0004485,MIMAT0004486,MIMAT0004487,MIMAT0004584,MIMAT0004585,MIMAT0010195,MIMAT0000064 miRNA ain-1 autophagy down Caenorhabditis elegans 23619095 6239 181719 - - X - Protein AIN-1 protein-coding - Loss of autophagy activity suppresses developmental defects caused by partially impaired silencing of miRNA targets including the let-7 family and lsy-6. The C. elegans GW182 homolog AIN-1 is itself selectively degraded by autophagy and colocalizes with the p62 homolog SQST-1 in autophagy mutants. Thus, autophagy activity modulates miRNA-mediated gene silencing and degrades a core miRISC component. 2 lsy-6 cel-lsy-6-3p,cel-lsy-6-5p MIMAT0000749,MIMAT0031896 miRNA ain-1 autophagy down Caenorhabditis elegans 23619095 6239 181719 - - X - Protein AIN-1 protein-coding - Loss of autophagy activity suppresses developmental defects caused by partially impaired silencing of miRNA targets including the let-7 family and lsy-6. The C. elegans GW182 homolog AIN-1 is itself selectively degraded by autophagy and colocalizes with the p62 homolog SQST-1 in autophagy mutants. Thus, autophagy activity modulates miRNA-mediated gene silencing and degrades a core miRISC component. 3 miR-34 cel-miR-34-5p,cel-miR-34-3p MIMAT0000005,MIMAT0015093 miRNA atg-9 autophagy down Caenorhabditis elegans 22081425 6239 178561 - - V - Protein ATG-9 protein-coding - MiR-34 modulates Caenorhabditis elegans lifespan via repressing the autophagy gene atg9. 4 miR-34 cel-miR-34-3p,cel-miR-34-3p MIMAT0000005,MIMAT0015093 miRNA cep-1 apoptosis Caenorhabditis elegans 19421141 6239 172616 - - I - Protein CEP-1 protein-coding - MiRNA expression is also affected by DNA damaging agents, such as radiation. In particular, mammalian miR-34 is upregulated by p53 in response to radiation, but little is known about the role of this miRNA in vivo. Here we show that Caenorhabditis elegans with loss-of-function mutations in the mir-34 gene have an abnormal cellular survival response to radiation; these animals are highly radiosensitive in the soma and radioresistant in the germline. These findings show a role for mir-34 in both apoptotic and non-apoptotic cell death in vivo, much like that of cep-1, the C. elegans p53 homolog. 5 miR-14 dme-miR-14-5p,dme-miR-14-3p MIMAT0020798,MIMAT0000120 miRNA IP3K2 autophagy Drosophila melanogaster salivary gland cell 25306920 7227 Here, we identify the microRNA miR-14 as being both necessary and sufficient for autophagy during developmentally regulated cell death in Drosophila. Loss of miR-14 prevented induction of autophagy during salivary gland cell death, but had no effect on starvation-induced autophagy in the fat body. Moreover, misexpression of miR-14 was sufficient to prematurely induce autophagy in salivary glands, but not in the fat body. Importantly, miR-14 regulates this context-specific autophagy through its target, inositol 1,4,5-trisphosphate kinase 2 (ip3k2), thereby affecting inositol 1,4,5-trisphosphate (IP3) signaling and calcium levels during salivary gland cell death. 6 hsr omega transcripts http://lncrna.com/hsromegatranscripts/ lncRNA caspases apoptosis Drosophila melanogaster eye disc cells 19737742 7227 39753 0736/01|1065/03|CG12284|D-IAP1|D-iap1|DIAP|DIAP I|DIAP-1|DIAP1|DIAPI|Diap|Diap-1|Diap-1/Th|Diap1|Diap2|Dmel\CG12284|E(rpr)3-1|IAP|IAP1|Iap1|S048915|TH|dIAP|dIAP-1|dIAP1|dIap1|diap|diap 1|diap-1|diap1|diap1/thread|l(3)72CDe|l(3)72Dc|l(3)S030605|l(3)S030605b|l(3)S106503|l(3)j5C8 FLYBASE:FBgn0260635 3L 72C1-72D1|3-43.2 cM thread protein-coding thread diaphanous-related formin The large nucleus limited noncoding hsromega-n RNA of Drosophila melanogaster is known to associate with a variety of heterogeneous nuclear RNA-binding proteins (hnRNPs) and certain other RNA-binding proteins to assemble the nucleoplasmic omega speckles. In this article, we show that RNAi-mediated depletion of this noncoding RNA dominantly suppresses apoptosis, in eye and other imaginal discs, triggered by induced expression of Rpr, Grim, or caspases (initiator as well as effector), all of which are key regulators/effectors of the canonical caspase-mediated cell death pathway. We also show, for the first time, a genetic interaction between the noncoding hsromega transcripts and the c-Jun N-terminal kinase (JNK) signaling pathway since downregulation of hsromega transcripts suppressed JNK activation. In addition, hsromega-RNAi also augmented the levels of Drosophila Inhibitor of Apoptosis Protein 1 (DIAP1) when apoptosis was activated. 7 hsr omega transcripts http://lncrna.com/hsromegatranscripts/ lncRNA grim apoptosis Drosophila melanogaster eye disc cells 19737742 7227 40014 BcDNA:RE28551|CG4345|Dmel\CG4345|GRIM|Grim|gri|grm FLYBASE:FBgn0015946 3L 75C4-75C4 CG4345 gene product from transcript CG4345-RA protein-coding - diaphanous-related formin The large nucleus limited noncoding hsromega-n RNA of Drosophila melanogaster is known to associate with a variety of heterogeneous nuclear RNA-binding proteins (hnRNPs) and certain other RNA-binding proteins to assemble the nucleoplasmic omega speckles. In this article, we show that RNAi-mediated depletion of this noncoding RNA dominantly suppresses apoptosis, in eye and other imaginal discs, triggered by induced expression of Rpr, Grim, or caspases (initiator as well as effector), all of which are key regulators/effectors of the canonical caspase-mediated cell death pathway. We also show, for the first time, a genetic interaction between the noncoding hsromega transcripts and the c-Jun N-terminal kinase (JNK) signaling pathway since downregulation of hsromega transcripts suppressed JNK activation. In addition, hsromega-RNAi also augmented the levels of Drosophila Inhibitor of Apoptosis Protein 1 (DIAP1) when apoptosis was activated. 8 hsr omega transcripts http://lncrna.com/hsromegatranscripts/ lncRNA RpII215 apoptosis Drosophila melanogaster 17536179 7227 32100 5|8WG16|CG1554|CTD|Dmel\CG1554|H5|II|IIo|L5|POL|Pol II|Pol II CTD|Pol II Ser5P|Pol II Ser5p|Pol II0[ser2]|Pol II0[ser5]|Pol II[ser2]|Pol IIa|Pol IIo|Pol IIo[Ser2]|Pol IIo[ser2]|Pol IIo[ser5]|Pol-IIa|PolII|PolIIa|PolIIo|PolIIo[ser2]|PolIIo[ser5]|RNA Pol II|RNA Pol II CTD|RNA PolI 215|RNA PolII|RNA pol II|RNA pol IIo|RNA polII|RNA-PolII|RNAP|RNAP II|RNAP II LS|RNAPII|RNAPII0|RNApol2|RNApolII|RPB1|RPII215|RpII|Rpb1|Rpll215|Ser5-P Pol II|Ubl|alphaPol IIo[ser2]|dRPB1|dRpb1|l(1)10Ca|l(1)DC912|l(1)DF912|l(1)G0040|l(1)L5|pol II|polII|rpII1 FLYBASE:FBgn0003277 X 10C6-10C6|1-35.66 cM RNA polymerase II 215kD subunit protein-coding RNA polymerase II 215kD subunit Studies in our laboratory also reveal that absence or reduced levels of the developmentally active as well as stress induced non-coding hsr omega transcripts, which are known to sequester diverse hnRNPs and related nuclear RNA-binding proteins,block induced apoptosis in Drosophila. 9 hsr omega transcripts http://lncrna.com/hsromegatranscripts/ lncRNA rpr apoptosis Drosophila melanogaster eye disc cells 19737742 7227 40015 CG4319|Dmel\CG4319|RPR|Rpr|anon-WO0162936.19|rp FLYBASE:FBgn0011706 3L 75C6-75C6 reaper protein-coding reaper diaphanous-related formin The large nucleus limited noncoding hsromega-n RNA of Drosophila melanogaster is known to associate with a variety of heterogeneous nuclear RNA-binding proteins (hnRNPs) and certain other RNA-binding proteins to assemble the nucleoplasmic omega speckles. In this article, we show that RNAi-mediated depletion of this noncoding RNA dominantly suppresses apoptosis, in eye and other imaginal discs, triggered by induced expression of Rpr, Grim, or caspases (initiator as well as effector), all of which are key regulators/effectors of the canonical caspase-mediated cell death pathway. We also show, for the first time, a genetic interaction between the noncoding hsromega transcripts and the c-Jun N-terminal kinase (JNK) signaling pathway since downregulation of hsromega transcripts suppressed JNK activation. In addition, hsromega-RNAi also augmented the levels of Drosophila Inhibitor of Apoptosis Protein 1 (DIAP1) when apoptosis was activated. 10 hsr omega transcripts http://lncrna.com/hsromegatranscripts/ lncRNA th apoptosis up Drosophila melanogaster eye disc cells 19737742 7227 39753 0736/01|1065/03|CG12284|D-IAP1|D-iap1|DIAP|DIAP I|DIAP-1|DIAP1|DIAPI|Diap|Diap-1|Diap-1/Th|Diap1|Diap2|Dmel\CG12284|E(rpr)3-1|IAP|IAP1|Iap1|S048915|TH|dIAP|dIAP-1|dIAP1|dIap1|diap|diap 1|diap-1|diap1|diap1/thread|l(3)72CDe|l(3)72Dc|l(3)S030605|l(3)S030605b|l(3)S106503|l(3)j5C8 FLYBASE:FBgn0260635 3L 72C1-72D1|3-43.2 cM thread protein-coding thread diaphanous-related formin The large nucleus limited noncoding hsromega-n RNA of Drosophila melanogaster is known to associate with a variety of heterogeneous nuclear RNA-binding proteins (hnRNPs) and certain other RNA-binding proteins to assemble the nucleoplasmic omega speckles. In this article, we show that RNAi-mediated depletion of this noncoding RNA dominantly suppresses apoptosis, in eye and other imaginal discs, triggered by induced expression of Rpr, Grim, or caspases (initiator as well as effector), all of which are key regulators/effectors of the canonical caspase-mediated cell death pathway. We also show, for the first time, a genetic interaction between the noncoding hsromega transcripts and the c-Jun N-terminal kinase (JNK) signaling pathway since downregulation of hsromega transcripts suppressed JNK activation. In addition, hsromega-RNAi also augmented the levels of Drosophila Inhibitor of Apoptosis Protein 1 (DIAP1) when apoptosis was activated. 11 bantam dme-bantam-5p,dme-bantam-3p MIMAT0020823,MIMAT0000365 miRNA W apoptosis down Drosophila melanogaster wing disc 12679032 7227 40009 CG5123|Dmel\CG5123|HID|Hid|Hid1|hid|hid1|his|l(3)05014 FLYBASE:FBgn0003997 3L 75C1-75C1 Wrinkled protein-coding Wrinkled CG5123-PA|W-PA|head invol Bantam expression is temporally and spatially regulated in response to patterning cues. bantam microRNA simultaneously stimulates cell proliferation and prevents apoptosis. We identify the pro-apoptotic gene hid as a target for regulation by bantam miRNA, providing an explanation for bantam's anti-apoptotic activity. 12 miR-11 dme-miR-11-3p,dme-miR-11-5p MIMAT0000116,MIMAT0020793 miRNA rpr apoptosis Drosophila melanogaster embryos 22095284 7227 40015 CG4319|Dmel\CG4319|RPR|Rpr|anon-WO0162936.19|rp FLYBASE:FBgn0011706 3L 75C6-75C6 reaper protein-coding reaper CG5123-PA|W-PA|head invol MiR-6/11 functions through regulation of the proapoptotic genes, reaper (rpr), head involution defective(hid), grim and sickle (skl). Upregulation of these proapoptotic genes is responsible for the elevated apoptosis and the CNS defects in the mutants. 13 miR-11 dme-miR-11-3p,dme-miR-11-5p MIMAT0000116,MIMAT0020793 miRNA skl apoptosis Drosophila melanogaster embryos 22095284 7227 40016 BcDNA:RE14076|CG13701|Dmel\CG13701|Skl|meph|veto FLYBASE:FBgn0036786 3L 75C6-75C6 sickle protein-coding sickle CG13701-PA|mephisto|skl-P MiR-6/11 functions through regulation of the proapoptotic genes, reaper (rpr), head involution defective(hid), grim and sickle (skl). Upregulation of these proapoptotic genes is responsible for the elevated apoptosis and the CNS defects in the mutants. 14 miR-11 dme-miR-11-3p,dme-miR-11-5p MIMAT0000116,MIMAT0020793 miRNA W apoptosis Drosophila melanogaster embryos 22095284 7227 40009 CG5123|Dmel\CG5123|HID|Hid|Hid1|hid|hid1|his|l(3)05014 FLYBASE:FBgn0003997 3L 75C1-75C1 Wrinkled protein-coding Wrinkled CG5123-PA|W-PA|head invol MiR-6/11 functions through regulation of the proapoptotic genes, reaper (rpr), head involution defective(hid), grim and sickle (skl). Upregulation of these proapoptotic genes is responsible for the elevated apoptosis and the CNS defects in the mutants. 15 miR-14 dme-miR-14-5p,dme-miR-14-3p MIMAT0020798,MIMAT0000120 miRNA Ice apoptosis down Drosophila melanogaster larvae and adult 12725740 7227 43514 CG7788|DRICE|Dmel\CG7788|DrICE|DrIce|Drice|Drive|ICE|caspase 3|crice|drICE|drIce|drice|ice FLYBASE:FBgn0019972 3R 99C1-99C1 CG7788 gene product from transcript CG7788-RA protein-coding - CG7788-PA|Ice-PA|caspase- Mir-14 mutants have elevated levels of the apoptotic effector caspase Drice, suggesting one potential site of action. Mir-14 also regulates fat metabolism. 16 miR-263a dme-miR-263a-5p,dme-miR-263a-3p MIMAT0000319,MIMAT0020799 miRNA apoptosis Drosophila melanogaster 20563308 7227 MiR-263a/b are members of a conserved family of microRNAs that are expressed in peripheral sense organs across the animal kingdom. Here we present evidence that miR-263a and miR-263b play a role in protecting Drosophila mechanosensory bristles from apoptosis by down-regulating the pro-apoptotic gene head involution defective. 17 miR-263b dme-miR-263a-5p,dme-miR-263a-3p MIMAT0000319,MIMAT0020799 miRNA apoptosis Drosophila melanogaster 20563308 7227 MiR-263a/b are members of a conserved family of microRNAs that are expressed in peripheral sense organs across the animal kingdom. Here we present evidence that miR-263a and miR-263b play a role in protecting Drosophila mechanosensory bristles from apoptosis by down-regulating the pro-apoptotic gene head involution defective. 18 miR-6 dme-mir-6-5p,dme-miR-6-3p MIMAT0020787,MIMAT0000111 miRNA rpr apoptosis Drosophila melanogaster embryos 22095284 7227 40015 CG4319|Dmel\CG4319|RPR|Rpr|anon-WO0162936.19|rp FLYBASE:FBgn0011706 3L 75C6-75C6 reaper protein-coding reaper CG5123-PA|W-PA|head invol MiR-6/11 functions through regulation of the proapoptotic genes, reaper (rpr), head involution defective(hid), grim and sickle (skl). Upregulation of these proapoptotic genes is responsible for the elevated apoptosis and the CNS defects in the mutants. 19 miR-6 dme-mir-6-5p,dme-miR-6-3p MIMAT0020787,MIMAT0000111 miRNA skl apoptosis Drosophila melanogaster embryos 22095284 7227 40016 BcDNA:RE14076|CG13701|Dmel\CG13701|Skl|meph|veto FLYBASE:FBgn0036786 3L 75C6-75C6 sickle protein-coding sickle CG13701-PA|mephisto|skl-P MiR-6/11 functions through regulation of the proapoptotic genes, reaper (rpr), head involution defective(hid), grim and sickle (skl). Upregulation of these proapoptotic genes is responsible for the elevated apoptosis and the CNS defects in the mutants. 20 miR-6 dme-mir-6-5p,dme-miR-6-3p MIMAT0020787,MIMAT0000111 miRNA W apoptosis Drosophila melanogaster embryos 22095284 7227 40009 CG5123|Dmel\CG5123|HID|Hid|Hid1|hid|hid1|his|l(3)05014 FLYBASE:FBgn0003997 3L 75C1-75C1 Wrinkled protein-coding Wrinkled CG5123-PA|W-PA|head invol MiR-6/11 functions through regulation of the proapoptotic genes, reaper (rpr), head involution defective(hid), grim and sickle (skl). Upregulation of these proapoptotic genes is responsible for the elevated apoptosis and the CNS defects in the mutants. 21 miR-8 dme-miR-8-5p,dme-miR-8-3p MIMAT0020791,MIMAT0000113 miRNA Gug apoptosis Drosophila melanogaster brain 17923093 7227 46156 Atro|CG6964|Dmel\CG6964|GUG|atro|gug|l(3)01323|l(3)03928|l(3)S146907|l(3)j5A3|l(3)rO116 FLYBASE:FBgn0010825 3L 66C13-66D1|3-26 cM Grunge protein-coding Grunge CG6964-PA|CG6964-PB|CG696 MiR-8 mutant phenotypes are attributable to elevated atrophin activity, resulting in elevated apoptosis in the brain and in behavioral defects. Reduction of atrophin levels in miR-8-expressing cells to below the level generated by miR-8 regulation is detrimental, providing evidence for a "tuning target" relationship between them.? 22 let-7k miRNA apoptosis Danio rerio embryos 22298809 7955 The miRNA expression profiles obtained reveal significant miRNA deregulation and show that both ethanol concentrations upregulate miR-153a, miR-725, miR 30d, let-7k, miR-100, miR-738, and miR-732. Putative gene targets of deregulated miRNAs are involved in cell cycle control, apoptosis, and transcription, which are the main processes affected by ethanol toxicity. 23 miR-100 dre-miR-100 MIMAT0001813 miRNA apoptosis Danio rerio embryos 22298809 7955 The miRNA expression profiles obtained reveal significant miRNA deregulation and show that both ethanol concentrations upregulate miR-153a, miR-725, miR 30d, let-7k, miR-100, miR-738, and miR-732. Putative gene targets of deregulated miRNAs are involved in cell cycle control, apoptosis, and transcription, which are the main processes affected by ethanol toxicity. 24 miR-125b dre-miR-125b-5p,dre-miR-125b-1-5p MIMAT0001821,MIMAT0031963 miRNA tp53 apoptosis down Danio rerio brain 19293287 7955 30590 brp53|drp53|etID22686.5|fb40d06|p53|wu:fb40d06|zgc:111919 ZFIN:ZDB-GENE-990415-270|Ensembl:ENSDARG00000035559|Vega:OTTDARG00000016232 5 - tumor protein p53 protein-coding tumor protein p53 Overexpression of miR-125b represses the endogenous level of p53 protein and suppresses apoptosis in human neuroblastoma cells and human lung fibroblast cells. In contrast, knockdown of miR-125b elevates the level of p53 protein and induces apoptosis in human lung fibroblasts and in the zebrafish brain. 25 miR-153a dre-miR-153a MIMAT0001849 miRNA apoptosis Danio rerio embryos 22298809 7955 The miRNA expression profiles obtained reveal significant miRNA deregulation and show that both ethanol concentrations upregulate miR-153a, miR-725, miR 30d, let-7k, miR-100, miR-738, and miR-732. Putative gene targets of deregulated miRNAs are involved in cell cycle control, apoptosis, and transcription, which are the main processes affected by ethanol toxicity. 26 miR-30a dre-miR-30a-5p,dre-miR-30a-3p MIMAT0001803,MIMAT0031951 miRNA six1a apoptosis down Danio rerio 24634509 7955 494168 six1b|six2|zgc:92332 ZFIN:ZDB-GENE-040718-155|Ensembl:ENSDARG00000039304|Vega:OTTDARG00000022888 13 - SIX homeobox 1a protein-coding SIX homeobox 1a Overexpression of miR30a leads to a reduction in six1a/b levels, and results in increased apoptosis and altered somite morphology, which phenocopies six1a/b knockdown.? 27 miR-30a dre-miR-30a-5p,dre-miR-30a-3p MIMAT0001803,MIMAT0031951 miRNA six1b apoptosis down Danio rerio 24634509 7955 404627 six1|zgc:77345 ZFIN:ZDB-GENE-040426-2308 20 - SIX homeobox 1b protein-coding SIX homeobox 1b Overexpression of miR30a leads to a reduction in six1a/b levels, and results in increased apoptosis and altered somite morphology, which phenocopies six1a/b knockdown.? 28 miR-30d dre-miR-30d MIMAT0001806 miRNA apoptosis Danio rerio embryos 22298809 7955 The miRNA expression profiles obtained reveal significant miRNA deregulation and show that both ethanol concentrations upregulate miR-153a, miR-725, miR 30d, let-7k, miR-100, miR-738, and miR-732. Putative gene targets of deregulated miRNAs are involved in cell cycle control, apoptosis, and transcription, which are the main processes affected by ethanol toxicity. 29 miR-725 dre-miR-725 MIMAT0003753 miRNA apoptosis Danio rerio embryos 22298809 7955 The miRNA expression profiles obtained reveal significant miRNA deregulation and show that both ethanol concentrations upregulate miR-153a, miR-725, miR 30d, let-7k, miR-100, miR-738, and miR-732. Putative gene targets of deregulated miRNAs are involved in cell cycle control, apoptosis, and transcription, which are the main processes affected by ethanol toxicity. 30 miR-732 dre-miR-732 MIMAT0003762 miRNA apoptosis Danio rerio embryos 22298809 7955 The miRNA expression profiles obtained reveal significant miRNA deregulation and show that both ethanol concentrations upregulate miR-153a, miR-725, miR 30d, let-7k, miR-100, miR-738, and miR-732. Putative gene targets of deregulated miRNAs are involved in cell cycle control, apoptosis, and transcription, which are the main processes affected by ethanol toxicity. 31 miR-738 dre-miR-738 MIMAT0003769 miRNA apoptosis Danio rerio embryos 22298809 7955 The miRNA expression profiles obtained reveal significant miRNA deregulation and show that both ethanol concentrations upregulate miR-153a, miR-725, miR 30d, let-7k, miR-100, miR-738, and miR-732. Putative gene targets of deregulated miRNAs are involved in cell cycle control, apoptosis, and transcription, which are the main processes affected by ethanol toxicity. 32 miR-92a dre-miR-92a-2-5p,dre-miR-92a-5p,dre-miR-92a-3p MIMAT0031954,MIMAT0031953,MIMAT0001808 miRNA nog3 apoptosis down Danio rerio Craniofacial cell 23410941 7955 30173 - ZFIN:ZDB-GENE-990714-8|Ensembl:ENSDARG00000079003 12 - noggin 3 protein-coding noggin 3 The Bmp antagonist gene noggin3 (nog3) is a direct target of mir92a. Inactivation of mir92a stabilizes nog3 mRNA, leading to repression of Bmp signaling and abnormal behaviors of chondrogenic progenitors. In contrast, ectopic expression of mir92a duplex decreases nog3 mRNA levels and, as a result, derepresses Bmp signaling and promotes cell apoptosis. 33 miR-125b miRNA itchb apoptosis Danio rerio 21935352 7955 170770 PUMA|PUMA/JFY1 MGI:2181667|Ensembl:ENSMUSG00000002083|Vega:OTTMUSG00000022267 7 7 A2|7 BCL2 binding component 3 protein-coding BCL2 binding component 3 By using a gain- and loss-of-function screen for miR-125b targets in humans, mice, and zebrafish and by validating these targets with the luciferase assay and a novel miRNA pull-down assay, we demonstrate that miR-125b directly represses 20 novel targets in the p53 network.These targets include both apoptosis regulators like Bak1, Igfbp3, Itch, Puma, Prkra, Tp53inp1, Tp53, Zac1 34 miR-125b miRNA tp53inp1 apoptosis Danio rerio 21935352 7955 568021 cb1036|wu:fb70a09|wu:fi13h08|zgc:158431 ZFIN:ZDB-GENE-031018-3|Ensembl:ENSDARG00000028017|Vega:OTTDARG00000027895 16 - tumor protein p53 inducible nuclear protein 1 protein-coding tumor protein p53 inducible nuclear protein 1 By using a gain- and loss-of-function screen for miR-125b targets in humans, mice, and zebrafish and by validating these targets with the luciferase assay and a novel miRNA pull-down assay, we demonstrate that miR-125b directly represses 20 novel targets in the p53 network.These targets include both apoptosis regulators like Bak1, Igfbp3, Itch, Puma, Prkra, Tp53inp1, Tp53, Zac1 35 miR-143 miRNA KLF5 apoptosis Gallus gallus 20064147 9031 418818 - CGNC:12707|Ensembl:ENSGALG00000016927 1 - Kruppel-like factor 5 (intestinal) protein-coding Kruppel-like factor 5 (intestinal) Many of these genes are associated with cell proliferation, apoptosis and tumourigenesis. Six of the up-regulated genes possess at least one potential miR-143 binding site in their 3'UTRs, of these the binding sites of PYCR2, PSTPIP1 and PDCD5 were validated by an in vitro luciferase reporter assay. In addition, several potential targets with important biological functions were identified by the miRanda algorithm and experimentally confirmed. These targets include KLF5, MAP3K7, TARDBP and UBE2E3, which have conserved miR-143 binding sites across multiple vertebrate species. Potential chicken specific miR-143 target sites were also validated for LPIN1, PCK2, PYCR2, METTL14, SLC2A2 and TNFSF10. Overall, the current study suggests that miR-143 is ubiquitously expressed among tissues and is likely to be involved in the regulation of cell proliferation and apoptosis. 36 miR-143 miRNA MAP3K7 apoptosis Gallus gallus 20064147 9031 421808 - CGNC:11625|Ensembl:ENSGALG00000015596 3 - mitogen-activated protein kinase kinase kinase 7 protein-coding mitogen-activated protein kinase kinase kinase 7 Many of these genes are associated with cell proliferation, apoptosis and tumourigenesis. Six of the up-regulated genes possess at least one potential miR-143 binding site in their 3'UTRs, of these the binding sites of PYCR2, PSTPIP1 and PDCD5 were validated by an in vitro luciferase reporter assay. In addition, several potential targets with important biological functions were identified by the miRanda algorithm and experimentally confirmed. These targets include KLF5, MAP3K7, TARDBP and UBE2E3, which have conserved miR-143 binding sites across multiple vertebrate species. Potential chicken specific miR-143 target sites were also validated for LPIN1, PCK2, PYCR2, METTL14, SLC2A2 and TNFSF10. Overall, the current study suggests that miR-143 is ubiquitously expressed among tissues and is likely to be involved in the regulation of cell proliferation and apoptosis. 37 miR-143 miRNA METTL14 apoptosis Gallus gallus 20064147 9031 422684 - CGNC:51803|Ensembl:ENSGALG00000012000 4 - methyltransferase like 14 protein-coding methyltransferase like 14 Many of these genes are associated with cell proliferation, apoptosis and tumourigenesis. Six of the up-regulated genes possess at least one potential miR-143 binding site in their 3'UTRs, of these the binding sites of PYCR2, PSTPIP1 and PDCD5 were validated by an in vitro luciferase reporter assay. In addition, several potential targets with important biological functions were identified by the miRanda algorithm and experimentally confirmed. These targets include KLF5, MAP3K7, TARDBP and UBE2E3, which have conserved miR-143 binding sites across multiple vertebrate species. Potential chicken specific miR-143 target sites were also validated for LPIN1, PCK2, PYCR2, METTL14, SLC2A2 and TNFSF10. Overall, the current study suggests that miR-143 is ubiquitously expressed among tissues and is likely to be involved in the regulation of cell proliferation and apoptosis. 38 miR-143 miRNA PCK2 apoptosis Gallus gallus 20064147 9031 396457 PEPCK-M CGNC:49813 Un - phosphoenolpyruvate carboxykinase 2 (mitochondrial) protein-coding phosphoenolpyruvate carboxykinase 2 (mitochondrial) Many of these genes are associated with cell proliferation, apoptosis and tumourigenesis. Six of the up-regulated genes possess at least one potential miR-143 binding site in their 3'UTRs, of these the binding sites of PYCR2, PSTPIP1 and PDCD5 were validated by an in vitro luciferase reporter assay. In addition, several potential targets with important biological functions were identified by the miRanda algorithm and experimentally confirmed. These targets include KLF5, MAP3K7, TARDBP and UBE2E3, which have conserved miR-143 binding sites across multiple vertebrate species. Potential chicken specific miR-143 target sites were also validated for LPIN1, PCK2, PYCR2, METTL14, SLC2A2 and TNFSF10. Overall, the current study suggests that miR-143 is ubiquitously expressed among tissues and is likely to be involved in the regulation of cell proliferation and apoptosis. 39 miR-143 miRNA PDCD5 apoptosis Gallus gallus 20064147 9031 415765 - CGNC:3442|Ensembl:ENSGALG00000004648 11 - programmed cell death 5 protein-coding programmed cell death 5 Many of these genes are associated with cell proliferation, apoptosis and tumourigenesis. Six of the up-regulated genes possess at least one potential miR-143 binding site in their 3'UTRs, of these the binding sites of PYCR2, PSTPIP1 and PDCD5 were validated by an in vitro luciferase reporter assay. In addition, several potential targets with important biological functions were identified by the miRanda algorithm and experimentally confirmed. These targets include KLF5, MAP3K7, TARDBP and UBE2E3, which have conserved miR-143 binding sites across multiple vertebrate species. Potential chicken specific miR-143 target sites were also validated for LPIN1, PCK2, PYCR2, METTL14, SLC2A2 and TNFSF10. Overall, the current study suggests that miR-143 is ubiquitously expressed among tissues and is likely to be involved in the regulation of cell proliferation and apoptosis. 40 miR-143 miRNA PSTPIP1 apoptosis Gallus gallus 20064147 9031 415349 - CGNC:2009 10 - proline-serine-threonine phosphatase interacting protein 1 protein-coding proline-serine-threonine phosphatase interacting protein 1 Many of these genes are associated with cell proliferation, apoptosis and tumourigenesis. Six of the up-regulated genes possess at least one potential miR-143 binding site in their 3'UTRs, of these the binding sites of PYCR2, PSTPIP1 and PDCD5 were validated by an in vitro luciferase reporter assay. In addition, several potential targets with important biological functions were identified by the miRanda algorithm and experimentally confirmed. These targets include KLF5, MAP3K7, TARDBP and UBE2E3, which have conserved miR-143 binding sites across multiple vertebrate species. Potential chicken specific miR-143 target sites were also validated for LPIN1, PCK2, PYCR2, METTL14, SLC2A2 and TNFSF10. Overall, the current study suggests that miR-143 is ubiquitously expressed among tissues and is likely to be involved in the regulation of cell proliferation and apoptosis. 41 miR-143 miRNA PYCR2 apoptosis Gallus gallus 20064147 9031 769203 - CGNC:55066|Ensembl:ENSGALG00000007300 18 - pyrroline-5-carboxylate reductase family, member 2 protein-coding pyrroline-5-carboxylate reductase family, member 2 Many of these genes are associated with cell proliferation, apoptosis and tumourigenesis. Six of the up-regulated genes possess at least one potential miR-143 binding site in their 3'UTRs, of these the binding sites of PYCR2, PSTPIP1 and PDCD5 were validated by an in vitro luciferase reporter assay. In addition, several potential targets with important biological functions were identified by the miRanda algorithm and experimentally confirmed. These targets include KLF5, MAP3K7, TARDBP and UBE2E3, which have conserved miR-143 binding sites across multiple vertebrate species. Potential chicken specific miR-143 target sites were also validated for LPIN1, PCK2, PYCR2, METTL14, SLC2A2 and TNFSF10. Overall, the current study suggests that miR-143 is ubiquitously expressed among tissues and is likely to be involved in the regulation of cell proliferation and apoptosis. 42 miR-143 miRNA SLC2A2 apoptosis Gallus gallus 20064147 9031 396272 GLUT2 CGNC:49728|Ensembl:ENSGALG00000009306 9 - solute carrier family 2 (facilitated glucose transporter), member 2 protein-coding solute carrier family 2 (facilitated glucose transporter), member 2 Many of these genes are associated with cell proliferation, apoptosis and tumourigenesis. Six of the up-regulated genes possess at least one potential miR-143 binding site in their 3'UTRs, of these the binding sites of PYCR2, PSTPIP1 and PDCD5 were validated by an in vitro luciferase reporter assay. In addition, several potential targets with important biological functions were identified by the miRanda algorithm and experimentally confirmed. These targets include KLF5, MAP3K7, TARDBP and UBE2E3, which have conserved miR-143 binding sites across multiple vertebrate species. Potential chicken specific miR-143 target sites were also validated for LPIN1, PCK2, PYCR2, METTL14, SLC2A2 and TNFSF10. Overall, the current study suggests that miR-143 is ubiquitously expressed among tissues and is likely to be involved in the regulation of cell proliferation and apoptosis. 43 miR-143 miRNA TARDBP apoptosis Gallus gallus 20064147 9031 419453 - CGNC:2099|Ensembl:ENSGALG00000002906 21 - TAR DNA binding protein protein-coding TAR DNA binding protein Many of these genes are associated with cell proliferation, apoptosis and tumourigenesis. Six of the up-regulated genes possess at least one potential miR-143 binding site in their 3'UTRs, of these the binding sites of PYCR2, PSTPIP1 and PDCD5 were validated by an in vitro luciferase reporter assay. In addition, several potential targets with important biological functions were identified by the miRanda algorithm and experimentally confirmed. These targets include KLF5, MAP3K7, TARDBP and UBE2E3, which have conserved miR-143 binding sites across multiple vertebrate species. Potential chicken specific miR-143 target sites were also validated for LPIN1, PCK2, PYCR2, METTL14, SLC2A2 and TNFSF10. Overall, the current study suggests that miR-143 is ubiquitously expressed among tissues and is likely to be involved in the regulation of cell proliferation and apoptosis. 44 miR-143 miRNA TNFSF10 apoptosis Gallus gallus 20064147 9031 378894 TRAIL CGNC:6980|Ensembl:ENSGALG00000009179 9 - tumor necrosis factor (ligand) superfamily, member 10 protein-coding tumor necrosis factor (ligand) superfamily, member 10 Many of these genes are associated with cell proliferation, apoptosis and tumourigenesis. Six of the up-regulated genes possess at least one potential miR-143 binding site in their 3'UTRs, of these the binding sites of PYCR2, PSTPIP1 and PDCD5 were validated by an in vitro luciferase reporter assay. In addition, several potential targets with important biological functions were identified by the miRanda algorithm and experimentally confirmed. These targets include KLF5, MAP3K7, TARDBP and UBE2E3, which have conserved miR-143 binding sites across multiple vertebrate species. Potential chicken specific miR-143 target sites were also validated for LPIN1, PCK2, PYCR2, METTL14, SLC2A2 and TNFSF10. Overall, the current study suggests that miR-143 is ubiquitously expressed among tissues and is likely to be involved in the regulation of cell proliferation and apoptosis. 45 miR-143 miRNA UBE2E3 apoptosis Gallus gallus 20064147 9031 424122 - CGNC:14325|Ensembl:ENSGALG00000020793 7 - ubiquitin-conjugating enzyme E2E 3 protein-coding ubiquitin-conjugating enzyme E2E 3 Many of these genes are associated with cell proliferation, apoptosis and tumourigenesis. Six of the up-regulated genes possess at least one potential miR-143 binding site in their 3'UTRs, of these the binding sites of PYCR2, PSTPIP1 and PDCD5 were validated by an in vitro luciferase reporter assay. In addition, several potential targets with important biological functions were identified by the miRanda algorithm and experimentally confirmed. These targets include KLF5, MAP3K7, TARDBP and UBE2E3, which have conserved miR-143 binding sites across multiple vertebrate species. Potential chicken specific miR-143 target sites were also validated for LPIN1, PCK2, PYCR2, METTL14, SLC2A2 and TNFSF10. Overall, the current study suggests that miR-143 is ubiquitously expressed among tissues and is likely to be involved in the regulation of cell proliferation and apoptosis. 46 miR-15a gga-miR-15a MIMAT0001117 miRNA BCL2 apoptosis down Gallus gallus lung 24887070 9031 396282 bcl-2 CGNC:9759|Ensembl:ENSGALG00000012885 2 - B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 When chicks were incubated in low oxygen (hypoxia), miR-15a was significantly increased in embryonic lung tissue.Bcl-2 was a translationally repressed target of miR-15a in these chickens. 47 miR-21 gga-miR-21-5p,gga-miR-21-3p MIMAT0003774,MIMAT0026643 miRNA PDCD4 apoptosis down Gallus gallus 23055556 9031 374191 - CGNC:6604|Ensembl:ENSGALG00000008700 6 - programmed cell death 4 (neoplastic transformation inhibitor) protein-coding programmed cell death 4 (neoplastic transformation inhibitor) We mapped the gga-miR-21 promoter to the 10th intron of the TMEM49 gene and found it to be driven by AP-1- and Ets-responsive elements. We show here that the viral oncoprotein Meq binds to this promoter, thereby transactivating gga-miR-21 expression. We confirmed that this miRNA targets chicken programmed death cell 4 (PDCD4) and promotes tumor cell growth and apoptosis escape. 48 miR-M3(MDV1) mdv1-miR-M3-5p,mdv1-miR-M3-3p MIMAT0003923,MIMAT0009207 miRNA SMAD2 apoptosis down Gallus gallus T-cell 20962090 9031 395247 MADH2 CGNC:49229|Ensembl:ENSGALG00000014697 Z - SMAD family member 2 protein-coding SMAD family member 2 MDV1-miR-M3 suppressed cisplatin-induced apoptosis by directly downregulating expression at the protein but not the mRNA level of Smad2, a critical component in the transforming growth factor ¦Â signal pathway. 49 BC200 http://lncrna.com/BC200/ lncRNA necrosis Homo sapiens 25645334 9606 TUG1, BC200 and MIR156HG are down regulated when necrosis is induced using a high dose of DOX in both cell lines. 50 HOTAIR http://lncrna.com/hotair/ lncRNA necrosis Homo sapiens sarcoma 23543869 9606 High levels of both MTDH/AEG-1 and HOTAIR in primary sarcoma are correlated with a high probability of metastasis. By contrast, reduced expressio of both MTDH/AEG-1 and HOTAIR is correlated with a good response to treatment in terms of necrosis, 51 TUG1 lncRNA necrosis Homo sapiens 25645334 9606 TUG1, BC200 and MIR155HG are down regulated when necrosis is induced using a high dose of DOX in both cell lines. 52 miR-155 hsa-miR-155-5p,hsa-miR-155-3p MIMAT0000646,MIMAT0004658 miRNA RIPK1 necrosis down Homo sapiens cardiomyocyte progenitor cells 20550618 9606 8737 RIP|RIP1 HGNC:10019|MIM:603453|Ensembl:ENSG00000137275|HPRD:04583|Vega:OTTHUMG00000014134 6 6p25.2 receptor (TNFRSF)-interacting serine-threonine kinase 1 protein-coding receptor (TNFRSF)-interacting serine-threonine kinase 1 RIP-1|cell death protein Microrna-155 prevents necrotic cell death in human cardiomyocyte progenitor cells via targeting RIP1. 53 miR-155hg hsa-miR-155-5p,hsa-miR-155-3p MIMAT0000646,MIMAT0004658 miRNA necrosis Homo sapiens 25645334 9606 TUG1, BC200 and MIR157HG are down regulated when necrosis is induced using a high dose of DOX in both cell lines. 54 miR-24 hsa-miR-24-1-5p,hsa-miR-24-3p,hsa-miR-24-2-5p MIMAT0000079,MIMAT0000080,MIMAT0004497 miRNA BCL2L11 necrosis down Homo sapiens 23098654 9606 10018 BAM|BIM|BOD HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 2 2q13 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) MiR-24 resulted in the largest LDH release, lowest cell viability and highest apoptosis and necrosis rates in normal and ischemic myocytes. Additionally, the mRNA and protein levels of the pro-apoptotic gene, BCL2L11, were down-regulated by miR-24 overexpression and up-regulated by miR-24 deficiency. The luciferase reporter assay confirmed BCL2L11 to be a target of miR-24. 55 miR-874 hsa-miR-874-3p,hsa-miR-874-5p MIMAT0004911,MIMAT0026718 miRNA CASP8 necrosis down Homo sapiens heart 23828572 9606 841 ALPS2B|CAP4|Casp-8|FLICE|MACH|MCH5 HGNC:1509|MIM:601763|Ensembl:ENSG00000064012|HPRD:03459|Vega:OTTHUMG00000132821 2 2q33-q34 caspase 8, apoptosis-related cysteine peptidase protein-coding caspase 8, apoptosis-related cysteine peptidase When suppressed by miR-874, caspase-8 lost the ability to repress necrotic program. In exploring the molecular mechanism by which miR-874 expression is regulated, we identified that Foxo3a could transcriptionally repress miR-874 expression. 56 BANCR http://lncrna.com/bancr/ lncRNA MAP1LC3A autophagy down Homo sapiens papillary thyroid carcinoma 25289082 9606 84557 ATG8E|LC3|LC3A|MAP1ALC3|MAP1BLC3 HGNC:6838|MIM:601242|Ensembl:ENSG00000101460|HPRD:03144|Vega:OTTHUMG00000032306 20 20q11.22 microtubule-associated protein 1 light chain 3 alpha protein-coding microtubule-associated protein 1 light chain 3 alpha In addition,the overexpression of BANCR resulted in an increase in the ratio of LC3-II/LC3-I,a marker for autophagy, while the knockdown of BANCR decreased the ratio of LC3-II/LC3-I. 57 BANCR http://lncrna.com/bancr/ lncRNA MAP1LC3B autophagy up Homo sapiens papillary thyroid carcinoma 25289082 9606 81631 ATG8F|LC3B|MAP1A/1BLC3|MAP1LC3B-a HGNC:13352|MIM:609604|Ensembl:ENSG00000140941|HPRD:14358|Vega:OTTHUMG00000137654 16 16q24.2 microtubule-associated protein 1 light chain 3 beta protein-coding microtubule-associated protein 1 light chain 3 beta In addition,the overexpression of BANCR resulted in an increase in the ratio of LC3-II/LC3-I,a marker for autophagy, while the knockdown of BANCR decreased the ratio of LC3-II/LC3-I. 58 FLJ11812 lncRNA ATG13 autophagy Homo sapiens human umbilical vein endothelial cells 24879147 9606 9776 KIAA0652|PARATARG8 HGNC:29091|MIM:615088|Ensembl:ENSG00000175224|HPRD:13809|Vega:OTTHUMG00000166538 11 11p11.2 autophagy related 13 protein-coding autophagy related 13 In previous studies, we found a chemical small molecule, 3-benzyl-5-((2-nitrophenoxy) methyl)-dihydrofuran-2(3H)-one (3BDO), that inhibited autophagy in human umbilical vein endothelial cells (HUVECs) and neuronal cells.Finally, we used gene microarray, RNA interference, RNA-ChIP assay, bioinformatics, luciferase reporter assay, and other assays and found that 3BDO greatly decreased the level of a long noncoding RNA (lncRNA) derived from the 3' untranslated region (3'UTR) of TGFB2, known as FLJ11812.Further experiments results showed that FLJ11812 could bind with MIR4459 targeting ATG13 (autophagy-related 13), and ATG13 protein level was decreased along with 3BDO-decreased FLJ11812 level. 59 HULC http://lncrna.com/HULC/ lncRNA autophagy Homo sapiens gastric 24247585 9606 Mechanistically, we discovered that overexpression of HULC could induce patterns of autophagy in SGC7901 cells; more importantly, autophagy inhibition increased overexpression of HULC cell apoptosis. 60 MEG3 http://lncrna.com/MEG3/ lncRNA MAP1LC3B autophagy down Homo sapiens bladder cancer cell lines 23295831 9606 81631 ATG8F|LC3B|MAP1A/1BLC3|MAP1LC3B-a HGNC:13352|MIM:609604|Ensembl:ENSG00000140941|HPRD:14358|Vega:OTTHUMG00000137654 16 16q24.2 microtubule-associated protein 1 light chain 3 beta protein-coding microtubule-associated protein 1 light chain 3 beta A significant negative correlation was observed between MEG3 levels and LC3-II (autophagy marker) levels in vivo. We further demonstrated that MEG3 markedly suppressed autophagy activation, whereas MEG3 knockdown activated autophagy in human bladder cancer cell lines. 61 let-7 hsa-let-7a-5p,hsa-let-7a-3p,hsa-let-7a-2-3p,hsa-let-7b-5p,hsa-let-7b-3p,hsa-let-7c-5p,hsa-let-7c-3p,hsa-let-7d-5p,hsa-let-7d-3p,hsa-let-7e-5p,hsa-let-7e-3p,hsa-let-7g-5p,hsa-let-7g-3p,hsa-let-7i-5p,hsa-let-7i-3p MIMAT0000062,MIMAT0004481,MIMAT0010195,MIMAT0000063,MIMAT0004482,MIMAT0000064,MIMAT0026472,MIMAT0000065,MIMAT0004484,MIMAT0000066,MIMAT0004485,MIMAT0004486,MIMAT0000414,MIMAT0004584,MIMAT0000415,MIMAT0004585 miRNA MTOR autophagy down Homo sapiens brain cell 25295787 9606 2475 FRAP|FRAP1|FRAP2|RAFT1|RAPT1 HGNC:3942|MIM:601231|Ensembl:ENSG00000198793|HPRD:03134|Vega:OTTHUMG00000002001 1 1p36.2 mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) We found that let-7 activates autophagy by coordinately downregulating the amino acid sensing pathway to prevent mTORC1 activation. Let-7 induced autophagy in the brain to eliminate protein aggregates, establishing its physiological relevance for in vivo autophagy modulation. 62 let-7a hsa-let-7a-5p,hsa-let-7a-3p,hsa-let-7a-2-3p MIMAT0000062,MIMAT0004481,MIMAT0010195 miRNA ATG5 autophagy down Homo sapiens HeLa cell 23143396 9606 9474 APG5|APG5-LIKE|APG5L|ASP|hAPG5 HGNC:589|MIM:604261|Ensembl:ENSG00000057663|HPRD:16051|Vega:OTTHUMG00000016193 6 6q21 autophagy related 5 protein-coding autophagy related 5 Levels of miR-16 and let-7a, measured by Northern blot or RT-qPCR, indeed decreased significantly in cells treated with siRNAs targeting NDP52, ATG5 or ATG7, but not p62, for an extended period of 4 days (Fig.4a-b). In contrast, pre-miR-16 and pre-let-7a levels were not overtly modified (Fig.4a-c) suggesting that prolonged defects in autophagy specifically affect miRNA stability after pre-miRNA processing, but before miRISC formation and activity. 63 let-7a hsa-let-7a-5p,hsa-let-7a-3p,hsa-let-7a-2-3p MIMAT0000062,MIMAT0004481,MIMAT0010195 miRNA ATG7 autophagy down Homo sapiens HeLa cell 23143396 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 Levels of miR-16 and let-7a, measured by Northern blot or RT-qPCR, indeed decreased significantly in cells treated with siRNAs targeting NDP52, ATG5 or ATG7, but not p62, for an extended period of 4 days (Fig.4a-b). In contrast, pre-miR-16 and pre-let-7a levels were not overtly modified (Fig.4a-c) suggesting that prolonged defects in autophagy specifically affect miRNA stability after pre-miRNA processing, but before miRISC formation and activity. 64 let-7a hsa-let-7a-5p,hsa-let-7a-3p,hsa-let-7a-2-3p MIMAT0000062,MIMAT0004481,MIMAT0010195 miRNA CALCOCO2 autophagy down Homo sapiens HeLa cell 23143396 9606 10241 NDP52 HGNC:29912|MIM:604587|Ensembl:ENSG00000136436|HPRD:06846|Vega:OTTHUMG00000160505 17 17q21.32 calcium binding and coiled-coil domain 2 protein-coding calcium binding and coiled-coil domain 2 Levels of miR-16 and let-7a, measured by Northern blot or RT-qPCR, indeed decreased significantly in cells treated with siRNAs targeting NDP52, ATG5 or ATG7, but not p62, for an extended period of 4 days (Fig.4a-b). In contrast, pre-miR-16 and pre-let-7a levels were not overtly modified (Fig.4a-c) suggesting that prolonged defects in autophagy specifically affect miRNA stability after pre-miRNA processing, but before miRISC formation and activity. 65 let-7a hsa-let-7a-5p,hsa-let-7a-3p,hsa-let-7a-2-3p MIMAT0000062,MIMAT0004481,MIMAT0010195 miRNA autophagy Homo sapiens hepatocellular carcinoma 25429777 9606 Chol-let-7a inhibited the viability and mobility of HCC cells. Chol-let-7a was primarily observed in the cytoplasm and induced organelle changes including autophagy. Mild changes were observed in the cells treated with negative control miRNA. 66 let-7f-1 hsa-let-7f-1-3p MIMAT0004486 miRNA HMGB1 autophagy up Homo sapiens medulloblastomacells 25014664 9606 3146 HMG1|HMG3|SBP-1 HGNC:4983|MIM:163905|Ensembl:ENSG00000189403|HPRD:01228|Vega:OTTHUMG00000016670 13 13q12 high mobility group box 1 protein-coding high mobility group box 1 SPARC expression suppressed miR-let-7f-1 expression which resulted in disruptedrepression of High Mobility Group Box 1 (HMGB1), a critical regulator ofautophagy. 67 miR-100 hsa-miR-100-5p,hsa-miR-100-3p MIMAT0000098,MIMAT0004512 miRNA IGF1R autophagy down Homo sapiens HCC cells 25026290 9606 3480 CD221|IGFIR|IGFR|JTK13 HGNC:5465|MIM:147370|Ensembl:ENSG00000140443|HPRD:00932|Vega:OTTHUMG00000149851 15 15q26.3 insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor MicroRNA-100 promotes the autophagy of hepatocellular carcinoma cells by inhibiting the expression of mTOR and IGF-1R. 68 miR-100 hsa-miR-100-5p,hsa-miR-100-3p MIMAT0000098,MIMAT0004512 miRNA MTOR autophagy down Homo sapiens HCC cells 25026290 9606 2475 FRAP|FRAP1|FRAP2|RAFT1|RAPT1 HGNC:3942|MIM:601231|Ensembl:ENSG00000198793|HPRD:03134|Vega:OTTHUMG00000002001 1 1p36.2 mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) MicroRNA-100 promotes the autophagy of hepatocellular carcinoma cells by inhibiting the expression of mTOR and IGF-1R. 69 miR-101 hsa-miR-101-5p,hsa-miR-101-3p MIMAT0004513,MIMAT0000099 miRNA ATG4D autophagy Homo sapiens breast cancer cells 21915098 9606 84971 APG4-D|APG4D|AUTL4 HGNC:20789|MIM:611340|Ensembl:ENSG00000130734|HPRD:07005|Vega:OTTHUMG00000180582 19 19p13.2 autophagy related 4D, cysteine peptidase protein-coding autophagy related 4D, cysteine peptidase APG4 autophagy 4 homolog Through transcriptome profiling, we identified three novel miR-101 targets, STMN1, RAB5A and ATG4D. siRNA-mediated depletion of these genes phenocopied the effect of miR-101 overexpression, demonstrating their importance in autophagy regulation. 70 miR-101 hsa-miR-101-5p,hsa-miR-101-3p MIMAT0004513,MIMAT0000099 miRNA ATG4D autophagy down Homo sapiens 22902544 9606 84971 APG4-D|APG4D|AUTL4 HGNC:20789|MIM:611340|Ensembl:ENSG00000130734|HPRD:07005|Vega:OTTHUMG00000180582 19 19p13.2 autophagy related 4D, cysteine peptidase protein-coding autophagy related 4D, cysteine peptidase Several miRNA regulators of this step have been identified including miR-30a, miR-181a and miR-374a (ATG5), miR-630 (ATG12), miR-376b (ATG4), miR-204 (LC3), miR-375 (ATG7), miR-519a (ATG10 and ATG16), miR-885-3p (ATG16) and miR-101 (ATG4 and RAB5A) 71 miR-101 hsa-miR-101-5p,hsa-miR-101-3p MIMAT0004513,MIMAT0000099 miRNA ATG4D autophagy Homo sapiens HepG2 cell line 23483142 9606 84971 APG4-D|APG4D|AUTL4 HGNC:20789|MIM:611340|Ensembl:ENSG00000130734|HPRD:07005|Vega:OTTHUMG00000180582 19 19p13.2 autophagy related 4D, cysteine peptidase protein-coding autophagy related 4D, cysteine peptidase MiR-101 inhibited autophagy via targets including RAB5A, STMN1 and ATG4D. 72 miR-101 hsa-miR-101-5p,hsa-miR-101-3p MIMAT0004513,MIMAT0000099 miRNA RAB5A autophagy Homo sapiens breast cancer cells 21915098 9606 5868 RAB5 HGNC:9783|MIM:179512|Ensembl:ENSG00000144566|HPRD:01542|Vega:OTTHUMG00000129889 3 3p24-p22 RAB5A, member RAS oncogene family protein-coding RAB5A, member RAS oncogene family leukemia-associated phosp Through transcriptome profiling, we identified three novel miR-101 targets, STMN1, RAB5A and ATG4D. siRNA-mediated depletion of these genes phenocopied the effect of miR-101 overexpression, demonstrating their importance in autophagy regulation. 73 miR-101 hsa-miR-101-5p,hsa-miR-101-3p MIMAT0004513,MIMAT0000099 miRNA RAB5A autophagy Homo sapiens HepG2 cell line 23483142 9606 5868 RAB5 HGNC:9783|MIM:179512|Ensembl:ENSG00000144566|HPRD:01542|Vega:OTTHUMG00000129889 3 3p24-p22 RAB5A, member RAS oncogene family protein-coding RAB5A, member RAS oncogene family MiR-101 inhibited autophagy via targets including RAB5A, STMN1 and ATG4D. 74 miR-101 hsa-miR-101-5p,hsa-miR-101-3p MIMAT0004513,MIMAT0000099 miRNA STMN1 autophagy Homo sapiens breast cancer cells 21915098 9606 3925 C1orf215|LAP18|Lag|OP18|PP17|PP19|PR22|SMN HGNC:6510|MIM:151442|Ensembl:ENSG00000117632|HPRD:01047|Vega:OTTHUMG00000007389 1 1p36.11 stathmin 1 protein-coding stathmin 1 leukemia-associated phosp Through transcriptome profiling, we identified three novel miR-101 targets, STMN1, RAB5A and ATG4D. siRNA-mediated depletion of these genes phenocopied the effect of miR-101 overexpression, demonstrating their importance in autophagy regulation. 75 miR-101 hsa-miR-101-5p,hsa-miR-101-3p MIMAT0004513,MIMAT0000099 miRNA STMN1 autophagy Homo sapiens HepG2 cell line 23483142 9606 3925 C1orf215|LAP18|Lag|OP18|PP17|PP19|PR22|SMN HGNC:6510|MIM:151442|Ensembl:ENSG00000117632|HPRD:01047|Vega:OTTHUMG00000007389 1 1p36.11 stathmin 1 protein-coding stathmin 1 MiR-101 inhibited autophagy via targets including RAB5A, STMN1 and ATG4D. 76 miR-101 hsa-miR-101-5p,hsa-miR-101-3p MIMAT0004513,MIMAT0000099 miRNA STMN1 autophagy Homo sapiens NPC cells 25607713 9606 3925 C1orf215|LAP18|Lag|OP18|PP17|PP19|PR22|SMN HGNC:6510|MIM:151442|Ensembl:ENSG00000117632|HPRD:01047|Vega:OTTHUMG00000007389 1 1p36.11 stathmin 1 protein-coding stathmin 1 Stathmin-1(STMN1) was additionally verified as a direct functional target of miR-101, which was found to be involved in cell viability, radioresistance and radiation-induced autophagy of NPC cells. 77 miR-101 hsa-miR-101-5p,hsa-miR-101-3p MIMAT0004513,MIMAT0000099 miRNA autophagy Homo sapiens breast cancer cells 22085996 9606 84971 APG4D|AUTL4|APG4-D HGNC:20789|Ensembl:ENSG00000130734|HPRD:07005|MIM:611340|Vega:OTTHUMG00000180582 19 19p13.2 autophagy related 4D, cysteine peptidase protein coding autophagy related 4D, cysteine peptidase MicroRNA-101 is a potent inhibitor of autophagy. 78 miR-101 hsa-miR-101-5p,hsa-miR-101-3p MIMAT0004513,MIMAT0000099 miRNA autophagy Homo sapiens 22342941 9606 In this review, we focus on highlighting the dual functions of miRNAs as either oncogenes (e.g., miRNA-183, miRNA-376b, miRNA-106a, miRNA-221/222, miRNA-31 and miRNA-34c) or tumor suppressors (e.g., miRNA-30a, miRNA-101 and miRNA-9*) via mediating several autophagic signaling pathways in cancer pathogenesis. Taken together, these findings may uncover the regulatory mechanisms of oncogenic and tumor suppressive miRNAs in autophagy, which would provide a better understanding of miRNA-modulated autophagic signaling networks for future cancer therapeutics. 79 miR-101 hsa-miR-101-5p,hsa-miR-101-3p MIMAT0004513,MIMAT0000099 miRNA autophagy Homo sapiens U-2 OS cells 25013866 9606 While the miR-101 could significantly reduce the doxorubicin-induced AVOs and block the autophagy related protein expression in U-2 OS cells. 80 miR-106a hsa-miR-106a-5p,hsa-miR-106a-3p MIMAT0000103,MIMAT0004517 miRNA ATG12 autophagy down Homo sapiens HCT116 23899543 9606 9140 APG12|APG12L|FBR93|HAPG12 HGNC:588|MIM:609608|Ensembl:ENSG00000145782|HPRD:08496|Vega:OTTHUMG00000128889 5 5q21-q22 autophagy related 12 protein-coding autophagy related 12 MiR-106a and miR-106b overexpression inhibited the expression of several other autophagy genes, including ATG12. 81 miR-106a hsa-miR-106a-5p,hsa-miR-106a-3p MIMAT0000103,MIMAT0004517 miRNA autophagy Homo sapiens 22342941 9606 In this review, we focus on highlighting the dual functions of miRNAs as either oncogenes (e.g., miRNA-183, miRNA-376b, miRNA-106a, miRNA-221/222, miRNA-31 and miRNA-34c) or tumor suppressors (e.g., miRNA-30a, miRNA-101 and miRNA-9*) via mediating several autophagic signaling pathways in cancer pathogenesis. Taken together, these findings may uncover the regulatory mechanisms of oncogenic and tumor suppressive miRNAs in autophagy, which would provide a better understanding of miRNA-modulated autophagic signaling networks for future cancer therapeutics. 82 miR-106b hsa-miR-106b-5p,hsa-miR-106b-3p MIMAT0000680,MIMAT0004672 miRNA ATG12 autophagy down Homo sapiens HCT116 23899543 9606 9140 APG12|APG12L|FBR93|HAPG12 HGNC:588|MIM:609608|Ensembl:ENSG00000145782|HPRD:08496|Vega:OTTHUMG00000128889 5 5q21-q22 autophagy related 12 protein-coding autophagy related 12 MiR-106a and miR-106b overexpression inhibited the expression of several other autophagy genes, including ATG12. 83 miR-106b hsa-miR-106b-5p,hsa-miR-106b-3p MIMAT0000680,MIMAT0004672 miRNA ATG16L1 autophagy down Homo sapiens HCT116 23899543 9606 55054 APG16L|ATG16A|ATG16L|IBD10|WDR30 HGNC:21498|MIM:610767|Ensembl:ENSG00000085978|HPRD:16498|Vega:OTTHUMG00000133619 2 2q37.1 autophagy related 16-like 1 (S. cerevisiae) protein-coding autophagy related 16-like 1 (S. cerevisiae) Both miR-106a and miR-106b mimics inhibited starvation-induced autophagy. The miR-106b mimic reduced ATG16L1 protein expression. 84 miR-106b hsa-miR-106b-5p,hsa-miR-106b-3p MIMAT0000680,MIMAT0004672 miRNA ATG16L1 autophagy down Homo sapiens 24036151 9606 55054 APG16L|ATG16A|ATG16L|IBD10|WDR30 HGNC:21498|MIM:610767|Ensembl:ENSG00000085978|HPRD:16498|Vega:OTTHUMG00000133619 2 2q37.1 autophagy related 16-like 1 (S. cerevisiae) protein-coding autophagy related 16-like 1 (S. cerevisiae) Silencing Dicer1, an essential processor of miRs, increased levels of ATG protein and formation of autophagosomes in cells, indicating that miRs regulate autophagy. Luciferase reporter assays indicated that MIR106B and MIR93 targeted ATG16L1 messenger RNA. MIR106B and MIR93 reduced levels of ATG16L1 and autophagy; t 85 miR-106b hsa-miR-106b-5p,hsa-miR-106b-3p MIMAT0000680,MIMAT0004672 miRNA SQSTM1 autophagy up Homo sapiens myeloid 32D cells 22441107 9606 8878 A170|OSIL|PDB3|ZIP3|p60|p62|p62B HGNC:11280|MIM:601530|Ensembl:ENSG00000161011|HPRD:03319|Vega:OTTHUMG00000150643 5 5q35 sequestosome 1 protein-coding sequestosome 1 SQSTM1 (sequestosome 1/p62), a multiple domain protein that acts as a signaling hub, was identified as a key target for these miRNAs. SQSTM1 can interfere with autophagy via binding to the autophagic regulator Atg8/LC3. 86 miR-106b hsa-miR-106b-5p,hsa-miR-106b-3p MIMAT0000680,MIMAT0004672 miRNA ULK1 autophagy down Homo sapiens myoblast cell line cells 22781751 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 MiR-20a and miR-106b negatively regulate autophagy induced by leucine deprivation via suppression of ULK1 expression in C2C12 myoblasts. 87 miR-124 hsa-miR-124-3p,hsa-miR-124-5p MIMAT0000422,MIMAT0004591 miRNA ANTXR2 autophagy down Homo sapiens Jurkat cells 25736362 9606 118429 CMG-2|CMG2|HFS|ISH|JHF HGNC:21732|MIM:608041|Ensembl:ENSG00000163297|HPRD:07452|Vega:OTTHUMG00000151982 4 4q21.21 anthrax toxin receptor 2 protein-coding anthrax toxin receptor 2 ANTXR2 inhibition by miR-124 promoted JNK activation and induced autophagy. 88 miR-124 hsa-miR-124-3p,hsa-miR-124-5p MIMAT0000422,MIMAT0004591 miRNA autophagy Homo sapiens 21293178 9606 MicroRNA enrichment analysis revealed miR-130, 98, 124, 204 and 142 as the putative post-transcriptional regulators of the autophagy-lysosomal pathway genes. 89 miR-130 hsa-miR-96-5p,hsa-miR-96-3p MIMAT0000095,MIMAT0004510 miRNA autophagy Homo sapiens 21293178 9606 MicroRNA enrichment analysis revealed miR-130, 98, 124, 204 and 142 as the putative post-transcriptional regulators of the autophagy-lysosomal pathway genes. 90 miR-130a hsa-miR-130a-3p,hsa-miR-130a-5p MIMAT0000425 ,MIMAT0004593 miRNA ATG16L1 autophagy down Homo sapiens ileal biopsy 24148619 9606 55054 APG16L|ATG16A|ATG16L|IBD10|WDR30 HGNC:21498|MIM:610767|Ensembl:ENSG00000085978|HPRD:16498|Vega:OTTHUMG00000133619 2 2q37.1 autophagy related 16-like 1 (S. cerevisiae) protein-coding autophagy related 16-like 1 (S. cerevisiae) In ileal biopsy samples of patients with CD, there was an inverse correlation between levels of MIR30C and MIR130A and those of ATG5 and ATG16L1, supporting in vitro findings. Inhibition of MIR30C and MIR130A in cultured intestinal epithelial cells and in mouse enterocytes blocked AIEC-induced inhibition of ATG5 and ATG16L1 expression and restored functional autophagy. 91 miR-130a hsa-miR-130a-3p,hsa-miR-130a-5p MIMAT0000425 ,MIMAT0004593 miRNA ATG2B autophagy down Homo sapiens chronic lymphocytic leukemia cell 22350415 9606 55102 C14orf103 HGNC:20187|Ensembl:ENSG00000066739|HPRD:12626|Vega:OTTHUMG00000149933 14 14q32.2 autophagy related 2B protein-coding autophagy related 2B Notably, miR-130a inhibited autophagy by reducing autophagosome formation, an effect mediated by downregulation of the genes ATG2B and DICER1, the latter of which is a major component of the miRNA silencing machinery. 92 miR-130a hsa-miR-130a-3p,hsa-miR-130a-5p MIMAT0000425,MIMAT0004593 miRNA ATG2B autophagy down Homo sapiens 22902544 9606 55102 C14orf103 HGNC:20187|Ensembl:ENSG00000066739|HPRD:12626|Vega:OTTHUMG00000149933 14 14q32.2 autophagy related 2B protein-coding autophagy related 2B Retrieval is a poorly defined event in mammalian cells in which the ATG9-ATG2-ATG18 complex participates and probably recruits lipids and other regulatory proteins to the growing phagophore. miRNAs identified to regulate this step include miR-34a (ATG9) and miR-130a (ATG2) 93 miR-130a hsa-miR-130a-3p,hsa-miR-130a-5p MIMAT0000425 ,MIMAT0004593 miRNA ATG5 autophagy down Homo sapiens ileal biopsy 24148619 9606 9474 APG5|APG5-LIKE|APG5L|ASP|hAPG5 HGNC:589|MIM:604261|Ensembl:ENSG00000057663|HPRD:16051|Vega:OTTHUMG00000016193 6 6q21 autophagy related 5 protein-coding autophagy related 5 In ileal biopsy samples of patients with CD, there was an inverse correlation between levels of MIR30C and MIR130A and those of ATG5 and ATG16L1, supporting in vitro findings. Inhibition of MIR30C and MIR130A in cultured intestinal epithelial cells and in mouse enterocytes blocked AIEC-induced inhibition of ATG5 and ATG16L1 expression and restored functional autophagy. 94 miR-130a hsa-miR-130a-3p,hsa-miR-130a-5p MIMAT0000425 ,MIMAT0004593 miRNA BCL2 autophagy Homo sapiens EPC 24750349 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 In conclusion, miR-130a is important for maintaining normal autophagy levels and promoting the survival of EPC via regulation of Bcl-2 and Beclin1 expression, via Runx3. MiR-130a may be a regulator linking apoptosis and the autophagy of EPC 95 miR-130a hsa-miR-130a-3p,hsa-miR-130a-5p MIMAT0000425 ,MIMAT0004593 miRNA BECN1 autophagy Homo sapiens endothelial progenitor cell 24750349 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related In conclusion, miR-130a is important for maintaining normal autophagy levels and promoting the survival of EPC via regulation of Bcl-2 and Beclin1 expression, via Runx3. MiR-130a may be a regulator linking apoptosis and the autophagy of EPC 96 miR-130a hsa-miR-130a-3p,hsa-miR-130a-5p MIMAT0000425 ,MIMAT0004593 miRNA DICER1 autophagy down Homo sapiens chronic lymphocytic leukemia cell 22350415 9606 23405 DCR1|Dicer|HERNA|MNG1|RMSE2 HGNC:17098|MIM:606241|Ensembl:ENSG00000100697|HPRD:05875|Vega:OTTHUMG00000166134 14 14q32.13 dicer 1, ribonuclease type III protein-coding dicer 1, ribonuclease type III Notably, miR-130a inhibited autophagy by reducing autophagosome formation, an effect mediated by downregulation of the genes ATG2B and DICER1, the latter of which is a major component of the miRNA silencing machinery. 97 miR-130a hsa-miR-130a-3p,hsa-miR-130a-5p MIMAT0000425 ,MIMAT0004593 miRNA RUNX3 autophagy Homo sapiens endothelial progenitor cell 24750349 9606 864 AML2|CBFA3|PEBP2aC HGNC:10473|MIM:600210|Ensembl:ENSG00000020633|HPRD:02565|Vega:OTTHUMG00000003316 1 1p36 runt-related transcription factor 3 protein-coding runt-related transcription factor 3 In conclusion, miR-130a is important for maintaining normal autophagy levels and promoting the survival of EPC via regulation of Bcl-2 and Beclin1 expression, via Runx3. MiR-130a may be a regulator linking apoptosis and the autophagy of EPC 98 miR-137 hsa-miR-137 MIMAT0000429 miRNA BNIP3L autophagy down Homo sapiens 24573672 9606 665 BNIP3a|NIX HGNC:1085|MIM:605368|Ensembl:ENSG00000104765|HPRD:07288|Vega:OTTHUMG00000099433 8 8p21 BCL2/adenovirus E1B 19kDa interacting protein 3-like protein-coding BCL2/adenovirus E1B 19kDa interacting protein 3-like Impaired mitophagy in response to hypoxia caused by miR-137 is reversed by re-expression of FUNDC1 and NIX expression vectors lacking the miR-137 recognition sites at their 3' UTR. 99 miR-142 hsa-miR-142-5p,hsa-miR-142-3p MIMAT0000433,MIMAT0000434 miRNA autophagy Homo sapiens 21293178 9606 MicroRNA enrichment analysis revealed miR-130, 98, 124, 204 and 142 as the putative post-transcriptional regulators of the autophagy-lysosomal pathway genes. 100 miR-142-3p hsa-miR-142-3p MIMAT0000434 miRNA ATG16L1 autophagy down Homo sapiens epithelial cell|Jurkat T cell. 24401604 9606 55054 APG16L|ATG16A|ATG16L|IBD10|WDR30 HGNC:21498|MIM:610767|Ensembl:ENSG00000085978|HPRD:16498|Vega:OTTHUMG00000133619 2 2q37.1 autophagy related 16-like 1 (S. cerevisiae) protein-coding autophagy related 16-like 1 (S. cerevisiae) We further found that specific miRNAs (miR-181a, miR-519a, miR-374a and miR-630), which are critical downstream targets of the p-¦¤Np63¦Á, modulated the protein levels of ATG5, ATG6/BECN1, ATG10, ATG12, ATG16L1 and UVRAG, adding another level of expression control for autophagic pathways in SCC cells upon cisplatin exposure. 101 miR-143 hsa-miR-143-3p,hsa-miR-143-5p MIMAT0000435,MIMAT0004599 miRNA ATG2B autophagy down Homo sapiens NSCLC H1299 cells 25322940 9606 55102 C14orf103 HGNC:20187|Ensembl:ENSG00000066739|HPRD:12626|Vega:OTTHUMG00000149933 14 14q32.2 autophagy related 2B protein-coding autophagy related 2B In the present study, the autophagy gene, autophagy-related 2B (ATG2B), was identified as a novel target of miR-143. The overexpression of miR-143 was able to downregulate the expression of atg2b at the transcriptional and translational levels by direct binding to its 3' untranslated region. 102 miR-143 hsa-miR-143-3p,hsa-miR-143-5p MIMAT0000435,MIMAT0004599 miRNA autophagy Homo sapiens osteosarcoma tumor cells 25576341 9606 The chemoresistance of osteosarcoma tumor cells to doxorubicin is associated with the downregulation of miR-143 expression, activation of ALDH1+CD133+ cells, activation of autophagy, and inhibition of cell death. 103 miR-144 hsa-miR-144-3p,hsa-miR-144-5p MIMAT0000436,MIMAT0004600 miRNA AKT1 autophagy up Homo sapiens heart 25060662 9606 207 AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA HGNC:391|MIM:164730|Ensembl:ENSG00000142208|HPRD:01261|Vega:OTTHUMG00000170795 14 14q32.32 v-akt murine thymoma viral oncogene homolog 1 protein-coding v-akt murine thymoma viral oncogene homolog 1 Going along with this systemic treatment with miR-144 increased P-Akt, P-GSK3¦Â and P-p44/42 MAPK, decreased p-mTOR level and induced autophagy signaling, and induced early and delayed cardioprotection with improved functional recovery and reduction in infarct size similar to that achieved by rIPC. 104 miR-144 hsa-miR-144-3p,hsa-miR-144-5p MIMAT0000436,MIMAT0004600 miRNA ATG4A autophagy down Homo sapiens RAW264.7 cells 25652854 9606 115201 APG4A|AUTL2 HGNC:16489|MIM:300663|Ensembl:ENSG00000101844|HPRD:06455|Vega:OTTHUMG00000022176 X Xq22.1-q22.3 autophagy related 4A, cysteine peptidase protein-coding autophagy related 4A, cysteine peptidase Conclusion miR-144 can directly inhibit the autophagy-related gene Atg4a expression and participate in the regulation of autophagy process in Mycobacterium tuberculosis infection 105 miR-144 hsa-miR-144-3p,hsa-miR-144-5p MIMAT0000436,MIMAT0004600 miRNA C12orf5 autophagy Homo sapiens lung cancer cell 25660220 9606 57103 FR2BP|TIGAR HGNC:1185|MIM:610775|HPRD:12610 12 12p13.3 chromosome 12 open reading frame 5 protein-coding chromosome 12 open reading frame 5 MiR-144 Inhibits Proliferation and Induces Apoptosis and Autophagy in Lung Cancer Cells by Targeting TIGAR. 106 miR-144 hsa-miR-144-3p,hsa-miR-144-5p MIMAT0000436,MIMAT0004600 miRNA GSK3B autophagy up Homo sapiens heart 25060662 9606 2932 - HGNC:4617|MIM:605004|Ensembl:ENSG00000082701|HPRD:05418|Vega:OTTHUMG00000133765 3 3q13.3 glycogen synthase kinase 3 beta protein-coding glycogen synthase kinase 3 beta Going along with this systemic treatment with miR-144 increased P-Akt, P-GSK3¦Â and P-p44/42 MAPK, decreased p-mTOR level and induced autophagy signaling, and induced early and delayed cardioprotection with improved functional recovery and reduction in infarct size similar to that achieved by rIPC. 107 miR-144 hsa-miR-144-3p,hsa-miR-144-5p MIMAT0000436,MIMAT0004600 miRNA MAPK1 autophagy up Homo sapiens heart 25060662 9606 5594 ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK HGNC:6871|MIM:176948|Ensembl:ENSG00000100030|HPRD:01496|Vega:OTTHUMG00000030508 22 22q11.21 mitogen-activated protein kinase 1 protein-coding mitogen-activated protein kinase 1 Going along with this systemic treatment with miR-144 increased P-Akt, P-GSK3¦Â and P-p44/42 MAPK, decreased p-mTOR level and induced autophagy signaling, and induced early and delayed cardioprotection with improved functional recovery and reduction in infarct size similar to that achieved by rIPC. 108 miR-144 hsa-miR-144-3p,hsa-miR-144-5p MIMAT0000436,MIMAT0004600 miRNA MAPK3 autophagy up Homo sapiens heart 25060662 9606 5595 ERK-1|ERK1|ERT2|HS44KDAP|HUMKER1A|P44ERK1|P44MAPK|PRKM3|p44-ERK1|p44-MAPK HGNC:6877|MIM:601795|Ensembl:ENSG00000102882|HPRD:03479|Vega:OTTHUMG00000132149 16 16p11.2 mitogen-activated protein kinase 3 protein-coding mitogen-activated protein kinase 3 Going along with this systemic treatment with miR-144 increased P-Akt, P-GSK3¦Â and P-p44/42 MAPK, decreased p-mTOR level and induced autophagy signaling, and induced early and delayed cardioprotection with improved functional recovery and reduction in infarct size similar to that achieved by rIPC. 109 miR-144 hsa-miR-144-3p,hsa-miR-144-5p MIMAT0000436,MIMAT0004600 miRNA MTOR autophagy down Homo sapiens heart 25060662 9606 2475 FRAP|FRAP1|FRAP2|RAFT1|RAPT1 HGNC:3942|MIM:601231|Ensembl:ENSG00000198793|HPRD:03134|Vega:OTTHUMG00000002001 1 1p36.2 mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) Going along with this systemic treatment with miR-144 increased P-Akt, P-GSK3¦Â and P-p44/42 MAPK, decreased p-mTOR level and induced autophagy signaling, and induced early and delayed cardioprotection with improved functional recovery and reduction in infarct size similar to that achieved by rIPC. 110 miR-152 hsa-miR-152-3p,hsa-miR-152-5p MIMAT0000438,MIMAT0026479 miRNA ATG14 autophagy down Homo sapiens ovarian cancer cell 25650716 9606 22863 ATG14L|BARKOR|KIAA0831 HGNC:19962|MIM:613515|Ensembl:ENSG00000126775|HPRD:13820|Vega:OTTHUMG00000172129 14 14q22.3 autophagy related 14 protein-coding autophagy related 14 Downregulation of ATG14 by EGR1-MIR152 sensitizes ovarian cancer cells to cisplatin-induced apoptosis by inhibiting cyto-protective autophagy. 111 miR-152 hsa-miR-152-3p,hsa-miR-152-5p MIMAT0000438,MIMAT0026479 miRNA COPZ2 autophagy Homo sapiens 21746916 9606 51226 zeta2-COP HGNC:19356|MIM:615526|Ensembl:ENSG00000005243|HPRD:16739 17 17q21.32 coatomer protein complex, subunit zeta 2 protein-coding coatomer protein complex, subunit zeta 2 COPZ2 displays no tumor-suppressive activities, but it harbors microRNA 152, which is silenced in tumor cells concurrently with COPZ2 and acts as a tumor suppressor in vitro and in vivo. 112 miR-155 hsa-miR-155-5p,hsa-miR-155-3p MIMAT0000646,MIMAT0004658 miRNA ATG7 autophagy down Homo sapiens 24130493 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 Furthermore, blocking autophagy with specific inhibitor 3-methyladenine or silencing of autophagy related gene 7 (Atg7) reduced the ability of miR-155 to promote autophagy and mycobacterial elimination. More importantly, our study demonstrated that miR-155 bound to the 3'-untranslated region of Ras homologue enriched in brain (Rheb), a negative regulator of autophagy, accelerated the process of autophagy and sequential killing of intracellular mycobacteria by suppressing Rheb expression. 113 miR-155 hsa-miR-155-5p,hsa-miR-155-3p MIMAT0000646,MIMAT0004658 miRNA GSK3B autophagy down Homo sapiens 24343269 9606 2932 - HGNC:4617|MIM:605004|Ensembl:ENSG00000082701|HPRD:05418|Vega:OTTHUMG00000133765 3 3q13.3 glycogen synthase kinase 3 beta protein-coding glycogen synthase kinase 3 beta Importantly, cellular levels of PP2A, a phosphatase, were regulated by Mir155 and Mir31 to fine-tune autophagy. Diminished expression of PP2A led to inhibition of GSK3B, thus facilitating the prolonged activation of WNT and SHH signaling pathways. Sustained WNT and SHH signaling effectuated the expression of anti-inflammatory lipoxygenases, which in tandem inhibited IFNG-induced JAK-STAT signaling and contributed to evasion of autophagy. 114 miR-155 hsa-miR-155-5p,hsa-miR-155-3p MIMAT0000646,MIMAT0004658 miRNA PPP2R4 autophagy down Homo sapiens 24343269 9606 5524 PP2A|PR53|PTPA HGNC:9308|MIM:600756|Ensembl:ENSG00000119383|HPRD:02858|Vega:OTTHUMG00000020774 9 9q34 protein phosphatase 2A activator, regulatory subunit 4 protein-coding protein phosphatase 2A activator, regulatory subunit 4 Importantly, cellular levels of PP2A, a phosphatase, were regulated by Mir155 and Mir31 to fine-tune autophagy. Diminished expression of PP2A led to inhibition of GSK3B, thus facilitating the prolonged activation of WNT and SHH signaling pathways. Sustained WNT and SHH signaling effectuated the expression of anti-inflammatory lipoxygenases, which in tandem inhibited IFNG-induced JAK-STAT signaling and contributed to evasion of autophagy. 115 miR-155 hsa-miR-155-5p,hsa-miR-155-3p MIMAT0000646,MIMAT0004658 miRNA RHEB autophagy down Homo sapiens brain 24130493 9606 6009 RHEB2 HGNC:10011|MIM:601293|Ensembl:ENSG00000106615|HPRD:03188|Vega:OTTHUMG00000157330 7 7q36 Ras homolog enriched in brain protein-coding Ras homolog enriched in brain Furthermore, blocking autophagy with specific inhibitor 3-methyladenine or silencing of autophagy related gene 7 (Atg7) reduced the ability of miR-155 to promote autophagy and mycobacterial elimination. More importantly, our study demonstrated that miR-155 bound to the 3'-untranslated region of Ras homologue enriched in brain (Rheb), a negative regulator of autophagy, accelerated the process of autophagy and sequential killing of intracellular mycobacteria by suppressing Rheb expression. 116 miR-155 hsa-miR-155-5p,hsa-miR-155-3p MIMAT0000646,MIMAT0000646 miRNA RHEB autophagy down Homo sapiens asopharyngeal cancer and cervical cancer cell 24262949 9606 6009 RHEB2 HGNC:10011|MIM:601293|Ensembl:ENSG00000106615|HPRD:03188|Vega:OTTHUMG00000157330 7 7q36 Ras homolog enriched in brain protein-coding Ras homolog enriched in brain Enforced expression of MIR155 increases autophagic activity in human nasopharyngeal cancer and cervical cancer cells. Knocking down endogenous MIR155 inhibits hypoxia-induced autophagy. We demonstrated that MIR155 targets multiple players in MTOR signaling, including RHEB, RICTOR, and RPS6KB2. MIR155 suppresses target-gene expression by directly interacting with their 3' untranslated regions (UTRs), mutations of the binding sites abolish their MIR155 responsiveness. 117 miR-155 hsa-miR-155-5p,hsa-miR-155-3p MIMAT0004658,MIMAT0000646 miRNA RICTOR autophagy down Homo sapiens asopharyngeal cancer and cervical cancer cell 24262949 9606 253260 AVO3|PIA|hAVO3 HGNC:28611|MIM:609022|Ensembl:ENSG00000164327|HPRD:10682|Vega:OTTHUMG00000162037 5 5p13.1 RPTOR independent companion of MTOR, complex 2 protein-coding RPTOR independent companion of MTOR, complex 2 Enforced expression of MIR155 increases autophagic activity in human nasopharyngeal cancer and cervical cancer cells. Knocking down endogenous MIR155 inhibits hypoxia-induced autophagy. We demonstrated that MIR155 targets multiple players in MTOR signaling, including RHEB, RICTOR, and RPS6KB2. MIR155 suppresses target-gene expression by directly interacting with their 3' untranslated regions (UTRs), mutations of the binding sites abolish their MIR155 responsiveness. 118 miR-155 hsa-miR-155-5p,hsa-miR-155-3p MIMAT0000646,MIMAT0000646 miRNA RPS6KB2 autophagy down Homo sapiens asopharyngeal cancer and cervical cancer cell 24262949 9606 6199 KLS|P70-beta|P70-beta-1|P70-beta-2|S6K-beta2|S6K2|SRK|STK14B|p70(S6K)-beta|p70S6Kb HGNC:10437|MIM:608939|Ensembl:ENSG00000175634|HPRD:10203|Vega:OTTHUMG00000167673 11 11q13.2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 protein-coding ribosomal protein S6 kinase, 70kDa, polypeptide 2 Enforced expression of MIR155 increases autophagic activity in human nasopharyngeal cancer and cervical cancer cells. Knocking down endogenous MIR155 inhibits hypoxia-induced autophagy. We demonstrated that MIR155 targets multiple players in MTOR signaling, including RHEB, RICTOR, and RPS6KB2. MIR155 suppresses target-gene expression by directly interacting with their 3' untranslated regions (UTRs), mutations of the binding sites abolish their MIR155 responsiveness. 119 miR-16 hsa-miR-16-5p,hsa-miR-16-1-3p,hsa-miR-16-2-3p MIMAT0000069,MIMAT0004489,MIMAT0004518 miRNA ATG5 autophagy down Homo sapiens HeLa cell 23143396 9606 9474 APG5|APG5-LIKE|APG5L|ASP|hAPG5 HGNC:589|MIM:604261|Ensembl:ENSG00000057663|HPRD:16051|Vega:OTTHUMG00000016193 6 6q21 autophagy related 5 protein-coding autophagy related 5 Levels of miR-16 and let-7a, measured by Northern blot or RT-qPCR, indeed decreased significantly in cells treated with siRNAs targeting NDP52, ATG5 or ATG7, but not p62, for an extended period of 4 days (Fig.4a-b). In contrast, pre-miR-16 and pre-let-7a levels were not overtly modified (Fig.4a-c) suggesting that prolonged defects in autophagy specifically affect miRNA stability after pre-miRNA processing, but before miRISC formation and activity. 120 miR-16 hsa-miR-16-5p,hsa-miR-16-1-3p,hsa-miR-16-2-3p MIMAT0000069,MIMAT0004489,MIMAT0004518 miRNA ATG7 autophagy down Homo sapiens HeLa cell 23143396 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 Levels of miR-16 and let-7a, measured by Northern blot or RT-qPCR, indeed decreased significantly in cells treated with siRNAs targeting NDP52, ATG5 or ATG7, but not p62, for an extended period of 4 days (Fig.4a-b). In contrast, pre-miR-16 and pre-let-7a levels were not overtly modified (Fig.4a-c) suggesting that prolonged defects in autophagy specifically affect miRNA stability after pre-miRNA processing, but before miRISC formation and activity. 121 miR-16 hsa-miR-16-5p,hsa-miR-16-1-3p,hsa-miR-16-2-3p MIMAT0000069,MIMAT0004489,MIMAT0004518 miRNA CALCOCO2 autophagy down Homo sapiens HeLa cell 23143396 9606 10241 NDP52 HGNC:29912|MIM:604587|Ensembl:ENSG00000136436|HPRD:06846|Vega:OTTHUMG00000160505 17 17q21.32 calcium binding and coiled-coil domain 2 protein-coding calcium binding and coiled-coil domain 2 Levels of miR-16 and let-7a, measured by Northern blot or RT-qPCR, indeed decreased significantly in cells treated with siRNAs targeting NDP52, ATG5 or ATG7, but not p62, for an extended period of 4 days (Fig.4a-b). In contrast, pre-miR-16 and pre-let-7a levels were not overtly modified (Fig.4a-c) suggesting that prolonged defects in autophagy specifically affect miRNA stability after pre-miRNA processing, but before miRISC formation and activity. 122 miR-17 hsa-miR-17-5p,hsa-miR-17-3p MIMAT0000070,MIMAT0000071 miRNA ATG7 autophagy down Homo sapiens glioblastoma cells 23792642 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 We demonstrated that ATG7 is a potential target for miR-17, and this miRNA could negatively regulate ATG7 expression, resulting in a modulation of the autophagic status in T98G glioblastoma cells. 123 miR-17 hsa-miR-17-5p,hsa-miR-17-3p MIMAT0000070,MIMAT0000071 miRNA ATG7 autophagy down Homo sapiens hepatocellular carcinoma 25617127 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 The overexpressed PTENP1 decoyed oncomirs miR-17, miR-19b and miR-20a, which would otherwise target PTEN, PHLPP (a negative AKT regulator) and such autophagy genes as ULK1, ATG7 and p62, indicating that PTENP1 modulated the HCC cell behavior and gene networks by miRNA regulation. 124 miR-17 hsa-miR-17-5p,hsa-miR-17-3p MIMAT0000070,MIMAT0000071 miRNA SQSTM1 autophagy up Homo sapiens myeloid 32D cells 22441107 9606 8878 A170|OSIL|PDB3|ZIP3|p60|p62|p62B HGNC:11280|MIM:601530|Ensembl:ENSG00000161011|HPRD:03319|Vega:OTTHUMG00000150643 5 5q35 sequestosome 1 protein-coding sequestosome 1 SQSTM1 (sequestosome 1/p62), a multiple domain protein that acts as a signaling hub, was identified as a key target for these miRNAs. SQSTM1 can interfere with autophagy via binding to the autophagic regulator Atg8/LC3. 125 miR-17 hsa-miR-17-5p,hsa-miR-17-3p MIMAT0000070,MIMAT0000071 miRNA SQSTM1 autophagy down Homo sapiens hepatocellular carcinoma 25617127 9606 8878 A170|OSIL|PDB3|ZIP3|p60|p62|p62B HGNC:11280|MIM:601530|Ensembl:ENSG00000161011|HPRD:03319|Vega:OTTHUMG00000150643 5 5q35 sequestosome 1 protein-coding sequestosome 1 The overexpressed PTENP1 decoyed oncomirs miR-17, miR-19b and miR-20a, which would otherwise target PTEN, PHLPP (a negative AKT regulator) and such autophagy genes as ULK1, ATG7 and p62, indicating that PTENP1 modulated the HCC cell behavior and gene networks by miRNA regulation. 126 miR-17 hsa-miR-17-5p,hsa-miR-17-3p MIMAT0000070,MIMAT0000071 miRNA ULK1 autophagy down Homo sapiens hepatocellular carcinoma 25617127 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 The overexpressed PTENP1 decoyed oncomirs miR-17, miR-19b and miR-20a, which would otherwise target PTEN, PHLPP (a negative AKT regulator) and such autophagy genes as ULK1, ATG7 and p62, indicating that PTENP1 modulated the HCC cell behavior and gene networks by miRNA regulation. 127 miR-181a hsa-miR-181a-5p,hsa-miR-181a-3p,hsa-miR-181a-2-3p MIMAT0000256,MIMAT0000270,MIMAT0004558 miRNA ATG10 autophagy Homo sapiens squamous cell carcinoma cell 22356768 9606 83734 APG10|APG10L|pp12616 HGNC:20315|MIM:610800|Ensembl:ENSG00000152348|HPRD:16497|Vega:OTTHUMG00000119041 5 5q14.1 autophagy related 10 protein-coding autophagy related 10 We further found that specific miRNAs (miR-181a, miR-519a, miR-374a and miR-630), which are critical downstream targets of the p-¦¤Np63¦Á, modulated the protein levels of ATG5, ATG6/BECN1, ATG10, ATG12, ATG16L1 and UVRAG, adding another level of expression control for autophagic pathways in SCC cells upon cisplatin exposure. 128 miR-181a hsa-miR-181a-5p,hsa-miR-181a-2-3p,hsa-miR-181a-3p MIMAT0000270,MIMAT0004558,MIMAT0000256 miRNA ATG12 autophagy Homo sapiens squamous cell carcinoma cell 22356768 9606 9140 APG12|APG12L|FBR93|HAPG12 HGNC:588|MIM:609608|Ensembl:ENSG00000145782|HPRD:08496|Vega:OTTHUMG00000128889 5 5q21-q22 autophagy related 12 protein-coding autophagy related 12 We further found that specific miRNAs (miR-181a, miR-519a, miR-374a and miR-630), which are critical downstream targets of the p-¦¤Np63¦Á, modulated the protein levels of ATG5, ATG6/BECN1, ATG10, ATG12, ATG16L1 and UVRAG, adding another level of expression control for autophagic pathways in SCC cells upon cisplatin exposure. 129 miR-181a hsa-miR-181a-5p,hsa-miR-181a-2-3p,hsa-miR-181a-3p MIMAT0000270,MIMAT0004558,MIMAT0000256 miRNA ATG16L1 autophagy Homo sapiens squamous cell carcinoma cell 22356768 9606 55054 APG16L|ATG16A|ATG16L|IBD10|WDR30 HGNC:21498|MIM:610767|Ensembl:ENSG00000085978|HPRD:16498|Vega:OTTHUMG00000133619 2 2q37.1 autophagy related 16-like 1 (S. cerevisiae) protein-coding autophagy related 16-like 1 (S. cerevisiae) We further found that specific miRNAs (miR-181a, miR-519a, miR-374a and miR-630), which are critical downstream targets of the p-¦¤Np63¦Á, modulated the protein levels of ATG5, ATG6/BECN1, ATG10, ATG12, ATG16L1 and UVRAG, adding another level of expression control for autophagic pathways in SCC cells upon cisplatin exposure. 130 miR-181a hsa-miR-181a-5p,hsa-miR-181a-2-3p,hsa-miR-181a-3p MIMAT0000270,MIMAT0004558,MIMAT0000256 miRNA ATG5 autophagy Homo sapiens squamous cell carcinoma cell 22356768 9606 9474 APG5|APG5-LIKE|APG5L|ASP|hAPG5 HGNC:589|MIM:604261|Ensembl:ENSG00000057663|HPRD:16051|Vega:OTTHUMG00000016193 6 6q21 autophagy related 5 protein-coding autophagy related 5 We further found that specific miRNAs (miR-181a, miR-519a, miR-374a and miR-630), which are critical downstream targets of the p-¦¤Np63¦Á, modulated the protein levels of ATG5, ATG6/BECN1, ATG10, ATG12, ATG16L1 and UVRAG, adding another level of expression control for autophagic pathways in SCC cells upon cisplatin exposure. 131 miR-181a hsa-miR-181a-5p,hsa-miR-181a-3p,hsa-miR-181a-2-3p MIMAT0000256,MIMAT0000270,MIMAT0004558 miRNA ATG5 autophagy down Homo sapiens 22902544 9606 9474 APG5|APG5-LIKE|APG5L|ASP|hAPG5 HGNC:589|MIM:604261|Ensembl:ENSG00000057663|HPRD:16051|Vega:OTTHUMG00000016193 6 6q21 autophagy related 5 protein-coding autophagy related 5 ATG5-ATG12 forms a large multimeric complex with ATG16, which functions as the E3 ligase for LC3. Several miRNA regulators of this step have been identified including miR-30a, miR-181a and miR-374a (ATG5), miR-630 (ATG12), miR-376b (ATG4), miR-204 (LC3), miR-375 (ATG7), miR-519a (ATG10 and ATG16), miR-885-3p (ATG16) and miR-101 (ATG4 and RAB5A). 132 miR-181a hsa-miR-181a-5p,hsa-miR-181a-2-3p,hsa-miR-181a-3p MIMAT0000270,MIMAT0004558,MIMAT0000256 miRNA ATG5 autophagy down Homo sapiens MCF-7/Huh-7/K562 cell 23322078 9606 9474 APG5|APG5-LIKE|APG5L|ASP|hAPG5 HGNC:589|MIM:604261|Ensembl:ENSG00000057663|HPRD:16051|Vega:OTTHUMG00000016193 6 6q21 autophagy related 5 protein-coding autophagy related 5 We further found that specific miRNAs (miR-181a, miR-519a, miR-374a and miR-630), which are critical downstream targets of the p-¦¤Np63¦Á, modulated the protein levels of ATG5, ATG6/BECN1, ATG10, ATG12, ATG16L1 and UVRAG, adding another level of expression control for autophagic pathways in SCC cells upon cisplatin exposure. 133 miR-181a hsa-miR-181a-5p,hsa-miR-181a-3p,hsa-miR-181a-2-3p MIMAT0000256,MIMAT0000270,MIMAT0004558 miRNA BECN1 autophagy Homo sapiens squamous cell carcinoma cell 22356768 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related We further found that specific miRNAs (miR-181a, miR-519a, miR-374a and miR-630), which are critical downstream targets of the p-¦¤Np63¦Á, modulated the protein levels of ATG5, ATG6/BECN1, ATG10, ATG12, ATG16L1 and UVRAG, adding another level of expression control for autophagic pathways in SCC cells upon cisplatin exposure. 134 miR-181a hsa-miR-181a-5p,hsa-miR-181a-3p,hsa-miR-181a-2-3p MIMAT0000256,MIMAT0000270,MIMAT0004558 miRNA TP63 autophagy down Homo sapiens squamous cell carcinoma cell 22356768 9606 8626 AIS|B(p51A)|B(p51B)|EEC3|KET|LMS|NBP|OFC8|RHS|SHFM4|TP53CP|TP53L|TP73L|p40|p51|p53CP|p63|p73H|p73L HGNC:15979|MIM:603273|Ensembl:ENSG00000073282|HPRD:04469|Vega:OTTHUMG00000156313 3 3q28 tumor protein p63 protein-coding tumor protein p63 We further found that specific miRNAs (miR-181a, miR-519a, miR-374a and miR-630), which are critical downstream targets of the p-¦¤Np63¦Á, modulated the protein levels of ATG5, ATG6/BECN1, ATG10, ATG12, ATG16L1 and UVRAG, adding another level of expression control for autophagic pathways in SCC cells upon cisplatin exposure. 135 miR-181a hsa-miR-181a-5p,hsa-miR-181a-3p,hsa-miR-181a-2-3p MIMAT0000256,MIMAT0000270,MIMAT0004558 miRNA UVRAG autophagy Homo sapiens squamous cell carcinoma cell 22356768 9606 7405 DHTX|VPS38|p63 HGNC:12640|MIM:602493|HPRD:03929 11 11q13.5 UV radiation resistance associated protein-coding UV radiation resistance associated We further found that specific miRNAs (miR-181a, miR-519a, miR-374a and miR-630), which are critical downstream targets of the p-¦¤Np63¦Á, modulated the protein levels of ATG5, ATG6/BECN1, ATG10, ATG12, ATG16L1 and UVRAG, adding another level of expression control for autophagic pathways in SCC cells upon cisplatin exposure. 136 miR-182 hsa-miR-182-5p,hsa-miR-182-3p MIMAT0000259,MIMAT0000260 miRNA BCL2 autophagy down Homo sapiens prostate cancer cell 23936432 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 miR-182 expression in PC3 cells was also increased in response to stress induced by serum withdrawal, suggesting that miR-182 upregulation can occur due to nutritional stress. Bcl2 and p21 were identified to be potential target genes of miR-182 in PC3 cells. 137 miR-182 hsa-miR-182-5p,hsa-miR-182-3p MIMAT0000259,MIMAT0000260 miRNA CDKN1A autophagy down Homo sapiens PC3 23936432 9606 1026 CAP20|CDKN1|CIP1|MDA-6|P21|SDI1|WAF1|p21CIP1 HGNC:1784|MIM:116899|Ensembl:ENSG00000124762|HPRD:00298|Vega:OTTHUMG00000014603 6 6p21.2 cyclin-dependent kinase inhibitor 1A (p21, Cip1) protein-coding cyclin-dependent kinase inhibitor 1A (p21, Cip1) miR-182 expression in PC3 cells was also increased in response to stress induced by serum withdrawal, suggesting that miR-182 upregulation can occur due to nutritional stress. Bcl2 and p21 were identified to be potential target genes of miR-182 in PC3 cells. 138 miR-183 hsa-miR-183-5p,hsa-miR-183-3p MIMAT0000261,MIMAT0004560 miRNA autophagy Homo sapiens 22342941 9606 In this review, we focus on highlighting the dual functions of miRNAs as either oncogenes (e.g., miRNA-183, miRNA-376b, miRNA-106a, miRNA-221/222, miRNA-31 and miRNA-34c) or tumor suppressors (e.g., miRNA-30a, miRNA-101 and miRNA-9*) via mediating several autophagic signaling pathways in cancer pathogenesis. Taken together, these findings may uncover the regulatory mechanisms of oncogenic and tumor suppressive miRNAs in autophagy, which would provide a better understanding of miRNA-modulated autophagic signaling networks for future cancer therapeutics. 139 miR-18a hsa-miR-18a-5p,hsa-miR-18a-3p MIMAT0000072,MIMAT0002891 miRNA ATM autophagy up Homo sapiens colon cancer cells 23229340 9606 472 AT1|ATA|ATC|ATD|ATDC|ATE|TEL1|TELO1 HGNC:795|MIM:607585|Ensembl:ENSG00000149311|HPRD:06347|Vega:OTTHUMG00000166480 11 11q22-q23 ATM serine/threonine kinase protein-coding ATM serine/threonine kinase MicroRNA-18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells.Results of the present study pertaining to the role of miR-18a in regulating autophagy and ATM gene expression in colon cancer cells revealed a novel function for miR-18a in a critical cellular event and on a crucial gene with significant impacts in cancer development, progression, treatment and in other diseases. 140 miR-191 hsa-miR-191-5p,hsa-miR-191-3p MIMAT0000440,MIMAT0001618 miRNA BECN1 autophagy up Homo sapiens lung cancer cell 25685068 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related Increased Beclin-1, LC3-II and decreased p62 have been observed in radiation-resistant cells indicating elevated autophagy level. Decreased miR-191 in radiation-resistant cells performed by Taqman qRT-PCR also has been seen. Two binding sites between Beclin-1 and miR-191 suggest potential association between. 141 miR-195 hsa-miR-195-5p,hsa-miR-195-3p MIMAT0000461,MIMAT0004615 miRNA ATG14 autophagy Homo sapiens peripheral nerve cell 23361941 9606 22863 ATG14L|BARKOR|KIAA0831 HGNC:19962|MIM:613515|Ensembl:ENSG00000126775|HPRD:13820|Vega:OTTHUMG00000172129 14 14q22.3 autophagy related 14 protein-coding autophagy related 14 We further demonstrated that PNI significantly inhibited microglial autophagy activation, whereas miR-195 inhibitor treatment increased autophagy activation and suppressed neuroinflammation in vivo and in vitro. More important, autophagy inhibition impaired miR-195 inhibitor-induced downregulation of neuroinflammation and neuropathic pain. Additionally, ATG14 was identified as the functional target of miR-195. 142 miR-199a-5p hsa-miR-199a-5p MIMAT0000231 miRNA ATG7 autophagy Homo sapiens hepatocellular carcinoma cell 22713463 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 We further demonstrated that downregulated miR-199a-5p enhanced autophagy activation by targeting autophagy-associated gene 7 (ATG7). More important, autophagy inhibition abrogated miR-199a-5p downregulation-induced cell proliferation. 143 miR-199a-5p hsa-miR-199a-5p MIMAT0000231 miRNA BECN1 autophagy down Homo sapiens breast cancer cell. 23337876 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related Overexpression of miR-199a-5p inhibits DRAM1 and Beclin1 expression in MCF7 cells, while it enhances expression of these genes in MDA-MB-231 cells. 144 miR-199a-5p hsa-miR-199a-5p MIMAT0000231 miRNA DRAM1 autophagy down Homo sapiens breast cancer cell. 23337876 9606 55332 DRAM HGNC:25645|MIM:610776|Ensembl:ENSG00000136048|HPRD:07743|Vega:OTTHUMG00000170447 12 12q23.2 DNA-damage regulated autophagy modulator 1 protein-coding DNA-damage regulated autophagy modulator 1 Overexpression of miR-199a-5p inhibits DRAM1 and Beclin1 expression in MCF7 cells, while it enhances expression of these genes in MDA-MB-231 cells. 145 miR-19b hsa-miR-19b-3p MIMAT0000074 miRNA ATG7 autophagy down Homo sapiens hepatocellular carcinoma 25617127 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 The overexpressed PTENP1 decoyed oncomirs miR-17, miR-19b and miR-20a, which would otherwise target PTEN, PHLPP (a negative AKT regulator) and such autophagy genes as ULK1, ATG7 and p62, indicating that PTENP1 modulated the HCC cell behavior and gene networks by miRNA regulation. 146 miR-19b hsa-miR-19b-3p MIMAT0000074 miRNA SQSTM1 autophagy down Homo sapiens hepatocellular carcinoma 25617127 9606 8878 A170|OSIL|PDB3|ZIP3|p60|p62|p62B HGNC:11280|MIM:601530|Ensembl:ENSG00000161011|HPRD:03319|Vega:OTTHUMG00000150643 5 5q35 sequestosome 1 protein-coding sequestosome 1 The overexpressed PTENP1 decoyed oncomirs miR-17, miR-19b and miR-20a, which would otherwise target PTEN, PHLPP (a negative AKT regulator) and such autophagy genes as ULK1, ATG7 and p62, indicating that PTENP1 modulated the HCC cell behavior and gene networks by miRNA regulation. 147 miR-19b hsa-miR-19b-3p MIMAT0000074 miRNA ULK1 autophagy down Homo sapiens hepatocellular carcinoma 25617127 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 The overexpressed PTENP1 decoyed oncomirs miR-17, miR-19b and miR-20a, which would otherwise target PTEN, PHLPP (a negative AKT regulator) and such autophagy genes as ULK1, ATG7 and p62, indicating that PTENP1 modulated the HCC cell behavior and gene networks by miRNA regulation. 148 miR-20 hsa-miR-20a-3p,hsa-miR-20b-3p MIMAT0004493,MIMAT0004752 miRNA SQSTM1 autophagy up Homo sapiens myeloid 32D cells 22441107 9606 8878 A170|OSIL|PDB3|ZIP3|p60|p62|p62B HGNC:11280|MIM:601530|Ensembl:ENSG00000161011|HPRD:03319|Vega:OTTHUMG00000150643 5 5q35 sequestosome 1 protein-coding sequestosome 1 SQSTM1 (sequestosome 1/p62), a multiple domain protein that acts as a signaling hub, was identified as a key target for these miRNAs. SQSTM1 can interfere with autophagy via binding to the autophagic regulator Atg8/LC3. 149 miR-200c hsa-miR-200c-3p,hsa-miR-200c-5p MIMAT0000617,MIMAT0004657 miRNA UBQLN1 autophagy down Homo sapiens breast cancer cell 25044403 9606 29979 DA41|DSK2|PLIC-1|UBQN|XDRP1 HGNC:12508|MIM:605046|Ensembl:ENSG00000135018|HPRD:05440|Vega:OTTHUMG00000020104 9 9q22|9q21.2-q21.3 ubiquilin 1 protein-coding ubiquilin 1 MiR-200c inhibits autophagy and enhances radiosensitivity in breast cancer cells by targeting UBQLN1. 150 miR-204 hsa-miR-204-5p,hsa-miR-204-3p MIMAT0000265,MIMAT0022693 miRNA CAV1 autophagy up Homo sapiens renal cell carcinoma 25517751 9606 857 BSCL3|CGL3|LCCNS|MSTP085|PPH3|VIP21 HGNC:1527|MIM:601047|Ensembl:ENSG00000105974|HPRD:03028|Vega:OTTHUMG00000023413 7 7q31.1 caveolin 1, caveolae protein, 22kDa protein-coding caveolin 1, caveolae protein, 22kDa The von Hippel-Lindau tumor suppressor (VHL) represses TRPM3 directly through miR-204 and indirectly through another miR-204 target, Caveolin 1 (CAV1). 151 miR-204 hsa-miR-204-5p,hsa-miR-204-3p MIMAT0000265,MIMAT0022693 miRNA MAP1LC3B autophagy down Homo sapiens cardiomyocyte 21631941 9606 81631 ATG8F|LC3B|MAP1A/1BLC3|MAP1LC3B-a HGNC:13352|MIM:609604|Ensembl:ENSG00000140941|HPRD:14358|Vega:OTTHUMG00000137654 16 16q24.2 microtubule-associated protein 1 light chain 3 beta protein-coding microtubule-associated protein 1 light chain 3 beta We found that IR induced cardiomyocytes autophagy, together with down-regulation of miR-204 and up-regulation of LC3-II protein. And, we have found that LC3-II protein was regulated by miR-204, using the method of transferring miR-204 mimic or AMO-204 into the cardiomyocytes, before. 152 miR-204 hsa-miR-204-5p,hsa-miR-204-3p MIMAT0000265,MIMAT0022693 miRNA TRPM3 autophagy down Homo sapiens renal cell carcinoma 25517751 9606 80036 GON-2|LTRPC3|MLSN2 HGNC:17992|MIM:608961|Ensembl:ENSG00000083067|HPRD:10605|Vega:OTTHUMG00000019997 9 9q21.12 transient receptor potential cation channel, subfamily M, member 3 protein-coding transient receptor potential cation channel, subfamily M, member 3 The von Hippel-Lindau tumor suppressor (VHL) represses TRPM3 directly through miR-204 and indirectly through another miR-204 target, Caveolin 1 (CAV1). 153 miR-204 hsa-miR-204-5p,hsa-miR-204-3p MIMAT0000265,MIMAT0022693 miRNA VHL autophagy down Homo sapiens renal cell carcinoma 25517751 9606 7428 HRCA1|RCA1|VHL1|pVHL HGNC:12687|MIM:608537|HPRD:01905 3 3p25.3 von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase protein-coding von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase The von Hippel-Lindau tumor suppressor (VHL) represses TRPM3 directly through miR-204 and indirectly through another miR-204 target, Caveolin 1 (CAV1). 154 miR-204 hsa-miR-204-5p,hsa-miR-204-3p MIMAT0000265,MIMAT0022693 miRNA autophagy Homo sapiens 21293178 9606 MicroRNA enrichment analysis revealed miR-130, 98, 124, 204 and 142 as the putative post-transcriptional regulators of the autophagy-lysosomal pathway genes. 155 miR-204 hsa-miR-204-5p,hsa-miR-204-3p MIMAT0000265,MIMAT0022693 miRNA autophagy Homo sapiens renal clear cell 23141280 9606 VHL-Regulated miR-204 suppresses tumor growth through inhibition of LC3B-mediated autophagy in renal clear cell carcinoma. 156 miR-204-5p hsa-miR-204-5p MIMAT0000265 miRNA MAP1LC3B autophagy down Homo sapiens colorectal cancer cell 25209181 9606 81631 ATG8F|LC3B|MAP1A/1BLC3|MAP1LC3B-a HGNC:13352|MIM:609604|Ensembl:ENSG00000140941|HPRD:14358|Vega:OTTHUMG00000137654 16 16q24.2 microtubule-associated protein 1 light chain 3 beta protein-coding microtubule-associated protein 1 light chain 3 beta This may be explained by the fact that miR-204-5p increases in colorectal cancer cases in order to inhibit increased activity of LC3B-II in autophagy and Bcl2 against apoptosis posttranscriptionally and to take role as tumor suppressor. 157 miR-205 hsa-miR-205-5p,hsa-miR-205-3p MIMAT0000266,MIMAT0009197 miRNA LAMP3 autophagy down Homo sapiens prostate cancer cell 24370341 9606 27074 CD208|DC LAMP|DC-LAMP|DCLAMP|LAMP|LAMP-3|TSC403 HGNC:14582|MIM:605883|Ensembl:ENSG00000078081|HPRD:12062|Vega:OTTHUMG00000158387 3 3q26.3-q27 lysosomal-associated membrane protein 3 protein-coding lysosomal-associated membrane protein 3 Specifically, the constraints on the autophagic flux were associated to the miRNA-dependent down-regulation of the lysosome-associated proteins RAB27A and LAMP3. These findings suggest that miR-205-mediated impairment of the autophagic pathway may interfere with the detoxifying capabilities of prostate cancer cells in their attempt to cope with cisplatin-induced detrimental effects. 158 miR-205 hsa-miR-205-5p,hsa-miR-205-3p MIMAT0000266,MIMAT0009197 miRNA RAB27A autophagy down Homo sapiens prostate cancer cell 24370341 9606 5873 GS2|HsT18676|RAB27|RAM HGNC:9766|MIM:603868|Ensembl:ENSG00000069974|HPRD:04845|Vega:OTTHUMG00000131959 15 15q15-q21.1 RAB27A, member RAS oncogene family protein-coding RAB27A, member RAS oncogene family Specifically, the constraints on the autophagic flux were associated to the miRNA-dependent down-regulation of the lysosome-associated proteins RAB27A and LAMP3. These findings suggest that miR-205-mediated impairment of the autophagic pathway may interfere with the detoxifying capabilities of prostate cancer cells in their attempt to cope with cisplatin-induced detrimental effects. 159 miR-20a hsa-miR-20a-5p,hsa-miR-20a-3p MIMAT0000075,MIMAT0004493 miRNA ATG7 autophagy down Homo sapiens hepatocellular carcinoma 25617127 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 The overexpressed PTENP1 decoyed oncomirs miR-17, miR-19b and miR-20a, which would otherwise target PTEN, PHLPP (a negative AKT regulator) and such autophagy genes as ULK1, ATG7 and p62, indicating that PTENP1 modulated the HCC cell behavior and gene networks by miRNA regulation. 160 miR-20a hsa-miR-20a-5p,hsa-miR-20a-3p MIMAT0000075,MIMAT0004493 miRNA SQSTM1 autophagy down Homo sapiens hepatocellular carcinoma 25617127 9606 8878 A170|OSIL|PDB3|ZIP3|p60|p62|p62B HGNC:11280|MIM:601530|Ensembl:ENSG00000161011|HPRD:03319|Vega:OTTHUMG00000150643 5 5q35 sequestosome 1 protein-coding sequestosome 1 The overexpressed PTENP1 decoyed oncomirs miR-17, miR-19b and miR-20a, which would otherwise target PTEN, PHLPP (a negative AKT regulator) and such autophagy genes as ULK1, ATG7 and p62, indicating that PTENP1 modulated the HCC cell behavior and gene networks by miRNA regulation. 161 miR-20a hsa-miR-20a-5p,hsa-miR-20a-3p MIMAT0000075,MIMAT0004493 miRNA ULK1 autophagy down Homo sapiens myoblast cell line cells 22781751 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 MiR-20a and miR-106b negatively regulate autophagy induced by leucine deprivation via suppression of ULK1 expression in C2C12 myoblasts. 162 miR-20a hsa-miR-20a-5p,hsa-miR-20a-3p MIMAT0000075,MIMAT0004493 miRNA ULK1 autophagy down Homo sapiens hepatocellular carcinoma 25617127 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 The overexpressed PTENP1 decoyed oncomirs miR-17, miR-19b and miR-20a, which would otherwise target PTEN, PHLPP (a negative AKT regulator) and such autophagy genes as ULK1, ATG7 and p62, indicating that PTENP1 modulated the HCC cell behavior and gene networks by miRNA regulation. 163 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA AKT1 autophagy down Homo sapiens malignant glioma cell line cells 23077620 9606 207 AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA HGNC:391|MIM:164730|Ensembl:ENSG00000142208|HPRD:01261|Vega:OTTHUMG00000170795 14 14q32.32 v-akt murine thymoma viral oncogene homolog 1 protein-coding v-akt murine thymoma viral oncogene homolog 1 Silencing of microRNA-21 confers radio-sensitivity through inhibition of the PI3K/AKT pathway and enhancing autophagy in malignant glioma cell lines. 164 miR-210 hsa-miR-210-5p,hsa-miR-210-3p MIMAT0000267,MIMAT0026475 miRNA BCL2 autophagy down Homo sapiens colon cancer 25385144 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 The inhibition of HIF-1¦Á decreased miR-210 expression and autophagy. Silencing of miR-210 upregulated Bcl-2 expression and reduced the survival fraction of colon cancer cells after radiation treatment. Under hypoxia, HIF-1¦Á induces miRNA-210 which in turn enhances autophagy and reduces radiosensitivity by downregulating Bcl-2 expression in colon cancer cells. 165 miR-210 hsa-miR-210-5p,hsa-miR-210-3p MIMAT0000267,MIMAT0026475 miRNA HIF1A autophagy up Homo sapiens colon cancer 25385144 9606 3091 HIF-1A|HIF-1alpha|HIF1|HIF1-ALPHA|MOP1|PASD8|bHLHe78 HGNC:4910|MIM:603348|Ensembl:ENSG00000100644|HPRD:04517|Vega:OTTHUMG00000140344 14 14q23.2 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) The inhibition of HIF-1¦Á decreased miR-210 expression and autophagy. Silencing of miR-210 upregulated Bcl-2 expression and reduced the survival fraction of colon cancer cells after radiation treatment. Under hypoxia, HIF-1¦Á induces miRNA-210 which in turn enhances autophagy and reduces radiosensitivity by downregulating Bcl-2 expression in colon cancer cells. 166 miR-214 hsa-miR-204-5p,hsa-miR-204-3p MIMAT0000265,MIMAT0022693 miRNA MAP1LC3A autophagy down Homo sapiens renal cell carcinoma 25517751 9606 84557 ATG8E|LC3|LC3A|MAP1ALC3|MAP1BLC3 HGNC:6838|MIM:601242|Ensembl:ENSG00000101460|HPRD:03144|Vega:OTTHUMG00000032306 20 20q11.22 microtubule-associated protein 1 light chain 3 alpha protein-coding microtubule-associated protein 1 light chain 3 alpha Increased expression of TRPM3 in RCC leads to Ca(2+) influx, activation of CAMKK2, AMPK, and ULK1, and phagophore formation. In addition, TRPM3 Ca(2+) and Zn(2+) fluxes inhibit miR-214, which directly targets LC3A and LC3B. 167 miR-214 hsa-miR-204-5p,hsa-miR-204-3p MIMAT0000265,MIMAT0022693 miRNA MAP1LC3B autophagy down Homo sapiens renal cell carcinoma 25517751 9606 81631 ATG8F|LC3B|MAP1A/1BLC3|MAP1LC3B-a HGNC:13352|MIM:609604|Ensembl:ENSG00000140941|HPRD:14358|Vega:OTTHUMG00000137654 16 16q24.2 microtubule-associated protein 1 light chain 3 beta protein-coding microtubule-associated protein 1 light chain 3 beta Increased expression of TRPM3 in RCC leads to Ca(2+) influx, activation of CAMKK2, AMPK, and ULK1, and phagophore formation. In addition, TRPM3 Ca(2+) and Zn(2+) fluxes inhibit miR-214, which directly targets LC3A and LC3B. 168 miR-214 hsa-miR-204-5p,hsa-miR-204-3p MIMAT0000265,MIMAT0022693 miRNA TRPM3 autophagy down Homo sapiens renal cell carcinoma 25517751 9606 80036 GON-2|LTRPC3|MLSN2 HGNC:17992|MIM:608961|Ensembl:ENSG00000083067|HPRD:10605|Vega:OTTHUMG00000019997 9 9q21.12 transient receptor potential cation channel, subfamily M, member 3 protein-coding transient receptor potential cation channel, subfamily M, member 3 Increased expression of TRPM3 in RCC leads to Ca(2+) influx, activation of CAMKK2, AMPK, and ULK1, and phagophore formation. In addition, TRPM3 Ca(2+) and Zn(2+) fluxes inhibit miR-214, which directly targets LC3A and LC3B. 169 miR-216a hsa-miR-216a-5p,hsa-miR-216a-3p MIMAT0000273,MIMAT0022844 miRNA ATG5 autophagy down Homo sapiens umbilical vein endothelial cell 24481443 9606 9474 APG5|APG5-LIKE|APG5L|ASP|hAPG5 HGNC:589|MIM:604261|Ensembl:ENSG00000057663|HPRD:16051|Vega:OTTHUMG00000016193 6 6q21 autophagy related 5 protein-coding autophagy related 5 We found that in young HUVECs, miR-216a overexpression repressed BECN1 and ATG5 expression and the ox-LDL induced autophagy, as evaluated by microtubule-associated protein 1 light chain 3 (LC3B) analysis and cytofluorimetric assay. 170 miR-216a hsa-miR-216a-5p,hsa-miR-216a-3p MIMAT0000273,MIMAT0022844 miRNA BECN1 autophagy down Homo sapiens umbilical vein endothelial cell 24481443 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related We found that in young HUVECs, miR-216a overexpression repressed BECN1 and ATG5 expression and the ox-LDL induced autophagy, as evaluated by microtubule-associated protein 1 light chain 3 (LC3B) analysis and cytofluorimetric assay. 171 miR-216a hsa-miR-216a-5p,hsa-miR-216a-3p MIMAT0000273,MIMAT0022844 miRNA LDLR autophagy down Homo sapiens umbilical vein endothelial cell 24481443 9606 3949 FH|FHC|LDLCQ2 HGNC:6547|MIM:606945|Ensembl:ENSG00000130164|HPRD:06091|Vega:OTTHUMG00000171935 19 19p13.2 low density lipoprotein receptor protein-coding low density lipoprotein receptor We found that in young HUVECs, miR-216a overexpression repressed BECN1 and ATG5 expression and the ox-LDL induced autophagy, as evaluated by microtubule-associated protein 1 light chain 3 (LC3B) analysis and cytofluorimetric assay. 172 miR-216b hsa-miR-216b-5p,hsa-miR-216b-5p MIMAT0004959,MIMAT0026721 miRNA BECN1 autophagy down Homo sapiens Tenon's fibroblasts 24681041 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related Further, we showed that miR-216b could directly target a specific fragment in the 3' untranslated region of Beclin 1 as demonstrated by luciferase assay, and consequently decreased the expression of Beclin 1. Consistently, knocking down Beclin 1 significantly decreased HCPT-triggered autophagy and apoptosis, and increased the viability of HTFs treated with HCPT, 173 miR-22 hsa-miR-22-5p,hsa-miR-22-3p MIMAT0004495,MIMAT0000077 miRNA HMGB1 autophagy down Homo sapiens osteosarcoma cells 24609901 9606 3146 HMG1|HMG3|SBP-1 HGNC:4983|MIM:163905|Ensembl:ENSG00000189403|HPRD:01228|Vega:OTTHUMG00000016670 13 13q12 high mobility group box 1 protein-coding high mobility group box 1 However, possibly as a compensatory effect, miR-22 was also upregulatedduring the chemotherapy, and the overexpressed miR-22 targeted the 3' UTR of HMGB1 and inhibits the HMGB1-promoted autophagy. 174 miR-22 hsa-miR-22-5p,hsa-miR-22-3p MIMAT0004495,MIMAT0000077 miRNA HMGB1 autophagy down Homo sapiens osteosarcoma cells 24752578 9606 3146 HMG1|HMG3|SBP-1 HGNC:4983|MIM:163905|Ensembl:ENSG00000189403|HPRD:01228|Vega:OTTHUMG00000016670 13 13q12 high mobility group box 1 protein-coding high mobility group box 1 Results demonstrated that miR-22 well paired with the 3'-UTR of HMGB1 downregulated the HMGB1 expression and blocked the HMGB1-mediated autophagy during chemotherapy in osteosarcoma cells in vitro. 175 miR-221 hsa-miR-221-3p,hsa-miR-221-5p MIMAT0000278,MIMAT0004568 miRNA CDK2 autophagy down Homo sapiens cardiomyocytes 25394488 9606 1017 CDKN2|p33(CDK2) HGNC:1771|MIM:116953|Ensembl:ENSG00000123374|HPRD:00310|Vega:OTTHUMG00000170575 12 12q13 cyclin-dependent kinase 2 protein-coding cyclin-dependent kinase 2 MicroRNA-221 inhibits autophagy and promotes heart failure by modulating the p27/CDK2/mTOR axis. 176 miR-221 hsa-miR-221-3p,hsa-miR-221-5p MIMAT0000278,MIMAT0004568 miRNA CDKN1B autophagy down Homo sapiens cardiomyocytes 25394488 9606 1027 CDKN4|KIP1|MEN1B|MEN4|P27KIP1 HGNC:1785|MIM:600778|Ensembl:ENSG00000111276|HPRD:02867|Vega:OTTHUMG00000149914 12 12p13.1-p12 cyclin-dependent kinase inhibitor 1B (p27, Kip1) protein-coding cyclin-dependent kinase inhibitor 1B (p27, Kip1) MicroRNA-221 inhibits autophagy and promotes heart failure by modulating the p27/CDK2/mTOR axis. 177 miR-221 hsa-miR-221-3p,hsa-miR-221-5p MIMAT0000278,MIMAT0004568 miRNA MTOR autophagy up Homo sapiens cardiomyocytes 25394488 9606 2475 FRAP|FRAP1|FRAP2|RAFT1|RAPT1 HGNC:3942|MIM:601231|Ensembl:ENSG00000198793|HPRD:03134|Vega:OTTHUMG00000002001 1 1p36.2 mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) MicroRNA-221 inhibits autophagy and promotes heart failure by modulating the p27/CDK2/mTOR axis. 178 miR-221 hsa-miR-221-3p,hsa-miR-221-5p MIMAT0000278,MIMAT0004568 miRNA autophagy Homo sapiens 22342941 9606 In this review, we focus on highlighting the dual functions of miRNAs as either oncogenes (e.g., miRNA-183, miRNA-376b, miRNA-106a, miRNA-221/222, miRNA-31 and miRNA-34c) or tumor suppressors (e.g., miRNA-30a, miRNA-101 and miRNA-9*) via mediating several autophagic signaling pathways in cancer pathogenesis. Taken together, these findings may uncover the regulatory mechanisms of oncogenic and tumor suppressive miRNAs in autophagy, which would provide a better understanding of miRNA-modulated autophagic signaling networks for future cancer therapeutics. 179 miR-221 hsa-miR-221-3p,hsa-miR-221-5p MIMAT0000278,MIMAT0004568 miRNA autophagy Homo sapiens breast cancer cell 23529451 9606 Here, we review the role of miR-221/222 in breast cancer (BCa) development and progression: regulating proliferative signaling pathways, altering telomere and telomerase activity, avoiding cell death from tumor suppressors, autophagy and apoptosis, monitoring angiogenesis, supporting epithelial-mesenchymal transition, and even controlling cell-specific function within microenvironment. 180 miR-222 hsa-miR-222-3p,hsa-miR-222-5p MIMAT0000279,MIMAT0004569 miRNA autophagy Homo sapiens 22342941 9606 In this review, we focus on highlighting the dual functions of miRNAs as either oncogenes (e.g., miRNA-183, miRNA-376b, miRNA-106a, miRNA-221/222, miRNA-31 and miRNA-34c) or tumor suppressors (e.g., miRNA-30a, miRNA-101 and miRNA-9*) via mediating several autophagic signaling pathways in cancer pathogenesis. Taken together, these findings may uncover the regulatory mechanisms of oncogenic and tumor suppressive miRNAs in autophagy, which would provide a better understanding of miRNA-modulated autophagic signaling networks for future cancer therapeutics. 181 miR-222 hsa-miR-222-3p,hsa-miR-222-5p MIMAT0000279,MIMAT0004569 miRNA autophagy Homo sapiens breast cancer cell 23529451 9606 Here, we review the role of miR-221/222 in breast cancer (BCa) development and progression: regulating proliferative signaling pathways, altering telomere and telomerase activity, avoiding cell death from tumor suppressors, autophagy and apoptosis, monitoring angiogenesis, supporting epithelial-mesenchymal transition, and even controlling cell-specific function within microenvironment. 182 miR-224 hsa-miR-224-5p,hsa-miR-224-3p MIMAT0009198,MIMAT0000281 miRNA SMAD4 autophagy down Homo sapiens hepatoma cell 23913306 9606 4089 DPC4|JIP|MADH4|MYHRS HGNC:6770|MIM:600993|Ensembl:ENSG00000141646|HPRD:02995|Vega:OTTHUMG00000132696 18 18q21.1 SMAD family member 4 protein-coding SMAD family member 4 our in vitro study demonstrated that miR-224 played an oncogenic role in hepatoma cell migration and tumor formation through silencing its target gene Smad4. 183 miR-224 hsa-miR-224-5p,hsa-miR-224-3p MIMAT0000281,MIMAT0009198 miRNA SMAD4 autophagy down Homo sapiens hepatocellular carcinoma cell 25068270 9606 4089 DPC4|JIP|MADH4|MYHRS HGNC:6770|MIM:600993|Ensembl:ENSG00000141646|HPRD:02995|Vega:OTTHUMG00000132696 18 18q21.1 SMAD family member 4 protein-coding SMAD family member 4 Based on this finding, we further demonstrated that in hepatitis B virus (HBV)-related HCC, aberrant autophagy (low autophagic activity) results in accumulation of MIR224 and decreased expression of the target gene Smad4, which leads to increased cell migration and tumor formation. 184 miR-23b hsa-miR-23b-3p,hsa-miR-23b-5p MIMAT0000418,MIMAT0004587 miRNA ATG12 autophagy down Homo sapiens pancreatic 23916944 9606 9140 APG12|APG12L|FBR93|HAPG12 HGNC:588|MIM:609608|Ensembl:ENSG00000145782|HPRD:08496|Vega:OTTHUMG00000128889 5 5q21-q22 autophagy related 12 protein-coding autophagy related 12 In pancreatic cancer cells, reduced levels of the miRNA miR-23b increase levels of ATG12 and autophagy to promote radioresistance. 185 miR-23b hsa-miR-23b-3p,hsa-miR-23b-5p MIMAT0000418,MIMAT0004587 miRNA ATG12 autophagy down Homo sapiens pancreatic cancer cell 24145177 9606 9140 APG12|APG12L|FBR93|HAPG12 HGNC:588|MIM:609608|Ensembl:ENSG00000145782|HPRD:08496|Vega:OTTHUMG00000128889 5 5q21-q22 autophagy related 12 protein-coding autophagy related 12 Here we demonstrated that MIR23B is a potent inhibitor of autophagy. MIR23B targets the 3-UTR of the autophagy-related gene ATG12, thereby decreasing autophagic activity and ultimately promoting radiation-induced pancreatic cancer cell death. 186 miR-24 hsa-miR-24-1-5p,hsa-miR-24-3p,hsa-miR-24-2-5p MIMAT0000079,MIMAT0000080,MIMAT0004497 miRNA autophagy Homo sapiens muscle cells 24063572 9606 In vitro, synthetic miR-24 overexpression had detrimental effects on SMC functional capacity inducing apoptosis, migration defects, enhanced autophagy, and loss of contractile marker genes. 187 miR-24-3p hsa-miR-24-3p MIMAT0000080 miRNA ATG4A autophagy down Homo sapiens SCLC cells 25426560 9606 115201 APG4A|AUTL2 HGNC:16489|MIM:300663|Ensembl:ENSG00000101844|HPRD:06455|Vega:OTTHUMG00000022176 X Xq22.1-q22.3 autophagy related 4A, cysteine peptidase protein-coding autophagy related 4A, cysteine peptidase We further found thatdownregulated miR-24-3p enhanced autophagy activation as it directly targets and inhibits autophagy-associated gene 4A (ATG4A). 188 miR-27 hsa-miR-27a-3p,hsa-miR-27a-5p,hsa-miR-27b-5p,hsa-miR-27b-3p MIMAT0000084,MIMAT0004501,MIMAT0004588,MIMAT0000419 miRNA autophagy Homo sapiens colon cancer 25526515 9606 We identified and selected four downregulated miRNAs including hsa-miR-302a-3p and 27 upregulated miRNAs under these two conditions as having the potential to target genes involved in the regulation of autophagy in human colon cancer cells. 189 miR-30 hsa-miR-30a-5p,hsa-miR-30a-3p,hsa-miR-30c-5p,hsa-miR-30d-5p,hsa-miR-30 MIMAT0000087,MIMAT0000088,MIMAT0000244,MIMAT000024 miRNA BECN1 autophagy down Homo sapiens cardiomyocyte cells 23326547 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related Angiotensin II induces down-regulation of miR-30 in cardiomyocytes, which in turn promotes myocardial hypertrophy through excessive autophagy. A dual luciferase reporter assay confirmed that beclin-1 was a target gene of miR-30a. 190 miR-302a-3p hsa-miR-302a-3p MIMAT0000684 miRNA autophagy Homo sapiens colon cancer 25526515 9606 We identified and selected four downregulated miRNAs including hsa-miR-302a-3p and 27 upregulated miRNAs under these two conditions as having the potential to target genes involved in the regulation of autophagy in human colon cancer cells. 191 miR-30a hsa-miR-30a-5p,hsa-miR-30a-3p MIMAT0000087,MIMAT0000088 miRNA ATG5 autophagy down Homo sapiens chronic myeloid leukemia cells 22395361 9606 9474 APG5|APG5-LIKE|APG5L|ASP|hAPG5 HGNC:589|MIM:604261|Ensembl:ENSG00000057663|HPRD:16051|Vega:OTTHUMG00000016193 6 6q21 autophagy related 5 protein-coding autophagy related 5 apoptosis specific protei miR-30a is a potent inhibitor of autophagy by downregulating Beclin 1 and ATG5 expression. 192 miR-30a hsa-miR-30a-5p,hsa-miR-30a-3p MIMAT0000087,MIMAT0000088 miRNA ATG5 autophagy down Homo sapiens chronic myelogenous leukemia cell 22617440 9606 9474 APG5|APG5-LIKE|APG5L|ASP|hAPG5 HGNC:589|MIM:604261|Ensembl:ENSG00000057663|HPRD:16051|Vega:OTTHUMG00000016193 6 6q21 autophagy related 5 protein-coding autophagy related 5 MIR30A, but not MIR101, is a potent inhibitor of autophagy by selectively downregulating BECN1 and ATG5 expression in CML cells. 193 miR-30a hsa-miR-30a-5p,hsa-miR-30a-3p MIMAT0000087,MIMAT0000088 miRNA ATG5 autophagy down Homo sapiens human chronic myeloid leukemia cells 22902544 9606 9474 APG5|APG5-LIKE|APG5L|ASP|hAPG5 HGNC:589|MIM:604261|Ensembl:ENSG00000057663|HPRD:16051|Vega:OTTHUMG00000016193 6 6q21 autophagy related 5 protein-coding autophagy related 5 ATG5-ATG12 forms a large multimeric complex with ATG16, which functions as the E3 ligase for LC3. Several miRNA regulators of this step have been identified including miR-30a, miR-181a and miR-374a (ATG5), miR-630 (ATG12), miR-376b (ATG4), miR-204 (LC3), miR-375 (ATG7), miR-519a (ATG10 and ATG16), miR-885-3p (ATG16) and miR-101 (ATG4 and RAB5A). 194 miR-30a hsa-miR-30a-5p,hsa-miR-30a-3p MIMAT0000087,MIMAT0000088 miRNA BECN1 autophagy down Homo sapiens breast cancer cells 19535919 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related ATG6 autophagy related 6 Beclin 1 is a potential target for miRNA miR-30a, and this miRNA could negatively regulate beclin 1 expression resulting in decreased autophagic activity. 195 miR-30a hsa-miR-30a-5p,hsa-miR-30a-3p MIMAT0000087,MIMAT0000088 miRNA BECN1 autophagy down Homo sapiens breast cancer cells 22157765 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related MicroRNA-30a sensitizes tumor cells to cis-platinum via suppressing beclin 1-mediated autophagy. 196 miR-30a hsa-miR-30a-5p,hsa-miR-30a-3p MIMAT0000087,MIMAT0000088 miRNA BECN1 autophagy down Homo sapiens chronic myelogenous leukemia cell 22617440 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related MIR30A, but not MIR101, is a potent inhibitor of autophagy by selectively downregulating BECN1 and ATG5 expression in CML cells. 197 miR-30a hsa-miR-30a-5p,hsa-miR-30a-3p MIMAT0000087,MIMAT0000088 miRNA BECN1 autophagy down Homo sapiens human chronic myeloid leukemia cells 22902544 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related ATG5-ATG12 forms a large multimeric complex with ATG16, which functions as the E3 ligase for LC3. Several miRNA regulators of this step have been identified including miR-30a, miR-181a and miR-374a (ATG5), miR-630 (ATG12), miR-376b (ATG4), miR-204 (LC3), miR-375 (ATG7), miR-519a (ATG10 and ATG16), miR-885-3p (ATG16) and miR-101 (ATG4 and RAB5A). 198 miR-30a hsa-miR-30a-5p,hsa-miR-30a-3p MIMAT0000087,MIMAT0000088 miRNA BECN1 autophagy down Homo sapiens H9c2 cell 23660952 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related Downregulated miR-30a activated autophagy by inhibiting beclin-1 expression in H9c2 cell. More important, autophagy inhibition suppressed miR-30a inhibitor-induced cardiomyocyte hypertrophy. 199 miR-30a hsa-miR-30a-5p,hsa-miR-30a-3p MIMAT0000087,MIMAT0000088 miRNA BECN1 autophagy Homo sapiens hepatic cell 25620738 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related To confirm these findings, HBx and miRNA-30a were coexpressed in HepG2 cells, and the results showed significant inhibition of autophagosome formation and beclin-1 and c-myc expression, 200 miR-30a hsa-miR-30a-5p,hsa-miR-30a-3p MIMAT0000087,MIMAT0000088 miRNA MYC autophagy down Homo sapiens hepatic cell 25620738 9606 4609 MRTL|MYCC|bHLHe39|c-Myc HGNC:7553|MIM:190080|Ensembl:ENSG00000136997|HPRD:01818|Vega:OTTHUMG00000128475 8 8q24.21 v-myc avian myelocytomatosis viral oncogene homolog protein-coding v-myc avian myelocytomatosis viral oncogene homolog To confirm these findings, HBx and miRNA-30a were coexpressed in HepG2 cells, and the results showed significant inhibition of autophagosome formation and beclin-1 and c-myc expression, 201 miR-30a hsa-miR-30a-5p,hsa-miR-30a-3p MIMAT0000087,MIMAT0000088 miRNA autophagy Homo sapiens 22342941 9606 In this review, we focus on highlighting the dual functions of miRNAs as either oncogenes (e.g., miRNA-183, miRNA-376b, miRNA-106a, miRNA-221/222, miRNA-31 and miRNA-34c) or tumor suppressors (e.g., miRNA-30a, miRNA-101 and miRNA-9*) via mediating several autophagic signaling pathways in cancer pathogenesis. Taken together, these findings may uncover the regulatory mechanisms of oncogenic and tumor suppressive miRNAs in autophagy, which would provide a better understanding of miRNA-modulated autophagic signaling networks for future cancer therapeutics. 202 miR-30b hsa-miR-30b-5p,hsa-miR-30b-3p MIMAT0000420,MIMAT0004589 miRNA ATG12 autophagy down Homo sapiens stomach 22647547 9606 9140 APG12|APG12L|FBR93|HAPG12 HGNC:588|MIM:609608|Ensembl:ENSG00000145782|HPRD:08496|Vega:OTTHUMG00000128889 5 5q21-q22 autophagy related 12 protein-coding autophagy related 12 As a potential mechanistic explanation for this observation, we demonstrate that MIR30B directly targets ATG12 and BECN1, which are important proteins involved in autophagy. 203 miR-30b hsa-miR-30b-5p,hsa-miR-30b-3p MIMAT0000420,MIMAT0004589 miRNA BECN1 autophagy down Homo sapiens stomach 22647547 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related As a potential mechanistic explanation for this observation, we demonstrate that MIR30B directly targets ATG12 and BECN2, which are important proteins involved in autophagy. 204 miR-30c hsa-miR-30c-5p,hsa-miR-30c-2-3p,hsa-miR-30c-1-3p MIMAT0000244,MIMAT0004550,MIMAT0004674 miRNA ATG16L1 autophagy down Homo sapiens ileal biopsy 24148619 9606 55054 APG16L|ATG16A|ATG16L|IBD10|WDR30 HGNC:21498|MIM:610767|Ensembl:ENSG00000085978|HPRD:16498|Vega:OTTHUMG00000133619 2 2q37.1 autophagy related 16-like 1 (S. cerevisiae) protein-coding autophagy related 16-like 1 (S. cerevisiae) In ileal biopsy samples of patients with CD, there was an inverse correlation between levels of MIR30C and MIR130A and those of ATG5 and ATG16L1, supporting in vitro findings. Inhibition of MIR30C and MIR130A in cultured intestinal epithelial cells and in mouse enterocytes blocked AIEC-induced inhibition of ATG5 and ATG16L1 expression and restored functional autophagy. 205 miR-30c hsa-miR-30c-5p,hsa-miR-30c-2-3p,hsa-miR-30c-1-3p MIMAT0000244,MIMAT0004550,MIMAT0004674 miRNA ATG5 autophagy down Homo sapiens ileal biopsy 24148619 9606 9474 APG5|APG5-LIKE|APG5L|ASP|hAPG5 HGNC:589|MIM:604261|Ensembl:ENSG00000057663|HPRD:16051|Vega:OTTHUMG00000016193 6 6q21 autophagy related 5 protein-coding autophagy related 5 In ileal biopsy samples of patients with CD, there was an inverse correlation between levels of MIR30C and MIR130A and those of ATG5 and ATG16L1, supporting in vitro findings. Inhibition of MIR30C and MIR130A in cultured intestinal epithelial cells and in mouse enterocytes blocked AIEC-induced inhibition of ATG5 and ATG16L1 expression and restored functional autophagy. 206 mir-30d hsa-miR-30d-5p,hsa-miR-30d-3p MIMAT0000245,MIMAT0004551 miRNA ATG12 autophagy down Homo sapiens epithelial 23274497 9606 9140 APG12|APG12L|FBR93|HAPG12 HGNC:588|MIM:609608|Ensembl:ENSG00000145782|HPRD:08496|Vega:OTTHUMG00000128889 5 5q21-q22 autophagy related 12 protein-coding autophagy related 12 Using a combined bioinformatics approach, gene set enrichment analysis, and miRNA target prediction, we found that mir-30d might regulate multiple genes in the autophagy pathway including BECN1, BNIP3L, ATG12, ATG5, and ATG2. 207 miR-30d hsa-miR-30d-5p,hsa-miR-30d-3p MIMAT0000245,MIMAT0004551 miRNA ATG2A autophagy down Homo sapiens epithelial cancer cells 23274497 9606 23130 - HGNC:29028|Ensembl:ENSG00000110046|HPRD:17186|Vega:OTTHUMG00000066831 11 11q13.1 autophagy related 2A protein-coding autophagy related 2A Using a combined bioinformatics approach, gene set enrichment analysis, and miRNA target prediction, we found that mir-30d might regulate multiple genes in the autophagy pathway including BECN1, BNIP3L, ATG12, ATG5, and ATG2. 208 mir-30d hsa-miR-30d-5p,hsa-miR-30d-3p MIMAT0000245,MIMAT0004551 miRNA ATG2B autophagy down Homo sapiens epithelial 23274497 9606 55102 C14orf103 HGNC:20187|Ensembl:ENSG00000066739|HPRD:12626|Vega:OTTHUMG00000149933 14 14q32.2 autophagy related 2B protein-coding autophagy related 2B Using a combined bioinformatics approach, gene set enrichment analysis, and miRNA target prediction, we found that mir-30d might regulate multiple genes in the autophagy pathway including BECN1, BNIP3L, ATG12, ATG5, and ATG2. 209 mir-30d hsa-miR-30d-5p,hsa-miR-30d-3p MIMAT0000245,MIMAT0004551 miRNA ATG5 autophagy down Homo sapiens epithelial 23274497 9606 9474 APG5|APG5-LIKE|APG5L|ASP|hAPG5 HGNC:589|MIM:604261|Ensembl:ENSG00000057663|HPRD:16051|Vega:OTTHUMG00000016193 6 6q21 autophagy related 5 protein-coding autophagy related 5 Using a combined bioinformatics approach, gene set enrichment analysis, and miRNA target prediction, we found that mir-30d might regulate multiple genes in the autophagy pathway including BECN1, BNIP3L, ATG12, ATG5, and ATG2. 210 mir-30d hsa-miR-30d-5p,hsa-miR-30d-3p MIMAT0000245,MIMAT0004551 miRNA BECN1 autophagy down Homo sapiens epithelial 23274497 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related Using a combined bioinformatics approach, gene set enrichment analysis, and miRNA target prediction, we found that mir-30d might regulate multiple genes in the autophagy pathway including BECN1, BNIP3L, ATG12, ATG5, and ATG2. 211 miR-30d hsa-miR-30d-5p,hsa-miR-30d-3p MIMAT0000245,MIMAT0004551 miRNA BECN1 autophagy down Homo sapiens anaplastic thyroid carcinoma 24345332 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related A reporter gene assay demonstrated that the binding sequences of miR-30d in the beclin 1-3' UTR was the region required for the inhibition of beclin 1 expression by this miRNA. 212 miR-30d hsa-miR-30d-5p,hsa-miR-30d-3p MIMAT0000245,MIMAT0004551 miRNA BNIP3L autophagy down Homo sapiens epithelial cancer cells 23274497 9606 665 BNIP3a|NIX HGNC:1085|MIM:605368|Ensembl:ENSG00000104765|HPRD:07288|Vega:OTTHUMG00000099433 8 8p21 BCL2/adenovirus E1B 19kDa interacting protein 3-like protein-coding BCL2/adenovirus E1B 19kDa interacting protein 3-like Using a combined bioinformatics approach, gene set enrichment analysis, and miRNA target prediction, we found that mir-30d might regulate multiple genes in the autophagy pathway including BECN1, BNIP3L, ATG12, ATG5, and ATG2. 213 miR-31 hsa-miR-31-5p,hsa-miR-31-3p MIMAT0000089,MIMAT0004504 miRNA GSK3B autophagy down Homo sapiens 24343269 9606 2932 - HGNC:4617|MIM:605004|Ensembl:ENSG00000082701|HPRD:05418|Vega:OTTHUMG00000133765 3 3q13.3 glycogen synthase kinase 3 beta protein-coding glycogen synthase kinase 3 beta Importantly, cellular levels of PP2A, a phosphatase, were regulated by Mir155 and Mir31 to fine-tune autophagy. Diminished expression of PP2A led to inhibition of GSK3B, thus facilitating the prolonged activation of WNT and SHH signaling pathways. Sustained WNT and SHH signaling effectuated the expression of anti-inflammatory lipoxygenases, which in tandem inhibited IFNG-induced JAK-STAT signaling and contributed to evasion of autophagy. 214 miR-31 hsa-miR-31-5p,hsa-miR-31-3p MIMAT0000089,MIMAT0004504 miRNA HIF1A autophagy up Homo sapiens 20861672 9606 3091 HIF-1A|HIF-1alpha|HIF1|HIF1-ALPHA|MOP1|PASD8|bHLHe78 HGNC:4910|MIM:603348|Ensembl:ENSG00000100644|HPRD:04517|Vega:OTTHUMG00000140344 14 14q23.2 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) MiR-34c and miR-31 are associated with oxidative stress or activation of the hypoxic response/HIF1a, which is sufficient to drive authophagy/mitophagy. 215 miR-31 hsa-miR-31-5p,hsa-miR-31-3p MIMAT0000089,MIMAT0004504 miRNA PPP2R4 autophagy down Homo sapiens 24343269 9606 5524 PP2A|PR53|PTPA HGNC:9308|MIM:600756|Ensembl:ENSG00000119383|HPRD:02858|Vega:OTTHUMG00000020774 9 9q34 protein phosphatase 2A activator, regulatory subunit 4 protein-coding protein phosphatase 2A activator, regulatory subunit 4 Importantly, cellular levels of PP2A, a phosphatase, were regulated by Mir155 and Mir31 to fine-tune autophagy. Diminished expression of PP2A led to inhibition of GSK3B, thus facilitating the prolonged activation of WNT and SHH signaling pathways. Sustained WNT and SHH signaling effectuated the expression of anti-inflammatory lipoxygenases, which in tandem inhibited IFNG-induced JAK-STAT signaling and contributed to evasion of autophagy. 216 miR-31 hsa-miR-31-5p,hsa-miR-31-3p MIMAT0000089,MIMAT0004504 miRNA autophagy Homo sapiens 22342941 9606 In this review, we focus on highlighting the dual functions of miRNAs as either oncogenes (e.g., miRNA-183, miRNA-376b, miRNA-106a, miRNA-221/222, miRNA-31 and miRNA-34c) or tumor suppressors (e.g., miRNA-30a, miRNA-101 and miRNA-9*) via mediating several autophagic signaling pathways in cancer pathogenesis. Taken together, these findings may uncover the regulatory mechanisms of oncogenic and tumor suppressive miRNAs in autophagy, which would provide a better understanding of miRNA-modulated autophagic signaling networks for future cancer therapeutics. 217 miR-320a hsa-miR-320a MIMAT0000510 miRNA SNCA autophagy up Homo sapiens neuron 25207598 9606 6622 NACP|PARK1|PARK4|PD1 HGNC:11138|MIM:163890|Ensembl:ENSG00000145335|HPRD:01227 4 4q21 synuclein, alpha (non A4 component of amyloid precursor) protein-coding synuclein, alpha (non A4 component of amyloid precursor) Targeted suppression of chaperone-mediated autophagy by miR-320a promotes ¦Á-synuclein aggregation. 218 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA ATG9A autophagy down Homo sapiens 22902544 9606 79065 APG9L1|MGD3208|mATG9 HGNC:22408|MIM:612204|Ensembl:ENSG00000198925|HPRD:07979|Vega:OTTHUMG00000154557 2 2q35 autophagy related 9A protein-coding autophagy related 9A miR-34a, which besides its well-established effects related to cell-cycle arrest and senescence (39¨C41) has recently been identified as an inhibitor of autophagic flux and a direct regulator of ATG9A in mammalian cells 219 miR-34c hsa-miR-31-5p,hsa-miR-31-3p MIMAT0000089,MIMAT0004504 miRNA HIF1A autophagy up Homo sapiens caveolin-1(-/-) null stromal cells 20861672 9606 3091 HIF-1A|HIF-1alpha|HIF1|HIF1-ALPHA|MOP1|PASD8|bHLHe78 HGNC:4910|MIM:603348|Ensembl:ENSG00000100644|HPRD:04517|Vega:OTTHUMG00000140344 14 14q23.2 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) MiR-34c and miR-31 are associated with oxidative stress or activation of the hypoxic response/HIF1a, which is sufficient to drive authophagy/mitophagy. 220 miR-34c hsa-miR-34c-5p,hsa-miR-34c-3p MIMAT0000686,MIMAT0004677 miRNA autophagy Homo sapiens 22342941 9606 In this review, we focus on highlighting the dual functions of miRNAs as either oncogenes (e.g., miRNA-183, miRNA-376b, miRNA-106a, miRNA-221/222, miRNA-31 and miRNA-34c) or tumor suppressors (e.g., miRNA-30a, miRNA-101 and miRNA-9*) via mediating several autophagic signaling pathways in cancer pathogenesis. Taken together, these findings may uncover the regulatory mechanisms of oncogenic and tumor suppressive miRNAs in autophagy, which would provide a better understanding of miRNA-modulated autophagic signaling networks for future cancer therapeutics. 221 miR-372 hsa-miR-372-3p,hsa-miR-372-5p MIMAT0000724,MIMAT0026484 miRNA SQSTM1 autophagy up Homo sapiens 24991827 9606 8878 A170|OSIL|PDB3|ZIP3|p60|p62|p62B HGNC:11280|MIM:601530|Ensembl:ENSG00000161011|HPRD:03319|Vega:OTTHUMG00000150643 5 5q35 sequestosome 1 protein-coding sequestosome 1 YY1 regulated SQSTM1 expression through the epigenetic modulation of the transcription of MIR372 (microRNA 372) which was found to target SQSTM1 directly. During nutrient starvation, YY1 was stimulated to promote SQSTM1 expression and subsequent autophagy activation by suppressing MIR372 expression. 222 miR-374a hsa-miR-374a-5p,hsa-miR-374a-3p MIMAT0004688,MIMAT0000727 miRNA ATG10 autophagy Homo sapiens squamous cell carcinoma cell 22356768 9606 83734 APG10|APG10L|pp12616 HGNC:20315|MIM:610800|Ensembl:ENSG00000152348|HPRD:16497|Vega:OTTHUMG00000119041 5 5q14.1 autophagy related 10 protein-coding autophagy related 10 £¨We further found that specific miRNAs (miR-181a, miR-519a, miR-374a and miR-630), which are critical downstream targets of the p-¦¤Np63¦Á, modulated the protein levels of ATG5, ATG6/BECN1, ATG10, ATG12, ATG16L1 and UVRAG, adding another level of expression control for autophagic pathways in SCC cells upon cisplatin exposure. £©We identified APTs to directly interact with CD95 to promote de-palmitoylation, thus impairing apoptosis mediated through CD95. Specific inhibition of APTs by siRNAs, treatment with miRs-138/-424 and pharmacological approaches restore CD95-mediated apoptosis in CLL cells and other cancer cells, pointing to an important regulatory role of APTs in CD95 apoptosis. 223 miR-374a hsa-miR-374a-5p,hsa-miR-374a-3p MIMAT0000727,MIMAT0004688 miRNA ATG12 autophagy Homo sapiens squamous cell carcinoma cell 22356768 9606 9140 APG12|APG12L|FBR93|HAPG12 HGNC:588|MIM:609608|Ensembl:ENSG00000145782|HPRD:08496|Vega:OTTHUMG00000128889 5 5q21-q22 autophagy related 12 protein-coding autophagy related 12 We further found that specific miRNAs (miR-181a, miR-519a, miR-374a and miR-630), which are critical downstream targets of the p-¦¤Np63¦Á, modulated the protein levels of ATG5, ATG6/BECN1, ATG10, ATG12, ATG16L1 and UVRAG, adding another level of expression control for autophagic pathways in SCC cells upon cisplatin exposure. 224 miR-374a hsa-miR-374a-5p,hsa-miR-374a-3p MIMAT0000727,MIMAT0004688 miRNA ATG16L1 autophagy Homo sapiens squamous cell carcinoma cell 22356768 9606 55054 APG16L|ATG16A|ATG16L|IBD10|WDR30 HGNC:21498|MIM:610767|Ensembl:ENSG00000085978|HPRD:16498|Vega:OTTHUMG00000133619 2 2q37.1 autophagy related 16-like 1 (S. cerevisiae) protein-coding autophagy related 16-like 1 (S. cerevisiae) We further found that specific miRNAs (miR-181a, miR-519a, miR-374a and miR-630), which are critical downstream targets of the p-¦¤Np63¦Á, modulated the protein levels of ATG5, ATG6/BECN1, ATG10, ATG12, ATG16L1 and UVRAG, adding another level of expression control for autophagic pathways in SCC cells upon cisplatin exposure. 225 miR-374a hsa-miR-374a-5p,hsa-miR-374a-3p MIMAT0004688,MIMAT0000727 miRNA ATG5 autophagy Homo sapiens squamous cell carcinoma cell 22356768 9606 9474 APG5|APG5-LIKE|APG5L|ASP|hAPG5 HGNC:589|MIM:604261|Ensembl:ENSG00000057663|HPRD:16051|Vega:OTTHUMG00000016193 6 6q21 autophagy related 5 protein-coding autophagy related 5 We further found that specific miRNAs (miR-181a, miR-519a, miR-374a and miR-630), which are critical downstream targets of the p-¦¤Np63¦Á, modulated the protein levels of ATG5, ATG6/BECN1, ATG10, ATG12, ATG16L1 and UVRAG, adding another level of expression control for autophagic pathways in SCC cells upon cisplatin exposure. 226 miR-374a hsa-miR-374a-5p,hsa-miR-374a-3p MIMAT0000727,MIMAT0004688 miRNA ATG5 autophagy down Homo sapiens 22902544 9606 9474 APG5|APG5-LIKE|APG5L|ASP|hAPG5 HGNC:589|MIM:604261|Ensembl:ENSG00000057663|HPRD:16051|Vega:OTTHUMG00000016193 6 6q21 autophagy related 5 protein-coding autophagy related 5 ATG5-ATG12 forms a large multimeric complex with ATG16, which functions as the E3 ligase for LC3. Several miRNA regulators of this step have been identified including miR-30a, miR-181a and miR-374a (ATG5), miR-630 (ATG12), miR-376b (ATG4), miR-204 (LC3), miR-375 (ATG7), miR-519a (ATG10 and ATG16), miR-885-3p (ATG16) and miR-101 (ATG4 and RAB5A). 227 miR-374a hsa-miR-374a-5p,hsa-miR-374a-3p MIMAT0000727,MIMAT0004688 miRNA BECN1 autophagy Homo sapiens squamous cell carcinoma cell 22356768 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related We further found that specific miRNAs (miR-181a, miR-519a, miR-374a and miR-630), which are critical downstream targets of the p-¦¤Np63¦Á, modulated the protein levels of ATG5, ATG6/BECN1, ATG10, ATG12, ATG16L1 and UVRAG, adding another level of expression control for autophagic pathways in SCC cells upon cisplatin exposure. 228 miR-374a hsa-miR-374a-5p,hsa-miR-374a-3p MIMAT0000727,MIMAT0004688 miRNA TP63 autophagy down Homo sapiens squamous cell carcinoma cell 22356768 9606 8626 AIS|B(p51A)|B(p51B)|EEC3|KET|LMS|NBP|OFC8|RHS|SHFM4|TP53CP|TP53L|TP73L|p40|p51|p53CP|p63|p73H|p73L HGNC:15979|MIM:603273|Ensembl:ENSG00000073282|HPRD:04469|Vega:OTTHUMG00000156313 3 3q28 tumor protein p63 protein-coding tumor protein p63 We further found that specific miRNAs (miR-181a, miR-519a, miR-374a and miR-630), which are critical downstream targets of the p-¦¤Np63¦Á, modulated the protein levels of ATG5, ATG6/BECN1, ATG10, ATG12, ATG16L1 and UVRAG, adding another level of expression control for autophagic pathways in SCC cells upon cisplatin exposure. 229 miR-374a hsa-miR-374a-5p,hsa-miR-374a-3p MIMAT0004688,MIMAT0000727 miRNA UVRAG autophagy Homo sapiens squamous cell carcinoma cell 22356768 9606 7405 DHTX|VPS38|p63 HGNC:12640|MIM:602493|HPRD:03929 11 11q13.5 UV radiation resistance associated protein-coding UV radiation resistance associated We further found that specific miRNAs (miR-181a, miR-519a, miR-374a and miR-630), which are critical downstream targets of the p-¦¤Np63¦Á, modulated the protein levels of ATG5, ATG6/BECN1, ATG10, ATG12, ATG16L1 and UVRAG, adding another level of expression control for autophagic pathways in SCC cells upon cisplatin exposure. 230 miR-375 hsa-miR-375 MIMAT0000728 miRNA ATG7 autophagy down Homo sapiens hepatocellular carcinoma (HCC) cells 22504094 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 miR-375 inhibits autophagy by reducing expression of ATG7 and impairs viability of HCC cells under hypoxic conditions in culture and in mice. 231 miR-375 hsa-miR-375 MIMAT0000728 miRNA ATG7 autophagy down Homo sapiens hepatocellular carcinoma (HCC) cells 22902544 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 Although examples of inverse correlations between autophagy-regulating miRNAs and their targets in human cancers are emerging, including miR-375 and ATG7 in human HCC(33) and miR-204 and LC3B in RCC(27), little is known regarding the dynamics of the miRNA-autophagy interplay during tumor progression. 232 miR-375 hsa-miR-375 MIMAT0000728 miRNA ATG7 autophagy down Homo sapiens liver cancer cells 22929050 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 We found that MIR375 inhibited autophagosome formation, as indicated by the decreased number of green fluorescent protein (GFP)-LC3 puncta. In addition, both LC3-I and LC3-II detection and bafilomycin A1 assays supported that MIR375 blocked the conversion of LC3-I to LC3-II, which is required for the elongation of the phagopore and in turn, the formation of the autophagosome. 233 miR-375 hsa-miR-375 MIMAT0000728 miRNA ATG7 autophagy down Homo sapiens liver cancer cell 22929051 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 The suppression of ATG7 by MIR375 elucidated how MIR375 is able to block the conversion of LC3-I to LC3-II and thus to inhibit autophagy. 234 miR-375 hsa-miR-375 MIMAT0000728 miRNA MAP1LC3A autophagy down Homo sapiens liver cancer cell 22929050 9606 84557 ATG8E|LC3|LC3A|MAP1ALC3|MAP1BLC3 HGNC:6838|MIM:601242|Ensembl:ENSG00000101460|HPRD:03144|Vega:OTTHUMG00000032306 20 20q11.22 microtubule-associated protein 1 light chain 3 alpha protein-coding microtubule-associated protein 1 light chain 3 alpha We found that MIR375 inhibited autophagosome formation, as indicated by the decreased number of green fluorescent protein (GFP)-LC3 puncta. In addition, both LC3-I and LC3-II detection and bafilomycin A1 assays supported that MIR375 blocked the conversion of LC3-I to LC3-II, which is required for the elongation of the phagopore and in turn, the formation of the autophagosome. 235 miR-375 hsa-miR-375 MIMAT0000728 miRNA MAP1LC3B autophagy down Homo sapiens liver cancer cell 22929050 9606 81631 ATG8F|LC3B|MAP1A/1BLC3|MAP1LC3B-a HGNC:13352|MIM:609604|Ensembl:ENSG00000140941|HPRD:14358|Vega:OTTHUMG00000137654 16 16q24.2 microtubule-associated protein 1 light chain 3 beta protein-coding microtubule-associated protein 1 light chain 3 beta We found that MIR375 inhibited autophagosome formation, as indicated by the decreased number of green fluorescent protein (GFP)-LC3 puncta. In addition, both LC3-I and LC3-II detection and bafilomycin A1 assays supported that MIR375 blocked the conversion of LC3-I to LC3-II, which is required for the elongation of the phagopore and in turn, the formation of the autophagosome. 236 miR-375 hsa-miR-375 MIMAT0000728 miRNA SP1 autophagy down Homo sapiens K562 cell 22606351 9606 6667 - HGNC:11205|MIM:189906|Ensembl:ENSG00000185591|HPRD:01796|Vega:OTTHUMG00000170047 12 12q13.1 Sp1 transcription factor protein-coding Sp1 transcription factor This study has demonstrated that in the absence of p53 and p16, the induction of senescence by DOX was associated with upregulation of miR-375 and autophagy initiation. The anti-proliferative function of miR-375 is possibly exerted, at least in part, by targeting 14-3-3zeta and SP1 genes. 237 miR-375 hsa-miR-375 MIMAT0000728 miRNA YWHAZ autophagy down Homo sapiens K562 cell 22606351 9606 7534 14-3-3-zeta|HEL-S-3|HEL4|KCIP-1|YWHAD HGNC:12855|MIM:601288|Ensembl:ENSG00000164924|HPRD:03183|Vega:OTTHUMG00000134291 8 8q23.1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta protein-coding tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta This study has demonstrated that in the absence of p53 and p16, the induction of senescence by DOX was associated with upregulation of miR-375 and autophagy initiation. The anti-proliferative function of miR-375 is possibly exerted, at least in part, by targeting 14-3-3zeta and SP1 genes. 238 miR-376a hsa-miR-376a-2-5p,hsa-miR-376a-5p,hsa-miR-376a-3p MIMAT0000729,MIMAT0003386,MIMAT0022928 miRNA ATG4C autophagy down Homo sapiens MCF-7 and Huh7 cell 24358205 9606 84938 APG4-C|APG4C|AUTL1|AUTL3 HGNC:16040|MIM:611339|Ensembl:ENSG00000125703|HPRD:07473|Vega:OTTHUMG00000009142 1 1p31.3 autophagy related 4C, cysteine peptidase protein-coding autophagy related 4C, cysteine peptidase MIR376A is a regulator of starvation-induced autophagy.MIR376A shared the same seed sequence and had overlapping targets with MIR376B, and similarly blocked the expression of key autophagy proteins ATG4C and BECN1 (Beclin 1) 239 miR-376a hsa-miR-376a-2-5p,hsa-miR-376a-5p,hsa-miR-376a-3p MIMAT0000729,MIMAT0003386,MIMAT0022928 miRNA BECN1 autophagy down Homo sapiens MCF-7 and Huh7 cell 24358205 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related MIR376A is a regulator of starvation-induced autophagy.MIR376A shared the same seed sequence and had overlapping targets with MIR376B, and similarly blocked the expression of key autophagy proteins ATG4C and BECN1 (Beclin 1) 240 miR-376b hsa-miR-376b MIMAT0002172 miRNA ATG4C autophagy down Homo sapiens MCF-7 and Huh-7 cell 22248718 9606 84938 APG4-C|APG4C|AUTL1|AUTL3 HGNC:16040|MIM:611339|Ensembl:ENSG00000125703|HPRD:07473|Vega:OTTHUMG00000009142 1 1p31.3 autophagy related 4C, cysteine peptidase protein-coding autophagy related 4C, cysteine peptidase We discovered autophagy proteins ATG4C and BECN1 (Beclin 1) as cellular targets of miR-376b. Indeed, upon miRNA overexpression, both mRNA and protein levels of ATG4C and BECN1 were decreased. 241 miR-376b hsa-miR-376b MIMAT0002172 miRNA ATG4C autophagy down Homo sapiens 22902544 9606 84938 APG4-C|APG4C|AUTL1|AUTL3 HGNC:16040|MIM:611339|Ensembl:ENSG00000125703|HPRD:07473|Vega:OTTHUMG00000009142 1 1p31.3 autophagy related 4C, cysteine peptidase protein-coding autophagy related 4C, cysteine peptidase ATG5-ATG12 forms a large multimeric complex with ATG16, which functions as the E3 ligase for LC3. Several miRNA regulators of this step have been identified including miR-30a, miR-181a and miR-374a (ATG5), miR-630 (ATG12), miR-376b (ATG4), miR-204 (LC3), miR-375 (ATG7), miR-519a (ATG10 and ATG16), miR-885-3p (ATG16) and miR-101 (ATG4 and RAB5A). 242 miR-376b hsa-miR-376b MIMAT0002172 miRNA ATG4C autophagy down Homo sapiens MCF-7 and Huh7 cell 24358205 9606 84938 APG4-C|APG4C|AUTL1|AUTL3 HGNC:16040|MIM:611339|Ensembl:ENSG00000125703|HPRD:07473|Vega:OTTHUMG00000009142 1 1p31.3 autophagy related 4C, cysteine peptidase protein-coding autophagy related 4C, cysteine peptidase MIR376A is a regulator of starvation-induced autophagy.MIR376A shared the same seed sequence and had overlapping targets with MIR376B, and similarly blocked the expression of key autophagy proteins ATG4C and BECN1 (Beclin 1) 243 miR-376b hsa-miR-376b MIMAT0002172 miRNA BECN1 autophagy down Homo sapiens MCF-7 and Huh-7 cell 22248718 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related We discovered autophagy proteins ATG4C and BECN1 (Beclin 1) as cellular targets of miR-376b. Indeed, upon miRNA overexpression, both mRNA and protein levels of ATG4C and BECN1 were decreased. 244 miR-376b hsa-miR-376b MIMAT0002172 miRNA BECN1 autophagy down Homo sapiens breast cancer cells 22248719 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1. 245 miR-376b hsa-miR-376b MIMAT0002172 miRNA BECN1 autophagy down Homo sapiens 22902544 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related Vesicle nucleation mainly involves the Beclin-1 complex, which is positively or negatively regulated by a number of associated proteins. Beclin-1 itself is regulated by miR-30a, miR-376b and miR-519a. 246 miR-376b hsa-miR-376b MIMAT0002172 miRNA BECN1 autophagy down Homo sapiens MCF-7 and Huh7 cell 24358205 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related MIR376A is a regulator of starvation-induced autophagy.MIR376A shared the same seed sequence and had overlapping targets with MIR376B, and similarly blocked the expression of key autophagy proteins ATG4C and BECN1 (Beclin 1) 247 miR-376b hsa-miR-376b MIMAT0002172 miRNA autophagy Homo sapiens 22342941 9606 In this review, we focus on highlighting the dual functions of miRNAs as either oncogenes (e.g., miRNA-183, miRNA-376b, miRNA-106a, miRNA-221/222, miRNA-31 and miRNA-34c) or tumor suppressors (e.g., miRNA-30a, miRNA-101 and miRNA-9*) via mediating several autophagic signaling pathways in cancer pathogenesis. Taken together, these findings may uncover the regulatory mechanisms of oncogenic and tumor suppressive miRNAs in autophagy, which would provide a better understanding of miRNA-modulated autophagic signaling networks for future cancer therapeutics. 248 miR-4459 hsa-miR-4459 MIMAT0018981 miRNA ATG13 autophagy down Homo sapiens Embryonic Stem cell 25437332 9606 9776 KIAA0652|PARATARG8 HGNC:29091|MIM:615088|Ensembl:ENSG00000175224|HPRD:13809|Vega:OTTHUMG00000166538 11 11p11.2 autophagy related 13 protein-coding autophagy related 13 MiR-4459 could decrease the expression of its targets, CDC20B and ATG13, and thus altered stemness via cell cycle and autophagy. 249 miR-4459 hsa-miR-4459 MIMAT0018981 miRNA CDC20B autophagy down Homo sapiens Embryonic Stem cell 25437332 9606 166979 - HGNC:24222|Ensembl:ENSG00000164287|HPRD:13428|Vega:OTTHUMG00000131185 5 5q11.2 cell division cycle 20B protein-coding cell division cycle 20B MiR-4459 could decrease the expression of its targets, CDC20B and ATG13, and thus altered stemness via cell cycle and autophagy. 250 miR-4459 hsa-miR-4459 MIMAT0018981 miRNA TGFB2-OT1 autophagy Homo sapiens human umbilical vein endothelial cells 24879147 9606 103611157 HGNC:50629|Ensembl:ENSG00000281453 1 1q41 TGFB2 overlapping transcript 1 ncRNA TGFB2 overlapping transcript 1 In previous studies, we found a chemical small molecule, 3-benzyl-5-((2-nitrophenoxy) methyl)-dihydrofuran-2(3H)-one (3BDO), that inhibited autophagy in human umbilical vein endothelial cells (HUVECs) and neuronal cells.Finally, we used gene microarray, RNA interference, RNA-ChIP assay, bioinformatics, luciferase reporter assay, and other assays and found that 3BDO greatly decreased the level of a long noncoding RNA (lncRNA) derived from the 3' untranslated region (3'UTR) of TGFB2, known as FLJ11812.Further experiments results showed that FLJ11812 could bind with MIR4459 targeting ATG13 (autophagy-related 13), and ATG13 protein level was decreased along with 3BDO-decreased FLJ11812 level. 251 miR-451 hsa-miR-451a,hsa-miR-451b MIMAT0001631,MIMAT0019840 miRNA TSC1 autophagy down Homo sapiens HeLa cells 25209900 9606 7248 LAM|TSC HGNC:12362|MIM:605284|Ensembl:ENSG00000165699|HPRD:05594|Vega:OTTHUMG00000020844 9 9q34 tuberous sclerosis 1 protein-coding tuberous sclerosis 1 MiR-451 is decreased in hypertrophic cardiomyopathy and regulates autophagy by targeting TSC1. 252 miR-502 hsa-miR-502-5p,hsa-miR-502-3p MIMAT0002873,MIMAT0004775 miRNA RAB1B autophagy down Homo sapiens colon cancer cells 22580605 9606 81876 - HGNC:18370|MIM:612565|Ensembl:ENSG00000174903|HPRD:11469|Vega:OTTHUMG00000166916 11 11q12 RAB1B, member RAS oncogene family protein-coding RAB1B, member RAS oncogene family In this study, we discover a novel mechanism of autophagy regulated by hsa-miR-502-5p (miR-502) by suppression of Rab1B, a critical mediator of autophagy. 253 miR-519a hsa-miR-519a-3p,hsa-miR-519a-5p MIMAT0002869,MIMAT0005452 miRNA ATG10 autophagy Homo sapiens squamous cell carcinoma cell 22356768 9606 83734 APG10|APG10L|pp12616 HGNC:20315|MIM:610800|Ensembl:ENSG00000152348|HPRD:16497|Vega:OTTHUMG00000119041 5 5q14.1 autophagy related 10 protein-coding autophagy related 10 £¨We further found that specific miRNAs (miR-181a, miR-519a, miR-374a and miR-630), which are critical downstream targets of the p-¦¤Np63¦Á, modulated the protein levels of ATG5, ATG6/BECN1, ATG10, ATG12, ATG16L1 and UVRAG, adding another level of expression control for autophagic pathways in SCC cells upon cisplatin exposure.£©We identified APTs to directly interact with CD95 to promote de-palmitoylation, thus impairing apoptosis mediated through CD95. Specific inhibition of APTs by siRNAs, treatment with miRs-138/-424 and pharmacological approaches restore CD95-mediated apoptosis in CLL cells and other cancer cells, pointing to an important regulatory role of APTs in CD95 apoptosis. 254 miR-519a hsa-miR-519a-3p,hsa-miR-519a-5p MIMAT0002869,MIMAT0005452 miRNA ATG10 autophagy down Homo sapiens 22902544 9606 83734 APG10|APG10L|pp12616 HGNC:20315|MIM:610800|Ensembl:ENSG00000152348|HPRD:16497|Vega:OTTHUMG00000119041 5 5q14.1 autophagy related 10 protein-coding autophagy related 10 ATG5-ATG12 forms a large multimeric complex with ATG16, which functions as the E3 ligase for LC3. Several miRNA regulators of this step have been identified including miR-30a, miR-181a and miR-374a (ATG5), miR-630 (ATG12), miR-376b (ATG4), miR-204 (LC3), miR-375 (ATG7), miR-519a (ATG10 and ATG16), miR-885-3p (ATG16) and miR-101 (ATG4 and RAB5A). 255 miR-519a hsa-miR-519a-3p,hsa-miR-519a-5p MIMAT0002869,MIMAT0005452 miRNA ATG12 autophagy Homo sapiens squamous cell carcinoma cell 22356768 9606 9140 APG12|APG12L|FBR93|HAPG12 HGNC:588|MIM:609608|Ensembl:ENSG00000145782|HPRD:08496|Vega:OTTHUMG00000128889 5 5q21-q22 autophagy related 12 protein-coding autophagy related 12 We further found that specific miRNAs (miR-181a, miR-519a, miR-374a and miR-630), which are critical downstream targets of the p-¦¤Np63¦Á, modulated the protein levels of ATG5, ATG6/BECN1, ATG10, ATG12, ATG16L1 and UVRAG, adding another level of expression control for autophagic pathways in SCC cells upon cisplatin exposure. 256 miR-519a hsa-miR-519a-3p,hsa-miR-519a-5p MIMAT0002869,MIMAT0005452 miRNA ATG16L1 autophagy Homo sapiens squamous cell carcinoma cell 22356768 9606 55054 APG16L|ATG16A|ATG16L|IBD10|WDR30 HGNC:21498|MIM:610767|Ensembl:ENSG00000085978|HPRD:16498|Vega:OTTHUMG00000133619 2 2q37.1 autophagy related 16-like 1 (S. cerevisiae) protein-coding autophagy related 16-like 1 (S. cerevisiae) We further found that specific miRNAs (miR-181a, miR-519a, miR-374a and miR-630), which are critical downstream targets of the p-¦¤Np63¦Á, modulated the protein levels of ATG5, ATG6/BECN1, ATG10, ATG12, ATG16L1 and UVRAG, adding another level of expression control for autophagic pathways in SCC cells upon cisplatin exposure. 257 miR-519a hsa-miR-519a-3p,hsa-miR-519a-5p MIMAT0002869,MIMAT0005452 miRNA ATG16L1 autophagy down Homo sapiens 22902544 9606 55054 APG16L|ATG16A|ATG16L|IBD10|WDR30 HGNC:21498|MIM:610767|Ensembl:ENSG00000085978|HPRD:16498|Vega:OTTHUMG00000133619 2 2q37.1 autophagy related 16-like 1 (S. cerevisiae) protein-coding autophagy related 16-like 1 (S. cerevisiae) ATG5-ATG12 forms a large multimeric complex with ATG16, which functions as the E3 ligase for LC3. Several miRNA regulators of this step have been identified including miR-30a, miR-181a and miR-374a (ATG5), miR-630 (ATG12), miR-376b (ATG4), miR-204 (LC3), miR-375 (ATG7), miR-519a (ATG10 and ATG16), miR-885-3p (ATG16) and miR-101 (ATG4 and RAB5A). 258 miR-519a hsa-miR-519a-3p,hsa-miR-519a-5p MIMAT0002869,MIMAT0005452 miRNA ATG5 autophagy Homo sapiens squamous cell carcinoma cell 22356768 9606 9474 APG5|APG5-LIKE|APG5L|ASP|hAPG5 HGNC:589|MIM:604261|Ensembl:ENSG00000057663|HPRD:16051|Vega:OTTHUMG00000016193 6 6q21 autophagy related 5 protein-coding autophagy related 5 We further found that specific miRNAs (miR-181a, miR-519a, miR-374a and miR-630), which are critical downstream targets of the p-¦¤Np63¦Á, modulated the protein levels of ATG5, ATG6/BECN1, ATG10, ATG12, ATG16L1 and UVRAG, adding another level of expression control for autophagic pathways in SCC cells upon cisplatin exposure. 259 miR-519a hsa-miR-519a-3p,hsa-miR-519a-5p MIMAT0002869,MIMAT0005452 miRNA BECN1 autophagy Homo sapiens squamous cell carcinoma cell 22356768 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related We further found that specific miRNAs (miR-181a, miR-519a, miR-374a and miR-630), which are critical downstream targets of the p-¦¤Np63¦Á, modulated the protein levels of ATG5, ATG6/BECN1, ATG10, ATG12, ATG16L1 and UVRAG, adding another level of expression control for autophagic pathways in SCC cells upon cisplatin exposure. 260 miR-519a hsa-miR-519a-3p,hsa-miR-519a-5p MIMAT0002869,MIMAT0005452 miRNA BECN1 autophagy down Homo sapiens 22902544 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related Finally, miR-519a, which similarly to miR-30a was downregulated by cisplatin treatment, was also found to regulate BECN1 in a 3¡äUTR reporter¨Cbased assay and inhibition of this miRNA could mimic the effect of cisplatin treatment on the BECN1 3¡äUTR 261 miR-519a hsa-miR-519a-3p,hsa-miR-519a-5p MIMAT0002869,MIMAT0005452 miRNA TP63 autophagy down Homo sapiens squamous cell carcinoma cell 22356768 9606 8626 AIS|B(p51A)|B(p51B)|EEC3|KET|LMS|NBP|OFC8|RHS|SHFM4|TP53CP|TP53L|TP73L|p40|p51|p53CP|p63|p73H|p73L HGNC:15979|MIM:603273|Ensembl:ENSG00000073282|HPRD:04469|Vega:OTTHUMG00000156313 3 3q28 tumor protein p63 protein-coding tumor protein p63 We further found that specific miRNAs (miR-181a, miR-519a, miR-374a and miR-630), which are critical downstream targets of the p-¦¤Np63¦Á, modulated the protein levels of ATG5, ATG6/BECN1, ATG10, ATG12, ATG16L1 and UVRAG, adding another level of expression control for autophagic pathways in SCC cells upon cisplatin exposure. 262 miR-519a hsa-miR-519a-3p,hsa-miR-519a-5p MIMAT0002869,MIMAT0005452 miRNA UVRAG autophagy Homo sapiens squamous cell carcinoma cell 22356768 9606 7405 DHTX|VPS38|p63 HGNC:12640|MIM:602493|HPRD:03929 11 11q13.5 UV radiation resistance associated protein-coding UV radiation resistance associated We further found that specific miRNAs (miR-181a, miR-519a, miR-374a and miR-630), which are critical downstream targets of the p-¦¤Np63¦Á, modulated the protein levels of ATG5, ATG6/BECN1, ATG10, ATG12, ATG16L1 and UVRAG, adding another level of expression control for autophagic pathways in SCC cells upon cisplatin exposure. 263 miR-630 hsa-miR-630 MIMAT0003299 miRNA ATG10 autophagy Homo sapiens squamous cell carcinoma cell 22356768 9606 83734 APG10|APG10L|pp12616 HGNC:20315|MIM:610800|Ensembl:ENSG00000152348|HPRD:16497|Vega:OTTHUMG00000119041 5 5q14.1 autophagy related 10 protein-coding autophagy related 10 We further found that specific miRNAs (miR-181a, miR-519a, miR-374a and miR-630), which are critical downstream targets of the p-¦¤Np63¦Á, modulated the protein levels of ATG5, ATG6/BECN1, ATG10, ATG12, ATG16L1 and UVRAG, adding another level of expression control for autophagic pathways in SCC cells upon cisplatin exposure. 264 miR-630 hsa-miR-630 MIMAT0003299 miRNA ATG12 autophagy Homo sapiens squamous cell carcinoma cell 22356768 9606 9140 APG12|APG12L|FBR93|HAPG12 HGNC:588|MIM:609608|Ensembl:ENSG00000145782|HPRD:08496|Vega:OTTHUMG00000128889 5 5q21-q22 autophagy related 12 protein-coding autophagy related 12 We further found that specific miRNAs (miR-181a, miR-519a, miR-374a and miR-630), which are critical downstream targets of the p-¦¤Np63¦Á, modulated the protein levels of ATG5, ATG6/BECN1, ATG10, ATG12, ATG16L1 and UVRAG, adding another level of expression control for autophagic pathways in SCC cells upon cisplatin exposure. 265 miR-630 hsa-miR-630 MIMAT0003299 miRNA ATG12 autophagy down Homo sapiens 22902544 9606 9140 APG12|APG12L|FBR93|HAPG12 HGNC:588|MIM:609608|Ensembl:ENSG00000145782|HPRD:08496|Vega:OTTHUMG00000128889 5 5q21-q22 autophagy related 12 protein-coding autophagy related 12 Other potential regulators of ATG5-ATG12 conjugation include miR-30a, miR-181a, miR-374a and miR-630 266 miR-630 hsa-miR-630 MIMAT0003299 miRNA ATG16L1 autophagy Homo sapiens squamous cell carcinoma cell 22356768 9606 55054 APG16L|ATG16A|ATG16L|IBD10|WDR30 HGNC:21498|MIM:610767|Ensembl:ENSG00000085978|HPRD:16498|Vega:OTTHUMG00000133619 2 2q37.1 autophagy related 16-like 1 (S. cerevisiae) protein-coding autophagy related 16-like 1 (S. cerevisiae) We further found that specific miRNAs (miR-181a, miR-519a, miR-374a and miR-630), which are critical downstream targets of the p-¦¤Np63¦Á, modulated the protein levels of ATG5, ATG6/BECN1, ATG10, ATG12, ATG16L1 and UVRAG, adding another level of expression control for autophagic pathways in SCC cells upon cisplatin exposure. 267 miR-630 hsa-miR-630 MIMAT0003299 miRNA ATG5 autophagy Homo sapiens squamous cell carcinoma cell 22356768 9606 9474 APG5|APG5-LIKE|APG5L|ASP|hAPG5 HGNC:589|MIM:604261|Ensembl:ENSG00000057663|HPRD:16051|Vega:OTTHUMG00000016193 6 6q21 autophagy related 5 protein-coding autophagy related 5 We further found that specific miRNAs (miR-181a, miR-519a, miR-374a and miR-630), which are critical downstream targets of the p-¦¤Np63¦Á, modulated the protein levels of ATG5, ATG6/BECN1, ATG10, ATG12, ATG16L1 and UVRAG, adding another level of expression control for autophagic pathways in SCC cells upon cisplatin exposure. 268 miR-630 hsa-miR-630 MIMAT0003299 miRNA BECN1 autophagy Homo sapiens squamous cell carcinoma cell 22356768 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related We further found that specific miRNAs (miR-181a, miR-519a, miR-374a and miR-630), which are critical downstream targets of the p-¦¤Np63¦Á, modulated the protein levels of ATG5, ATG6/BECN1, ATG10, ATG12, ATG16L1 and UVRAG, adding another level of expression control for autophagic pathways in SCC cells upon cisplatin exposure. 269 miR-630 hsa-miR-630 MIMAT0003299 miRNA TP63 autophagy down Homo sapiens squamous cell carcinoma cell 22356768 9606 8626 AIS|B(p51A)|B(p51B)|EEC3|KET|LMS|NBP|OFC8|RHS|SHFM4|TP53CP|TP53L|TP73L|p40|p51|p53CP|p63|p73H|p73L HGNC:15979|MIM:603273|Ensembl:ENSG00000073282|HPRD:04469|Vega:OTTHUMG00000156313 3 3q28 tumor protein p63 protein-coding tumor protein p63 We further found that specific miRNAs (miR-181a, miR-519a, miR-374a and miR-630), which are critical downstream targets of the p-¦¤Np63¦Á, modulated the protein levels of ATG5, ATG6/BECN1, ATG10, ATG12, ATG16L1 and UVRAG, adding another level of expression control for autophagic pathways in SCC cells upon cisplatin exposure. 270 miR-630 hsa-miR-630 MIMAT0003299 miRNA UVRAG autophagy Homo sapiens squamous cell carcinoma cell 22356768 9606 7405 DHTX|VPS38|p63 HGNC:12640|MIM:602493|HPRD:03929 11 11q13.5 UV radiation resistance associated protein-coding UV radiation resistance associated We further found that specific miRNAs (miR-181a, miR-519a, miR-374a and miR-630), which are critical downstream targets of the p-¦¤Np63¦Á, modulated the protein levels of ATG5, ATG6/BECN1, ATG10, ATG12, ATG16L1 and UVRAG, adding another level of expression control for autophagic pathways in SCC cells upon cisplatin exposure. 271 miR-885-3p hsa-miR-885-3p MIMAT0004948 miRNA AKT1 autophagy up Homo sapiens squamous carcinoma cells 22071691 9606 207 AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA HGNC:391|MIM:164730|Ensembl:ENSG00000142208|HPRD:01261|Vega:OTTHUMG00000170795 14 14q32.32 v-akt murine thymoma viral oncogene homolog 1 protein-coding v-akt murine thymoma viral oncogene homolog 1 PKB alpha|RAC-PK-alpha|RA The p-¦¤Np63¦Á-induced miR-885-3p functions as a critical regulator of MDM4, ATK1, BCL2, ATG16L2, ULK2, CASP2 and CASP3 mRNAs via pairing with their respective ¡°recognition¡± sequences. Altogether, our results support the notion that miR-885-3p might contribute in regulation of cell viability, apoptosis and/or autophagy in squamous cell carcinoma cells upon cisplatin exposure. 272 miR-885-3p hsa-miR-885-3p MIMAT0004948 miRNA ATG13 autophagy down Homo sapiens 22902544 9606 9776 KIAA0652|PARATARG8 HGNC:29091|MIM:615088|Ensembl:ENSG00000175224|HPRD:13809|Vega:OTTHUMG00000166538 11 11p11.2 autophagy related 13 protein-coding autophagy related 13 Interestingly, conserved, predicted binding sites for miR-885-3p exist in additional early autophagy-regulating genes, including the ULK-binding partner ATG13, as well as ATG9A and ATG2B, best known from yeast for their regulation of the retrieval step, where lipid and proteins are recruited to the phagophore assembly site (PAS) 273 miR-885-3p hsa-miR-885-3p MIMAT0004948 miRNA ATG16L2 autophagy up Homo sapiens squamous cell carcinoma cells 22071691 9606 89849 ATG16B|WDR80 HGNC:25464|Ensembl:ENSG00000168010|HPRD:10959|Vega:OTTHUMG00000167961 11 11q13.4 autophagy related 16-like 2 (S. cerevisiae) protein-coding autophagy related 16-like 2 (S. cerevisiae) The p-¦¤Np63¦Á-induced miR-885-3p functions as a critical regulator of MDM4, ATK1, BCL2, ATG16L2, ULK2, CASP2 and CASP3 mRNAs via pairing with their respective ¡°recognition¡± sequences. Altogether, our results support the notion that miR-885-3p might contribute in regulation of cell viability, apoptosis and/or autophagy in squamous cell carcinoma cells upon cisplatin exposure. 274 miR-885-3p hsa-miR-885-3p MIMAT0004948 miRNA ATG2B autophagy down Homo sapiens 22902544 9606 55102 C14orf103 HGNC:20187|Ensembl:ENSG00000066739|HPRD:12626|Vega:OTTHUMG00000149933 14 14q32.2 autophagy related 2B protein-coding autophagy related 2B Interestingly, conserved, predicted binding sites for miR-885-3p exist in additional early autophagy-regulating genes, including the ULK-binding partner ATG13, as well as ATG9A and ATG2B, best known from yeast for their regulation of the retrieval step, where lipid and proteins are recruited to the phagophore assembly site (PAS) 275 miR-885-3p hsa-miR-885-3p MIMAT0004948 miRNA ATG9A autophagy down Homo sapiens 22902544 9606 79065 APG9L1|MGD3208|mATG9 HGNC:22408|MIM:612204|Ensembl:ENSG00000198925|HPRD:07979|Vega:OTTHUMG00000154557 2 2q35 autophagy related 9A protein-coding autophagy related 9A Interestingly, conserved, predicted binding sites for miR-885-3p exist in additional early autophagy-regulating genes, including the ULK-binding partner ATG13, as well as ATG9A and ATG2B, best known from yeast for their regulation of the retrieval step, where lipid and proteins are recruited to the phagophore assembly site (PAS) 276 miR-885-3p hsa-miR-885-3p MIMAT0004948 miRNA MDM4 autophagy up Homo sapiens 22071691 9606 4194 HDMX|MDMX|MRP1 HGNC:6974|MIM:602704|Ensembl:ENSG00000198625|HPRD:04082|Vega:OTTHUMG00000035877 1 1q32 MDM4, p53 regulator protein-coding MDM4, p53 regulator The p-¦¤Np63¦Á-induced miR-885-3p functions as a critical regulator of MDM4, ATK1, BCL2, ATG16L2, ULK2, CASP2 and CASP3 mRNAs via pairing with their respective ¡°recognition¡± sequences. Altogether, our results support the notion that miR-885-3p might contribute in regulation of cell viability, apoptosis and/or autophagy in squamous cell carcinoma cells upon cisplatin exposure. 277 miR-885-3p hsa-miR-885-3p MIMAT0004948 miRNA ULK2 autophagy up Homo sapiens 22071691 9606 9706 ATG1B|Unc51.2 HGNC:13480|MIM:608650|Ensembl:ENSG00000083290|HPRD:10556|Vega:OTTHUMG00000059511 17 17p11.2 unc-51 like autophagy activating kinase 2 protein-coding unc-51 like autophagy activating kinase 2 The p-¦¤Np63¦Á-induced miR-885-3p functions as a critical regulator of MDM4, ATK1, BCL2, ATG16L2, ULK2, CASP2 and CASP3 mRNAs via pairing with their respective ¡°recognition¡± sequences. Altogether, our results support the notion that miR-885-3p might contribute in regulation of cell viability, apoptosis and/or autophagy in squamous cell carcinoma cells upon cisplatin exposure. 278 miR-9 hsa-miR-9-5p,hsa-miR-9-3p MIMAT0000441,MIMAT0000442 miRNA autophagy Homo sapiens 22342941 9606 In this review, we focus on highlighting the dual functions of miRNAs as either oncogenes (e.g., miRNA-183, miRNA-376b, miRNA-106a, miRNA-221/222, miRNA-31 and miRNA-34c) or tumor suppressors (e.g., miRNA-30a, miRNA-101 and miRNA-9*) via mediating several autophagic signaling pathways in cancer pathogenesis. Taken together, these findings may uncover the regulatory mechanisms of oncogenic and tumor suppressive miRNAs in autophagy, which would provide a better understanding of miRNA-modulated autophagic signaling networks for future cancer therapeutics. 279 miR-93 hsa-miR-93-5p,hsa-miR-93-3p MIMAT0000093,MIMAT0004509 miRNA ATG16L1 autophagy down Homo sapiens 24036151 9606 55054 APG16L|ATG16A|ATG16L|IBD10|WDR30 HGNC:21498|MIM:610767|Ensembl:ENSG00000085978|HPRD:16498|Vega:OTTHUMG00000133619 2 2q37.1 autophagy related 16-like 1 (S. cerevisiae) protein-coding autophagy related 16-like 1 (S. cerevisiae) Silencing Dicer1, an essential processor of miRs, increased levels of ATG protein and formation of autophagosomes in cells, indicating that miRs regulate autophagy. Luciferase reporter assays indicated that MIR106B and MIR93 targeted ATG16L1 messenger RNA. MIR106B and MIR93 reduced levels of ATG16L1 and autophagy; t 280 miR-93 hsa-miR-93-5p,hsa-miR-93-3p MIMAT0000093 ,MIMAT0004509 miRNA SQSTM1 autophagy up Homo sapiens myeloid 32D cells 22441107 9606 8878 A170|OSIL|PDB3|ZIP3|p60|p62|p62B HGNC:11280|MIM:601530|Ensembl:ENSG00000161011|HPRD:03319|Vega:OTTHUMG00000150643 5 5q35 sequestosome 1 protein-coding sequestosome 1 SQSTM1 (sequestosome 1/p62), a multiple domain protein that acts as a signaling hub, was identified as a key target for these miRNAs. SQSTM1 can interfere with autophagy via binding to the autophagic regulator Atg8/LC3. 281 miR-9-3p hsa-miR-9-3p MIMAT0000442 miRNA HDAC4 autophagy down Homo sapiens Waldenstrm macroglobulinemia (WM) cell 20519629 9606 9759 AHO3|BDMR|HA6116|HD4|HDAC-4|HDAC-A|HDACA HGNC:14063|MIM:605314|Ensembl:ENSG00000068024|HPRD:05610|Vega:OTTHUMG00000133344 2 2q37.3 histone deacetylase 4 protein-coding histone deacetylase 4 We found that restoring miRNA-9* levels induced toxicity in WM cells, supported by down-modulation of HDAC4 and HDAC5 and up-regulation of acetyl-histone-H3 and -H4. These, together with inhibited HDAC activity, led to induction of apoptosis and autophagy in WM cells. 282 miR-9-3p hsa-miR-9-3p MIMAT0000442 miRNA HDAC5 autophagy down Homo sapiens Waldenstrm macroglobulinemia (WM) cell 20519629 9606 10014 HD5|NY-CO-9 HGNC:14068|MIM:605315|Ensembl:ENSG00000108840|HPRD:09246|Vega:OTTHUMG00000181806 17 17q21 histone deacetylase 5 protein-coding histone deacetylase 5 We found that restoring miRNA-9* levels induced toxicity in WM cells, supported by down-modulation of HDAC4 and HDAC5 and up-regulation of acetyl-histone-H3 and -H4. These, together with inhibited HDAC activity, led to induction of apoptosis and autophagy in WM cells. 283 miR-9-3p hsa-miR-9-3p MIMAT0000442 miRNA HIST2H3C autophagy up Homo sapiens WM cell 20519629 9606 126961 H3|H3.2|H3/M|H3F2|H3FM|H3FN HGNC:20503|MIM:142780|HPRD:11822 1 1q21.2 histone cluster 2, H3c protein-coding histone cluster 2, H3c We found that restoring miRNA-9* levels induced toxicity in WM cells, supported by down-modulation of HDAC4 and HDAC5 and up-regulation of acetyl-histone-H3 and -H4. These, together with inhibited HDAC activity, led to induction of apoptosis and autophagy in WM cells. T 284 miR-9-3p hsa-miR-9-3p MIMAT0000442 miRNA HIST2H4A autophagy up Homo sapiens WM cell 20519629 9606 8370 FO108|H4|H4/n|H4F2|H4FN|HIST2H4 HGNC:4794|MIM:142750|Ensembl:ENSG00000183941|HPRD:11821|Vega:OTTHUMG00000012189 1 1q21.2 histone cluster 2, H4a protein-coding histone cluster 2, H4a We found that restoring miRNA-9* levels induced toxicity in WM cells, supported by down-modulation of HDAC4 and HDAC5 and up-regulation of acetyl-histone-H3 and -H4. These, together with inhibited HDAC activity, led to induction of apoptosis and autophagy in WM cells. T 285 miR-9-3p hsa-miR-9-3p MIMAT0000442 miRNA autophagy Homo sapiens 22342941 9606 In this review, we focus on highlighting the dual functions of miRNAs as either oncogenes (e.g., miRNA-183, miRNA-376b, miRNA-106a, miRNA-221/222, miRNA-31 and miRNA-34c) or tumor suppressors (e.g., miRNA-30a, miRNA-101 and miRNA-9*) via mediating several autophagic signaling pathways in cancer pathogenesis. Taken together, these findings may uncover the regulatory mechanisms of oncogenic and tumor suppressive miRNAs in autophagy, which would provide a better understanding of miRNA-modulated autophagic signaling networks for future cancer therapeutics. 286 miR-9-3p hsa-miR-9-3p MIMAT0000442 miRNA autophagy Homo sapiens SiHa cells 24944668 9606 miRNA-9* was also investigated. The results demonstrated that HCQ increased the expressions of LC3 mRNA and LC3II protein and GFP-LC3 signalling but reduced the expression of p62/STSQM1 in cervical cancer SiHa cells. These results indicated HCQ has the ability to inhibit autophagy as incapable of degrading the autophagosome. 287 miR-96 hsa-miR-96-5p,hsa-miR-96-3p MIMAT0000095,MIMAT0004510 miRNA ATG7 autophagy down Homo sapiens prostate cancer cells 25333253 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 Further studies have shown that high levels of miR-96 inhibited autophagy through suppressing ATG7, a key autophagy-associated gene. 288 miR-96 hsa-miR-96-5p,hsa-miR-96-3p MIMAT0000095,MIMAT0004510 miRNA MTOR autophagy down Homo sapiens prostate cancer cells 25333253 9606 2475 FRAP|FRAP1|FRAP2|RAFT1|RAPT1 HGNC:3942|MIM:601231|Ensembl:ENSG00000198793|HPRD:03134|Vega:OTTHUMG00000002001 1 1p36.2 mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) We report here hypoxia increased the expression of miR-96 in prostate cancer cells, and miR-96 stimulated autophagy by suppressing MTOR. 289 miR-96 hsa-miR-96-5p,hsa-miR-96-3p MIMAT0000095,MIMAT0004510 miRNA autophagy Homo sapiens 21293178 9606 MicroRNA enrichment analysis revealed miR-130, 98, 124, 204 and 142 as the putative post-transcriptional regulators of the autophagy-lysosomal pathway genes. 290 miR-98 hsa-miR-96-5p,hsa-miR-96-3p MIMAT0000095,MIMAT0004510 miRNA autophagy Homo sapiens 21293178 9606 MicroRNA enrichment analysis revealed miR-130, 98, 124, 204 and 142 as the putative post-transcriptional regulators of the autophagy-lysosomal pathway genes. 291 miR-UL148D(HCMV) hcmv-miR-UL148D MIMAT0001578 miRNA ERN1 autophagy Homo sapiens 24737391 9606 2081 IRE1|IRE1P|IRE1a|hIRE1p HGNC:3449|MIM:604033|Ensembl:ENSG00000178607|HPRD:04943|Vega:OTTHUMG00000178879 17 17q24.2 endoplasmic reticulum to nucleus signaling 1 protein-coding endoplasmic reticulum to nucleus signaling 1 The proapoptotic genes MOAP1, PHAP, and ERN1 are identified to be the potential targets for the miR-UL70-3p and UL148D, respectively. The ERN1 gene plays a role in the initiation of Endoplasmic reticulum stress-induced apoptosis as well as autophagosome formation. This study shows that HCMV employs its miRNA repertoire for countering the cellular apoptosis and autophagy, particularly the mitochondrial-dependent intrinsic pathway of apoptosis. 292 miR-UL70-3p(HCMV) hcmv-miR-UL70-3p MIMAT0003343 miRNA ERN1 autophagy Homo sapiens 24737391 9606 2081 IRE1|IRE1P|IRE1a|hIRE1p HGNC:3449|MIM:604033|Ensembl:ENSG00000178607|HPRD:04943|Vega:OTTHUMG00000178879 17 17q24.2 endoplasmic reticulum to nucleus signaling 1 protein-coding endoplasmic reticulum to nucleus signaling 1 The proapoptotic genes MOAP1, PHAP, and ERN1 are identified to be the potential targets for the miR-UL70-3p and UL148D, respectively. The ERN1 gene plays a role in the initiation of Endoplasmic reticulum stress-induced apoptosis as well as autophagosome formation. This study shows that HCMV employs its miRNA repertoire for countering the cellular apoptosis and autophagy, particularly the mitochondrial-dependent intrinsic pathway of apoptosis. 293 let-7b hsa-let-7b-5p,hsa-let-7b-3p MIMAT0000063,MIMAT0004482 miRNA ATG4B autophagy down Homo sapiens 22135297 9606 23192 APG4B|AUTL1 HGNC:20790|MIM:611338|Ensembl:ENSG00000168397|HPRD:16499|Vega:OTTHUMG00000151514 2 2q37.3 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 294 let-7i hsa-let-7i-5p,hsa-let-7i-3p MIMAT0000415,MIMAT0004585 miRNA IGF1R autophagy down Homo sapiens Jurkat cells 25305490 9606 3480 CD221|IGFIR|IGFR|JTK13 HGNC:5465|MIM:147370|Ensembl:ENSG00000140443|HPRD:00932|Vega:OTTHUMG00000149851 15 15q26.3 insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor Overexpression of let-7i inJurkat cells significantly suppressed IGF1R expression, which mimicked the actionof IGF1R siRNA. IGF1R inhibition led to a strinking decrease in phosphorylationof mTOR and Akt, down-regulation of Bcl-2, up-regulation of Bax and cleavage ofcaspase 3 and PARP. Meanwhile, IGF1R inhibition induced autophagy. 295 miR-100 hsa-miR-100-5p,hsa-miR-100-3p MIMAT0000098,MIMAT0004512 miRNA BECN1 autophagy down Homo sapiens 23622248 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 296 miR-101 hsa-miR-101-5p,hsa-miR-101-3p MIMAT0004513,MIMAT0000099 miRNA EZH2 autophagy up Homo sapiens HCC cell 24211739 9606 2146 ENX-1|ENX1|EZH1|EZH2b|KMT6|KMT6A|WVS|WVS2 HGNC:3527|MIM:601573|Ensembl:ENSG00000106462|HPRD:03342|Vega:OTTHUMG00000158973 7 7q35-q36 enhancer of zeste 2 polycomb repressive complex 2 subunit protein-coding enhancer of zeste 2 polycomb repressive complex 2 subunit MiR-101 expression was significantly downregulated in most of HCC tissues and all cell lines, whereas EZH2 was significantly overexpressed in most of HCC tissues and all cell lines. There was a negative correlation between expression levels of miR-101 and EZH2. Luciferase assay results confirmed EZH2 as a direct target gene of miR-101, which negatively regulates EZH2 expression in HCC. Ectopic overexpression of miR-101 dramatically repressed proliferation, invasion, colony formation as well as cell cycle progression in vitro and suppressed tumorigenicity in vivo. Furthermore, miR-101 inhibited autophagy and synergized with either doxorubicin or fluorouracil to induce apoptosis in tumor cells. 297 miR-101 hsa-miR-101-5p,hsa-miR-101-3p MIMAT0004513,MIMAT0000099 miRNA RAB5A autophagy Homo sapiens cardiomyocytes 25606826 9606 5868 RAB5 HGNC:9783|MIM:179512|Ensembl:ENSG00000144566|HPRD:01542|Vega:OTTHUMG00000129889 3 3p24-p22 RAB5A, member RAS oncogene family protein-coding RAB5A, member RAS oncogene family Further investigation identified Ras related protein Rab5A (RAB5A) as a direct target of miR-101. RAB5A was previously reported to be involved in autophagy; 298 miR-10a hsa-miR-10a-5p,hsa-miR-10a-3p MIMAT0000253,MIMAT0004555 miRNA ATG3 autophagy down Homo sapiens 23622248 9606 64422 APG3|APG3-LIKE|APG3L|PC3-96 HGNC:20962|MIM:609606|Ensembl:ENSG00000144848|HPRD:10654|Vega:OTTHUMG00000159260 3 3q13.2 autophagy related 3 protein-coding autophagy related 3 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 299 miR-1226 hsa-miR-1226-5p,hsa-miR-1226-3p MIMAT0005576,MIMAT0005577 miRNA PIK3R4 autophagy down Homo sapiens 23622248 9606 30849 VPS15|p150 HGNC:8982|MIM:602610|Ensembl:ENSG00000196455|HPRD:04010|Vega:OTTHUMG00000159645 3 3q22.1 phosphoinositide-3-kinase, regulatory subunit 4 protein-coding phosphoinositide-3-kinase, regulatory subunit 4 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 300 miR-124 hsa-miR-124-3p,hsa-miR-124-5p MIMAT0000422,MIMAT0004591 miRNA autophagy Homo sapiens colon cancer cell 25818238 9606 In this study, we investigated the role of miR-124 in colorectal adenoma (CRA) and cancer (CRC). The expression levels of miR-124 were decreased in CRA (81.8%) and CRC (57.6%) in 55 clinical samples. The ectopic expression of miR-124 induced apoptosis and autophagy in colon cancer cells. 301 miR-130b hsa-miR-130b-3p,hsa-miR-130b-5p MIMAT0000691,MIMAT0004680 miRNA FYCO1 autophagy down Homo sapiens 22135297 9606 79443 CATC2|CTRCT18|RUFY3|ZFYVE7 HGNC:14673|MIM:607182|Ensembl:ENSG00000163820|HPRD:06215|Vega:OTTHUMG00000133447 3 3p21.31 FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 302 miR-130b hsa-miR-130b-3p,hsa-miR-130b-5p MIMAT0000691,MIMAT0004680 miRNA UVRAG autophagy down Homo sapiens 22228303 9606 7405 DHTX|VPS38|p63 HGNC:12640|MIM:602493|HPRD:03929 11 11q13.5 UV radiation resistance associated protein-coding UV radiation resistance associated This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 303 miR-133b hsa-miR-130b-3p,hsa-miR-130b-5p MIMAT0000691,MIMAT0004680 miRNA RB1CC1 autophagy down Homo sapiens 23451058 9606 9821 ATG17|CC1|FIP200|PPP1R131 HGNC:15574|MIM:606837|Ensembl:ENSG00000023287|HPRD:06019|Vega:OTTHUMG00000164268 8 8q11 RB1-inducible coiled-coil 1 protein-coding RB1-inducible coiled-coil 1 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 304 miR-149 hsa-miR-149-5p,hsa-miR-149-3p MIMAT0000450,MIMAT0004609 miRNA PIK3C3 autophagy down Homo sapiens 23622248 9606 5289 VPS34|hVps34 HGNC:8974|MIM:602609|HPRD:04009 18 18q12.3 phosphatidylinositol 3-kinase, catalytic subunit type 3 protein-coding phosphatidylinositol 3-kinase, catalytic subunit type 3 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 305 miR-155 hsa-miR-155-5p,hsa-miR-155-3p MIMAT0000646,MIMAT0004658 miRNA ATG3 autophagy down Homo sapiens 22135297 9606 64422 APG3|APG3-LIKE|APG3L|PC3-96 HGNC:20962|MIM:609606|Ensembl:ENSG00000144848|HPRD:10654|Vega:OTTHUMG00000159260 3 3q13.2 autophagy related 3 protein-coding autophagy related 3 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 306 miR-155 hsa-miR-155-5p,hsa-miR-155-3p MIMAT0000646,MIMAT0004658 miRNA GABARAPL1 autophagy down Homo sapiens 20584899 9606 23710 APG8-LIKE|APG8L|ATG8|ATG8B|ATG8L|GEC1 HGNC:4068|MIM:607420|Ensembl:ENSG00000139112|HPRD:07601|Vega:OTTHUMG00000168411 12 12p13.2 GABA(A) receptor-associated protein like 1 protein-coding GABA(A) receptor-associated protein like 1 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 307 miR-155 hsa-miR-155-5p,hsa-miR-155-3p MIMAT0000646,MIMAT0004658 miRNA autophagy Homo sapiens osteosarcoma cell 25009614 9606 Our results demonstrated that microRNA-155 (miR-155) expression was highly induced during chemotherapy of osteosarcoma cells, and this was accompanied by upregulated autophagy. The increased miR-155 expression levels upregulated anticancer drug-induced autophagy in osteosarcoma cells and ameliorated the anticancer drug-induced cell proliferation and viability decrease. Therefore, the results of the present study demonstrated that miR-155 mediated drug-resistance in osteosarcoma cells by inducing autophagy. 308 miR-17 hsa-miR-17-5p,hsa-miR-17-3p MIMAT0000070,MIMAT0000071 miRNA BECN1 autophagy Homo sapiens lung cancer cells 25435430 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related MiR-17 overexpression reducedcytoprotective autophagy by targeting Beclin-1, whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2. 309 miR-17-5p hsa-miR-17-5p MIMAT0000070 miRNA BECN1 autophagy down Homo sapiens lung cancer cells A549 24755562 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related Overexpression of miR-17-5p into paclitaxel resistant lungcancer cells reduced beclin1 expression and a concordant decease in cellularautophagy. 310 miR-182 hsa-miR-182-5p,hsa-miR-182-3p MIMAT0000259,MIMAT0000260 miRNA ATG12 autophagy up Homo sapiens muscle cell 24871856 9606 9140 APG12|APG12L|FBR93|HAPG12 HGNC:588|MIM:609608|Ensembl:ENSG00000145782|HPRD:08496|Vega:OTTHUMG00000128889 5 5q21-q22 autophagy related 12 protein-coding autophagy related 12 Skeletal muscle atrophy occurs in response to a variety of conditions including chronic kidney disease, diabetes, cancer, and elevated glucocorticoids. MicroRNAs (miR) may play a role in the wasting process. Activation of the forkhead box O3 (FoxO3) transcription factor causes skeletal muscle atrophy in patients, animals, and cultured cells by increasing the expression of components of the ubiquitin-proteasome and autophagy-lysosome proteolytic systems. Transfection of miR-182 into muscle cells decreased FoxO3 mRNA 30% and FoxO3 protein 67% (P < 0.05) and also prevented a glucocorticoid-induced upregulation of multiple FoxO3 gene targets including MAFbx/atrogin-1, autophagy-related protein 12 (ATG12), cathepsin L, and microtubule-associated protein light chain 3 (LC3). 311 miR-182 hsa-miR-182-5p,hsa-miR-182-3p MIMAT0000259,MIMAT0000260 miRNA FOXO3 autophagy down Homo sapiens muscle cell 24871856 9606 2309 AF6q21|FKHRL1|FKHRL1P2|FOXO2|FOXO3A HGNC:3821|MIM:602681|Ensembl:ENSG00000118689|HPRD:04061|Vega:OTTHUMG00000015327 6 6q21 forkhead box O3 protein-coding forkhead box O3 Skeletal muscle atrophy occurs in response to a variety of conditions including chronic kidney disease, diabetes, cancer, and elevated glucocorticoids. MicroRNAs (miR) may play a role in the wasting process. Activation of the forkhead box O3 (FoxO3) transcription factor causes skeletal muscle atrophy in patients, animals, and cultured cells by increasing the expression of components of the ubiquitin-proteasome and autophagy-lysosome proteolytic systems. Transfection of miR-182 into muscle cells decreased FoxO3 mRNA 30% and FoxO3 protein 67% (P < 0.05) and also prevented a glucocorticoid-induced upregulation of multiple FoxO3 gene targets including MAFbx/atrogin-1, autophagy-related protein 12 (ATG12), cathepsin L, and microtubule-associated protein light chain 3 (LC3). 312 miR-183 hsa-miR-183-5p,hsa-miR-183-3p MIMAT0000261,MIMAT0004560 miRNA MAP1LC3B autophagy up Homo sapiens thyroid cell 21622722 9606 81631 ATG8F|LC3B|MAP1A/1BLC3|MAP1LC3B-a HGNC:13352|MIM:609604|Ensembl:ENSG00000140941|HPRD:14358|Vega:OTTHUMG00000137654 16 16q24.2 microtubule-associated protein 1 light chain 3 beta protein-coding microtubule-associated protein 1 light chain 3 beta Knock down of miR-183 expression in the TT cell line induced a significant decrease in the viable cell count and upregulation of the protein LC3B, which is associated with autophagy. 313 miR-186 hsa-miR-186-5p,hsa-miR-186-3p MIMAT0000456,MIMAT0004612 miRNA ULK1 autophagy down Homo sapiens 23622248 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 314 miR-188 hsa-miR-188-5p,hsa-miR-188-3p MIMAT0000457,MIMAT0004613 miRNA ATG16L1 autophagy down Homo sapiens 23622248 9606 55054 APG16L|ATG16A|ATG16L|IBD10|WDR30 HGNC:21498|MIM:610767|Ensembl:ENSG00000085978|HPRD:16498|Vega:OTTHUMG00000133619 2 2q37.1 autophagy related 16-like 1 (S. cerevisiae) protein-coding autophagy related 16-like 1 (S. cerevisiae) This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 315 miR-18a hsa-miR-18a-5p,hsa-miR-18a-3p MIMAT0000072,MIMAT0002891 miRNA HNRNPA1 autophagy down Homo sapiens colon cancer cell 24166503 9606 3178 ALS19|ALS20|HNRPA1|HNRPA1L3|IBMPFD3|hnRNP A1|hnRNP-A1 HGNC:5031|MIM:164017|Ensembl:ENSG00000135486|HPRD:01242|Vega:OTTHUMG00000169702 12 12q13.1 heterogeneous nuclear ribonucleoprotein A1 protein-coding heterogeneous nuclear ribonucleoprotein A1 An immunocytochemical study of hnRNP A1 and LC3-II and the inhibition of autophagy by 3-methyladenine and ATG7, p62 and BAG3 siRNA showed that miR-18a and hnRNP A1 formed a complex that was degraded through the autophagolysosomal pathway. This is the first report showing a novel function of a miR in the autophagolysosomal degradation of an oncogenic protein resulting from the creation of a complex consisting of the miR and a RNA-binding protein, which suppressed cancer progression. 316 miR-192 hsa-miR-192-5p,hsa-miR-192-3p MIMAT0000222,MIMAT0004543 miRNA ATG10 autophagy down Homo sapiens 22135297 9606 83734 APG10|APG10L|pp12616 HGNC:20315|MIM:610800|Ensembl:ENSG00000152348|HPRD:16497|Vega:OTTHUMG00000119041 5 5q14.1 autophagy related 10 protein-coding autophagy related 10 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 317 miR-192 hsa-miR-192-5p,hsa-miR-192-3p MIMAT0000222,MIMAT0004543 miRNA ATG4A autophagy down Homo sapiens 19074876 9606 115201 APG4A|AUTL2 HGNC:16489|MIM:300663|Ensembl:ENSG00000101844|HPRD:06455|Vega:OTTHUMG00000022176 X Xq22.1-q22.3 autophagy related 4A, cysteine peptidase protein-coding autophagy related 4A, cysteine peptidase This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 318 miR-192 hsa-miR-192-5p,hsa-miR-192-3p MIMAT0000222,MIMAT0004543 miRNA MAP1LC3B autophagy down Homo sapiens 22135297 9606 81631 ATG8F|LC3B|MAP1A/1BLC3|MAP1LC3B-a HGNC:13352|MIM:609604|Ensembl:ENSG00000140941|HPRD:14358|Vega:OTTHUMG00000137654 16 16q24.2 microtubule-associated protein 1 light chain 3 beta protein-coding microtubule-associated protein 1 light chain 3 beta This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 319 miR-192 hsa-miR-192-5p,hsa-miR-192-3p MIMAT0000222,MIMAT0004543 miRNA PIK3R4 autophagy down Homo sapiens 16822819 9606 30849 VPS15|p150 HGNC:8982|MIM:602610|Ensembl:ENSG00000196455|HPRD:04010|Vega:OTTHUMG00000159645 3 3q22.1 phosphoinositide-3-kinase, regulatory subunit 4 protein-coding phosphoinositide-3-kinase, regulatory subunit 4 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 320 miR-192 hsa-miR-192-5p,hsa-miR-192-3p MIMAT0000222,MIMAT0004543 miRNA UVRAG autophagy down Homo sapiens 22135297 9606 7405 DHTX|VPS38|p63 HGNC:12640|MIM:602493|HPRD:03929 11 11q13.5 UV radiation resistance associated protein-coding UV radiation resistance associated This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 321 miR-193b hsa-miR-193b-5p,hsa-miR-193b-3p MIMAT0004767,MIMAT0002819 miRNA RB1CC1 autophagy down Homo sapiens 23622248 9606 9821 ATG17|CC1|FIP200|PPP1R131 HGNC:15574|MIM:606837|Ensembl:ENSG00000023287|HPRD:06019|Vega:OTTHUMG00000164268 8 8q11 RB1-inducible coiled-coil 1 protein-coding RB1-inducible coiled-coil 1 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 322 miR-193b hsa-miR-193b-5p,hsa-miR-193b-3p MIMAT0004767,MIMAT0002819 miRNA RB1CC1 autophagy down Homo sapiens 23622248 9606 9821 ATG17|CC1|FIP200|PPP1R131 HGNC:15574|MIM:606837|Ensembl:ENSG00000023287|HPRD:06019|Vega:OTTHUMG00000164268 8 8q11 RB1-inducible coiled-coil 1 protein-coding RB1-inducible coiled-coil 1 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 323 miR-200c hsa-miR-200c-3p,hsa-miR-200c-5p MIMAT0000617,MIMAT0004657 miRNA HMOX1 autophagy down Homo sapiens clear cell renal cell 25150313 9606 3162 HMOX1D|HO-1|HSP32|bK286B10 HGNC:5013|MIM:141250|Ensembl:ENSG00000100292|HPRD:00782|Vega:OTTHUMG00000150960 22 22q13.1 heme oxygenase (decycling) 1 protein-coding heme oxygenase (decycling) 1 Combined application with chemotherapeutic drugs, miR-200c, a?HO-1 inhibitor, may enhance the efficiency of therapy by promoting both apoptosis and autophagy. 324 miR-204 hsa-miR-204-5p,hsa-miR-204-3p MIMAT0000265,MIMAT0022693 miRNA MAP1LC3B autophagy down Homo sapiens renal clear cell 22516261 9606 81631 ATG8F|LC3B|MAP1A/1BLC3|MAP1LC3B-a HGNC:13352|MIM:609604|Ensembl:ENSG00000140941|HPRD:14358|Vega:OTTHUMG00000137654 16 16q24.2 microtubule-associated protein 1 light chain 3 beta protein-coding microtubule-associated protein 1 light chain 3 beta VHL-regulated miR-204 suppresses tumor growth through inhibition of LC3B-mediated autophagy in renal clear cell carcinoma. 325 miR-20a hsa-miR-20a-5p,hsa-miR-20a-3p MIMAT0000075,MIMAT0004493 miRNA ATG12 autophagy down Homo sapiens osteoclast 25485521 9606 9140 APG12|APG12L|FBR93|HAPG12 HGNC:588|MIM:609608|Ensembl:ENSG00000145782|HPRD:08496|Vega:OTTHUMG00000128889 5 5q21-q22 autophagy related 12 protein-coding autophagy related 12 Results of chromatin immunoprecipitation assay showed that HIF-1¦Á binds to miRNA-20a. From miRNA Q-PCR results, we confirmed that shRNA HIF-1¦Á knockdown significantly downregulated both autophagy (LC3, p62, Atg5, Atg12, Atg16l1, Atg7, Becn1, Atg9a) and osteoclast markers (Traf6, Nfatc1, Ctsk, cFos, Mmp9, Trap) in RAW264.7 cells. 326 miR-20a hsa-miR-20a-5p,hsa-miR-20a-3p MIMAT0000075,MIMAT0004493 miRNA ATG16L1 autophagy down Homo sapiens osteoclast 25485521 9606 55054 APG16L|ATG16A|ATG16L|IBD10|WDR30 HGNC:21498|MIM:610767|Ensembl:ENSG00000085978|HPRD:16498|Vega:OTTHUMG00000133619 2 2q37.1 autophagy related 16-like 1 (S. cerevisiae) protein-coding autophagy related 16-like 1 (S. cerevisiae) The results from dual luciferase reporter assay revealed that miR-20a directly targets Atg16l1 by binding to its 3'UTR end. Further, miR-20a transfection studies showed significant down regulation of autophagic proteins (LC3-II and ATG16L1) and osteoclast differentiation markers (Nfatc1, Traf6, and Trap) thus confirming the functional role of miR-20a under hypoxic conditions. Results of chromatin immunoprecipitation assay showed that HIF-1¦Á binds to miRNA-20a. From miRNA Q-PCR results, we confirmed that shRNA HIF-1¦Á knockdown significantly downregulated both autophagy (LC3, p62, Atg5, Atg12, Atg16l1, Atg7, Becn1, Atg9a) and osteoclast markers (Traf6, Nfatc1, Ctsk, cFos, Mmp9, Trap) in RAW264.7 cells. Thus, our findings suggest that the regulatory axis of HIF-1¦Á-miRNA-20a-Atg16l1 might be a critical mechanism for hypoxia-induced osteoclast differentiation. 327 miR-20a hsa-miR-20a-5p,hsa-miR-20a-3p MIMAT0000075,MIMAT0004493 miRNA ATG5 autophagy down Homo sapiens osteoclast 25485521 9606 9474 APG5|APG5-LIKE|APG5L|ASP|hAPG5 HGNC:589|MIM:604261|Ensembl:ENSG00000057663|HPRD:16051|Vega:OTTHUMG00000016193 6 6q21 autophagy related 5 protein-coding autophagy related 5 Results of chromatin immunoprecipitation assay showed that HIF-1¦Á binds to miRNA-20a. From miRNA Q-PCR results, we confirmed that shRNA HIF-1¦Á knockdown significantly downregulated both autophagy (LC3, p62, Atg5, Atg12, Atg16l1, Atg7, Becn1, Atg9a) and osteoclast markers (Traf6, Nfatc1, Ctsk, cFos, Mmp9, Trap) in RAW264.7 cells. 328 miR-20a hsa-miR-20a-5p,hsa-miR-20a-3p MIMAT0000075,MIMAT0004493 miRNA ATG7 autophagy down Homo sapiens osteoclast 25485521 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 Results of chromatin immunoprecipitation assay showed that HIF-1¦Á binds to miRNA-20a. From miRNA Q-PCR results, we confirmed that shRNA HIF-1¦Á knockdown significantly downregulated both autophagy (LC3, p62, Atg5, Atg12, Atg16l1, Atg7, Becn1, Atg9a) and osteoclast markers (Traf6, Nfatc1, Ctsk, cFos, Mmp9, Trap) in RAW264.7 cells. 329 miR-20a hsa-miR-20a-5p,hsa-miR-20a-3p MIMAT0000075,MIMAT0004493 miRNA ATG9A autophagy down Homo sapiens osteoclast 25485521 9606 79065 APG9L1|MGD3208|mATG9 HGNC:22408|MIM:612204|Ensembl:ENSG00000198925|HPRD:07979|Vega:OTTHUMG00000154557 2 2q35 autophagy related 9A protein-coding autophagy related 9A Results of chromatin immunoprecipitation assay showed that HIF-1¦Á binds to miRNA-20a. From miRNA Q-PCR results, we confirmed that shRNA HIF-1¦Á knockdown significantly downregulated both autophagy (LC3, p62, Atg5, Atg12, Atg16l1, Atg7, Becn1, Atg9a) and osteoclast markers (Traf6, Nfatc1, Ctsk, cFos, Mmp9, Trap) in RAW264.7 cells. 330 miR-20a hsa-miR-20a-5p,hsa-miR-20a-3p MIMAT0000075,MIMAT0004493 miRNA BECN1 autophagy down Homo sapiens osteoclast 25485521 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related Results of chromatin immunoprecipitation assay showed that HIF-1¦Á binds to miRNA-20a. From miRNA Q-PCR results, we confirmed that shRNA HIF-1¦Á knockdown significantly downregulated both autophagy (LC3, p62, Atg5, Atg12, Atg16l1, Atg7, Becn1, Atg9a) and osteoclast markers (Traf6, Nfatc1, Ctsk, cFos, Mmp9, Trap) in RAW264.7 cells. 331 miR-20a hsa-miR-20a-5p,hsa-miR-20a-3p MIMAT0000075,MIMAT0004493 miRNA HIF1A autophagy down Homo sapiens osteoclast 25485521 9606 3091 HIF-1A|HIF-1alpha|HIF1|HIF1-ALPHA|MOP1|PASD8|bHLHe78 HGNC:4910|MIM:603348|Ensembl:ENSG00000100644|HPRD:04517|Vega:OTTHUMG00000140344 14 14q23.2 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) Results of chromatin immunoprecipitation assay showed that HIF-1¦Á binds to miRNA-20a. From miRNA Q-PCR results, we confirmed that shRNA HIF-1¦Á knockdown significantly downregulated both autophagy (LC3, p62, Atg5, Atg12, Atg16l1, Atg7, Becn1, Atg9a) and osteoclast markers (Traf6, Nfatc1, Ctsk, cFos, Mmp9, Trap) in RAW264.7 cells. 332 miR-20a hsa-miR-20a-5p,hsa-miR-20a-3p MIMAT0000075,MIMAT0004493 miRNA MAP1LC3B autophagy down Homo sapiens osteoclast 25485521 9606 81631 ATG8F|LC3B|MAP1A/1BLC3|MAP1LC3B-a HGNC:13352|MIM:609604|Ensembl:ENSG00000140941|HPRD:14358|Vega:OTTHUMG00000137654 16 16q24.2 microtubule-associated protein 1 light chain 3 beta protein-coding microtubule-associated protein 1 light chain 3 beta The results from dual luciferase reporter assay revealed that miR-20a directly targets Atg16l1 by binding to its 3'UTR end. Further, miR-20a transfection studies showed significant down regulation of autophagic proteins (LC3-II and ATG16L1) and osteoclast differentiation markers (Nfatc1, Traf6, and Trap) thus confirming the functional role of miR-20a under hypoxic conditions. Results of chromatin immunoprecipitation assay showed that HIF-1¦Á binds to miRNA-20a. From miRNA Q-PCR results, we confirmed that shRNA HIF-1¦Á knockdown significantly downregulated both autophagy (LC3, p62, Atg5, Atg12, Atg16l1, Atg7, Becn1, Atg9a) and osteoclast markers (Traf6, Nfatc1, Ctsk, cFos, Mmp9, Trap) in RAW264.7 cells. Thus, our findings suggest that the regulatory axis of HIF-1¦Á-miRNA-20a-Atg16l1 might be a critical mechanism for hypoxia-induced osteoclast differentiation. 333 miR-20a hsa-miR-20a-5p,hsa-miR-20a-3p MIMAT0000075,MIMAT0004493 miRNA SQSTM1 autophagy down Homo sapiens osteoclast 25485521 9606 8878 A170|OSIL|PDB3|ZIP3|p60|p62|p62B HGNC:11280|MIM:601530|Ensembl:ENSG00000161011|HPRD:03319|Vega:OTTHUMG00000150643 5 5q35 sequestosome 1 protein-coding sequestosome 1 Results of chromatin immunoprecipitation assay showed that HIF-1¦Á binds to miRNA-20a. From miRNA Q-PCR results, we confirmed that shRNA HIF-1¦Á knockdown significantly downregulated both autophagy (LC3, p62, Atg5, Atg12, Atg16l1, Atg7, Becn1, Atg9a) and osteoclast markers (Traf6, Nfatc1, Ctsk, cFos, Mmp9, Trap) in RAW264.7 cells. 334 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA BCL2 autophagy down Homo sapiens leukemia cells 23834154 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 MiR-21 downregulation also caused increased programmed cell death and a decrease in the expression levels of Bcl-2 protein, although PARP cleavage was not affected, indicating that apoptosis was not the relevant mechanism underlying the observed results. Treatment with antimiR-21 caused an increase in the autophagy related proteins Beclin-1, Vps34 and LC3-II. 335 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA BECN1 autophagy up Homo sapiens leukemia cells 23834154 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related MiR-21 downregulation also caused increased programmed cell death and a decrease in the expression levels of Bcl-2 protein, although PARP cleavage was not affected, indicating that apoptosis was not the relevant mechanism underlying the observed results. Treatment with antimiR-21 caused an increase in the autophagy related proteins Beclin-1, Vps34 and LC3-II. 336 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA MAP1LC3B autophagy up Homo sapiens leukemia cells 23834154 9606 81631 ATG8F|LC3B|MAP1A/1BLC3|MAP1LC3B-a HGNC:13352|MIM:609604|Ensembl:ENSG00000140941|HPRD:14358|Vega:OTTHUMG00000137654 16 16q24.2 microtubule-associated protein 1 light chain 3 beta protein-coding microtubule-associated protein 1 light chain 3 beta MiR-21 downregulation also caused increased programmed cell death and a decrease in the expression levels of Bcl-2 protein, although PARP cleavage was not affected, indicating that apoptosis was not the relevant mechanism underlying the observed results. Treatment with antimiR-21 caused an increase in the autophagy related proteins Beclin-1, Vps34 and LC3-II. 337 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA PIK3C3 autophagy up Homo sapiens leukemia cells 23834154 9606 5289 VPS34|hVps34 HGNC:8974|MIM:602609|HPRD:04009 18 18q12.3 phosphatidylinositol 3-kinase, catalytic subunit type 3 protein-coding phosphatidylinositol 3-kinase, catalytic subunit type 3 MiR-21 downregulation also caused increased programmed cell death and a decrease in the expression levels of Bcl-2 protein, although PARP cleavage was not affected, indicating that apoptosis was not the relevant mechanism underlying the observed results. Treatment with antimiR-21 caused an increase in the autophagy related proteins Beclin-1, Vps34 and LC3-II. 338 miR-215 hsa-miR-192-5p,hsa-miR-192-3p MIMAT0000222,MIMAT0004543 miRNA ATG10 autophagy down Homo sapiens 19074876 9606 83734 APG10|APG10L|pp12616 HGNC:20315|MIM:610800|Ensembl:ENSG00000152348|HPRD:16497|Vega:OTTHUMG00000119041 5 5q14.1 autophagy related 10 protein-coding autophagy related 10 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 339 miR-215 hsa-miR-192-5p,hsa-miR-192-3p MIMAT0000222,MIMAT0004543 miRNA ATG10 autophagy down Homo sapiens 19074876 9606 83734 APG10|APG10L|pp12616 HGNC:20315|MIM:610800|Ensembl:ENSG00000152348|HPRD:16497|Vega:OTTHUMG00000119041 5 5q14.1 autophagy related 10 protein-coding autophagy related 10 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 340 miR-215 hsa-miR-192-5p,hsa-miR-192-3p MIMAT0000222,MIMAT0004543 miRNA ATG4A autophagy down Homo sapiens 19074876 9606 115201 APG4A|AUTL2 HGNC:16489|MIM:300663|Ensembl:ENSG00000101844|HPRD:06455|Vega:OTTHUMG00000022176 X Xq22.1-q22.3 autophagy related 4A, cysteine peptidase protein-coding autophagy related 4A, cysteine peptidase This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 341 miR-215 hsa-miR-192-5p,hsa-miR-192-3p MIMAT0000222,MIMAT0004543 miRNA ATG4A autophagy down Homo sapiens 19074876 9606 115201 APG4A|AUTL2 HGNC:16489|MIM:300663|Ensembl:ENSG00000101844|HPRD:06455|Vega:OTTHUMG00000022176 X Xq22.1-q22.3 autophagy related 4A, cysteine peptidase protein-coding autophagy related 4A, cysteine peptidase This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 342 miR-215 hsa-miR-192-5p,hsa-miR-192-3p MIMAT0000222,MIMAT0004543 miRNA UVRAG autophagy down Homo sapiens 19074876 9606 7405 DHTX|VPS38|p63 HGNC:12640|MIM:602493|HPRD:03929 11 11q13.5 UV radiation resistance associated protein-coding UV radiation resistance associated This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 343 miR-215 hsa-miR-192-5p,hsa-miR-192-3p MIMAT0000222,MIMAT0004543 miRNA UVRAG autophagy down Homo sapiens 19074876 9606 7405 DHTX|VPS38|p63 HGNC:12640|MIM:602493|HPRD:03929 11 11q13.5 UV radiation resistance associated protein-coding UV radiation resistance associated This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 344 miR-22 hsa-miR-22-5p,hsa-miR-22-3p MIMAT0004495,MIMAT0000077 miRNA BTG1 autophagy Homo sapiens CRC cells 25449431 9606 694 - HGNC:1130|MIM:109580|HPRD:15912 12 12q22 B-cell translocation gene 1, anti-proliferative protein-coding B-cell translocation gene 1, anti-proliferative B-cell translocationgene 1 (BTG1) was identified as a new target of miR-22, which could reverse theinhibition of autophagy induced by miR-22. 345 miR-23b hsa-miR-23b-3p,hsa-miR-23b-5p MIMAT0000418,MIMAT0004587 miRNA ROS1 autophagy Homo sapiens 24755453 9606 6098 MCF3|ROS|c-ros-1 HGNC:10261|MIM:165020|Ensembl:ENSG00000047936|HPRD:01295|Vega:OTTHUMG00000016188 6 6q22 ROS proto-oncogene 1 , receptor tyrosine kinase protein-coding ROS proto-oncogene 1 , receptor tyrosine kinase Among the wide family of microRNAs, microRNA 23b (miR-23b) intriguingly assumes opposite roles on regulation of reactive oxygen species (ROS) and on the development of human cancers. Finally, we analyze the involvement of miR-23b in cancer cell metabolism, including autophagy, and in biomarker signatures of microRNAs allowing a prognostic and therapeutic evaluation in various human cancers. 346 miR-25 hsa-miR-25-3p,hsa-miR-25-5p MIMAT0004498,MIMAT0000081 miRNA ULK1 autophagy up Homo sapiens breast cancer cells 25026296 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 A mechanistic study validated that miR-25 inhibition led to autophagic cell death by directly increasing ULK1 expression,an early regulator in the autophagy induction phase. 347 miR-26b hsa-miR-26b-5p,hsa-miR-26b-3p MIMAT0004500,MIMAT0000083 miRNA GABARAP autophagy down Homo sapiens 22135297 9606 11337 ATG8A|GABARAP-a|MM46 HGNC:4067|MIM:605125|HPRD:05496 17 17p13.1 GABA(A) receptor-associated protein protein-coding GABA(A) receptor-associated protein This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 348 miR-26b hsa-miR-26b-5p,hsa-miR-26b-3p MIMAT0004500,MIMAT0000083 miRNA MAP1LC3C autophagy down Homo sapiens 19088304 9606 440738 ATG8J|LC3C HGNC:13353|MIM:609605|Ensembl:ENSG00000197769|HPRD:14226|Vega:OTTHUMG00000039865 1 1q43 microtubule-associated protein 1 light chain 3 gamma protein-coding microtubule-associated protein 1 light chain 3 gamma This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 349 miR-29b hsa-miR-29b-3p,hsa-miR-29b-1-5p,hsa-miR-29b-2-5p MIMAT0000100,MIMAT0004514,MIMAT0004515 miRNA PSME4 autophagy Homo sapiens 25234165 9606 23198 PA200 HGNC:20635|MIM:607705|Ensembl:ENSG00000068878|HPRD:09652|Vega:OTTHUMG00000151852 2 2p16.2 proteasome (prosome, macropain) activator subunit 4 protein-coding proteasome (prosome, macropain) activator subunit 4 Luciferase reporter assays demonstrated that miR-29b targeted PSME4 that encodes the proteasome activator PA200. Taken together, our study identifies miR-29b replacements as the first-in-class miR-based PIs that also disrupt the autophagy pathway and highlight their potential to synergistically enhance the antimyeloma effect of bortezomib. 350 miR-30a hsa-miR-30a-5p,hsa-miR-30a-3p MIMAT0000087,MIMAT0000088 miRNA BECN1 autophagy down Homo sapiens RCC cells 25712526 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related MiRNA-30a (miR-30a) is a potent inhibitor of autophagy by downregulating Beclin-1. 351 miR-30a hsa-miR-30a-5p,hsa-miR-30a-3p MIMAT0000087,MIMAT0000088 miRNA BECN1 autophagy up Homo sapiens neuroblastoma cells 24676932 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related To partly clarify this dualism, the effect of low-frequency EMF (LF-EMF) on the modulation of autophagy was investigated in human neuroblastoma SH-SY5Y cells, which were also subsequently exposed to A¦Â peptides, key players in AD. The results primarily point that LF-EMF induce a significant reduction of microRNA 30a (miR-30a) expression with a concomitant increase of Beclin1 transcript (BECN1) and its corresponding protein. Taking into account the pivotal role of autophagy in the clearance of protein aggregates within the cells, our results indicate a potential cytoprotective effect exerted by LF-EMF in neurodegenerative diseases such as AD. 352 miR-30a hsa-miR-30a-5p,hsa-miR-30a-3p MIMAT0000087,MIMAT0000088 miRNA GABARAPL2 autophagy down Homo sapiens 22135297 9606 11345 ATG8|ATG8C|GATE-16|GATE16|GEF-2|GEF2 HGNC:13291|MIM:607452|Ensembl:ENSG00000034713|HPRD:16246|Vega:OTTHUMG00000137613 16 16q22.1 GABA(A) receptor-associated protein-like 2 protein-coding GABA(A) receptor-associated protein-like 2 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 353 miR-30a hsa-miR-30a-5p,hsa-miR-30a-3p MIMAT0000087,MIMAT0000088 miRNA MAP1LC3B autophagy down Homo sapiens 22135297 9606 81631 ATG8F|LC3B|MAP1A/1BLC3|MAP1LC3B-a HGNC:13352|MIM:609604|Ensembl:ENSG00000140941|HPRD:14358|Vega:OTTHUMG00000137654 16 16q24.2 microtubule-associated protein 1 light chain 3 beta protein-coding microtubule-associated protein 1 light chain 3 beta This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 354 miR-30a hsa-miR-30a-5p,hsa-miR-30a-3p MIMAT0000087,MIMAT0000088 miRNA MAP1LC3B2 autophagy down Homo sapiens 18668040 9606 643246 ATG8G HGNC:34390|Ensembl:ENSG00000171471 12 12q24.22 microtubule-associated protein 1 light chain 3 beta 2 protein-coding microtubule-associated protein 1 light chain 3 beta 2 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 355 miR-32 hsa-miR-32-5p,hsa-miR-32-3p MIMAT0000090,MIMAT0004505 miRNA UVRAG autophagy down Homo sapiens 22135297 9606 7405 DHTX|VPS38|p63 HGNC:12640|MIM:602493|HPRD:03929 11 11q13.5 UV radiation resistance associated protein-coding UV radiation resistance associated This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 356 miR-320a hsa-miR-320a MIMAT0000510 miRNA ULK1 autophagy down Homo sapiens 23622248 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 357 miR-330 hsa-miR-330-3p,hsa-miR-330-5p MIMAT0000751,MIMAT0004693 miRNA PIK3R4 autophagy down Homo sapiens 23622248 9606 30849 VPS15|p150 HGNC:8982|MIM:602610|Ensembl:ENSG00000196455|HPRD:04010|Vega:OTTHUMG00000159645 3 3q22.1 phosphoinositide-3-kinase, regulatory subunit 4 protein-coding phosphoinositide-3-kinase, regulatory subunit 4 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 358 miR-335 hsa-miR-335-5p,hsa-miR-335-3p MIMAT0000765,MIMAT0004703 miRNA ATG16L2 autophagy down Homo sapiens 18185580 9606 89849 ATG16B|WDR80 HGNC:25464|Ensembl:ENSG00000168010|HPRD:10959|Vega:OTTHUMG00000167961 11 11q13.4 autophagy related 16-like 2 (S. cerevisiae) protein-coding autophagy related 16-like 2 (S. cerevisiae) This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 359 miR-335 hsa-miR-335-5p,hsa-miR-335-3p MIMAT0000765,MIMAT0004703 miRNA GABARAPL1 autophagy down Homo sapiens 18185580 9606 23710 APG8-LIKE|APG8L|ATG8|ATG8B|ATG8L|GEC1 HGNC:4068|MIM:607420|Ensembl:ENSG00000139112|HPRD:07601|Vega:OTTHUMG00000168411 12 12p13.2 GABA(A) receptor-associated protein like 1 protein-coding GABA(A) receptor-associated protein like 1 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 360 miR-335 hsa-miR-335-5p,hsa-miR-335-3p MIMAT0000765,MIMAT0004703 miRNA MAP1LC3A autophagy down Homo sapiens 18185580 9606 84557 ATG8E|LC3|LC3A|MAP1ALC3|MAP1BLC3 HGNC:6838|MIM:601242|Ensembl:ENSG00000101460|HPRD:03144|Vega:OTTHUMG00000032306 20 20q11.22 microtubule-associated protein 1 light chain 3 alpha protein-coding microtubule-associated protein 1 light chain 3 alpha This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 361 miR-335 hsa-miR-335-5p,hsa-miR-335-3p MIMAT0000765,MIMAT0004703 miRNA MAP1LC3B autophagy down Homo sapiens 22135297 9606 81631 ATG8F|LC3B|MAP1A/1BLC3|MAP1LC3B-a HGNC:13352|MIM:609604|Ensembl:ENSG00000140941|HPRD:14358|Vega:OTTHUMG00000137654 16 16q24.2 microtubule-associated protein 1 light chain 3 beta protein-coding microtubule-associated protein 1 light chain 3 beta This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 362 miR-335 hsa-miR-335-5p,hsa-miR-335-3p MIMAT0000765,MIMAT0004703 miRNA SQSTM1 autophagy down Homo sapiens 22135297 9606 8878 A170|OSIL|PDB3|ZIP3|p60|p62|p62B HGNC:11280|MIM:601530|Ensembl:ENSG00000161011|HPRD:03319|Vega:OTTHUMG00000150643 5 5q35 sequestosome 1 protein-coding sequestosome 1 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 363 miR-335 hsa-miR-335-5p,hsa-miR-335-3p MIMAT0000765,MIMAT0004703 miRNA TECPR1 autophagy down Homo sapiens 22135297 9606 25851 - HGNC:22214|MIM:614781|Ensembl:ENSG00000205356|HPRD:08521|Vega:OTTHUMG00000154273 7 7q21.3 tectonin beta-propeller repeat containing 1 protein-coding tectonin beta-propeller repeat containing 1 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 364 miR-335 hsa-miR-335-5p,hsa-miR-335-3p MIMAT0000765,MIMAT0004703 miRNA ULK1 autophagy down Homo sapiens 22135297 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 365 miR-335 hsa-miR-335-5p,hsa-miR-335-3p MIMAT0000765,MIMAT0004703 miRNA ULK2 autophagy down Homo sapiens 18185580 9606 9706 ATG1B|Unc51.2 HGNC:13480|MIM:608650|Ensembl:ENSG00000083290|HPRD:10556|Vega:OTTHUMG00000059511 17 17p11.2 unc-51 like autophagy activating kinase 2 protein-coding unc-51 like autophagy activating kinase 2 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 366 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA ATG4B autophagy down Homo sapiens chronic myeloid leukemia 24755409 9606 23192 APG4B|AUTL1 HGNC:20790|MIM:611338|Ensembl:ENSG00000168397|HPRD:16499|Vega:OTTHUMG00000151514 2 2q37.3 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase Moreover, deregulated expression of ATG4B in CD34(+) CML cells inversely correlates with transcript levels of miR-34a, and ATG4B is shown to be a direct target of miR-34a. This study identifies ATG4B as a potential biomarker for predicting therapeutic response in treatment-na?ve CML stem/progenitor cells and uncovers ATG4B as a possible drug target in these cells. 367 miR-373 hsa-miR-373-5p,hsa-miR-373-3p MIMAT0000725,MIMAT0000726 miRNA FYCO1 autophagy down Homo sapiens 22135297 9606 79443 CATC2|CTRCT18|RUFY3|ZFYVE7 HGNC:14673|MIM:607182|Ensembl:ENSG00000163820|HPRD:06215|Vega:OTTHUMG00000133447 3 3p21.31 FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 368 miR-374b hsa-miR-374b-5p,hsa-miR-374b-3p MIMAT0004955,MIMAT0004956 miRNA GABARAPL1 autophagy down Homo sapiens 20371350 9606 23710 APG8-LIKE|APG8L|ATG8|ATG8B|ATG8L|GEC1 HGNC:4068|MIM:607420|Ensembl:ENSG00000139112|HPRD:07601|Vega:OTTHUMG00000168411 12 12p13.2 GABA(A) receptor-associated protein like 1 protein-coding GABA(A) receptor-associated protein like 1 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 369 miR-374b hsa-miR-374b-5p,hsa-miR-374b-3p MIMAT0004955,MIMAT0004956 miRNA GABARAPL1 autophagy down Homo sapiens 20371350 9606 23710 APG8-LIKE|APG8L|ATG8|ATG8B|ATG8L|GEC1 HGNC:4068|MIM:607420|Ensembl:ENSG00000139112|HPRD:07601|Vega:OTTHUMG00000168411 12 12p13.2 GABA(A) receptor-associated protein like 1 protein-coding GABA(A) receptor-associated protein like 1 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 370 miR-375 hsa-miR-375 MIMAT0000728 miRNA ATG7 autophagy down Homo sapiens 22135297 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 371 miR-375 hsa-miR-375 MIMAT0000728 miRNA RB1CC1 autophagy down Homo sapiens 22135297 9606 9821 ATG17|CC1|FIP200|PPP1R131 HGNC:15574|MIM:606837|Ensembl:ENSG00000023287|HPRD:06019|Vega:OTTHUMG00000164268 8 8q11 RB1-inducible coiled-coil 1 protein-coding RB1-inducible coiled-coil 1 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 372 miR-378a hsa-miR-378a-5p,hsa-miR-378a-3p MIMAT0000731,MIMAT0000732 miRNA FYCO1 autophagy down Homo sapiens 23622248 9606 79443 CATC2|CTRCT18|RUFY3|ZFYVE7 HGNC:14673|MIM:607182|Ensembl:ENSG00000163820|HPRD:06215|Vega:OTTHUMG00000133447 3 3p21.31 FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 373 miR-421 hsa-miR-421 MIMAT0003339 miRNA ATG2B autophagy down Homo sapiens 20371350 9606 55102 C14orf103 HGNC:20187|Ensembl:ENSG00000066739|HPRD:12626|Vega:OTTHUMG00000149933 14 14q32.2 autophagy related 2B protein-coding autophagy related 2B This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 374 miR-423 hsa-miR-423-5p,hsa-miR-423-3p MIMAT0004748,MIMAT0001340 miRNA SQSTM1 autophagy down Homo sapiens 23622248 9606 8878 A170|OSIL|PDB3|ZIP3|p60|p62|p62B HGNC:11280|MIM:601530|Ensembl:ENSG00000161011|HPRD:03319|Vega:OTTHUMG00000150643 5 5q35 sequestosome 1 protein-coding sequestosome 1 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 375 miR-423 hsa-miR-423-5p,hsa-miR-423-3p MIMAT0004748,MIMAT0001340 miRNA ULK1 autophagy down Homo sapiens 23622248 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 376 miR-423-5p hsa-miR-423-5p MIMAT0004748 miRNA autophagy Homo sapiens hepatocellular carcinoma cell 25782064 9606 MiR-423-5p was validated as positive regulator of autophagy in HCC cell lines by transient transfection of miR and anti-miR molecules. 377 miR-484 hsa-miR-484 MIMAT0002174 miRNA FYCO1 autophagy down Homo sapiens 23622248 9606 79443 CATC2|CTRCT18|RUFY3|ZFYVE7 HGNC:14673|MIM:607182|Ensembl:ENSG00000163820|HPRD:06215|Vega:OTTHUMG00000133447 3 3p21.31 FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 378 miR-484 hsa-miR-484 MIMAT0002174 miRNA SQSTM1 autophagy down Homo sapiens 23622248 9606 8878 A170|OSIL|PDB3|ZIP3|p60|p62|p62B HGNC:11280|MIM:601530|Ensembl:ENSG00000161011|HPRD:03319|Vega:OTTHUMG00000150643 5 5q35 sequestosome 1 protein-coding sequestosome 1 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 379 miR-503 hsa-miR-503-5p,hsa-miR-503-3p MIMAT0022925,MIMAT0002874 miRNA PIK3R4 autophagy down Homo sapiens 23622248 9606 30849 VPS15|p150 HGNC:8982|MIM:602610|Ensembl:ENSG00000196455|HPRD:04010|Vega:OTTHUMG00000159645 3 3q22.1 phosphoinositide-3-kinase, regulatory subunit 4 protein-coding phosphoinositide-3-kinase, regulatory subunit 4 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 380 miR-503 hsa-miR-503-5p,hsa-miR-503-3p MIMAT0022925,MIMAT0002874 miRNA PIK3R4 autophagy down Homo sapiens 23622248 9606 30849 VPS15|p150 HGNC:8982|MIM:602610|Ensembl:ENSG00000196455|HPRD:04010|Vega:OTTHUMG00000159645 3 3q22.1 phosphoinositide-3-kinase, regulatory subunit 4 protein-coding phosphoinositide-3-kinase, regulatory subunit 4 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 381 miR-615 hsa-miR-615-5p,hsa-miR-615-3p MIMAT0004804,MIMAT0003283 miRNA FYCO1 autophagy down Homo sapiens 23622248 9606 79443 CATC2|CTRCT18|RUFY3|ZFYVE7 HGNC:14673|MIM:607182|Ensembl:ENSG00000163820|HPRD:06215|Vega:OTTHUMG00000133447 3 3p21.31 FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 382 miR-615 hsa-miR-615-5p,hsa-miR-615-3p MIMAT0004804,MIMAT0003283 miRNA FYCO1 autophagy down Homo sapiens 23622248 9606 79443 CATC2|CTRCT18|RUFY3|ZFYVE7 HGNC:14673|MIM:607182|Ensembl:ENSG00000163820|HPRD:06215|Vega:OTTHUMG00000133447 3 3p21.31 FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 383 miR-615 hsa-miR-615-5p,hsa-miR-615-3p MIMAT0004804,MIMAT0003283 miRNA UVRAG autophagy down Homo sapiens 23622248 9606 7405 DHTX|VPS38|p63 HGNC:12640|MIM:602493|HPRD:03929 11 11q13.5 UV radiation resistance associated protein-coding UV radiation resistance associated This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 384 miR-615 hsa-miR-615-5p,hsa-miR-615-3p MIMAT0004804,MIMAT0003283 miRNA UVRAG autophagy down Homo sapiens 23622248 9606 7405 DHTX|VPS38|p63 HGNC:12640|MIM:602493|HPRD:03929 11 11q13.5 UV radiation resistance associated protein-coding UV radiation resistance associated This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 385 miR-7 hsa-miR-7-5p,hsa-miR-7-1-3p,hsa-miR-7-2-3p MIMAT0000252,MIMAT0004553,MIMAT0004554 miRNA EGFR autophagy down Homo sapiens 22492316 9606 1956 ERBB|ERBB1|HER1|PIG61|mENA HGNC:3236|MIM:131550|Ensembl:ENSG00000146648|HPRD:00579|Vega:OTTHUMG00000023661 7 7p12 epidermal growth factor receptor protein-coding epidermal growth factor receptor Virus-mediated miR-7 upregulation depended on enhanced expression of the E2F1 protein. Ectopic expression of miR-7 suppressed cell viability and induced autophagy by inhibiting epidermal growth factor receptor (EGFR) expression. Our results suggest that oncolytic adenovirus induces autophagic cell death through an E2F1-miR-7-EGFR pathway in human cancer cells, providing a novel insight into the molecular mechanism of an anticancer virotherapy. 386 miR-877 hsa-miR-877-5p,hsa-miR-877-3p MIMAT0004949,MIMAT0004950 miRNA ATG4A autophagy down Homo sapiens 23622248 9606 115201 APG4A|AUTL2 HGNC:16489|MIM:300663|Ensembl:ENSG00000101844|HPRD:06455|Vega:OTTHUMG00000022176 X Xq22.1-q22.3 autophagy related 4A, cysteine peptidase protein-coding autophagy related 4A, cysteine peptidase This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 387 miR-877 hsa-miR-877-5p,hsa-miR-877-3p MIMAT0004949,MIMAT0004950 miRNA SQSTM1 autophagy down Homo sapiens 23622248 9606 8878 A170|OSIL|PDB3|ZIP3|p60|p62|p62B HGNC:11280|MIM:601530|Ensembl:ENSG00000161011|HPRD:03319|Vega:OTTHUMG00000150643 5 5q35 sequestosome 1 protein-coding sequestosome 1 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 388 miR-93 hsa-miR-93-5p,hsa-miR-93-3p MIMAT0000093,MIMAT0004509 miRNA FYCO1 autophagy down Homo sapiens 22135297 9606 79443 CATC2|CTRCT18|RUFY3|ZFYVE7 HGNC:14673|MIM:607182|Ensembl:ENSG00000163820|HPRD:06215|Vega:OTTHUMG00000133447 3 3p21.31 FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 389 miR-9-3p hsa-miR-9-3p MIMAT0000442 miRNA BECN1 autophagy up Homo sapiens medullary thyroid carcinoma cell 25487826 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related Post-miR-9-3p transfection array studies showed a significant global decline in autophagy gene expression (most notably in PIK3C3, mTOR, and LAMP-1). Autophagy gene mRNAs were generally overexpressed in sporadic (vs. hereditary MTC) and Beclin-1 overexpression was shown to correlate with residual disease. Autophagy is a tumor cell survival mechanism in MTC that when disabled, is of therapeutic advantage. Beclin-1 expression may be a useful prognostic biomarker of aggressive disease. 390 miR-9-3p hsa-miR-9-3p MIMAT0000442 miRNA LAMP1 autophagy down Homo sapiens medullary thyroid carcinoma cell 25487826 9606 3916 CD107a|LAMPA|LGP120 HGNC:6499|MIM:153330|Ensembl:ENSG00000185896|HPRD:01076|Vega:OTTHUMG00000017380 13 13q34 lysosomal-associated membrane protein 1 protein-coding lysosomal-associated membrane protein 1 Post-miR-9-3p transfection array studies showed a significant global decline in autophagy gene expression (most notably in PIK3C3, mTOR, and LAMP-1). Autophagy gene mRNAs were generally overexpressed in sporadic (vs. hereditary MTC) and Beclin-1 overexpression was shown to correlate with residual disease. Autophagy is a tumor cell survival mechanism in MTC that when disabled, is of therapeutic advantage. Beclin-1 expression may be a useful prognostic biomarker of aggressive disease. 391 miR-9-3p hsa-miR-9-3p MIMAT0000442 miRNA MTOR autophagy down Homo sapiens medullary thyroid carcinoma cell 25487826 9606 2475 FRAP|FRAP1|FRAP2|RAFT1|RAPT1 HGNC:3942|MIM:601231|Ensembl:ENSG00000198793|HPRD:03134|Vega:OTTHUMG00000002001 1 1p36.2 mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) Post-miR-9-3p transfection array studies showed a significant global decline in autophagy gene expression (most notably in PIK3C3, mTOR, and LAMP-1). Autophagy gene mRNAs were generally overexpressed in sporadic (vs. hereditary MTC) and Beclin-1 overexpression was shown to correlate with residual disease. Autophagy is a tumor cell survival mechanism in MTC that when disabled, is of therapeutic advantage. Beclin-1 expression may be a useful prognostic biomarker of aggressive disease. 392 miR-9-3p hsa-miR-9-3p MIMAT0000442 miRNA PIK3C3 autophagy down Homo sapiens medullary thyroid carcinoma cell 25487826 9606 5289 VPS34|hVps34 HGNC:8974|MIM:602609|HPRD:04009 18 18q12.3 phosphatidylinositol 3-kinase, catalytic subunit type 3 protein-coding phosphatidylinositol 3-kinase, catalytic subunit type 3 Post-miR-9-3p transfection array studies showed a significant global decline in autophagy gene expression (most notably in PIK3C3, mTOR, and LAMP-1). Autophagy gene mRNAs were generally overexpressed in sporadic (vs. hereditary MTC) and Beclin-1 overexpression was shown to correlate with residual disease. Autophagy is a tumor cell survival mechanism in MTC that when disabled, is of therapeutic advantage. Beclin-1 expression may be a useful prognostic biomarker of aggressive disease. 393 miR-95 hsa-miR-95-5p,hsa-miR-95-3p MIMAT0026473,MIMAT0000094 miRNA SUMF1 autophagy down Homo sapiens 25524633 9606 285362 AAPA3037|FGE HGNC:20376|MIM:607939|Ensembl:ENSG00000144455|HPRD:06399|Vega:OTTHUMG00000090269 3 3p26.1 sulfatase modifying factor 1 protein-coding sulfatase modifying factor 1 miR-95 depletes SUMF1 protein levels and suppresses sulfatase activity, causing the disruption of proteoglycan catabolism and lysosomal function. This blocks autophagy-mediated degradation,causing cytoplasmic accumulation of autophagosomes and autophagic substrates. 394 miR-98 hsa-miR-96-5p,hsa-miR-96-3p MIMAT0000095,MIMAT0004510 miRNA PIK3C3 autophagy down Homo sapiens 22135297 9606 5289 VPS34|hVps34 HGNC:8974|MIM:602609|HPRD:04009 18 18q12.3 phosphatidylinositol 3-kinase, catalytic subunit type 3 protein-coding phosphatidylinositol 3-kinase, catalytic subunit type 3 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 395 miR-98 hsa-miR-96-5p,hsa-miR-96-3p MIMAT0000095,MIMAT0004510 miRNA RB1CC1 autophagy down Homo sapiens 22135297 9606 9821 ATG17|CC1|FIP200|PPP1R131 HGNC:15574|MIM:606837|Ensembl:ENSG00000023287|HPRD:06019|Vega:OTTHUMG00000164268 8 8q11 RB1-inducible coiled-coil 1 protein-coding RB1-inducible coiled-coil 1 This autophagy associated entry comes from "T¨¹rei D1, F?ldv¨¢ri-Nagy L, Fazekas D, M¨®dos D. Autophagy Regulatory Network ¡ª A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy 2015; PMID:25635527;". 396 7SK http://lncrna.com/7SK/ lncRNA apoptosis down Homo sapiens embryonic kidney 25492483 9606 protein coding 7SK small nuclear RNA (snRNA) is a 331-333-bp non-coding RNA, which recruits HEXIM 1/2 protein to inhibit positive elongation factor b (P-TEFb) activity. Moreover, 7SK snRNA over-expression promoted apoptosis in cancerous cells. 397 ab074278 lncRNA EMP1 apoptosis Homo sapiens bladder cell 25165097 9606 2012 CL-20|EMP-1|TMP HGNC:3333|MIM:602333|Ensembl:ENSG00000134531|HPRD:11892|Vega:OTTHUMG00000168775 12 12p12.3 epithelial membrane protein 1 protein-coding epithelial membrane protein 1 We identified 32 lncRNAs with potential roles in disease progression. Focusing upon a promising candidate, we implicate upregulation of AB074278 in apoptosis avoidance and the maintenance of a proproliferative state in cancer through a potential interaction with EMP1, a tumor suppressor and a negative regulator of cell proliferation. 398 AF118081 lncRNA apoptosis Homo sapiens 16HBE cell 25050996 9606 Using quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR), lncRNA AF118081 was identified as the most significantly overexpressed lncRNA in 16HBE-T cells, lung cancer cells, and patient samples. Cell proliferation, colony formation, apoptosis, migration, and invasion were assayed in 16HBE-T cells following the knockdown of lncRNA AF118081 with small interfering RNA. 399 AFAP1-AS1 http://www.lncrnadb.org/afap1as/ lncRNA apoptosis down Homo sapiens Barrett's esophagus 23333711 9606 Its silencing by small interfering RNA inhibited proliferation and colony-forming ability, induced apoptosis, and reduced EAC cell migration and invasion without altering the expression of its protein-coding counterpart, AFAP1. 400 ANRIL http://lncrna.com/ANRIL/ lncRNA CDKN2B apoptosis down Homo sapiens prostate cancer cells 20729297 9606 1030 CDK4I|INK4B|MTS2|P15|TP15|p15INK4b HGNC:1788|MIM:600431|Ensembl:ENSG00000147883|HPRD:02696|Vega:OTTHUMG00000019691 9 9p21 cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) protein-coding cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) CDK inhibitory protein; C The antisense ncRNA ANRIL controls expression in the INK4A/ARF locus comprising the tumor-suppressor genes INK4n/ARF/INK4a, p16/CDKN2A and p15/CDKN2B, which regulate cell cycle progression and senescence. 401 ANRIL http://lncrna.com/ANRIL/ lncRNA CDKN2B apoptosis down Homo sapiens lung 25504755 9606 1030 CDK4I|INK4B|MTS2|P15|TP15|p15INK4b HGNC:1788|MIM:600431|Ensembl:ENSG00000147883|HPRD:02696|Vega:OTTHUMG00000019691 9 9p21 cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) protein-coding cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) LncRNA ANRIL was first found to be required for the PRC2 recruitment to and silencing of p15(INK4B), the expression of which is induced by the ATM-E2F1 signaling pathway. 402 ANRIL http://lncrna.com/ANRIL/ lncRNA E2F1 apoptosis Homo sapiens 23416462 9606 1869 E2F-1|RBAP1|RBBP3|RBP3 HGNC:3113|MIM:189971|Ensembl:ENSG00000101412|HPRD:01806|Vega:OTTHUMG00000032265 20 20q11.2 E2F transcription factor 1 protein-coding E2F transcription factor 1 Consistent with the results from the apoptosis assays, depletion of ANRIL resulted in an increase in the sensitivity of HCT116 p53+/+ cells to the treatment with neocarzinostatin (NCS), confirming that lowered levels of ANRIL in cells led to elevated apoptosis in the DNA damage response(DDR).In the present study, we demonstrate that one specific lncRNA, ANRIL, is transcriptionally up-regulated by the transcription factor E2F1 in an ATM-dependent manner following DNA damage, 403 ANRIL http://lncrna.com/ANRIL/ lncRNA KLF2 apoptosis down Homo sapiens lung 25504755 9606 10365 LKLF HGNC:6347|MIM:602016|Ensembl:ENSG00000127528|HPRD:03602|Vega:OTTHUMG00000182330 19 19p13.11 Kruppel-like factor 2 protein-coding Kruppel-like factor 2 In addition, taking advantage of loss-of-function experiments in NSCLC cells,we found that knockdown of ANRIL expression could impair cell proliferation and induce cell apoptosis both in vitro and vivo through silencing of KLF2 and P21 transcription. 404 ANRIL http://lncrna.com/ANRIL/ lncRNA RASA1 apoptosis down Homo sapiens 25501747 9606 5921 CM-AVM|CMAVM|GAP|PKWS|RASA|RASGAP|p120GAP|p120RASGAP HGNC:9871|MIM:139150|Ensembl:ENSG00000145715|HPRD:00745|Vega:OTTHUMG00000162605 5 5q13.3 RAS p21 protein activator (GTPase activating protein) 1 protein-coding RAS p21 protein activator (GTPase activating protein) 1 Here, we show that the exogenous and endogenous expression of an oncogenic form of small GTPase Ras (called oncogenic Ras) decrease the expression of lncRNA ANRIL (antisense non-coding RNA in the INK4 locus), which is involved in the regulation of cellular senescence 405 ANRIL http://lncrna.com/ANRIL/ lncRNA apoptosis Homo sapiens vascular smooth muscle cells 22382030 9606 ANRIL splicing variants play a role in coordinating tissue remodeling, by modulating the expression of genes involved in cell proliferation, apoptosis, extra-cellular matrix remodeling and inflammatory response to finally impact in the risk of cardiovascular disease and other pathologies. 406 ANRIL http://lncrna.com/ANRIL/ lncRNA apoptosis up Homo sapiens breast cancer cells 22487937 9606 Our results reveal that basal RNA expression levels as well as the changes in the lncRNA expression rates during genotoxic stress-induced apoptosis were cell-type and/or DNA-damaging agent-specific. Generally, we found that some of the RNA molecules (HOTAIR and MALAT1) are down-regulated while many of them (lincRNA-p21, GAS5, MEG3, ANRIL, and ncRNA-CCND1) are up-regulated and some others (TUG1, UCA1, and PANDA) not affected. 407 ANRIL http://lncrna.com/ANRIL/ lncRNA apoptosis Homo sapiens 23861667 9606 Here, we report on the molecular mechanisms through which ANRIL regulates target-genes in trans, leading to increased cell proliferation, increased cell adhesion and decreased apoptosis 408 ASLNC04080 lncRNA apoptosis Homo sapiens HEC-1-B cell 25695231 9606 Expression inhibition of lncRNA ASLNC04080 in HEC-1-B cells caused repression of cell proliferation, increased cell apoptosis, and G1 phase arrest. These results suggested a potential function of ASLNC04080 in endometrial carcinoma genesis and progression. 409 ASncmtRNAs http://www.lncrnadb.org/asncmtrnas/ lncRNA BIRC5 apoptosis down Homo sapiens 25100722 9606 332 API4|EPR-1 HGNC:593|MIM:603352|Ensembl:ENSG00000089685|HPRD:04520|Vega:OTTHUMG00000177505 17 17q25 baculoviral IAP repeat containing 5 protein-coding baculoviral IAP repeat containing 5 Down-regulation of survivin is at the translational level and is probably mediated by microRNAs generated by dicing of the double-stranded stem of the ASncmtRNAs, as suggested by evidence presented here, in which the ASncmtRNAs are bound to Dicer and knockdown of the ASncmtRNAs reduces reporter luciferase activity in a vector carrying the 3'-UTR of survivin mRNA. 410 ASncmtRNAs http://www.lncrnadb.org/asncmtrnas/ lncRNA DICER1 apoptosis Homo sapiens 25100722 9606 23405 DCR1|Dicer|HERNA|MNG1|RMSE2 HGNC:17098|MIM:606241|Ensembl:ENSG00000100697|HPRD:05875|Vega:OTTHUMG00000166134 14 14q32.13 dicer 1, ribonuclease type III protein-coding dicer 1, ribonuclease type III Down-regulation of survivin is at the translational level and is probably mediated by microRNAs generated by dicing of the double-stranded stem of the ASncmtRNAs, as suggested by evidence presented here, in which the ASncmtRNAs are bound to Dicer and knockdown of the ASncmtRNAs reduces reporter luciferase activity in a vector carrying the 3'-UTR of survivin mRNA. 411 BALR-2 lncRNA apoptosis Homo sapiens lymphoblastic cell 25681502 9606 Importantly, high expression of BALR-2 correlated with poor overall survival and diminished response to prednisone treatment. In line with a function for this lncRNA in regulating cell survival, BALR-2 knockdown led to reduced proliferation, increased apoptosis, and increased sensitivity to prednisolone treatment. Conversely, overexpression of BALR-2 led to increased cell growth and resistance to prednisone treatment. Interestingly, BALR-2 expression was repressed by prednisolone treatment and its knockdown led to upregulation of the glucocorticoid response pathway in both human and mouse B-cells. Together, these findings indicate that BALR-2 plays a functional role in the pathogenesis and/or clinical responsiveness of B-ALL and that altering the levels of particular lncRNAs may provide a future direction for therapeutic development. Implications: lncRNA expression has the potential to segregate the common subtypes of B-ALL, predict the cytogenetic subtype, and indicate prognosis. 412 BANCR http://lncrna.com/bancr/ lncRNA CDH1 apoptosis Homo sapiens lung 24655544 9606 999 Arc-1|CD324|CDHE|ECAD|LCAM|UVO HGNC:1748|MIM:192090|Ensembl:ENSG00000039068|HPRD:01885|Vega:OTTHUMG00000137561 16 16q22.1 cadherin 1, type 1, E-cadherin (epithelial) protein-coding cadherin 1, type 1, E-cadherin (epithelial) upregulation of BANCR expression promoted apoptosis.BANCR was found to play a key role in epithelial-mesenchymal transition (EMT) through the regulation of E-cadherin, N-cadherin and Vimentin expression of BANCR expression promoted apoptosis in comparison with that in control cells 413 BANCR http://lncrna.com/bancr/ lncRNA CDH2 apoptosis Homo sapiens lung 24655544 9606 1000 CD325|CDHN|CDw325|NCAD HGNC:1759|MIM:114020|Ensembl:ENSG00000170558|HPRD:00226|Vega:OTTHUMG00000059940 18 18q11.2 cadherin 2, type 1, N-cadherin (neuronal) protein-coding cadherin 2, type 1, N-cadherin (neuronal) upregulation of BANCR expression promoted apoptosis.BANCR was found to play a key role in epithelial-mesenchymal transition (EMT) through the regulation of E-cadherin, N-cadherin and Vimentin expression of BANCR expression promoted apoptosis in comparison with that in control cells 414 BANCR http://lncrna.com/bancr/ lncRNA MAP2K7 apoptosis Homo sapiens lung 25661343 9606 5609 JNKK2|MAPKK7|MEK|MEK 7|MKK7|PRKMK7|SAPKK-4|SAPKK4 HGNC:6847|MIM:603014|Ensembl:ENSG00000076984|Vega:OTTHUMG00000137368 19 19p13.3-p13.2 mitogen-activated protein kinase kinase 7 protein-coding mitogen-activated protein kinase kinase 7 We further found that MAPK pathways were involved in the BANCR-mediated cell proliferation and migration of LC. Moreover, BANCR was found to regulate LC proliferation and migration via not ERK MAPK, but p41 MAPK and JNK inactivations. 415 BANCR http://lncrna.com/bancr/ lncRNA MAPK11 apoptosis Homo sapiens lung 25661343 9606 5600 P38B|P38BETA2|PRKM11|SAPK2|SAPK2B|p38-2|p38Beta HGNC:6873|MIM:602898|Ensembl:ENSG00000185386|HPRD:04208|Vega:OTTHUMG00000150226 22 22q13.33 mitogen-activated protein kinase 11 protein-coding mitogen-activated protein kinase 11 We further found that MAPK pathways were involved in the BANCR-mediated cell proliferation and migration of LC. Moreover, BANCR was found to regulate LC proliferation and migration via not ERK MAPK, but p39 MAPK and JNK inactivations. 416 BANCR http://lncrna.com/bancr/ lncRNA MAPK8 apoptosis Homo sapiens lung 25661343 9606 5599 JNK|JNK-46|JNK1|JNK1A2|JNK21B1/2|PRKM8|SAPK1|SAPK1c HGNC:6881|MIM:601158|Ensembl:ENSG00000107643|HPRD:03100|Vega:OTTHUMG00000018172 10 10q11.22 mitogen-activated protein kinase 8 protein-coding mitogen-activated protein kinase 8 We further found that MAPK pathways were involved in the BANCR-mediated cell proliferation and migration of LC. Moreover, BANCR was found to regulate LC proliferation and migration via not ERK MAPK, but p38 MAPK and JNK inactivations. 417 BANCR http://lncrna.com/bancr/ lncRNA MAPK9 apoptosis Homo sapiens lung 25661343 9606 5601 JNK-55|JNK2|JNK2A|JNK2ALPHA|JNK2B|JNK2BETA|PRKM9|SAPK|SAPK1a|p54a|p54aSAPK HGNC:6886|MIM:602896|Ensembl:ENSG00000050748|HPRD:04206|Vega:OTTHUMG00000130934 5 5q35 mitogen-activated protein kinase 9 protein-coding mitogen-activated protein kinase 9 We further found that MAPK pathways were involved in the BANCR-mediated cell proliferation and migration of LC. Moreover, BANCR was found to regulate LC proliferation and migration via not ERK MAPK, but p40 MAPK and JNK inactivations. 418 BANCR http://lncrna.com/bancr/ lncRNA VIM apoptosis Homo sapiens lung 24655544 9606 7431 CTRCT30|HEL113 HGNC:12692|MIM:193060|Ensembl:ENSG00000026025|HPRD:01899|Vega:OTTHUMG00000017744 10 10p13 vimentin protein-coding vimentin upregulation of BANCR expression promoted apoptosis.BANCR was found to play a key role in epithelial-mesenchymal transition (EMT) through the regulation of E-cadherin, N-cadherin and Vimentin expression of BANCR expression promoted apoptosis in comparison with that in control cells 419 beta2.7 http://lncrna.com/beta27rna/ lncRNA apoptosis Homo sapiens 17540903 9606 we found that human cytomegalovirus infection protected cells from rotenone-induced apoptosis, a protection mediated by a 2.7-kilobase virally encoded RNA (beta2.7). During infection, beta2.7 RNA interacted with complex I and prevented the relocalization of the essential subunit genes associated with retinoid/interferon-induced mortality-19, in response to apoptotic stimuli. 420 CADM1-AS1 lncRNA CADM1 apoptosis Homo sapiens renal cell 25031695 9606 23705 BL2|IGSF4|IGSF4A|NECL2|Necl-2|RA175|ST17|SYNCAM|TSLC1|sTSLC-1|sgIGSF|synCAM1 HGNC:5951|MIM:605686|Ensembl:ENSG00000182985|HPRD:05746|Vega:OTTHUMG00000168202 11 11q23.2 cell adhesion molecule 1 protein-coding cell adhesion molecule 1 Functional experiments demonstrated markedly enhanced ability of growth and migration, and reduced apoptotic rate in CADM1-AS1 knocking down in 786-O cells. Conversely, overexpression of CADM1-AS1 showed a significant decrease in growth and migration, along with an increase in apoptotic rate in ACHN cells. In conclusion, our data demonstrated CADM1-AS1 is a new tumor suppressor in ccRCC which regulates cell proliferation, apoptosis and migration via the expression pattern of "CADM1-AS1/CADM1 mRNA gene pairs". CADM1-AS1 may be a potential biomarker and therapeutic target in patients with ccRCC. 421 CARLo-5 http://lncrna.com/ccat1/ lncRNA MAPK1 apoptosis up Homo sapiens gastric cancer cell 25674211 9606 5594 ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK HGNC:6871|MIM:176948|Ensembl:ENSG00000100030|HPRD:01496|Vega:OTTHUMG00000030508 22 22q11.21 mitogen-activated protein kinase 1 protein-coding mitogen-activated protein kinase 1 Knockdown of CARLo-5 in gastric cancer cell lines significantly inhibited the cell proliferation via inducing G0/G1 cell-cycle arrest and apoptosis. Furthermore, ERK/MAPK pathway was found to be inactivated in the gastric cells after CARLo-5 knockdown. These results indicated that CARLo-5 might serve as a pro-oncogenic lncRNA that promotes proliferation of gastric cancer and activates the ERK/MAPK pathway. 422 cbr3-as1 http://www.ncbi.nlm.nih.gov/gene/term=naPINK1 lncRNA PINK1 apoptosis Homo sapiens neuronal cells 17362513 9606 65018 BRPK|PARK6 HGNC:14581|MIM:608309|Ensembl:ENSG00000158828|HPRD:10514|Vega:OTTHUMG00000002841 1 1p36 PTEN induced putative kinase 1 protein-coding PTEN induced putative kinase 1 PTEN-induced putative kin PINK1 inhibits mitochondrial cytochrome c release, attenuating the general apoptosis machinery. The observation of concordant regulation of svPINK1 and naPINK1 during in vivo mitochondrial biogenesis was confirmed using RNAi, where selective targeting of naPINK1 results in loss of the PINK1 splice variant in neuronal cell lines. 423 CHRF http://lncrna.com/chrf/ lncRNA MYD88 apoptosis Homo sapiens cardiac 24557880 9606 4615 MYD88D HGNC:7562|MIM:602170|Ensembl:ENSG00000172936|HPRD:03703|Vega:OTTHUMG00000131083 3 3p22 myeloid differentiation primary response 88 protein-coding myeloid differentiation primary response 88 In the animal model, enforced expression of CHRF increased the apoptosis of cardiomyocytes.CHRF is able to directly bind to miR-489 and regulate Myd88 expression and hypertrophy. 424 DQ786227 http://lncrna.com/dq786227/ lncRNA apoptosis Homo sapiens lung 24084393 9606 Silencing of lncRNA-DQ786227 expression in malignant transformed BEAS-2B cells led to inhibition of cell proliferation and colony formation, and increased apoptosis. 425 EBER1(EBV) http://www.lncrnadb.org/EBER1andEBER2RNAs/ lncRNA BCL2 apoptosis down Homo sapiens BL cells 19886912 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 In BL cells, EBERs bind the double-stranded RNA-activated protein kinase PKR,inhibit its phosphorylation, and thereby prevent IFN-alpha-mediated apoptosis. 426 EBER1(EBV) http://www.lncrnadb.org/EBER1andEBER2RNAs/ lncRNA PRKRA apoptosis down Homo sapiens 16160154 9606 8575 DYT16|PACT|RAX HGNC:9438|MIM:603424|Ensembl:ENSG00000180228|HPRD:04573|Vega:OTTHUMG00000132576 2 2q31.2 protein kinase, interferon-inducible double stranded RNA dependent activator protein-coding protein kinase, interferon-inducible double stranded RNA dependent activator EBER bound double-stranded RNA-dependent protein kinase R (PKR), an interferon-inducible serine/threonine kinase, and abrogated its kinase activity. 427 EBER1(EBV) http://www.lncrnadb.org/EBER1andEBER2RNAs/ lncRNA PRKRA apoptosis down Homo sapiens BL cells 19886912 9606 8575 DYT16|PACT|RAX HGNC:9438|MIM:603424|Ensembl:ENSG00000180228|HPRD:04573|Vega:OTTHUMG00000132576 2 2q31.2 protein kinase, interferon-inducible double stranded RNA dependent activator protein-coding protein kinase, interferon-inducible double stranded RNA dependent activator In BL cells, EBERs bind the double-stranded RNA-activated protein kinase PKR,inhibit its phosphorylation, and thereby prevent IFN-alpha-mediated apoptosis. 428 fas http://www.valadkhanlab.org/web/cgi-bin/output_1.cgi?name=FAS&genome=h lncRNA apoptosis Homo sapiens leukaemia cells 9375749 9606 These findings suggest that the presence or absence of FAP-1 mRNA expression did not always correlate with relative sensitivity of Fas-mediated growth inhibition. Furthermore, it is assumed that leukaemia/lymphoma cells could possess structural or functional defects of Fas or Fas-associated proteins resulting in the failure to trigger apoptotic cell death. 429 FaS-aS1 lncRNA RBM5 apoptosis down Homo sapiens lymphomas cell 24811343 9606 10181 G15|LUCA15|RMB5 HGNC:9902|MIM:606884|Ensembl:ENSG00000003756|HPRD:06052|Vega:OTTHUMG00000156785 3 3p21.3 RNA binding motif protein 5 protein-coding RNA binding motif protein 5 We found that the alternative splicing of Fas in lymphomas is tightly regulated by a long-noncoding RNA corresponding to an antisense transcript of Fas (FAS-AS1). Levels of FAS-AS1 correlate inversely with production of sFas, and FAS-AS1 binding to the RBM5 inhibits RBM5-mediated exon 6 skipping. 430 fmr1-as1 http://www.genenames.org/data/hgnc_data.php?hgnc_id=39081 lncRNA apoptosis Homo sapiens brain 18213394 9606 FMR4 markedly affected human cell proliferation in vitro; siRNAs knockdown of FMR4 resulted in alterations in the cell cycle and increased apoptosis, while the overexpression of FMR4 caused an increase in cell proliferation. 431 GAS5 http://lncrna.com/GAS5/ lncRNA BIRC3 apoptosis down Homo sapiens prostate cancer cells 10647931 9606 330 AIP1|API2|CIAP2|HAIP1|HIAP1|MALT2|MIHC|RNF49|c-IAP2 HGNC:591|MIM:601721|Ensembl:ENSG00000023445|HPRD:03426|Vega:OTTHUMG00000167324 11 11q22 baculoviral IAP repeat containing 3 protein-coding baculoviral IAP repeat containing 3 In contrast to SRA, GAS5 functions as a "riborepressor": the ncRNA interacts with the DNA binding domain of the glucocorticoid receptors, thus competing with the glucocorticoid response elements in the genome for binding to these receptors. This suppresses the induction of several responsive genes including cellular inhibitor of apoptosis 2 (cIAP2) and ultimately sensitizes cells to apoptosis 432 GAS5 http://lncrna.com/GAS5/ lncRNA BIRC3 apoptosis down Homo sapiens 23383264 9606 330 AIP1|API2|CIAP2|HAIP1|HIAP1|MALT2|MIHC|RNF49|c-IAP2 HGNC:591|MIM:601721|Ensembl:ENSG00000023445|HPRD:03426|Vega:OTTHUMG00000167324 11 11q22 baculoviral IAP repeat containing 3 protein-coding baculoviral IAP repeat containing 3 We found that levels of the GAS5 transcript were elevated owing to prolonged decay rates in response to UPF1 depletion, and consequently the apoptosis-related genes, cIAP2 and SGK1, were down-regulated. In addition, serum starvation also increased the transcript levels of GAS5 because of prolonged decay rates, and conversely decreased levels of cIAP2 and SGK1 mRNA. 433 GAS5 http://lncrna.com/GAS5/ lncRNA CDKN1A apoptosis Homo sapiens gastric 24884417 9606 1026 CAP20|CDKN1|CIP1|MDA-6|P21|SDI1|WAF1|p21CIP1 HGNC:1784|MIM:116899|Ensembl:ENSG00000124762|HPRD:00298|Vega:OTTHUMG00000014603 6 6p21.2 cyclin-dependent kinase inhibitor 1A (p21, Cip1) protein-coding cyclin-dependent kinase inhibitor 1A (p21, Cip1) Ectopic expression of GAS5 was demonstrated to decrease gastric cancer cell proliferation and induce apoptosis in vitro and in vivo, while downregulation of endogenous GAS5 could promote cell proliferation. Finally, we found that GAS5 could influence gastric cancer cells proliferation, partly via regulating E2F1 and P21 expression. 434 GAS5 http://lncrna.com/GAS5/ lncRNA E2F1 apoptosis Homo sapiens gastric 24884417 9606 1869 E2F-1|RBAP1|RBBP3|RBP3 HGNC:3113|MIM:189971|Ensembl:ENSG00000101412|HPRD:01806|Vega:OTTHUMG00000032265 20 20q11.2 E2F transcription factor 1 protein-coding E2F transcription factor 1 Ectopic expression of GAS5 was demonstrated to decrease gastric cancer cell proliferation and induce apoptosis in vitro and in vivo, while downregulation of endogenous GAS5 could promote cell proliferation. Finally, we found that GAS5 could influence gastric cancer cells proliferation, partly via regulating E2F1 and P21 expression. 435 GAS5 http://lncrna.com/GAS5/ lncRNA MTOR apoptosis Homo sapiens breast 24789445 9606 2475 FRAP|FRAP1|FRAP2|RAFT1|RAPT1 HGNC:3942|MIM:601231|Ensembl:ENSG00000198793|HPRD:03134|Vega:OTTHUMG00000002001 1 1p36.2 mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) GAS5 lncRNA promoted the apoptosis of triple-negative and oestrogen receptor-positive cells but only dual PI3K/mTOR inhibition was able to enhance GAS5 levels in all cell types. 436 GAS5 http://lncrna.com/GAS5/ lncRNA PIK3CA apoptosis Homo sapiens breast 24789445 9606 5290 CLOVE|CWS5|MCAP|MCM|MCMTC|PI3K|p110-alpha HGNC:8975|MIM:171834|HPRD:01382 3 3q26.3 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha protein-coding phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha GAS5 lncRNA promoted the apoptosis of triple-negative and oestrogen receptor-positive cells but only dual PI3K/mTOR inhibition was able to enhance GAS5 levels in all cell types. 437 Gas5 http://lncrna.com/GAS5/ lncRNA SCTR apoptosis Homo sapiens 25377354 9606 6344 SR HGNC:10608|MIM:182098|Ensembl:ENSG00000080293|HPRD:01628|Vega:OTTHUMG00000131407 2 2q14.1 secretin receptor protein-coding secretin receptor Here we report the molecular requirements for the recognition of steroid receptors (SRs) by the lincRNA growth arrest-specific 5 (Gas5), which regulates steroid-mediated transcriptional regulation, growth arrest and apoptosis. 438 GAS5 http://lncrna.com/GAS5/ lncRNA SGK1 apoptosis down Homo sapiens 23383264 9606 6446 SGK HGNC:10810|MIM:602958|Ensembl:ENSG00000118515|HPRD:04264|Vega:OTTHUMG00000015613 6 6q23 serum/glucocorticoid regulated kinase 1 protein-coding serum/glucocorticoid regulated kinase 1 We found that levels of the GAS5 transcript were elevated owing to prolonged decay rates in response to UPF1 depletion, and consequently the apoptosis-related genes, cIAP2 and SGK1, were down-regulated. In addition, serum starvation also increased the transcript levels of GAS5 because of prolonged decay rates, and conversely decreased levels of cIAP2 and SGK1 mRNA. 439 GAS5 http://lncrna.com/GAS5/ lncRNA apoptosis Homo sapiens T-cell lines 18354083 9606 Overexpression of GAS5 causes both an increase in apoptosis and a reduction in the rate of progression through the cell-cycle. 440 GAS5 http://lncrna.com/GAS5/ lncRNA apoptosis Homo sapiens breast cancer cells 18836484 9606 GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer. 441 GAS5 http://lncrna.com/GAS5/ lncRNA apoptosis up Homo sapiens breast cancer cells 22487937 9606 Our results reveal that basal RNA expression levels as well as the changes in the lncRNA expression rates during genotoxic stress-induced apoptosis were cell-type and/or DNA-damaging agent-specific. Generally, we found that some of the RNA molecules (HOTAIR and MALAT1) are down-regulated while many of them (lincRNA-p21, GAS5, MEG3, ANRIL, and ncRNA-CCND1) are up-regulated and some others (TUG1, UCA1, and PANDA) not affected. 442 GAS5 http://lncrna.com/GAS5/ lncRNA apoptosis Homo sapiens Renal cell carcinoma 23621190 9606 Furthermore, using functional expression cloning, we found that overexpression of GAS5 in A498 cells inhibited cell proliferation, induced cell apoptosis and arrested cell cycling. 443 GAS5 http://lncrna.com/GAS5/ lncRNA apoptosis Homo sapiens prostate 23676682 9606 Prostate cell lines were transfected with GAS5-encoding plasmids or GAS5 siRNAs, and cell survival was assessed. Basal apoptosis increased, and cell survival decreased 444 GAS5 http://lncrna.com/GAS5/ lncRNA apoptosis Homo sapiens NSCLC 24357161 9606 7157 TP53|BCC7|LFS1|TRP53 HGNC:11998|Ensembl:ENSG00000141510|HPRD:01859|MIM:191170|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein coding tumor protein p53 Furthermore, GAS5 overexpression increased tumor cell growth arrest and induced apoptosis in vitro and in vivo.we found that ectopic expression of GAS5 significantly up-regulated p53 expression and down-regulated transcription factor E2F1 expression. 445 H19 http://lncrna.com/H19/ lncRNA ABL1 apoptosis down Homo sapiens leukemia 24685695 9606 25 ABL|JTK7|bcr/abl|c-ABL|c-ABL1|p150|v-abl HGNC:76|MIM:189980|Ensembl:ENSG00000097007|HPRD:01809|Vega:OTTHUMG00000020813 9 9q34.1 ABL proto-oncogene 1, non-receptor tyrosine kinase protein-coding ABL proto-oncogene 1, non-receptor tyrosine kinase Silencing H19 expression sensitized leukemic cells to undergo imatinib-induced apoptosis and inhibited Bcr-Abl-induced tumor growth. Furthermore, H19 was shown to be regulated by c-Myc in Bcr-Abl-expressing cells. 446 H19 http://lncrna.com/H19/ lncRNA BCR apoptosis down Homo sapiens leukemia 24685695 9606 613 ALL|BCR1|CML|D22S11|D22S662|PHL HGNC:1014|MIM:151410|Ensembl:ENSG00000186716|HPRD:01044|Vega:OTTHUMG00000150655 22 22q11.23 breakpoint cluster region protein-coding breakpoint cluster region Silencing H19 expression sensitized leukemic cells to undergo imatinib-induced apoptosis and inhibited Bcr-Abl-induced tumor growth. Furthermore, H19 was shown to be regulated by c-Myc in Bcr-Abl-expressing cells. 447 H19 http://lncrna.com/H19/ lncRNA DUSP5 apoptosis down Homo sapiens JAR cells 23711233 9606 1847 DUSP|HVH3 HGNC:3071|MIM:603069|Ensembl:ENSG00000138166|HPRD:04349|Vega:OTTHUMG00000019040 10 10q25 dual specificity phosphatase 5 protein-coding dual specificity phosphatase 5 H19 knockdown inhibited apoptosis and proliferation of JAR cells, but had no significant impact on cell invasion. In addition, H19 knockdown resulted in significant upregulation of HES-1 and DUSP5 expression, but not IGF2 expression in JAR cells. 448 H19 http://lncrna.com/H19/ lncRNA HES1 apoptosis down Homo sapiens JAR cells 23711233 9606 3280 HES-1|HHL|HRY|bHLHb39 HGNC:5192|MIM:139605|Ensembl:ENSG00000114315|HPRD:00770|Vega:OTTHUMG00000155984 3 3q28-q29 hes family bHLH transcription factor 1 protein-coding hes family bHLH transcription factor 1 H19 knockdown inhibited apoptosis and proliferation of JAR cells, but had no significant impact on cell invasion. In addition, H19 knockdown resulted in significant upregulation of HES-1 and DUSP5 expression, but not IGF2 expression in JAR cells. 449 H19 http://lncrna.com/H19/ lncRNA MYC apoptosis down Homo sapiens leukemia 24685695 9606 4609 MRTL|MYCC|bHLHe39|c-Myc HGNC:7553|MIM:190080|Ensembl:ENSG00000136997|HPRD:01818|Vega:OTTHUMG00000128475 8 8q24.21 v-myc avian myelocytomatosis viral oncogene homolog protein-coding v-myc avian myelocytomatosis viral oncogene homolog Silencing H19 expression sensitized leukemic cells to undergo imatinib-induced apoptosis and inhibited Bcr-Abl-induced tumor growth. Furthermore, H19 was shown to be regulated by c-Myc in Bcr-Abl-expressing cells. 450 h19 http://lncrna.com/H19/ lncRNA TP53 apoptosis down Homo sapiens gastric cancer cells 22776265 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 antigen NY-CO-13; cellula Ectopic expression of H19 increased cell proliferation, whereas H19 siRNA treatment contributed to cell apoptosis in AGS cell line.We further verified that H19 was associated with p53, and that this association resulted in partial p53 inactivation 451 HIF1A-AS1 lncRNA BCL2 apoptosis up Homo sapiens vascular 25550800 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Regulation of apoptosis by long non-coding RNA HIF1A-AS1 in VSMCs: implications for TAA pathogenesis. We also found that transfection of cells with HIF1a-AS1 siRNA decreased the expression of caspase3 and caspase8 and increased the expression of Bcl2, and protected PA-induced cell apoptosis in VSMCs. 452 HIF1A-AS1 lncRNA CASP3 apoptosis down Homo sapiens vascular 25550800 9606 836 CPP32|CPP32B|SCA-1 HGNC:1504|MIM:600636|Ensembl:ENSG00000164305|HPRD:02799|Vega:OTTHUMG00000133681 4 4q34 caspase 3, apoptosis-related cysteine peptidase protein-coding caspase 3, apoptosis-related cysteine peptidase Regulation of apoptosis by long non-coding RNA HIF1A-AS1 in VSMCs: implications for TAA pathogenesis. We also found that transfection of cells with HIF1a-AS1 siRNA decreased the expression of caspase3 and caspase8 and increased the expression of Bcl2, and protected PA-induced cell apoptosis in VSMCs. 453 HIF1A-AS1 lncRNA CASP8 apoptosis down Homo sapiens vascular 25550800 9606 841 ALPS2B|CAP4|Casp-8|FLICE|MACH|MCH5 HGNC:1509|MIM:601763|Ensembl:ENSG00000064012|HPRD:03459|Vega:OTTHUMG00000132821 2 2q33-q34 caspase 8, apoptosis-related cysteine peptidase protein-coding caspase 8, apoptosis-related cysteine peptidase Regulation of apoptosis by long non-coding RNA HIF1A-AS1 in VSMCs: implications for TAA pathogenesis. We also found that transfection of cells with HIF1a-AS1 siRNA decreased the expression of caspase3 and caspase8 and increased the expression of Bcl2, and protected PA-induced cell apoptosis in VSMCs. 454 HIF1A-AS1 lncRNA SMARCA4 apoptosis up Homo sapiens smooth muscle cell 24875884 9606 6597 BAF190|BAF190A|BRG1|MRD16|RTPS2|SNF2|SNF2L4|SNF2LB|SWI2|hSNF2b HGNC:11100|MIM:603254|Ensembl:ENSG00000127616|HPRD:04459|Vega:OTTHUMG00000169272 19 19p13.2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 protein-coding SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 BRG1 expression is increased in thoracic aortic aneurysms and regulates proliferation and apoptosis of vascular smooth muscle cells through the long non-coding RNA HIF1A-AS1 in vitro. 455 HOTAIR http://lncrna.com/hotair/ lncRNA AKT1 apoptosis down Homo sapiens breast 25613518 9606 207 AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA HGNC:391|MIM:164730|Ensembl:ENSG00000142208|HPRD:01261|Vega:OTTHUMG00000170795 14 14q32.32 v-akt murine thymoma viral oncogene homolog 1 protein-coding v-akt murine thymoma viral oncogene homolog 1 Treatment of MCF-7 cells with calycosin or genistein resulted in decreased phosphorylation of Akt, and decreased expression of its downstream target, HOTAIR. 456 HOTAIR http://lncrna.com/hotair/ lncRNA CDKN1A apoptosis down Homo sapiens lung 24155936 9606 1026 CAP20|CDKN1|CIP1|MDA-6|P21|SDI1|WAF1|p21CIP1 HGNC:1784|MIM:116899|Ensembl:ENSG00000124762|HPRD:00298|Vega:OTTHUMG00000014603 6 6p21.2 cyclin-dependent kinase inhibitor 1A (p21, Cip1) protein-coding cyclin-dependent kinase inhibitor 1A (p21, Cip1) We also found that the siRNA/HOTAIR1-mediated chemosensivity enhancement was associated with inhibition of cell proliferation, induction of G0/G1 cell-cycle arrest and apoptosis enhancement through regulation of p21(WAF1/CIP1) (p21) expression. 457 HOTAIR http://lncrna.com/hotair/ lncRNA CDKN1A apoptosis down Homo sapiens cervical 25547435 9606 1026 CAP20|CDKN1|CIP1|MDA-6|P21|SDI1|WAF1|p21CIP1 HGNC:1784|MIM:116899|Ensembl:ENSG00000124762|HPRD:00298|Vega:OTTHUMG00000014603 6 6p21.2 cyclin-dependent kinase inhibitor 1A (p21, Cip1) protein-coding cyclin-dependent kinase inhibitor 1A (p21, Cip1) In vitro,upregulation of HOTAIR inhibited apoptosis and promoted cellular proliferation,cell cycle progression, migration, and invasion; Moreover, we proved that HOTAIR execute its functions mainly through inhibiting the p21 expression. 458 HOTAIR http://lncrna.com/hotair/ lncRNA CREBBP apoptosis down Homo sapiens breast 23375982 9606 1387 CBP|KAT3A|RSTS HGNC:2348|MIM:600140|Ensembl:ENSG00000005339|HPRD:02534|Vega:OTTHUMG00000129431 16 16p13.3 CREB binding protein protein-coding CREB binding protein Herein, we demonstrated that HOTAIR is crucial for cell growth and viability and its knockdown induced apoptosis in breast cancer cells. We also demonstrated that HOTAIR is transcriptionally induced by estradiol (E2). Its promoter contains multiple functional estrogen response elements (EREs). Estrogen receptors (ERs) along with various ER coregulators such as histone methylases MLL1 (mixed lineage leukemia 1) and MLL3 and CREB-binding protein/p300 bind to the promoter of HOTAIR in an E2-dependent manner. 459 HOTAIR http://lncrna.com/hotair/ lncRNA EP300 apoptosis down Homo sapiens breast 23375982 9606 2033 KAT3B|RSTS2|p300 HGNC:3373|MIM:602700|Ensembl:ENSG00000100393|HPRD:04078|Vega:OTTHUMG00000150937 22 22q13.2 E1A binding protein p300 protein-coding E1A binding protein p300 Herein, we demonstrated that HOTAIR is crucial for cell growth and viability and its knockdown induced apoptosis in breast cancer cells. We also demonstrated that HOTAIR is transcriptionally induced by estradiol (E2). Its promoter contains multiple functional estrogen response elements (EREs). Estrogen receptors (ERs) along with various ER coregulators such as histone methylases MLL1 (mixed lineage leukemia 1) and MLL3 and CREB-binding protein/p300 bind to the promoter of HOTAIR in an E2-dependent manner. 460 HOTAIR http://lncrna.com/hotair/ lncRNA ESR1 apoptosis down Homo sapiens breast 23375982 9606 2099 ER|ESR|ESRA|ESTRR|Era|NR3A1 HGNC:3467|MIM:133430|Ensembl:ENSG00000091831|HPRD:00589|Vega:OTTHUMG00000016103 6 6q25.1 estrogen receptor 1 protein-coding estrogen receptor 1 Herein, we demonstrated that HOTAIR is crucial for cell growth and viability and its knockdown induced apoptosis in breast cancer cells. We also demonstrated that HOTAIR is transcriptionally induced by estradiol (E2). Its promoter contains multiple functional estrogen response elements (EREs). Estrogen receptors (ERs) along with various ER coregulators such as histone methylases MLL1 (mixed lineage leukemia 1) and MLL3 and CREB-binding protein/p300 bind to the promoter of HOTAIR in an E2-dependent manner. 461 HOTAIR http://lncrna.com/hotair/ lncRNA EZH2 apoptosis Homo sapiens Panc1 and L3.6pL cells 22614017 9606 2146 ENX-1|ENX1|EZH1|EZH2b|KMT6|KMT6A|WVS|WVS2 HGNC:3527|MIM:601573|Ensembl:ENSG00000106462|HPRD:03342|Vega:OTTHUMG00000158973 7 7q35-q36 enhancer of zeste 2 polycomb repressive complex 2 subunit protein-coding enhancer of zeste 2 polycomb repressive complex 2 subunit HOTAIR knockdown in Panc1 and L3.6pL pancreatic cancer cells that overexpress this lincRNA decreased cell proliferation, altered cell cycle progression and induced apoptosis Analysis of selected genes suppressed by HOTAIR in Panc1 and L3.6pL cells showed by knockdown of EZH2 462 HOTAIR http://lncrna.com/hotair/ lncRNA HOXA5 apoptosis down Homo sapiens lung 24103700 9606 3202 HOX1|HOX1.3|HOX1C HGNC:5106|MIM:142952|Ensembl:ENSG00000106004|HPRD:00840|Vega:OTTHUMG00000023214 7 7p15.2 homeobox A5 protein-coding homeobox A5 Taken together, these results indicate that inhibition of HOTAIR induces NSCLC cells apoptosis, but has no effect on cell vitality. Our findings indicate that HOTAIR is significantly up-regulated in NSCLC tissues, and regulates NSCLC cell invasion and metastasis, partially via the down-regulation of HOXA5. 463 HOTAIR http://lncrna.com/hotair/ lncRNA KMT2A apoptosis down Homo sapiens breast 23375982 9606 4297 ALL-1|CXXC7|HRX|HTRX1|MLL|MLL/GAS7|MLL1|MLL1A|TET1-MLL|TRX1|WDSTS HGNC:7132|MIM:159555|Ensembl:ENSG00000118058|HPRD:01162|Vega:OTTHUMG00000166337 11 11q23 lysine (K)-specific methyltransferase 2A protein-coding lysine (K)-specific methyltransferase 2A Herein, we demonstrated that HOTAIR is crucial for cell growth and viability and its knockdown induced apoptosis in breast cancer cells. We also demonstrated that HOTAIR is transcriptionally induced by estradiol (E2). Its promoter contains multiple functional estrogen response elements (EREs). Estrogen receptors (ERs) along with various ER coregulators such as histone methylases MLL1 (mixed lineage leukemia 1) and MLL3 and CREB-binding protein/p300 bind to the promoter of HOTAIR in an E2-dependent manner. 464 HOTAIR http://lncrna.com/hotair/ lncRNA KMT2C apoptosis down Homo sapiens breast 23375982 9606 58508 HALR|MLL3 HGNC:13726|MIM:606833|Ensembl:ENSG00000055609|HPRD:06016|Vega:OTTHUMG00000150553 7 7q36.1 lysine (K)-specific methyltransferase 2C protein-coding lysine (K)-specific methyltransferase 2C Herein, we demonstrated that HOTAIR is crucial for cell growth and viability and its knockdown induced apoptosis in breast cancer cells. We also demonstrated that HOTAIR is transcriptionally induced by estradiol (E2). Its promoter contains multiple functional estrogen response elements (EREs). Estrogen receptors (ERs) along with various ER coregulators such as histone methylases MLL1 (mixed lineage leukemia 1) and MLL3 and CREB-binding protein/p300 bind to the promoter of HOTAIR in an E2-dependent manner. 465 HOTAIR http://lncrna.com/hotair/ lncRNA PTEN apoptosis down Homo sapiens laryngeal squamous cell cancer 23141928 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog SiRNA-mediated knockdown of HOTAIR led to reduced invasion and increased apoptosis of Hep-2 cells in vitro and significantly reduced growth of LSCC xenograft tumors in mice. Moreover, PTEN methylation was significantly reduced in Hep-2 cells depleted of HOTAIR. 466 HOTAIR http://lncrna.com/hotair/ lncRNA RBM38 apoptosis down Homo sapiens hepatocellular carcinoma 24663081 9606 55544 HSRNASEB|RNPC1|SEB4B|SEB4D|dJ800J21.2 HGNC:15818|MIM:612428|Ensembl:ENSG00000132819|HPRD:15268|Vega:OTTHUMG00000032820 20 20q13.31 RNA binding motif protein 38 protein-coding RNA binding motif protein 38 Long non-coding RNA HOTAIR exerts regulatory functions in various biological processes in cancer cells, such as proliferation, apoptosis, mobility, and invasion. HOTAIR could promote migration and invasion of HCC cells by inhibiting RBM38. 467 HOTAIR http://lncrna.com/hotair/ lncRNA TNF apoptosis down Homo sapiens hepatocellular carcinoma cells 21327457 9606 7124 DIF|TNF-alpha|TNFA|TNFSF2 HGNC:11892|MIM:191160|Ensembl:ENSG00000232810|HPRD:01855|Vega:OTTHUMG00000031194 6 6p21.3 tumor necrosis factor protein-coding tumor necrosis factor APC1 protein; TNF, macrop SiRNA suppression of HOTAIR in a liver cancer cell line reduced cell viability and cell invasion, sensitized TNF-a induced apoptosis, and increased the chemotherapeutic sensitivity of cancer cells to cisplatin and doxorubicin. 468 HOTAIR http://lncrna.com/hotair/ lncRNA apoptosis down Homo sapiens breast cancer cells 22487937 9606 Our results reveal that basal RNA expression levels as well as the changes in the lncRNA expression rates during genotoxic stress-induced apoptosis were cell-type and/or DNA-damaging agent-specific. Generally, we found that some of the RNA molecules (HOTAIR and MALAT1) are down-regulated while many of them (lincRNA-p21, GAS5, MEG3, ANRIL, and ncRNA-CCND1) are up-regulated and some others (TUG1, UCA1, and PANDA) not affected. 469 HOTAIR http://lncrna.com/hotair/ lncRNA apoptosis Homo sapiens oesophageal squamous cell carcinoma 24022190 9606 The knockdown of HOTAIR in the KYSE510 and KYSE180 ESCC cell lines using small hairpin RNAs (shRNAs) reduced the ability of the cells to form foci, migrate, and invade the extracellular matrix in culture, altered cell cycle progression, and increased the sensitivity of the cells to apoptosis. 470 HOTAIR http://lncrna.com/hotair/ lncRNA apoptosis Homo sapiens gastric 25063030 9606 We found that HOTAIR was involved in inhibition of apoptosis and promoted invasiveness, supporting a role for HOTAIR in carcinogenesis and progression of gastric cancer. 471 HOXA-AS2 http://www.ncbi.nlm.nih.gov/gene/term=HOXA-AS2++human lncRNA apoptosis down Homo sapiens NB4cells 23649634 9606 8743 TL2|APO2L|CD253|TNFSF10|Apo-2L HGNC:11925|Ensembl:ENSG00000121858|HPRD:04670|MIM:603598|Vega:OTTHUMG00000156917 3 3q26 tumor necrosis factor (ligand) superfamily, member 10 protein coding tumor necrosis factor (ligand) superfamily, member 10 The increase in death of HOXA-AS2 knockdown cells was accompanied by an elevated TNF-related apoptosis-inducing ligand (TRAIL) levels, but ATRA-induced NB4 cells treated with TRAIL did show an increase in HOXA-AS2 expression. 472 htr2a-as1 http://www.genenames.org/data/hgnc_data.php?hgnc_id=40289 lncRNA PCNA apoptosis down Homo sapiens hepatocellular carcinoma cells 17932748 9606 5111 - HGNC:8729|MIM:176740|Ensembl:ENSG00000132646|HPRD:01456|Vega:OTTHUMG00000031798 20 20pter-p12 proliferating cell nuclear antigen protein-coding proliferating cell nuclear antigen DNA polymerase delta auxi HepG2 cells transfected with the antisense hTR gene showed down-regulated telomerase activity, inhibited cell growth, decreased PCNA expression, and increased apoptotic rate. 473 htr2a-as1 http://www.genenames.org/data/hgnc_data.php?hgnc_id=40289 lncRNA apoptosis Homo sapiens malignant glioma cells 17912434 9606 Apoptosis-inducing agents (CDDP and PTX) but not autophagy-inducing therapies (TMZ and IR) enhanced the incidence of apoptosis caused by 2-5A-anti-hTR. 474 HULC http://lncrna.com/HULC/ lncRNA apoptosis Homo sapiens gastric 24247585 9606 Mechanistically, we discovered that overexpression of HULC could induce patterns of autophagy in SGC7901 cells; more importantly, autophagy inhibition increased overexpression of HULC cell apoptosis. 475 INXS lncRNA BCL2L1 apoptosis Homo sapiens kidney tumor cell 24992962 9606 598 BCL-XL/S|BCL2L|BCLX|BCLXL|BCLXS|Bcl-X|PPP1R52|bcl-xL|bcl-xS HGNC:992|MIM:600039|Ensembl:ENSG00000171552|HPRD:02497|Vega:OTTHUMG00000032192 20 20q11.21 BCL2-like 1 protein-coding BCL2-like 1 Three apoptosis-inducing agents increased INXS lncRNA endogenous expression in the 786-O kidney tumor cell line, increased BCL-XS/BCL-XL mRNA ratio and activated caspases 3, 7 and 9. These effects were abrogated in the presence of INXS knockdown. Similarly, ectopic INXS overexpression caused a shift in splicing toward BCL-XS and activation of caspases, thus leading to apoptosis. 476 IPS1 http://lncrna.com/IPS1/ lncRNA apoptosis up ed Homo sapiens breast 25738636 9606 protein coding In the present study, we intended to determine the role of DAP3 in cancer cell behaviour in the context of human breast cancer. We developed knockdown sub-lines of MCF7 and MDA-MB-231.The expression of caspase-9 and IPS1, known components of the apoptosis pathway, were significantly reduced in the MCF7DAP3kd cells (p=0.05 and p=0.003, respectively). 477 Lin28b lncRNA BIRC5 apoptosis up Homo sapiens oral squamous cell 24386298 9606 332 API4|EPR-1 HGNC:593|MIM:603352|Ensembl:ENSG00000089685|HPRD:04520|Vega:OTTHUMG00000177505 17 17q25 baculoviral IAP repeat containing 5 protein-coding baculoviral IAP repeat containing 5 Besides, stable expressing Lin28B in oral cancer cells promoted cell migration, invasion, colony formation, in vivo proliferation and increased the expression of cancer suppressor miRNA let-7 targeted genes IL-6, HMGA2, the EMT markers Snail and Twist, the angiogenesis inducer VEGF, and the apoptosis inhibitor Survivin. These combined results indicate that Lin28B is a novel marker for predicting prognosis in patients with OSCC and may be a therapeutic target. 478 LINC00312 http://lncrna.com/linc00312/ lncRNA apoptosis Homo sapiens nasopharyngeal carcinoma 23529758 9606 The long intergenic non-coding RNA LINC00312, also called NAG7, was first cloned by our group. Our previous studies have found that LINC00312 could inhibit proliferation and induce apoptosis in nasopharynge 479 Linc00974 lncRNA KRT19 apoptosis Homo sapiens hepatocellular carcinoma cell 25476897 9606 3880 CK19|K19|K1CS HGNC:6436|MIM:148020|Ensembl:ENSG00000171345|HPRD:01007|Vega:OTTHUMG00000133422 17 17q21.2 keratin 19 protein-coding keratin 19 Knockdown of Linc00974 resulted in an inhibition of cell proliferation and invasion with an activation of apoptosis and cell cycle arrest in vitro, which was also validated by a subcutaneous and tail vein/intraperitoneal injection xenotransplantation model in vivo. We further investigated the interaction pattern of Linc00974 and KRT19. MiR-642 was identified, by acting as the competing endogenous RNA in regulating Linc00974 and KRT19. Linc00974 was increased owing to an abnormal hypomethylation promoter, which induced the upregulation of KRT19 via ceRNA interaction, resulting in the activation of the Notch and TGF-¦Â pathways as detected by cDNA microarray. 480 LincRNA-EPS http://lncrna.com/lincrna-eps/ lncRNA apoptosis Homo sapiens 22190456 9606 In this issue of Genes & Development, Hu and colleagues (2573-2578) report the discovery of LincRNA erythroid prosurvival (LincRNA-EPS), a murine lncRNA that facilitates red blood cell formation (erythropoiesis) by suppressing apoptosis. 481 lincRNA-p21 http://lncrna.com/lincRNA-p21/ lncRNA CTNNBIP1 apoptosis down Homo sapiens colorectal cancer cell 24573322 9606 56998 ICAT HGNC:16913|MIM:607758|Ensembl:ENSG00000178585|HPRD:09677|Vega:OTTHUMG00000001796 1 1p36.22 catenin, beta interacting protein 1 protein-coding catenin, beta interacting protein 1 By expression profile analysis, we demonstrated that lincRNA-p21 decreases in CRC cell lines and tissue samples, which contributes to the elevation of ¦Â-catenin in CRC. We further showed that lincRNA-p21 increases following X-ray treatment, and enforced expression of the lincRNA enhances the sensitivity of radiotherapy for CRC by promoting cell apoptosis. Suppression of the ¦Â-catenin signaling pathway and elevation of the pro-apoptosis gene Noxa expression may help explain the role of lincRNA-p21 in CRC radiotherapy. 482 lincRNA-p21 http://lncrna.com/lincRNA-p21/ lncRNA PMAIP1 apoptosis up Homo sapiens colorectal cancer cell 24573322 9606 5366 APR|NOXA HGNC:9108|MIM:604959|Ensembl:ENSG00000141682|HPRD:12002|Vega:OTTHUMG00000132765 18 18q21.32 phorbol-12-myristate-13-acetate-induced protein 1 protein-coding phorbol-12-myristate-13-acetate-induced protein 1 By expression profile analysis, we demonstrated that lincRNA-p21 decreases in CRC cell lines and tissue samples, which contributes to the elevation of ¦Â-catenin in CRC. We further showed that lincRNA-p21 increases following X-ray treatment, and enforced expression of the lincRNA enhances the sensitivity of radiotherapy for CRC by promoting cell apoptosis. Suppression of the ¦Â-catenin signaling pathway and elevation of the pro-apoptosis gene Noxa expression may help explain the role of lincRNA-p21 in CRC radiotherapy. 483 lincRNA-p21 http://lncrna.com/lincRNA-p21/ lncRNA apoptosis up Homo sapiens breast cancer cells 22487937 9606 Our results reveal that basal RNA expression levels as well as the changes in the lncRNA expression rates during genotoxic stress-induced apoptosis were cell-type and/or DNA-damaging agent-specific. Generally, we found that some of the RNA molecules (HOTAIR and MALAT1) are down-regulated while many of them (lincRNA-p21, GAS5, MEG3, ANRIL, and ncRNA-CCND1) are up-regulated and some others (TUG1, UCA1, and PANDA) not affected. 484 lincRNA-p21 http://lncrna.com/lincRNA-p21/ lncRNA apoptosis up Homo sapiens smooth muscle cell 25156994 9606 we showed that lincRNA-p21 represses cell proliferation and induces apoptosis in vascular smooth muscle cells and mouse mononuclear macrophage cells in vitro 485 lincRNA-RoR http://lncrna.com/lincRNA-RoR/ lncRNA TGFB1 apoptosis up Homo sapiens Hepatocellular cancers 24918061 9606 7040 CED|DPD1|LAP|TGFB|TGFbeta HGNC:11766|MIM:190180|HPRD:01821 19 19q13.1 transforming growth factor, beta 1 protein-coding transforming growth factor, beta 1 Incubation with HCC-derived extracellular vesicles increased linc-ROR expression and reduced chemotherapy-induced cell death in recipient cells.TGF¦Â selectively enriches linc-RoR within extracellular vesicles, which has a potential role in intercellular signaling in response to TGF¦Â; 486 lincRNA-RoR http://lncrna.com/lincRNA-RoR/ lncRNA TP53 apoptosis down Homo sapiens 23208419 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 antigen NY-CO-13; cellula The human long non-coding RNA-RoR is a p53 repressor in response to DNA damage.RoR inhibits p53-mediated cell cycle arrest and apoptosis. 487 lincRNA-UFC1 lncRNA CTNNB1 apoptosis down Homo sapiens hepatocellular carcinoma cell 25449213 9606 1499 CTNNB|MRD19|armadillo HGNC:2514|MIM:116806|Ensembl:ENSG00000168036|HPRD:00286|Vega:OTTHUMG00000131393 3 3p21 catenin (cadherin-associated protein), beta 1, 88kDa protein-coding catenin (cadherin-associated protein), beta 1, 88kDa Transgenic expression of the lincRNA-UFC1 in HCC cells promoted their proliferation and cell-cycle progression and inhibited apoptosis, whereas short hairpin RNA knockdown of lincRNA-UFC1 had opposite effects. Tumors grown from lincRNA-UFC1 knockdown were smaller than controls. The lincRNA-UFC1 interacted directly with the messenger RNA (mRNA) stabilizing protein HuR (encoded by ELAVL1) to increase levels of ¦Â-catenin mRNA (encoded by CTNNB1) and protein. Levels of lincRNA-UFC1 correlated with those of ¦Â-catenin in HCC tissues.In contrast, there was a negative correlation between levels of microRNA 34a and lincRNA-UFC1 in HCC tissues; microRNA 34a reduced the stability of lincRNA-UFC1. 488 lincRNA-UFC1 lncRNA ELAVL1 apoptosis Homo sapiens hepatocellular carcinoma cell 25449213 9606 1994 ELAV1|HUR|Hua|MelG HGNC:3312|MIM:603466|Ensembl:ENSG00000066044|HPRD:16025|Vega:OTTHUMG00000182470 19 19p13.2 ELAV like RNA binding protein 1 protein-coding ELAV like RNA binding protein 1 Transgenic expression of the lincRNA-UFC1 in HCC cells promoted their proliferation and cell-cycle progression and inhibited apoptosis, whereas short hairpin RNA knockdown of lincRNA-UFC1 had opposite effects. Tumors grown from lincRNA-UFC1 knockdown were smaller than controls. The lincRNA-UFC1 interacted directly with the messenger RNA (mRNA) stabilizing protein HuR (encoded by ELAVL1) to increase levels of ¦Â-catenin mRNA (encoded by CTNNB1) and protein. Levels of lincRNA-UFC1 correlated with those of ¦Â-catenin in HCC tissues.In contrast, there was a negative correlation between levels of microRNA 34a and lincRNA-UFC1 in HCC tissues; microRNA 34a reduced the stability of lincRNA-UFC1. 489 lncRNA-BGL3 http://lncrna.com/lncrna-bgl3/ lncRNA ABL1 apoptosis down Homo sapiens myeloid leukemia 24837367 9606 25 ABL|JTK7|bcr/abl|c-ABL|c-ABL1|p150|v-abl HGNC:76|MIM:189980|Ensembl:ENSG00000097007|HPRD:01809|Vega:OTTHUMG00000020813 9 9q34.1 ABL proto-oncogene 1, non-receptor tyrosine kinase protein-coding ABL proto-oncogene 1, non-receptor tyrosine kinase Ectopic expression of lncRNA-BGL3 sensitized leukemic cells to undergo apoptosis and inhibited Bcr-Abl-induced tumorigenesis. 490 lncRNA-BGL3 http://lncrna.com/lncrna-bgl3/ lncRNA BCR apoptosis down Homo sapiens myeloid leukemia 24837367 9606 613 ALL|BCR1|CML|D22S11|D22S662|PHL HGNC:1014|MIM:151410|Ensembl:ENSG00000186716|HPRD:01044|Vega:OTTHUMG00000150655 22 22q11.23 breakpoint cluster region protein-coding breakpoint cluster region Ectopic expression of lncRNA-BGL3 sensitized leukemic cells to undergo apoptosis and inhibited Bcr-Abl-induced tumorigenesis. 491 lncRNA-LET http://lncrna.com/lncrna-let/ lncRNA apoptosis Homo sapiens 25213660 9606 The ectopic expression of lncRNA-LET led to the promotion of cell cycle arrest at G0/G1 phase and to the induction of apoptosis under hypoxic conditions. 492 lncRNA-p21 http://lncrna.com/lincRNA-p21/ lncRNA apoptosis up Homo sapiens HeLa and caspase-3-deficient MCF-7 cell 22487937 9606 Our results reveal that basal RNA expression levels as well as the changes in the lncRNA expression rates during genotoxic stress-induced apoptosis were cell-type and/or DNA-damaging agent-specific. Generally, we found that some of the RNA molecules (HOTAIR and MALAT1) are down-regulated while many of them (lincRNA-p21, GAS5, MEG3, ANRIL, and ncRNA-CCND1) are up-regulated and some others (TUG1, UCA1, and PANDA) not affected. 493 Loc554202 lncRNA apoptosis Homo sapiens breast cancer cell 24631686 9606 Moreover, knockdown of Loc554202 decreased breast cancer cell proliferation, induced apoptosis and inhibits migration/invasion in vitro and impeded tumorigenesis in vivo. These data suggest an important role of Loc554202 in breast tumorigenesis. 494 lust http://www.lncrnadb.org/Detail.aspx?TKeyID=146 lncRNA RBM5 apoptosis Homo sapiens 19559772 9606 10181 G15|LUCA15|RMB5 HGNC:9902|MIM:606884|Ensembl:ENSG00000003756|HPRD:06052|Vega:OTTHUMG00000156785 3 3p21.3 RNA binding motif protein 5 protein-coding RNA binding motif protein 5 RNA-binding protein 5; pu LUST is a novel, functional, non-coding RNA that plays a role in determining the apoptotic fate of a cell by regulating the expression of RBM5 splice variants. 495 MALAT1 http://www.lncrnadb.org/Malat1/ lncRNA BAX apoptosis up Homo sapiens cervical cancer cells 20937273 9606 581 BCL2L4 HGNC:959|MIM:600040|Ensembl:ENSG00000087088|HPRD:02498|Vega:OTTHUMG00000160476 19 19q13.3-q13.4 BCL2-associated X protein protein-coding BCL2-associated X protein BCL2-associated X protein MALAT1 supports proliferation and invasion of cervical cancer cells and knockdown of MALAT1 in CaSki cells led to an upregulation of caspase-8 and -3 and Bax and the downregulation of Bcl-2 and Bcl-xL.Thus, both studies find a plethora of potential MALAT1 functions linked to proliferation, apoptosis, migration or gene regulation and future studies will have to unravel the specificity of these effects. 496 MALAT1 http://www.lncrnadb.org/Malat1/ lncRNA BCL2 apoptosis down Homo sapiens cervical cancer cells 20937273 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 apoptosis regulator Bcl-2 MALAT1 supports proliferation and invasion of cervical cancer cells and knockdown of MALAT1 in CaSki cells led to an upregulation of caspase-8 and -3 and Bax and the downregulation of Bcl-2 and Bcl-xL.Thus, both studies find a plethora of potential MALAT1 functions linked to proliferation, apoptosis, migration or gene regulation and future studies will have to unravel the specificity of these effects. 497 MALAT1 http://www.lncrnadb.org/Malat1/ lncRNA BCL2 apoptosis Homo sapiens non-small-cell lung cancer cell 25036876 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Bcl-2 expression was specifically associated with superior prognosis in localized NSCLC. An interaction of Bcl-2 with MALAT-1 lncRNA expression was revealed, which merits further investigation for risk prediction in resectable NSCLC patients 498 MALAT1 http://www.lncrnadb.org/Malat1/ lncRNA BCL2L1 apoptosis down Homo sapiens cervical cancer cells 20937273 9606 598 BCL-XL/S|BCL2L|BCLX|BCLXL|BCLXS|Bcl-X|PPP1R52|bcl-xL|bcl-xS HGNC:992|MIM:600039|Ensembl:ENSG00000171552|HPRD:02497|Vega:OTTHUMG00000032192 20 20q11.21 BCL2-like 1 protein-coding BCL2-like 1 apoptosis regulator Bcl-X MALAT1 supports proliferation and invasion of cervical cancer cells and knockdown of MALAT1 in CaSki cells led to an upregulation of caspase-8 and -3 and Bax and the downregulation of Bcl-2 and Bcl-xL.Thus, both studies find a plethora of potential MALAT1 functions linked to proliferation, apoptosis, migration or gene regulation and future studies will have to unravel the specificity of these effects. 499 MALAT1 http://www.lncrnadb.org/Malat1/ lncRNA CASP3 apoptosis up Homo sapiens cervical cancer cells 20937273 9606 836 CPP32|CPP32B|SCA-1 HGNC:1504|MIM:600636|Ensembl:ENSG00000164305|HPRD:02799|Vega:OTTHUMG00000133681 4 4q34 caspase 3, apoptosis-related cysteine peptidase protein-coding caspase 3, apoptosis-related cysteine peptidase CASP-3|CPP-32|PARP cleava MALAT1 supports proliferation and invasion of cervical cancer cells and knockdown of MALAT1 in CaSki cells led to an upregulation of caspase-8 and -3 and Bax and the downregulation of Bcl-2 and Bcl-xL.Thus, both studies find a plethora of potential MALAT1 functions linked to proliferation, apoptosis, migration or gene regulation and future studies will have to unravel the specificity of these effects. 500 MALAT1 http://www.lncrnadb.org/Malat1/ lncRNA CASP8 apoptosis up Homo sapiens cervical cancer cells 20937273 9606 841 ALPS2B|CAP4|Casp-8|FLICE|MACH|MCH5 HGNC:1509|MIM:601763|Ensembl:ENSG00000064012|HPRD:03459|Vega:OTTHUMG00000132821 2 2q33-q34 caspase 8, apoptosis-related cysteine peptidase protein-coding caspase 8, apoptosis-related cysteine peptidase FADD-homologous ICE/CED-3 MALAT1 supports proliferation and invasion of cervical cancer cells and knockdown of MALAT1 in CaSki cells led to an upregulation of caspase-8 and -3 and Bax and the downregulation of Bcl-2 and Bcl-xL.Thus, both studies find a plethora of potential MALAT1 functions linked to proliferation, apoptosis, migration or gene regulation and future studies will have to unravel the specificity of these effects. 501 MALAT1 http://www.lncrnadb.org/Malat1/ lncRNA CDH1 apoptosis up Homo sapiens renal cell carcinoma 25600645 9606 999 Arc-1|CD324|CDHE|ECAD|LCAM|UVO HGNC:1748|MIM:192090|Ensembl:ENSG00000039068|HPRD:01885|Vega:OTTHUMG00000137561 16 16q22.1 cadherin 1, type 1, E-cadherin (epithelial) protein-coding cadherin 1, type 1, E-cadherin (epithelial) Mechanistic investigations showed that MALAT1 was transcriptionally activated by c-Fos and that it interacted with Ezh2. After MALAT1 silencing, E-cadherin expression was increased, whereas ¦Â-catenin expression was decreased through Ezh2. Reciprocal interaction between MALAT1 and miR-205 was also observed. 502 MALAT1 http://www.lncrnadb.org/Malat1/ lncRNA CTNNB1 apoptosis down Homo sapiens renal cell carcinoma 25600645 9606 1499 CTNNB|MRD19|armadillo HGNC:2514|MIM:116806|Ensembl:ENSG00000168036|HPRD:00286|Vega:OTTHUMG00000131393 3 3p21 catenin (cadherin-associated protein), beta 1, 88kDa protein-coding catenin (cadherin-associated protein), beta 1, 88kDa Mechanistic investigations showed that MALAT1 was transcriptionally activated by c-Fos and that it interacted with Ezh2. After MALAT1 silencing, E-cadherin expression was increased, whereas ¦Â-catenin expression was decreased through Ezh2. Reciprocal interaction between MALAT1 and miR-205 was also observed. 503 MALAT1 http://www.lncrnadb.org/Malat1/ lncRNA EZH2 apoptosis Homo sapiens renal cell carcinoma 25600645 9606 2146 ENX-1|ENX1|EZH1|EZH2b|KMT6|KMT6A|WVS|WVS2 HGNC:3527|MIM:601573|Ensembl:ENSG00000106462|HPRD:03342|Vega:OTTHUMG00000158973 7 7q35-q36 enhancer of zeste 2 polycomb repressive complex 2 subunit protein-coding enhancer of zeste 2 polycomb repressive complex 2 subunit Mechanistic investigations showed that MALAT1 was transcriptionally activated by c-Fos and that it interacted with Ezh2. After MALAT1 silencing, E-cadherin expression was increased, whereas ¦Â-catenin expression was decreased through Ezh2. Reciprocal interaction between MALAT1 and miR-205 was also observed. 504 MALAT1 http://www.lncrnadb.org/Malat1/ lncRNA FOS apoptosis Homo sapiens renal cell carcinoma 25600645 9606 2353 AP-1|C-FOS|p55 HGNC:3796|MIM:164810|Ensembl:ENSG00000170345|HPRD:01275|Vega:OTTHUMG00000171774 14 14q24.3 FBJ murine osteosarcoma viral oncogene homolog protein-coding FBJ murine osteosarcoma viral oncogene homolog Mechanistic investigations showed that MALAT1 was transcriptionally activated by c-Fos and that it interacted with Ezh2. After MALAT1 silencing, E-cadherin expression was increased, whereas ¦Â-catenin expression was decreased through Ezh2. Reciprocal interaction between MALAT1 and miR-205 was also observed. 505 MALAT1 http://www.lncrnadb.org/Malat1/ lncRNA PCDH10 apoptosis down Homo sapiens endometrioid endometrial carcinoma 25085246 9606 57575 OL-PCDH|PCDH19 HGNC:13404|MIM:608286|HPRD:12204 4 4q28.3 protocadherin 10 protein-coding protocadherin 10 Restoring PCDH10 levels suppressed cell growth and triggered apoptosis in EEC cells and tumor xenografts.We found that MALAT1 transcription was regulated by Wnt/¦Â-catenin signaling via TCF promoter binding and PCDH10 decreased MALAT1 by modulating this pathway. 506 MALAT1 http://www.lncrnadb.org/Malat1/ lncRNA PTBP2 apoptosis Homo sapiens osteosarcoma cell 25592968 9606 58155 PTBLP|brPTB|nPTB HGNC:17662|MIM:608449|Ensembl:ENSG00000117569|HPRD:12233|Vega:OTTHUMG00000010685 1 1p21.3 polypyrimidine tract binding protein 2 protein-coding polypyrimidine tract binding protein 2 Consistent with a previous study, high dose of E2 treatment dramatically downregulated expressing level of long non-coding RNA metastasis associated lung adenocarcinoma transcript 1 (MALAT-1). Downregulation of MALAT-1 promoted the combination of SFPQ/PTBP2 complex. It was also observed that the proliferation, migration, invasion, colony formation and apoptosis of OS cells were remarkably affected by high dose of E2 treatment, but not by low dose, in an ER¦Á independent manner. 507 MALAT1 http://www.lncrnadb.org/Malat1/ lncRNA SFPQ apoptosis Homo sapiens osteosarcoma cell 25592968 9606 654780 - - 16 16q24.1 splicing factor proline/glutamine-rich ncRNA - Consistent with a previous study, high dose of E2 treatment dramatically downregulated expressing level of long non-coding RNA metastasis associated lung adenocarcinoma transcript 1 (MALAT-1). Downregulation of MALAT-1 promoted the combination of SFPQ/PTBP2 complex. It was also observed that the proliferation, migration, invasion, colony formation and apoptosis of OS cells were remarkably affected by high dose of E2 treatment, but not by low dose, in an ER¦Á independent manner. 508 MALAT1 http://www.lncrnadb.org/Malat1/ lncRNA apoptosis Homo sapiens hepatocellular carcinoma cells 21678027 9606 Inhibition of MALAT1 in HepG2 cells could effectively reduce cell viability, motility, invasiveness, and increase the sensitivity to apoptosis. 509 MALAT1 http://www.lncrnadb.org/Malat1/ lncRNA apoptosis down Homo sapiens breast cancer cells 22487937 9606 Our results reveal that basal RNA expression levels as well as the changes in the lncRNA expression rates during genotoxic stress-induced apoptosis were cell-type and/or DNA-damaging agent-specific. Generally, we found that some of the RNA molecules (HOTAIR and MALAT1) are down-regulated while many of them (lincRNA-p21, GAS5, MEG3, ANRIL, and ncRNA-CCND1) are up-regulated and some others (TUG1, UCA1, and PANDA) not affected. 510 MALAT1 http://www.lncrnadb.org/Malat1/ lncRNA apoptosis down Homo sapiens laryngeal squamous cell carcinoma cells 23104528 9606 The apoptosis cells were increased in MALAT-1 siRNA lentivirus-treated LSCC xenografts than the control. 511 MALAT1 http://www.lncrnadb.org/Malat1/ lncRNA apoptosis Homo sapiens bladder 23153939 9606 Cell proliferation inhibition, increased apoptosis, and decreased motility were observed in MALAT1 small interfering RNA-transfected bladder urothelial carcinoma T24 and 5637 cells. 512 MALAT1 http://www.lncrnadb.org/Malat1/ lncRNA apoptosis Homo sapiens pancreatic cancer 25269958 9606 Consistently, higher expression level of MALAT-1 was found in all seven pancreatic cancer cell lines relative to the human pancreatic ductal epithelial cell. Further function analysis revealed that downregulation of MALAT-1 could inhibit tumor cell proliferation and decrease cell migration and invasion in vitro. The underlying mechanisms are possibly involved in inducing G2/M cell cycle arrest, promoting cell apoptosis, suppressing epithelial-mesenchymal transition and reducing cancer stem-like properties. In conclusion, this study indicated that MALAT-1 may serve as an oncogenic lncRNA that is involved in malignancy phenotypes of pancreatic cancer. Therefore, it may be used as a potential therapeutic target. 513 mdm2-as http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=6973 lncRNA AR apoptosis down Homo sapiens prostate cancer cells 19010821 9606 367 AIS|DHTR|HUMARA|HYSP1|KD|NR3C4|SBMA|SMAX1|TFM HGNC:644|MIM:313700|Ensembl:ENSG00000169083|HPRD:02437|Vega:OTTHUMG00000021740 X Xq12 androgen receptor protein-coding androgen receptor androgen nuclear receptor In this study, the effect of Ad-E2F1 and AS-MDM2 in combination with radiation was investigated in three prostate cancer cell lines: LNCaP cells, LNCaP-Res cells [androgen insensitive with functional p53 and androgen receptor (AR)], and PC3 cells (androgen insensitive, p53(null), and AR(null)). A supra-additive radiosensitizing effect was observed in terms of clonogenic inhibition and induction of apoptosis (caspase-3 + caspase-7 activity) in response to Ad-E2F1 plus AS-MDM2 treatments in all three cell lines. In LNCaP and LNCaP-Res, these combination treatments elevated the levels of phospho-Ser(15) p53 with significant induction of p21(waf1/cip1), phospho-gammaH2AX, PUMA, and Bax levels and reduction of AR and bcl-2 expression. 514 mdm2-as http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=6973 lncRNA BAX apoptosis up Homo sapiens prostate cancer cells 19010821 9606 581 BCL2L4 HGNC:959|MIM:600040|Ensembl:ENSG00000087088|HPRD:02498|Vega:OTTHUMG00000160476 19 19q13.3-q13.4 BCL2-associated X protein protein-coding BCL2-associated X protein BCL2-associated X protein In this study, the effect of Ad-E2F1 and AS-MDM2 in combination with radiation was investigated in three prostate cancer cell lines: LNCaP cells, LNCaP-Res cells [androgen insensitive with functional p53 and androgen receptor (AR)], and PC3 cells (androgen insensitive, p53(null), and AR(null)). A supra-additive radiosensitizing effect was observed in terms of clonogenic inhibition and induction of apoptosis (caspase-3 + caspase-7 activity) in response to Ad-E2F1 plus AS-MDM2 treatments in all three cell lines. In LNCaP and LNCaP-Res, these combination treatments elevated the levels of phospho-Ser(15) p53 with significant induction of p21(waf1/cip1), phospho-gammaH2AX, PUMA, and Bax levels and reduction of AR and bcl-2 expression. 515 mdm2-as http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=6973 lncRNA BBC3 apoptosis up Homo sapiens prostate cancer cells 19010821 9606 27113 JFY-1|JFY1|PUMA HGNC:17868|MIM:605854|Ensembl:ENSG00000105327|HPRD:16165|Vega:OTTHUMG00000183489 19 19q13.3-q13.4 BCL2 binding component 3 protein-coding BCL2 binding component 3 bcl-2-binding component 3 In this study, the effect of Ad-E2F1 and AS-MDM2 in combination with radiation was investigated in three prostate cancer cell lines: LNCaP cells, LNCaP-Res cells [androgen insensitive with functional p53 and androgen receptor (AR)], and PC3 cells (androgen insensitive, p53(null), and AR(null)). A supra-additive radiosensitizing effect was observed in terms of clonogenic inhibition and induction of apoptosis (caspase-3 + caspase-7 activity) in response to Ad-E2F1 plus AS-MDM2 treatments in all three cell lines. In LNCaP and LNCaP-Res, these combination treatments elevated the levels of phospho-Ser(15) p53 with significant induction of p21(waf1/cip1), phospho-gammaH2AX, PUMA, and Bax levels and reduction of AR and bcl-2 expression. 516 mdm2-as http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=6973 lncRNA BCL2 apoptosis down Homo sapiens prostate cancer cells 19010821 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 apoptosis regulator Bcl-2 In this study, the effect of Ad-E2F1 and AS-MDM2 in combination with radiation was investigated in three prostate cancer cell lines: LNCaP cells, LNCaP-Res cells [androgen insensitive with functional p53 and androgen receptor (AR)], and PC3 cells (androgen insensitive, p53(null), and AR(null)). A supra-additive radiosensitizing effect was observed in terms of clonogenic inhibition and induction of apoptosis (caspase-3 + caspase-7 activity) in response to Ad-E2F1 plus AS-MDM2 treatments in all three cell lines. In LNCaP and LNCaP-Res, these combination treatments elevated the levels of phospho-Ser(15) p53 with significant induction of p21(waf1/cip1), phospho-gammaH2AX, PUMA, and Bax levels and reduction of AR and bcl-2 expression. 517 mdm2-as http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=6973 lncRNA CDKN1A apoptosis up Homo sapiens prostate cancer cells 19010821 9606 1026 CAP20|CDKN1|CIP1|MDA-6|P21|SDI1|WAF1|p21CIP1 HGNC:1784|MIM:116899|Ensembl:ENSG00000124762|HPRD:00298|Vega:OTTHUMG00000014603 6 6p21.2 cyclin-dependent kinase inhibitor 1A (p21, Cip1) protein-coding cyclin-dependent kinase inhibitor 1A (p21, Cip1) CDK-interacting protein 1 In this study, the effect of Ad-E2F1 and AS-MDM2 in combination with radiation was investigated in three prostate cancer cell lines: LNCaP cells, LNCaP-Res cells [androgen insensitive with functional p53 and androgen receptor (AR)], and PC3 cells (androgen insensitive, p53(null), and AR(null)). A supra-additive radiosensitizing effect was observed in terms of clonogenic inhibition and induction of apoptosis (caspase-3 + caspase-7 activity) in response to Ad-E2F1 plus AS-MDM2 treatments in all three cell lines. In LNCaP and LNCaP-Res, these combination treatments elevated the levels of phospho-Ser(15) p53 with significant induction of p21(waf1/cip1), phospho-gammaH2AX, PUMA, and Bax levels and reduction of AR and bcl-2 expression. 518 MEG3 http://lncrna.com/MEG3/ lncRNA BAX apoptosis Homo sapiens HTR-8/SVneo and JEG4 cells 25358633 9606 581 BCL2L4 HGNC:959|MIM:600040|Ensembl:ENSG00000087088|HPRD:02498|Vega:OTTHUMG00000160476 19 19q13.3-q13.4 BCL2-associated X protein protein-coding BCL2-associated X protein Over-expression of MEG3 reduced apoptosis and promoted migration of HTR-8/SVneo and JEG3 cells. Furthermore, inhibition of endogenous MEG3 increased apoptosis and decreased migration of HTR-8/SVneo and JEG3 cells. Additionally, lncRNA MEG3 influenced expression of NF-¦ÊB, Caspase-3, and Bax protein expressions in trophoblast cells. 519 MEG3 http://lncrna.com/MEG3/ lncRNA CASP3 apoptosis Homo sapiens HTR-8/SVneo and JEG3 cells 25358633 9606 836 CPP32|CPP32B|SCA-1 HGNC:1504|MIM:600636|Ensembl:ENSG00000164305|HPRD:02799|Vega:OTTHUMG00000133681 4 4q34 caspase 3, apoptosis-related cysteine peptidase protein-coding caspase 3, apoptosis-related cysteine peptidase Over-expression of MEG3 reduced apoptosis and promoted migration of HTR-8/SVneo and JEG3 cells. Furthermore, inhibition of endogenous MEG3 increased apoptosis and decreased migration of HTR-8/SVneo and JEG3 cells. Additionally, lncRNA MEG3 influenced expression of NF-¦ÊB, Caspase-3, and Bax protein expressions in trophoblast cells. 520 MEG3 http://lncrna.com/MEG3/ lncRNA MDM2 apoptosis Homo sapiens lung 24098911 9606 4193 ACTFS|HDMX|hdm2 HGNC:6973|MIM:164785|Ensembl:ENSG00000135679|HPRD:01272|Vega:OTTHUMG00000142827 12 12q14.3-q15 MDM2 proto-oncogene, E3 ubiquitin protein ligase protein-coding MDM2 proto-oncogene, E3 ubiquitin protein ligase Overexpression of MEG3 decreased NSCLC cells proliferation and induced apoptosis in vitro and impeded tumorigenesis in vivo. MDM2 and p53 protein levels were affected by MEG3 over-expression in vitro. 521 MEG3 http://lncrna.com/MEG3/ lncRNA TAB1 apoptosis Homo sapiens hepatic stellate 25201080 9606 10454 3'-Tab1|MAP3K7IP1 HGNC:18157|MIM:602615|Ensembl:ENSG00000100324|HPRD:04012|Vega:OTTHUMG00000151102 22 22q13.1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 protein-coding TGF-beta activated kinase 1/MAP3K7 binding protein 1 Expression of MEG3 was downregulated in human hepatic stellate cell lines LX-2 cells in response to transforming growth factor-¦Â1 (TGF-¦Â1) stimulation in dose and time-dependent manner. Enforced expression of MEG3 in LX-2 cells inhibited TGF-¦Â1-induced cell proliferation, while promoting cell apoptosis. 522 MEG3 http://lncrna.com/MEG3/ lncRNA TP53 apoptosis up Homo sapiens glioma cells 22234798 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 antigen NY-CO-13; cellula Ectopic expression of MEG3 inhibited cell proliferation and promoted cell apoptosis in U251 and U87 MG human glioma cell lines. 523 MEG3 http://lncrna.com/MEG3/ lncRNA TP53 apoptosis up Homo sapiens breast cancer cells 22393162 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 antigen NY-CO-13; cellula Re-expression of MEG3 inhibits tumor cell proliferation in culture and colony formation in soft agar.This growth inhibition is partly the result of apoptosis induced by meg3. 524 MEG3 http://lncrna.com/MEG3/ lncRNA TP53 apoptosis Homo sapiens gastric 24006224 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 Furthermore, knockdown of MEG3 expression by siRNA could promote cell proliferation, while ectopic expression of MEG3 inhibited cell proliferation, promoted cell apoptosis, and modulated p53 expression in gastric cancer cell lines. 525 MEG3 http://lncrna.com/MEG3/ lncRNA TP53 apoptosis Homo sapiens lung 24098911 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 Overexpression of MEG3 decreased NSCLC cells proliferation and induced apoptosis in vitro and impeded tumorigenesis in vivo. MDM2 and p53 protein levels were affected by MEG3 over-expression in vitro. 526 MEG3 http://lncrna.com/MEG3/ lncRNA TP53 apoptosis up Homo sapiens ovarian 24859196 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 In addition, ectopic expression of MEG3 suppressed the proliferation and growth of OVCAR3 cells and promoted apoptosis. Finally, MEG3 activated p53 in OVCAR3 cells. 527 MEG3 http://lncrna.com/MEG3/ lncRNA TP53 apoptosis up Homo sapiens 25201080 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 More importantly, overexpression of MEG3 could activate p53 and mediate cytochrome crelease, subsequently leading to caspase-3-dependent apoptosis in TGF-¦Â1-treated LX-2 cells. 528 MEG3 http://lncrna.com/MEG3/ lncRNA TP53 apoptosis up Homo sapiens hepatocellular carcinoma 25641194 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 The inhibition affection in proliferation and inducing affection in apoptosis was further confirmed in vivo and vitro, we also demonstrated that MEG3 regulates HCC cell proliferation and apoptosis partially via the accumulation of p53. Besides, the hypermethylation of MEG3 in promoter region was identified by bisulfite sequencing while MEG3 increased with the inhibition of methylation. Subsequently, UHRF1, a new identified oncogene which is required for DNA methylation and recruits, was investigated. A negative correlation of MEG3 and UHRF1 expression was verified in primary HCC tissues. Down-regulation of UHRF1 induced MEG3 expression in HCC cell lines, which could be reversed by the up-regulation of UHRF1. 529 MEG3 http://lncrna.com/MEG3/ lncRNA UHRF1 apoptosis Homo sapiens hepatocellular carcinoma 25641194 9606 29128 ICBP90|Np95|RNF106|hNP95|hUHRF1|huNp95 HGNC:12556|MIM:607990|HPRD:06992 19 19p13.3 ubiquitin-like with PHD and ring finger domains 1 protein-coding ubiquitin-like with PHD and ring finger domains 1 The inhibition affection in proliferation and inducing affection in apoptosis was further confirmed in vivo and vitro, we also demonstrated that MEG3 regulates HCC cell proliferation and apoptosis partially via the accumulation of p53. Besides, the hypermethylation of MEG3 in promoter region was identified by bisulfite sequencing while MEG3 increased with the inhibition of methylation. Subsequently, UHRF1, a new identified oncogene which is required for DNA methylation and recruits, was investigated. A negative correlation of MEG3 and UHRF1 expression was verified in primary HCC tissues. Down-regulation of UHRF1 induced MEG3 expression in HCC cell lines, which could be reversed by the up-regulation of UHRF1. 530 MEG3 http://lncrna.com/MEG3/ lncRNA apoptosis Homo sapiens hepatocellular cancer cells 21625215 9606 Enforced expression of MEG3 in HCC cells significantly decreased both anchorage-dependent and -independent cell growth, and induced apoptosis. 531 MEG3 http://lncrna.com/MEG3/ lncRNA apoptosis up Homo sapiens breast cancer cells 22487937 9606 Our results reveal that basal RNA expression levels as well as the changes in the lncRNA expression rates during genotoxic stress-induced apoptosis were cell-type and/or DNA-damaging agent-specific. Generally, we found that some of the RNA molecules (HOTAIR and MALAT1) are down-regulated while many of them (lincRNA-p21, GAS5, MEG3, ANRIL, and ncRNA-CCND1) are up-regulated and some others (TUG1, UCA1, and PANDA) not affected. 532 MEG3 http://lncrna.com/MEG3/ lncRNA apoptosis up Homo sapiens bladder cancer cells 23295831 9606 A significant negative correlation was observed between MEG3 levels and LC3-II (autophagy marker) levels in vivo. We further demonstrated that MEG3 markedly suppressed autophagy activation, whereas MEG3 knockdown activated autophagy in human bladder cancer cell lines. 533 MEG3 http://lncrna.com/MEG3/ lncRNA apoptosis Homo sapiens cervical carcinoma 23790166 9606 Further investigation into the mechanisms responsible for the growth inhibitory effects revealed that overexpression of MEG3 resulted in the induction of G2/M cell cycle arrest and apoptosis. 534 miR-642 hsa-miR-642a-5p,hsa-miR-642b-3p,hsa-miR-642a-3p,hsa-miR-642b-5p MIMAT0003312,MIMAT0018444,MIMAT0020924,MIMAT0022736 lncRNA KRT19 apoptosis down Homo sapiens hepatocellular carcinoma cell 25476897 9606 3880 CK19|K19|K1CS HGNC:6436|MIM:148020|Ensembl:ENSG00000171345|HPRD:01007|Vega:OTTHUMG00000133422 17 17q21.2 keratin 19 protein-coding keratin 19 Knockdown of Linc00974 resulted in an inhibition of cell proliferation and invasion with an activation of apoptosis and cell cycle arrest in vitro, which was also validated by a subcutaneous and tail vein/intraperitoneal injection xenotransplantation model in vivo. We further investigated the interaction pattern of Linc00974 and KRT19. MiR-642 was identified, by acting as the competing endogenous RNA in regulating Linc00974 and KRT19. Linc00974 was increased owing to an abnormal hypomethylation promoter, which induced the upregulation of KRT19 via ceRNA interaction, resulting in the activation of the Notch and TGF-¦Â pathways as detected by cDNA microarray. 535 miR-642 hsa-miR-642a-5p,hsa-miR-642b-3p,hsa-miR-642a-3p,hsa-miR-642b-5p MIMAT0003312,MIMAT0018444,MIMAT0020924,MIMAT0022736 lncRNA LINC00974 apoptosis Homo sapiens hepatocellular carcinoma cell 25476897 9606 147093 - HGNC:27105|Ensembl:ENSG00000226629 17 17q21.31 long intergenic non-protein coding RNA 974 ncRNA long intergenic non-protein coding RNA 974 Knockdown of Linc00974 resulted in an inhibition of cell proliferation and invasion with an activation of apoptosis and cell cycle arrest in vitro, which was also validated by a subcutaneous and tail vein/intraperitoneal injection xenotransplantation model in vivo. We further investigated the interaction pattern of Linc00974 and KRT19. MiR-642 was identified, by acting as the competing endogenous RNA in regulating Linc00974 and KRT19. Linc00974 was increased owing to an abnormal hypomethylation promoter, which induced the upregulation of KRT19 via ceRNA interaction, resulting in the activation of the Notch and TGF-¦Â pathways as detected by cDNA microarray. 536 MRUL lncRNA ABCB1 apoptosis Homo sapiens gastric cancer cell 24958102 9606 5243 ABC20|CD243|CLCS|GP170|MDR1|P-GP|PGY1 HGNC:40|MIM:171050|Ensembl:ENSG00000085563|HPRD:01370|Vega:OTTHUMG00000023393 7 7q21.12 ATP-binding cassette, sub-family B (MDR/TAP), member 1 protein-coding ATP-binding cassette, sub-family B (MDR/TAP), member 1 We show here that the lncRNA MRUL (MDR-related and upregulated lncRNA), located 400 kb downstream of ABCB1 (ATP-binding cassette, subfamily B, member 1), was significantly upregulated in two multidrug-resistant GC cell sublines, SGC7901/ADR and SGC7901/VCR. MRUL knockdown in SGC7901/ADR and SGC7901/VCR cells led to increased rates of apoptosis, increased accumulation, and reduced doxorubicin (Adriamycin [ADR]) release in the presence of ADR or vincristine. Moreover, MRUL depletion reduced ABCB1 mRNA levels in a dose- and time-dependent manner. Heterologous luciferase reporter assays demonstrated that MRUL might positively affect ABCB1 expression in an orientation- and position-independent manner. 537 ncRNA-CCND1 http://www.lncrnadb.org/p53mrna/ lncRNA apoptosis up Homo sapiens HeLa and caspase-3-deficient MCF-7 cell 22487937 9606 Our results reveal that basal RNA expression levels as well as the changes in the lncRNA expression rates during genotoxic stress-induced apoptosis were cell-type and/or DNA-damaging agent-specific. Generally, we found that some of the RNA molecules (HOTAIR and MALAT1) are down-regulated while many of them (lincRNA-p21, GAS5, MEG3, ANRIL, and ncRNA-CCND1) are up-regulated and some others (TUG1, UCA1, and PANDA) not affected. 538 NEAT1 lncRNA EPAS1 apoptosis down Homo sapiens breast 25417700 9606 2034 ECYT4|HIF2A|HLF|MOP2|PASD2|bHLHe73 HGNC:3374|MIM:603349|Ensembl:ENSG00000116016|HPRD:06787|Vega:OTTHUMG00000128818 2 2p21-p16 endothelial PAS domain protein 1 protein-coding endothelial PAS domain protein 1 Here, we show that NEAT1 long non-coding RNA (lncRNA) is a direct transcriptional target of HIF in many breast cancer cell lines and in solid tumors. Unlike previously described lncRNAs, NEAT1 is regulated principally by HIF-2 rather than by HIF-1. Induction of NEAT1 in hypoxia also leads to accelerated cellular proliferation, improved clonogenic survival and reduced apoptosis, all of which are hallmarks of increased tumorigenesis. 539 Ntab http://www.valadkhanlab.org/web/cgi-bin/output_1.cgi?name=Ntab&genome= lncRNA SLC1A2 apoptosis up Homo sapiens central nervous system 21110225 9606 6506 EAAT2|GLT-1 HGNC:10940|MIM:600300|Ensembl:ENSG00000110436|HPRD:02625|Vega:OTTHUMG00000044391 11 11p13-p12 solute carrier family 1 (glial high affinity glutamate transporter), member 2 protein-coding solute carrier family 1 (glial high affinity glutamate transporter), member 2 excitatory amino acid tr Fragments of Ntab act as enhancers of EAAT2/GLT-1 transcription. Expression of EAAT2/GLT-1 is perturbed in various acute and chronic brain diseases eventually allowing for the onset of neurotoxic extracellular glutamate concentrations and subsequent excitotoxic neuronal cell death. 540 p53-mRNA http://www.lncrnadb.org/p53mrna/ lncRNA HTATIP2 apoptosis Homo sapiens hepatocellular carcinoma cell 18519672 9606 10553 CC3|SDR44U1|TIP30 HGNC:16637|MIM:605628|Ensembl:ENSG00000109854|HPRD:09288|Vega:OTTHUMG00000166015 11 11p15.1 HIV-1 Tat interactive protein 2, 30kDa protein-coding HIV-1 Tat interactive protein 2, 30kDa Tip30 is involved in cellular oxidative stress surveillance and induces apoptosis through stabilization of p53 mrna in hcc cells. 541 p53-mRNA http://www.lncrnadb.org/p53mrna/ lncRNA PITX1 apoptosis Homo sapiens mammary carcinoma cells 17762884 9606 5307 BFT|CCF|LBNBG|POTX|PTX1 HGNC:9004|MIM:602149|Ensembl:ENSG00000069011|HPRD:03688|Vega:OTTHUMG00000149983 5 5q31.1 paired-like homeodomain 1 protein-coding paired-like homeodomain 1 Increased p53 mrna expression was due to activation of the p53 promoter by hPitx1. Forced expression of hpitx1 resulted in cell-cycle arrest and p53-dependent apoptosis in p53-replete MCF-7 cells. Furthermore, hPitx1 stimulated the transcription of p53 target genes involved in cell-cycle arrest and apoptosis (p21 and ptgf-beta), again in a p53-dependent manner.Depletion of p53 by sirna dramatically attenuated hpitx1-induced apoptosis in MCF-7 cells. 542 p53-mRNA http://www.lncrnadb.org/p53mrna/ lncRNA apoptosis Homo sapiens ovarian carcinoma cells 8895543 9606 Cisplatin-induced apoptosis and p53 gene status were analyzed in human ovarian carcinoma. A 2-fold increase in p53 mRNA and protein amounts was observed in resistant cells as assessed by Northern and Western blots, respectively. 543 p53-mRNA http://www.lncrnadb.org/p53mrna/ lncRNA apoptosis Homo sapiens immune cells 9647779 9606 Moreover, we show that HDAC inhibitor-induced apoptosis is associated with early abrogation of gamma-IFN production by Th1 lymphocytes and with p53 mRNA downregulation. 544 p53-mRNA http://www.lncrnadb.org/p53mrna/ lncRNA apoptosis Homo sapiens breast cancer cells 10705995 9606 Progesterone increased p53 mRNA levels. These results demonstrate that progesterone at relative high physiological concentrations, but comparable to those seen in plasma during the third trimester of human pregnancy, exhibited a strong antiproliferative effect on breast cancer cells and induced apoptosis. 545 PANDA http://www.lncrnadb.org/Detail.aspx?TKeyID=267 lncRNA APAF1 apoptosis down Homo sapiens fibroblasts 21642992 9606 317 APAF-1|CED4 HGNC:576|MIM:602233|Ensembl:ENSG00000120868|HPRD:03755|Vega:OTTHUMG00000170214 12 12q23 apoptotic peptidase activating factor 1 protein-coding apoptotic peptidase activating factor 1 apoptotic protease-activa PANDA depletion induced several genes encoding canonical activators of apoptosis, such as APAF1, BIK, FAS and LRDD. 546 PANDA lncRNA BCL2 apoptosis Homo sapiens lung cancer cell 25719249 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 We also showed that PANDAR-mediated growth regulation is in part due to the transcriptional modulation of Bcl-2 by interacting with NF-YA, thus affecting NSCLC cell apoptosis. Further experiments demonstrated that PANDAR expression was induced by p53, and chromatin immunoprecipitation (ChIP) assays confirmed that PANDAR was a direct transcriptional target of p53 in NSCLC cells. 547 PANDA http://www.lncrnadb.org/Detail.aspx?TKeyID=267 lncRNA BIK apoptosis down Homo sapiens fibroblasts 21642992 9606 638 BIP1|BP4|NBK HGNC:1051|MIM:603392|Ensembl:ENSG00000100290|HPRD:04547|Vega:OTTHUMG00000150703 22 22q13.31 BCL2-interacting killer (apoptosis-inducing) protein-coding BCL2-interacting killer (apoptosis-inducing) apoptosis inducer NBK; ap PANDA depletion induced several genes encoding canonical activators of apoptosis, such as APAF2, BIK, FAS and LRDD. 548 PANDA http://www.lncrnadb.org/Detail.aspx?TKeyID=267 lncRNA FAS apoptosis down Homo sapiens fibroblasts 21642992 9606 355 ALPS1A|APO-1|APT1|CD95|FAS1|FASTM|TNFRSF6 HGNC:11920|MIM:134637|Ensembl:ENSG00000026103|HPRD:00609|Vega:OTTHUMG00000018701 10 10q24.1 Fas cell surface death receptor protein-coding Fas cell surface death receptor leucine-rich repeat and d PANDA depletion induced several genes encoding canonical activators of apoptosis, such as APAF4, BIK, FAS and LRDD. 549 PANDA http://www.lncrnadb.org/Detail.aspx?TKeyID=267 lncRNA NFYA apoptosis down Homo sapiens fibroblasts 23222637 9606 4800 CBF-A|CBF-B|HAP2|NF-YA HGNC:7804|MIM:189903|HPRD:01793 6 6p21.3 nuclear transcription factor Y, alpha protein-coding nuclear transcription factor Y, alpha bcl-2-binding component 3 The depletion of PANDA substantially increases the occupancy of NF-YA at pro-apoptotic target genes such as CCNB1, FAS, BBC3 (PUMA) and PMAIP3 (NOXA). 550 PANDA lncRNA NFYA apoptosis Homo sapiens lung cancer cell 25719249 9606 4800 CBF-A|CBF-B|HAP2|NF-YA HGNC:7804|MIM:189903|HPRD:01793 6 6p21.3 nuclear transcription factor Y, alpha protein-coding nuclear transcription factor Y, alpha We also showed that PANDAR-mediated growth regulation is in part due to the transcriptional modulation of Bcl-2 by interacting with NF-YA, thus affecting NSCLC cell apoptosis. Further experiments demonstrated that PANDAR expression was induced by p53, and chromatin immunoprecipitation (ChIP) assays confirmed that PANDAR was a direct transcriptional target of p53 in NSCLC cells. 551 PANDA http://www.lncrnadb.org/Detail.aspx?TKeyID=267 lncRNA PIDD1 apoptosis down Homo sapiens fibroblasts 21642992 9606 55367 LRDD|PIDD HGNC:16491|MIM:605247|Ensembl:ENSG00000177595|HPRD:11284|Vega:OTTHUMG00000133306 11 11p15.5 p53-induced death domain protein 1 protein-coding p53-induced death domain protein 1 leucine-rich repeat and d PANDA depletion induced several genes encoding canonical activators of apoptosis, such as APAF4, BIK, FAS and LRDD. 552 PANDA lncRNA RASA1 apoptosis down Homo sapiens 25501747 9606 5921 CM-AVM|CMAVM|GAP|PKWS|RASA|RASGAP|p120GAP|p120RASGAP HGNC:9871|MIM:139150|Ensembl:ENSG00000145715|HPRD:00745|Vega:OTTHUMG00000162605 5 5q13.3 RAS p21 protein activator (GTPase activating protein) 1 protein-coding RAS p21 protein activator (GTPase activating protein) 1 We also show that forced expression of oncogenic Ras increases the expression of lncRNA PANDA (p21 associated ncRNA DNA damage activated), which is involved in the regulation of apoptosis. 553 PANDA lncRNA TP53 apoptosis up Homo sapiens lung cancer cell 25719249 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 We also showed that PANDAR-mediated growth regulation is in part due to the transcriptional modulation of Bcl-2 by interacting with NF-YA, thus affecting NSCLC cell apoptosis. Further experiments demonstrated that PANDAR expression was induced by p53, and chromatin immunoprecipitation (ChIP) assays confirmed that PANDAR was a direct transcriptional target of p53 in NSCLC cells. 554 PANDA http://www.lncrnadb.org/Detail.aspx?TKeyID=267 lncRNA apoptosis up Homo sapiens HeLa and caspase-3-deficient MCF-7 cell 22487937 9606 Our results reveal that basal RNA expression levels as well as the changes in the lncRNA expression rates during genotoxic stress-induced apoptosis were cell-type and/or DNA-damaging agent-specific. Generally, we found that some of the RNA molecules (HOTAIR and MALAT1) are down-regulated while many of them (lincRNA-p21, GAS5, MEG3, ANRIL, and ncRNA-CCND1) are up-regulated and some others (TUG1, UCA1, and PANDA) not affected. 555 pca3 http://valadkhanlab.org/web/cgi-bin/output_1.cgi?name=pca3&genome=huma lncRNA apoptosis Homo sapiens prostate adenocarcinoma cells 23130941 9606 983 CDC2|CDC28A|P34CDC2 HGNC:1722|Ensembl:ENSG00000170312|HPRD:00302|MIM:116940|Vega:OTTHUMG00000018290 10 10q21.1 cyclin-dependent kinase 1 protein coding cyclin-dependent kinase 1 cell cycle controller CDC PCA3 noncoding RNA is involved in the control of prostate-cancer cell survival and modulates androgen receptor signaling.PCA6 silencing decreases cell growth and survival and induces apoptotic cell death in prostate-cancer cells 556 PCAT-1 lncRNA apoptosis Homo sapiens prostate, Esophageal squamous cell carcinoma 25731728 9606 Prostate cancer-associated ncRNA transcript 1 (PCAT-1) is one of the lncRNAs involved in cell apoptosis and proliferation of prostate cancer. 557 pcgem1 http://www.lncrnadb.org/Detail.aspx?TKeyID=110 lncRNA CASP7 apoptosis down Homo sapiens prostate 16569192 9606 840 CASP-7|CMH-1|ICE-LAP3|LICE2|MCH3 HGNC:1508|MIM:601761|Ensembl:ENSG00000165806|HPRD:03457|Vega:OTTHUMG00000019076 10 10q25 caspase 7, apoptosis-related cysteine peptidase protein-coding caspase 7, apoptosis-related cysteine peptidase ADP-ribosyltransferase (N This study demonstrates that PCGEM1 overexpression in LNCaP cell culture model results in the inhibition of apoptosis induced by doxorubicin (DOX). Induction of p53 and p21(Waf1/Cip1) by DOX were delayed in LNCaP cells stably overexpressing PCGEM1 (LNCaP-PCGEM1 cells) compared to control LNCaP cells. The protein levels of cleaved caspase 7, and cleaved PARP were attenuated in DOXtreated LNCaP-PCGEM1 cells compared to control LNCaP cells. Similar results were observed in LNCaP cells transiently overexpressing PCGEM1. The inhibition of PARP cleavage by PCGEM1 overexpression was also observed in LNCaP-PCGEM1 cells incubated with etoposide and sodium selenite. 558 pcgem1 http://www.lncrnadb.org/Detail.aspx?TKeyID=110 lncRNA PARP1 apoptosis down Homo sapiens prostate 16569192 9606 142 ADPRT|ADPRT 1|ADPRT1|ARTD1|PARP|PARP-1|PPOL|pADPRT-1 HGNC:270|MIM:173870|Ensembl:ENSG00000143799|HPRD:01435|Vega:OTTHUMG00000037556 1 1q41-q42 poly (ADP-ribose) polymerase 1 protein-coding poly (ADP-ribose) polymerase 1 ADP-ribosyltransferase (N This study demonstrates that PCGEM1 overexpression in LNCaP cell culture model results in the inhibition of apoptosis induced by doxorubicin (DOX). Induction of p53 and p21(Waf1/Cip1) by DOX were delayed in LNCaP cells stably overexpressing PCGEM1 (LNCaP-PCGEM1 cells) compared to control LNCaP cells. The protein levels of cleaved caspase 7, and cleaved PARP were attenuated in DOXtreated LNCaP-PCGEM1 cells compared to control LNCaP cells. Similar results were observed in LNCaP cells transiently overexpressing PCGEM1. The inhibition of PARP cleavage by PCGEM1 overexpression was also observed in LNCaP-PCGEM1 cells incubated with etoposide and sodium selenite. 559 PCGEM1 lncRNA apoptosis Homo sapiens 19186008 9606 Phytosterol inhibition of PCGEM1 and cell growth and the overexpression of caveolin-1, suggests that poor disease prognosis anchors on the ability of caveolin-1 to regulate downstream oncogene(s) and apoptosis genes. 560 PlncRNA-1 http://www.ncbi.nlm.nih.gov/gene/?term=PlncRNA-1 lncRNA apoptosis Homo sapiens LNCaP and LNCaP-AI cell lines 22264502 9606 Silencing of PlncRNA-1 significantly reduced cell proliferation and induced apoptosis in CaP cell lines LNCaP and LNCaP-AI. 561 PlncRNA-1 lncRNA apoptosis Homo sapiens esophageal squamous cell 24337686 9606 PlncRNA-1 is one of lncRNAs that is associated with cell apoptosis and proliferation of prostate cancer. 562 PRNCR1 lncRNA AR apoptosis up Homo sapiens 23948400 9606 367 AIS|DHTR|HUMARA|HYSP1|KD|NR3C4|SBMA|SMAX1|TFM HGNC:644|MIM:313700|Ensembl:ENSG00000169083|HPRD:02437|Vega:OTTHUMG00000021740 X Xq12 androgen receptor protein-coding androgen receptor After transfected with PRNCR1-siRNA to silence the PRNCR1 mRNA expression, the C4-2 cells showed the inhibited expression of AR protein, the depressed proliferation and invasion abilities and the increased apoptosis rate. 563 PVT1 lncRNA MYC apoptosis down Homo sapiens malignant pleural mesothelioma 24926545 9606 4609 MRTL|MYCC|bHLHe39|c-Myc HGNC:7553|MIM:190080|Ensembl:ENSG00000136997|HPRD:01818|Vega:OTTHUMG00000128475 8 8q24.21 v-myc avian myelocytomatosis viral oncogene homolog protein-coding v-myc avian myelocytomatosis viral oncogene homolog Frequent coamplification and cooperation between C-MYC and PVT1 oncogenes promote malignant pleural mesothelioma. 564 PVT1 lncRNA apoptosis Homo sapiens breast and ovarian cancer cell lines 17908964 9606 Inhibition of PVT1 expression also induced a strong apoptotic response in cell lines in which it was overexpressed but not in lines in which it was not amplified/overexpressed. 565 PVT1 lncRNA apoptosis Homo sapiens colorectal 24196785 9606 Colorectal cancer (CRC) cells transfected with PVT-1 siRNA exhibited significant loss of their proliferation and invasion capabilities. In these cells, the TGF-¦Âsignalling pathway and apoptotic signals were significantly activated. 566 RN7SK http://www.lncrnadb.org/Detail.aspx?TKeyID=190 lncRNA apoptosis Homo sapiens cervical cancer cells 16152622 9606 SiRNA depletion of 7SK snRNA induces apoptosis but does not affect expression of the HIV-1 LTR or P-TEFb-dependent cellular genes. 567 RP11-296A18.3 lncRNA FAF1 apoptosis up Homo sapiens 25280944 9606 11124 HFAF1s|UBXD12|UBXN3A|hFAF1 HGNC:3578|MIM:604460|Ensembl:ENSG00000185104|HPRD:05124 1 1p33 Fas (TNFRSF6) associated factor 1 protein-coding Fas (TNFRSF6) associated factor 1 Interestingly, we found that Fas-associated protein factor-1 (FAF1), which potentiates the Fas-mediated apoptosis and its nearby enhancer-like lncRNA RP11-296A18.3, were highly expressed in the degenerative discs. Subsequent qRT-PCR results confirmed the changes. 568 sfRNA lncRNA IRF3 apoptosis down Homo sapiens 23755934 9606 3661 - HGNC:6118|MIM:603734|Ensembl:ENSG00000126456|HPRD:04769|Vega:OTTHUMG00000183287 19 19q13.3-q13.4 interferon regulatory factor 3 protein-coding interferon regulatory factor 3 Transfection of sfRNA into JEV-infected cells also reduced phosphorylation of interferon regulatory factor-3 (IRF-3), the IFN-¦Â upstream regulator, and blocked roughly 30% of IRF-3 nuclear localization. these results suggest that sfRNA plays a role against host-cell antiviral responses, prevents cells from undergoing apoptosis, and thus contributes to viral persistence 569 SPRY4-IT1 lncRNA DGAT2 apoptosis up Homo sapiens melanoma 25344859 9606 84649 ARAT|GS1999FULL HGNC:16940|MIM:606983|Ensembl:ENSG00000062282|HPRD:07376|Vega:OTTHUMG00000165338 11 11q13.5 diacylglycerol O-acyltransferase 2 protein-coding diacylglycerol O-acyltransferase 2 SPRY4-IT1 knockdown increases the accumulation of lipin2 protein and upregulate the expression of diacylglycerol O-acyltransferase 2 (DGAT2) an enzyme involved in the conversion of DAG to triacylglycerol (TAG).Together, these results suggest the possibility that SPRY4-IT1 knockdown may induce apoptosis via lipin 2-mediated alterations in lipid metabolism leading to cellular lipotoxicity. 570 SPRY4-IT1 lncRNA EZH2 apoptosis down Homo sapiens lung cancer 24967960 9606 2146 ENX-1|ENX1|EZH1|EZH2b|KMT6|KMT6A|WVS|WVS2 HGNC:3527|MIM:601573|Ensembl:ENSG00000106462|HPRD:03342|Vega:OTTHUMG00000158973 7 7q35-q36 enhancer of zeste 2 polycomb repressive complex 2 subunit protein-coding enhancer of zeste 2 polycomb repressive complex 2 subunit SPRY4-IT1 is derived from an intron within SPRY4, and is upregulated in melanoma cells; knockdown of its expression leads to cell growth arrest, invasion inhibition, and elevated rates of apoptosis.In this study, we showed that epigenetic silencing of lncRNA SPRY4 intronic transcript 1 (SPRY4-IT1) occurs in non-small-cell lung cancer (NSCLC) cells through direct transcriptional repression mediated by the Polycomb group protein enhancer of zeste homolog 2(EZH2). 571 SPRY4-IT1 lncRNA LPIN2 apoptosis up Homo sapiens melanoma 25344859 9606 9663 - HGNC:14450|MIM:605519|Ensembl:ENSG00000101577|HPRD:16114|Vega:OTTHUMG00000131508 18 18p11.31 lipin 2 protein-coding lipin 2 SPRY4-IT1 knockdown increases the accumulation of lipin2 protein and upregulate the expression of diacylglycerol O-acyltransferase 2 (DGAT2) an enzyme involved in the conversion of DAG to triacylglycerol (TAG).Together, these results suggest the possibility that SPRY4-IT1 knockdown may induce apoptosis via lipin 2-mediated alterations in lipid metabolism leading to cellular lipotoxicity. 572 SPRY4-IT1 http://www.lncrnadb.org/Detail.aspx?TKeyID=265 lncRNA SPRY4 apoptosis down Homo sapiens melanoma cells 21558391 9606 81848 HH17 HGNC:15533|MIM:607984|Ensembl:ENSG00000187678|HPRD:10466|Vega:OTTHUMG00000129663 5 5q31.3 sprouty homolog 4 (Drosophila) protein-coding sprouty homolog 4 (Drosophila) protein sprouty homolog 4 SPRY4-IT1 RNAi knockdown results in defects in cell growth, differentiation, and higher rates of apoptosis in melanoma cell lines. We found that although the expression of both SPRY4-IT1 and SPRY4.2 varied considerably between patients samples, their relative expression levels were highly correlated (R = 0.95, Pearson correlation; Supplementary Fig. S8). 573 SPRY4-IT1 lncRNA apoptosis Homo sapiens HTR-8/SVneo 24223182 9606 The results showed that SPRY4-IT1 knockdown enhanced the cell migration and proliferation, and reduced the response of cells to apoptosis. However, exogenous SPRY4-IT1 overexpression significantly decreased the cell migration and proliferation, while increased cell apoptosis. 574 SPRY4-IT1 lncRNA apoptosis Homo sapiens prostate 25307116 9606 AK024556 (SPRY4-IT1) was highly up-regulated in human prostate cancer cell line PC3 but not in LNCaP, and siRNA knockdown of SPRY4-IT1 in PC3 cells inhibited cell proliferation and invasion and increased cell apoptosis. 575 sra http://www.lncrnadb.org/Detail.aspx?TKeyID=117 lncRNA apoptosis Homo sapiens breast cancer cells 20219889 9606 7113 PP9284|PRSS10 HGNC:11876|Ensembl:ENSG00000184012|HPRD:03637|MIM:602060|Vega:OTTHUMG00000086762 21 21q22.3 transmembrane protease, serine 2 protein coding transmembrane protease, serine 2 epitheliasin; serine prot That SRA RNA levels might affect some biological functions, such as proliferation, apoptosis, steroidogenesis, and myogenesis, has been reported. 576 T-ALL-R-lncR1 lncRNA CASP3 apoptosis down Homo sapiens T-cell acute lymphoblastic leukemia 23906015 9606 836 CPP32|CPP32B|SCA-1 HGNC:1504|MIM:600636|Ensembl:ENSG00000164305|HPRD:02799|Vega:OTTHUMG00000133681 4 4q34 caspase 3, apoptosis-related cysteine peptidase protein-coding caspase 3, apoptosis-related cysteine peptidase T-ALL-R-LncR1 knockdown predisposed Jurkat cells to undergo pro-apoptotic factor Par-4-induced apoptosis. Further studies revealed that T-ALL-R-LncR1 knockdown facilitated the formation of a Par-4/THAP1 protein complex, resulting in the activation of caspase-3 and an increase of pro-apoptotic Smac protein in T-ALL cells. 577 T-ALL-R-lncR1 lncRNA DIABLO apoptosis down Homo sapiens T-cell acute lymphoblastic leukemia 23906015 9606 56616 DFNA64|SMAC HGNC:21528|MIM:605219|Ensembl:ENSG00000184047|HPRD:05560|Vega:OTTHUMG00000157014 12 12q24.31 diablo, IAP-binding mitochondrial protein protein-coding diablo, IAP-binding mitochondrial protein T-ALL-R-LncR1 knockdown predisposed Jurkat cells to undergo pro-apoptotic factor Par-4-induced apoptosis. Further studies revealed that T-ALL-R-LncR1 knockdown facilitated the formation of a Par-4/THAP1 protein complex, resulting in the activation of caspase-3 and an increase of pro-apoptotic Smac protein in T-ALL cells. 578 T-ALL-R-lncR1 lncRNA PAWR apoptosis down Homo sapiens T-cell acute lymphoblastic leukemia 23906015 9606 5074 PAR4|Par-4 HGNC:8614|MIM:601936|HPRD:09051 12 12q21 PRKC, apoptosis, WT1, regulator protein-coding PRKC, apoptosis, WT1, regulator T-ALL-R-LncR1 knockdown predisposed Jurkat cells to undergo pro-apoptotic factor Par-4-induced apoptosis. Further studies revealed that T-ALL-R-LncR1 knockdown facilitated the formation of a Par-4/THAP1 protein complex, resulting in the activation of caspase-3 and an increase of pro-apoptotic Smac protein in T-ALL cells. 579 T-ALL-R-lncR1 lncRNA THAP1 apoptosis down Homo sapiens T-cell acute lymphoblastic leukemia 23906015 9606 55145 DYT6 HGNC:20856|MIM:609520|Ensembl:ENSG00000131931|HPRD:15496|Vega:OTTHUMG00000165276 8 8p11.21 THAP domain containing, apoptosis associated protein 1 protein-coding THAP domain containing, apoptosis associated protein 1 T-ALL-R-LncR1 knockdown predisposed Jurkat cells to undergo pro-apoptotic factor Par-4-induced apoptosis. Further studies revealed that T-ALL-R-LncR1 knockdown facilitated the formation of a Par-4/THAP1 protein complex, resulting in the activation of caspase-3 and an increase of pro-apoptotic Smac protein in T-ALL cells. 580 TINCR lncRNA CDKN1A apoptosis Homo sapiens gastric carcinoma 25728677 9606 1026 CAP20|CDKN1|CIP1|MDA-6|P21|SDI1|WAF1|p21CIP1 HGNC:1784|MIM:116899|Ensembl:ENSG00000124762|HPRD:00298|Vega:OTTHUMG00000014603 6 6p21.2 cyclin-dependent kinase inhibitor 1A (p21, Cip1) protein-coding cyclin-dependent kinase inhibitor 1A (p21, Cip1) Mechanistic analyses indicated that TINCR could bind to STAU1 (staufen1) protein, and influence KLF2 mRNA stability and expression, then KLF2 regulated cyclin-dependent kinase genes CDKN1A/P21 and CDKN2B/P15 transcription and expression, thereby affecting the proliferation and?apoptosis?of GC cells. 581 TINCR lncRNA CDKN2B apoptosis Homo sapiens gastric carcinoma 25728677 9606 1030 CDK4I|INK4B|MTS2|P15|TP15|p15INK4b HGNC:1788|MIM:600431|Ensembl:ENSG00000147883|HPRD:02696|Vega:OTTHUMG00000019691 9 9p21 cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) protein-coding cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) Mechanistic analyses indicated that TINCR could bind to STAU1 (staufen1) protein, and influence KLF2 mRNA stability and expression, then KLF2 regulated cyclin-dependent kinase genes CDKN1A/P21 and CDKN2B/P15 transcription and expression, thereby affecting the proliferation and?apoptosis?of GC cells. 582 TINCR lncRNA KLF2 apoptosis Homo sapiens gastric carcinoma 25728677 9606 10365 LKLF HGNC:6347|MIM:602016|Ensembl:ENSG00000127528|HPRD:03602|Vega:OTTHUMG00000182330 19 19p13.11 Kruppel-like factor 2 protein-coding Kruppel-like factor 2 Mechanistic analyses indicated that TINCR could bind to STAU1 (staufen1) protein, and influence KLF2 mRNA stability and expression, then KLF2 regulated cyclin-dependent kinase genes CDKN1A/P21 and CDKN2B/P15 transcription and expression, thereby affecting the proliferation and?apoptosis?of GC cells. 583 TINCR lncRNA SP1 apoptosis Homo sapiens gastric carcinoma 25728677 9606 6667 - HGNC:11205|MIM:189906|Ensembl:ENSG00000185591|HPRD:01796|Vega:OTTHUMG00000170047 12 12q13.1 Sp1 transcription factor protein-coding Sp1 transcription factor We also revealed that TINCR overexpression is induced by nuclear transcription factor SP1. Silencing TINCR expression inhibited cell proliferation, colony formation, tumorigenicity and?apoptosis?promotion, whereas TINCR overexpression promoted cell growth, as documented in the SGC7901 and BGC823 cell lines. 584 TINCR lncRNA STAU1 apoptosis Homo sapiens gastric carcinoma 25728677 9606 6780 PPP1R150|STAU HGNC:11370|MIM:601716|Ensembl:ENSG00000124214|HPRD:03422|Vega:OTTHUMG00000032691 20 20q13.1 staufen double-stranded RNA binding protein 1 protein-coding staufen double-stranded RNA binding protein 1 Mechanistic analyses indicated that TINCR could bind to STAU1 (staufen1) protein, and influence KLF2 mRNA stability and expression, then KLF2 regulated cyclin-dependent kinase genes CDKN1A/P21 and CDKN2B/P15 transcription and expression, thereby affecting the proliferation and?apoptosis?of GC cells. 585 TUG1 http://www.lncrnadb.org/Detail.aspx?TKeyID=120 lncRNA apoptosis up Homo sapiens HeLa and caspase-3-deficient MCF-7 cell 22487937 9606 Our results reveal that basal RNA expression levels as well as the changes in the lncRNA expression rates during genotoxic stress-induced apoptosis were cell-type and/or DNA-damaging agent-specific. Generally, we found that some of the RNA molecules (HOTAIR and MALAT1) are down-regulated while many of them (lincRNA-p21, GAS5, MEG3, ANRIL, and ncRNA-CCND1) are up-regulated and some others (TUG1, UCA1, and PANDA) not affected. 586 TUG1 http://www.lncrnadb.org/Detail.aspx?TKeyID=120 lncRNA apoptosis Homo sapiens bladder urothelial carcinoma cells 22961206 9606 Cell proliferation inhibition and apoptosis induction were observed in TUG1 siRNA-transfected bladder urothelial carcinoma T24 and 5637 cells. 587 TUG1 lncRNA apoptosis Homo sapiens osteosarcoma 23725133 9606 Furthermore, inhibition of TUG1 expression significantly promoted osteosarcoma cell apoptosis. 588 uc.73A lncRNA apoptosis Homo sapiens colon cancer cells 22664915 9606 Depletion of uc.73A ncRNA resulted in reduced cellular proliferation of COLO-320 cells and an increase in sub-G1 cells, suggesting higher apoptosis rates. Thus, uc.73A(P) could act as an oncogene by increasing the number of malignant cells as a consequence of reduced apoptosis. 589 uc002mbe.2 http://www.ncbi.nlm.nih.gov/gene/?term=uc002mbe.2++human lncRNA apoptosis Homo sapiens Hepatocellular carcinoma Huh7 23643933 9606 8743 PRP|TSA|PRX2|PTX1|TPX1|NKEFB|PRXII|TDPX1|NKEF-B|HEL-S-2a HGNC:9353|Ensembl:ENSG00000167815|HPRD:02763|MIM:600538|Vega:OTTHUMG00000134285 19 19p13.2 peroxiredoxin 2 protein coding peroxiredoxin 2 Knockdown the expression of uc002mbe.2 significantly reduced TSA-induced apoptosis of Huh7cells. 590 UCA1 lncRNA CEBPA apoptosis down Homo sapiens bladder 24648007 9606 1050 C/EBP-alpha|CEBP HGNC:1833|MIM:116897|Ensembl:ENSG00000245848|HPRD:00296|Vega:OTTHUMG00000161461 19 19q13.1 CCAAT/enhancer binding protein (C/EBP), alpha protein-coding CCAAT/enhancer binding protein (C/EBP), alpha Upregulation of long non-coding RNA urothelial carcinoma associated 1 by CCAAT/enhancer binding protein ¦Á contributes to bladder cancer cell growth and reduced apoptosis.Electrophoretic mobility shift assay and chromatin immunoprecipitation assay indicated that C/EBP¦Á bound to the lncRNA-UCA1 core promoter region in vitro and in vivo. 591 UCA1 lncRNA HIF1A apoptosis down Homo sapiens bladder 24737584 9606 3091 HIF-1A|HIF-1alpha|HIF1|HIF1-ALPHA|MOP1|PASD8|bHLHe78 HGNC:4910|MIM:603348|Ensembl:ENSG00000100644|HPRD:04517|Vega:OTTHUMG00000140344 14 14q23.2 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) lncRNA-UCA1 upregulation increased cell proliferation, migration, and invasion and inhibited apoptosis.The underlying mechanism of hypoxia-upregulated lncRNA-UCA1 expression was that HIF-1¦Á specifically bound to HREs in the lncRNA-UCA1 promoter. 592 UCA1 http://www.ncbi.nlm.nih.gov/gene/652995 lncRNA apoptosis up Homo sapiens HeLa and caspase-3-deficient MCF-7 cell 22487937 9606 Our results reveal that basal RNA expression levels as well as the changes in the lncRNA expression rates during genotoxic stress-induced apoptosis were cell-type and/or DNA-damaging agent-specific. Generally, we found that some of the RNA molecules (HOTAIR and MALAT1) are down-regulated while many of them (lincRNA-p21, GAS5, MEG3, ANRIL, and ncRNA-CCND1) are up-regulated and some others (TUG1, UCA1, and PANDA) not affected. 593 UCA1 http://www.lncrnadb.org/Detail.aspx?TKeyID=121 lncRNA apoptosis Homo sapiens bladder cancer cells 22576688 9606 Overexpression of UCA1a(CUDR) could antagonize cell apoptosis induced by cisplatin and promote the tumorigenicity of UM-UC-2 cells in vivo. 594 UCA1 lncRNA apoptosis Homo sapiens colorectal cancer 24977734 9606 UCA1 was found to influence the proliferation, apoptosis and cell cycle progression of CRC cells. 595 URH lncRNA ZAK apoptosis down Homo sapiens hepatocellular carcinoma 25013376 9606 51776 AZK|MLK7|MLT|MLTK|MRK|mlklak|pk MIM:609479|Ensembl:ENSG00000091436|HPRD:11791|Vega:OTTHUMG00000132297 2 2q24.2 sterile alpha motif and leucine zipper containing kinase AZK protein-coding - We concluded that high URHC expression can promote cell proliferation and inhibit apoptosis by repressing ZAK expression through inactivation of the ERK/MAPK pathway. 596 Xist http://www.lncrnadb.org/Detail.aspx?TKeyID=122 lncRNA DNMT1 apoptosis Homo sapiens embryonic stem cells 8769643 9606 1786 ADCADN|AIM|CXXC9|DNMT|HSN1E|MCMT HGNC:2976|MIM:126375|Ensembl:ENSG00000130816|HPRD:00532|Vega:OTTHUMG00000180397 19 19p13.2 DNA (cytosine-5-)-methyltransferase 1 protein-coding DNA (cytosine-5-)-methyltransferase 1 In differentiated Dnmt mutant ES cells the activation of Xist expression correlated with a dramatic increase in apoptotic bodies, suggesting that Xist-mediated X chromosome inactivation may result in cell death and contribute to the embryonic lethality of the Dnmt mutation. 597 Xist lncRNA POU5F1 apoptosis down Homo sapiens 24945968 9606 5460 OCT3|OCT4|OTF-3|OTF3|OTF4|Oct-3|Oct-4 HGNC:9221|MIM:164177|Ensembl:ENSG00000204531|HPRD:01252|Vega:OTTHUMG00000031206 6 6p21.31 POU class 5 homeobox 1 protein-coding POU class 5 homeobox 1 We observed higher rates of blastocyst formation (P? 0.05). 1283 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA GAS5 apoptosis down Homo sapiens 23933812 9606 60674 NCRNA00030|SNHG2 HGNC:16355|MIM:608280|Ensembl:ENSG00000234741 1 1q25.1 growth arrest-specific 5 (non-protein coding) ncRNA growth arrest-specific 5 (non-protein coding) Using the lncRNA RT-PCR (reverse transcription-polymerase chain reaction) array carrying 83 human disease-related lncRNAs, we show that miR-21 is capable of suppressing the lncRNA growth arrest-specific 5 (GAS5). Of interest, GAS5 can also repress miR-21 expression. 1284 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA GAS5 apoptosis Homo sapiens osteoarthritis 25196583 9606 60674 NCRNA00030|SNHG2 HGNC:16355|MIM:608280|Ensembl:ENSG00000234741 1 1q25.1 growth arrest-specific 5 (non-protein coding) ncRNA growth arrest-specific 5 (non-protein coding) Together,these results show that GAS5 contributes to the pathogenesis of OA by acting as a negative regulator of miR-21 and thereby regulating cell survival. 1285 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA MKI67 apoptosis down Homo sapiens tongue squamous cell 21426775 9606 4288 KIA|MIB-|MIB-1|PPP1R105 HGNC:7107|MIM:176741|Ensembl:ENSG00000148773|HPRD:08902|Vega:OTTHUMG00000019255 10 10q26.2 marker of proliferation Ki-67 protein-coding marker of proliferation Ki-67 MiRNA-21 expression was decreased in miRNA-21 antisense oligonucleotide (ASODN) group. The survival rate of Tb 3.1 cells with AS-miRNA-21 transfection was significantly suppressed (F = 27.02, P = 0.00) and early phase apoptosis (F = 26.641, P = 0.001) induced in Tb 3.1 cell. Ki67, Bcl-2, MMP-2 and MMP-9 protein were down regulated while PTEN and TIMP-1 protein expression was increased. 1286 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA MMP2 apoptosis down Homo sapiens tongue squamous cell 21426775 9606 4313 CLG4|CLG4A|MMP-II|MONA|TBE-1 HGNC:7166|MIM:120360|Ensembl:ENSG00000087245|HPRD:00386|Vega:OTTHUMG00000133202 16 16q13-q21 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) protein-coding matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) MiRNA-21 expression was decreased in miRNA-21 antisense oligonucleotide (ASODN) group. The survival rate of Tb 3.1 cells with AS-miRNA-21 transfection was significantly suppressed (F = 27.02, P = 0.00) and early phase apoptosis (F = 26.641, P = 0.001) induced in Tb 3.1 cell. Ki67, Bcl-2, MMP-2 and MMP-9 protein were down regulated while PTEN and TIMP-1 protein expression was increased. 1287 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA MMP9 apoptosis down Homo sapiens tongue squamous cell 21426775 9606 4318 CLG4B|GELB|MANDP2|MMP-9 HGNC:7176|MIM:120361|Ensembl:ENSG00000100985|HPRD:00387|Vega:OTTHUMG00000033044 20 20q11.2-q13.1 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) protein-coding matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) MiRNA-21 expression was decreased in miRNA-21 antisense oligonucleotide (ASODN) group. The survival rate of Tb 3.1 cells with AS-miRNA-21 transfection was significantly suppressed (F = 27.02, P = 0.00) and early phase apoptosis (F = 26.641, P = 0.001) induced in Tb 3.1 cell. Ki67, Bcl-2, MMP-2 and MMP-9 protein were down regulated while PTEN and TIMP-1 protein expression was increased. 1288 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA NFKB1 apoptosis Homo sapiens 25000291 9606 4790 EBP-1|KBF1|NF-kB1|NF-kappa-B|NF-kappaB|NFKB-p105|NFKB-p50|NFkappaB|p105|p50 HGNC:7794|MIM:164011|Ensembl:ENSG00000109320|HPRD:01238|Vega:OTTHUMG00000161080 4 4q24 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 protein-coding nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 MPT64 protein from Mycobacterium tuberculosis inhibits apoptosis of macrophages through NF-kB-miRNA21-Bcl-2 pathway.Furthermore, the results provided strong evidence that bcl-2 up-regulation was positively controlled by miRNA-21. Finally, NF-¦ÊB was identified as the transcription factor for miRNA-21 using a ChIP assay. It can be concluded from our study that MPT64 could inhibit the apoptosis of RAW264.7 macrophages through the NF-¦ÊB-miRNA21-Bcl-2 pathway. 1289 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA PDCD4 apoptosis Homo sapiens breast cancer cells 17991735 9606 27250 H731 HGNC:8763|MIM:608610|Ensembl:ENSG00000150593|HPRD:10549|Vega:OTTHUMG00000019048 10 10q24 programmed cell death 4 (neoplastic transformation inhibitor) protein-coding programmed cell death 4 (neoplastic transformation inhibitor) neoplastic transformation The miR-21 microRNA is overexpressed in a wide variety of cancers and has been causally linked to cellular proliferation, apoptosis, and migration. Inhibition of mir-21 in MCF-7 breast cancer cells causes reduced cell growth. Using array expression analysis of MCF-7 cells depleted of miR-21, we have identified mRNA targets of mir-21 and have shown a link between miR-21 and the p53 tumor suppressor protein. We furthermore found that the tumor suppressor protein Programmed Cell Death 4 (PDCD4) is regulated by miR-21 and demonstrated that PDCD4 is a functionally important target for miR-21 in breast cancer cells. 1290 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA PDCD4 apoptosis Homo sapiens cardiac myocytes 19336275 9606 27250 H731 HGNC:8763|MIM:608610|Ensembl:ENSG00000150593|HPRD:10549|Vega:OTTHUMG00000019048 10 10q24 programmed cell death 4 (neoplastic transformation inhibitor) protein-coding programmed cell death 4 (neoplastic transformation inhibitor) To determine the potential roles of miRNAs in H(2)O(2)-mediated gene regulation and cellular injury, miR-21 expression was downregulated by miR-21 inhibitor and upregulated by pre-miR-21. H(2)O(2)-induced cardiac cell death and apoptosis were increased by miR-21 inhibitor and was decreased by pre-miR-21. Programmed cell death 4 (PDCD4) that was regulated by miR-21 and was a direct target of miR-21 in cardiac myocytes. 1291 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA PDCD4 apoptosis up Homo sapiens K562 cells 20141427 9606 27250 H731 HGNC:8763|MIM:608610|Ensembl:ENSG00000150593|HPRD:10549|Vega:OTTHUMG00000019048 10 10q24 programmed cell death 4 (neoplastic transformation inhibitor) protein-coding programmed cell death 4 (neoplastic transformation inhibitor) In this study, we found that the antisense inhibition of miR-21 in K562 cells suppressed cell migration, promoted cell apoptosis, and inhibited cell growth, and up-regulated the expression of the tumor suppressor gene PDCD4. Meanwhile, pre-miRNA-21 increased migration and decreased cell apoptosis without affecting proliferation. 1292 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA PDCD4 apoptosis Homo sapiens chronic myeloid leukemia cells 20148895 9606 27250 H731 HGNC:8763|MIM:608610|Ensembl:ENSG00000150593|HPRD:10549|Vega:OTTHUMG00000019048 10 10q24 programmed cell death 4 (neoplastic transformation inhibitor) protein-coding programmed cell death 4 (neoplastic transformation inhibitor) neoplastic transformation AMO-miR-21 sensitized leukemic K562 cells to ATO by inducing apoptosis partially due to its up-regulation of PDCD4 protein level. 1293 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA PDCD4 apoptosis down Homo sapiens HCC cell 20447717 9606 27250 H731 HGNC:8763|MIM:608610|Ensembl:ENSG00000150593|HPRD:10549|Vega:OTTHUMG00000019048 10 10q24 programmed cell death 4 (neoplastic transformation inhibitor) protein-coding programmed cell death 4 (neoplastic transformation inhibitor) We demonstrate that hepatocellular carcinoma is characterized by elevated levels of microRNA-21 and marked reductions of PTEN, PDCD4, and RECK expression. Silencing of PTEN and PDCD4 to prevent their induction by anti-microRNA-21 treatment led to decreased apoptosis and increased invasion, while silencing of RECK only led to increased invasion. 1294 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA PDCD4 apoptosis Homo sapiens Cardiovascular cell 20560046 9606 27250 H731 HGNC:8763|MIM:608610|Ensembl:ENSG00000150593|HPRD:10549|Vega:OTTHUMG00000019048 10 10q24 programmed cell death 4 (neoplastic transformation inhibitor) protein-coding programmed cell death 4 (neoplastic transformation inhibitor) MiR-21 is found to play important roles in vascular smooth muscle cell proliferation and apoptosis, cardiac cell growth and death, and cardiac fibroblast functions. Programmed cell death 4 (PDCD4), phosphatase and tensin homology deleted from chromosome 10 (PTEN), sprouty1 (SPRY1), and sprouty2 (SPRY2) are the current identified target genes of miR-21 that are involved in miR-21-mediated cardiovascular effects. 1295 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA PDCD4 apoptosis down Homo sapiens promyelocytic leukemia cells 20670480 9606 27250 H731 HGNC:8763|MIM:608610|Ensembl:ENSG00000150593|HPRD:10549|Vega:OTTHUMG00000019048 10 10q24 programmed cell death 4 (neoplastic transformation inhibitor) protein-coding programmed cell death 4 (neoplastic transformation inhibitor) neoplastic transformation Anti-miR-21 oligonucleotide enhances chemosensitivity of leukemic HL60 cells to arabinosylcytosine by inducing apoptosis. 1296 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA PDCD4 apoptosis up Homo sapiens glioblastoma-derived cells 21636706 9606 27250 H731 HGNC:8763|MIM:608610|Ensembl:ENSG00000150593|HPRD:10549|Vega:OTTHUMG00000019048 10 10q24 programmed cell death 4 (neoplastic transformation inhibitor) protein-coding programmed cell death 4 (neoplastic transformation inhibitor) neoplastic transformation Either downregulation of mir-21 or overexpression of its target, Pdcd4, in glioblastoma-derived cell lines leads to decreased proliferation, increased apoptosis, and decreased colony formation in soft agar. 1297 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA PDCD4 apoptosis down Homo sapiens 21763111 9606 27250 H731 HGNC:8763|MIM:608610|Ensembl:ENSG00000150593|HPRD:10549|Vega:OTTHUMG00000019048 10 10q24 programmed cell death 4 (neoplastic transformation inhibitor) protein-coding programmed cell death 4 (neoplastic transformation inhibitor) The respective targets of miRNA-21 and -106a, the tumor suppressors PTEN, PDCD4 and Rb with their pivotal role in cell cycle regulation, apoptosis and proliferation were found to be downregulated. 1298 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA PDCD4 apoptosis down Homo sapiens human glioblastoma cell lines cells 22353043 9606 27250 H731 HGNC:8763|MIM:608610|Ensembl:ENSG00000150593|HPRD:10549|Vega:OTTHUMG00000019048 10 10q24 programmed cell death 4 (neoplastic transformation inhibitor) protein-coding programmed cell death 4 (neoplastic transformation inhibitor) And over-expression of miR-21 in U251 cells abolished the enhancement of PDCD4 protein by UA. 1299 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA PDCD4 apoptosis down Homo sapiens malignant peripheral nerve sheath tumor cells 22526161 9606 27250 H731 HGNC:8763|MIM:608610|Ensembl:ENSG00000150593|HPRD:10549|Vega:OTTHUMG00000019048 10 10q24 programmed cell death 4 (neoplastic transformation inhibitor) protein-coding programmed cell death 4 (neoplastic transformation inhibitor) In MPNST cells, transfection of miR-21 inhibitor significantly increased caspase activity (P < 0.01), significantly suppressed cell growth (P < 0.05), and upregulated protein level of PDCD4, indicating that miR-21 inhibitor could induce cell apoptosis of MPNST cells. 1300 miR-21 hsa-miR-21-5p,hsa-miR-211-5p,hsa-miR-212-3p,hsa-miR-214-3p,hsa-miR-216 MIMAT0000076,MIMAT0000268,MIMAT0000269,MIMAT000027 miRNA PDCD4 apoptosis down Homo sapiens breast cancer cells 22547075 9606 27250 H731 HGNC:8763|MIM:608610|Ensembl:ENSG00000150593|HPRD:10549|Vega:OTTHUMG00000019048 10 10q24 programmed cell death 4 (neoplastic transformation inhibitor) protein-coding programmed cell death 4 (neoplastic transformation inhibitor) Induction of miR-21 may enable cancer cells to elude DNA damage-induced apoptosis and enhance the metastatic potential of breast cancer cells through repressing expression of PTEN and PDCD4. 1301 miR-21 hsa-miR-21-5p,hsa-miR-211-5p,hsa-miR-212-3p,hsa-miR-214-3p,hsa-miR-216 MIMAT0000076,MIMAT0000268,MIMAT0000269,MIMAT000027 miRNA PDCD4 apoptosis down Homo sapiens adventitial fibroblasts and myofibroblasts cells 22565856 9606 27250 H731 HGNC:8763|MIM:608610|Ensembl:ENSG00000150593|HPRD:10549|Vega:OTTHUMG00000019048 10 10q24 programmed cell death 4 (neoplastic transformation inhibitor) protein-coding programmed cell death 4 (neoplastic transformation inhibitor) Programmed cell death 4 (PDCD4), related to cell proliferation and apoptosis, was validated as a direct target of miR-21 by dual-luciferase reporter assay and gain and loss of function of miR-21 in AFs and MFs. PDCD4 knockdown with siRNA partly rescued the reduced proliferation with miR-21 inhibition and alleviated the increased apoptosis induced by miR-21 inhibition in AFs and MFs. 1302 miR-21 hsa-miR-21-5p,hsa-miR-211-5p,hsa-miR-212-3p,hsa-miR-214-3p,hsa-miR-216 MIMAT0000076,MIMAT0000268,MIMAT0000269,MIMAT000027 miRNA PDCD4 apoptosis down Homo sapiens cultured immortalized myometrial and leiomyoma cells 22728051 9606 27250 H731 HGNC:8763|MIM:608610|Ensembl:ENSG00000150593|HPRD:10549|Vega:OTTHUMG00000019048 10 10q24 programmed cell death 4 (neoplastic transformation inhibitor) protein-coding programmed cell death 4 (neoplastic transformation inhibitor) Loss of miR-21 also increased cleavage of caspase-3 (apoptosis marker) and increased phosphorylation of elongation factor-2 (marker of reduced translation) in both cell lines. Our studies indicate regulation of PDCD-4 expression is not a primary miR-21 function in leiomyomas, but instead miR-21 is able to impact cellular apoptosis and translation, through unknown targets, in a manner consistent with its involvement in the pathophysiology of uterine fibroids. 1303 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA PDCD4 apoptosis down Homo sapiens myocardial 23544605 9606 27250 H731 HGNC:8763|MIM:608610|Ensembl:ENSG00000150593|HPRD:10549|Vega:OTTHUMG00000019048 10 10q24 programmed cell death 4 (neoplastic transformation inhibitor) protein-coding programmed cell death 4 (neoplastic transformation inhibitor) Further study showed that miR-21 could protect myocardial apoptosis by specifically inhibiting its target programmed cell death 4 (PDCD4) expression. 1304 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA PDCD4 apoptosis down Homo sapiens renal cell carcinoma cells 23558936 9606 27250 H731 HGNC:8763|MIM:608610|Ensembl:ENSG00000150593|HPRD:10549|Vega:OTTHUMG00000019048 10 10q24 programmed cell death 4 (neoplastic transformation inhibitor) protein-coding programmed cell death 4 (neoplastic transformation inhibitor) Furthermore, miR-21 mimic or inhibitor significantly reduced or increased the expression of PDCD4 and TPM1. 1305 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA PDCD4 apoptosis down Homo sapiens ovarian 24472409 9606 27250 H731 HGNC:8763|MIM:608610|Ensembl:ENSG00000150593|HPRD:10549|Vega:OTTHUMG00000019048 10 10q24 programmed cell death 4 (neoplastic transformation inhibitor) protein-coding programmed cell death 4 (neoplastic transformation inhibitor) Using Western blot analysis, miR-21 knockdown enhanced the expression of tumor suppressor PDCD4, and attenuated apoptosis inhibitor c-IAP2. 1306 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA PDCD4 apoptosis down Homo sapiens Papillary thyroid carcinoma cell 24650454 9606 27250 H731 HGNC:8763|MIM:608610|Ensembl:ENSG00000150593|HPRD:10549|Vega:OTTHUMG00000019048 10 10q24 programmed cell death 4 (neoplastic transformation inhibitor) protein-coding programmed cell death 4 (neoplastic transformation inhibitor) Overexpression of miRNA-21 could significantly enhance proliferation and invasion and inhibit the apoptosis of TPC-1 cells. In addition, miRNA-21 and PDCD4 expression showed a significantly negative correlation in TPC-1 cells. 1307 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA PTEN apoptosis down Homo sapiens cholangiocarcinoma cell 16762633 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog MiR-21 modulates gemcitabine-induced apoptosis by phosphatase and tensin homolog deleted on chromosome 10 (PTEN)-dependent activation of PI 3-kinase signaling. Potential target genes that were modulated by selected miRNA were identified. 1308 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA PTEN apoptosis down Homo sapiens cholesteatoma cells 19672202 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog Up-regulation of hsa-miR-21 concurrent with down-regulation of potent tumor suppressor proteins PTEN and programmed cell death 4. these proteins control aspects of apoptosis, proliferation, invasion, and migration. 1309 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA PTEN apoptosis down Homo sapiens U251 20048743 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog To explore whether miR-21 can serve as a therapeutic target for glioblastoma, we downregulated miR-21 with a specific antisense oligonucleotide and found that apoptosis was induced and cell-cycle progression was inhibited in vitro in U251 (PTEN mutant) and LN229 (PTEN wild-type) GBM cells; xenograft tumors from antisense-treated U251 cells were suppressed in vivo. 1310 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA PTEN apoptosis down Homo sapiens endothelial cell 20153722 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog Western analysis demonstrated that PTEN, a known target of miR-21, was downregulated in HUVECs exposed to USS or transfected with pre-miR-21. Importantly, HUVECs overexpressing miR-21 had decreased apoptosis and increased eNOS phosphorylation and nitric oxide (NO(*)) production. These data demonstrate that shear stress forces regulate the expression of miRNAs in ECs, and that miR-21 influences endothelial biology by decreasing apoptosis and activating the NO(*) pathway. These studies advance our understanding of the mechanisms by which shear stress forces modulate vascular homeostasis. 1311 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA PTEN apoptosis down Homo sapiens HCC cell 20447717 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog We demonstrate that hepatocellular carcinoma is characterized by elevated levels of microRNA-21 and marked reductions of PTEN, PDCD4, and RECK expression. Silencing of PTEN and PDCD4 to prevent their induction by anti-microRNA-21 treatment led to decreased apoptosis and increased invasion, while silencing of RECK only led to increased invasion. 1312 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA PTEN apoptosis Homo sapiens Cardiovascular cell 20560046 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog MiR-21 is found to play important roles in vascular smooth muscle cell proliferation and apoptosis, cardiac cell growth and death, and cardiac fibroblast functions. Programmed cell death 4 (PDCD4), phosphatase and tensin homology deleted from chromosome 10 (PTEN), sprouty1 (SPRY1), and sprouty2 (SPRY2) are the current identified target genes of miR-21 that are involved in miR-21-mediated cardiovascular effects. 1313 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA PTEN apoptosis up Homo sapiens tongue squamous cell 21426775 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog MiRNA-21 expression was decreased in miRNA-21 antisense oligonucleotide (ASODN) group. The survival rate of Tb 3.1 cells with AS-miRNA-21 transfection was significantly suppressed (F = 27.02, P = 0.00) and early phase apoptosis (F = 26.641, P = 0.001) induced in Tb 3.1 cell. Ki67, Bcl-2, MMP-2 and MMP-9 protein were down regulated while PTEN and TIMP-1 protein expression was increased. 1314 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA PTEN apoptosis down Homo sapiens 21763111 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog The respective targets of miRNA-21 and -106a, the tumor suppressors PTEN, PDCD4 and Rb with their pivotal role in cell cycle regulation, apoptosis and proliferation were found to be downregulated. 1315 miR-21 hsa-miR-21-5p,hsa-miR-211-5p,hsa-miR-212-3p,hsa-miR-214-3p,hsa-miR-216 MIMAT0000076,MIMAT0000268,MIMAT0000269,MIMAT000027 miRNA PTEN apoptosis down Homo sapiens breast cancer cells 22547075 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog Induction of miR-21 may enable cancer cells to elude DNA damage-induced apoptosis and enhance the metastatic potential of breast cancer cells through repressing expression of PTEN and PDCD4. 1316 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA PTEN apoptosis down Homo sapiens cardiomyocytes 23710745 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog MicroRNA-21 reduced TNF-¦Á induced cardiomyocytes apoptosis [(23.42 ¡À 1.98)% vs. (78.37 ¡À 2.03)%, P < 0.05]. TNF-¦Á downregulated the expression of microRNA-21 and upregulated the mRNA and protein expressions of PTEN. Phosphorylation of PTEN, AKT and FOXO3a was enhanced in cardiomyocytes transfected with lenti-microRNA-21 (P < 0.05). TNF-¦Á also significantly activated the phosphorylation of PTEN, AKT and FOXO3a (P < 0.05). Compared with cardiomyocytes treated with TNF-¦Á (10 ng/ml), the phosphorylation of PTEN, AKT and FOXO3a as well as expression of pPTEN, pAKTser473, pFOXO3a and FasL were significantly suppressed in cardiomyocytes treated with lenti-microRNA-21 and TNF-¦Á (P < 0.05). Total AKT and FOXO3a were similar among all groups (P > 0.05). 1317 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA RB1 apoptosis down Homo sapiens 21763111 9606 5925 OSRC|PPP1R130|RB|p105-Rb|pRb|pp110 HGNC:9884|MIM:614041|Ensembl:ENSG00000139687|HPRD:01574|Vega:OTTHUMG00000016900 13 13q14.2 retinoblastoma 1 protein-coding retinoblastoma 1 The respective targets of miRNA-21 and -106a, the tumor suppressors PTEN, PDCD4 and Rb with their pivotal role in cell cycle regulation, apoptosis and proliferation were found to be downregulated. 1318 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA RECK apoptosis up Homo sapiens gastric cancer cells 18794849 9606 8434 ST15 HGNC:11345|MIM:605227|Ensembl:ENSG00000122707|HPRD:05567|Vega:OTTHUMG00000019898 9 9p13.3 reversion-inducing-cysteine-rich protein with kazal motifs protein-coding reversion-inducing-cysteine-rich protein with kazal motifs membrane-anchored glycopr More importantly, we showed that forced expression of miR-21 significantly enhanced cell proliferation and invasion in AGS cells, a human gastric cancer cell line, whereas knockdown of miR-21 by inhibitor caused a significant reduction in cell proliferation and a significant increase in apoptosis. Furthermore, we demonstrated that knockdown of miR-21 significantly decreased cell invasion and migration of AGS cells. Finally, we showed that RECK, a known tumor suppressor in gastric cancer, is a bona fide target of miR-21.? 1319 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA RECK apoptosis down Homo sapiens esophageal carcinoma 23504349 9606 8434 ST15 HGNC:11345|MIM:605227|Ensembl:ENSG00000122707|HPRD:05567|Vega:OTTHUMG00000019898 9 9p13.3 reversion-inducing-cysteine-rich protein with kazal motifs protein-coding reversion-inducing-cysteine-rich protein with kazal motifs miR-21 expression was increased significantly in ESCC tissues compared with NMAT. miR-21 down-regulation inhibits cell growth, cell invasion and induces cells to apoptosis. FASL, TIMP3 and RECK are direct targets of miR-21. 1320 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA SETD7 apoptosis up Homo sapiens human multiple myeloma cells 23247593 9606 80854 KMT7|SET7|SET7/9|SET9 HGNC:30412|MIM:606594|Ensembl:ENSG00000145391|HPRD:16226|Vega:OTTHUMG00000133385 4 4q28 SET domain containing (lysine methyltransferase) 7 protein-coding SET domain containing (lysine methyltransferase) 7 In U266 cells, berberine suppresses NF-¦ÊB nuclear translocation via Set9-mediated lysine methylation, leads to decrease in the levels miR21 and Bcl-2, which induces ROS generation and apoptosis. 1321 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA SPRY1 apoptosis Homo sapiens Cardiovascular cell 20560046 9606 10252 hSPRY1 HGNC:11269|MIM:602465|Ensembl:ENSG00000164056|HPRD:06782|Vega:OTTHUMG00000133071 4 4q28.1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) protein-coding sprouty homolog 1, antagonist of FGF signaling (Drosophila) MiR-21 is found to play important roles in vascular smooth muscle cell proliferation and apoptosis, cardiac cell growth and death, and cardiac fibroblast functions. Programmed cell death 4 (PDCD4), phosphatase and tensin homology deleted from chromosome 10 (PTEN), sprouty1 (SPRY1), and sprouty2 (SPRY2) are the current identified target genes of miR-21 that are involved in miR-21-mediated cardiovascular effects. 1322 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA SPRY2 apoptosis Homo sapiens Cardiovascular cell 20560046 9606 10253 hSPRY2 HGNC:11270|MIM:602466|Ensembl:ENSG00000136158|HPRD:03916|Vega:OTTHUMG00000017140 13 13q31.1 sprouty homolog 2 (Drosophila) protein-coding sprouty homolog 2 (Drosophila) MiR-21 is found to play important roles in vascular smooth muscle cell proliferation and apoptosis, cardiac cell growth and death, and cardiac fibroblast functions. Programmed cell death 4 (PDCD4), phosphatase and tensin homology deleted from chromosome 10 (PTEN), sprouty1 (SPRY1), and sprouty2 (SPRY2) are the current identified target genes of miR-21 that are involved in miR-21-mediated cardiovascular effects. 1323 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA STAT3 apoptosis up Homo sapiens CD4+ tumor cell 21085192 9606 6774 APRF|HIES HGNC:11364|MIM:102582|Ensembl:ENSG00000168610|HPRD:00026|Vega:OTTHUMG00000150645 17 17q21.31 signal transducer and activator of transcription 3 (acute-phase response factor) protein-coding signal transducer and activator of transcription 3 (acute-phase response factor) Stimulation of S¨¦zary cells or healthy CD4+ T cells with the common-¦Ã chain cytokine IL-21 results in a strong activation of STAT3, and subsequent upregulation of miR-21 expression. Both pri- and mature miR-21 expression are increased in S¨¦zary cells when compared with CD4+ T cells from healthy donors. Silencing of miR-21 in S¨¦zary cells results in increased apoptosis, suggesting a functional role for miR-21 in the leukomogenic process. Consequently, miR-21 might represent a therapeutic target for the treatment of SS. 1324 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA TIMP1 apoptosis up Homo sapiens tongue squamous cell 21426775 9606 7076 CLGI|EPA|EPO|HCI|TIMP HGNC:11820|MIM:305370|Ensembl:ENSG00000102265|HPRD:02371|Vega:OTTHUMG00000021447 X Xp11.3-p11.23 TIMP metallopeptidase inhibitor 1 protein-coding TIMP metallopeptidase inhibitor 1 MiRNA-21 expression was decreased in miRNA-21 antisense oligonucleotide (ASODN) group. The survival rate of Tb 3.1 cells with AS-miRNA-21 transfection was significantly suppressed (F = 27.02, P = 0.00) and early phase apoptosis (F = 26.641, P = 0.001) induced in Tb 3.1 cell. Ki67, Bcl-2, MMP-2 and MMP-9 protein were down regulated while PTEN and TIMP-1 protein expression was increased. 1325 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA TIMP3 apoptosis down Homo sapiens esophageal carcinoma 23504349 9606 7078 HSMRK222|K222|K222TA2|SFD HGNC:11822|MIM:188826|Ensembl:ENSG00000100234|HPRD:01785|Vega:OTTHUMG00000030784 22 22q12.3 TIMP metallopeptidase inhibitor 3 protein-coding TIMP metallopeptidase inhibitor 3 miR-21 expression was increased significantly in ESCC tissues compared with NMAT. miR-21 down-regulation inhibits cell growth, cell invasion and induces cells to apoptosis. FASL, TIMP3 and RECK are direct targets of miR-21. 1326 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA TNF apoptosis Homo sapiens cardiomyocytes 23710745 9606 7124 DIF|TNF-alpha|TNFA|TNFSF2 HGNC:11892|MIM:191160|Ensembl:ENSG00000232810|HPRD:01855|Vega:OTTHUMG00000031194 6 6p21.3 tumor necrosis factor protein-coding tumor necrosis factor MicroRNA-21 reduced TNF-¦Á induced cardiomyocytes apoptosis [(23.42 ¡À 1.98)% vs. (78.37 ¡À 2.03)%, P < 0.05]. TNF-¦Á downregulated the expression of microRNA-21 and upregulated the mRNA and protein expressions of PTEN. Phosphorylation of PTEN, AKT and FOXO3a was enhanced in cardiomyocytes transfected with lenti-microRNA-21 (P < 0.05). TNF-¦Á also significantly activated the phosphorylation of PTEN, AKT and FOXO3a (P < 0.05). Compared with cardiomyocytes treated with TNF-¦Á (10 ng/ml), the phosphorylation of PTEN, AKT and FOXO3a as well as expression of pPTEN, pAKTser473, pFOXO3a and FasL were significantly suppressed in cardiomyocytes treated with lenti-microRNA-21 and TNF-¦Á (P < 0.05). Total AKT and FOXO3a were similar among all groups (P > 0.05). 1327 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA TPM1 apoptosis down Homo sapiens breast cancer cells 17363372 9606 7168 C15orf13|CMD1Y|CMH3|HTM-alpha|LVNC9|TMSA HGNC:12010|MIM:191010|Ensembl:ENSG00000140416|HPRD:01839|Vega:OTTHUMG00000132803 15 15q22.1 tropomyosin 1 (alpha) protein-coding tropomyosin 1 (alpha) alpha-tropomyosin|cardiom MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1). Overexpression of TPM1 in breast cancer MCF-7 cells suppressed anchorage-independent growth. 1328 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA TPM1 apoptosis down Homo sapiens tongue squamous cell carcinomas cells 19509158 9606 7168 C15orf13|CMD1Y|CMH3|HTM-alpha|LVNC9|TMSA HGNC:12010|MIM:191010|Ensembl:ENSG00000140416|HPRD:01839|Vega:OTTHUMG00000132803 15 15q22.1 tropomyosin 1 (alpha) protein-coding tropomyosin 1 (alpha) alpha-tropomyosin|cardiom MiR-21 is an independent prognostic indicator for TSCC, and may play a role in TSCC development by inhibiting cancer cell apoptosis partly via TPM1 silencing. 1329 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA TPM1 apoptosis down Homo sapiens 23558936 9606 7168 C15orf13|CMD1Y|CMH3|HTM-alpha|LVNC9|TMSA HGNC:12010|MIM:191010|Ensembl:ENSG00000140416|HPRD:01839|Vega:OTTHUMG00000132803 15 15q22.1 tropomyosin 1 (alpha) protein-coding tropomyosin 1 (alpha) MiR-21 is overexpressed in RCC tissue and modulates the growth, apoptosis and cell cycle progression of RCC cells and regulates the expression of PDCD4 and TPM1. 1330 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA apoptosis up Homo sapiens cultured glioblastoma tumor tissue 16024602 9606 Knockdown of miR-21 in cultured glioblastoma cells triggers activation of caspases and leads to increased apoptotic cell death. 1331 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA apoptosis Homo sapiens A549 cell 18982517 9606 The results showed that AMO-miR-21, AMO-miR-16, and AMO-miR-181a inhibited A549 cell growth by inducing apoptosis and S-phase arrest. These inhibitory effects increased with dose and time. It was found that AMO-miR-21 down-regulated miR-21 expression in A549 cells. We conclude that miR-21, miR-16, and miR-181a are potential targets for lung cancer therapy, and specific AMOs can be a powerful technique for miRNA inhibition 1332 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA apoptosis Homo sapiens pancreatic cancer cells 19730150 9606 8434 ST15 HGNC:11345|MIM:605227|Ensembl:ENSG00000122707|HPRD:05567|Vega:OTTHUMG00000019898|M2D:hsa-miR-21 9 9p13.3 reversion-inducing-cysteine-rich protein with kazal motifs protein coding reversion-inducing-cysteine-rich protein with kazal motifs membrane-anchored glycopr Antisense inhibition of microRNA-21 or -221 arrests cell cycle, induces apoptosis, and sensitizes the effects of gemcitabine in pancreatic adenocarcinoma. 1333 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA apoptosis Homo sapiens 20693987 9606 When miR-21 was inactivated, the tumours regressed completely in a few days, partly as a result of apoptosis. These results demonstrate that tumours can become addicted to oncomiRs and support efforts to treat human cancers through pharmacological inactivation of miRNAs such as miR-21. 1334 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA apoptosis Homo sapiens 21139417 9606 MiR-21 is a miRNA that is overexpressed in most tumor types, and acts as an oncogene by targeting many tumor suppressor genes related to proliferation, apoptosis, and invasion. 1335 miR-21 hsa-miR-21-5p,hsa-miR-211-5p,hsa-miR-212-3p,hsa-miR-214-3p,hsa-miR-216 MIMAT0000076,MIMAT0000268,MIMAT0000269,MIMAT000027 miRNA apoptosis Homo sapiens glioblastoma cells 22528454 9606 Accumulating evidence indicated that downregulation of miR-21 in glioblastoma cells caused repression of growth and increased apoptosis, all of which could theoretically enhance the chemotherapeutic effects of cancer therapy. 1336 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA apoptosis Homo sapiens melanoma cells 22716245 9606 We show that downregulation of miR-21 in melanoma cell lines with high endogenous miR-21 expression induced apoptosis, whereas proliferation was not significantly altered. Upregulation of miR-21 in melanocytes resulted in increased proliferation and decreased apoptosis. 1337 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA apoptosis Homo sapiens right ventricular myocardial cells 22842854 9606 The TMZ-treated RVMCs showed less apoptosis and an increased expression of miR-21. 1338 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA apoptosis Homo sapiens glioma cells 22853427 9606 5728 BZS|DEC|CWS1|GLM2|MHAM|TEP1|MMAC1|PTEN1|10q23del HGNC:9588|HPRD:03431|MIM:601728 10 10q23.3 Down-regulation of microRNA-21 (miR-21) can induce cell apoptosis and reverse drug resistance in cancer treatments. 1339 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA apoptosis down Homo sapiens glioblastoma cells 22907752 9606 Silencing of hnRNPC lowered miR-21 levels, in turn increasing the expression of PDCD4, suppressing Akt and p70S6K activation, and inhibiting migratory and invasive activities. Silencing of hnRNPC reduced cell proliferation and enhanced etoposide-induced apoptosis. I 1340 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA apoptosis down Homo sapiens kidney cells 23151984 9606 Xu et al. provide new insights into the protective effects of delayed IPC and its inhibition of apoptosis by implicating a modulatory role for the microRNA miR-21. 1341 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA apoptosis down Homo sapiens Hepatocellular carcinoma cells 23232518 9606 The recombinant adenovirus inhibited the expression of miR-21 in HepG2 cells, and also depressed the proliferation of HepG2 cells and promoted the apoptosis. 1342 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA apoptosis Homo sapiens pancreatic cancer cells 23481326 9606 Targeting miR-21 for the therapy of pancreatic cancer.miR-21 depletion stopped the progression of a very aggressive model of PDA, to induce cell death by apoptosis 1343 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA apoptosis Homo sapiens atrial cell 23595377 9606 Samples of a trial tissue showed the abnormal pathohistological and ultrastructural changes, the accelerated fibrosis, and apoptosis with aging and/or in AF dogs. Compared to the adult group, the expressions of microRNAs-21 and -29 were significantly increased, whereas the expressions of microRNAs-1 and -133 showed obvious downregulation tendency in the aged group. 1344 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA apoptosis Homo sapiens pancreatic cancer cells 23726431 9606 MiR-21 levels increased in all cell lines grown in hypoxic conditions versus normoxia, whereas siRNA targeting HIF-1¦Á reduced miR-21 expression. Hypoxic conditions resulted in direct binding of HIF-1¦Á to the predicted binding site in miR-21. MiR-21 overexpression allows cells to avoid apoptosis in a hypoxic microenvironment. 1345 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA apoptosis down Homo sapiens non-small cell lung cancer cells 23777591 9606 Overexpression of miRNA-21 promotes radiation-resistance of non-small cell lung cancer.Decreased miRNA-21 expression promoted the apoptosis of A549 cells induced by irradiation. 1346 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA apoptosis down Homo sapiens colon cancer cell 24427170 9606 Recent studies showed that silencing of miR21 through use of a miR21 inhibitor (anti-miR21) affected viability, apoptosis and the cell cycle in colon cancer cells. We identified an anti-miR21 that targets miR21 to inhibit genes by both post-transcriptional gene silencing and transcriptional gene silencing in the cytoplasm and nucleus, respectively. Overexpression of anti-miR21 in colon cancer cells caused changes in miRNA expression levels. We found that treatment with anti-miR21 down-regulated expression of miR30, which is involved in angiogenesis. 1347 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA apoptosis down Homo sapiens T cell and macrophages 24577093 9606 79626 TNFAIP8L2 HGNC:26277|Ensembl:ENSG00000163154|HPRD:08029|MIM:612112|Vega:OTTHUMG00000012259 1 1q21.3 tumor necrosis factor, alpha-induced protein 8-like 2 protein coding tumor necrosis factor, alpha-induced protein 8-like 2 We report here that miR-21 is a direct target of nuclear factor-¦ÊB and could regulate Tipe2 expression in a Tipe2 coding region-dependent manner. In activated T cells and macrophages, Tipe2 expression was markedly downregulated, whereas miR-21 expression was upregulated. 1348 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA apoptosis Homo sapiens uterine cell 24706045 9606 Mounting evidence supports a functional role for miRNA as either indirect or direct regulators of gene expression which impacts the pathobiology of uterine fibroids. Specifically, miRNAs let-7, 200a, 200c, 93, 106b and 21 have been implicated in cellular proliferation, apoptosis, extracellular matrix turnover, angiogenesis and inflammation. Preliminary data provide evidence to suggest that respective in vitro miRNA expression in leiomyomata and myometrium is regulated by sex steroids. 1349 miR-210 hsa-miR-210-5p,hsa-miR-210-3p MIMAT0000267,MIMAT0026475 miRNA AIFM3 apoptosis down Homo sapiens hepatoma 22387901 9606 150209 AIFL HGNC:26398|Ensembl:ENSG00000183773|HPRD:08085|Vega:OTTHUMG00000150804 22 22q11.21 apoptosis-inducing factor, mitochondrion-associated, 3 protein-coding apoptosis-inducing factor, mitochondrion-associated, 3 Moreover, apoptosis-inducing factor, mitochondrion-associated, 3 (AIFM3) was identified as a direct target gene of miR-210. AIFM3 downregulation by siRNA attenuated radiation induced apoptosis in miR-210 downregulated hypoxic human hepatoma cells. 1350 miR-210 hsa-miR-210-5p,hsa-miR-210-3p MIMAT0000267,MIMAT0026475 miRNA BAX apoptosis down Homo sapiens pheochromocytoma cells 23591709 9606 581 BCL2L4 HGNC:959|MIM:600040|Ensembl:ENSG00000087088|HPRD:02498|Vega:OTTHUMG00000160476 19 19q13.3-q13.4 BCL2-associated X protein protein-coding BCL2-associated X protein We established an ex vivo model of HIE using oxygen-glucose deprivation (OGD) and demonstrated that miR-210 expression was upregulated in pheochromocytoma (PC12) cells after 4 h of OGD compared with normoxic controls. Furthermore, miR-210 suppressed cell apoptosis by inhibiting caspase activity and by regulating the balance between Bcl-2 and Bax levels. 1351 miR-210 hsa-miR-210-5p,hsa-miR-210-3p MIMAT0000267,MIMAT0026475 miRNA BAX apoptosis down Homo sapiens 24089674 9606 581 BCL2L4 HGNC:959|MIM:600040|Ensembl:ENSG00000087088|HPRD:02498|Vega:OTTHUMG00000160476 19 19q13.3-q13.4 BCL2-associated X protein protein-coding BCL2-associated X protein The results showed that microRNA-210, whose expression was downregulated in the brain 72?h after HI injury, suppressed neuronal apoptosis by inhibiting caspase activity and regulating the balance between bcl-2 and bax levels.Western blot analysis demonstrated that caspase-3, caspase-9, and bax protein levels were enhanced in miR-210 block rats and decreased in miR-210 overexpression rats compared to controls. In contrast, antiapoptotic bcl-2 expression behaved in an almost inverse manner 1352 miR-210 hsa-miR-210-5p,hsa-miR-210-3p MIMAT0000267,MIMAT0026475 miRNA BAX apoptosis Homo sapiens PC12 cell 25323830 9606 581 BCL2L4 HGNC:959|MIM:600040|Ensembl:ENSG00000087088|HPRD:02498|Vega:OTTHUMG00000160476 19 19q13.3-q13.4 BCL2-associated X protein protein-coding BCL2-associated X protein MiR-210 knockdown increased cell apoptosis by inducing caspase activity and regulating the balance between Bcl-2 and Bax levels. The present study demonstrated that miR-210 knockdown induced cell apoptosis using an ex vivo model of ischemic hypoxia (IH). Knockdown of miR-210 represents a potential novel therapeutic approach to combat neonatal IH. 1353 miR-210 hsa-miR-210-5p,hsa-miR-210-3p MIMAT0000267,MIMAT0026475 miRNA BCL2 apoptosis down Homo sapiens neuro 23108914 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Application of miR-210 antisenses simultaneously alleviated OGD-involved inhibition of Bcl-2 mRNA expression. In comparison, overexpression of miR-210 synergistically diminished OGD-caused inhibition of Bcl-2 mRNA expression and consequently induced greater cellular insults. Taken together, this study shows that OGD can induce miR-210 expression through activating HIF-1¦Á. And miR-210 can mediate hypoxia-induced neural apoptosis by targeting Bcl-2. 1354 miR-210 hsa-miR-210-5p,hsa-miR-210-3p MIMAT0000267,MIMAT0026475 miRNA BCL2 apoptosis down Homo sapiens pheochromocytoma cells 23591709 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 We established an ex vivo model of HIE using oxygen-glucose deprivation (OGD) and demonstrated that miR-210 expression was upregulated in pheochromocytoma (PC12) cells after 4 h of OGD compared with normoxic controls. Furthermore, miR-210 suppressed cell apoptosis by inhibiting caspase activity and by regulating the balance between Bcl-2 and Bax levels. 1355 miR-210 hsa-miR-210-5p,hsa-miR-210-3p MIMAT0000267,MIMAT0026475 miRNA BCL2 apoptosis up Homo sapiens 24089674 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 The results showed that microRNA-210, whose expression was downregulated in the brain 72?h after HI injury, suppressed neuronal apoptosis by inhibiting caspase activity and regulating the balance between bcl-2 and bax levels.Western blot analysis demonstrated that caspase-3, caspase-9, and bax protein levels were enhanced in miR-210 block rats and decreased in miR-210 overexpression rats compared to controls. In contrast, antiapoptotic bcl-2 expression behaved in an almost inverse manner 1356 miR-210 hsa-miR-210-5p,hsa-miR-210-3p MIMAT0000267,MIMAT0026475 miRNA BCL2 apoptosis Homo sapiens PC12 cell 25323830 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 MiR-210 knockdown increased cell apoptosis by inducing caspase activity and regulating the balance between Bcl-2 and Bax levels. The present study demonstrated that miR-210 knockdown induced cell apoptosis using an ex vivo model of ischemic hypoxia (IH). Knockdown of miR-210 represents a potential novel therapeutic approach to combat neonatal IH. 1357 miR-210 hsa-miR-210-5p,hsa-miR-210-3p MIMAT0000267,MIMAT0026475 miRNA BNIP3 apoptosis down Homo sapiens neural progenitor cells 23688833 9606 664 NIP3 HGNC:1084|MIM:603293|HPRD:04482 10 10q26.3 BCL2/adenovirus E1B 19kDa interacting protein 3 protein-coding BCL2/adenovirus E1B 19kDa interacting protein 3 miR-210 suppresses BNIP3 to protect against the apoptosis of neural progenitor cells.the over-expression of miR-210 decreased apoptosis in NPCs, and the inhibition of miR-210 expression remarkably increased the number of TUNEL-positive NPCs by 30% in response to hypoxia. 1358 miR-210 hsa-miR-210-5p,hsa-miR-210-3p MIMAT0000267,MIMAT0026475 miRNA CASP3 apoptosis up Homo sapiens glioma stem cell 24930954 9606 836 CPP32|CPP32B|SCA-1 HGNC:1504|MIM:600636|Ensembl:ENSG00000164305|HPRD:02799|Vega:OTTHUMG00000133681 4 4q34 caspase 3, apoptosis-related cysteine peptidase protein-coding caspase 3, apoptosis-related cysteine peptidase Moreover, knockdown of miR-210 led to increased apoptotic rate and Caspase-3/7 activity and decreased invasive capacity, reactive oxygen species (ROS) and lactate production and radioresistance in hypoxic GSCs. These findings suggest that miR-210 might be a potential therapeutic target to eliminate GSCs located in hypoxic niches. 1359 miR-210 hsa-miR-210-5p,hsa-miR-210-3p MIMAT0000267,MIMAT0026475 miRNA CASP7 apoptosis down Homo sapiens glioma stem cell 24930954 9606 840 CASP-7|CMH-1|ICE-LAP3|LICE2|MCH3 HGNC:1508|MIM:601761|Ensembl:ENSG00000165806|HPRD:03457|Vega:OTTHUMG00000019076 10 10q25 caspase 7, apoptosis-related cysteine peptidase protein-coding caspase 7, apoptosis-related cysteine peptidase Moreover, knockdown of miR-210 led to increased apoptotic rate and Caspase-3/7 activity and decreased invasive capacity, reactive oxygen species (ROS) and lactate production and radioresistance in hypoxic GSCs. These findings suggest that miR-210 might be a potential therapeutic target to eliminate GSCs located in hypoxic niches. 1360 miR-210 hsa-miR-210-5p,hsa-miR-210-3p MIMAT0000267,MIMAT0026475 miRNA CASP8AP2 apoptosis down Homo sapiens mesenchymal stem cells 19721136 9606 9994 CED-4|FLASH|RIP25 HGNC:1510|MIM:606880|HPRD:06048 6 6q15 caspase 8 associated protein 2 protein-coding caspase 8 associated protein 2 CASP8 associated protein Induction of FLASH/CASP8AP2 in miR-210 knocked-down (PC)MSCs resulted in increased cell apoptosis. 1361 miR-210 hsa-miR-210-5p,hsa-miR-210-3p MIMAT0000267,MIMAT0026475 miRNA CASP8AP2 apoptosis down Homo sapiens stem cell 22482882 9606 9994 CED-4|FLASH|RIP25 HGNC:1510|MIM:606880|HPRD:06048 6 6q15 caspase 8 associated protein 2 protein-coding caspase 8 associated protein 2 IPC enhances stem cell survival via the combined participation of hypoxia responsive miRs miR-107 and miR-210 via their respective putative target genes Pdcd10 and Casp8ap2. 1362 miR-210 hsa-miR-210-5p,hsa-miR-210-3p MIMAT0000267,MIMAT0026475 miRNA EFNA3 apoptosis down Homo sapiens cardiomyocytic cell 25016614 9606 1944 EFL2|EPLG3|Ehk1-L|LERK3 HGNC:3223|MIM:601381|Ensembl:ENSG00000143590|HPRD:03225|Vega:OTTHUMG00000035313 1 1q21-q22 ephrin-A3 protein-coding ephrin-A3 MiR-210 down-regulated its known targets, ephrin A3 and PTP1b, inhibiting apoptosis in cardiomyocytic cells. 1363 miR-210 hsa-miR-210-5p,hsa-miR-210-3p MIMAT0000267,MIMAT0026475 miRNA FGFRL1 apoptosis down Homo sapiens laryngocarcinoma cell 25639884 9606 53834 FGFR5|FHFR HGNC:3693|MIM:605830|Ensembl:ENSG00000127418|HPRD:16163|Vega:OTTHUMG00000118998 4 4p16 fibroblast growth factor receptor-like 1 protein-coding fibroblast growth factor receptor-like 1 We found that miR-210 was highly expressed in hypoxia, which inhibited proliferation by inducing cell cycle arrest in G1/G0 as well as apoptosis. We further identified that miR-210 targeted fibroblast growth factor receptor-like 1 (FGFRL1). Down regulation of FGFRL1 decreased cell proliferation by promoting proportion of cells in G1/G0 phase and decreasing in S and G2/M phases. Moreover, overexpression of FGFRL1 effectively released the miR-210-induced suppression of SCC10A cell proliferation. Expression of miR-210 repressed tumor xenograft growth in vivo as well. Together, our findings reveal a new mechanism of adaptation to hypoxia that miR-210 inhibits the proliferation via inducing cell cycle arrest and apoptosis by the targeting of FGFRL1. 1364 miR-210 hsa-miR-210-5p,hsa-miR-210-3p MIMAT0000267,MIMAT0026475 miRNA HIF1A apoptosis Homo sapiens chondrocytes 24790587 9606 3091 HIF-1A|HIF-1alpha|HIF1|HIF1-ALPHA|MOP1|PASD8|bHLHe78 HGNC:4910|MIM:603348|Ensembl:ENSG00000100644|HPRD:04517|Vega:OTTHUMG00000140344 14 14q23.2 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) HIF-1 ¦Á had pivotal effects on downregulation of miR-210 decreasing viability and inducing apoptosis in hypoxic chondrocytes. 1365 miR-210 hsa-miR-210-5p,hsa-miR-210-3p MIMAT0000267,MIMAT0026475 miRNA HIF1A apoptosis Homo sapiens colon cancer cell 25385144 9606 3091 HIF-1A|HIF-1alpha|HIF1|HIF1-ALPHA|MOP1|PASD8|bHLHe78 HGNC:4910|MIM:603348|Ensembl:ENSG00000100644|HPRD:04517|Vega:OTTHUMG00000140344 14 14q23.2 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) Hypoxia-induced autophagy reduces radiosensitivity by the HIF-1¦Á/miR-210/Bcl-2 pathway in colon cancer cells.The inhibition of HIF-1¦Á decreased miR-210 expression and autophagy. Silencing of miR-210 upregulated Bcl-2 expression and reduced the survival fraction of colon cancer cells after radiation treatment. 1366 miR-210 hsa-miR-210-5p,hsa-miR-210-3p MIMAT0000267,MIMAT0026475 miRNA PTPN1 apoptosis down Homo sapiens cardiomyocytic cell 25016614 9606 5770 PTP1B HGNC:9642|MIM:176885|Ensembl:ENSG00000196396|HPRD:01477|Vega:OTTHUMG00000032729 20 20q13.1-q13.2 protein tyrosine phosphatase, non-receptor type 1 protein-coding protein tyrosine phosphatase, non-receptor type 1 MiR-210 down-regulated its known targets, ephrin A3 and PTP1b, inhibiting apoptosis in cardiomyocytic cells. 1367 miR-210 hsa-miR-210-5p,hsa-miR-210-3p MIMAT0000267,MIMAT0026475 miRNA SIN3A apoptosis down Homo sapiens glioma cell 25481483 9606 25942 - HGNC:19353|MIM:607776|Ensembl:ENSG00000169375|HPRD:09690|Vega:OTTHUMG00000142834 15 15q24.2 SIN3 transcription regulator family member A protein-coding SIN3 transcription regulator family member A miR-210 up-regulation inhibits proliferation and induces apoptosis in glioma cells by targeting SIN3A. Aberrantly expressed miR-210 regulates human U251 glioma cells apoptosis and proliferation partly through directly down-regulating SIN3A protein expression. This might offer a new potential therapeutic stratagem for glioma. 1368 miR-210 hsa-miR-210-5p,hsa-miR-210-3p MIMAT0000267,MIMAT0026475 miRNA STAT3 apoptosis up Homo sapiens endometriotic cyst stromal cell 25516558 9606 6774 APRF|HIES HGNC:11364|MIM:102582|Ensembl:ENSG00000168610|HPRD:00026|Vega:OTTHUMG00000150645 17 17q21.31 signal transducer and activator of transcription 3 (acute-phase response factor) protein-coding signal transducer and activator of transcription 3 (acute-phase response factor) Up-regulated miR-210 expression in ECSCs is involved in their proliferation, resistance to apoptosis and angiogenesis through signal transducer and activator of transcription (STAT) 3. 1369 miR-210 hsa-miR-210-5p,hsa-miR-210-3p MIMAT0000267,MIMAT0026475 miRNA TNF apoptosis Homo sapiens mesenchymal stem cell 25620256 9606 7124 DIF|TNF-alpha|TNFA|TNFSF2 HGNC:11892|MIM:191160|Ensembl:ENSG00000232810|HPRD:01855|Vega:OTTHUMG00000031194 6 6p21.3 tumor necrosis factor protein-coding tumor necrosis factor HCC Cells.MicroRNA-210 mediates the protective effect of rosuvastatin on human mesenchymal stem cells apoptosis induced by tumor necrosis factor-¦Á. 1370 miR-210 hsa-miR-210-3p,hsa-miR-210-5p MIMAT0000267,MIMAT0026475 miRNA apoptosis Homo sapiens HeLa cells 15741182 9606 We also identified miRNA that when inhibited increased the level of apoptosis (miR-1d, 7, 148, 204, 210, 216 and 296) and one miRNA that decreased apoptosis (miR-214) in HeLa cells. 1371 miR-210 hsa-miR-210-5p,hsa-miR-210-3p MIMAT0000267,MIMAT0026475 miRNA apoptosis Homo sapiens UT-7 cell 18492109 9606 A human miRNA microarray was used to analyze miRNA expression in the erythropoietin-dependent cell line UT-7/EPO compared to other factor-dependent UT-7 cell lines. Among 324 human miRNAs, MIRN188, MIRN362 and MIRN210 levels were significantly elevated in UT-7/EPO cells, and stimulation with EPO in UT-7 cells increased the level of these three miRNAs. Notably, knockdown of MIRN210 in UT-7/EPO cells led to apoptosis. 1372 miR-212 hsa-miR-212-3p,hsa-miR-212-5p MIMAT0000269,MIMAT0022695 miRNA EP300 apoptosis Homo sapiens temporal cortical areas and CA1 hippocampal neurons 23585551 9606 2033 KAT3B|RSTS2|p300 HGNC:3373|MIM:602700|Ensembl:ENSG00000100393|HPRD:04078|Vega:OTTHUMG00000150937 22 22q13.2 E1A binding protein p300 protein-coding E1A binding protein p300 we demonstrate that miR-132/212 controls cell survival by direct regulation of PTEN, FOXO3a and P300, which are all key elements of AKT signaling pathway. Silencing of these three target genes by RNAi abrogates apoptosis caused by the miR-132/212 inhibition. 1373 miR-212 hsa-miR-212-3p,hsa-miR-212-5p MIMAT0000269,MIMAT0022695 miRNA FOXO3 apoptosis Homo sapiens temporal cortical areas and CA1 hippocampal neurons 23585551 9606 2309 AF6q21|FKHRL1|FKHRL1P2|FOXO2|FOXO3A HGNC:3821|MIM:602681|Ensembl:ENSG00000118689|HPRD:04061|Vega:OTTHUMG00000015327 6 6q21 forkhead box O3 protein-coding forkhead box O3 we demonstrate that miR-132/212 controls cell survival by direct regulation of PTEN, FOXO3a and P300, which are all key elements of AKT signaling pathway. Silencing of these three target genes by RNAi abrogates apoptosis caused by the miR-132/212 inhibition. 1374 miR-212 hsa-miR-212-5p,hsa-miR-212-3p MIMAT0022695,MIMAT0000269 miRNA PEA15 apoptosis down Homo sapiens non-small cell lung cancer cells 20388802 9606 8682 HMAT1|HUMMAT1H|MAT1|MAT1H|PEA-15|PED HGNC:8822|MIM:603434|Ensembl:ENSG00000162734|HPRD:04579|Vega:OTTHUMG00000031605 1 1q21.1 phosphoprotein enriched in astrocytes 15 protein-coding phosphoprotein enriched in astrocytes 15 MiR-212 increases tumor necrosis factor-related apoptosis-inducing ligand sensitivity in non-small cell lung cancer by targeting the antiapoptotic protein PED. 1375 miR-212 hsa-miR-212-3p,hsa-miR-212-5p MIMAT0000269,MIMAT0022695 miRNA PTEN apoptosis Homo sapiens temporal cortical areas and CA1 hippocampal neurons 23585551 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog we demonstrate that miR-132/212 controls cell survival by direct regulation of PTEN, FOXO3a and P300, which are all key elements of AKT signaling pathway. Silencing of these three target genes by RNAi abrogates apoptosis caused by the miR-132/212 inhibition. 1376 miR-214 hsa-miR-214-3p,hsa-miR-214-5p MIMAT0000271,MIMAT0004564 miRNA BCL2L11 apoptosis up Homo sapiens H9c2 cell 25593579 9606 10018 BAM|BIM|BOD HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 2 2q13 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) Transfection of miR-214 mimic showed protective effects on OGD-induced injury to H9c2 cells by reducing apoptosis, decreasing LDH and CK activities, rescuing the OGD-induced Ca(2+) and down-regulating elevated protein levels of NCX1, BIM, CaMKII¦Ä and CypD. 1377 miR-214 hsa-miR-214-3p,hsa-miR-214-5p MIMAT0000271,MIMAT0004564 miRNA BCL2L2 apoptosis down Homo sapiens cervical cancer HeLa and C-33A cell 23337879 9606 599 BCL-W|BCL2-L-2|BCLW|PPP1R51 HGNC:995|MIM:601931|Ensembl:ENSG00000129473|HPRD:03569|Vega:OTTHUMG00000028738 14 14q11.2-q12 BCL2-like 2 protein-coding BCL2-like 2 Here we demonstrate that ectopic expression of miR-214 reduces cell survival, induces apoptosis and enhances sensitivity to cisplatin through directly inhibiting Bcl2l2 expression in cervical cancer HeLa and C-33A cells. 1378 miR-214 hsa-miR-214-3p,hsa-miR-214-5p MIMAT0000271,MIMAT0004564 miRNA CAMK2A apoptosis up Homo sapiens H9c2 cell 25593579 9606 815 CAMKA HGNC:1460|MIM:114078|Ensembl:ENSG00000070808|HPRD:06532|Vega:OTTHUMG00000134281 5 5q32 calcium/calmodulin-dependent protein kinase II alpha protein-coding calcium/calmodulin-dependent protein kinase II alpha Transfection of miR-214 mimic showed protective effects on OGD-induced injury to H9c2 cells by reducing apoptosis, decreasing LDH and CK activities, rescuing the OGD-induced Ca(2+) and down-regulating elevated protein levels of NCX1, BIM, CaMKII¦Ä and CypD. 1379 miR-214 hsa-miR-214-3p,hsa-miR-214-5p MIMAT0000271,MIMAT0004564 miRNA CMPK1 apoptosis Homo sapiens H9c2 cell 25593579 9606 51727 CK|CMK|CMPK|UMK|UMP-CMPK|UMPK HGNC:18170|MIM:191710|Ensembl:ENSG00000162368|HPRD:18258|Vega:OTTHUMG00000007849 1 1p32 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic protein-coding cytidine monophosphate (UMP-CMP) kinase 1, cytosolic Transfection of miR-214 mimic showed protective effects on OGD-induced injury to H9c2 cells by reducing apoptosis, decreasing LDH and CK activities, rescuing the OGD-induced Ca(2+) and down-regulating elevated protein levels of NCX1, BIM, CaMKII¦Ä and CypD. 1380 miR-214 hsa-miR-214-3p,hsa-miR-214-5p MIMAT0000271,MIMAT0004564 miRNA HDGF apoptosis down Homo sapiens human hepatocellular carcinoma cells 22613005 9606 3068 HMG1L2 HGNC:4856|MIM:600339|Ensembl:ENSG00000143321|HPRD:02079|Vega:OTTHUMG00000041295 1 1q23.1 hepatoma-derived growth factor protein-coding hepatoma-derived growth factor The genes downregulated by ectopic expression of miR-214 were involved in the regulation of apoptosis, cell cycle, and angiogenesis. Downregulation of miR-214 contributes to the unusual hypervascularity of HCC via activation of the HDGF paracrine pathway for tumor angiogenesis. 1381 miR-214 hsa-miR-214-3p,hsa-miR-214-5p MIMAT0000271,MIMAT0004564 miRNA LDHA apoptosis Homo sapiens H9c2 cell 25593579 9606 3939 GSD11|HEL-S-133P|LDH1|LDHM HGNC:6535|MIM:150000|Ensembl:ENSG00000134333|HPRD:01025|Vega:OTTHUMG00000167721 11 11p15.4 lactate dehydrogenase A protein-coding lactate dehydrogenase A Transfection of miR-214 mimic showed protective effects on OGD-induced injury to H9c2 cells by reducing apoptosis, decreasing LDH and CK activities, rescuing the OGD-induced Ca(2+) and down-regulating elevated protein levels of NCX1, BIM, CaMKII¦Ä and CypD. 1382 miR-214 hsa-miR-214-3p,hsa-miR-214-5p MIMAT0000271,MIMAT0004564 miRNA PDRG1 apoptosis down Homo sapiens bladder cancer cell 25706919 9606 81572 C20orf126|PDRG HGNC:16119|MIM:610789|Ensembl:ENSG00000088356|HPRD:17833|Vega:OTTHUMG00000032196 20 20q11.21 p53 and DNA-damage regulated 1 protein-coding p53 and DNA-damage regulated 1 Restoration of miR-214 expression in bladder cancer cell lines inhibited cell proliferation, migration, invasion and markedly promoted apoptosis. Dual-luciferase reporter assay recognized PDRG1 as direct downstream target gene of miR-214 1383 miR-214 hsa-miR-214-3p,hsa-miR-214-5p MIMAT0000271,MIMAT0004564 miRNA PPID apoptosis down Homo sapiens H9c2 cell 25593579 9606 5481 CYP-40|CYPD HGNC:9257|MIM:601753|Ensembl:ENSG00000171497|HPRD:11875|Vega:OTTHUMG00000161927 4 4q31.3 peptidylprolyl isomerase D protein-coding peptidylprolyl isomerase D Transfection of miR-214 mimic showed protective effects on OGD-induced injury to H9c2 cells by reducing apoptosis, decreasing LDH and CK activities, rescuing the OGD-induced Ca(2+) and down-regulating elevated protein levels of NCX1, BIM, CaMKII¦Ä and CypD. 1384 miR-214 hsa-miR-214-3p,hsa-miR-214-5p MIMAT0000271,MIMAT0004564 miRNA PSMD10 apoptosis down Homo sapiens myeloma 23100276 9606 5716 dJ889N15.2|p28|p28(GANK) HGNC:9555|MIM:300880|Ensembl:ENSG00000101843|HPRD:04594|Vega:OTTHUMG00000022177 X Xq22.3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 protein-coding proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 Ectopic expression of miR-214 reduced cell growth and induced apoptosis of myeloma cells.miR-214 directly down-regulated the expression of PSMD10, which encodes the oncoprotein gankyrin, and ASF1B, a histone chaperone required for DNA replication, by binding to their 3'-untranslated regions. 1385 miR-214 hsa-miR-214-5p,hsa-miR-214-3p MIMAT0004564,MIMAT0000271 miRNA PTEN apoptosis down Homo sapiens ovarian cancer cells 18199536 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog MMAC1 phosphatase and ten MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN. 1386 miR-214 hsa-miR-214-5p,hsa-miR-214-3p MIMAT0004564,MIMAT0000271 miRNA PTEN apoptosis down Homo sapiens monocytes 21228352 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog Overexpression of pre-miR-214 led to impaired PTEN expression and delayed apoptosis of THP-1 cells, whereas knockdown of miR-214 level largely abolished AGE-induced cell survival. 1387 miR-214 hsa-miR-214-3p,hsa-miR-214-5p MIMAT0000271 ,MIMAT0004564 miRNA PTEN apoptosis down Homo sapiens 22929890 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog Altogether, these results show that downregulation of miRNA-214 leads to upregulation of PTEN, which subsequently reduces Akt phosphorylation. 1388 miR-214 hsa-miR-214-3p,hsa-miR-214-5p MIMAT0000271,MIMAT0004564 miRNA PTEN apoptosis Homo sapiens osteosarcoma cell 25310480 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog Overexpression of miR-214 in Saos?2 cells induced cell proliferation, while inhibition of miR-214 promoted Saos?2 cell apoptosis in vitro. Furthermore, ectopic expression of miR-214 markedly promoted osteosarcoma development in a subcutaneous xenotransplantation model in BALB/c athymic nude mice. The role of miR-214 in osteocarcinogenesis was further investigated and phosphatase and tensin homolog (PTEN) was determined to be a direct target of miR-214 in Saos?2 cells. The proliferation?promoting effect of PTEN knockdown was similar to that of miR-214 overexpression. 1389 miR-214 hsa-miR-214-3p,hsa-miR-214-5p MIMAT0000271,MIMAT0004564 miRNA SLC8A1 apoptosis down Homo sapiens H9c2 cell 25593579 9606 6546 NCX1 HGNC:11068|MIM:182305|Ensembl:ENSG00000183023|HPRD:01659 2 2p22.1 solute carrier family 8 (sodium/calcium exchanger), member 1 protein-coding solute carrier family 8 (sodium/calcium exchanger), member 1 Transfection of miR-214 mimic showed protective effects on OGD-induced injury to H9c2 cells by reducing apoptosis, decreasing LDH and CK activities, rescuing the OGD-induced Ca(2+) and down-regulating elevated protein levels of NCX1, BIM, CaMKII¦Ä and CypD. 1390 miR-214 hsa-miR-214-3p,hsa-miR-214-5p MIMAT0000271,MIMAT0004564 miRNA apoptosis Homo sapiens HeLa cells 15741182 9606 We also identified miRNA that when inhibited increased the level of apoptosis (miR-1d, 7, 148, 204, 210, 216 and 296) and one miRNA that decreased apoptosis (miR-214) in HeLa cells. 1391 miR-215 hsa-miR-192-5p,hsa-miR-192-3p MIMAT0000222,MIMAT0004543 miRNA IL17A apoptosis down Homo sapiens myeloma 25489847 9606 3605 CTLA8|IL-17|IL-17A|IL17 HGNC:5981|MIM:603149|Ensembl:ENSG00000112115|HPRD:04396|Vega:OTTHUMG00000014840 6 6p12 interleukin 17A protein-coding interleukin 17A IL-17 significantly induced cell proliferation, inhibited cellular apoptosis, repressed cell adhesion to fibronectin and collagen I, Further experiments showed that IL-17 activated the oncogenic p65 transcription factor, which directly repressed the miR-192 gene via binding to the miR-192 promoter. Loss of miR-192 in MM cells can mimic the effects of IL-17, and was required for the above oncogenic effects of IL-17 on MM. Furthermore, we found that miR-192, and its homologous miR-215 directly targeted the 3'-untranslated regions of IL-17Rs, including IL-17RA and RE mRNA. By examining bone marrow specimens derived from MM patients, a negative correlation between miR-192 expression and IL-17 or IL-17RA expression was observed. 1392 miR-215 hsa-miR-192-5p,hsa-miR-192-3p MIMAT0000222,MIMAT0004543 miRNA IL17RA apoptosis down Homo sapiens myeloma 25489847 9606 23765 CANDF5|CD217|CDw217|IL-17RA|IL17R|hIL-17R HGNC:5985|MIM:605461|Ensembl:ENSG00000177663|HPRD:10399|Vega:OTTHUMG00000150026 22 22q11.1 interleukin 17 receptor A protein-coding interleukin 17 receptor A IL-17 significantly induced cell proliferation, inhibited cellular apoptosis, repressed cell adhesion to fibronectin and collagen I, Further experiments showed that IL-17 activated the oncogenic p65 transcription factor, which directly repressed the miR-192 gene via binding to the miR-192 promoter. Loss of miR-192 in MM cells can mimic the effects of IL-17, and was required for the above oncogenic effects of IL-17 on MM. Furthermore, we found that miR-192, and its homologous miR-215 directly targeted the 3'-untranslated regions of IL-17Rs, including IL-17RA and RE mRNA. By examining bone marrow specimens derived from MM patients, a negative correlation between miR-192 expression and IL-17 or IL-17RA expression was observed. 1393 miR-215 hsa-miR-192-5p,hsa-miR-192-3p MIMAT0000222,MIMAT0004543 miRNA XIAP apoptosis down Homo sapiens non-small cell lung cancer cell 25444916 9606 331 API3|BIRC4|IAP-3|ILP1|MIHA|XLP2|hIAP-3|hIAP3 HGNC:592|MIM:300079|Ensembl:ENSG00000101966|HPRD:02094|Vega:OTTHUMG00000022336 X Xq25 X-linked inhibitor of apoptosis protein-coding X-linked inhibitor of apoptosis Taken together, this study highlights that the proapoptotic effects of curcumin depend on miR-192-5p/215 induction and the p53-miR-192-5p/215-XIAP pathway is an important therapeutic target for non-small cell lung cancer. 1394 miR-215 hsa-miR-192-5p,hsa-miR-192-3p MIMAT0000222,MIMAT0004543 miRNA apoptosis Homo sapiens colon cancer cells 22469014 9606 protein coding In vitro analyses showed that ectopic expression of miR-215 decreases viability and migration, increases apoptosis and promotes cell cycle arrest in DLD-1 and HCT-116 colon cancer cell lines. 1395 miR-216 hsa-miR-216a-5p,hsa-miR-216a-3p,hsa-miR-216b-5p,hsa-miR-216b-5p MIMAT0000273,MIMAT0022844,MIMAT0004959,MIMAT0026721 miRNA apoptosis Homo sapiens HeLa cells 15741182 9606 We also identified miRNA that when inhibited increased the level of apoptosis (miR-1d, 7, 148, 204, 210, 216 and 296) and one miRNA that decreased apoptosis (miR-214) in HeLa cells. 1396 miR-216a hsa-miR-216a-5p,hsa-miR-216a-3p MIMAT0000273,MIMAT0022844 miRNA BIRC5 apoptosis down Homo sapiens pancreatic cancer cell 25220761 9606 332 API4|EPR-1 HGNC:593|MIM:603352|Ensembl:ENSG00000089685|HPRD:04520|Vega:OTTHUMG00000177505 17 17q25 baculoviral IAP repeat containing 5 protein-coding baculoviral IAP repeat containing 5 Treatment of pancreatic cancer cells with miR-216a significantly inhibited cell growth and promoted cell apoptosis. In addition, the downstream genes of JAK2/STAT3, survivin and X-linked inhibitor of apoptosis protein, which are anti?apoptotic genes, were also decreased by miR-216a. 1397 miR-216a hsa-miR-216a-5p,hsa-miR-216a-3p MIMAT0000273,MIMAT0022844 miRNA EIF4B apoptosis Homo sapiens non-small-cell lung cancercell 24958806 9606 1975 EIF-4B|PRO1843 HGNC:3285|MIM:603928|Ensembl:ENSG00000063046|HPRD:04892|Vega:OTTHUMG00000169570 12 12q13.13 eukaryotic translation initiation factor 4B protein-coding eukaryotic translation initiation factor 4B Our data also show that overexpression of miR216a suppresses NSCLC cell growth and metastasis, and enhances cisplatin-induced cell growth inhibition and apoptosis. In contrast, inhibition of miR216a stimulates NSCLC cell growth and metastasis, and suppresses cisplatin-induced cell growth inhibition and apoptosis. Furthermore, we demonstrate that miR216a exerts its role by directly targeting eIF4B and ZEB1. 1398 miR-216a hsa-miR-216a-5p,hsa-miR-216a-3p MIMAT0000273,MIMAT0022844 miRNA JAK2 apoptosis down Homo sapiens pancreatic cancer cell 25220761 9606 3717 JTK10|THCYT3 HGNC:6192|MIM:147796|Ensembl:ENSG00000096968|HPRD:00993|Vega:OTTHUMG00000019490 9 9p24 Janus kinase 2 protein-coding Janus kinase 2 Treatment of pancreatic cancer cells with miR-216a significantly inhibited cell growth and promoted cell apoptosis. In addition, the downstream genes of JAK2/STAT3, survivin and X-linked inhibitor of apoptosis protein, which are anti?apoptotic genes, were also decreased by miR-216a. 1399 miR-216a hsa-miR-216a-5p,hsa-miR-216a-3p MIMAT0000273,MIMAT0022844 miRNA STAT3 apoptosis down Homo sapiens pancreatic cancer cell 25220761 9606 6774 APRF|HIES HGNC:11364|MIM:102582|Ensembl:ENSG00000168610|HPRD:00026|Vega:OTTHUMG00000150645 17 17q21.31 signal transducer and activator of transcription 3 (acute-phase response factor) protein-coding signal transducer and activator of transcription 3 (acute-phase response factor) Treatment of pancreatic cancer cells with miR-216a significantly inhibited cell growth and promoted cell apoptosis. In addition, the downstream genes of JAK2/STAT3, survivin and X-linked inhibitor of apoptosis protein, which are anti?apoptotic genes, were also decreased by miR-216a. 1400 miR-216a hsa-miR-216a-5p,hsa-miR-216a-3p MIMAT0000273,MIMAT0022844 miRNA XIAP apoptosis down Homo sapiens pancreatic cancer cell 25220761 9606 331 API3|BIRC4|IAP-3|ILP1|MIHA|XLP2|hIAP-3|hIAP3 HGNC:592|MIM:300079|Ensembl:ENSG00000101966|HPRD:02094|Vega:OTTHUMG00000022336 X Xq25 X-linked inhibitor of apoptosis protein-coding X-linked inhibitor of apoptosis Treatment of pancreatic cancer cells with miR-216a significantly inhibited cell growth and promoted cell apoptosis. In addition, the downstream genes of JAK2/STAT3, survivin and X-linked inhibitor of apoptosis protein, which are anti?apoptotic genes, were also decreased by miR-216a. 1401 miR-216a hsa-miR-216a-5p,hsa-miR-216a-3p MIMAT0000273,MIMAT0022844 miRNA ZEB1 apoptosis Homo sapiens non-small-cell lung cancercell 24958806 9606 6935 AREB6|BZP|DELTAEF1|FECD6|NIL2A|PPCD3|TCF8|ZFHEP|ZFHX1A HGNC:11642|MIM:189909|Ensembl:ENSG00000148516|HPRD:01798|Vega:OTTHUMG00000017907 10 10p11.2 zinc finger E-box binding homeobox 1 protein-coding zinc finger E-box binding homeobox 1 Our data also show that overexpression of miR216a suppresses NSCLC cell growth and metastasis, and enhances cisplatin-induced cell growth inhibition and apoptosis. In contrast, inhibition of miR216a stimulates NSCLC cell growth and metastasis, and suppresses cisplatin-induced cell growth inhibition and apoptosis. Furthermore, we demonstrate that miR216a exerts its role by directly targeting eIF4B and ZEB1. 1402 miR-216b hsa-miR-216b-5p,hsa-miR-216b-5p MIMAT0004959,MIMAT0026721 miRNA P2RX7 apoptosis down Homo sapiens breast cancer cell 25078617 9606 5027 P2X7 HGNC:8537|MIM:602566|Ensembl:ENSG00000089041|HPRD:03977 12 12q24 purinergic receptor P2X, ligand-gated ion channel, 7 protein-coding purinergic receptor P2X, ligand-gated ion channel, 7 Ectopic expression of miR-216b mimics leads to inhibited cell growth and apoptosis, while blocking expression of the miR-216b results in increased cell proliferation. Furthermore, our findings demonstrate that knockdown of P2X7R promotes apoptosis in breast cancer cells through down-regulating Bcl-2 and increasing the cleavage caspase-3 protein level. Finally, we confirmed that down-regulation of miR-216b in breast cancer is inversely associated with P2X7R expression level. 1403 miR-217 hsa-miR-217 MIMAT0000274 miRNA KRAS apoptosis Homo sapiens lung cancer 25234467 9606 3845 C-K-RAS|CFC2|K-RAS2A|K-RAS2B|K-RAS4A|K-RAS4B|KI-RAS|KRAS1|KRAS2|NS|NS3|RASK2 HGNC:6407|MIM:190070|Ensembl:ENSG00000133703|HPRD:01817|Vega:OTTHUMG00000171193 12 12p12.1 Kirsten rat sarcoma viral oncogene homolog protein-coding Kirsten rat sarcoma viral oncogene homolog The effects of miR-217 overexpression on the proliferation, apoptosis, migration and invasion of SPC-A-1 and A549 cells were investigated. The target gene of miR-217 was predicted by Targetscan online software, screened by dual luciferase reporter gene assay and demonstrated by Western blot. Finally, the effects of miR-217 up-regulation on the sensitivity of A549 cells to cisplatin were determined. The expression of miR-217 was significantly lower in lung cancer tissues than in noncancerous tissues (p < 0.001). The overexpression of miR-217 significantly inhibited the proliferation, migration and invasion as well as promoted the apoptosis of lung cancer cells by targeting KRAS. The up-regulation of miR-217 enhanced the sensitivity of SPC-A-1 and A549 cells to cisplatin. In conclusion, miR-217 suppresses tumour development in lung cancer by targeting KRAS and enhances cell sensitivity to cisplatin. Our results encourage researchers to use cisplatin in combination with miR-217 to treat lung cancer. 1404 miR-218 hsa-miR-218-5p,hsa-miR-218-1-3p,hsa-miR-218-2-3p MIMAT0000275,MIMAT0004565,MIMAT0004566 miRNA AKT1 apoptosis Homo sapiens GIST cell 24706111 9606 207 AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA HGNC:391|MIM:164730|Ensembl:ENSG00000142208|HPRD:01261|Vega:OTTHUMG00000170795 14 14q32.32 v-akt murine thymoma viral oncogene homolog 1 protein-coding v-akt murine thymoma viral oncogene homolog 1 The expression of miR-218 is down-regulated in an imatinib mesylate-resistant GIST cell line (GIST430), whereas miR-218 over-expression can improve the sensitivity of GIST cells to imatinib mesylate, with PI3K/AKT signaling pathway possibly involved in the mechanism. 1405 miR-218 hsa-miR-218-5p,hsa-miR-218-1-3p,hsa-miR-218-2-3p MIMAT0000275,MIMAT0004565,MIMAT0004566 miRNA BMI1 apoptosis down Homo sapiens colon cancer 23255074 9606 648 FLVI2/BMI1|PCGF4|RNF51 HGNC:1066|MIM:164831|Ensembl:ENSG00000168283|HPRD:01277|Vega:OTTHUMG00000017807 10 10p11.23 BMI1 proto-oncogene, polycomb ring finger protein-coding BMI1 proto-oncogene, polycomb ring finger MicroRNA-218 inhibits cell cycle progression and promotes apoptosis in colon cancer by downregulating BMI1 polycomb ring finger oncogene. 1406 miR-218 hsa-miR-218-5p,hsa-miR-218-1-3p,hsa-miR-218-2-3p MIMAT0000275,MIMAT0004565,MIMAT0004566 miRNA BMI1 apoptosis down Homo sapiens epatocellular carcinoma (HCC) cell 23996750 9606 648 FLVI2/BMI1|PCGF4|RNF51 HGNC:1066|MIM:164831|Ensembl:ENSG00000168283|HPRD:01277|Vega:OTTHUMG00000017807 10 10p11.23 BMI1 proto-oncogene, polycomb ring finger protein-coding BMI1 proto-oncogene, polycomb ring finger Ectopic expression of miR-218 in HepG2 cells resulted in suppressed cell proliferation and enhanced cell apoptosis as well as the down-regulation of Bmi-1 and CDK6 mRNA and protein expressions (P<0.05). 1407 miR-218 hsa-miR-218-5p,hsa-miR-218-1-3p,hsa-miR-218-2-3p MIMAT0000275,MIMAT0004565,MIMAT0004566 miRNA BRCA1 apoptosis down Homo sapiens breast cancer cell 25394901 9606 672 BRCAI|BRCC1|BROVCA1|IRIS|PNCA4|PPP1R53|PSCP|RNF53 HGNC:1100|MIM:113705|Ensembl:ENSG00000012048|HPRD:00218|Vega:OTTHUMG00000157426 17 17q21 breast cancer 1, early onset protein-coding breast cancer 1, early onset In vivo assay also demonstrated that restoring miR-218 expression in MCF-7/DDP cell line could sensitize cells against cisplatin, thereby increasing cisplatin-mediated tumor cell apoptosis and reducing DNA repair. Kaplan-Meier survival analysis indicated that patients with breast cancer display high levels of miR-218 and low levels of BRCA1 expression; these patients may gain the greatest benefits in terms of increased survival when treated with cisplatin. All of these results indicated that miR-218 has a significant function in the development of cisplatin resistance in breast cancer. Restoring miR-218 expression may constitute a novel therapeutic approach by which to increase cisplatin sensitivity in breast cancer. 1408 miR-218 hsa-miR-218-5p,hsa-miR-218-1-3p,hsa-miR-218-2-3p MIMAT0000275,MIMAT0004565,MIMAT0004566 miRNA CDK6 apoptosis Homo sapiens glioma cell 22088371 9606 1021 PLSTIRE HGNC:1777|MIM:603368|Ensembl:ENSG00000105810|HPRD:04533|Vega:OTTHUMG00000131697 7 7q21-q22 cyclin-dependent kinase 6 protein-coding cyclin-dependent kinase 6 Introducing exogenous miR-218 may effectively down-regulate the CDK6 expression, inhibit cell proliferation and induce apoptosis of malignant giloma cells. These findings imply that miR-218 may serve as a therapeutic agent against malignant glioma. 1409 miR-218 hsa-miR-218-5p,hsa-miR-218-1-3p,hsa-miR-218-2-3p MIMAT0000275,MIMAT0004565,MIMAT0004566 miRNA CDK6 apoptosis down Homo sapiens epatocellular carcinoma (HCC) cell 23996750 9606 1021 PLSTIRE HGNC:1777|MIM:603368|Ensembl:ENSG00000105810|HPRD:04533|Vega:OTTHUMG00000131697 7 7q21-q22 cyclin-dependent kinase 6 protein-coding cyclin-dependent kinase 6 Ectopic expression of miR-218 in HepG2 cells resulted in suppressed cell proliferation and enhanced cell apoptosis as well as the down-regulation of Bmi-1 and CDK6 mRNA and protein expressions (P<0.05). 1410 miR-218 hsa-miR-218-5p,hsa-miR-218-1-3p,hsa-miR-218-2-3p MIMAT0000275,MIMAT0004565,MIMAT0004566 miRNA KIT apoptosis down Homo sapiens gastrointestinal stromal tumor?cell 24375253 9606 3815 C-Kit|CD117|PBT|SCFR HGNC:6342|MIM:164920|Ensembl:ENSG00000157404|HPRD:01287|Vega:OTTHUMG00000128713 4 4q12 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog protein-coding v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog The effect of miR-218 on the proliferation and apoptosis of GIST-T1 cell was analyzed using flow cytometry. Transwell invasion chamber was applied to detect the effect of miR-218 on the invasion of GIST-T1 cells. KIT was identified to be a target gene of miR-218 by the luciferase reporter enzyme system, and the effect of miR-218 on the expression of KIT protein in cells was determined using Western blotting. 1411 miR-218 hsa-miR-218-5p,hsa-miR-218-1-3p,hsa-miR-218-2-3p MIMAT0000275,MIMAT0004565,MIMAT0004566 miRNA PIK3CA apoptosis Homo sapiens GIST cell 24706111 9606 5290 CLOVE|CWS5|MCAP|MCM|MCMTC|PI3K|p110-alpha HGNC:8975|MIM:171834|HPRD:01382 3 3q26.3 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha protein-coding phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha The expression of miR-218 is down-regulated in an imatinib mesylate-resistant GIST cell line (GIST430), whereas miR-218 over-expression can improve the sensitivity of GIST cells to imatinib mesylate, with PI3K/AKT signaling pathway possibly involved in the mechanism. 1412 miR-218 hsa-miR-218-5p,hsa-miR-218-1-3p,hsa-miR-218-2-3p MIMAT0000275,MIMAT0004565,MIMAT0004566 miRNA TPD52 apoptosis Homo sapiens prostate cancer cell 25511701 9606 7163 D52|N8L|PC-1|PrLZ|hD52 HGNC:12005|MIM:604068|Ensembl:ENSG00000076554|HPRD:04963|Vega:OTTHUMG00000164565 8 8q21.13 tumor protein D52 protein-coding tumor protein D52 Based on gain and loss of function analysis, we found miR-218 significantly inhibit cancer cell proliferation by inducing apoptosis. These results strongly suggest that miR-218 plays a tumor suppressor role in PC cells. In addition, our data firstly demonstrated that miR-218 directly regulates oncogenic TPD52 in PC3 cells and the miR-218-TPD52 axis can regulate growth of this prostate cancer cell line. 1413 miR-218 hsa-miR-218-5p,hsa-miR-218-1-3p,hsa-miR-218-2-3p MIMAT0000275,MIMAT0004565,MIMAT0004566 miRNA apoptosis Homo sapiens cervical cancer cells 23443110 9606 Overexpression of miR-218 reduced the proliferation of the human cervical cancer cell line HeLa and induced cell apoptosis through the AKT-mTOR signaling pathway. 1414 miR-218 hsa-miR-218-5p,hsa-miR-218-1-3p,hsa-miR-218-2-3p MIMAT0000275,MIMAT0004565,MIMAT0004566 miRNA apoptosis Homo sapiens cervical cancer cell 24843318 9606 Upregulation of miR-218 significantly enhanced the radiation-induced apoptosis, which was further enhanced by the combination of miR-218 overexpression and radiation In xenograft growth assay, combination of miR-218 overexpression and radiation notably induced cellular apoptosis and suppressed tumor growth. In conclusion, we demonstrated that miR-218 resensitized cervical cancer cells to radiation via promoting cellular apoptosis. Moreover, we proved that miR-218 as a potent predictor of radiosensitivity in cervical cancer, especially for those patients with loss of miR-218. 1415 miR-218 hsa-miR-218-5p,hsa-miR-218-1-3p,hsa-miR-218-2-3p MIMAT0000275,MIMAT0004565,MIMAT0004566 miRNA apoptosis Homo sapiens liver cancer cell 25416134 9606 Traditional Chinese medicine is recently emerged as anti-cancer therapy or adjuvant with reduced side-effects and improved quality of life. In the present study, an active ingredient, 1,6,7-trihydroxyxanthone (THA), derived from Goodyera oblongifolia was found to strongly suppress cell growth and induce apoptosis in liver cancer cells. MicroRNAs are a group of small non-coding RNAs that regulate gene expression at post-transcriptional levels. Our results demonstrated that miR-218 was up-regulated and oncogene Bmi-1 was down-regulated by THA treatment. Further investigation showed that THA-induced-miR-218 up-regulation could lead to activation of tumor suppressor P16(Ink4a) and P14(ARF), the main down-stream targets of Bmi-1. In conclusion, THA might be a potential anti-cancer drug candidate, at least in part, through the activation of miR-218 and suppression of Bmi-1 expression. 1416 miR-218 hsa-miR-218-5p,hsa-miR-218-1-3p,hsa-miR-218-2-3p MIMAT0000275,MIMAT0004565,MIMAT0004566 miRNA apoptosis Homo sapiens osteosarcoma cell 25479631 9606 The low-expression of miR-218 is correlated with the poor clinicopathological features in osteosarcoma. Moreover, miR-218 overexpression reduces cancer cell proliferation and induces apoptosis in Saos-2 cells, suggesting that miR-218 may play a key role in the progression of human osteosarcoma. 1417 miR-219 hsa-miR-219a-5p,hsa-miR-219a-1-3p,hsa-miR-219a-2-3p MIMAT0000276,MIMAT0004567,MIMAT0004675 miRNA apoptosis Homo sapiens breast cancer cells 23813567 9606 Overexpression of miR-219 in MCF-7 breast cancer cells resulted in accentuated expression of apoptosis- and proliferation-related anti-viral immunodulators of the Jak-STAT and NF-°ÙÉÇ pathways. 1418 miR-219 hsa-miR-219a-5p,hsa-miR-219a-1-3p,hsa-miR-219a-2-3p MIMAT0000276,MIMAT0004567,MIMAT0004675 miRNA apoptosis Homo sapiens 25069442 9606 In particular, the miR-219 transfection increased astrocyte viability, growth, and differentiation while decreasing cell necrosis and apoptosis. Thus, microRNA-219 transfection is a valuable strategy in order to confer resistance to astrocytes towards lymphocyte-induced neurotoxici-ty especially in the presence of IFN-alpha, whose levels are typically increased in the cerebrospinal fluid of AGS patients. 1419 miR-219-5p hsa-miR-219a-5p,hsa-miR-219a-1-3p,hsa-miR-219a-2-3p MIMAT0000276,MIMAT0004567,MIMAT0004675 miRNA ESR1 apoptosis down Homo sapiens Papillary thyroid carcinoma cell 25423566 9606 2099 ER|ESR|ESRA|ESTRR|Era|NR3A1 HGNC:3467|MIM:133430|Ensembl:ENSG00000091831|HPRD:00589|Vega:OTTHUMG00000016103 6 6q25.1 estrogen receptor 1 protein-coding estrogen receptor 1 The current study confirmed that miR-219-5p expression was inhibited in PTC tissue samples. There were statistically significant differences in the expression of miR-219-5p with regard to sex, tumor size, and lymph node metastasis in patients with PTC. Forced expression of miR-219-5p suppressed PTC cell proliferation and migration and promoted apoptosis. Further study showed that estrogen receptor (ER) ¦Á was the direct target of miR-219-5p and mediated the effect of miR-219-5p on PTC occurrence. Expression of miR-219-5p was inversely correlated with that of ER¦Á. Importantly, ER¦Á overexpression in PTC cells rescued the inhibitory effect of miR-219-5p on PTC cell proliferation and migration. 1420 miR-219-5p hsa-miR-219a-5p,hsa-miR-219a-1-3p,hsa-miR-219a-2-3p MIMAT0000276,MIMAT0004567,MIMAT0004675 miRNA MT1F apoptosis Homo sapiens 24974767 9606 4494 MT1 HGNC:7398|MIM:156352|Ensembl:ENSG00000198417|HPRD:01127 16 16q13 metallothionein 1F protein-coding metallothionein 1F Network analysis were further conducted on mRNA-miRNA pairs, which revealed that miR-219-5p-MT1F and -TRIB3 pairs by AgNPs are being involved in various cellular processes, such as, oxidative stress, cell cycle and apoptosis. 1421 miR-219-5p hsa-miR-219a-5p,hsa-miR-219a-1-3p,hsa-miR-219a-2-3p MIMAT0000276,MIMAT0004567,MIMAT0004675 miRNA TRIB3 apoptosis Homo sapiens 24974767 9606 57761 C20orf97|NIPK|SINK|SKIP3|TRB3 HGNC:16228|MIM:607898|Ensembl:ENSG00000101255|HPRD:09836|Vega:OTTHUMG00000031627 20 20p13-p12.2 tribbles pseudokinase 3 protein-coding tribbles pseudokinase 3 Network analysis were further conducted on mRNA-miRNA pairs, which revealed that miR-219-5p-MT1F and -TRIB3 pairs by AgNPs are being involved in various cellular processes, such as, oxidative stress, cell cycle and apoptosis. 1422 miR-22 hsa-miR-22-5p,hsa-miR-22-3p MIMAT0004495,MIMAT0000077 miRNA MAPK14 apoptosis down Homo sapiens brain cells 23349832 9606 1432 CSBP|CSBP1|CSBP2|CSPB1|EXIP|Mxi2|PRKM14|PRKM15|RK|SAPK2A|p38|p38ALPHA HGNC:6876|MIM:600289|Ensembl:ENSG00000112062|HPRD:02619|Vega:OTTHUMG00000159806 6 6p21.3-p21.2 mitogen-activated protein kinase 14 protein-coding mitogen-activated protein kinase 14 The mechanisms underlying the effects of miR-22 included a reduction in caspase activation, consistent with miR-22's targeting the pro-apoptotic activities of mitogen-activated protein kinase 14/p38 (MAPK14/p38) and tumor protein p53-inducible nuclear protein 1 (Tp53inp1). These data show that miR-22 has multipartite anti-neurodegenerative activities including the inhibition of apoptosis and the targeting of mRNAs implicated in the etiology of HD. 1423 miR-22 hsa-miR-22-5p,hsa-miR-22-3p MIMAT0004495,MIMAT0000077 miRNA MECOM apoptosis down Homo sapiens ovarian cancer cell 20081105 9606 2122 AML1-EVI-1|EVI1|MDS1|MDS1-EVI1|PRDM3 HGNC:3498|MIM:165215|Ensembl:ENSG00000085276|HPRD:01310|Vega:OTTHUMG00000158596 3 3q26.2 MDS1 and EVI1 complex locus protein-coding MDS1 and EVI1 complex locus Furthermore, overexpression of the putative tumor suppressor mir-22 repressed the EVI1 oncogene, which is known to suppress apoptosis by stimulating phosphatidylinositol 3-kinase/v-akt murine thymoma viral oncogene homolog 1 signaling. 1424 miR-22 hsa-miR-22-5p,hsa-miR-22-3p MIMAT0004495,MIMAT0000077 miRNA PTEN apoptosis down Homo sapiens bronchial epithelial cells 20170724 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog MiR-22 functions as a micro-oncogene that can invert the functionality of PTEN. 1425 miR-22 hsa-miR-22-5p,hsa-miR-22-3p MIMAT0004495,MIMAT0000077 miRNA RAD51 apoptosis up Homo sapiens esophageal squamous cells 23188185 9606 5888 BRCC5|HRAD51|HsRad51|HsT16930|MRMV2|RAD51A|RECA HGNC:9817|MIM:179617|Ensembl:ENSG00000051180|HPRD:01557|Vega:OTTHUMG00000130067 15 15q15.1 RAD51 recombinase protein-coding RAD51 recombinase Increased expression of miRNA-22 sensitized ESCC cells to ¦Ã-ray radiation and promoted the apoptosis of ESCC cells induced by ¦Ã-ray radiation. Increased expression level of miRNA-22 had effects on Rad51 expression after irradiation. 1426 miR-22 hsa-miR-22-5p,hsa-miR-22-3p MIMAT0004495,MIMAT0000077 miRNA TP53INP1 apoptosis down Homo sapiens 23349832 9606 94241 SIP|TP53DINP1|TP53INP1A|TP53INP1B|Teap|p53DINP1 HGNC:18022|MIM:606185|Ensembl:ENSG00000164938|HPRD:09367|Vega:OTTHUMG00000164697 8 8q22 tumor protein p53 inducible nuclear protein 1 protein-coding tumor protein p53 inducible nuclear protein 1 The mechanisms underlying the effects of miR-22 included a reduction in caspase activation, consistent with miR-22's targeting the pro-apoptotic activities of mitogen-activated protein kinase 14/p38 (MAPK14/p38) and tumor protein p53-inducible nuclear protein 1 (Tp53inp1). These data show that miR-22 has multipartite anti-neurodegenerative activities including the inhibition of apoptosis and the targeting of mRNAs implicated in the etiology of HD. 1427 miR-22 hsa-miR-22-5p,hsa-miR-22-3p MIMAT0004495,MIMAT0000077 miRNA apoptosis down Homo sapiens DAOY cell 24576181 9606 347734 SLL|SLC35B2|UGTrel4 HGNC:16872|Ensembl:ENSG00000157593|HPRD:11576|MIM:610788|Vega:OTTHUMG00000014760 6 6p12.1-p11.2 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2 protein coding solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2 Microarray analysis in DAOY cells with forced miR-22 expression showed significant changes in expression profiles, PAPST1 being the most significantly (10 folds) downregulated gene. 1428 miR-221 hsa-miR-221-5p,hsa-miR-221-3p MIMAT0004568,MIMAT0000278 miRNA BAX apoptosis up Homo sapiens bladder cancer cell 25585941 9606 581 BCL2L4 HGNC:959|MIM:600040|Ensembl:ENSG00000087088|HPRD:02498|Vega:OTTHUMG00000160476 19 19q13.3-q13.4 BCL2-associated X protein protein-coding BCL2-associated X protein In this study, miR?221 inhibitor was transfected into bladder cancer cell lines 5637, J82 and T24 to repress the expression of miR?221. As a result, the repression of miR?221 on p53 upregulated modulator of apoptosis (PUMA) was abolished, resulting in increased expression of the pro-apoptotic Bax and reduced expression of the anti-apoptotic Bcl-2, which promotes apoptosis of bladder cancer cells. 1429 miR-221 hsa-miR-221-5p,hsa-miR-221-3p MIMAT0004568,MIMAT0000278 miRNA BBC3 apoptosis down Homo sapiens glioblastoma cells 20813046 9606 27113 JFY-1|JFY1|PUMA HGNC:17868|MIM:605854|Ensembl:ENSG00000105327|HPRD:16165|Vega:OTTHUMG00000183489 19 19q13.3-q13.4 BCL2 binding component 3 protein-coding BCL2 binding component 3 bcl-2-binding component 3 Here we showed that miR-221/222 inhibited cell apoptosis by targeting pro-apoptotic gene PUMA in human glioma cells. Enforced expression of miR-22/222 induced cell survival whereas knockdown of miR-221/222 rendered cells to apoptosis. 1430 miR-221 hsa-miR-221-5p,hsa-miR-221-3p MIMAT0004568,MIMAT0000278 miRNA BBC3 apoptosis Homo sapiens epithelial cancer cell 21042732 9606 27113 JFY-1|JFY1|PUMA HGNC:17868|MIM:605854|Ensembl:ENSG00000105327|HPRD:16165|Vega:OTTHUMG00000183489 19 19q13.3-q13.4 BCL2 binding component 3 protein-coding BCL2 binding component 3 Bioinformatics and luciferase reporter assays showed that miR-221/222 co-modulated the p53 upregulated modulator of apoptosis (PUMA) expression by directly targeting the binding site within the 3'UTR. Together, these findings suggest that PUMA is a direct target of miR-221/222 that functions as an endogenous apoptosis regulator in these epithelial cancers. 1431 miR-221 hsa-miR-221-3p,hsa-miR-221-5p MIMAT0000278,MIMAT0004568 miRNA BCL2 apoptosis down Homo sapiens bladder cancer cell 25585941 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 In this study, miR?221 inhibitor was transfected into bladder cancer cell lines 5637, J82 and T24 to repress the expression of miR?221. As a result, the repression of miR?221 on p53 upregulated modulator of apoptosis (PUMA) was abolished, resulting in increased expression of the pro-apoptotic Bax and reduced expression of the anti-apoptotic Bcl-2, which promotes apoptosis of bladder cancer cells. 1432 miR-221 hsa-miR-221-5p,hsa-miR-221-3p MIMAT0004568,MIMAT0000278 miRNA BCL2 apoptosis down Homo sapiens bladder cancer cell 25585941 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 In this study, miR?221 inhibitor was transfected into bladder cancer cell lines 5637, J82 and T24 to repress the expression of miR?221. As a result, the repression of miR?221 on p53 upregulated modulator of apoptosis (PUMA) was abolished, resulting in increased expression of the pro-apoptotic Bax and reduced expression of the anti-apoptotic Bcl-2, which promotes apoptosis of bladder cancer cells. 1433 miR-221 hsa-miR-221-5p,hsa-miR-221-3p MIMAT0004568,MIMAT0000278 miRNA BMF apoptosis down Homo sapiens hepatocellular carcinoma cells 19671867 9606 90427 - HGNC:24132|MIM:606266|Ensembl:ENSG00000104081|HPRD:05881|Vega:OTTHUMG00000129875 15 15q14 Bcl2 modifying factor protein-coding Bcl2 modifying factor bcl-2-modifying factor The analysis of HCC tissues revealed an inverse correlation between miR-221 and Bmf expression and a direct correlation between Bmf and activated caspase-3, as a marker of apoptosis. 1434 miR-221 hsa-miR-221-3p,hsa-miR-221-5p MIMAT0000278,MIMAT0004568 miRNA CASP3 apoptosis Homo sapiens bladder cancer cell 19767219 9606 836 CPP32|CPP32B|SCA-1 HGNC:1504|MIM:600636|Ensembl:ENSG00000164305|HPRD:02799|Vega:OTTHUMG00000133681 4 4q34 caspase 3, apoptosis-related cysteine peptidase protein-coding caspase 3, apoptosis-related cysteine peptidase Human miRNA-221 was significantly up-regulated in bladder cancer T24 cells and RT4 cells compared to human normal urothelial cells. T24 cell was TRAIL-resistant cell line. MiRNA-221 silencing predisposed T24 cells to undergo apoptosis induced by TRAIL and resulted in an up-modulation of cyclin-dependent kinase inhibitor p27Kip1. MiRNA-221 suppression promoted the activation of caspase 3 induced by TRAIL in T24 cells. 1435 miR-221 hsa-miR-221-5p,hsa-miR-221-3p MIMAT0004568,MIMAT0000278 miRNA CASP3 apoptosis Homo sapiens HepG2 cell 22152314 9606 836 CPP32|CPP32B|SCA-1 HGNC:1504|MIM:600636|Ensembl:ENSG00000164305|HPRD:02799|Vega:OTTHUMG00000133681 4 4q34 caspase 3, apoptosis-related cysteine peptidase protein-coding caspase 3, apoptosis-related cysteine peptidase The result from Apo-ONE homogeneous caspase-3/7 kit was consistent with the above two apoptotic assays, which showed that with miR-221 inhibitors, the activity of caspase-3/7 was significantly enhanced (P is less than to 0.05). 1436 miR-221 hsa-miR-221-5p,hsa-miR-221-3p MIMAT0004568,MIMAT0000278 miRNA CASP3 apoptosis down Homo sapiens 24969479 9606 836 CPP32|CPP32B|SCA-1 HGNC:1504|MIM:600636|Ensembl:ENSG00000164305|HPRD:02799|Vega:OTTHUMG00000133681 4 4q34 caspase 3, apoptosis-related cysteine peptidase protein-coding caspase 3, apoptosis-related cysteine peptidase As a result, we conclude that miR-221 may have a crucial role in repressing the expression of caspase-3 which may contribute to a lower apoptotic rate, thus supporting the selection of more aggressive cancer cells. To our knowledge, this is the first study related to the expression levels of caspase-3 and miR-221 in different cell lines at the same time. We expect that our study might pave the way for better understanding the role of miR-221 in apoptotic regulation of caspase-3. 1437 miR-221 hsa-miR-221-5p,hsa-miR-221-3p MIMAT0004568,MIMAT0000278 miRNA CASP7 apoptosis Homo sapiens HepG2 cell 22152314 9606 840 CASP-7|CMH-1|ICE-LAP3|LICE2|MCH3 HGNC:1508|MIM:601761|Ensembl:ENSG00000165806|HPRD:03457|Vega:OTTHUMG00000019076 10 10q25 caspase 7, apoptosis-related cysteine peptidase protein-coding caspase 7, apoptosis-related cysteine peptidase The result from Apo-ONE homogeneous caspase-3/7 kit was consistent with the above two apoptotic assays, which showed that with miR-221 inhibitors, the activity of caspase-3/7 was significantly enhanced (P is less than to 0.05). 1438 miR-221 hsa-miR-221-5p,hsa-miR-221-3p MIMAT0004568,MIMAT0000278 miRNA CDH1 apoptosis Homo sapiens breast cancer cell 23637992 9606 999 Arc-1|CD324|CDHE|ECAD|LCAM|UVO HGNC:1748|MIM:192090|Ensembl:ENSG00000039068|HPRD:01885|Vega:OTTHUMG00000137561 16 16q22.1 cadherin 1, type 1, E-cadherin (epithelial) protein-coding cadherin 1, type 1, E-cadherin (epithelial) MiR-221 knockdown not only blocked cell cycle progression, induced cell apoptosis, and inhibited cell proliferation in-vitro but it also inhibited in-vivo tumor growth by targeting p27(kip1). Furthermore, miR-221 knockdown inhibited cell migration and invasion by altering E-cadherin expression, and its regulatory transcription factors Snail and Slug in human TNBC cell lines. Therefore, miR-221 functions as an oncogene and is essential in regulating tumorigenesis in TNBCs both in vitro as well as in vivo. 1439 miR-221 hsa-miR-221-5p,hsa-miR-221-3p MIMAT0004568,MIMAT0000278 miRNA CDKN1B apoptosis down Homo sapiens lung cancer cells 18246122 9606 1027 CDKN4|KIP1|MEN1B|MEN4|P27KIP1 HGNC:1785|MIM:600778|Ensembl:ENSG00000111276|HPRD:02867|Vega:OTTHUMG00000149914 12 12p13.1-p12 cyclin-dependent kinase inhibitor 1B (p27, Kip1) protein-coding cyclin-dependent kinase inhibitor 1B (p27, Kip1) cyclin-dependent kinase i MiR-221 and -222 target the 3'-UTR of Kit and p27(kip1) mRNAs, but interfere with TRAIL signaling mainly through p27(kip1). High expression levels of miR-221 and -222 are needed to maintain the TRAIL-resistant phenotype. 1440 miR-221 hsa-miR-221-3p,hsa-miR-221-5p MIMAT0000278,MIMAT0004568 miRNA CDKN1B apoptosis up Homo sapiens bladder cancer cell 19767219 9606 1027 CDKN4|KIP1|MEN1B|MEN4|P27KIP1 HGNC:1785|MIM:600778|Ensembl:ENSG00000111276|HPRD:02867|Vega:OTTHUMG00000149914 12 12p13.1-p12 cyclin-dependent kinase inhibitor 1B (p27, Kip1) protein-coding cyclin-dependent kinase inhibitor 1B (p27, Kip1) Human miRNA-221 was significantly up-regulated in bladder cancer T24 cells and RT4 cells compared to human normal urothelial cells. T24 cell was TRAIL-resistant cell line. MiRNA-221 silencing predisposed T24 cells to undergo apoptosis induced by TRAIL and resulted in an up-modulation of cyclin-dependent kinase inhibitor p27Kip1. MiRNA-221 suppression promoted the activation of caspase 3 induced by TRAIL in T24 cells. 1441 miR-221 hsa-miR-221-5p,hsa-miR-221-3p MIMAT0004568,MIMAT0000278 miRNA CDKN1B apoptosis Homo sapiens HCC cell 20624000 9606 1027 CDKN4|KIP1|MEN1B|MEN4|P27KIP1 HGNC:1785|MIM:600778|Ensembl:ENSG00000111276|HPRD:02867|Vega:OTTHUMG00000149914 12 12p13.1-p12 cyclin-dependent kinase inhibitor 1B (p27, Kip1) protein-coding cyclin-dependent kinase inhibitor 1B (p27, Kip1) We observed that the microRNAs miR-221/222 are associated with apoptosis regulation under ER stress in human hepatocellular carcinoma (HCC) cells. In these cells, ER stress-induced apoptosis is enhanced by miR-221/222 mimics and attenuated by miR-221/222 inhibitors. miR-221/222 promoted-apoptosis under ER stress is associated with p27(Kip1)- and MEK/ERK-mediated cell cycle regulation. 1442 miR-221 hsa-miR-221-3p,hsa-miR-221-5p MIMAT0000278,MIMAT0004568 miRNA CDKN1B apoptosis up Homo sapiens dendritic cells 21355095 9606 1027 CDKN4|KIP1|MEN1B|MEN4|P27KIP1 HGNC:1785|MIM:600778|Ensembl:ENSG00000111276|HPRD:02867|Vega:OTTHUMG00000149914 12 12p13.1-p12 cyclin-dependent kinase inhibitor 1B (p27, Kip1) protein-coding cyclin-dependent kinase inhibitor 1B (p27, Kip1) Among them, decreased miR-221 and increased miR-155 expression correlated with p27(kip1) accumulation in DCs. Silencing of miR-221 or overexpressing of miR-155 in DCs resulted in p27(kip1) protein increase and DC apoptosis. 1443 miR-221 hsa-miR-221-5p,hsa-miR-221-3p MIMAT0004568,MIMAT0000278 miRNA CDKN1B apoptosis Homo sapiens hepatocarcinoma cell 21586237 9606 1027 CDKN4|KIP1|MEN1B|MEN4|P27KIP1 HGNC:1785|MIM:600778|Ensembl:ENSG00000111276|HPRD:02867|Vega:OTTHUMG00000149914 12 12p13.1-p12 cyclin-dependent kinase inhibitor 1B (p27, Kip1) protein-coding cyclin-dependent kinase inhibitor 1B (p27, Kip1) MiR-221/222 were downregulated by endoplasmic reticulum stress in human hepatocellular carcinoma cells, which subsequently protected human hepatocellular carcinoma cells against endoplasmic reticulum stress-induced apoptosis through p27Kip1 regulation. 1444 miR-221 hsa-miR-221-5p,hsa-miR-221-3p MIMAT0004568,MIMAT0000278 miRNA CDKN1C apoptosis down Homo sapiens colorectal carcinoma cells 21278784 9606 1028 BWCR|BWS|KIP2|WBS|p57|p57Kip2 HGNC:1786|MIM:600856|Ensembl:ENSG00000129757|HPRD:02913|Vega:OTTHUMG00000010040 11 11p15.5 cyclin-dependent kinase inhibitor 1C (p57, Kip2) protein-coding cyclin-dependent kinase inhibitor 1C (p57, Kip2) cyclin-dependent kinase i MiR-221 binds to the target site in the 3'-UTR of the CDKN1C/p57 mRNA to inhibit CDKN1C/p57 expression by post-transcriptional gene silencing to promote CRC occurrence and progress. 1445 miR-221 hsa-miR-221-5p,hsa-miR-221-3p MIMAT0004568,MIMAT0000278 miRNA CDKN1C apoptosis down Homo sapiens colorectal carcinoma cells 21538272 9606 1028 BWCR|BWS|KIP2|WBS|p57|p57Kip2 HGNC:1786|MIM:600856|Ensembl:ENSG00000129757|HPRD:02913|Vega:OTTHUMG00000010040 11 11p15.5 cyclin-dependent kinase inhibitor 1C (p57, Kip2) protein-coding cyclin-dependent kinase inhibitor 1C (p57, Kip2) cyclin-dependent kinase i MiR-221-specific inhibitor significantly enhanced CDKN1C/P57 protein expression, inhibited proliferation of CRC cells and induced apoptosis of CRC cells(P<0.01). 1446 miR-221 hsa-miR-221-5p,hsa-miR-221-3p MIMAT0004568,MIMAT0000278 miRNA DIRAS3 apoptosis Homo sapiens prostate cancer cell 21071579 9606 9077 ARHI|NOEY2 HGNC:687|MIM:605193|Ensembl:ENSG00000162595|HPRD:05547|Vega:OTTHUMG00000009544 1 1p31 DIRAS family, GTP-binding RAS-like 3 protein-coding DIRAS family, GTP-binding RAS-like 3 Overexpression of ARHI inhibited cell proliferation, colony formation, invasion, and induced apoptosis. Further studies on a new mechanism of ARHI downregulation showed a significant inverse relationship between ARHI and miR-221 and 222, which were upregulated in prostate cancer cell lines. 1447 miR-221 hsa-miR-221-5p,hsa-miR-221-3p MIMAT0004568,MIMAT0000278 miRNA DIRAS3 apoptosis down Homo sapiens breast cancer cell 23801152 9606 9077 ARHI|NOEY2 HGNC:687|MIM:605193|Ensembl:ENSG00000162595|HPRD:05547|Vega:OTTHUMG00000009544 1 1p31 DIRAS family, GTP-binding RAS-like 3 protein-coding DIRAS family, GTP-binding RAS-like 3 The overexpression of ARHI could inhibit breast cancer cell proliferation and invasion and induce cell apoptosis. This study demonstrated for the first time that the downregulation of ARHI in breast cancer cells could be regulated by miR-221. 1448 miR-221 hsa-miR-221-5p,hsa-miR-221-3p MIMAT0004568,MIMAT0000278 miRNA KIT apoptosis down Homo sapiens lung cancer cells 18246122 9606 3815 C-Kit|CD117|PBT|SCFR HGNC:6342|MIM:164920|Ensembl:ENSG00000157404|HPRD:01287|Vega:OTTHUMG00000128713 4 4q12 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog protein-coding v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog cyclin-dependent kinase i MiR-221 and -222 target the 3'-UTR of Kit and p27(kip1) mRNAs, but interfere with TRAIL signaling mainly through p27(kip1). High expression levels of miR-221 and -222 are needed to maintain the TRAIL-resistant phenotype. 1449 miR-221 hsa-miR-221-5p,hsa-miR-221-3p MIMAT0004568,MIMAT0000278 miRNA MAP2K7 apoptosis Homo sapiens HCC cell 20624000 9606 5609 JNKK2|MAPKK7|MEK|MEK 7|MKK7|PRKMK7|SAPKK-4|SAPKK4 HGNC:6847|MIM:603014|Ensembl:ENSG00000076984|Vega:OTTHUMG00000137368 19 19p13.3-p13.2 mitogen-activated protein kinase kinase 7 protein-coding mitogen-activated protein kinase kinase 7 We observed that the microRNAs miR-221/222 are associated with apoptosis regulation under ER stress in human hepatocellular carcinoma (HCC) cells. In these cells, ER stress-induced apoptosis is enhanced by miR-221/222 mimics and attenuated by miR-221/222 inhibitors. miR-221/222 promoted-apoptosis under ER stress is associated with p27(Kip1)- and MEK/ERK-mediated cell cycle regulation. 1450 miR-221 hsa-miR-221-5p,hsa-miR-221-3p MIMAT0004568,MIMAT0000278 miRNA MAPK1 apoptosis Homo sapiens HCC cell 20624000 9606 5594 ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK HGNC:6871|MIM:176948|Ensembl:ENSG00000100030|HPRD:01496|Vega:OTTHUMG00000030508 22 22q11.21 mitogen-activated protein kinase 1 protein-coding mitogen-activated protein kinase 1 We observed that the microRNAs miR-221/222 are associated with apoptosis regulation under ER stress in human hepatocellular carcinoma (HCC) cells. In these cells, ER stress-induced apoptosis is enhanced by miR-221/222 mimics and attenuated by miR-221/222 inhibitors. miR-221/222 promoted-apoptosis under ER stress is associated with p27(Kip1)- and MEK/ERK-mediated cell cycle regulation. 1451 miR-221 hsa-miR-221-5p,hsa-miR-221-3p MIMAT0004568,MIMAT0000278 miRNA NAIP apoptosis down Homo sapiens neural cell 18759060 9606 4671 BIRC1|NLRB1|psiNAIP HGNC:7634|MIM:600355|Ensembl:ENSG00000249437|Vega:OTTHUMG00000163318 5 5q13.2 NLR family, apoptosis inhibitory protein protein-coding NLR family, apoptosis inhibitory protein We observed selective up-regulation of miRNA-221 and down-regulation of a miRNA-221 messenger RNA target encoding the survivin-1 homolog BIRC1, a neuronal inhibitor of apoptosis protein (NIAP) and marker for neurodegeneration. 1452 miR-221 hsa-miR-221-5p,hsa-miR-221-3p MIMAT0004568,MIMAT0000278 miRNA PTEN apoptosis up Homo sapiens 21481725 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog We identified the PTEN gene as a target of miRNA-221/-222. Furthermore, we found that knocking down miRNA-221/-222 by antisense oligonucleotides upregulated PTEN expression. Upregulated PTEN expression suppressed AKT activity and increased radiation-induced apoptosis, resulting in enhancement of radiosensitivity in tumor cells. 1453 miR-221 hsa-miR-221-3p,hsa-miR-221-5p MIMAT0000278,MIMAT0004568 miRNA PTEN apoptosis down Homo sapiens osteosarcoma cells 23372675 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog The effects of miR-221 were then assessed by cell viability, cell cycle analysis, apoptosis assay, and cisplatin resistance assay. In both cells, upregulation of miR-221 induced cell survival and cisplatin resistance and reduced cell apoptosis. In addition, knockdown of miR-221 inhibited cell growth and cisplatin resistance and induced cell apoptosis. Potential target genes of miR-221 were predicted using bioinformatics. Moreover, luciferase reporter assay and western blot confirmed that PTEN was a direct target of miR-221. 1454 miR-221 hsa-miR-221-3p,hsa-miR-221-5p MIMAT0000278,MIMAT0004568 miRNA PTEN apoptosis down Homo sapiens breast cancers cell 24286315 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog Here, we found that the oncogenic miRNA, miR-221, inhibited apoptosis, induced trastuzumab resistance and promoted metastasis of HER2-positive breast cancers. The tumor suppressor PTEN was identified as a miR-221 target; overexpression of PTEN abrogated the aforementioned miR-221-induced malignant phenotypes of the cells. 1455 miR-221 hsa-miR-221-5p,hsa-miR-221-3p MIMAT0004568,MIMAT0000278 miRNA SNAI1 apoptosis Homo sapiens breast cancer cell 23637992 9606 6615 SLUGH2|SNA|SNAH|SNAIL|SNAIL1|dJ710H13.1 HGNC:11128|MIM:604238|Ensembl:ENSG00000124216|HPRD:05025|Vega:OTTHUMG00000033048 20 20q13.2 snail family zinc finger 1 protein-coding snail family zinc finger 1 MiR-221 knockdown not only blocked cell cycle progression, induced cell apoptosis, and inhibited cell proliferation in-vitro but it also inhibited in-vivo tumor growth by targeting p27(kip1). Furthermore, miR-221 knockdown inhibited cell migration and invasion by altering E-cadherin expression, and its regulatory transcription factors Snail and Slug in human TNBC cell lines. Therefore, miR-221 functions as an oncogene and is essential in regulating tumorigenesis in TNBCs both in vitro as well as in vivo. 1456 miR-221 hsa-miR-221-3p,hsa-miR-221-5p MIMAT0000278,MIMAT0004568 miRNA SNAI2 apoptosis Homo sapiens breast cancer cell 23637992 9606 6591 SLUG|SLUGH1|SNAIL2|WS2D HGNC:11094|MIM:602150|Ensembl:ENSG00000019549|HPRD:03689|Vega:OTTHUMG00000149912 8 8q11 snail family zinc finger 2 protein-coding snail family zinc finger 2 MiR-221 knockdown not only blocked cell cycle progression, induced cell apoptosis, and inhibited cell proliferation in-vitro but it also inhibited in-vivo tumor growth by targeting p27(kip1). Furthermore, miR-221 knockdown inhibited cell migration and invasion by altering E-cadherin expression, and its regulatory transcription factors Snail and Slug in human TNBC cell lines. Therefore, miR-221 functions as an oncogene and is essential in regulating tumorigenesis in TNBCs both in vitro as well as in vivo. 1457 miR-221 hsa-miR-221-3p,hsa-miR-221-5p MIMAT0000278,MIMAT0004568 miRNA TIMP2 apoptosis down Homo sapiens glioma cell 25731730 9606 7077 CSC-21K|DDC8 HGNC:11821|MIM:188825|Ensembl:ENSG00000035862|HPRD:01784|Vega:OTTHUMG00000154517 17 17q25 TIMP metallopeptidase inhibitor 2 protein-coding TIMP metallopeptidase inhibitor 2 Both gain- and loss-of-function studies showed that miR-221/222 regulate cell proliferation, the cell cycle and apoptosis, in addition to, invasion, metastasis, and angiogenesis in glioma cell lines. Subsequent investigations revealed that TIMP2 is a direct target of miR-221/222, and overexpression of TIMP2 reduced the miR-221/222-mediated invasion, metastasis, and angiogenesis of glioma cells. Taken together, our results suggest that the suppression of miR-221/222 may be a feasible approach for inhibiting the malignant behaviors of glioma. 1458 miR-221 hsa-miR-221-3p,hsa-miR-221-5p MIMAT0000278,MIMAT0004568 miRNA TNFSF10 apoptosis Homo sapiens bladder cancer cell 19767219 9606 8743 APO2L|Apo-2L|CD253|TL2|TRAIL HGNC:11925|MIM:603598|Ensembl:ENSG00000121858|HPRD:04670|Vega:OTTHUMG00000156917 3 3q26 tumor necrosis factor (ligand) superfamily, member 10 protein-coding tumor necrosis factor (ligand) superfamily, member 10 Human miRNA-221 was significantly up-regulated in bladder cancer T24 cells and RT4 cells compared to human normal urothelial cells. T24 cell was TRAIL-resistant cell line. MiRNA-221 silencing predisposed T24 cells to undergo apoptosis induced by TRAIL and resulted in an up-modulation of cyclin-dependent kinase inhibitor p27Kip1. MiRNA-221 suppression promoted the activation of caspase 3 induced by TRAIL in T24 cells. 1459 miR-221 hsa-miR-221-5p,hsa-miR-221-3p MIMAT0004568,MIMAT0000278 miRNA apoptosis Homo sapiens pancreatic cancer cells 19730150 9606 1027 CDKN4|KIP1|MEN1B|MEN4|P27KIP1 HGNC:1785|MIM:600778|Ensembl:ENSG00000111276|HPRD:02867|Vega:OTTHUMG00000149914|M2D:hsa-miR-221 12 12p13.1-p12 cyclin-dependent kinase inhibitor 1B (p27, Kip1) protein coding cyclin-dependent kinase inhibitor 1B (p27, Kip1) cyclin-dependent kinase i Antisense inhibition of microRNA-21 or -221 arrests cell cycle, induces apoptosis, and sensitizes the effects of gemcitabine in pancreatic adenocarcinoma. 1460 miR-221 hsa-miR-221-3p,hsa-miR-221-5p MIMAT0000278,MIMAT0004568 miRNA apoptosis Homo sapiens epithelial cancer cell 21042732 9606 MiR-221 and miR-222 (miR-221/222) are frequently up-regulated in human epithelial cancers. However, the mechanism of miR-221/222 action involved in carcinogenesis has not been extensively studied. Here, we found that reduction of miR-221/222 inhibited cell proliferation and induced mitochondrial-mediated apoptosis in human epithelial cancer cells (A549 lung cancer and MCF-7 breast cancer cells). Bioinformatics and luciferase reporter assays showed that miR-221/222 co-modulated the p53 upregulated modulator of apoptosis (PUMA) expression by directly targeting the binding site within the 3'UTR. Together, these findings suggest that PUMA is a direct target of miR-221/222 that functions as an endogenous apoptosis regulator in these epithelial cancers. 1461 miR-221 hsa-miR-221-3p,hsa-miR-221-5p MIMAT0000278,MIMAT0004568 miRNA apoptosis Homo sapiens colorectal carcinoma cell 21515467 9606 The miR-221-specific inhibitor, anti-miR-221, significantly inhibited the expression of miR-221 in Caco2 cells and suppressed the cell proliferation, causing also obvious cell apoptosis (P<0.01). 1462 miR-221 hsa-miR-221-3p,hsa-miR-221-5p MIMAT0000278,MIMAT0004568 miRNA apoptosis Homo sapiens glioma cells 22681957 9606 7078 SFD|K222|K222TA2|HSMRK222 HGNC:11822|ENSG00000100234|HPRD:01785|MIM:188826|Vega:OTTHUMG00000030784 22 22q12.3 TIMP metallopeptidase inhibitor 3 protein coding TIMP metallopeptidase inhibitor 3 MiR-221 and miR-222 (miR-221/222), upregulated in gliomas, can regulate glioma cell cycle progression and apoptosis, respectively. 1463 miR-221 hsa-miR-221-3p,hsa-miR-221-5p MIMAT0000278,MIMAT0004568 miRNA apoptosis Homo sapiens hepatocellular carcinoma cell 23320393 9606 Functionally, cell growth was inhibited, cell cycle was arrested in G1/S-phase and apoptosis was increased by miR-221 inhibitor in vitro. Likewise, miR-221 mimic accelerated the cell growth. 1464 miR-221 hsa-miR-221-3p,hsa-miR-221-5p MIMAT0000278,MIMAT0004568 miRNA apoptosis Homo sapiens glioblastoma cell 24780067 9606 In the present study, we explored the effects of miRNA-221 on BCNU-resistant glioma cells and the possible molecular mechanisms by which miRNA-221 mediated the cell proliferation, survival, apoptosis and BCNU resistance were investigated. 1465 miR-221 hsa-miR-221-3p,hsa-miR-221-5p MIMAT0000278,MIMAT0004568 miRNA apoptosis Homo sapiens lung cancer cell 25641933 9606 Cell cycle and apoptosis analyses revealed that growth suppression by miR-221 and miR-222 occurred through intra-S-phase arrest and/or apoptosis. Finally, lung cancer cell lines transfected with miR-221 or miR-222 became more sensitive to the S-phase targeting drugs, possibly due to an increased S-phase population. In conclusion, our data are the first to show tumor-suppressive effects of miR-221 and miR-222 on lung cancer, warranting testing their potential as therapeutics for the disease. 1466 miR-222 hsa-miR-222-3p,hsa-miR-222-5p MIMAT0000279,MIMAT0004569 miRNA ADAM17 apoptosis down Homo sapiens colorectal carcinoma cells 22677042 9606 6868 ADAM18|CD156B|CSVP|NISBD|TACE HGNC:195|MIM:603639|Ensembl:ENSG00000151694|HPRD:04703|Vega:OTTHUMG00000090425 2 2p25 ADAM metallopeptidase domain 17 protein-coding ADAM metallopeptidase domain 17 We found that elevated levels of miR-222 in the mimics-transfected HCT116/L-OHP and HCT-8/VCR cells reduced the ADAM-17 protein level and the luciferase activity of an ADAM-17 3' untranslated region-based reporter and sensitized these cells' apoptosis to some anticancer drugs. 1467 miR-222 hsa-miR-222-3p,hsa-miR-222-5p MIMAT0000279,MIMAT0004569 miRNA AKT1 apoptosis Homo sapiens hepatocellular carcinoma cell 25096647 9606 207 AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA HGNC:391|MIM:164730|Ensembl:ENSG00000142208|HPRD:01261|Vega:OTTHUMG00000170795 14 14q32.32 v-akt murine thymoma viral oncogene homolog 1 protein-coding v-akt murine thymoma viral oncogene homolog 1 Importantly, our study also showed that miR-222 could regulate the expression of phosphorylation PI3K and AKT, which might contribute to miR-222 conferred SOR resistance in HepG2 cells. In conclusion, this study demonstrates that miR-222 can promote cell proliferation, migration and invasion, and decrease cell apoptosis, as well as enhance the resistance of HCC cells to sorafenib miR-222 through activating the PI3K/AKT signaling pathway. 1468 miR-222 hsa-miR-222-5p,hsa-miR-222-3p MIMAT0004569,MIMAT0000279 miRNA BBC3 apoptosis down Homo sapiens glioblastoma cells 20813046 9606 27113 JFY-1|JFY1|PUMA HGNC:17868|MIM:605854|Ensembl:ENSG00000105327|HPRD:16165|Vega:OTTHUMG00000183489 19 19q13.3-q13.4 BCL2 binding component 3 protein-coding BCL2 binding component 3 bcl-2-binding component 3 Here we showed that miR-221/222 inhibited cell apoptosis by targeting pro-apoptotic gene PUMA in human glioma cells. Enforced expression of miR-22/222 induced cell survival whereas knockdown of miR-221/222 rendered cells to apoptosis. 1469 miR-222 hsa-miR-222-5p,hsa-miR-222-3p MIMAT0004569,MIMAT0000279 miRNA BBC3 apoptosis Homo sapiens epithelial cancer cell 21042732 9606 27113 JFY-1|JFY1|PUMA HGNC:17868|MIM:605854|Ensembl:ENSG00000105327|HPRD:16165|Vega:OTTHUMG00000183489 19 19q13.3-q13.4 BCL2 binding component 3 protein-coding BCL2 binding component 3 Bioinformatics and luciferase reporter assays showed that miR-221/222 co-modulated the p53 upregulated modulator of apoptosis (PUMA) expression by directly targeting the binding site within the 3'UTR. Together, these findings suggest that PUMA is a direct target of miR-221/222 that functions as an endogenous apoptosis regulator in these epithelial cancers. 1470 miR-222 hsa-miR-222-3p,hsa-miR-222-5p MIMAT0000279,MIMAT0004569 miRNA BBC3 apoptosis down Homo sapiens oral squamous cell 24452416 9606 27113 JFY-1|JFY1|PUMA HGNC:17868|MIM:605854|Ensembl:ENSG00000105327|HPRD:16165|Vega:OTTHUMG00000183489 19 19q13.3-q13.4 BCL2 binding component 3 protein-coding BCL2 binding component 3 In the Pre-miR-222 transfection group showed increased expression of miR-222 and decreased expression of PUMA, enhanced proliferation and invasion abilities, and decreased apoptosis. 1471 miR-222 hsa-miR-222-3p,hsa-miR-222-5p MIMAT0000279,MIMAT0004569 miRNA BBC3 apoptosis up Homo sapiens oral squamous cell 25474084 9606 27113 JFY-1|JFY1|PUMA HGNC:17868|MIM:605854|Ensembl:ENSG00000105327|HPRD:16165|Vega:OTTHUMG00000183489 19 19q13.3-q13.4 BCL2 binding component 3 protein-coding BCL2 binding component 3 The present study explored the role and mechanism of miR-222 in increasing the expression of p53 up-regulated modulator of apoptosis (PUMA) and enhancing the sensitivity of OSCC to cisplatin (CDDP) 1472 miR-222 hsa-miR-222-5p,hsa-miR-222-3p MIMAT0004569,MIMAT0000279 miRNA CDKN1B apoptosis down Homo sapiens lung cancer cells 18246122 9606 1027 CDKN4|KIP1|MEN1B|MEN4|P27KIP1 HGNC:1785|MIM:600778|Ensembl:ENSG00000111276|HPRD:02867|Vega:OTTHUMG00000149914 12 12p13.1-p12 cyclin-dependent kinase inhibitor 1B (p27, Kip1) protein-coding cyclin-dependent kinase inhibitor 1B (p27, Kip1) cyclin-dependent kinase i MiR-221 and -222 target the 3'-UTR of Kit and p27(kip1) mRNAs, but interfere with TRAIL signaling mainly through p27(kip1).High expression levels of miR-221 and -222 are needed to maintain the TRAIL-resistant phenotype. 1473 miR-222 hsa-miR-222-5p,hsa-miR-222-3p MIMAT0004569,MIMAT0000279 miRNA CDKN1B apoptosis Homo sapiens HCC cell 20624000 9606 1027 CDKN4|KIP1|MEN1B|MEN4|P27KIP1 HGNC:1785|MIM:600778|Ensembl:ENSG00000111276|HPRD:02867|Vega:OTTHUMG00000149914 12 12p13.1-p12 cyclin-dependent kinase inhibitor 1B (p27, Kip1) protein-coding cyclin-dependent kinase inhibitor 1B (p27, Kip1) Cancer cells are relatively resistant to endoplasmic reticulum (ER) stress-induced apoptosis. However, the underlying mechanisms remain largely unclear. We observed that the microRNAs miR-221/222 are associated with apoptosis regulation under ER stress in human hepatocellular carcinoma (HCC) cells. Induction of ER stress does not trigger significant apoptosis but obviously causes downregulation of miR-221/222 in HCC cells. In these cells, ER stress-induced apoptosis is enhanced by miR-221/222 mimics and attenuated by miR-221/222 inhibitors. miR-221/222 promoted-apoptosis under ER stress is associated with p27(Kip1)- and MEK/ERK-mediated cell cycle regulation. Our results suggest that suppression of miR-221/222 plays a crucial role in the protection against apoptosis induced by ER stress in HCC cells. 1474 miR-222 hsa-miR-222-5p,hsa-miR-222-3p MIMAT0004569,MIMAT0000279 miRNA CDKN1B apoptosis Homo sapiens hepatocarcinoma cell 21586237 9606 1027 CDKN4|KIP1|MEN1B|MEN4|P27KIP1 HGNC:1785|MIM:600778|Ensembl:ENSG00000111276|HPRD:02867|Vega:OTTHUMG00000149914 12 12p13.1-p12 cyclin-dependent kinase inhibitor 1B (p27, Kip1) protein-coding cyclin-dependent kinase inhibitor 1B (p27, Kip1) MiR-221/222 were downregulated by endoplasmic reticulum stress in human hepatocellular carcinoma cells, which subsequently protected human hepatocellular carcinoma cells against endoplasmic reticulum stress-induced apoptosis through p27Kip1 regulation. 1475 miR-222 hsa-miR-222-5p,hsa-miR-222-3p MIMAT0004569,MIMAT0000279 miRNA DIRAS3 apoptosis Homo sapiens prostate cancer cell 21071579 9606 9077 ARHI|NOEY2 HGNC:687|MIM:605193|Ensembl:ENSG00000162595|HPRD:05547|Vega:OTTHUMG00000009544 1 1p31 DIRAS family, GTP-binding RAS-like 3 protein-coding DIRAS family, GTP-binding RAS-like 3 Overexpression of ARHI inhibited cell proliferation, colony formation, invasion, and induced apoptosis. Further studies on a new mechanism of ARHI downregulation showed a significant inverse relationship between ARHI and miR-221 and 222, which were upregulated in prostate cancer cell lines. 1476 miR-222 hsa-miR-222-3p,hsa-miR-222-5p MIMAT0000279,MIMAT0004569 miRNA DKK2 apoptosis down Homo sapiens glioma cell 23587485 9606 27123 DKK-2 HGNC:2892|MIM:605415|Ensembl:ENSG00000155011|HPRD:05658|Vega:OTTHUMG00000131216 4 4q25 dickkopf WNT signaling pathway inhibitor 2 protein-coding dickkopf WNT signaling pathway inhibitor 2 MiR-222 in glioma can regulate cell cycle progression and apoptosis. However, the relationship between miR-222 and Wnt/¦Â-catenin signaling pathway in glioma remains unknown. Here, we found that the Dickkopf-2 gene (DKK2) was a direct target of miR-222 by target prediction analysis and dual luciferase reporter assay. 1477 miR-222 hsa-miR-222-5p,hsa-miR-222-3p MIMAT0004569,MIMAT0000279 miRNA KIT apoptosis down Homo sapiens lung cancer cells 18246122 9606 3815 C-Kit|CD117|PBT|SCFR HGNC:6342|MIM:164920|Ensembl:ENSG00000157404|HPRD:01287|Vega:OTTHUMG00000128713 4 4q12 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog protein-coding v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog cyclin-dependent kinase i MiR-221 and -222 target the 3'-UTR of Kit and p27(kip1) mRNAs, but interfere with TRAIL signaling mainly through p27(kip1).High expression levels of miR-221 and -222 are needed to maintain the TRAIL-resistant phenotype. 1478 miR-222 hsa-miR-222-5p,hsa-miR-222-3p MIMAT0004569,MIMAT0000279 miRNA MAP2K7 apoptosis Homo sapiens HCC cell 20624000 9606 5609 JNKK2|MAPKK7|MEK|MEK 7|MKK7|PRKMK7|SAPKK-4|SAPKK4 HGNC:6847|MIM:603014|Ensembl:ENSG00000076984|Vega:OTTHUMG00000137368 19 19p13.3-p13.2 mitogen-activated protein kinase kinase 7 protein-coding mitogen-activated protein kinase kinase 7 Cancer cells are relatively resistant to endoplasmic reticulum (ER) stress-induced apoptosis. However, the underlying mechanisms remain largely unclear. We observed that the microRNAs miR-221/222 are associated with apoptosis regulation under ER stress in human hepatocellular carcinoma (HCC) cells. Induction of ER stress does not trigger significant apoptosis but obviously causes downregulation of miR-221/222 in HCC cells. In these cells, ER stress-induced apoptosis is enhanced by miR-221/222 mimics and attenuated by miR-221/222 inhibitors. miR-221/222 promoted-apoptosis under ER stress is associated with p27(Kip1)- and MEK/ERK-mediated cell cycle regulation. Our results suggest that suppression of miR-221/222 plays a crucial role in the protection against apoptosis induced by ER stress in HCC cells. 1479 miR-222 hsa-miR-222-5p,hsa-miR-222-3p MIMAT0004569,MIMAT0000279 miRNA MAPK1 apoptosis Homo sapiens HCC cell 20624000 9606 5594 ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK HGNC:6871|MIM:176948|Ensembl:ENSG00000100030|HPRD:01496|Vega:OTTHUMG00000030508 22 22q11.21 mitogen-activated protein kinase 1 protein-coding mitogen-activated protein kinase 1 Cancer cells are relatively resistant to endoplasmic reticulum (ER) stress-induced apoptosis. However, the underlying mechanisms remain largely unclear. We observed that the microRNAs miR-221/222 are associated with apoptosis regulation under ER stress in human hepatocellular carcinoma (HCC) cells. Induction of ER stress does not trigger significant apoptosis but obviously causes downregulation of miR-221/222 in HCC cells. In these cells, ER stress-induced apoptosis is enhanced by miR-221/222 mimics and attenuated by miR-221/222 inhibitors. miR-221/222 promoted-apoptosis under ER stress is associated with p27(Kip1)- and MEK/ERK-mediated cell cycle regulation. Our results suggest that suppression of miR-221/222 plays a crucial role in the protection against apoptosis induced by ER stress in HCC cells. 1480 miR-222 hsa-miR-222-3p,hsa-miR-222-5p MIMAT0000279,MIMAT0004569 miRNA PIK3CA apoptosis Homo sapiens hepatocellular carcinoma cell 25096647 9606 5290 CLOVE|CWS5|MCAP|MCM|MCMTC|PI3K|p110-alpha HGNC:8975|MIM:171834|HPRD:01382 3 3q26.3 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha protein-coding phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha Importantly, our study also showed that miR-222 could regulate the expression of phosphorylation PI3K and AKT, which might contribute to miR-222 conferred SOR resistance in HepG2 cells. In conclusion, this study demonstrates that miR-222 can promote cell proliferation, migration and invasion, and decrease cell apoptosis, as well as enhance the resistance of HCC cells to sorafenib miR-222 through activating the PI3K/AKT signaling pathway. 1481 miR-222 hsa-miR-222-3p,hsa-miR-222-5p MIMAT0000279,MIMAT0004569 miRNA PTEN apoptosis up Homo sapiens 21481725 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog We identified the PTEN gene as a target of miRNA-221/-222. Furthermore, we found that knocking down miRNA-221/-222 by antisense oligonucleotides upregulated PTEN expression. Upregulated PTEN expression suppressed AKT activity and increased radiation-induced apoptosis, resulting in enhancement of radiosensitivity in tumor cells. 1482 miR-222 hsa-miR-222-3p,hsa-miR-222-5p MIMAT0000279,MIMAT0004569 miRNA TIMP2 apoptosis down Homo sapiens glioma cell 25731730 9606 7077 CSC-21K|DDC8 HGNC:11821|MIM:188825|Ensembl:ENSG00000035862|HPRD:01784|Vega:OTTHUMG00000154517 17 17q25 TIMP metallopeptidase inhibitor 2 protein-coding TIMP metallopeptidase inhibitor 2 Both gain- and loss-of-function studies showed that miR-221/222 regulate cell proliferation, the cell cycle and apoptosis, in addition to, invasion, metastasis, and angiogenesis in glioma cell lines. Subsequent investigations revealed that TIMP2 is a direct target of miR-221/222, and overexpression of TIMP2 reduced the miR-221/222-mediated invasion, metastasis, and angiogenesis of glioma cells. Taken together, our results suggest that the suppression of miR-221/222 may be a feasible approach for inhibiting the malignant behaviors of glioma. 1483 miR-222 hsa-miR-222-3p,hsa-miR-222-5p MIMAT0000279,MIMAT0004569 miRNA apoptosis Homo sapiens epithelial cancer cell 21042732 9606 MiR-221 and miR-222 (miR-221/222) are frequently up-regulated in human epithelial cancers. However, the mechanism of miR-221/222 action involved in carcinogenesis has not been extensively studied. Here, we found that reduction of miR-221/222 inhibited cell proliferation and induced mitochondrial-mediated apoptosis in human epithelial cancer cells (A549 lung cancer and MCF-7 breast cancer cells). Bioinformatics and luciferase reporter assays showed that miR-221/222 co-modulated the p53 upregulated modulator of apoptosis (PUMA) expression by directly targeting the binding site within the 3'UTR. Together, these findings suggest that PUMA is a direct target of miR-221/222 that functions as an endogenous apoptosis regulator in these epithelial cancers. 1484 miR-222 hsa-miR-222-3p,hsa-miR-222-5p, MIMAT0000279,MIMAT0004569 miRNA apoptosis Homo sapiens glioma cells 22681957 9606 7078 SFD|K222|K222TA2|HSMRK222 HGNC:11822|ENSG00000100234|HPRD:01785|MIM:188826|Vega:OTTHUMG00000030784 22 22q12.3 TIMP metallopeptidase inhibitor 3 protein coding TIMP metallopeptidase inhibitor 3 MiR-221 and miR-222 (miR-221/222), upregulated in gliomas, can regulate glioma cell cycle progression and apoptosis, respectively. 1485 miR-222 hsa-miR-222-3p,hsa-miR-222-5p MIMAT0000279,MIMAT0004569 miRNA apoptosis Homo sapiens leukemic cells 23522449 9606 In our in vitro studies miR-222 significantly inhibited proliferation, and caused cell cycle arrest and apoptosis in leukemic cells. 1486 miR-222 hsa-miR-222-3p,hsa-miR-222-5p MIMAT0000279,MIMAT0004569 miRNA apoptosis Homo sapiens lung cancer cell 25641933 9606 Cell cycle and apoptosis analyses revealed that growth suppression by miR-221 and miR-222 occurred through intra-S-phase arrest and/or apoptosis. Finally, lung cancer cell lines transfected with miR-221 or miR-222 became more sensitive to the S-phase targeting drugs, possibly due to an increased S-phase population. In conclusion, our data are the first to show tumor-suppressive effects of miR-221 and miR-222 on lung cancer, warranting testing their potential as therapeutics for the disease. 1487 miR-223 hsa-miR-223-3p,hsa-miR-223-5p MIMAT0004570,MIMAT0000280 miRNA AKT1 apoptosis down Homo sapiens osteosarcoma cell 23208072 9606 207 AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA HGNC:391|MIM:164730|Ensembl:ENSG00000142208|HPRD:01261|Vega:OTTHUMG00000170795 14 14q32.32 v-akt murine thymoma viral oncogene homolog 1 protein-coding v-akt murine thymoma viral oncogene homolog 1 Furthermore, overexpression of miR-223 results in significant inhibition of cell growth on culture plates. Moreover, cancer cells showed significant G0/G1 arrest and increased apoptosis due to gene silencing. Protein levels of PI3k, p-Akt, mTOR, and Bcl-2 were decreased, whereas Bid levels were increased. Microvessel density as assessed by CD34 levels and cell growth by PCNA levels decreased according to immunohistochemical analysis. 1488 miR-223 hsa-miR-223-3p,hsa-miR-223-5p MIMAT0004570,MIMAT0000280 miRNA BCL2 apoptosis down Homo sapiens osteosarcoma cell 23208072 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Furthermore, overexpression of miR-223 results in significant inhibition of cell growth on culture plates. Moreover, cancer cells showed significant G0/G1 arrest and increased apoptosis due to gene silencing. Protein levels of PI3k, p-Akt, mTOR, and Bcl-2 were decreased, whereas Bid levels were increased. Microvessel density as assessed by CD34 levels and cell growth by PCNA levels decreased according to immunohistochemical analysis. 1489 miR-223 hsa-miR-223-3p,hsa-miR-223-5p MIMAT0000280,MIMAT0004570 miRNA BID apoptosis up Homo sapiens osteosarcoma cell 23208072 9606 637 FP497 HGNC:1050|MIM:601997|Ensembl:ENSG00000015475|HPRD:03590|Vega:OTTHUMG00000150087 22 22q11.1 BH3 interacting domain death agonist protein-coding BH3 interacting domain death agonist Furthermore, overexpression of miR-223 results in significant inhibition of cell growth on culture plates. Moreover, cancer cells showed significant G0/G1 arrest and increased apoptosis due to gene silencing. Protein levels of PI3k, p-Akt, mTOR, and Bcl-2 were decreased, whereas Bid levels were increased. Microvessel density as assessed by CD34 levels and cell growth by PCNA levels decreased according to immunohistochemical analysis. 1490 miR-223 hsa-miR-223-3p,hsa-miR-223-5p MIMAT0004570,MIMAT0000280 miRNA FBXW7 apoptosis down Homo sapiens Gastric cancer cell 22270966 9606 55294 AGO|CDC4|FBW6|FBW7|FBX30|FBXO30|FBXW6|SEL-10|SEL10|hAgo|hCdc4 HGNC:16712|MIM:606278|Ensembl:ENSG00000109670|HPRD:05888|Vega:OTTHUMG00000185246 4 4q31.3 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase protein-coding F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase Gastric cancer cell line SGC7901, transfected with miR-223, showed significant reduction in cellular apoptosis and increased proliferation and invasion in vitro. Similar results were found in tumorigenesis assays performed in nude mice. Moreover, 19 of 22 cancer tissue samples highly expressed miR-223, when compared with patient-matched normal gastric mucosa. Specifically, patients with lymph node metastasis or metastatic disease (M1) at an advanced pathological stage showed significantly higher expression of miR-223. FBXW7/hCdc4 protein (FBW7) levels in gastric cancer cases were inversely correlated with miR-223 expression. Overexpression of miR-223 in gastric cancer cell lines decreased FBW7 expression at the translational level and decreased FBXW7/hCdc4-driven luciferase-reporter activity. 1491 miR-223 hsa-miR-223-3p,hsa-miR-223-5p MIMAT0000280,MIMAT0004570 miRNA FBXW7 apoptosis down Homo sapiens gastric cancer cell 25159729 9606 55294 AGO|CDC4|FBW6|FBW7|FBX30|FBXO30|FBXW6|SEL-10|SEL10|hAgo|hCdc4 HGNC:16712|MIM:606278|Ensembl:ENSG00000109670|HPRD:05888|Vega:OTTHUMG00000185246 4 4q31.3 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase protein-coding F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase Overexpression of miR-223 decreased FBXW7 expression and the sensitivity of GC cells to trastuzumab, while suppression of miR-223 restored FBXW7 expression and the sensitivity of GC cells to trastuzumab. Moreover, overexpression of miR-223 significantly suppressed trastuzumab-induced apoptosis. This study is the first report to reveal that the miR-223/FBXW7 pathway regulates the sensitivity of a HER2-positive GC cell line to trastuzumab through the modulation of apoptosis. 1492 miR-223 hsa-miR-223-3p,hsa-miR-223-5p MIMAT0004570,MIMAT0000280 miRNA IGF1R apoptosis Homo sapiens embryonic stem cell 24250812 9606 3480 CD221|IGFIR|IGFR|JTK13 HGNC:5465|MIM:147370|Ensembl:ENSG00000140443|HPRD:00932|Vega:OTTHUMG00000149851 15 15q26.3 insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor Based on the identification of complementary binding sites in miR-223 and IGF-1R mRNA, it is proposed that miR-223 acts as a local regulator of IGF-1R. Therefore, levels of miR-223 were detected in differentiated versus undifferentiated hESCs.In addition, proliferation, apoptosis, and differentiation were assayed in these two hESC populations and were compared in the presence of exogenous miR-223 and miR-223 inhibitor. Inhibition of miR-223 was found to maintain the undifferentiated state of hESCs, while addition of miR-223 induced differentiation. Furthermore, these effects were found to be likely dependent on IGF-1R/Akt signaling. 1493 miR-223 hsa-miR-223-3p,hsa-miR-223-5p MIMAT0004570,MIMAT0000280 miRNA IGF1R apoptosis down Homo sapiens endothelial cell 24307738 9606 3480 CD221|IGFIR|IGFR|JTK13 HGNC:5465|MIM:147370|Ensembl:ENSG00000140443|HPRD:00932|Vega:OTTHUMG00000149851 15 15q26.3 insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor Finally, in HUVECs, exogenous platelet miR-223 decreased the level of insulin-like growth factor 1 receptor and thus promoted HUVEC apoptosis induced by advanced glycation end products. 1494 miR-223 hsa-miR-223-3p,hsa-miR-223-5p MIMAT0000280,MIMAT0004570 miRNA MTOR apoptosis down Homo sapiens osteosarcoma cell 23208072 9606 2475 FRAP|FRAP1|FRAP2|RAFT1|RAPT1 HGNC:3942|MIM:601231|Ensembl:ENSG00000198793|HPRD:03134|Vega:OTTHUMG00000002001 1 1p36.2 mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) Furthermore, overexpression of miR-223 results in significant inhibition of cell growth on culture plates. Moreover, cancer cells showed significant G0/G1 arrest and increased apoptosis due to gene silencing. Protein levels of PI3k, p-Akt, mTOR, and Bcl-2 were decreased, whereas Bid levels were increased. Microvessel density as assessed by CD34 levels and cell growth by PCNA levels decreased according to immunohistochemical analysis. 1495 miR-223 hsa-miR-223-3p,hsa-miR-223-5p MIMAT0000280,MIMAT0004570 miRNA PIK3CA apoptosis down Homo sapiens osteosarcoma cell 23208072 9606 5290 CLOVE|CWS5|MCAP|MCM|MCMTC|PI3K|p110-alpha HGNC:8975|MIM:171834|HPRD:01382 3 3q26.3 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha protein-coding phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha Furthermore, overexpression of miR-223 results in significant inhibition of cell growth on culture plates. Moreover, cancer cells showed significant G0/G1 arrest and increased apoptosis due to gene silencing. Protein levels of PI3k, p-Akt, mTOR, and Bcl-2 were decreased, whereas Bid levels were increased. Microvessel density as assessed by CD34 levels and cell growth by PCNA levels decreased according to immunohistochemical analysis. 1496 miR-223 hsa-miR-223-3p,hsa-miR-223-5p MIMAT0000280,MIMAT0004570 miRNA SLC8A1 apoptosis down Homo sapiens penile?cell 25481039 9606 6546 NCX1 HGNC:11068|MIM:182305|Ensembl:ENSG00000183023|HPRD:01659 2 2p22.1 solute carrier family 8 (sodium/calcium exchanger), member 1 protein-coding solute carrier family 8 (sodium/calcium exchanger), member 1 Down-regulation of the SLC8A1 gene, most likely mediated by its regulator miR-223, can lead to reduced calcium levels in PeCa and, consequently, to suppression of apoptosis and increased tumor cell proliferation. These data suggest that the miR-223-NCX1-calcium-signaling axis may represent a potential therapeutic approach in PeCa. 1497 miR-224 hsa-miR-224-5p,hsa-miR-224-3p MIMAT0000281,MIMAT0009198 miRNA API5 apoptosis Homo sapiens hepatocellular carcinoma cells 18319255 9606 8539 AAC-11|AAC11 HGNC:594|MIM:609774|Ensembl:ENSG00000166181|HPRD:16500|Vega:OTTHUMG00000166395 11 11p11.2 apoptosis inhibitor 5 protein-coding apoptosis inhibitor 5 FIF|antiapoptosis clone 1 Profiling microRNA expression in hepatocellular carcinoma reveals microRNA-224 up-regulation and apoptosis inhibitor-5 as a microRNA-224-specific target. 1498 miR-224 hsa-miR-224-5p,hsa-miR-224-3p MIMAT0000281,MIMAT0009198 miRNA API5 apoptosis down Homo sapiens mesenchymal stem cells 22326282 9606 8539 AAC-11|AAC11 HGNC:594|MIM:609774|Ensembl:ENSG00000166181|HPRD:16500|Vega:OTTHUMG00000166395 11 11p11.2 apoptosis inhibitor 5 protein-coding apoptosis inhibitor 5 We could confirm the already known regulation of the apoptosis inhibitor API5 by miR-224 and could further identify three novel miR-224 target genes (SMAD5, SLMAP, H3.3B). 1499 miR-224 hsa-miR-224-5p,hsa-miR-224-3p MIMAT0000281,MIMAT0009198 miRNA API5 apoptosis up Homo sapiens systemic lupus erythematosus T cells 23199328 9606 8539 AAC-11|AAC11 HGNC:594|MIM:609774|Ensembl:ENSG00000166181|HPRD:16500|Vega:OTTHUMG00000166395 11 11p11.2 apoptosis inhibitor 5 protein-coding apoptosis inhibitor 5 We further found that STAT1 mRNA targeted by miR-145 was over-expressed and apoptosis inhibitory protein 5 (API5) mRNA targeted by miR-224 was under-expressed in SLE T cells. 1500 miR-224 hsa-miR-224-5p,hsa-miR-224-3p MIMAT0000281,MIMAT0009198 miRNA BCL2 apoptosis down Homo sapiens hepatocellular carcinoma cell 22989374 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 The high-ranking genes CDC42, CDH1, PAK2, BCL-2, and MAPK1 were confirmed as important targets of miR-224 and involvement in hepatocarcinogenesis. Overexpression of miR-224 significantly in Hek293 and Huh7 cells altered the expression levels of CDC42, CDH1, PAK2, and BCL-2 at both mRNA and protein levels. 1501 miR-224 hsa-miR-224-5p,hsa-miR-224-3p MIMAT0000281,MIMAT0009198 miRNA BCL2 apoptosis down Homo sapiens gastric cancer cell 24796455 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Flow cytometry indicated that the apoptotic index was (15.68 ¡À 1.46)% in the miR-224 ASO group and (3.36 ¡À 0.88)% in the control group (P < 0.01). In addition, the expressions of Bcl2 mRNA and protein were 1.05 ¡À 0.04 and 0.21 ¡À 0.03 in the miR-224 ASO group, significantly lower than that in the control group (4.87 ¡À 0.96 and 0.88 ¡À 0.09, P < 0.01). The in vivo study further showed that the tumor volume in the experimental group is significantly smaller than that in the control group (P = 0.01). 1502 miR-224 hsa-miR-224-5p,hsa-miR-224-3p MIMAT0000281,MIMAT0009198 miRNA CDC42 apoptosis down Homo sapiens hepatocellular carcinoma cell 22989374 9606 998 CDC42Hs|G25K HGNC:1736|MIM:116952|Ensembl:ENSG00000070831|HPRD:00309|Vega:OTTHUMG00000002753 1 1p36.1 cell division cycle 42 protein-coding cell division cycle 42 The high-ranking genes CDC42, CDH1, PAK2, BCL-2, and MAPK1 were confirmed as important targets of miR-224 and involvement in hepatocarcinogenesis. Overexpression of miR-224 significantly in Hek293 and Huh7 cells altered the expression levels of CDC42, CDH1, PAK2, and BCL-2 at both mRNA and protein levels. 1503 miR-224 hsa-miR-224-5p,hsa-miR-224-3p MIMAT0000281,MIMAT0009198 miRNA CDH1 apoptosis down Homo sapiens hepatocellular carcinoma cell 22989374 9606 999 Arc-1|CD324|CDHE|ECAD|LCAM|UVO HGNC:1748|MIM:192090|Ensembl:ENSG00000039068|HPRD:01885|Vega:OTTHUMG00000137561 16 16q22.1 cadherin 1, type 1, E-cadherin (epithelial) protein-coding cadherin 1, type 1, E-cadherin (epithelial) The high-ranking genes CDC42, CDH1, PAK2, BCL-2, and MAPK1 were confirmed as important targets of miR-224 and involvement in hepatocarcinogenesis. Overexpression of miR-224 significantly in Hek293 and Huh7 cells altered the expression levels of CDC42, CDH1, PAK2, and BCL-2 at both mRNA and protein levels. 1504 miR-224 hsa-miR-224-5p,hsa-miR-224-3p MIMAT0000281,MIMAT0009198 miRNA CDKN1A apoptosis down Homo sapiens 24921914 9606 1026 CAP20|CDKN1|CIP1|MDA-6|P21|SDI1|WAF1|p21CIP1 HGNC:1784|MIM:116899|Ensembl:ENSG00000124762|HPRD:00298|Vega:OTTHUMG00000014603 6 6p21.2 cyclin-dependent kinase inhibitor 1A (p21, Cip1) protein-coding cyclin-dependent kinase inhibitor 1A (p21, Cip1) MiR-224 promotes the chemoresistance of human lung adenocarcinoma cells to cisplatin via regulating G?/S transition and apoptosis by targeting p21(WAF1/CIP1). 1505 miR-224 hsa-miR-224-5p,hsa-miR-224-3p MIMAT0000281,MIMAT0009198 miRNA PAK2 apoptosis down Homo sapiens hepatocellular carcinoma cell 22989374 9606 5062 PAK65|PAKgamma HGNC:8591|MIM:605022|Ensembl:ENSG00000180370|HPRD:05428|Vega:OTTHUMG00000155534 3 3q29 p21 protein (Cdc42/Rac)-activated kinase 2 protein-coding p21 protein (Cdc42/Rac)-activated kinase 2 The high-ranking genes CDC42, CDH1, PAK2, BCL-2, and MAPK1 were confirmed as important targets of miR-224 and involvement in hepatocarcinogenesis. Overexpression of miR-224 significantly in Hek293 and Huh7 cells altered the expression levels of CDC42, CDH1, PAK2, and BCL-2 at both mRNA and protein levels. 1506 miR-224 hsa-miR-224-5p,hsa-miR-224-3p MIMAT0000281,MIMAT0009198 miRNA TRIB1 apoptosis down Homo sapiens prostate cancer cell 24382668 9606 10221 C8FW|GIG-2|GIG2|SKIP1|TRB-1|TRB1 HGNC:16891|MIM:609461|Ensembl:ENSG00000173334|HPRD:09863|Vega:OTTHUMG00000165007 8 8q24.13 tribbles pseudokinase 1 protein-coding tribbles pseudokinase 1 Forced expression of miR-224 suppressed PCa cell proliferation, invasion and migration, and promoted cell apoptosis by downregulating TRIB1. 1507 miR-224 hsa-miR-224-5p,hsa-miR-224-3p MIMAT0000281,MIMAT0009198 miRNA apoptosis Homo sapiens NSCLC cell 25410592 9606 MiR-224 mimics in NSCLC A549 cells was able to reduce cell proliferation, invasion, and migration, and promote cell apoptosis. 1508 miR-224-5p hsa-miR-224-5p MIMAT0000281 miRNA PRKCD apoptosis Homo sapiens 25017423 9606 5580 CVID9|MAY1|PKCD|nPKC-delta HGNC:9399|MIM:176977|Ensembl:ENSG00000163932|HPRD:01501|Vega:OTTHUMG00000133659 3 3p21.31 protein kinase C, delta protein-coding protein kinase C, delta It is of note that enforced expression of miR-224-5p enhanced chemoresistance to cisplatin in ovarian cancer cells through apoptosis reversion. We predicted and identified the PRKCD gene as one of the targets of miR-224-5p in mediating the primary chemoresistance of ovarian cancer patients. We showed reciprocal expression of miR-224-5p and PRKCD by quantitative analysis in complete response and incomplete response patients in?vivo, and 2 pairs of cisplatin resistance and sensitive cell lines in?vitro, after either miR-224-5p overexpression or knockdown transfection. 1509 miR-23a hsa-miR-23a-3p,hsa-miR-23a-5p MIMAT0000078,MIMAT0004496 miRNA CASP3 apoptosis down Homo sapiens varian granulosa cells 22653319 9606 836 CPP32|CPP32B|SCA-1 HGNC:1504|MIM:600636|Ensembl:ENSG00000164305|HPRD:02799|Vega:OTTHUMG00000133681 4 4q34 caspase 3, apoptosis-related cysteine peptidase protein-coding caspase 3, apoptosis-related cysteine peptidase A decrease in XIAP expression (mRNA and protein level) and caspase-3 protein levels and an increase in cleaved caspase-3 protein were observed in human ovarian granulosa cells transfected with pre-mir-23a, along with an increased occurrence of apoptosis. 1510 miR-23a hsa-miR-23a-3p,hsa-miR-23a-5p MIMAT0000078,MIMAT0004496 miRNA CASP7 apoptosis down Homo sapiens UVB-irradiated HaCaT cell 23158364 9606 840 CASP-7|CMH-1|ICE-LAP3|LICE2|MCH3 HGNC:1508|MIM:601761|Ensembl:ENSG00000165806|HPRD:03457|Vega:OTTHUMG00000019076 10 10q25 caspase 7, apoptosis-related cysteine peptidase protein-coding caspase 7, apoptosis-related cysteine peptidase Forced over-expression of miR-23a decreased the expression of UVB-induced topoisomerase-1caspase7STK4 at both the mRNA and protein levels, and these effects were reversed by down-regulation of miR-23a. 1511 miR-23a hsa-miR-23a-5p,hsa-miR-23a-3p MIMAT0004496,MIMAT0000078 miRNA XIAP apoptosis up Homo sapiens ischemic brain 21709246 9606 331 API3|BIRC4|IAP-3|ILP1|MIHA|XLP2|hIAP-3|hIAP3 HGNC:592|MIM:300079|Ensembl:ENSG00000101966|HPRD:02094|Vega:OTTHUMG00000022336 X Xq25 X-linked inhibitor of apoptosis protein-coding X-linked inhibitor of apoptosis E3 ubiquitin-protein liga XIAP is a previously uncharacterized target for miR 23a. miR-23a levels differed in male and female ischemic brains, providing evidence for sex specific miRNA expression in stroke. 1512 miR-23a hsa-miR-23a-3p,hsa-miR-23a-5p MIMAT0000078,MIMAT0004496 miRNA XIAP apoptosis down Homo sapiens varian granulosa cells 22653319 9606 331 API3|BIRC4|IAP-3|ILP1|MIHA|XLP2|hIAP-3|hIAP3 HGNC:592|MIM:300079|Ensembl:ENSG00000101966|HPRD:02094|Vega:OTTHUMG00000022336 X Xq25 X-linked inhibitor of apoptosis protein-coding X-linked inhibitor of apoptosis A decrease in XIAP expression (mRNA and protein level) and caspase-3 protein levels and an increase in cleaved caspase-3 protein were observed in human ovarian granulosa cells transfected with pre-mir-23a, along with an increased occurrence of apoptosis. 1513 miR-23b hsa-miR-23b-3p,hsa-miR-23b-5p MIMAT0000418,MIMAT0004587 miRNA AKT1 apoptosis up Homo sapiens prostate cancer cells 23074286 9606 207 AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA HGNC:391|MIM:164730|Ensembl:ENSG00000142208|HPRD:01261|Vega:OTTHUMG00000170795 14 14q32.32 v-akt murine thymoma viral oncogene homolog 1 protein-coding v-akt murine thymoma viral oncogene homolog 1 Increased expression of miR-23b inhibited proliferation, colony formation, migration/invasion, and triggered G(0)-G(1) cell-cycle arrest and apoptosis in prostate cancer. 1514 miR-23b hsa-miR-23b-5p,hsa-miR-23b-3p MIMAT0004587,MIMAT0000418 miRNA PRODH apoptosis down Homo sapiens renal cancer cells 20562915 9606 5625 HSPOX2|PIG6|POX|PRODH1|PRODH2|TP53I6 HGNC:9453|MIM:606810|Ensembl:ENSG00000100033|HPRD:08433|Vega:OTTHUMG00000150163 22 22q11.21 proline dehydrogenase (oxidase) 1 protein-coding proline dehydrogenase (oxidase) 1 p53-induced gene 6 protei Ectopic overexpression of miR-23b in normal renal cells resulted in striking downregulation of POX, whereas POX expression increased markedly when endogenous miR-23b was knocked down by its antagomirs in renal cancer cells. Consistent with the POX-mediated tumor suppression pathway, these antagomirs induced ROS, inhibited HIF signaling and increased apoptosis. 1515 miR-23b hsa-miR-23b-3p,hsa-miR-23b-5p MIMAT0000418,MIMAT0004587 miRNA SRC apoptosis up Homo sapiens prostate cancer cells 23074286 9606 6714 ASV|SRC1|c-SRC|p60-Src HGNC:11283|MIM:190090|Ensembl:ENSG00000197122|HPRD:01819|Vega:OTTHUMG00000032417 20 20q12-q13 SRC proto-oncogene, non-receptor tyrosine kinase protein-coding SRC proto-oncogene, non-receptor tyrosine kinase Increased expression of miR-23b inhibited proliferation, colony formation, migration/invasion, and triggered G(0)-G(1) cell-cycle arrest and apoptosis in prostate cancer. 1516 miR-23b hsa-miR-23b-3p,hsa-miR-23b-5p MIMAT0000418,MIMAT0004587 miRNA ZEB1 apoptosis down Homo sapiens bladder cancer cell lines and tumor cells 23844063 9606 6935 AREB6|BZP|DELTAEF1|FECD6|NIL2A|PPCD3|TCF8|ZFHEP|ZFHX1A HGNC:11642|MIM:189909|Ensembl:ENSG00000148516|HPRD:01798|Vega:OTTHUMG00000017907 10 10p11.2 zinc finger E-box binding homeobox 1 protein-coding zinc finger E-box binding homeobox 1 Fluorescence activated cell sorting (FACS) analysis revealed that re-expression of miR-23b in bladder cancer cells induced G0/G1 cell cycle arrest and apoptosis while inhibiting cell migration and invasion. Luciferase reporter assays demonstrated that Zeb1, a crucial regulator of epithelial-to-mesenchymal transition (EMT), is a direct target of miR-23b in bladder cancer. 1517 miR-23b hsa-miR-23b-3p,hsa-miR-23b-5p MIMAT0000418,MIMAT0004587 miRNA apoptosis Homo sapiens glioma cells 22649212 9606 7428 RCA1|VHL1|pVHL|HRCA1 HGNC:12687|HPRD:01905|MIM:608537 3 3p25.3 von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase protein coding von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase Down-regulation of miR-23b triggered growth inhibition, induced apoptosis, and suppressed invasion of glioma in vitro. 1518 miR-24 hsa-miR-24-1-5p,hsa-miR-24-2-5p,hsa-miR-24-3p MIMAT0000079,MIMAT0004497,MIMAT0000080 miRNA BCL2 apoptosis down Homo sapiens breast cancer cells 22328513 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 apoptosis regulator Bcl-2 Ectopic expression of miR-195, miR-24-2 and miR-365-2 individually led to a significant reduction of the levels of BCL2 protein. 1519 miR-24 hsa-miR-24-1-5p,hsa-miR-24-3p,hsa-miR-24-2-5p MIMAT0000079,MIMAT0000080,MIMAT0004497 miRNA XIAP apoptosis down Homo sapiens cancer 22733138 9606 331 API3|BIRC4|IAP-3|ILP1|MIHA|XLP2|hIAP-3|hIAP3 HGNC:592|MIM:300079|Ensembl:ENSG00000101966|HPRD:02094|Vega:OTTHUMG00000022336 X Xq25 X-linked inhibitor of apoptosis protein-coding X-linked inhibitor of apoptosis Moreover, miR-24 overexpression can overcome apoptosis resistance in cancer cells via downregulation of XIAP expression, and the resulting cancer cell death induced by tumor necrosis factor-related apoptosis-inducing ligand is executed by the canonical caspase-mediated apoptosis pathway. 1520 miR-24 hsa-miR-24-1-5p,hsa-miR-24-3p,hsa-miR-24-2-5p MIMAT0000079,MIMAT0000080,MIMAT0004497 miRNA apoptosis Homo sapiens nasopharyngeal carcinoma?cell 25319395 9606 We found that miR24 inhibited NPC cell growth, promoted cell apoptosis, and suppressed the growth of NPC xenografts. We showed that miR24 was significantly downregulated in recurrent NPC tissues. 1521 miR-25 hsa-miR-25-5p,hsa-miR-25-3p MIMAT0004498,MIMAT0000081 miRNA E2F1 apoptosis down Homo sapiens gastric cancer cells 18328430 9606 1869 E2F-1|RBAP1|RBBP3|RBP3 HGNC:3113|MIM:189971|Ensembl:ENSG00000101412|HPRD:01806|Vega:OTTHUMG00000032265 20 20q11.2 E2F transcription factor 1 protein-coding E2F transcription factor 1 Here we provide evidence that the miR-106b-25 cluster, upregulated in a subset of human gastric tumors, is activated by E2F1 in parallel with its host gene, Mcm7. In turn, miR-106b and miR-93 regulate E2F1 expression, establishing a miRNA-directed negative feedback loop. Furthermore, upregulation of these miRNAs impairs the TGFbeta tumor suppressor pathway, interfering with the expression of CDKN1A (p21(Waf1/Cip1)) and BCL2L11 (Bim). 1522 miR-25 hsa-miR-25-3p,hsa-miR-25-5p MIMAT0004498,MIMAT0000081 miRNA RECK apoptosis down Homo sapiens Gastric 24078004 9606 8434 ST15 HGNC:11345|MIM:605227|Ensembl:ENSG00000122707|HPRD:05567|Vega:OTTHUMG00000019898 9 9p13.3 reversion-inducing-cysteine-rich protein with kazal motifs protein-coding reversion-inducing-cysteine-rich protein with kazal motifs Finally, reversion-inducing-cysteine-rich protein with kazal motifs (RECK) was found to be a target of miR-25. Overexpression of RECK could significantly reverse the oncogenic effect of miR-25. Taken together, miR-25 might promote GC cells growth and motility partially by targeting RECK. 1523 miR-26 hsa-miR-26a-5p,hsa-miR-26a-1-3p,hsa-miR-26b-5p,hsa-miR-26b-3p MIMAT0000082,MIMAT0004499,MIMAT0004500,MIMAT0000083 miRNA apoptosis Homo sapiens 22848262 9606 MiR-26, a functional miRNA, has received much attention from researchers in recent years. miRNAs may play crucial roles in numerous biological processes such as cell proliferation, apoptosis, tumorigenesis at different stages of non-tumor diseases, growth and development of normal tissues, and other biological processes. The expression of miR-26 has been found to be specific to different biological processes. Furthermore, its expression is frequently abnormal in tumors, indicating that miR-26 may play significant roles in tumor formation. Various reports exist regarding miR-26 involvement in non-tumor diseases, as well as the process of growth and development of normal tissues. In this review, we report findings of recent studies on the expression of miR-26 in different types of diseases and the process of growth and development and its predicted target genes in different tissue types. In conclusion, it is useful for researchers to understand the role of miR-26 in different biological processes. 1524 miR-26a hsa-miR-26a-5p,hsa-miR-26a-1-3p,hsa-miR-26a-2-3p MIMAT0000082,MIMAT0004499,MIMAT0004681 miRNA CHEK1 apoptosis down Homo sapiens breast| prostate 24336073 9606 1111 CHK1 HGNC:1925|MIM:603078|Ensembl:ENSG00000149554|HPRD:04356|Vega:OTTHUMG00000165853 11 11q24.2 checkpoint kinase 1 protein-coding checkpoint kinase 1 Collectively, our data provide a novel mechanism whereby p53 represses Chk1 and Wee1 expression, at least partially, via upregulation of miR-16 and miR-26a and thus sensitizes tumour cells to genotoxic therapies. 1525 miR-26a hsa-miR-26a-5p,hsa-miR-26a-1-3p MIMAT0000082,MIMAT0004499 miRNA SMAD1 apoptosis down Homo sapiens Aberrant smooth muscle cell 20857419 9606 4086 BSP-1|BSP1|JV4-1|JV41|MADH1|MADR1 HGNC:6767|MIM:601595|Ensembl:ENSG00000170365|HPRD:03356|Vega:OTTHUMG00000161592 4 4q31 SMAD family member 1 protein-coding SMAD family member 1 Dual-luciferase reporter assays demonstrated enhanced SMAD signaling with miRNA-26a inhibition, and the opposite effect with miRNA-26a overexpression in transfected human cells. Furthermore, inhibition of miRNA-26a increased gene expression of SMAD-1 and SMAD-4, while overexpression inhibited SMAD-1 1526 miR-26a hsa-miR-26a-5p,hsa-miR-26a-1-3p MIMAT0000082,MIMAT0004499 miRNA SMAD4 apoptosis down Homo sapiens Aberrant smooth muscle cell 20857419 9606 4089 DPC4|JIP|MADH4|MYHRS HGNC:6770|MIM:600993|Ensembl:ENSG00000141646|HPRD:02995|Vega:OTTHUMG00000132696 18 18q21.1 SMAD family member 4 protein-coding SMAD family member 4 Dual-luciferase reporter assays demonstrated enhanced SMAD signaling with miRNA-26a inhibition, and the opposite effect with miRNA-26a overexpression in transfected human cells. Furthermore, inhibition of miRNA-26a increased gene expression of SMAD-1 and SMAD-4, while overexpression inhibited SMAD-1 1527 miR-26a hsa-miR-26a-5p,hsa-miR-26a-1-3p MIMAT0000082,MIMAT0004499 miRNA TNFSF10 apoptosis down Homo sapiens NA 20230625 9606 8743 APO2L|Apo-2L|CD253|TL2|TRAIL HGNC:11925|MIM:603598|Ensembl:ENSG00000121858|HPRD:04670|Vega:OTTHUMG00000156917 3 3q26 tumor necrosis factor (ligand) superfamily, member 10 protein-coding tumor necrosis factor (ligand) superfamily, member 10 Transfection of mimics of miR-26a protects several cell types from TRAIL-induced cell death. 1528 miR-26a hsa-miR-26a-5p,hsa-miR-26a-1-3p MIMAT0000082,MIMAT0004499 miRNA apoptosis Homo sapiens biliary cell 19345069 9606 Quantitative PCR was employed to validate down-regulation of microRNA-122a (miR-122a) and miR-26a and the increased expression of miR-328 and miR-299-5p. The predicted targets of these miRNAs are known to affect cell proliferation, apoptosis, inflammation, oxidative stress, and metabolism. Our data are the first to demonstrate that PBC is characterized by altered expression of hepatic miRNA; however additional studies are required to demonstrate a causal link between those miRNA and the development of PBC. 1529 miR-26b hsa-miR-26b-5p,hsa-miR-26b-3p MIMAT0000083,MIMAT0004500 miRNA apoptosis down Homo sapiens hepatocellular carcinoma cell 24565101 9606 257397 NAP1|MAP3K7IP3 HGNC:30681|Ensembl:ENSG00000157625|HPRD:06738|MIM:300480|Vega:OTTHUMG00000021329 x Xp21.2 TGF-beta activated kinase 1|MAP3K7 binding protein 3 protein coding TGF-beta activated kinase 1|MAP3K7 binding protein 3 Subsequent investigations revealed that miR-26b inhibited the expression of TAK1 and TAB3, two positive regulators of NF-¦ÊB pathway, by binding to their 3'-untranslated region. 1530 miR-27 hsa-miR-27a-3p,hsa-miR-27a-5p,hsa-miR-27b-5p,hsa-miR-27b-3p MIMAT0000084,MIMAT0004501,MIMAT0004588,MIMAT0000419 miRNA FOXO1 apoptosis Homo sapiens endometrial adenocarcinoma 24746199 9606 2308 FKH1|FKHR|FOXO1A HGNC:3819|MIM:136533|Ensembl:ENSG00000150907|HPRD:00645|Vega:OTTHUMG00000016775 13 13q14.1 forkhead box O1 protein-coding forkhead box O1 In conclusion, we propose that the miR27-FOXO1 tandem inhibits apoptosis and represents an alternative pathway for tumor cell survival in PIK3CA-nonmutated EEC. 1531 miR-27a hsa-miR-27a-3p,hsa-miR-27a-5p MIMAT0000084,MIMAT0004501 miRNA ZBTB10 apoptosis down Homo sapiens MDA-MB-231 cell 22407812 9606 65986 RINZF HGNC:30953|Ensembl:ENSG00000205189|HPRD:15689|Vega:OTTHUMG00000155016 8 8q13-q21.1 zinc finger and BTB domain containing 10 protein-coding zinc finger and BTB domain containing 10 The BA-induced Sp1, Sp3, and Sp4 downregulation was accompanied by increased zinc finger ZBTB10 expression, a putative Sp-repressor and decreased microRNA-27a levels, a microRNA involved in the regulation of ZBTB10. 1532 miR-27a hsa-miR-27a-3p,hsa-miR-27a-5p MIMAT0000084,MIMAT0004501 miRNA ZBTB10 apoptosis down Homo sapiens colon cancer cells 23194063 9606 65986 RINZF HGNC:30953|Ensembl:ENSG00000205189|HPRD:15689|Vega:OTTHUMG00000155016 8 8q13-q21.1 zinc finger and BTB domain containing 10 protein-coding zinc finger and BTB domain containing 10 Curcumin and RL197 inhibited RKO and SW480 colon cancer cell growth and induced apoptosis,The mechanism of curcumin-/RL197-induced repression of Sp transcription factors was ROS-dependent and due to induction of the Sp repressors ZBTB10 and ZBTB4 and downregulation of microRNAs (miR)-27a, miR-20a and miR-17-5p that regulate these repressors. 1533 miR-27a hsa-miR-27a-3p,hsa-miR-27a-5p MIMAT0000084,MIMAT0004501 miRNA ZBTB4 apoptosis down Homo sapiens colon cancer cells 23194063 9606 57659 KAISO-L1|ZNF903 HGNC:23847|MIM:612308|Ensembl:ENSG00000174282|HPRD:11693|Vega:OTTHUMG00000108137 17 17p13.1 zinc finger and BTB domain containing 4 protein-coding zinc finger and BTB domain containing 4 Curcumin and RL197 inhibited RKO and SW480 colon cancer cell growth and induced apoptosis,The mechanism of curcumin-/RL197-induced repression of Sp transcription factors was ROS-dependent and due to induction of the Sp repressors ZBTB10 and ZBTB4 and downregulation of microRNAs (miR)-27a, miR-20a and miR-17-5p that regulate these repressors. 1534 miR-27b hsa-miR-27b-5p,hsa-miR-27b-3p MIMAT0004588,MIMAT0000419 miRNA CYP1B1 apoptosis down Homo sapiens cancer cells 25698578 9606 1545 CP1B|CYPIB1|GLC3A|P4501B1 HGNC:2597|MIM:601771|Ensembl:ENSG00000138061|HPRD:03464|Vega:OTTHUMG00000100970 2 2p22.2 cytochrome P450, family 1, subfamily B, polypeptide 1 protein-coding cytochrome P450, family 1, subfamily B, polypeptide 1 cytochrome P450, family 1, subfamily B, polypeptide 1 Functionally, miR-27b enhances drug response by activating p53-dependent apoptosis and reducing CYP1B1-mediated drug detoxification. 1535 miR-29 hsa-miR-29a-3p,hsa-miR-29b-3p,hsa-miR-29c-3p,hsa-miR-29a-5p,hsa-miR-29 MIMAT0000086 ,MIMAT0000100,MIMAT0000681,MIMAT00045 miRNA BCL2 apoptosis down Homo sapiens hepatocellular carcinoma cells 20041405 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 apoptosis regulator Bcl-2 Moreover, introduction of miR-29 dramatically repressed the ability of HCC cells to form tumor in nude mice. Subsequent investigation characterized two antiapoptotic molecules, Bcl-2 and Mcl-1, as direct targets of miR-29. Furthermore, silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29, whereas overexpression of these proteins attenuated the effect of miR-29. 1536 miR-29 hsa-miR-29a-3p,hsa-miR-29b-3p,hsa-miR-29c-3p,hsa-miR-29a-5p,hsa-miR-29 MIMAT0000086 ,MIMAT0000100,MIMAT0000681,MIMAT00045 miRNA CDC42 apoptosis down Homo sapiens p53-positive breast cancer cells 19079265 9606 998 CDC42Hs|G25K HGNC:1736|MIM:116952|Ensembl:ENSG00000070831|HPRD:00309|Vega:OTTHUMG00000002753 1 1p36.1 cell division cycle 42 protein-coding cell division cycle 42 G25K GTP-binding protein| MiR-29 family members (miR-29a, miR-29b and miR-29c) upregulate p53 levels and induce apoptosis in a p53-dependent manner and directly suppress p85 alpha (the regulatory subunit of PI3 kinase) and CDC42 (a Rho family GTPase), both of which negatively regulate p53. 1537 miR-29 hsa-miR-29a-3p,hsa-miR-29b-3p,hsa-miR-29c-3p,hsa-miR-29a-5p,hsa-miR-29 MIMAT0000086 ,MIMAT0000100,MIMAT0000681,MIMAT00045 miRNA CDK6 apoptosis Homo sapiens HPV-infected cell 21503900 9606 1021 PLSTIRE HGNC:1777|MIM:603368|Ensembl:ENSG00000105810|HPRD:04533|Vega:OTTHUMG00000131697 7 7q21-q22 cyclin-dependent kinase 6 protein-coding cyclin-dependent kinase 6 miR-29 restrains cell cycle progression and induces apoptosis via YY1 and CDK6 promoting malignant transformation induced by HPV, although the abnormality of miR-29 in HPV-infected cells might be regulated in an indirect way. 1538 miR-29 hsa-miR-29a-3p,hsa-miR-29b-3p,hsa-miR-29c-3p,hsa-miR-29a-5p,hsa-miR-29 MIMAT0000086 ,MIMAT0000100,MIMAT0000681,MIMAT00045 miRNA DNMT3A apoptosis down Homo sapiens 20643754 9606 1788 DNMT3A2|M.HsaIIIA|TBRS HGNC:2978|MIM:602769|Ensembl:ENSG00000119772|HPRD:04141|Vega:OTTHUMG00000094777 2 2p23 DNA (cytosine-5-)-methyltransferase 3 alpha protein-coding DNA (cytosine-5-)-methyltransferase 3 alpha Upregulation of the miR-29 family resulted in decreased levels of its targets DNMT3a and MCL1, consequently affecting DNA methylation and apoptosis. Altered expression of miR-16 led to changes in expression of BCL2, suggesting modulation of apoptosis. 1539 miR-29 hsa-miR-29a-3p,hsa-miR-29b-3p,hsa-miR-29c-3p,hsa-miR-29a-5p,hsa-miR-29 MIMAT0000086 ,MIMAT0000100,MIMAT0000681,MIMAT00045 miRNA MCL1 apoptosis down Homo sapiens hepatocellular carcinoma cells 20041405 9606 4170 BCL2L3|EAT|MCL1-ES|MCL1L|MCL1S|Mcl-1|TM|bcl2-L-3|mcl1/EAT HGNC:6943|MIM:159552|Ensembl:ENSG00000143384|HPRD:08870|Vega:OTTHUMG00000034867 1 1q21 myeloid cell leukemia 1 protein-coding myeloid cell leukemia 1 apoptosis regulator Bcl-2 Moreover, introduction of miR-29 dramatically repressed the ability of HCC cells to form tumor in nude mice. Subsequent investigation characterized two antiapoptotic molecules, Bcl-2 and Mcl-1, as direct targets of miR-29. Furthermore, silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29, whereas overexpression of these proteins attenuated the effect of miR-29. 1540 miR-29 hsa-miR-29a-3p,hsa-miR-29b-3p,hsa-miR-29c-3p,hsa-miR-29a-5p,hsa-miR-29 MIMAT0000086 ,MIMAT0000100,MIMAT0000681,MIMAT00045 miRNA MCL1 apoptosis down Homo sapiens 20643754 9606 4170 BCL2L3|EAT|MCL1-ES|MCL1L|MCL1S|Mcl-1|TM|bcl2-L-3|mcl1/EAT HGNC:6943|MIM:159552|Ensembl:ENSG00000143384|HPRD:08870|Vega:OTTHUMG00000034867 1 1q21 myeloid cell leukemia 1 protein-coding myeloid cell leukemia 1 Upregulation of the miR-29 family resulted in decreased levels of its targets DNMT3a and MCL1, consequently affecting DNA methylation and apoptosis. Altered expression of miR-16 led to changes in expression of BCL2, suggesting modulation of apoptosis. 1541 miR-29 hsa-miR-29a-3p,hsa-miR-29b-3p,hsa-miR-29c-3p,hsa-miR-29a-5p,hsa-miR-29 MIMAT0000086 ,MIMAT0000100,MIMAT0000681,MIMAT00045 miRNA PIK3R1 apoptosis down Homo sapiens p53-positive breast cancer cells 19079265 9606 5295 AGM7|GRB1|p85|p85-ALPHA HGNC:8979|MIM:171833|Ensembl:ENSG00000145675|HPRD:01381|Vega:OTTHUMG00000131251 5 5q13.1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) protein-coding phosphoinositide-3-kinase, regulatory subunit 1 (alpha) G25K GTP-binding protein| MiR-29 family members (miR-29a, miR-29b and miR-29c) upregulate p53 levels and induce apoptosis in a p53-dependent manner and directly suppress p85 alpha (the regulatory subunit of PI3 kinase) and CDC42 (a Rho family GTPase), both of which negatively regulate p53. 1542 miR-29 hsa-miR-29a-3p,hsa-miR-29b-3p,hsa-miR-29c-3p,hsa-miR-29a-5p,hsa-miR-29 MIMAT0000086 ,MIMAT0000100,MIMAT0000681,MIMAT00045 miRNA TP53 apoptosis up Homo sapiens p53-positive breast cancer cells 19079265 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 G25K GTP-binding protein| MiR-29 family members (miR-29a, miR-29b and miR-29c) upregulate p53 levels and induce apoptosis in a p53-dependent manner and directly suppress p85 alpha (the regulatory subunit of PI3 kinase) and CDC42 (a Rho family GTPase), both of which negatively regulate p53. 1543 miR-29 hsa-miR-29a-3p,hsa-miR-29b-3p,hsa-miR-29c-3p,hsa-miR-29a-5p,hsa-miR-29 MIMAT0000086 ,MIMAT0000100,MIMAT0000681,MIMAT00045 miRNA TP53 apoptosis updown Homo sapiens 22248053 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 YY1 inhibits the expression of both miR-29 and miR-206.70,71 These 2 miRs possess tumor-suppressive activities through activating p53 and promoting cell apoptosis, respectively 1544 miR-29 hsa-miR-29a-3p,hsa-miR-29b-3p,hsa-miR-29c-3p,hsa-miR-29a-5p,hsa-miR-29 MIMAT0000086 ,MIMAT0000100,MIMAT0000681,MIMAT00045 miRNA YY1 apoptosis Homo sapiens HPV-infected cell 21503900 9606 7528 DELTA|INO80S|NF-E1|UCRBP|YIN-YANG-1 HGNC:12856|MIM:600013|HPRD:02482 14 14q YY1 transcription factor protein-coding YY1 transcription factor miR-29 restrains cell cycle progression and induces apoptosis via YY1 and CDK6 promoting malignant transformation induced by HPV, although the abnormality of miR-29 in HPV-infected cells might be regulated in an indirect way. 1545 miR-29 hsa-miR-29a-3p,hsa-miR-29b-3p,hsa-miR-29c-3p,hsa-miR-29a-5p,hsa-miR-29 MIMAT0000086 ,MIMAT0000100,MIMAT0000681,MIMAT00045 miRNA apoptosis Homo sapiens atrial cell 23595377 9606 Samples of a trial tissue showed the abnormal pathohistological and ultrastructural changes, the accelerated fibrosis, and apoptosis with aging and/or in AF dogs. Compared to the adult group, the expressions of microRNAs-21 and -29 were significantly increased, whereas the expressions of microRNAs-1 and -133 showed obvious downregulation tendency in the aged group. 1546 miR-29 hsa-miR-29a-3p,hsa-miR-29b-3p,hsa-miR-29c-3p,hsa-miR-29a-5p,hsa-miR-29 MIMAT0000086 ,MIMAT0000100,MIMAT0000681,MIMAT00045 miRNA apoptosis Homo sapiens breast/colon cancer cell 24573597 9606 We next highlight the upstream regulatory pathway of miR-29 and describe the relationship between miR-29 and cancer in detail. As a tumor suppressor, miR-29 restrains cancer progression by promoting tumor cell apoptosis, by suppressing DNA methylation of tumor-suppressor genes, by reducing proliferation of tumors and by increasing chemosensitivity. However, as a tumor promoter, miR-29 mediates epithelial-mesenchymal transition (EMT) and promotes metastasis in breast cancer and colon cancer. Finally, we suggest that miR-29 represents a novel diagnostic and prognostic biomarker or a therapeutic target for cancer. 1547 miR-2909 hsa-miR-2909 MIMAT0013863 miRNA KLF4 apoptosis Homo sapiens T cell 25037230 9606 9314 EZF|GKLF HGNC:6348|MIM:602253|Ensembl:ENSG00000136826|Vega:OTTHUMG00000020449 9 9q31 Kruppel-like factor 4 (gut) protein-coding Kruppel-like factor 4 (gut) Moreover, the inability of miR-2909 to regulate KLF4 and its downstream genes controlling cell cycle and apoptosis in T-cell but not in B-ALL was verified by antagomiR-2909 transfection. 1548 miR-296 hsa-miR-296-3p,hsa-miR-296-5p MIMAT0000690,MIMAT0004679 miRNA ABCB1 apoptosis up Homo sapiens esophageal squamous cell 20485139 9606 5243 ABC20|CD243|CLCS|GP170|MDR1|P-GP|PGY1 HGNC:40|MIM:171050|Ensembl:ENSG00000085563|HPRD:01370|Vega:OTTHUMG00000023393 7 7q21.12 ATP-binding cassette, sub-family B (MDR/TAP), member 1 protein-coding ATP-binding cassette, sub-family B (MDR/TAP), member 1 MiR-296 could confer sensitivity of both P-glycoprotein-related and P-glycoprotein-nonrelated drugs on esophageal cancer cells, and might promote ADR-induced apoptosis, accompanied by increased accumulation and decreased releasing amount of ADR. Downregulation of miR-296 could significantly decrease the expression of P-glycoprotein, Bcl-2, and the transcription of MDR1, but up-regulate the expression of Bax. 1549 miR-296 hsa-miR-296-3p,hsa-miR-296-5p MIMAT0000690,MIMAT0004679 miRNA BAX apoptosis down Homo sapiens esophageal squamous cell 20485139 9606 581 BCL2L4 HGNC:959|MIM:600040|Ensembl:ENSG00000087088|HPRD:02498|Vega:OTTHUMG00000160476 19 19q13.3-q13.4 BCL2-associated X protein protein-coding BCL2-associated X protein MiR-296 could confer sensitivity of both P-glycoprotein-related and P-glycoprotein-nonrelated drugs on esophageal cancer cells, and might promote ADR-induced apoptosis, accompanied by increased accumulation and decreased releasing amount of ADR. Downregulation of miR-296 could significantly decrease the expression of P-glycoprotein, Bcl-2, and the transcription of MDR1, but up-regulate the expression of Bax. 1550 miR-296 hsa-miR-296-3p,hsa-miR-296-5p MIMAT0000690,MIMAT0004679 miRNA BCL2 apoptosis up Homo sapiens esophageal squamous cell 20485139 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 MiR-296 could confer sensitivity of both P-glycoprotein-related and P-glycoprotein-nonrelated drugs on esophageal cancer cells, and might promote ADR-induced apoptosis, accompanied by increased accumulation and decreased releasing amount of ADR. Downregulation of miR-296 could significantly decrease the expression of P-glycoprotein, Bcl-2, and the transcription of MDR1, but up-regulate the expression of Bax. 1551 miR-296 hsa-miR-296-3p,hsa-miR-296-5p MIMAT0000690,MIMAT0004679 miRNA apoptosis Homo sapiens HeLa cells 15741182 9606 We also identified miRNA that when inhibited increased the level of apoptosis (miR-1d, 7, 148, 204, 210, 216 and 296) and one miRNA that decreased apoptosis (miR-214) in HeLa cells. 1552 miR-296-5p hsa-miR-296-5p MIMAT0000690 miRNA BBC3 apoptosis down Homo sapiens 21633093 9606 27113 JFY-1|JFY1|PUMA HGNC:17868|MIM:605854|Ensembl:ENSG00000105327|HPRD:16165|Vega:OTTHUMG00000183489 19 19q13.3-q13.4 BCL2 binding component 3 protein-coding BCL2 binding component 3 Also miR-296-5p levels inversely varied with PUMA mRNA levels in human liver specimens. Our results implicate miR-296-5p in the regulation of PUMA expression during hepatic lipoapoptosis. 1553 miR-296-5p hsa-miR-296-5p MIMAT0000690 miRNA CASP3 apoptosis Homo sapiens temporal lobe 24751812 9606 836 CPP32|CPP32B|SCA-1 HGNC:1504|MIM:600636|Ensembl:ENSG00000164305|HPRD:02799|Vega:OTTHUMG00000133681 4 4q34 caspase 3, apoptosis-related cysteine peptidase protein-coding caspase 3, apoptosis-related cysteine peptidase Meanwhile, the levels of miR-423-3p and miR-296-5p were correlated with the activity of caspase-3, an apoptosis indicator. Additionally, the loading of miR-423-3p was increased in RNA-induced silencing complex whilst caspase-6, a target of miR-423-3p, was reduced in chronic TLE rats. Collectively, our findings suggest that miRNAs may exert anti-apoptotic effects in chronic TLE. 1554 miR-296-5p hsa-miR-296-5p MIMAT0000690 miRNA CDX1 apoptosis down Homo sapiens gastric cancer cell 23353818 9606 1044 - HGNC:1805|MIM:600746|Ensembl:ENSG00000113722|HPRD:02849|Vega:OTTHUMG00000169772 5 5q32 caudal type homeobox 1 protein-coding caudal type homeobox 1 Furthermore, we found that the extracellular signal-regulated kinases 1 and 2 (ERK1/2) activation and the subsequent downstream changes in protein levels related to cell cycle and apoptosis partly account for the miR-296-5p-CDX1-induced GC growth promotion. In addition, the detection of miR-296-5p and expression of CDX1 in primary GC tissues and adjacent IM tissues revealed that miR-296-5p is inversely correlated with CDX1, further supporting our in vitro results. 1555 miR-298-5p hsa-miR-298 MIMAT0004901 miRNA IGF1R apoptosis down Homo sapiens mammalian pancreatic Ï« cell 23360399 9606 3480 CD221|IGFIR|IGFR|JTK13 HGNC:5465|MIM:147370|Ensembl:ENSG00000140443|HPRD:00932|Vega:OTTHUMG00000149851 15 15q26.3 insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor Altogether, high-throughput microRNA profiling, functional analysis with synthetic mimics and molecular characterization of modulated pathways strongly suggest that specific downregulation of miR-296-3p and miR-298-5p, coupled to upregulation of their targets as IGF1R¦Â and TNF¦Á, is a major determinant of mammalian pancreatic ¦Á cells resistance to apoptosis induction by cytokines. 1556 miR-298-5p hsa-miR-298 MIMAT0004901 miRNA TNF apoptosis down Homo sapiens mammalian pancreatic Ï« cell 23360399 9606 7124 DIF|TNF-alpha|TNFA|TNFSF2 HGNC:11892|MIM:191160|Ensembl:ENSG00000232810|HPRD:01855|Vega:OTTHUMG00000031194 6 6p21.3 tumor necrosis factor protein-coding tumor necrosis factor Altogether, high-throughput microRNA profiling, functional analysis with synthetic mimics and molecular characterization of modulated pathways strongly suggest that specific downregulation of miR-296-3p and miR-298-5p, coupled to upregulation of their targets as IGF1R¦Â and TNF¦Á, is a major determinant of mammalian pancreatic ¦Á cells resistance to apoptosis induction by cytokines. 1557 miR-299-5p hsa-miR-299-5p MIMAT0002890 miRNA apoptosis Homo sapiens biliary cell 19345069 9606 Quantitative PCR was employed to validate down-regulation of microRNA-122a (miR-122a) and miR-26a and the increased expression of miR-328 and miR-299-5p. The predicted targets of these miRNAs are known to affect cell proliferation, apoptosis, inflammation, oxidative stress, and metabolism. Our data are the first to demonstrate that PBC is characterized by altered expression of hepatic miRNA; however additional studies are required to demonstrate a causal link between those miRNA and the development of PBC. 1558 miR-29a hsa-miR-29a-3p,hsa-miR-29a-5p MIMAT0000086,MIMAT0004503 miRNA BCL2 apoptosis down Homo sapiens H9c2 cells 20164119 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 In contrast, overexpressing miR-29 promoted apoptosis and completely blocked the protective effect of PIO. Antagomirs against miR-29a or -29c significantly reduced myocardial infarct size and apoptosis in hearts subjected to IR injury. Western blot analyses demonstrated that Mcl-2, an anti-apoptotic Bcl-2 family member, was increased by miR-29 inhibition. 1559 miR-29a hsa-miR-29a-3p,hsa-miR-29a-5p MIMAT0000086,MIMAT0004503 miRNA BCL2 apoptosis down Homo sapiens osteosarcoma cells 23113351 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 miRNA-29 members induced apoptosis through p53 gene activation, the effect of miRNA-29a on osteoblastic cells was independent on p53 expression level. Moreover, Bcl-2 and Mcl-1 were earlier demonstrated to be the direct targets of miRNA-29 in many types of cancer tissues and cancers. In addition, enhanced expression of miRNA-29a increased the expression of two tumor suppressor genes, E2F1 and E2F3. 1560 miR-29a hsa-miR-29a-3p,hsa-miR-29a-5p MIMAT0000086,MIMAT0004503 miRNA E2F1 apoptosis up Homo sapiens osteosarcoma cells 23113351 9606 1869 E2F-1|RBAP1|RBBP3|RBP3 HGNC:3113|MIM:189971|Ensembl:ENSG00000101412|HPRD:01806|Vega:OTTHUMG00000032265 20 20q11.2 E2F transcription factor 1 protein-coding E2F transcription factor 1 miRNA-29 members induced apoptosis through p53 gene activation, the effect of miRNA-29a on osteoblastic cells was independent on p53 expression level. Moreover, Bcl-2 and Mcl-1 were earlier demonstrated to be the direct targets of miRNA-29 in many types of cancer tissues and cancers. In addition, enhanced expression of miRNA-29a increased the expression of two tumor suppressor genes, E2F1 and E2F3. 1561 miR-29a hsa-miR-29a-3p,hsa-miR-29a-5p MIMAT0000086,MIMAT0004503 miRNA E2F3 apoptosis up Homo sapiens osteosarcoma cells 23113351 9606 1871 E2F-3 HGNC:3115|MIM:600427|Ensembl:ENSG00000112242|HPRD:02693|Vega:OTTHUMG00000016389 6 6p22 E2F transcription factor 3 protein-coding E2F transcription factor 3 miRNA-29 members induced apoptosis through p53 gene activation, the effect of miRNA-29a on osteoblastic cells was independent on p53 expression level. Moreover, Bcl-2 and Mcl-1 were earlier demonstrated to be the direct targets of miRNA-29 in many types of cancer tissues and cancers. In addition, enhanced expression of miRNA-29a increased the expression of two tumor suppressor genes, E2F1 and E2F3. 1562 miR-29a hsa-miR-29a-3p,hsa-miR-29a-5p MIMAT0000086,MIMAT0004503 miRNA MCL1 apoptosis down Homo sapiens H9c2 cells 20164119 9606 4170 BCL2L3|EAT|MCL1-ES|MCL1L|MCL1S|Mcl-1|TM|bcl2-L-3|mcl1/EAT HGNC:6943|MIM:159552|Ensembl:ENSG00000143384|HPRD:08870|Vega:OTTHUMG00000034867 1 1q21 myeloid cell leukemia 1 protein-coding myeloid cell leukemia 1 In contrast, overexpressing miR-29 promoted apoptosis and completely blocked the protective effect of PIO. Antagomirs against miR-29a or -29c significantly reduced myocardial infarct size and apoptosis in hearts subjected to IR injury. Western blot analyses demonstrated that Mcl-1, an anti-apoptotic Bcl-2 family member, was increased by miR-29 inhibition. 1563 miR-29a hsa-miR-29a-3p,hsa-miR-29a-5p MIMAT0000086,MIMAT0004503 miRNA MCL1 apoptosis down Homo sapiens osteosarcoma cells 23113351 9606 4170 BCL2L3|EAT|MCL1-ES|MCL1L|MCL1S|Mcl-1|TM|bcl2-L-3|mcl1/EAT HGNC:6943|MIM:159552|Ensembl:ENSG00000143384|HPRD:08870|Vega:OTTHUMG00000034867 1 1q21 myeloid cell leukemia 1 protein-coding myeloid cell leukemia 1 miRNA-29 members induced apoptosis through p53 gene activation, the effect of miRNA-29a on osteoblastic cells was independent on p53 expression level. Moreover, Bcl-2 and Mcl-1 were earlier demonstrated to be the direct targets of miRNA-29 in many types of cancer tissues and cancers. In addition, enhanced expression of miRNA-29a increased the expression of two tumor suppressor genes, E2F1 and E2F3. 1564 miR-29a hsa-miR-29a-3p,hsa-miR-29a-5p MIMAT0000086,MIMAT0004503 miRNA MCL1 apoptosis down Homo sapiens epithelial cells 25674218 9606 4170 BCL2L3|EAT|MCL1-ES|MCL1L|MCL1S|Mcl-1|TM|bcl2-L-3|mcl1/EAT HGNC:6943|MIM:159552|Ensembl:ENSG00000143384|HPRD:08870|Vega:OTTHUMG00000034867 1 1q21 myeloid cell leukemia 1 protein-coding myeloid cell leukemia 1 Knockout of Mcl-1 caused apoptosis of the colonic epithelial HT29 cells. In addition, miR-29a regulated intestinal epithelial apoptosis by down-regulating the expression of Mcl-1. 1565 miR-29a hsa-miR-29a-3p,hsa-miR-29a-5p MIMAT0000086,MIMAT0004503 miRNA PPM1D apoptosis Homo sapiens HepG-2 cell 21175813 9606 8493 PP2C-DELTA|WIP1 HGNC:9277|MIM:605100|HPRD:05482 17 17q23.2 protein phosphatase, Mg2+/Mn2+ dependent, 1D protein-coding protein phosphatase, Mg2+/Mn2+ dependent, 1D Among them, miR-29a showed a positive therapeutic effect in liver cancer cells by inhibiting cell growth and inducing cell apoptosis, and PPM1D was confirmed to be the target gene of miR-29a. Furthermore, a synergy effect was detected between miR-29a and arsenic trioxide. 1566 miR-29a hsa-miR-29a-3p,hsa-miR-29a-5p MIMAT0000086,MIMAT0004503 miRNA apoptosis down Homo sapiens glioma cell 24595468 9606 871 CBP1|CBP2|OI10|gp46|AsTP3|SERPINH1|PIG14|PPROM|RA-A47|SERPINH2 HGNC:1546|Ensembl:ENSG00000149257|HPRD:02968|MIM:600943|Vega:OTTHUMG00000165362 11 11q13.5 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) protein coding serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) he results suggested that the expression of HSP47 is regulated by miR-29a. Finally, stable knockdown of HSP47 using shRNA inhibits glioma tumor growth and induces apoptosis in mice models in vivo. Therefore, our data suggested that HSP47 regulated by miR-29a to enhance glioma tumor growth and invasion. 1567 miR-29b hsa-miR-29b-3p,hsa-miR-29b-1-5p,hsa-miR-29b-2-5p MIMAT0000100,MIMAT0004514,MIMAT0004515 miRNA ABL1 apoptosis down Homo sapiens CML patient samples 23428668 9606 25 ABL|JTK7|bcr/abl|c-ABL|c-ABL1|p150|v-abl HGNC:76|MIM:189980|Ensembl:ENSG00000097007|HPRD:01809|Vega:OTTHUMG00000020813 9 9q34.1 ABL proto-oncogene 1, non-receptor tyrosine kinase protein-coding ABL proto-oncogene 1, non-receptor tyrosine kinase miR-29b significantly suppresses the activity of a luciferase reporter containing ABL1-3'UTR and this activity is not observed in cells transfected with mutated ABL1-3'UTR. 1568 miR-29b hsa-miR-29b-3p,hsa-miR-29b-1-5p,hsa-miR-29b-2-5p MIMAT0000100,MIMAT0004514,MIMAT0004515 miRNA BCL2 apoptosis down Homo sapiens plasmacytoid dendritic cell 23894561 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Bioinformatics analysis and functional studies indicated that miR-29b and miR-29c were 2 key miRNAs involved in TLR-inhibited GC-induced pDC apoptosis. Furthermore, both of these miRNAs promoted pDC apoptosis by directly targeting Mcl-1 and Bcl-2 in human primary pDCs. Our findings provide new targets that could improve the efficacy of GCs for the treatment of SLE. 1569 miR-29b hsa-miR-29b-3p,hsa-miR-29b-1-5p,hsa-miR-29b-2-5p MIMAT0000100,MIMAT0004514,MIMAT0004515 miRNA ITGB1 apoptosis down Homo sapiens trophoblast cells 22716646 9606 3688 CD29|FNRB|GPIIA|MDF2|MSK12|VLA-BETA|VLAB HGNC:6153|MIM:135630|Ensembl:ENSG00000150093|HPRD:00628|Vega:OTTHUMG00000017928 10 10p11.2 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) protein-coding integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) We found that miR-29b induced apoptosis and inhibited invasion and angiogenesis of trophoblast cells. Further studies confirmed that miR-29b regulated the expression of MCL1 (myeloid cell leukaemia sequence 1), MMP2 (encoding matrix metallproteinase 2), VEGFA (vascular endothelial growth factor A) and ITGB1 (integrin ¦Â1) genes by directly binding to their 3'-UTRs (untranslated regions). Moreover, we identified that there was an inverse correlation between miR-29b and its target genes in subjects with PE. 1570 miR-29b hsa-miR-29b-3p,hsa-miR-29b-1-5p,hsa-miR-29b-2-5p MIMAT0000100,MIMAT0004514,MIMAT0004515 miRNA MCL1 apoptosis down Homo sapiens trophoblast cells 22716646 9606 4170 BCL2L3|EAT|MCL1-ES|MCL1L|MCL1S|Mcl-1|TM|bcl2-L-3|mcl1/EAT HGNC:6943|MIM:159552|Ensembl:ENSG00000143384|HPRD:08870|Vega:OTTHUMG00000034867 1 1q21 myeloid cell leukemia 1 protein-coding myeloid cell leukemia 1 We found that miR-29b induced apoptosis and inhibited invasion and angiogenesis of trophoblast cells. Further studies confirmed that miR-29b regulated the expression of MCL1 (myeloid cell leukaemia sequence 1), MMP2 (encoding matrix metallproteinase 2), VEGFA (vascular endothelial growth factor A) and ITGB1 (integrin ¦Â1) genes by directly binding to their 3'-UTRs (untranslated regions). Moreover, we identified that there was an inverse correlation between miR-29b and its target genes in subjects with PE. 1571 miR-29b hsa-miR-29b-3p,hsa-miR-29b-1-5p,hsa-miR-29b-2-5p MIMAT0000100,MIMAT0004514,MIMAT0004515 miRNA MCL1 apoptosis down Homo sapiens plasmacytoid dendritic cell 23894561 9606 4170 BCL2L3|EAT|MCL1-ES|MCL1L|MCL1S|Mcl-1|TM|bcl2-L-3|mcl1/EAT HGNC:6943|MIM:159552|Ensembl:ENSG00000143384|HPRD:08870|Vega:OTTHUMG00000034867 1 1q21 myeloid cell leukemia 1 protein-coding myeloid cell leukemia 1 Bioinformatics analysis and functional studies indicated that miR-29b and miR-29c were 2 key miRNAs involved in TLR-inhibited GC-induced pDC apoptosis. Furthermore, both of these miRNAs promoted pDC apoptosis by directly targeting Mcl-1 and Bcl-2 in human primary pDCs. Our findings provide new targets that could improve the efficacy of GCs for the treatment of SLE. 1572 miR-29b hsa-miR-29b-3p,hsa-miR-29b-1-5p,hsa-miR-29b-2-5p MIMAT0000100,MIMAT0004514,MIMAT0004515 miRNA MMP2 apoptosis down Homo sapiens trophoblast cells 22716646 9606 4313 CLG4|CLG4A|MMP-II|MONA|TBE-1 HGNC:7166|MIM:120360|Ensembl:ENSG00000087245|HPRD:00386|Vega:OTTHUMG00000133202 16 16q13-q21 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) protein-coding matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) We found that miR-29b induced apoptosis and inhibited invasion and angiogenesis of trophoblast cells. Further studies confirmed that miR-29b regulated the expression of MCL1 (myeloid cell leukaemia sequence 1), MMP2 (encoding matrix metallproteinase 2), VEGFA (vascular endothelial growth factor A) and ITGB1 (integrin ¦Â1) genes by directly binding to their 3'-UTRs (untranslated regions). Moreover, we identified that there was an inverse correlation between miR-29b and its target genes in subjects with PE. 1573 miR-29b hsa-miR-29b-3p,hsa-miR-29b-1-5p,hsa-miR-29b-2-5p MIMAT0000100,MIMAT0004514,MIMAT0004515 miRNA SP1 apoptosis up Homo sapiens multiple myeloma cells 23190608 9606 6667 - HGNC:11205|MIM:189906|Ensembl:ENSG00000185591|HPRD:01796|Vega:OTTHUMG00000170047 12 12q13.1 Sp1 transcription factor protein-coding Sp1 transcription factor MicroRNAs (miRNAs) with tumor-suppressor potential might have therapeutic applications in multiple myeloma (MM) through the modulation of still undiscovered molecular pathways. We identified Sp1, a transcription factor endowed with oncogenic activity, as a negative regulator of miR-29b expression in MM cells. 1574 miR-29b hsa-miR-29b-3p,hsa-miR-29b-1-5p,hsa-miR-29b-2-5p MIMAT0000100,MIMAT0004514,MIMAT0004515 miRNA VEGFA apoptosis down Homo sapiens trophoblast cells 22716646 9606 7422 MVCD1|VEGF|VPF HGNC:12680|MIM:192240|Ensembl:ENSG00000112715|HPRD:01889|Vega:OTTHUMG00000014745 6 6p12 vascular endothelial growth factor A protein-coding vascular endothelial growth factor A We found that miR-29b induced apoptosis and inhibited invasion and angiogenesis of trophoblast cells. Further studies confirmed that miR-29b regulated the expression of MCL1 (myeloid cell leukaemia sequence 1), MMP2 (encoding matrix metallproteinase 2), VEGFA (vascular endothelial growth factor A) and ITGB1 (integrin ¦Â1) genes by directly binding to their 3'-UTRs (untranslated regions). Moreover, we identified that there was an inverse correlation between miR-29b and its target genes in subjects with PE. 1575 miR-29b-3p hsa-miR-29b-3p MIMAT0000100 miRNA apoptosis Homo sapiens epidermal stem cell 25373715 9606 RT-qPCR results confirmed the upregulation of hsa-miR-197-5p and the downregulation of hsa-miR-29b-3p, which were consistent with the microarray results. miRNA target prediction indicated that the miRNA expression levels correlated with cell proliferation, differentiation, apoptosis and senescence. 1576 miR-29c hsa-miR-29c-3p,hsa-miR-29c-5p MIMAT0000681,MIMAT0004673 miRNA BCL2 apoptosis down Homo sapiens H9c2 cells 20164119 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 In contrast, overexpressing miR-29 promoted apoptosis and completely blocked the protective effect of PIO. Antagomirs against miR-29a or -29c significantly reduced myocardial infarct size and apoptosis in hearts subjected to IR injury. Western blot analyses demonstrated that Mcl-2, an anti-apoptotic Bcl-2 family member, was increased by miR-29 inhibition. 1577 miR-29c hsa-miR-29c-3p,hsa-miR-29c-5p MIMAT0000681,MIMAT0004673 miRNA BCL2 apoptosis down Homo sapiens NPC tissues and cell lines 23142283 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Our further in vitro and in vivo studies illustrated ectopic restoration of miR-29c substantially enhanced the sensitivity of NPC cells to IR and cisplatin treatment by promoting apoptosis. Furthermore, we detected miR-29c repressed expression of anti-apoptotic factors, Mcl-1 and Bcl-2 in NPC tissues and cell lines. 1578 miR-29c hsa-miR-29c-3p,hsa-miR-29c-5p MIMAT0000681,MIMAT0004673 miRNA BCL2 apoptosis down Homo sapiens plasmacytoid dendritic cell 23894561 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Bioinformatics analysis and functional studies indicated that miR-29b and miR-29c were 2 key miRNAs involved in TLR-inhibited GC-induced pDC apoptosis. Furthermore, both of these miRNAs promoted pDC apoptosis by directly targeting Mcl-1 and Bcl-2 in human primary pDCs. Our findings provide new targets that could improve the efficacy of GCs for the treatment of SLE. 1579 miR-29c hsa-miR-29c-3p,hsa-miR-29c-5p MIMAT0004673,MIMAT0000681 miRNA BCL2 apoptosis down Homo sapiens BIU-87 cell 24870742 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Exosome-derived microRNA-29c induces apoptosis of BIU-87 cells by down regulating BCL-2 and MCL-1. 1580 miR-29c hsa-miR-29c-3p,hsa-miR-29c-5p MIMAT0000681,MIMAT0004673 miRNA BCL2L2 apoptosis up Homo sapiens adenocarcinomic human alveolar basal epithelial cells 22850539 9606 599 BCL-W|BCL2-L-2|BCLW|PPP1R51 HGNC:995|MIM:601931|Ensembl:ENSG00000129473|HPRD:03569|Vega:OTTHUMG00000028738 14 14q11.2-q12 BCL2-like 2 protein-coding BCL2-like 2 Transfection of miR-29c inhibitor abolished both suppression of BCL2L2 protein expression and A549 cells apoptosis induced by influenza A virus. 1581 miR-29c hsa-miR-29c-3p,hsa-miR-29c-5p MIMAT0000681,MIMAT0004673 miRNA MCL1 apoptosis down Homo sapiens H9c2 cells 20164119 9606 4170 BCL2L3|EAT|MCL1-ES|MCL1L|MCL1S|Mcl-1|TM|bcl2-L-3|mcl1/EAT HGNC:6943|MIM:159552|Ensembl:ENSG00000143384|HPRD:08870|Vega:OTTHUMG00000034867 1 1q21 myeloid cell leukemia 1 protein-coding myeloid cell leukemia 1 In contrast, overexpressing miR-29 promoted apoptosis and completely blocked the protective effect of PIO. Antagomirs against miR-29a or -29c significantly reduced myocardial infarct size and apoptosis in hearts subjected to IR injury. Western blot analyses demonstrated that Mcl-1, an anti-apoptotic Bcl-2 family member, was increased by miR-29 inhibition. 1582 miR-29c hsa-miR-29c-3p,hsa-miR-29c-5p MIMAT0000681,MIMAT0004673 miRNA MCL1 apoptosis down Homo sapiens NPC tissues and cell lines 23142283 9606 4170 BCL2L3|EAT|MCL1-ES|MCL1L|MCL1S|Mcl-1|TM|bcl2-L-3|mcl1/EAT HGNC:6943|MIM:159552|Ensembl:ENSG00000143384|HPRD:08870|Vega:OTTHUMG00000034867 1 1q21 myeloid cell leukemia 1 protein-coding myeloid cell leukemia 1 Our further in vitro and in vivo studies illustrated ectopic restoration of miR-29c substantially enhanced the sensitivity of NPC cells to IR and cisplatin treatment by promoting apoptosis. Furthermore, we detected miR-29c repressed expression of anti-apoptotic factors, Mcl-1 and Bcl-2 in NPC tissues and cell lines. 1583 miR-29c hsa-miR-29c-3p,hsa-miR-29c-5p MIMAT0000681,MIMAT0004673 miRNA MCL1 apoptosis down Homo sapiens plasmacytoid dendritic cell 23894561 9606 4170 BCL2L3|EAT|MCL1-ES|MCL1L|MCL1S|Mcl-1|TM|bcl2-L-3|mcl1/EAT HGNC:6943|MIM:159552|Ensembl:ENSG00000143384|HPRD:08870|Vega:OTTHUMG00000034867 1 1q21 myeloid cell leukemia 1 protein-coding myeloid cell leukemia 1 Bioinformatics analysis and functional studies indicated that miR-29b and miR-29c were 2 key miRNAs involved in TLR-inhibited GC-induced pDC apoptosis. Furthermore, both of these miRNAs promoted pDC apoptosis by directly targeting Mcl-1 and Bcl-2 in human primary pDCs. Our findings provide new targets that could improve the efficacy of GCs for the treatment of SLE. 1584 miR-29c hsa-miR-29c-3p,hsa-miR-29c-5p MIMAT0004673,MIMAT0000681 miRNA MCL1 apoptosis down Homo sapiens BIU-87 cell 24870742 9606 4170 BCL2L3|EAT|MCL1-ES|MCL1L|MCL1S|Mcl-1|TM|bcl2-L-3|mcl1/EAT HGNC:6943|MIM:159552|Ensembl:ENSG00000143384|HPRD:08870|Vega:OTTHUMG00000034867 1 1q21 myeloid cell leukemia 1 protein-coding myeloid cell leukemia 1 Exosome-derived microRNA-29c induces apoptosis of BIU-87 cells by down regulating BCL-2 and MCL-1. 1585 miR-30 hsa-miR-30a-5p,hsa-miR-30a-3p,hsa-miR-30c-5p,hsa-miR-30d-5p,hsa-miR-30 MIMAT0000087,MIMAT0000088,MIMAT0000244,MIMAT000024 miRNA ITGB3 apoptosis down Homo sapiens tumor-initiating cell (T-ICs) 20498642 9606 3690 BDPLT16|BDPLT2|CD61|GP3A|GPIIIa|GT HGNC:6156|MIM:173470|Ensembl:ENSG00000259207|HPRD:01428|Vega:OTTHUMG00000171956 17 17q21.32 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) protein-coding integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) Similar to let-7, mir-30 is reduced in BT-ICs, and the protein level of Ubc9 (ubiquitin-conjugating enzyme 9) and ITGB3 (integrin beta3), the target genes of mir-30, is markedly upregulated. Enforced constitutive expression of mir-30 in BT-ICs inhibits their self-renewal capacity by reducing Ubc9, and induces apoptosis through silencing ITGB3. 1586 miR-30 hsa-miR-30a-5p,hsa-miR-30a-3p,hsa-miR-30c-5p,hsa-miR-30c-2-3p,hsa-miR-30d-5p,hsa-miR-30d-3p,hsa-miR-30b-5p,hsa-miR-30b-3p,hsa-miR-30c-1-3p,hsa-miR-30e-5p,hsa-miR-30e-3p MIMAT0000087,MIMAT0000088,MIMAT0000244,MIMAT0004550,MIMAT0000245,MIMAT0004551,MIMAT0000420,MIMAT0004589,MIMAT0004674,MIMAT0000692,MIMAT0000693, miRNA TP53 apoptosis down Homo sapiens 20062521 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 In exploring the underlying molecular mechanism, we identified that miR-30 family members can suppress p53 expression. In response to the apoptotic stimulation, the expression levels of miR-30 family members were reduced, whereas p53 was upregulated. p53 transcriptionally activated the mitochondrial fission protein, dynamin-related protein-1 (Drp1). The latter conveyed the apoptotic signal of p53 by initiating the mitochondrial fission program. 1587 miR-30 hsa-miR-30a-5p,hsa-miR-30a-3p,hsa-miR-30c-5p,hsa-miR-30d-5p,hsa-miR-30 MIMAT0000087,MIMAT0000088,MIMAT0000244,MIMAT000024 miRNA TP53 apoptosis down Homo sapiens 25137026 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 Tp53 is a validated target of miR-30 whose levels fall under ischemic conditions.The concomitant decrease in p53 protein content reduces Bax expression and limits mitochondrial membrane depolarization resulting in preserved mitochondrial function and decreased apoptosis and necrosis extent in the area at risk (AAR). 1588 miR-300 hsa-miR-300 MIMAT0004903 miRNA apoptosis Homo sapiens gastric cancer cell 24919435 9606 We predicted the targets of the two miRNAs with TargetScan and classified all the candidate targets with Gene Ontology, which indicated that both miR-300 and miR-642 potentially regulate cellular radiation response by modulating apoptosis, cell cycle regulation and DNA damage and repair pathway-related genes. 1589 miR-301a hsa-miR-301a-5p,hsa-miR-301a-3p MIMAT0022696,MIMAT0000688 miRNA MEOX2 apoptosis down Homo sapiens HCC cell 22373864 9606 4223 GAX|MOX2 HGNC:7014|MIM:600535|Ensembl:ENSG00000106511|HPRD:02760|Vega:OTTHUMG00000152390 7 7p22.1-p21.3 mesenchyme homeobox 2 protein-coding mesenchyme homeobox 2 MiR-301a was significantly upregulated and Gax was downregulated in HCC samples compared with in the matching nontumoral tissues. Inhibiting miR-301a expression caused the upregulation of Gax and repressed NF-¦ÊB expression. We have shown that miR-301a plays an important role in increasing proliferation, migration and invasion and in inhibiting apoptosis of HCC cells. 1590 miR-301a hsa-miR-301a-5p,hsa-miR-301a-3p MIMAT0022696,MIMAT0000688 miRNA NFKB1 apoptosis up Homo sapiens HCC cell 22373864 9606 4790 EBP-1|KBF1|NF-kB1|NF-kappa-B|NF-kappaB|NFKB-p105|NFKB-p50|NFkappaB|p105|p50 HGNC:7794|MIM:164011|Ensembl:ENSG00000109320|HPRD:01238|Vega:OTTHUMG00000161080 4 4q24 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 protein-coding nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 MiR-301a was significantly upregulated and Gax was downregulated in HCC samples compared with in the matching nontumoral tissues. Inhibiting miR-301a expression caused the upregulation of Gax and repressed NF-¦ÊB expression. We have shown that miR-301a plays an important role in increasing proliferation, migration and invasion and in inhibiting apoptosis of HCC cells. 1591 miR-301a hsa-miR-301a-5p,hsa-miR-301a-3p MIMAT0022696,MIMAT0000688 miRNA PRKAA1 apoptosis down Homo sapiens osteosarcoma cell 25727016 9606 5562 AMPK|AMPKa1 HGNC:9376|MIM:602739|Ensembl:ENSG00000132356|HPRD:04115|Vega:OTTHUMG00000162269 5 5p12 protein kinase, AMP-activated, alpha 1 catalytic subunit protein-coding protein kinase, AMP-activated, alpha 1 catalytic subunit MicroRNA-301a modulates doxorubicin resistance in osteosarcoma cells by targeting AMP-activated protein kinase alpha 1. Luciferase reporter assay identified AMPK¦Á1 as direct target gene of miR-301a. Notably, miR-301a reduced doxorubicin-induced cell apoptosis whereas anti-miR-301a enhanced apoptosis in OS cells, suggesting that up-regulation of miR-301a contributed to chemoresistance of OS cells. 1592 miR-302 hsa-miR-302a-5p,hsa-miR-302a-3p,hsa-miR-302b-5p,hsa-miR-302b-3p,hsa-miR-302c-5p,hsa-miR-302c-3p,hsa-miR-302d-3p,hsa-miR-302d-5p,hsa-miR-302e,hsa-miR-302f MIMAT0000683,MIMAT0000684,MIMAT0000714,MIMAT0000715,MIMAT0000716,MIMAT0000717,MIMAT0000718,MIMAT0004685,MIMAT0005931,MIMAT0005932 miRNA BCL2L11 apoptosis Homo sapiens stem cell 25184675 9606 10018 BAM|BIM|BOD HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 2 2q13 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) Moreover, we found that three miRNA families, miR-20, miR-92, and miR-302, control the mitochondrial apoptotic machinery by fine-tuning the levels of expression of the proapoptotic protein BIM. 1593 miR-302 hsa-miR-302a-5p,hsa-miR-302a-3p,hsa-miR-302b-5p,hsa-miR-302b-3p,hsa-miR-302c-5p,hsa-miR-302c-3p,hsa-miR-302d-3p,hsa-miR-302d-5p,hsa-miR-302e,hsa-miR-302f MIMAT0000683,MIMAT0000684,MIMAT0000714,MIMAT0000715,MIMAT0000716,MIMAT0000717,MIMAT0000718,MIMAT0004685,MIMAT0005931,MIMAT0005932 miRNA apoptosis down Homo sapiens embryonic stem cell 25501598 9606 Suppression of epithelial-mesenchymal transition and apoptotic pathways by miR-294/302 family synergistically blocks let-7-induced silencing of self-renewal in embryonic stem cells. 1594 miR-302a hsa-miR-302a-5p,hsa-miR-302a-3p MIMAT0000683,MIMAT0000684 miRNA BMI1 apoptosis down Homo sapiens AGS/HepG2 cell 24861464 9606 648 FLVI2/BMI1|PCGF4|RNF51 HGNC:1066|MIM:164831|Ensembl:ENSG00000168283|HPRD:01277|Vega:OTTHUMG00000017807 10 10p11.23 BMI1 proto-oncogene, polycomb ring finger protein-coding BMI1 proto-oncogene, polycomb ring finger MiR-302a and miR-4448 were markedly upregulated by treatment with SAHA and DZNep, respectively. DYRK1A, CDK2, BMI-1 and Girdin, which are targets of miR-1246, miR-302a and miR-4448, were suppressed by treatment with SAHA and DZNep, leading to apoptosis, cell cycle arrest and reduced migration of AGS and HepG2 cells. 1595 miR-302a hsa-miR-302a-5p,hsa-miR-302a-3p MIMAT0000683,MIMAT0000684 miRNA CCDC88A apoptosis down Homo sapiens AGS/HepG2 cell 24861464 9606 55704 APE|GIRDIN|GIV|GRDN|HkRP1|KIAA1212 HGNC:25523|MIM:609736|Ensembl:ENSG00000115355|HPRD:10051|HPRD:11131|Vega:OTTHUMG00000151915 2 2p16.1 coiled-coil domain containing 88A protein-coding coiled-coil domain containing 88A MiR-302a and miR-4448 were markedly upregulated by treatment with SAHA and DZNep, respectively. DYRK1A, CDK2, BMI-1 and Girdin, which are targets of miR-1246, miR-302a and miR-4448, were suppressed by treatment with SAHA and DZNep, leading to apoptosis, cell cycle arrest and reduced migration of AGS and HepG2 cells. 1596 miR-302a hsa-miR-302a-5p,hsa-miR-302a-3p MIMAT0000683,MIMAT0000684 miRNA CDK2 apoptosis down Homo sapiens AGS/HepG2 cell 24861464 9606 1017 CDKN2|p33(CDK2) HGNC:1771|MIM:116953|Ensembl:ENSG00000123374|HPRD:00310|Vega:OTTHUMG00000170575 12 12q13 cyclin-dependent kinase 2 protein-coding cyclin-dependent kinase 2 MiR-302a and miR-4448 were markedly upregulated by treatment with SAHA and DZNep, respectively. DYRK1A, CDK2, BMI-1 and Girdin, which are targets of miR-1246, miR-302a and miR-4448, were suppressed by treatment with SAHA and DZNep, leading to apoptosis, cell cycle arrest and reduced migration of AGS and HepG2 cells. 1597 miR-302a hsa-miR-302a-5p,hsa-miR-302a-3p MIMAT0000683,MIMAT0000684 miRNA DYRK1A apoptosis down Homo sapiens AGS/HepG2 cell 24861464 9606 1859 DYRK|DYRK1|HP86|MNB|MNBH|MRD7 HGNC:3091|MIM:600855|Ensembl:ENSG00000157540|HPRD:09018|Vega:OTTHUMG00000086657 21 21q22.13 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A protein-coding dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A MiR-302a and miR-4448 were markedly upregulated by treatment with SAHA and DZNep, respectively. DYRK1A, CDK2, BMI-1 and Girdin, which are targets of miR-1246, miR-302a and miR-4448, were suppressed by treatment with SAHA and DZNep, leading to apoptosis, cell cycle arrest and reduced migration of AGS and HepG2 cells. 1598 miR-302a hsa-miR-302a-5p,hsa-miR-302a-3p MIMAT0000683,MIMAT0000684 miRNA apoptosis Homo sapiens NT2 cell 23625774 9606 7157 TP53|BCC7|LFS1|TRP53 HGNC:11998|Ensembl:ENSG00000141510|HPRD:01859|MIM:191170|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein coding tumor protein p53 MiR-302a induced apoptosis was further enhanced by silencing of p53 in NT2 cells. p53 levels were inversely associated with the expression of Oct4, Sox2, and Nanog in response to cisplatin. Thus, targeting miR-302a may offer new therapeutic interventions in TGCT. 1599 miR-302b hsa-miR-302b-5p,hsa-miR-302b-3p MIMAT0000714,MIMAT0000715 miRNA AKT1 apoptosis up Homo sapiens osteosarcoma cell 23845851 9606 207 AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA HGNC:391|MIM:164730|Ensembl:ENSG00000142208|HPRD:01261|Vega:OTTHUMG00000170795 14 14q32.32 v-akt murine thymoma viral oncogene homolog 1 protein-coding v-akt murine thymoma viral oncogene homolog 1 Notably, miR-302b, which is stably low-expressed in osteosarcoma, could be induced by the epirubicin. Furthermore, we find that miR-302b can inhibit the osteosarcoma cell proliferation, promote cell apoptosis and cell cycle arrest MiR-302b can activate caspase-3 and regulate the Akt/pAkt, Bcl-2, Bim expression to increase the cell apoptosis. Meanwhile, miR-302b also attenuates cyclin D1 and CDKs expression to induce cell cycle arrest. 1600 miR-302b hsa-miR-302b-5p,hsa-miR-302b-3p MIMAT0000714,MIMAT0000715 miRNA BCL2 apoptosis up Homo sapiens osteosarcoma cell 23845851 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Notably, miR-302b, which is stably low-expressed in osteosarcoma, could be induced by the epirubicin. Furthermore, we find that miR-302b can inhibit the osteosarcoma cell proliferation, promote cell apoptosis and cell cycle arrest MiR-302b can activate caspase-3 and regulate the Akt/pAkt, Bcl-2, Bim expression to increase the cell apoptosis. Meanwhile, miR-302b also attenuates cyclin D1 and CDKs expression to induce cell cycle arrest. 1601 miR-302b hsa-miR-302b-5p,hsa-miR-302b-3p MIMAT0000714,MIMAT0000715 miRNA BCL2L11 apoptosis up Homo sapiens osteosarcoma cell 23845851 9606 10018 BAM|BIM|BOD HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 2 2q13 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) Notably, miR-302b, which is stably low-expressed in osteosarcoma, could be induced by the epirubicin. Furthermore, we find that miR-302b can inhibit the osteosarcoma cell proliferation, promote cell apoptosis and cell cycle arrest MiR-302b can activate caspase-3 and regulate the Akt/pAkt, Bcl-2, Bim expression to increase the cell apoptosis. Meanwhile, miR-302b also attenuates cyclin D1 and CDKs expression to induce cell cycle arrest. 1602 miR-302b hsa-miR-302b-5p,hsa-miR-302b-3p MIMAT0000714,MIMAT0000715 miRNA CASP3 apoptosis up Homo sapiens osteosarcoma cell 23845851 9606 836 CPP32|CPP32B|SCA-1 HGNC:1504|MIM:600636|Ensembl:ENSG00000164305|HPRD:02799|Vega:OTTHUMG00000133681 4 4q34 caspase 3, apoptosis-related cysteine peptidase protein-coding caspase 3, apoptosis-related cysteine peptidase Notably, miR-302b, which is stably low-expressed in osteosarcoma, could be induced by the epirubicin. Furthermore, we find that miR-302b can inhibit the osteosarcoma cell proliferation, promote cell apoptosis and cell cycle arrest MiR-302b can activate caspase-3 and regulate the Akt/pAkt, Bcl-2, Bim expression to increase the cell apoptosis. Meanwhile, miR-302b also attenuates cyclin D1 and CDKs expression to induce cell cycle arrest. 1603 miR-302b hsa-miR-302b-5p,hsa-miR-302b-3p MIMAT0000714,MIMAT0000715 miRNA CCND1 apoptosis down Homo sapiens osteosarcoma cell 23845851 9606 595 BCL1|D11S287E|PRAD1|U21B31 HGNC:1582|MIM:168461|Ensembl:ENSG00000110092|HPRD:01346|Vega:OTTHUMG00000167877 11 11q13 cyclin D1 protein-coding cyclin D1 Notably, miR-302b, which is stably low-expressed in osteosarcoma, could be induced by the epirubicin. Furthermore, we find that miR-302b can inhibit the osteosarcoma cell proliferation, promote cell apoptosis and cell cycle arrest MiR-302b can activate caspase-3 and regulate the Akt/pAkt, Bcl-2, Bim expression to increase the cell apoptosis. Meanwhile, miR-302b also attenuates cyclin D1 and CDKs expression to induce cell cycle arrest. 1604 miR-302b hsa-miR-302b-3p,hsa-miR-302b-5p MIMAT0000714,MIMAT0000715 miRNA CCND2 apoptosis down Homo sapiens SH-SY5Y cell 21878650 9606 894 KIAK0002 HGNC:1583|MIM:123833|Ensembl:ENSG00000118971|HPRD:00451|Vega:OTTHUMG00000168123 12 12p13 cyclin D2 protein-coding cyclin D2 Cotransfection studies with 3'-UTR of these genes and miRNA mimics have demonstrated that BCL2 is a direct target of miR-497 and that CCND2 is regulated negatively by either miR-302b or miR-497. Overexpression of either miR-497 or miR-302b reduced expression of their identified target genes and increased caspase 3-mediated apoptosis of SH-SY5Y cells. 1605 miR-302b hsa-miR-302b-5p,hsa-miR-302b-3p MIMAT0000714,MIMAT0000715 miRNA CDK7 apoptosis down Homo sapiens osteosarcoma cell 23845851 9606 1022 CAK1|CDKN7|HCAK|MO15|STK1|p39MO15 HGNC:1778|MIM:601955|Ensembl:ENSG00000134058|HPRD:15993|Vega:OTTHUMG00000099358 5 5q12.1 cyclin-dependent kinase 7 protein-coding cyclin-dependent kinase 7 Notably, miR-302b, which is stably low-expressed in osteosarcoma, could be induced by the epirubicin. Furthermore, we find that miR-302b can inhibit the osteosarcoma cell proliferation, promote cell apoptosis and cell cycle arrest MiR-302b can activate caspase-3 and regulate the Akt/pAkt, Bcl-2, Bim expression to increase the cell apoptosis. Meanwhile, miR-302b also attenuates cyclin D1 and CDKs expression to induce cell cycle arrest. 1606 miR-302b hsa-miR-302b-3p,hsa-miR-302b-5p MIMAT0000714,MIMAT0000715 miRNA E2F3 apoptosis down Homo sapiens glioma cell 25040912 9606 1871 E2F-3 HGNC:3115|MIM:600427|Ensembl:ENSG00000112242|HPRD:02693|Vega:OTTHUMG00000016389 6 6p22 E2F transcription factor 3 protein-coding E2F transcription factor 3 E2F3, an important transcriptional regulator of glioma proliferation, was validated to be a direct target gene of miR-302b. The miR-302b-reduced E2F3 levels were also identified to be associated with ATRA-mediated glioma cell death. These results emphasize that an ATRA-mediated miR-302b network may provide novel therapeutic strategies for glioblastoma therapy. 1607 miR-302b hsa-miR-302b-3p,hsa-miR-302b-5p MIMAT0000714,MIMAT0000715 miRNA ERBB4 apoptosis down Homo sapiens esophageal squamous cell 24438167 9606 2066 ALS19|HER4|p180erbB4 HGNC:3432|MIM:600543|Ensembl:ENSG00000178568|HPRD:02767|Vega:OTTHUMG00000133012 2 2q33.3-q34 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 protein-coding v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 MiR-302b was significantly down-regulated and correlated with tumor differentiation and lymph node metastasis in ESCC. Univariate and multivariate analyses indicated that low miR-302b expression might be a poor prognostic factor. Further studies demonstrated that miR-302b post-transcriptionally down-regulated the expression of ErbB4 in vitro. Moreover, miR-302b inhibited proliferation by inducing apoptosis and repressed invasion in the ESCC cell lines. 1608 miR-302b hsa-miR-302b-3p,hsa-miR-302b-5p MIMAT0000714,MIMAT0000715 miRNA RUNX1 apoptosis down Homo sapiens ovarian cancer cell 25562167 9606 861 AML1|AML1-EVI-1|AMLCR1|CBFA2|EVI-1|PEBP2aB HGNC:10471|MIM:151385|Ensembl:ENSG00000159216|HPRD:01043|Vega:OTTHUMG00000086299 21 21q22.3 runt-related transcription factor 1 protein-coding runt-related transcription factor 1 Ectopic expression of miR-302b in EOC cells inhibited cell proliferation and colony formation, induced G0/G1 arrest, and promoted apoptosis. RUNX1 was identified as a direct target of miR-302b, and knockdown of RUNX1 inhibited cell growth in a manner similar to miR-302b overexpression, whereas introduction of a 3'UTR mutant of RUNX1 reversed the suppressive effect of miR-302b. 1609 miR-30a hsa-miR-30a-5p,hsa-miR-30a-3p MIMAT0000087,MIMAT0000088 miRNA BECN1 apoptosis down Homo sapiens chronic myeloid leukemia cells 22395361 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related miR-30a is a potent inhibitor of autophagy by downregulating Beclin 1 and ATG5 expression. 1610 miR-30a-5p hsa-miR-30a-5p MIMAT0000087 miRNA 7-Sep apoptosis down Homo sapiens glioblastoma cells 23383034 9606 989 CDC10|CDC3|NBLA02942|SEPT7A HGNC:1717|MIM:603151|HPRD:04398 7 7p14.2 septin 7 protein-coding septin 7 SEPT7 is a member of the septin family, which is a highly conserved subfamily of GTPases implicated in exocytosis, apoptosis, synaptogenesis, neurodegeneration and tumorigenesis. Our previous study has also demonstrated that SEPT7 expression is decreased in astrocytic gliomas with different grades and plays a tumor suppressor role. Additionaly, miR-30a-5p directly targeting SEPT7 was identified by the reporter gene assay. 1611 miR-30b hsa-miR-30b-5p,hsa-miR-30b-3p MIMAT0000420,MIMAT0004589 miRNA BCL2 apoptosis down Homo sapiens cardiomyocytes 24178239 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Our results demonstrated that NF-¦ÊB positively regulated miR-30b expression in Ang II-induced cardiomyocytes apoptosis, and Bcl-2 was a direct target for miR-30b. 1612 miR-30b hsa-miR-30b-5p,hsa-miR-30b-3p MIMAT0000420,MIMAT0004589 miRNA CASP3 apoptosis down Homo sapiens tumor necrosis factor-related apoptosis-inducing ligand-resistant glioma cells 22964638 9606 836 CPP32|CPP32B|SCA-1 HGNC:1504|MIM:600636|Ensembl:ENSG00000164305|HPRD:02799|Vega:OTTHUMG00000133681 4 4q34 caspase 3, apoptosis-related cysteine peptidase protein-coding caspase 3, apoptosis-related cysteine peptidase We show that in TRAIL-resistant glioma cells, levels of different miRs are increased, and in particular, miR-30b/c and -21. We demonstrate that these miRs impair TRAIL-dependent apoptosis by inhibiting the expression of key functional proteins.Furthermore, we demonstrate that miR-30b/c and miR-21 target respectively the 3' untranslated region of caspase-3 and TAp63 mRNAs, and that those proteins mediate some of the effects of miR-30 and -21 on TRAIL resistance, even in human glioblastoma primary cells and in lung cancer cells. 1613 miR-30b hsa-miR-30b-5p,hsa-miR-30b-3p MIMAT0000420,MIMAT0004589 miRNA CASP3 apoptosis down Homo sapiens 23968872 9606 836 CPP32|CPP32B|SCA-1 HGNC:1504|MIM:600636|Ensembl:ENSG00000164305|HPRD:02799|Vega:OTTHUMG00000133681 4 4q34 caspase 3, apoptosis-related cysteine peptidase protein-coding caspase 3, apoptosis-related cysteine peptidase Transfection of a mimic of miRNA-30b led to decreases in alkaline phosphatase activity and expressions of Runx2, Smad1, and caspase-3. Furthermore, dual luciferase reporter assays confirmed that Runx2, Smad1, and caspase-3 are direct targets of miRNA-30b. 1614 miR-30b hsa-miR-30b-5p,hsa-miR-30b-3p MIMAT0000420,MIMAT0004589 miRNA RUNX2 apoptosis down Homo sapiens 23968872 9606 860 AML3|CBF-alpha-1|CBFA1|CCD|CCD1|CLCD|OSF-2|OSF2|PEA2aA|PEBP2aA HGNC:10472|MIM:600211|Ensembl:ENSG00000124813|HPRD:02566|Vega:OTTHUMG00000014774 6 6p21 runt-related transcription factor 2 protein-coding runt-related transcription factor 2 Transfection of a mimic of miRNA-30b led to decreases in alkaline phosphatase activity and expressions of Runx2, Smad1, and caspase-3. Furthermore, dual luciferase reporter assays confirmed that Runx2, Smad1, and caspase-3 are direct targets of miRNA-30b. 1615 miR-30b hsa-miR-30b-5p,hsa-miR-30b-3p MIMAT0000420,MIMAT0004589 miRNA SMAD1 apoptosis down Homo sapiens 23968872 9606 4086 BSP-1|BSP1|JV4-1|JV41|MADH1|MADR1 HGNC:6767|MIM:601595|Ensembl:ENSG00000170365|HPRD:03356|Vega:OTTHUMG00000161592 4 4q31 SMAD family member 1 protein-coding SMAD family member 1 Transfection of a mimic of miRNA-30b led to decreases in alkaline phosphatase activity and expressions of Runx2, Smad1, and caspase-3. Furthermore, dual luciferase reporter assays confirmed that Runx2, Smad1, and caspase-3 are direct targets of miRNA-30b. 1616 miR-30c hsa-miR-30c-5p,hsa-miR-30c-2-3p,hsa-miR-30c-1-3p MIMAT0000244,MIMAT0004550,MIMAT0004674 miRNA CASP3 apoptosis down Homo sapiens tumor necrosis factor-related apoptosis-inducing ligand-resistant glioma cells 22964638 9606 836 CPP32|CPP32B|SCA-1 HGNC:1504|MIM:600636|Ensembl:ENSG00000164305|HPRD:02799|Vega:OTTHUMG00000133681 4 4q34 caspase 3, apoptosis-related cysteine peptidase protein-coding caspase 3, apoptosis-related cysteine peptidase We show that in TRAIL-resistant glioma cells, levels of different miRs are increased, and in particular, miR-30b/c and -21. We demonstrate that these miRs impair TRAIL-dependent apoptosis by inhibiting the expression of key functional proteins.Furthermore, we demonstrate that miR-30b/c and miR-21 target respectively the 3' untranslated region of caspase-3 and TAp63 mRNAs, and that those proteins mediate some of the effects of miR-30 and -21 on TRAIL resistance, even in human glioblastoma primary cells and in lung cancer cells. 1617 miR-30d hsa-miR-30d-5p,hsa-miR-30d-3p MIMAT0000245,MIMAT0004551 miRNA MTDH apoptosis down Homo sapiens renal cell carcinoma cells 23416459 9606 92140 3D3|AEG-1|AEG1|LYRIC|LYRIC/3D3 HGNC:29608|MIM:610323|Ensembl:ENSG00000147649|HPRD:17459|Vega:OTTHUMG00000164692 8 8q22.1 metadherin protein-coding metadherin Functional analysis revealed that miR-30d overexpression suppresses cell proliferation and induces apoptosis in RCC cells, suggesting that miR-30d acts as a tumor suppressor. In searching for downstream targets of miR-30d, we found that miR-30d post-transcriptionally suppresses expression of the oncoprotein metadherin (MTDH) by destabilizing its mRNA. 1618 miR-31 hsa-miR-31-5p,hsa-miR-31-3p MIMAT0000089,MIMAT0004504 miRNA ABCB9 apoptosis down Homo sapiens lung 24099915 9606 23457 EST122234|TAPL HGNC:50|MIM:605453|Ensembl:ENSG00000150967|HPRD:09262|Vega:OTTHUMG00000168769 12 12q24 ATP-binding cassette, sub-family B (MDR/TAP), member 9 protein-coding ATP-binding cassette, sub-family B (MDR/TAP), member 9 Mechanistically, we showed that miR-31 confers DDP-induced apoptosis and that inhibition of ABCB9 is required for DDP resistance. The data demonstrate that miR-31 exerts an anti-apoptotic effect most likely through the inhibition of ABCB9 and thus provide a novel strategy involving the use of miR-31 as a potential target in NSCLC chemotherapy 1619 miR-31 hsa-miR-31-5p,hsa-miR-31-3p MIMAT0000089,MIMAT0004504 miRNA apoptosis Homo sapiens SEB-activated cells 25706292 9606 9606 Both compounds also down-regulated miR-31, which directly targets caspase-2 and influences apoptosis in SEB-activated cells. 1620 miR-3189 hsa-miR-3189-3p,hsa-miR-3189-5p MIMAT0015071,MIMAT0019217 miRNA CDKN1A apoptosis up Homo sapiens 25698447 9606 1026 CAP20|CDKN1|CIP1|MDA-6|P21|SDI1|WAF1|p21CIP1 HGNC:1784|MIM:116899|Ensembl:ENSG00000124762|HPRD:00298|Vega:OTTHUMG00000014603 6 6p21.2 cyclin-dependent kinase inhibitor 1A (p21, Cip1) protein-coding cyclin-dependent kinase inhibitor 1A (p21, Cip1) miR-3189 targets revealed that miR-3189 directly inhibits the expression of a large number of genes involved in cell cycle control and cell survival. In addition, miR-3189 downregulated the expression of multiple p53 inhibitors resulting in elevated p53 levels and upregulation of several p53 targets including p21 (CDKN1A), GADD45A and the miR-3189 host gene GDF15, suggesting miR-3189 auto-regulation. Surprisingly, miR-3189 overexpression in p53-/- cells upregulated a subset of p53-targets including GDF15, GADD45A, and NOXA, but not CDKN1A. Consistent with these results, overexpression of miR-3189 potently induced apoptosis and inhibited tumorigenicity in vivo in a p53-independent manner. 1621 miR-3189 hsa-miR-3189-3p,hsa-miR-3189-5p MIMAT0015071,MIMAT0019217 miRNA GADD45A apoptosis up Homo sapiens 25698447 9606 1647 DDIT1|GADD45 HGNC:4095|MIM:126335|Ensembl:ENSG00000116717|HPRD:00528|Vega:OTTHUMG00000009374 1 1p31.2 growth arrest and DNA-damage-inducible, alpha protein-coding growth arrest and DNA-damage-inducible, alpha miR-3189 targets revealed that miR-3189 directly inhibits the expression of a large number of genes involved in cell cycle control and cell survival. In addition, miR-3189 downregulated the expression of multiple p53 inhibitors resulting in elevated p53 levels and upregulation of several p53 targets including p21 (CDKN1A), GADD45A and the miR-3189 host gene GDF15, suggesting miR-3189 auto-regulation. Surprisingly, miR-3189 overexpression in p53-/- cells upregulated a subset of p53-targets including GDF15, GADD45A, and NOXA, but not CDKN1A. Consistent with these results, overexpression of miR-3189 potently induced apoptosis and inhibited tumorigenicity in vivo in a p53-independent manner. 1622 miR-3189 hsa-miR-3189-3p,hsa-miR-3189-5p MIMAT0015071,MIMAT0019217 miRNA GDF15 apoptosis up Homo sapiens 25698447 9606 9518 GDF-15|MIC-1|MIC1|NAG-1|PDF|PLAB|PTGFB HGNC:30142|MIM:605312|Ensembl:ENSG00000130513|HPRD:05608|Vega:OTTHUMG00000183360 19 19p13.11 growth differentiation factor 15 protein-coding growth differentiation factor 15 miR-3189 targets revealed that miR-3189 directly inhibits the expression of a large number of genes involved in cell cycle control and cell survival. In addition, miR-3189 downregulated the expression of multiple p53 inhibitors resulting in elevated p53 levels and upregulation of several p53 targets including p21 (CDKN1A), GADD45A and the miR-3189 host gene GDF15, suggesting miR-3189 auto-regulation. Surprisingly, miR-3189 overexpression in p53-/- cells upregulated a subset of p53-targets including GDF15, GADD45A, and NOXA, but not CDKN1A. Consistent with these results, overexpression of miR-3189 potently induced apoptosis and inhibited tumorigenicity in vivo in a p53-independent manner. 1623 miR-3189 hsa-miR-3189-3p,hsa-miR-3189-5p MIMAT0015071,MIMAT0019217 miRNA PMAIP1 apoptosis up Homo sapiens 25698447 9606 5366 APR|NOXA HGNC:9108|MIM:604959|Ensembl:ENSG00000141682|HPRD:12002|Vega:OTTHUMG00000132765 18 18q21.32 phorbol-12-myristate-13-acetate-induced protein 1 protein-coding phorbol-12-myristate-13-acetate-induced protein 1 miR-3189 targets revealed that miR-3189 directly inhibits the expression of a large number of genes involved in cell cycle control and cell survival. In addition, miR-3189 downregulated the expression of multiple p53 inhibitors resulting in elevated p53 levels and upregulation of several p53 targets including p21 (CDKN1A), GADD45A and the miR-3189 host gene GDF15, suggesting miR-3189 auto-regulation. Surprisingly, miR-3189 overexpression in p53-/- cells upregulated a subset of p53-targets including GDF15, GADD45A, and NOXA, but not CDKN1A. Consistent with these results, overexpression of miR-3189 potently induced apoptosis and inhibited tumorigenicity in vivo in a p53-independent manner. 1624 miR-3189 hsa-miR-3189-3p,hsa-miR-3189-5p MIMAT0015071,MIMAT0019217 miRNA TP53 apoptosis up Homo sapiens 25698447 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 miR-3189 targets revealed that miR-3189 directly inhibits the expression of a large number of genes involved in cell cycle control and cell survival. In addition, miR-3189 downregulated the expression of multiple p53 inhibitors resulting in elevated p53 levels and upregulation of several p53 targets including p21 (CDKN1A), GADD45A and the miR-3189 host gene GDF15, suggesting miR-3189 auto-regulation. Surprisingly, miR-3189 overexpression in p53-/- cells upregulated a subset of p53-targets including GDF15, GADD45A, and NOXA, but not CDKN1A. Consistent with these results, overexpression of miR-3189 potently induced apoptosis and inhibited tumorigenicity in vivo in a p53-independent manner. 1625 miR-32 hsa-miR-32-5p,hsa-miR-32-3p MIMAT0000090,MIMAT0004505 miRNA BCL2L11 apoptosis down Homo sapiens prostate cancer cells 18676839 9606 10018 BAM|BIM|BOD HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 2 2q13 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) bcl-2 interacting mediato In cell culture, E2F1 and p21/WAF1 were identified as targets of miR-106b, Bim of miR-32, and exportin-6 and protein tyrosine kinase 9 of miR-1. 1626 miR-32 hsa-miR-32-5p,hsa-miR-32-3p MIMAT0000090,MIMAT0004505 miRNA BTG2 apoptosis down Homo sapiens androgen-sensitive human prostate adenocarcinoma cells 22266859 9606 7832 PC3|TIS21 HGNC:1131|MIM:601597|Ensembl:ENSG00000159388|HPRD:03357|Vega:OTTHUMG00000035834 1 1q32 BTG family, member 2 protein-coding BTG family, member 2 miR-32 was demonstrated to reduce apoptosis, whereas miR-148a enhanced proliferation. 1627 miR-320 hsa-mir-320a,hsa-miR-320b,hsa-miR-320c MIMAT0000510,MIMAT0005792,MIMAT0005793 miRNA BCL2 apoptosis down Homo sapiens cholangiocarcinoma cells 19070389 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 apoptosis regulator Bcl-2 The exogenous expression of mir-320 or mir-204 could negatively regulate Mcl-1 or Bcl-2 expression and facilitate chemotherapeutic drug-triggered apoptosis. 1628 miR-320 hsa-mir-320a,hsa-miR-320b,hsa-miR-320c MIMAT0000510,MIMAT0005792,MIMAT0005793 miRNA MCL1 apoptosis down Homo sapiens cholangiocarcinoma cells 19070389 9606 4170 BCL2L3|EAT|MCL1-ES|MCL1L|MCL1S|Mcl-1|TM|bcl2-L-3|mcl1/EAT HGNC:6943|MIM:159552|Ensembl:ENSG00000143384|HPRD:08870|Vega:OTTHUMG00000034867 1 1q21 myeloid cell leukemia 1 protein-coding myeloid cell leukemia 1 apoptosis regulator Bcl-2 The exogenous expression of mir-320 or mir-204 could negatively regulate Mcl-1 or Bcl-2 expression and facilitate chemotherapeutic drug-triggered apoptosis. 1629 miR-320a hsa-miR-320a MIMAT0000510 miRNA BANP apoptosis down Homo sapiens K563 cell 23876508 9606 54971 BEND1|SMAR1|SMARBP1 HGNC:13450|MIM:611564|Ensembl:ENSG00000172530|HPRD:16538|Vega:OTTHUMG00000137678 16 16q24 BTG3 associated nuclear protein protein-coding BTG3 associated nuclear protein miR-320a negatively regulates the expression of SMAR1 by directly binding to its 3'UTR. In response to mild DNA damage, miR-320a expression is decreased resulting in enhanced expression of SMAR1 protein, which in turn, reduces its targets, Bax and Puma inhibiting apoptosis. 1630 miR-320a hsa-miR-320a MIMAT0000510 miRNA BAX apoptosis down Homo sapiens K562 cell 23876508 9606 581 BCL2L4 HGNC:959|MIM:600040|Ensembl:ENSG00000087088|HPRD:02498|Vega:OTTHUMG00000160476 19 19q13.3-q13.4 BCL2-associated X protein protein-coding BCL2-associated X protein miR-320a negatively regulates the expression of SMAR1 by directly binding to its 3'UTR. In response to mild DNA damage, miR-320a expression is decreased resulting in enhanced expression of SMAR1 protein, which in turn, reduces its targets, Bax and Puma inhibiting apoptosis. 1631 miR-320a hsa-miR-320a MIMAT0000510 miRNA BBC3 apoptosis down Homo sapiens K563 cell 23876508 9606 27113 JFY-1|JFY1|PUMA HGNC:17868|MIM:605854|Ensembl:ENSG00000105327|HPRD:16165|Vega:OTTHUMG00000183489 19 19q13.3-q13.4 BCL2 binding component 3 protein-coding BCL2 binding component 3 miR-320a negatively regulates the expression of SMAR1 by directly binding to its 3'UTR. In response to mild DNA damage, miR-320a expression is decreased resulting in enhanced expression of SMAR1 protein, which in turn, reduces its targets, Bax and Puma inhibiting apoptosis. 1632 miR-320a hsa-miR-320a MIMAT0000510 miRNA SP1 apoptosis Homo sapiens vessel 25728840 9606 6667 - HGNC:11205|MIM:189906|Ensembl:ENSG00000185591|HPRD:01796|Vega:OTTHUMG00000170047 12 12q13.1 Sp1 transcription factor protein-coding Sp1 transcription factor Moreover, miR-320a expression inhibits human-derived endothelium cell proliferation and induces apoptosis. We also found that SP1 transcriptionally up-regulates hsa-miR-320a expression. Our observations indicate that miR-320a is a key regulator contributing to multiple aspects of atherogenesis. 1633 miR-322 miRNA TRAF3 apoptosis down Homo sapiens neural stem cell 25516495 9606 7187 CAP-1|CAP1|CD40bp|CRAF1|IIAE5|LAP1 HGNC:12033|MIM:601896|Ensembl:ENSG00000131323|HPRD:03539|Vega:OTTHUMG00000171902 14 14q32.32 TNF receptor-associated factor 3 protein-coding TNF receptor-associated factor 3 MiR-322 interacts with the 3'-UTR of TRAF3 and represses its translation. The miR-322-TRAF3 pathway is implicated in high glucose-induced caspase activation and apoptosis. 1634 miR-323-5p hsa-miR-323a-5p MIMAT0004696 miRNA IGF1R apoptosis Homo sapiens glioma cell 25556445 9606 3480 CD221|IGFIR|IGFR|JTK13 HGNC:5465|MIM:147370|Ensembl:ENSG00000140443|HPRD:00932|Vega:OTTHUMG00000149851 15 15q26.3 insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor Our findings showed that over-expression of miR-323-5p could promote apoptosis of U251 and inhibit the proliferation and migration of the glioma cells.In addition, dual-luciferase reporter assays were performed to determine the target site of miR-323-5p to IGF-1R 3'UTR. 1635 miR-326 hsa-miR-326 MIMAT0000756 miRNA HDAC3 apoptosis Homo sapiens 25138213 9606 8841 HD3|RPD3|RPD3-2 HGNC:4854|MIM:605166|Ensembl:ENSG00000171720|HPRD:08950|Vega:OTTHUMG00000129629 5 5q31 histone deacetylase 3 protein-coding histone deacetylase 3 HDAC3 showed a positive feedback loop with miRNAs such as miR-200b, miR-217, and miR-335. miR-200b, miR-217, and miR-335 negatively regulated the expression of miR-326 and the invasion and migration potential of cancer cells while enhancing the apoptotic effect of anti-cancer drugs. TargetScan analysis predicted miR-200b and miR-217 as negative regulators of cancer-associated gene, a cancer/testis antigen, which is known to regulate the response to anti-cancer drugs. HDAC3 and miR-326 acted upstream of the cancer-associated gene. Thus, we show that the miR-326-HDAC3 feedback loop can be employed as a target for the development of anti-cancer therapeutics. 1636 miR-326 hsa-miR-326 MIMAT0000756 miRNA NOB1 apoptosis down Homo sapiens glioma cell 23869222 9606 28987 ART-4|MST158|NOB1P|PSMD8BP1 HGNC:29540|MIM:613586|Ensembl:ENSG00000141101|HPRD:11395|Vega:OTTHUMG00000137576 16 16q22.3 NIN1/RPN12 binding protein 1 homolog (S. cerevisiae) protein-coding NIN1/RPN12 binding protein 1 homolog (S. cerevisiae) In the present study, the human Nin one binding protein (NOB1) was identified as a direct target of miR-326 and a potential oncogene in human glioma. Similar to NOB1 silencing by shRNA, overexpression of miR-326 in human glioma cell lines (A172 and U373) caused cell cycle arrest at the G1 phase, delayed cell proliferation and enhanced apoptosis. 1637 miR-326 hsa-miR-326 MIMAT0000756 miRNA PKM apoptosis down Homo sapiens glioma cell 20667897 9606 5315 CTHBP|HEL-S-30|OIP3|PK3|PKM2|TCB|THBP1 HGNC:9021|MIM:179050|Ensembl:ENSG00000067225|HPRD:01529|Vega:OTTHUMG00000172709 15 15q22 pyruvate kinase, muscle protein-coding pyruvate kinase, muscle Ectopic expression of miRNA-326 in glioma and glioma stem cells induced their apoptosis and reduced their metabolic activity. Strikingly, cells with high levels of PKM2 expressed lower levels of miR-326, suggestive of endogenous regulation of PKM2 by miR-326. 1638 miR-326 hsa-miR-326 MIMAT0000756 miRNA SMO apoptosis down Homo sapiens chronic myeloid leukemia CD34(+) cells 23341351 9606 6608 FZD11|Gx|SMOH HGNC:11119|MIM:601500|Ensembl:ENSG00000128602|HPRD:03294|Vega:OTTHUMG00000158421 7 7q32.3 smoothened, frizzled class receptor protein-coding smoothened, frizzled class receptor Additionally, overexpression of miR-326 led to downregulation of Smo, resulted in decreased cell proliferation and elevated rate of apoptosis in CML CD34(+) cells 1639 miR-328 hsa-miR-328-3p,hsa-miR-328-5p MIMAT0026486,MIMAT0000752 miRNA IGF1R apoptosis down Homo sapiens 22392900 9606 3480 CD221|IGFIR|IGFR|JTK13 HGNC:5465|MIM:147370|Ensembl:ENSG00000140443|HPRD:00932|Vega:OTTHUMG00000149851 15 15q26.3 insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor Furthermore, miRNA-328 suppressed the insulin growth factor 1 receptor, ultimately leading to apoptosis of pulmonary arterial smooth muscle cells. The posttranscriptional repression of L-type calcium channel-¦Á1C and insulin growth factor 1 receptor was further confirmed by luciferase reporter assay. These results showed that miRNA-328, an important protecting factor, plays a significant role in PA constriction and remodeling by regulating multiple gene targets in hypoxic pulmonary hypertension. 1640 miR-328 hsa-miR-328-3p,hsa-miR-328-5p MIMAT0026486,MIMAT0000752 miRNA apoptosis Homo sapiens biliary cell 19345069 9606 Quantitative PCR was employed to validate down-regulation of microRNA-122a (miR-122a) and miR-26a and the increased expression of miR-328 and miR-299-5p. The predicted targets of these miRNAs are known to affect cell proliferation, apoptosis, inflammation, oxidative stress, and metabolism. Our data are the first to demonstrate that PBC is characterized by altered expression of hepatic miRNA; however additional studies are required to demonstrate a causal link between those miRNA and the development of PBC. 1641 miR-330 hsa-miR-330-3p,hsa-miR-330-5p MIMAT0000751,MIMAT0004693 miRNA CDC42 apoptosis down Homo sapiens colorectal cancer cell 23337504 9606 998 CDC42Hs|G25K HGNC:1736|MIM:116952|Ensembl:ENSG00000070831|HPRD:00309|Vega:OTTHUMG00000002753 1 1p36.1 cell division cycle 42 protein-coding cell division cycle 42 Ectopic expression of miR-330 down-regulated Cdc42 expression at both protein and mRNA level, mimicked the effect of Cdc42 knockdown in inhibiting proliferation, inducing G1 cell cycle arrest and apoptosis of the colorectal cancer cells, whereas restoration of Cdc42 could partially attenuate the effects of miR-330. In addition, elevated expression of miR-330 could suppress the immediate downstream effectors of Cdc42 and inhibit the growth of colorectal cancer cells in vivo. To sum up, our results establish a role of miR-330 in negatively regulating Cdc42 expression and colorectal cancer cell proliferation. They suggest that manipulating the expression level of Cdc42 by miR-330 has the potential to influence colorectal cancer progression. 1642 miR-330 hsa-miR-330-5p,hsa-miR-330-3p MIMAT0004693,MIMAT0000751 miRNA SH3GL2 apoptosis down Homo sapiens glioblastoma cell 24736727 9606 6456 CNSA2|EEN-B1|SH3D2A|SH3P4 HGNC:10831|MIM:604465|Ensembl:ENSG00000107295|HPRD:05125|Vega:OTTHUMG00000019601 9 9p22 SH3-domain GRB2-like 2 protein-coding SH3-domain GRB2-like 2 The expression of miR-330 enhanced cellular proliferation, promoted cell migration and invasion, and dampened cell apoptosis. When the GSCs were co-transfected with the plasmid containing short hairpin RNA directed against human SH3GL2 gene and miR-330 mimic, we found that miR-330 promoted the malignant behavior of GSCs by down-regulating the expression of SH3GL2. 1643 miR-335 hsa-miR-335-5p,hsa-miR-335-3p MIMAT0000765,MIMAT0004703 miRNA BCL2L2 apoptosis down Homo sapiens lung cancer cells 23740614 9606 599 BCL-W|BCL2-L-2|BCLW|PPP1R51 HGNC:995|MIM:601931|Ensembl:ENSG00000129473|HPRD:03569|Vega:OTTHUMG00000028738 14 14q11.2-q12 BCL2-like 2 protein-coding BCL2-like 2 These results indicated that upregulation of miR-335 can simultaneously suppress the invasiveness and promote apoptosis of lung cancer cell A549 and H1299 by targeting Bcl-w and SP1. 1644 miR-335 hsa-miR-335-5p,hsa-miR-335-3p MIMAT0000765,MIMAT0004703 miRNA BRCA1 apoptosis up Homo sapiens breast cancer cell 21618216 9606 672 BRCAI|BRCC1|BROVCA1|IRIS|PNCA4|PPP1R53|PSCP|RNF53 HGNC:1100|MIM:113705|Ensembl:ENSG00000012048|HPRD:00218|Vega:OTTHUMG00000157426 17 17q21 breast cancer 1, early onset protein-coding breast cancer 1, early onset Overexpression of miR-335 resulted in an upregulation of BRCA1 mRNA expression, suggesting a functional dominance of ID4 signaling. In summary, our data indicate that miR-335 affects different targets in the upstream BRCA1-regulatory cascade with impact on key cellular functions such as proliferation and apoptosis. 1645 miR-335 hsa-miR-335-5p,hsa-miR-335-3p MIMAT0000765,MIMAT0004703 miRNA MAPK1 apoptosis down Homo sapiens Acute lymphoblastic leukaemia cell 23888996 9606 5594 ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK HGNC:6871|MIM:176948|Ensembl:ENSG00000100030|HPRD:01496|Vega:OTTHUMG00000030508 22 22q11.21 mitogen-activated protein kinase 1 protein-coding mitogen-activated protein kinase 1 We show that exogenous expression of MIR335 in ALL cells increases sensitization to prednisolone-mediated apoptosis. Moreover, we demonstrate that MAPK1 is a novel target of MIR335, and that MEK/ERK inhibitor treatment enhanced prednisolone-induced cell death through the activation of BIM (BCL2L11). These results provide a possible underlying molecular mechanism to explain the association between reduced MIR335 with poor clinical outcome, and suggest that approaches to re-introduce MIR335 expression or override MAPK1 activity may offer promising therapeutic strategies in the treatment of ALL. 1646 miR-335 hsa-miR-335-5p,hsa-miR-335-3p MIMAT0000765,MIMAT0004703 miRNA SP1 apoptosis down Homo sapiens 23740614 9606 6667 - HGNC:11205|MIM:189906|Ensembl:ENSG00000185591|HPRD:01796|Vega:OTTHUMG00000170047 12 12q13.1 Sp1 transcription factor protein-coding Sp1 transcription factor These results indicated that upregulation of miR-335 can simultaneously suppress the invasiveness and promote apoptosis of lung cancer cell A549 and H1299 by targeting Bcl-w and SP1. 1647 miR-338 hsa-miR-338-3p,hsa-miR-338-5p MIMAT0004701,MIMAT0000763 miRNA NRP1 apoptosis down Homo sapiens gastric cancer cell 24736504 9606 8829 BDCA4|CD304|NP1|NRP|VEGF165R HGNC:8004|MIM:602069|Ensembl:ENSG00000099250|HPRD:03642|Vega:OTTHUMG00000019343 10 10p12 neuropilin 1 protein-coding neuropilin 1 Moreover, we found that miR-338 inhibited gastric cancer cell migration, invasion, proliferation and promoted apoptosis by targeting NRP1 expression. 1648 miR-338 hsa-miR-338-3p,hsa-miR-338-5p MIMAT0004701,MIMAT0000763 miRNA apoptosis Homo sapiens neuronal?cell 20574809 9606 Expression of MIR152, MIR200B, and MIR338 is specifically modulated in NB cell lines during differentiation and apoptosis. 1649 miR-338-3p hsa-miR-338-3p MIMAT0000763 miRNA AATK apoptosis down Homo sapiens neuronal?cell 22363537 9606 9625 AATYK|AATYK1|LMR1|LMTK1|PPP1R77|p35BP HGNC:21|MIM:605276|Ensembl:ENSG00000181409|HPRD:05591|Vega:OTTHUMG00000132717 17 17q25.3 apoptosis-associated tyrosine kinase protein-coding apoptosis-associated tyrosine kinase Thus, miR-338-3p may have the capacity to modulate AATK mRNA levels in neurons. Transfection of miR-338-3p mimics into rat B35 neuroblastoma cells resulted in a significant decrease of AATK mRNA levels, while the transfection of synthetic miR-338-5p mimics did not alter AATK levels. 1650 miR-338-3p hsa-miR-338-3p MIMAT0000763 miRNA HIF1A apoptosis down Homo sapiens HepG2/SMMC-772/Huh7 cell 25531114 9606 3091 HIF-1A|HIF-1alpha|HIF1|HIF1-ALPHA|MOP1|PASD8|bHLHe78 HGNC:4910|MIM:603348|Ensembl:ENSG00000100644|HPRD:04517|Vega:OTTHUMG00000140344 14 14q23.2 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) Overexpression of miR-338-3p inhibited HIF-1¦Á 3'-UTR luciferase activity and HIF-1¦Á protein levels in HepG2, SMMC-7721, and Huh7 cells. miR-338-3p significantly reduced cell viability and induced cell apoptosis of HCC cells. 1651 miR-338-3p hsa-miR-338-3p MIMAT0000763 miRNA PREX2 apoptosis down Homo sapiens gastric cancer cell 24375644 9606 80243 6230420N16Rik|DEP.2|DEPDC2|P-REX2|PPP1R129 HGNC:22950|MIM:612139|HPRD:13135 8 8q13.2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 protein-coding phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 Forced expression of miR-338-3p inhibited cell proliferation and clonogenicity and induced a G1-S arrest as well as apoptosis in gastric cancer cells. Furthermore, P-Rex2a (PREX2) was identified as a direct target of miR-338-3p, and silencing P-Rex2a resulted in the same biologic effects of miR-338-3p expression in gastric cancer cells. 1652 miR-338-3p hsa-miR-338-3p MIMAT0000763 miRNA RAB14 apoptosis down Homo sapiens NSCLC cell 25374067 9606 51552 FBP|RAB-14 HGNC:16524|MIM:612673|Ensembl:ENSG00000119396|HPRD:06693|Vega:OTTHUMG00000020582 9 9q32-q34.11 RAB14, member RAS oncogene family protein-coding RAB14, member RAS oncogene family Ectopic miR-338-3p expression significantly suppressed the in vitro proliferation and colony formation of NSCLC cells and enhanced apoptosis. Of note, ectopic miR-338-3p expression significantly inhibited Ras?related protein 14 (RAB14) mRNA and protein expression, and reduced luciferase reporter activity containing the RAB14 3'-untranslated region through the first binding site. 1653 miR-33a hsa-miR-33a-5p,hsa-miR-33a-3p MIMAT0000091,MIMAT0004506 miRNA TWIST1 apoptosis down Homo sapiens Saos-2 cell 24468065 9606 7291 ACS3|BPES2|BPES3|CRS|CRS1|SCS|TWIST|bHLHa38 HGNC:12428|MIM:601622|Ensembl:ENSG00000122691|HPRD:03374|Vega:OTTHUMG00000090821 7 7p21.2 twist family bHLH transcription factor 1 protein-coding twist family bHLH transcription factor 1 miR-33a is up-regulated in chemoresistant osteosarcoma and promotes osteosarcoma cell resistance to cisplatin by down-regulating TWIST. 1654 miR-33b hsa-miR-33b-5p,hsa-miR-33b-3p MIMAT0003301,MIMAT0004811 miRNA PIM1 apoptosis down Homo sapiens multiple myeloma cells 22983447 9606 5292 PIM HGNC:8986|MIM:164960|Ensembl:ENSG00000137193|HPRD:01292|Vega:OTTHUMG00000016426 6 6p21.2 Pim-1 proto-oncogene, serine/threonine kinase protein-coding Pim-1 proto-oncogene, serine/threonine kinase Examination of miR33b in patient multiple myeloma (MM) cells showed a constitutively low expression. Overexpression of miR33b decreased MM cell viability, migration, colony formation, and increased apoptosis and sensitivity of MM cells to MLN2238 treatment. In addition, overexpression of miR33b or MLN2238 exposure negatively regulated oncogene PIM-1 and blocked PIM-1 wild-type, but not PIM-1 mutant, luciferase activity. Moreover, PIM-1 overexpression led to significan abrogation of miR33b- or MLN2238-induced cell death. 1655 miR-34 hsa-miR-34a-5p,hsa-miR-34a-3p,hsa-miR-34b-5p,hsa-miR-34b-3p,hsa-miR-34c-5p,hsa-miR-34c-3p MIMAT0000255,MIMAT0004557,MIMAT0000685,MIMAT0000686,MIMAT0004676,MIMAT0004677 miRNA E2F1 apoptosis down Homo sapiens 23845991 9606 1869 E2F-1|RBAP1|RBBP3|RBP3 HGNC:3113|MIM:189971|Ensembl:ENSG00000101412|HPRD:01806|Vega:OTTHUMG00000032265 20 20q11.2 E2F transcription factor 1 protein-coding E2F transcription factor 1 Moreover, a comparison is given to reveal the subtle differences of the cell fate decision process between regulation and deregulation of miR34 on E2F1. It predicts that miR34 plays a critical role in promoting cell cycle arrest. In addition, a computer simulation result also predicts that the miR449 is necessary for apoptosis in response to sustained DNA damage. 1656 miR-34 hsa-miR-34a-5p,hsa-miR-34a-3p,hsa-miR-34b-5p,hsa-miR-34b-3p,hsa-miR-34c-5p,hsa-miR-34c-3p MIMAT0000255,MIMAT0004557,MIMAT0000685,MIMAT0000686,MIMAT0004676,MIMAT0004677 miRNA SIRT1 apoptosis down Homo sapiens 19221490 9606 23411 SIR2L1 HGNC:14929|MIM:604479|Ensembl:ENSG00000096717|HPRD:08381|Vega:OTTHUMG00000018340 10 10q21.3 sirtuin 1 protein-coding sirtuin 1 The miR-34 family regulates cell cycle progression, cellular senescence and apoptosis, but the targets of miR-34 are not completely defined. We recently found that miR-34a inhibits SIRT1, a gene that regulates cellular senescence and limits longevity. SIRT1 also regulates p53 dependent apoptosis through deacetylating and stabilizing p53. We also discovered that SIRT1 mediates miR-34a activation of apoptosis by regulating p53 activity. Based on this observation, we propose a positive feedback loop, in which p53 induces expression of miR-34a which suppresses SIRT1, increasing p53 activity. 1657 miR-34 hsa-miR-34a-5p,hsa-miR-34a-3p,hsa-miR-34b-5p,hsa-miR-34b-3p,hsa-miR-34c-5p,hsa-miR-34c-3p MIMAT0000255,MIMAT0004557,MIMAT0000685,MIMAT0000686,MIMAT0004676,MIMAT0004677 miRNA TP53 apoptosis Homo sapiens 17914404 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 MiR-34 activation can recapitulate elements of p53 activity, including induction of cell-cycle arrest and promotion of apoptosis, and loss of miR-34 can impair p53-mediated cell death. These data reinforce the growing awareness that non-coding RNAs are key players in tumour development by placing miRNAs in a central role in a well-known tumour-suppressor network. 1658 miR-34 hsa-miR-34a-5p,hsa-miR-34a-3p,hsa-miR-34b-5p,hsa-miR-34b-3p,hsa-miR-34c-5p,hsa-miR-34c-3p MIMAT0000255,MIMAT0004557,MIMAT0000685,MIMAT0000686,MIMAT0004676,MIMAT0004677 miRNA TP53 apoptosis Homo sapiens human tumors 18056431 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 When overexpressed, miR-34 leads to apoptosis or cellular senescence, whereas reduction of miR-34 function attenuates p53-mediated cell death. 1659 miR-34 hsa-miR-34a-5p,hsa-miR-34a-3p,hsa-miR-34b-5p,hsa-miR-34b-3p,hsa-miR-34c-5p,hsa-miR-34c-3p MIMAT0000255,MIMAT0004557,MIMAT0000685,MIMAT0000686,MIMAT0004676,MIMAT0004677 miRNA TP53 apoptosis Homo sapiens 19632201 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 MiR-34s have been characterized as direct p53 targets, which induce apoptosis, cell cycle arrest, and senescence. MiR-34s were found to associate with tumorigenesis. Thus far, there is no study on the role of MiR-34s in osteosarcoma. In the current study, we intensively investigated the function of MiR-34s in two osteosarcoma cell lines: U2OS (p53(+/+)) and SAOS-2 (p53(-/-)). We found that MiR-34s affect the expression of its target genes partially in a p53-dependent manner. And p53 also partially contributes to the MiR-34s induced cell cycle arrest and apoptosis. 1660 miR-34 hsa-miR-34a-5p,hsa-miR-34a-3p,hsa-miR-34b-5p,hsa-miR-34b-3p,hsa-miR-34c-5p,hsa-miR-34c-3p MIMAT0000255,MIMAT0004557,MIMAT0000685,MIMAT0000686,MIMAT0004676,MIMAT0004677 miRNA TP53 apoptosis Homo sapiens 24884974 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 MicroRNA-34 (miR-34) is directly regulated by p53, and its potential tumor suppressive roles have been studied extensively. As a p53-induced microRNA, miR-34 functions as a tumor suppressor by playing a role in cell cycle arrest, apoptosis and metabolic regulation. Among these p53/miR-34 associated processes, apoptosis and cell cycle arrest are known as essential for p53/miR-34-mediated tumor suppression. 1661 miR-34 hsa-miR-34a-5p,hsa-miR-34a-3p,hsa-miR-34b-5p,hsa-miR-34b-3p,hsa-miR-34c-5p,hsa-miR-34c-3p MIMAT0000255,MIMAT0004557,MIMAT0000685,MIMAT0000686,MIMAT0004676,MIMAT0004677 miRNA apoptosis Homo sapiens prostate cancer cells 18497571 9606 Only simultaneous inhibition or forced overexpression of both miR-34 resulted in modulation of DOX-mediated apoptosis. 1662 miR-34 hsa-miR-34a-5p,hsa-miR-34a-3p,hsa-miR-34b-5p,hsa-miR-34b-3p,hsa-miR-34c-5p,hsa-miR-34c-3p MIMAT0000255,MIMAT0004557,MIMAT0000685,MIMAT0000686,MIMAT0004676,MIMAT0004677 miRNA apoptosis Homo sapiens 23834144 9606 Recently, microRNAs (miRNAs) including miR-34 family have been found to play a critical role in tumorigenesis through regulating the expression of its target genes, which are involved in many cellular processes such as cell proliferation, survival, apoptosis, migration, invasion and angiogenesis. 1663 miR-340 hsa-miR-340-5p,hsa-miR-340-3p MIMAT0004692,MIMAT0000750 miRNA CDKN1B apoptosis down Homo sapiens non-small cell lung cancer 25151966 9606 1027 CDKN4|KIP1|MEN1B|MEN4|P27KIP1 HGNC:1785|MIM:600778|Ensembl:ENSG00000111276|HPRD:02867|Vega:OTTHUMG00000149914 12 12p13.1-p12 cyclin-dependent kinase inhibitor 1B (p27, Kip1) protein-coding cyclin-dependent kinase inhibitor 1B (p27, Kip1) MiR-340 inhibits tumor cell proliferation and induces apoptosis by targeting multiple negative regulators of p27 in non-small cell lung cancer. Therefore, miR-340 controls p27 at both translational and posttranslational levels. Accordingly, the inhibition of either PUM1 or SKP2 partially recapitulates the miR-340 effect on cell proliferation and apoptosis. 1664 miR-340 hsa-miR-340-5p,hsa-miR-340-3p MIMAT0004692,MIMAT0000750 miRNA PUM1 apoptosis up Homo sapiens non-small cell lung cancer 25151966 9606 9698 HSPUM|PUMH|PUMH1|PUML1 HGNC:14957|MIM:607204|Ensembl:ENSG00000134644|HPRD:06230|Vega:OTTHUMG00000003795 1 1p35.2 pumilio RNA-binding family member 1 protein-coding pumilio RNA-binding family member 1 MiR-340 inhibits tumor cell proliferation and induces apoptosis by targeting multiple negative regulators of p27 in non-small cell lung cancer. 1665 miR-340 hsa-miR-340-5p,hsa-miR-340-3p MIMAT0004692,MIMAT0000750 miRNA PUM2 apoptosis up Homo sapiens non-small cell lung cancer 25151966 9606 23369 PUMH2|PUML2 HGNC:14958|MIM:607205|Ensembl:ENSG00000055917|HPRD:09527|Vega:OTTHUMG00000122098 2 2p22-p21 pumilio RNA-binding family member 2 protein-coding pumilio RNA-binding family member 2 MiR-340 inhibits tumor cell proliferation and induces apoptosis by targeting multiple negative regulators of p27 in non-small cell lung cancer. 1666 miR-340 hsa-miR-340-5p,hsa-miR-340-3p MIMAT0004692,MIMAT0000750 miRNA SKP2 apoptosis Homo sapiens non-small cell lung cancer 25151966 9606 6502 FBL1|FBXL1|FLB1|p45 HGNC:10901|MIM:601436|Ensembl:ENSG00000145604|HPRD:03256|Vega:OTTHUMG00000131106 5 5p13 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase protein-coding S-phase kinase-associated protein 2, E3 ubiquitin protein ligase MiR-340 inhibits tumor cell proliferation and induces apoptosis by targeting multiple negative regulators of p27 in non-small cell lung cancer. 1667 miR-342 hsa-miR-342-3p,hsa-miR-342-5p MIMAT0004694,MIMAT0000753 miRNA ESR1 apoptosis up Homo sapiens breast cancer cell 23408138 9606 2099 ER|ESR|ESRA|ESTRR|Era|NR3A1 HGNC:3467|MIM:133430|Ensembl:ENSG00000091831|HPRD:00589|Vega:OTTHUMG00000016103 6 6q25.1 estrogen receptor 1 protein-coding estrogen receptor 1 The expression levels of miR-342 and ER¦Á mRNA were analyzed in human breast cancer samples and cell lines by quantitative reverse transcription (RT)-PCR analysis. Statistically significant associations were observed between miR-342 and ER, HER2 and vascular endothelial growth factor (VEGF) status in the human breast cancer samples and the levels of miR-342 gradually increased as ER¦Á mRNA expression increased. Moreover, ectopic overexpression of miR-342 upregulated the expression levels of the ER¦Á mRNA and significantly sensitized the MCF-7 cells to tamoxifen-induced apoptosis and inhibition of cellular proliferation. 1668 miR-342 hsa-miR-342-5p,hsa-miR-342-3p MIMAT0004694,MIMAT0000753 miRNA apoptosis Homo sapiens colorectal cancer cells 18264139 9606 Reconstitution of hsa-miR-342 in the colorectal cancer cell line HT-29 induced apoptosis, suggesting that this microRNA could function as a proapoptotic tumor suppressor. 1669 miR-342 hsa-miR-342-5p,hsa-miR-342-3p MIMAT0004694,MIMAT0000753 miRNA apoptosis Homo sapiens T-cell lymphoma 20448109 9606 The down-regulation of intronically encoded miR-342 plays a role in the pathogenesis of SzS by inhibiting apoptosis, and describe a novel mechanism of regulation for this microRNA via binding of miR-199a* to its host gene. 1670 miR-342 hsa-miR-342-5p,hsa-miR-342-3p MIMAT0004694,MIMAT0000753 miRNA apoptosis Homo sapiens breast?cell 21172025 9606 In addition, our results suggest that miR-342 regulates expression of genes involved in tamoxifen mediated tumor cell apoptosis and cell cycle progression. R 1671 miR-342-3p hsa-miR-342-3p MIMAT0000753 miRNA apoptosis Homo sapiens breast cancer cell 24921394 9606 The expressions of miRNA-342-3p in TNBC tissue of CR were higher than those of PR. The cell growth rates of mimic were lower and cell apoptosis rates were higher than those of min- NC after cultivating with paclitaxel or cisplatin for 48 h, with significant difference (P<0.05). 1672 miR-345 hsa-miR-345-5p,hsa-miR-345-3p MIMAT0000772,MIMAT0022698 miRNA BAG3 apoptosis Homo sapiens 21665895 9606 9531 BAG-3|BIS|CAIR-1|MFM6 HGNC:939|MIM:603883|Ensembl:ENSG00000151929|HPRD:04860|Vega:OTTHUMG00000019155 10 10q25.2-q26.2 BCL2-associated athanogene 3 protein-coding BCL2-associated athanogene 3 Furthermore, we identified BCL2-associated athanogene 3 (BAG3), an anti-apoptosis protein, to be a target of mir-345. These results suggested as a methylation-sensitive miRNA in CRC, mir-345 may play an important role of antineoplastic as a growth inhibitor in the development of CRC. 1673 miR-345 hsa-miR-345-5p,hsa-miR-345-3p MIMAT0000772,MIMAT0022698 miRNA CDKN1A apoptosis down Homo sapiens hepato cellular carcinoma cells 23577194 9606 1026 CAP20|CDKN1|CIP1|MDA-6|P21|SDI1|WAF1|p21CIP1 HGNC:1784|MIM:116899|Ensembl:ENSG00000124762|HPRD:00298|Vega:OTTHUMG00000014603 6 6p21.2 cyclin-dependent kinase inhibitor 1A (p21, Cip1) protein-coding cyclin-dependent kinase inhibitor 1A (p21, Cip1) HCV core-induced microRNA-345 suppressed p21(Waf1/Cip1) gene expression through targeting its 3' untranslated region in human hepatoma cells. Moreover, the core protein inhibited curcumin-induced apoptosis through p21(Waf1/Cip1)-targeting microRNA-345 in Huh7 cells. 1674 miR-346 hsa-miR-346 MIMAT0000773 miRNA VDR apoptosis down Homo sapiens bowel 25192497 9606 7421 NR1I1|PPP1R163 HGNC:12679|MIM:601769|Ensembl:ENSG00000111424|HPRD:03463|Vega:OTTHUMG00000169890 12 12q13.11 vitamin D (1,25- dihydroxyvitamin D3) receptor protein-coding vitamin D (1,25- dihydroxyvitamin D3) receptor We recently reported that the gut epithelial vitamin D receptor (VDR) signaling inhibits colitis through inhibition of intestinal epithelial cell apoptosis, and the level of colonic epithelial VDR is markedly reduced in patients with inflammatory bowel diseases (IBD). VDR downregulation promotes colitis, but the mechanism underlying VDR downregulation in IBD is unknown. e showed that tumor necrosis factor ¦Á (TNF-¦Á) suppresses VDR expression while simultaneously upregulating miR-346 in human colon cancer cells. Further studies demonstrated that miR-346 inhibits VDR by a specific target sequence in the 3' untranslated region of the human VDR transcript, and blockade of miR-346 with a hairpin inhibitor abrogates the ability of TNF-¦Á to inhibit VDR, confirming that TNF-¦Á downregulates VDR by inducing miR-346. 1675 miR-346 hsa-miR-346 MIMAT0000773 miRNA VDR apoptosis Homo sapiens gut cell 25603468 9606 7421 NR1I1|PPP1R163 HGNC:12679|MIM:601769|Ensembl:ENSG00000111424|HPRD:03463|Vega:OTTHUMG00000169890 12 12q13.11 vitamin D (1,25- dihydroxyvitamin D3) receptor protein-coding vitamin D (1,25- dihydroxyvitamin D3) receptor On the one hand, intestinal epithelial VDR signaling protects the integrity of the mucosal barrier by inhibiting inflammation-induced epithelial cell apoptosis. This barrier-protecting, anti-colitic activity is independent of the non-epithelial immune VDR actions. A healthy and intact mucosal barrier prevents bacterial invasion and thus reduces mucosal inflammation. On the other hand, inflammation in turn down-regulates epithelial VDR expression by inducing VDR-targeting microRNA-346, thus compromising mucosal barrier functions. 1676 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA ALDH2 apoptosis down Homo sapiens myocardial infarction 23323620 9606 217 ALDH-E2|ALDHI|ALDM HGNC:404|MIM:100650|Ensembl:ENSG00000111275|HPRD:00003|Vega:OTTHUMG00000169603 12 12q24.2 aldehyde dehydrogenase 2 family (mitochondrial) protein-coding aldehyde dehydrogenase 2 family (mitochondrial) In 293 cells, luciferase reporter assay results demonstrated that ALDH2 was a direct target of miR-34a. 1677 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA ARHGDIB apoptosis down Homo sapiens NSCLC cell lines 23349340 9606 397 D4|GDIA2|GDID4|LYGDI|Ly-GDI|RAP1GN1|RhoGDI2 HGNC:679|MIM:602843|Ensembl:ENSG00000111348|HPRD:04162|Vega:OTTHUMG00000168742 12 12p12.3 Rho GDP dissociation inhibitor (GDI) beta protein-coding Rho GDP dissociation inhibitor (GDI) beta Interestingly, LyGDI was discovered as a new target gene of miR-34a, and downregulation of LyGDI promoted Rac1 activation and membrane translocation, resulting in cell apoptosis. 1678 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA BCL2 apoptosis Homo sapiens colon cancer cells 17656095 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 apoptosis regulator Bcl-2 Using gene-expression analyses, reporter gene assays, and chromatin-immunoprecipitation approaches, we present definitive evidence that the abundance of the three-member miRNA34 family is directly regulated by p53 in cell lines and tissues. Using array-based approaches and algorithm predictions, we define genes likely to be directly regulated by miRNA34, with cell-cycle regulatory genes being the most prominent class. In addition, we provide functional evidence, obtained via antisense oligonucleotide transfection and the use of mouse embryonic stem cells with loss of miRNA34a function, that the BCL2 protein is regulated directly by miRNA34. 1679 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA BCL2 apoptosis Homo sapiens neuroblastoma 18505919 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 BCL2 and MYCN were identified as miR-34a targets and likely mediators of the tumor suppressor phenotypic effect. 1680 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA BCL2 apoptosis down Homo sapiens nonsmall cell lung cancer cells 22438124 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Our findings suggest that delta-tocotrienol is a nontoxic activator of mir-34a which can inhibit NSCLC cell proliferation, induce apoptosis and inhibit invasion, and thus offering a potential starting point for the design of novel anticancer agents. Furthermore, cellular mechanism studies revealed that induction of miR-34a decreased the expression of Notch-1 and its downstream targets including Hes-1, Cyclin D1, Survivin and Bcl-2. 1681 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA BCL2 apoptosis down Homo sapiens breast cancer cell 22623155 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Ectopic restoration of miR-34a in breast cancer cells suppressed cells proliferation, invasion, and induced apoptosis. Bcl-2 and SIRT1 as the targets of miR-34a were found to be in reverse correlation with ectopic expression of miR-34a. 1682 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA BCL2 apoptosis up Homo sapiens multiple myeloma cells 23035210 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Either transient expression of miR-34a synthetic mimics or lentivirus-based miR-34a-stable enforced expression triggered growth inhibition and apoptosis in MM cells in vitro. Synthetic miR-34a downregulated canonic targets BCL2, CDK6, and NOTCH1 at both the mRNA and protein level. 1683 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA BCL2 apoptosis down Homo sapiens PANC-1 cell lines 23298779 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 miR-34a remarkably induced cell cycle arrest and apoptosis, suppressed the tumor cell migration and inhibited the target gene expressions such as E2F3, Bcl-2, c-myc and cyclin D1. 1684 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA BCL2 apoptosis down Homo sapiens neuron 23948100 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 miR-34a directly inhibits Bcl2 and XIAP, both anti-apoptotic proteins. 1685 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA BIRC5 apoptosis down Homo sapiens nonsmall cell lung cancer cells 22438124 9606 332 API4|EPR-1 HGNC:593|MIM:603352|Ensembl:ENSG00000089685|HPRD:04520|Vega:OTTHUMG00000177505 17 17q25 baculoviral IAP repeat containing 5 protein-coding baculoviral IAP repeat containing 5 Our findings suggest that delta-tocotrienol is a nontoxic activator of mir-34a which can inhibit NSCLC cell proliferation, induce apoptosis and inhibit invasion, and thus offering a potential starting point for the design of novel anticancer agents. Furthermore, cellular mechanism studies revealed that induction of miR-34a decreased the expression of Notch-1 and its downstream targets including Hes-1, Cyclin D1, Survivin and Bcl-2. 1686 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA CASP2 apoptosis down Homo sapiens normal human hepatocytes and human intrahepatic biliary epithelial cells 22841474 9606 835 CASP-2|ICH1|NEDD-2|NEDD2|PPP1R57 HGNC:1503|MIM:600639|Ensembl:ENSG00000106144|HPRD:02800|Vega:OTTHUMG00000023641 7 7q34-q35 caspase 2, apoptosis-related cysteine peptidase protein-coding caspase 2, apoptosis-related cysteine peptidase Overexpression of miR-34a decreased ethanol-induced apoptosis in both N-Heps and HiBECs.A combination of bioinformatics, dual-luciferase reporter assay, mass spectrometry, and Western blot analysis revealed that caspase-2 and sirtuin 1 are the direct targets of miR-34a. 1687 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA CCND1 apoptosis down Homo sapiens nonsmall cell lung cancer cells 22438124 9606 595 BCL1|D11S287E|PRAD1|U21B31 HGNC:1582|MIM:168461|Ensembl:ENSG00000110092|HPRD:01346|Vega:OTTHUMG00000167877 11 11q13 cyclin D1 protein-coding cyclin D1 Our findings suggest that delta-tocotrienol is a nontoxic activator of mir-34a which can inhibit NSCLC cell proliferation, induce apoptosis and inhibit invasion, and thus offering a potential starting point for the design of novel anticancer agents. Furthermore, cellular mechanism studies revealed that induction of miR-34a decreased the expression of Notch-1 and its downstream targets including Hes-1, Cyclin D1, Survivin and Bcl-2. 1688 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA CCND1 apoptosis down Homo sapiens PANC-1 cell lines 23298779 9606 595 BCL1|D11S287E|PRAD1|U21B31 HGNC:1582|MIM:168461|Ensembl:ENSG00000110092|HPRD:01346|Vega:OTTHUMG00000167877 11 11q13 cyclin D1 protein-coding cyclin D1 miR-34a remarkably induced cell cycle arrest and apoptosis, suppressed the tumor cell migration and inhibited the target gene expressions such as E2F3, Bcl-2, c-myc and cyclin D1. 1689 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA CDK6 apoptosis up Homo sapiens multiple myeloma cells 23035210 9606 1021 PLSTIRE HGNC:1777|MIM:603368|Ensembl:ENSG00000105810|HPRD:04533|Vega:OTTHUMG00000131697 7 7q21-q22 cyclin-dependent kinase 6 protein-coding cyclin-dependent kinase 6 Either transient expression of miR-34a synthetic mimics or lentivirus-based miR-34a-stable enforced expression triggered growth inhibition and apoptosis in MM cells in vitro. Synthetic miR-34a downregulated canonic targets BCL2, CDK6, and NOTCH1 at both the mRNA and protein level. 1690 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA CDKN1A apoptosis down Homo sapiens 21177782 9606 1026 CAP20|CDKN1|CIP1|MDA-6|P21|SDI1|WAF1|p21CIP1 HGNC:1784|MIM:116899|Ensembl:ENSG00000124762|HPRD:00298|Vega:OTTHUMG00000014603 6 6p21.2 cyclin-dependent kinase inhibitor 1A (p21, Cip1) protein-coding cyclin-dependent kinase inhibitor 1A (p21, Cip1) We demonstrate that miR-34a directly targets the 3' untranslated regions of MAGE-A genes and decreases MAGE-A protein levels. This decrease in MAGE-A results in a concomitant increase in p53 and its associated transcriptional targets, p21/WAF1/CIP1 and, importantly, miR-34a. 1691 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA E2F3 apoptosis down Homo sapiens PANC-1 cell lines 23298779 9606 1871 E2F-3 HGNC:3115|MIM:600427|Ensembl:ENSG00000112242|HPRD:02693|Vega:OTTHUMG00000016389 6 6p22 E2F transcription factor 3 protein-coding E2F transcription factor 3 miR-34a remarkably induced cell cycle arrest and apoptosis, suppressed the tumor cell migration and inhibited the target gene expressions such as E2F3, Bcl-2, c-myc and cyclin D1. 1692 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA FASLG apoptosis Homo sapiens rheumatoid arthritis synovial fibroblasts 22161761 9606 356 ALPS1B|APT1LG1|APTL|CD178|CD95-L|CD95L|FASL|TNFSF6 HGNC:11936|MIM:134638|Ensembl:ENSG00000117560|HPRD:00610|Vega:OTTHUMG00000034841 1 1q23 Fas ligand (TNF superfamily, member 6) protein-coding Fas ligand (TNF superfamily, member 6) Enforced expression of miR-34a* led to an increased rate of FasL- and TRAIL-mediated apoptosis in RASFs. Moreover, levels of miR-34a* were highly correlated with expression of XIAP, which was found to be up-regulated in RA synovial cells. Finally, we identified XIAP as a direct target of miR-34a*. 1693 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA GCG apoptosis Homo sapiens INS-1 cell 23217387 9606 2641 GLP1|GLP2|GRPP HGNC:4191|MIM:138030|Ensembl:ENSG00000115263|HPRD:00676|Vega:OTTHUMG00000153892 2 2q36-q37 glucagon protein-coding glucagon A 24-hours incubation of INS-1 cells with palmitate significantly decreased cell viability, increased cell apoptosis and led to the activation of microRNA-34a and the suppression of sirtuin 1. A co-incubation with GLP-1 protected the cells against palmitate-induced toxicity in association with a reduction in palmitate-induced activation of microRNA-34a. Furthermore, palmitate-induced apoptosis was significantly increased in cells that were infected with microRNA-34a mimics and decreased in cells that were infected with microRNA-34a inhibitors. 1694 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA HES1 apoptosis down Homo sapiens nonsmall cell lung cancer cells 22438124 9606 3280 HES-1|HHL|HRY|bHLHb39 HGNC:5192|MIM:139605|Ensembl:ENSG00000114315|HPRD:00770|Vega:OTTHUMG00000155984 3 3q28-q29 hes family bHLH transcription factor 1 protein-coding hes family bHLH transcription factor 1 Our findings suggest that delta-tocotrienol is a nontoxic activator of mir-34a which can inhibit NSCLC cell proliferation, induce apoptosis and inhibit invasion, and thus offering a potential starting point for the design of novel anticancer agents. Furthermore, cellular mechanism studies revealed that induction of miR-34a decreased the expression of Notch-1 and its downstream targets including Hes-1, Cyclin D1, Survivin and Bcl-2. 1695 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA HOTAIR apoptosis down Homo sapiens PC3 and DU145 PCa cells 23936419 9606 100124700 HOXAS|HOXC-AS4|HOXC11-AS1|NCRNA00072 HGNC:33510|MIM:611400|Ensembl:ENSG00000228630 12 12q13.13 HOX transcript antisense RNA ncRNA HOX transcript antisense RNA Knockdown (siRNA) of HOTAIR decreased PCa cell proliferation, migration and invasion and induced apoptosis and cell cycle arrest. miR-34a was also up-regulated by genistein and may directly target HOTAIR in both PC3 and DU145 PCa cells 1696 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA KLF4 apoptosis Homo sapiens CD34+ cell 21211043 9606 9314 EZF|GKLF HGNC:6348|MIM:602253|Ensembl:ENSG00000136826|Vega:OTTHUMG00000020449 9 9q31 Kruppel-like factor 4 (gut) protein-coding Kruppel-like factor 4 (gut) Especially, miR-34a was markedly overexpressed in 5q- patients, suggesting its role in an increased apoptosis of bone marrow progenitors. Out of four miRNAs at del(5q), only miR-378 and miR-146a showed reduced gene expression in the patients. An integrative analysis of mRNA profiles and predicted putative targets defined potential downstream targets of the deregulated miRNAs. The list of targets included several genes that play an important role in the regulation of hematopoiesis (e.g. KLF4, LEF1, SPI1). 1697 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA LEF1 apoptosis Homo sapiens CD34+ cell 21211043 9606 51176 LEF-1|TCF10|TCF1ALPHA|TCF7L3 HGNC:6551|MIM:153245|Ensembl:ENSG00000138795|HPRD:01075|Vega:OTTHUMG00000131809 4 4q23-q25 lymphoid enhancer-binding factor 1 protein-coding lymphoid enhancer-binding factor 1 Especially, miR-34a was markedly overexpressed in 5q- patients, suggesting its role in an increased apoptosis of bone marrow progenitors. Out of four miRNAs at del(5q), only miR-378 and miR-146a showed reduced gene expression in the patients. An integrative analysis of mRNA profiles and predicted putative targets defined potential downstream targets of the deregulated miRNAs. The list of targets included several genes that play an important role in the regulation of hematopoiesis (e.g. KLF4, LEF1, SPI1). 1698 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA MAGEA1 apoptosis down Homo sapiens 21177782 9606 4100 CT1.1|MAGE1 HGNC:6796|MIM:300016|Ensembl:ENSG00000198681|HPRD:02059|Vega:OTTHUMG00000024192 X Xq28 melanoma antigen family A, 1 (directs expression of antigen MZ2-E) protein-coding melanoma antigen family A, 1 (directs expression of antigen MZ2-E) We demonstrate that miR-34a directly targets the 3' untranslated regions of MAGE-A genes and decreases MAGE-A protein levels. This decrease in MAGE-A results in a concomitant increase in p53 and its associated transcriptional targets, p21/WAF1/CIP1 and, importantly, miR-34a. 1699 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA MYC apoptosis down Homo sapiens PANC-1 cell lines 23298779 9606 4609 MRTL|MYCC|bHLHe39|c-Myc HGNC:7553|MIM:190080|Ensembl:ENSG00000136997|HPRD:01818|Vega:OTTHUMG00000128475 8 8q24.21 v-myc avian myelocytomatosis viral oncogene homolog protein-coding v-myc avian myelocytomatosis viral oncogene homolog miR-34a remarkably induced cell cycle arrest and apoptosis, suppressed the tumor cell migration and inhibited the target gene expressions such as E2F3, Bcl-2, c-myc and cyclin D1. 1700 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA MYCN apoptosis Homo sapiens neuroblastoma 18505919 9606 4613 MODED|N-myc|NMYC|ODED|bHLHe37 HGNC:7559|MIM:164840|Ensembl:ENSG00000134323|HPRD:01278|Vega:OTTHUMG00000039579 2 2p24.3 v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog protein-coding v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog BCL2 and MYCN were identified as miR-34a targets and likely mediators of the tumor suppressor phenotypic effect. 1701 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA NOTCH1 apoptosis down Homo sapiens nonsmall cell lung cancer cells 22438124 9606 4851 TAN1|hN1 HGNC:7881|MIM:190198|Ensembl:ENSG00000148400|HPRD:01827|Vega:OTTHUMG00000020935 9 9q34.3 notch 1 protein-coding notch 1 Our findings suggest that delta-tocotrienol is a nontoxic activator of mir-34a which can inhibit NSCLC cell proliferation, induce apoptosis and inhibit invasion, and thus offering a potential starting point for the design of novel anticancer agents. Furthermore, cellular mechanism studies revealed that induction of miR-34a decreased the expression of Notch-1 and its downstream targets including Hes-1, Cyclin D1, Survivin and Bcl-2. 1702 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA PDGFRA apoptosis down Homo sapiens lung tumor cells 23805317 9606 5156 CD140A|PDGFR-2|PDGFR2|RHEPDGFRA HGNC:8803|MIM:173490|Ensembl:ENSG00000134853|HPRD:01429|Vega:OTTHUMG00000128699 4 4q12 platelet-derived growth factor receptor, alpha polypeptide protein-coding platelet-derived growth factor receptor, alpha polypeptide MiR-34a/c-Dependent PDGFR-¦Á/¦Â Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer. miR-34a/c overexpression or downregulation of PDGFR-¦Á/¦Â by siRNAs, strongly augmented the response to TNF-related apoptosis inducing ligand (TRAIL) while reducing migratory and invasive capacity of NSCLC cells.we found that miR-34a and miR-34c target platelet-derived growth factor receptor alpha and beta (PDGFR-¦Á and PDGFR-¦Â), cell surface tyrosine kinase receptors that induce proliferation, migration and invasion in cancer.Moreover, we identified an inverse correlation between PDGFR-¦Á/¦Â and miR-34a/c expression in lung tumor samples. 1703 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA PDGFRB apoptosis down Homo sapiens 23805317 9606 5159 CD140B|IBGC4|IMF1|JTK12|PDGFR|PDGFR-1|PDGFR1 HGNC:8804|MIM:173410|Ensembl:ENSG00000113721|HPRD:01423|Vega:OTTHUMG00000130053 5 5q33.1 platelet-derived growth factor receptor, beta polypeptide protein-coding platelet-derived growth factor receptor, beta polypeptide MiR-34a/c-Dependent PDGFR-¦Á/¦Â Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer. miR-34a/c overexpression or downregulation of PDGFR-¦Á/¦Â by siRNAs, strongly augmented the response to TNF-related apoptosis inducing ligand (TRAIL) while reducing migratory and invasive capacity of NSCLC cells.we found that miR-34a and miR-34c target platelet-derived growth factor receptor alpha and beta (PDGFR-¦Á and PDGFR-¦Â), cell surface tyrosine kinase receptors that induce proliferation, migration and invasion in cancer.Moreover, we identified an inverse correlation between PDGFR-¦Á/¦Â and miR-34a/c expression in lung tumor samples. 1704 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0004557,MIMAT0000255 miRNA PRIMA1 apoptosis down Homo sapiens lung cancer cell 19921694 9606 145270 PRIMA HGNC:18319|MIM:613851|Ensembl:ENSG00000175785|HPRD:17907|Vega:OTTHUMG00000141313 14 14q32.12 proline rich membrane anchor 1 protein-coding proline rich membrane anchor 1 TaqMan microRNA assay showed that the expression of microRNA-34a was increased in the H211 and H1155 cells posttreatment. Knockdown microRNA-34a decreased the rate of apoptosis caused by PRIMA-1. The above results suggest that microRNA-34a is one of the important components of PRIMA-1-induced apoptotic network in the cancer cells harboring mutant p53. 1705 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA SIRT1 apoptosis down Homo sapiens endothelial progenitor cells 20424141 9606 23411 SIR2L1 HGNC:14929|MIM:604479|Ensembl:ENSG00000096717|HPRD:08381|Vega:OTTHUMG00000018340 10 10q21.3 sirtuin 1 protein-coding sirtuin 1 NAD-dependent deacetylase MiR-34a, recently reported as a tumor suppressor, hsa been found to target silent information regulator 1 (sirt1), leading to cell cycle arrest or apoptosis. MiR-34a overexpression led to a significantly increased EPC senescence, paralleled with an approximately 40% Sirt1 reduction. 1706 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA SIRT1 apoptosis down Homo sapiens breast cancer cell 22623155 9606 23411 SIR2L1 HGNC:14929|MIM:604479|Ensembl:ENSG00000096717|HPRD:08381|Vega:OTTHUMG00000018340 10 10q21.3 sirtuin 1 protein-coding sirtuin 1 Ectopic restoration of miR-34a in breast cancer cells suppressed cells proliferation, invasion, and induced apoptosis. Bcl-2 and SIRT1 as the targets of miR-34a were found to be in reverse correlation with ectopic expression of miR-34a. 1707 miR-34a hsa-miR-34a-5p,hsa-miR-34a-4p MIMAT0000255,MIMAT0004558 miRNA SIRT1 apoptosis down Homo sapiens normal human hepatocytes and human intrahepatic biliary epithelial cells 22841474 9606 23411 SIR2L1 HGNC:14929|MIM:604479|Ensembl:ENSG00000096717|HPRD:08381|Vega:OTTHUMG00000018340 10 10q21.3 sirtuin 1 protein-coding sirtuin 1 Overexpression of miR-34a decreased ethanol-induced apoptosis in both N-Heps and HiBECs.A combination of bioinformatics, dual-luciferase reporter assay, mass spectrometry, and Western blot analysis revealed that caspase-2 and sirtuin 1 are the direct targets of miR-34a. 1708 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0004557,MIMAT0000255 miRNA SIRT1 apoptosis down Homo sapiens INS-1 cell 23217387 9606 23411 SIR2L1 HGNC:14929|MIM:604479|Ensembl:ENSG00000096717|HPRD:08381|Vega:OTTHUMG00000018340 10 10q21.3 sirtuin 1 protein-coding sirtuin 1 A 24-hours incubation of INS-1 cells with palmitate significantly decreased cell viability, increased cell apoptosis and led to the activation of microRNA-34a and the suppression of sirtuin 1. A co-incubation with GLP-1 protected the cells against palmitate-induced toxicity in association with a reduction in palmitate-induced activation of microRNA-34a. Furthermore, palmitate-induced apoptosis was significantly increased in cells that were infected with microRNA-34a mimics and decreased in cells that were infected with microRNA-34a inhibitors. 1709 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA SPI1 apoptosis Homo sapiens CD34+ cell 21211043 9606 6688 OF|PU.1|SFPI1|SPI-1|SPI-A HGNC:11241|MIM:165170|Ensembl:ENSG00000066336|HPRD:01305|Vega:OTTHUMG00000150150 11 11p11.2 Spi-1 proto-oncogene protein-coding Spi-1 proto-oncogene Especially, miR-34a was markedly overexpressed in 5q- patients, suggesting its role in an increased apoptosis of bone marrow progenitors. Out of four miRNAs at del(5q), only miR-378 and miR-146a showed reduced gene expression in the patients. An integrative analysis of mRNA profiles and predicted putative targets defined potential downstream targets of the deregulated miRNAs. The list of targets included several genes that play an important role in the regulation of hematopoiesis (e.g. KLF4, LEF1, SPI1). 1710 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA TNFSF10 apoptosis Homo sapiens rheumatoid arthritis synovial fibroblasts 22161761 9606 8743 APO2L|Apo-2L|CD253|TL2|TRAIL HGNC:11925|MIM:603598|Ensembl:ENSG00000121858|HPRD:04670|Vega:OTTHUMG00000156917 3 3q26 tumor necrosis factor (ligand) superfamily, member 10 protein-coding tumor necrosis factor (ligand) superfamily, member 10 Enforced expression of miR-34a* led to an increased rate of FasL- and TRAIL-mediated apoptosis in RASFs. Moreover, levels of miR-34a* were highly correlated with expression of XIAP, which was found to be up-regulated in RA synovial cells. Finally, we identified XIAP as a direct target of miR-34a*. 1711 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA TP53 apoptosis Homo sapiens pancreatic cancer cells 17540599 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. 1712 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA TP53 apoptosis Homo sapiens tumor cells 17554199 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest. 1713 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA TP53 apoptosis Homo sapiens colon cancer cells 17656095 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 apoptosis regulator Bcl-2 Using gene-expression analyses, reporter gene assays, and chromatin-immunoprecipitation approaches, we present definitive evidence that the abundance of the three-member miRNA34 family is directly regulated by p53 in cell lines and tissues. 1714 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA TP53 apoptosis Homo sapiens pancreatic beta-cell 18633110 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 MiR34a rise is linked to activation of p53 and results in sensitization to apoptosis and impaired nutrient-induced secretion. The latter effect is associated with inhibition of the expression of vesicle-associated membrane protein 2, a key player in beta-cell exocytosis. Higher miR146 levels do not affect the capacity to release insulin but contribute to increased apoptosis. Treatment with oligonucleotides that block miR34a or miR146 activity partially protects palmitate-treated cells from apoptosis but is insufficient to restore normal secretion. 1715 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA TP53 apoptosis Homo sapiens malignant peripheral nerve sheath tumour cells 19890883 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 cell division protein kin In vitro studies using the cell lines MPNST-14 (NF1 mutant) and MPNST-724 (from a non-NF1 individual) show that exogenous expression of p53 or miR-34a promotes apoptotic cell death. In addition, exogenous expression of p53 in MPNST cells induces miR-34a and other miRNAs. 1716 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA TP53 apoptosis up Homo sapiens chronic lymphocytic leukemia cells 20581456 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 Knockdown of p53 in HCT-116 cells severely reduces miR-34a induced apoptosis. 1717 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA TP53 apoptosis up Homo sapiens 21177782 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 We demonstrate that miR-34a directly targets the 3' untranslated regions of MAGE-A genes and decreases MAGE-A protein levels. This decrease in MAGE-A results in a concomitant increase in p53 and its associated transcriptional targets, p21/WAF1/CIP1 and, importantly, miR-34a. 1718 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA TP53 apoptosis down Homo sapiens acute myeloid leukemia cell 22810507 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 Profiling microRNA (miRNA) expression delineated TP53 alteration-associated miRNA profiles, and identified miR-34a and miR-100 as the most significantly down- and upregulated miRNA, respectively. 1719 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA TP53 apoptosis up Homo sapiens epithelial cells 22898888 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 Epithelial cells upregulated the expression of p53, which was subsequently specifically phosphorylated, massively activated p38 and initiated mitochondrial, caspase-dependent apoptosis. These events occurred in the presence of moderately increased expression of miR-34a only. 1720 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA TP53 apoptosis down Homo sapiens glioblastoma cell line cells 23155233 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 A172 glioblastoma cells, expressing wild-type p53 were irradiated to a total dose of up to 60 Gy allowing us to analyze the activities of apoptosis-related proteins.The high miR-34a expression level in the cells after irradiation at 60 Gy reduced the p53 expression level. 1721 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA TP53 apoptosis Homo sapiens liver cancer 25053820 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 MiR34a is a tumor-suppressor miRNA that functions within the p53 pathway to regulate cell-cycle progression and apoptosis. 1722 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA UFC1 apoptosis down Homo sapiens hepatocellular carcinoma cell 25449213 9606 51506 HSPC155 HGNC:26941|MIM:610554|Ensembl:ENSG00000143222|HPRD:15643|Vega:OTTHUMG00000033155 1 1q23.3 ubiquitin-fold modifier conjugating enzyme 1 protein-coding ubiquitin-fold modifier conjugating enzyme 1 Transgenic expression of the lincRNA-UFC1 in HCC cells promoted their proliferation and cell-cycle progression and inhibited apoptosis, whereas short hairpin RNA knockdown of lincRNA-UFC1 had opposite effects. Tumors grown from lincRNA-UFC1 knockdown were smaller than controls. The lincRNA-UFC1 interacted directly with the messenger RNA (mRNA) stabilizing protein HuR (encoded by ELAVL1) to increase levels of ¦Â-catenin mRNA (encoded by CTNNB1) and protein. Levels of lincRNA-UFC1 correlated with those of ¦Â-catenin in HCC tissues.?In contrast, there was a negative correlation between levels of microRNA 34a and lincRNA-UFC1 in HCC tissues; microRNA 34a reduced the stability of lincRNA-UFC1. 1723 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA XIAP apoptosis up Homo sapiens rheumatoid arthritis synovial fibroblasts 22161761 9606 331 API3|BIRC4|IAP-3|ILP1|MIHA|XLP2|hIAP-3|hIAP3 HGNC:592|MIM:300079|Ensembl:ENSG00000101966|HPRD:02094|Vega:OTTHUMG00000022336 X Xq25 X-linked inhibitor of apoptosis protein-coding X-linked inhibitor of apoptosis Enforced expression of miR-34a* led to an increased rate of FasL- and TRAIL-mediated apoptosis in RASFs. Moreover, levels of miR-34a* were highly correlated with expression of XIAP, which was found to be up-regulated in RA synovial cells. Finally, we identified XIAP as a direct target of miR-34a*. 1724 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA XIAP apoptosis down Homo sapiens neuron 23948100 9606 331 API3|BIRC4|IAP-3|ILP1|MIHA|XLP2|hIAP-3|hIAP3 HGNC:592|MIM:300079|Ensembl:ENSG00000101966|HPRD:02094|Vega:OTTHUMG00000022336 X Xq25 X-linked inhibitor of apoptosis protein-coding X-linked inhibitor of apoptosis miR-34a directly inhibits Bcl2 and XIAP, both anti-apoptotic proteins. 1725 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA apoptosis Homo sapiens B-cell lymphoma cell 22522790 9606 Systemic microRNA-34a delivery induces apoptosis and abrogates growth of diffuse large B-cell lymphoma in vivo. 1726 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA apoptosis Homo sapiens glioma stem cells 22568628 9606 8842 RP41|AC133|CD133|MCDR2|STGD4|CORD12|PROML1|MSTP061 HGNC:9454|ENSG00000007062|HPRD:05079|MIM:604365|Vega:OTTHUMG00000160180 4 4p15.32 In particular, miR-34a has been found to inhibit proliferation and induce apoptosis in stem cells. 1727 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA apoptosis Homo sapiens bone marrow-mononuclear cells 22651868 9606 Inhibition of miR-34 by LNA-34a significantly reduced miR-34a expression and blocked hydrogen peroxide-induced cell death of BMC in vitro, whereas overexpression of miR-34a reduced the survival of BMCs in vitro. 1728 miR-34a-3p hsa-miR-34a-3p MIMAT0004557 miRNA SP4 apoptosis down Homo sapiens cervical 24249224 9606 6671 HF1B|SPR-1 HGNC:11209|MIM:600540|Ensembl:ENSG00000105866|HPRD:02764|Vega:OTTHUMG00000094801 7 7p15.3 Sp4 transcription factor protein-coding Sp4 transcription factor apoptosis during TGF-¦Â signaling, where SIRT1 and SP4 are suppressed by miR-34a-5p and miR-34a-3p, respectively 1729 miR-34a-5p hsa-miR-34a-5p MIMAT0000255 miRNA SIRT1 apoptosis down Homo sapiens cervical 24249224 9606 23411 SIR2L1 HGNC:14929|MIM:604479|Ensembl:ENSG00000096717|HPRD:08381|Vega:OTTHUMG00000018340 10 10q21.3 sirtuin 1 protein-coding sirtuin 1 apoptosis during TGF-¦Â signaling, where SIRT1 and SP4 are suppressed by miR-34a-5p and miR-34a-3p, respectively 1730 miR-34b hsa-miR-34b-5p,hsa-miR-34b-3p MIMAT0000685,MIMAT0004676 miRNA AKT1 apoptosis down Homo sapiens prostate 23147995 9606 207 AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA HGNC:391|MIM:164730|Ensembl:ENSG00000142208|HPRD:01261|Vega:OTTHUMG00000170795 14 14q32.32 v-akt murine thymoma viral oncogene homolog 1 protein-coding v-akt murine thymoma viral oncogene homolog 1 Functionally, miR-34b inhibited cell proliferation, colony formation, migration/invasion, and triggered G(0)/G(1) cell-cycle arrest and apoptosis by directly targeting the Akt and its downstream proliferative genes. 1731 miR-34b hsa-miR-34c-5p,hsa-miR-34c-3p MIMAT0000381,MIMAT0004580 miRNA BCL2 apoptosis Homo sapiens colon cancer cells 17656095 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 apoptosis regulator Bcl-2 Using gene-expression analyses, reporter gene assays, and chromatin-immunoprecipitation approaches, we present definitive evidence that the abundance of the three-member miRNA34 family is directly regulated by p53 in cell lines and tissues. Using array-based approaches and algorithm predictions, we define genes likely to be directly regulated by miRNA34, with cell-cycle regulatory genes being the most prominent class. In addition, we provide functional evidence, obtained via antisense oligonucleotide transfection and the use of mouse embryonic stem cells with loss of miRNA34a function, that the BCL2 protein is regulated directly by miRNA34. 1732 miR-34b hsa-miR-34b-5p,hsa-miR-34b-3p MIMAT0000685,MIMAT0004676 miRNA BCL2 apoptosis down Homo sapiens malignant pleural mesothelioma cells 23155254 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 The clonogenic survival assay revealed that miR-34b/c radiosensitized MPM cells. ¦ÃH2AX foci assay showed that DNA double-strand break repair was delayed in miR-34b/c transfectants. The proportion of sub-G(1) phase cells was increased in miR-34b/c transfectants after irradiation. miR-34b/c inhibited expression of cyclin-D1, cyclin-dependent kinase 4/6, B-cell lymphoma-2 (BCL-2) and increased cleaved poly (ADP-ribose) polymerase (cPARP) and cleaved caspase-3 after irradiation. 1733 miR-34b hsa-miR-34b-5p,hsa-miR-34b-3p MIMAT0000685,MIMAT0004676 miRNA CASP3 apoptosis up Homo sapiens malignant pleural mesothelioma cells 23155254 9606 836 CPP32|CPP32B|SCA-1 HGNC:1504|MIM:600636|Ensembl:ENSG00000164305|HPRD:02799|Vega:OTTHUMG00000133681 4 4q34 caspase 3, apoptosis-related cysteine peptidase protein-coding caspase 3, apoptosis-related cysteine peptidase The clonogenic survival assay revealed that miR-34b/c radiosensitized MPM cells. ¦ÃH2AX foci assay showed that DNA double-strand break repair was delayed in miR-34b/c transfectants. The proportion of sub-G(1) phase cells was increased in miR-34b/c transfectants after irradiation. miR-34b/c inhibited expression of cyclin-D1, cyclin-dependent kinase 4/6, B-cell lymphoma-2 (BCL-2) and increased cleaved poly (ADP-ribose) polymerase (cPARP) and cleaved caspase-3 after irradiation. 1734 miR-34b hsa-miR-34b-5p,hsa-miR-34b-3p MIMAT0000685,MIMAT0004676 miRNA CCND1 apoptosis down Homo sapiens malignant pleural mesothelioma cells 23155254 9606 595 BCL1|D11S287E|PRAD1|U21B31 HGNC:1582|MIM:168461|Ensembl:ENSG00000110092|HPRD:01346|Vega:OTTHUMG00000167877 11 11q13 cyclin D1 protein-coding cyclin D1 The clonogenic survival assay revealed that miR-34b/c radiosensitized MPM cells. ¦ÃH2AX foci assay showed that DNA double-strand break repair was delayed in miR-34b/c transfectants. The proportion of sub-G(1) phase cells was increased in miR-34b/c transfectants after irradiation. miR-34b/c inhibited expression of cyclin-D1, cyclin-dependent kinase 4/6, B-cell lymphoma-2 (BCL-2) and increased cleaved poly (ADP-ribose) polymerase (cPARP) and cleaved caspase-3 after irradiation. 1735 miR-34b hsa-miR-34b-5p,hsa-miR-34b-3p MIMAT0000685,MIMAT0004676 miRNA CDK4 apoptosis down Homo sapiens malignant pleural mesothelioma cells 23155254 9606 1019 CMM3|PSK-J3 HGNC:1773|MIM:123829|Ensembl:ENSG00000135446|HPRD:00447|Vega:OTTHUMG00000170382 12 12q14 cyclin-dependent kinase 4 protein-coding cyclin-dependent kinase 4 The clonogenic survival assay revealed that miR-34b/c radiosensitized MPM cells. ¦ÃH2AX foci assay showed that DNA double-strand break repair was delayed in miR-34b/c transfectants. The proportion of sub-G(1) phase cells was increased in miR-34b/c transfectants after irradiation. miR-34b/c inhibited expression of cyclin-D1, cyclin-dependent kinase 4/6, B-cell lymphoma-2 (BCL-2) and increased cleaved poly (ADP-ribose) polymerase (cPARP) and cleaved caspase-3 after irradiation. 1736 miR-34b hsa-miR-34b-5p,hsa-miR-34b-3p MIMAT0000685,MIMAT0004676 miRNA CDK6 apoptosis down Homo sapiens malignant pleural mesothelioma cells 23155254 9606 1021 PLSTIRE HGNC:1777|MIM:603368|Ensembl:ENSG00000105810|HPRD:04533|Vega:OTTHUMG00000131697 7 7q21-q22 cyclin-dependent kinase 6 protein-coding cyclin-dependent kinase 6 The clonogenic survival assay revealed that miR-34b/c radiosensitized MPM cells. ¦ÃH2AX foci assay showed that DNA double-strand break repair was delayed in miR-34b/c transfectants. The proportion of sub-G(1) phase cells was increased in miR-34b/c transfectants after irradiation. miR-34b/c inhibited expression of cyclin-D1, cyclin-dependent kinase 4/6, B-cell lymphoma-2 (BCL-2) and increased cleaved poly (ADP-ribose) polymerase (cPARP) and cleaved caspase-3 after irradiation. 1737 miR-34b hsa-miR-34b-5p,hsa-miR-34b-3p MIMAT0000685,MIMAT0004676 miRNA PARP1 apoptosis up Homo sapiens malignant pleural mesothelioma cells 23155254 9606 142 ADPRT|ADPRT 1|ADPRT1|ARTD1|PARP|PARP-1|PPOL|pADPRT-1 HGNC:270|MIM:173870|Ensembl:ENSG00000143799|HPRD:01435|Vega:OTTHUMG00000037556 1 1q41-q42 poly (ADP-ribose) polymerase 1 protein-coding poly (ADP-ribose) polymerase 1 The clonogenic survival assay revealed that miR-34b/c radiosensitized MPM cells. ¦ÃH2AX foci assay showed that DNA double-strand break repair was delayed in miR-34b/c transfectants. The proportion of sub-G(1) phase cells was increased in miR-34b/c transfectants after irradiation. miR-34b/c inhibited expression of cyclin-D1, cyclin-dependent kinase 4/6, B-cell lymphoma-2 (BCL-2) and increased cleaved poly (ADP-ribose) polymerase (cPARP) and cleaved caspase-3 after irradiation. 1738 miR-34b miRNA TP53 apoptosis Homo sapiens colon cancer cells 17656095 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 apoptosis regulator Bcl-2 Using gene-expression analyses, reporter gene assays, and chromatin-immunoprecipitation approaches, we present definitive evidence that the abundance of the three-member miRNA34 family is directly regulated by p53 in cell lines and tissues. 1739 miR-34b hsa-miR-34b-5p,hsa-miR-34b-3p MIMAT0000685,MIMAT0004676 miRNA apoptosis Homo sapiens malignant pleural mesothelioma cells 21673066 9606 The forced overexpression of miR-34b/c, but not p53, showed a significant antitumor effect with the induction of apoptosis in MPM cells. 1740 miR-34b hsa-miR-34b-5p,hsa-miR-34b-3p MIMAT0000685,MIMAT0004676 miRNA apoptosis Homo sapiens 24140040 9606 Bioinformatics analysis showed that five microRNAs (hsa-mir-34b*, hsa-mir-34b, hsa-mir-34c-5p, hsa-mir-449a, and hsa-mir-449b*) were involved in apoptosis, cell proliferation, and differentiation. 1741 miR-34b-5p hsa-miR-34b-5p MIMAT0000685 miRNA apoptosis Homo sapiens 24140040 9606 Bioinformatics analysis showed that five microRNAs (hsa-mir-34b*, hsa-mir-34b, hsa-mir-34c-5p, hsa-mir-449a, and hsa-mir-449b*) were involved in apoptosis, cell proliferation, and differentiation. 1742 miR-34c hsa-miR-34c-5p,hsa-miR-34c-3p MIMAT0000686,MIMAT0004677 miRNA BAX apoptosis up Homo sapiens VSMCs cells|A12 cells 25683915 9606 581 BCL2L4 HGNC:959|MIM:600040|Ensembl:ENSG00000087088|HPRD:02498|Vega:OTTHUMG00000160476 19 19q13.3-q13.4 BCL2-associated X protein protein-coding BCL2-associated X protein BCL2-associated X protein Transient transfection of miR-34c to either VSMCs or A10 cells inhibited cell survival by inducing apoptosis, which was accompanied by an increase in expression of p21, p27, and Bax. 1743 miR-34c hsa-miR-34c-5p,hsa-miR-34c-3p MIMAT0000381,MIMAT0004580 miRNA BCL2 apoptosis Homo sapiens colon cancer cells 17656095 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 apoptosis regulator Bcl-2 Using gene-expression analyses, reporter gene assays, and chromatin-immunoprecipitation approaches, we present definitive evidence that the abundance of the three-member miRNA34 family is directly regulated by p53 in cell lines and tissues. Using array-based approaches and algorithm predictions, we define genes likely to be directly regulated by miRNA34, with cell-cycle regulatory genes being the most prominent class. In addition, we provide functional evidence, obtained via antisense oligonucleotide transfection and the use of mouse embryonic stem cells with loss of miRNA34a function, that the BCL2 protein is regulated directly by miRNA34. 1744 miR-34c hsa-miR-34c-5p,hsa-miR-34c-3p MIMAT0000686,MIMAT0004677 miRNA BCL2 apoptosis up Homo sapiens prostate cancer cells 21351256 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 apoptosis regulator Bcl-2 MiR-34c was found to negatively regulate the oncogenes E2F3 and BCL-2, which stimulates proliferation and suppress apoptosis in PCa cells, 1745 miR-34c hsa-miR-34c-5p,hsa-miR-34c-3p MIMAT0000686,MIMAT0004677 miRNA BCL2 apoptosis down Homo sapiens malignant pleural mesothelioma cells 23155254 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 The clonogenic survival assay revealed that miR-34b/c radiosensitized MPM cells. ¦ÃH2AX foci assay showed that DNA double-strand break repair was delayed in miR-34b/c transfectants. The proportion of sub-G(1) phase cells was increased in miR-34b/c transfectants after irradiation. miR-34b/c inhibited expression of cyclin-D1, cyclin-dependent kinase 4/6, B-cell lymphoma-2 (BCL-2) and increased cleaved poly (ADP-ribose) polymerase (cPARP) and cleaved caspase-3 after irradiation. 1746 miR-34c hsa-miR-34c-5p,hsa-miR-34c-3p MIMAT0000686,MIMAT0004677 miRNA CASP3 apoptosis up Homo sapiens malignant pleural mesothelioma cells 23155254 9606 836 CPP32|CPP32B|SCA-1 HGNC:1504|MIM:600636|Ensembl:ENSG00000164305|HPRD:02799|Vega:OTTHUMG00000133681 4 4q34 caspase 3, apoptosis-related cysteine peptidase protein-coding caspase 3, apoptosis-related cysteine peptidase The clonogenic survival assay revealed that miR-34b/c radiosensitized MPM cells. ¦ÃH2AX foci assay showed that DNA double-strand break repair was delayed in miR-34b/c transfectants. The proportion of sub-G(1) phase cells was increased in miR-34b/c transfectants after irradiation. miR-34b/c inhibited expression of cyclin-D1, cyclin-dependent kinase 4/6, B-cell lymphoma-2 (BCL-2) and increased cleaved poly (ADP-ribose) polymerase (cPARP) and cleaved caspase-3 after irradiation. 1747 miR-34c hsa-miR-34c-5p,hsa-miR-34c-3p MIMAT0000686,MIMAT0004677 miRNA CCND1 apoptosis down Homo sapiens malignant pleural mesothelioma cells 23155254 9606 595 BCL1|D11S287E|PRAD1|U21B31 HGNC:1582|MIM:168461|Ensembl:ENSG00000110092|HPRD:01346|Vega:OTTHUMG00000167877 11 11q13 cyclin D1 protein-coding cyclin D1 The clonogenic survival assay revealed that miR-34b/c radiosensitized MPM cells. ¦ÃH2AX foci assay showed that DNA double-strand break repair was delayed in miR-34b/c transfectants. The proportion of sub-G(1) phase cells was increased in miR-34b/c transfectants after irradiation. miR-34b/c inhibited expression of cyclin-D1, cyclin-dependent kinase 4/6, B-cell lymphoma-2 (BCL-2) and increased cleaved poly (ADP-ribose) polymerase (cPARP) and cleaved caspase-3 after irradiation. 1748 miR-34c hsa-miR-34c-5p,hsa-miR-34c-3p MIMAT0000686,MIMAT0004677 miRNA CDK4 apoptosis down Homo sapiens malignant pleural mesothelioma cells 23155254 9606 1019 CMM3|PSK-J3 HGNC:1773|MIM:123829|Ensembl:ENSG00000135446|HPRD:00447|Vega:OTTHUMG00000170382 12 12q14 cyclin-dependent kinase 4 protein-coding cyclin-dependent kinase 4 The clonogenic survival assay revealed that miR-34b/c radiosensitized MPM cells. ¦ÃH2AX foci assay showed that DNA double-strand break repair was delayed in miR-34b/c transfectants. The proportion of sub-G(1) phase cells was increased in miR-34b/c transfectants after irradiation. miR-34b/c inhibited expression of cyclin-D1, cyclin-dependent kinase 4/6, B-cell lymphoma-2 (BCL-2) and increased cleaved poly (ADP-ribose) polymerase (cPARP) and cleaved caspase-3 after irradiation. 1749 miR-34c hsa-miR-34c-5p,hsa-miR-34c-3p MIMAT0000686,MIMAT0004677 miRNA CDK6 apoptosis down Homo sapiens malignant pleural mesothelioma cells 23155254 9606 1021 PLSTIRE HGNC:1777|MIM:603368|Ensembl:ENSG00000105810|HPRD:04533|Vega:OTTHUMG00000131697 7 7q21-q22 cyclin-dependent kinase 6 protein-coding cyclin-dependent kinase 6 The clonogenic survival assay revealed that miR-34b/c radiosensitized MPM cells. ¦ÃH2AX foci assay showed that DNA double-strand break repair was delayed in miR-34b/c transfectants. The proportion of sub-G(1) phase cells was increased in miR-34b/c transfectants after irradiation. miR-34b/c inhibited expression of cyclin-D1, cyclin-dependent kinase 4/6, B-cell lymphoma-2 (BCL-2) and increased cleaved poly (ADP-ribose) polymerase (cPARP) and cleaved caspase-3 after irradiation. 1750 miR-34c hsa-miR-34c-5p,hsa-miR-34c-3p MIMAT0000686,MIMAT0004677 miRNA CDKN1A apoptosis up Homo sapiens VSMCs cells|A10 cells 25683915 9606 1026 CAP20|CDKN1|CIP1|MDA-6|P21|SDI1|WAF1|p21CIP1 HGNC:1784|MIM:116899|Ensembl:ENSG00000124762|HPRD:00298|Vega:OTTHUMG00000014603 6 6p21.2 cyclin-dependent kinase inhibitor 1A (p21, Cip1) protein-coding cyclin-dependent kinase inhibitor 1A (p21, Cip1) cyclin-dependent kinase inhibitor 1A (p21, Cip1) Transient transfection of miR-34c to either VSMCs or A10 cells inhibited cell survival by inducing apoptosis, which was accompanied by an increase in expression of p21, p27, and Bax. 1751 miR-34c hsa-miR-34c-5p,hsa-miR-34c-3p MIMAT0000686,MIMAT0004677 miRNA CDKN1B apoptosis up Homo sapiens VSMCs cells|A11 cells 25683915 9606 1027 CDKN4|KIP1|MEN1B|MEN4|P27KIP1 HGNC:1785|MIM:600778|Ensembl:ENSG00000111276|HPRD:02867|Vega:OTTHUMG00000149914 12 12p13.1-p12 cyclin-dependent kinase inhibitor 1B (p27, Kip1) protein-coding cyclin-dependent kinase inhibitor 1B (p27, Kip1) cyclin-dependent kinase inhibitor 1B (p27, Kip1) Transient transfection of miR-34c to either VSMCs or A10 cells inhibited cell survival by inducing apoptosis, which was accompanied by an increase in expression of p21, p27, and Bax. 1752 miR-34c hsa-miR-34c-5p,hsa-miR-34c-3p MIMAT0000686,MIMAT0004677 miRNA E2F3 apoptosis up Homo sapiens prostate cancer cells 21351256 9606 1871 E2F-3 HGNC:3115|MIM:600427|Ensembl:ENSG00000112242|HPRD:02693|Vega:OTTHUMG00000016389 6 6p22 E2F transcription factor 3 protein-coding E2F transcription factor 3 apoptosis regulator Bcl-2 MiR-34c was found to negatively regulate the oncogenes E2F3 and BCL-2, which stimulates proliferation and suppress apoptosis in PCa cells, 1753 miR-34c hsa-miR-34c-5p,hsa-miR-34c-3p MIMAT0000686,MIMAT0004677 miRNA PARP1 apoptosis up Homo sapiens malignant pleural mesothelioma cells 23155254 9606 142 ADPRT|ADPRT 1|ADPRT1|ARTD1|PARP|PARP-1|PPOL|pADPRT-1 HGNC:270|MIM:173870|Ensembl:ENSG00000143799|HPRD:01435|Vega:OTTHUMG00000037556 1 1q41-q42 poly (ADP-ribose) polymerase 1 protein-coding poly (ADP-ribose) polymerase 1 The clonogenic survival assay revealed that miR-34b/c radiosensitized MPM cells. ¦ÃH2AX foci assay showed that DNA double-strand break repair was delayed in miR-34b/c transfectants. The proportion of sub-G(1) phase cells was increased in miR-34b/c transfectants after irradiation. miR-34b/c inhibited expression of cyclin-D1, cyclin-dependent kinase 4/6, B-cell lymphoma-2 (BCL-2) and increased cleaved poly (ADP-ribose) polymerase (cPARP) and cleaved caspase-3 after irradiation. 1754 miR-34c hsa-miR-34c-5p,hsa-miR-34c-3p MIMAT0000686,MIMAT0004677 miRNA PDGFRA apoptosis down Homo sapiens lung tumor cells 23805317 9606 5156 CD140A|PDGFR-2|PDGFR2|RHEPDGFRA HGNC:8803|MIM:173490|Ensembl:ENSG00000134853|HPRD:01429|Vega:OTTHUMG00000128699 4 4q12 platelet-derived growth factor receptor, alpha polypeptide protein-coding platelet-derived growth factor receptor, alpha polypeptide MiR-34a/c-Dependent PDGFR-¦Á/¦Â Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer. miR-34a/c overexpression or downregulation of PDGFR-¦Á/¦Â by siRNAs, strongly augmented the response to TNF-related apoptosis inducing ligand (TRAIL) while reducing migratory and invasive capacity of NSCLC cells.we found that miR-34a and miR-34c target platelet-derived growth factor receptor alpha and beta (PDGFR-¦Á and PDGFR-¦Â), cell surface tyrosine kinase receptors that induce proliferation, migration and invasion in cancer.Moreover, we identified an inverse correlation between PDGFR-¦Á/¦Â and miR-34a/c expression in lung tumor samples. 1755 miR-34c hsa-miR-34c-5p,hsa-miR-34c-3p MIMAT0000686,MIMAT0004677 miRNA PDGFRB apoptosis down Homo sapiens 23805317 9606 5159 CD140B|IBGC4|IMF1|JTK12|PDGFR|PDGFR-1|PDGFR1 HGNC:8804|MIM:173410|Ensembl:ENSG00000113721|HPRD:01423|Vega:OTTHUMG00000130053 5 5q33.1 platelet-derived growth factor receptor, beta polypeptide protein-coding platelet-derived growth factor receptor, beta polypeptide MiR-34a/c-Dependent PDGFR-¦Á/¦Â Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer. miR-34a/c overexpression or downregulation of PDGFR-¦Á/¦Â by siRNAs, strongly augmented the response to TNF-related apoptosis inducing ligand (TRAIL) while reducing migratory and invasive capacity of NSCLC cells.we found that miR-34a and miR-34c target platelet-derived growth factor receptor alpha and beta (PDGFR-¦Á and PDGFR-¦Â), cell surface tyrosine kinase receptors that induce proliferation, migration and invasion in cancer.Moreover, we identified an inverse correlation between PDGFR-¦Á/¦Â and miR-34a/c expression in lung tumor samples. 1756 miR-34c miRNA TP53 apoptosis Homo sapiens colon cancer cells 17656095 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 apoptosis regulator Bcl-2 Using gene-expression analyses, reporter gene assays, and chromatin-immunoprecipitation approaches, we present definitive evidence that the abundance of the three-member miRNA34 family is directly regulated by p53 in cell lines and tissues. 1757 miR-34c hsa-miR-34c-5p,hsa-miR-34c-3p MIMAT0000686,MIMAT0004677 miRNA apoptosis Homo sapiens malignant pleural mesothelioma cells 21673066 9606 The forced overexpression of miR-34b/c, but not p53, showed a significant antitumor effect with the induction of apoptosis in MPM cells. 1758 miR-34c-3p hsa-miR-34c-3p MIMAT0004677 miRNA apoptosis Homo sapiens human melanoma cell line cells 22192732 9606 For instance, endothelin-1 promotes cell proliferation, cell invasion, and apoptotic inhibition of osteosarcomas demonstrated that microRNA (miR) 34c-3p inhibited cell proliferation and migration and induced apoptosis of the cervical carcinoma cell line SiHa. 1759 miR-34c-3p hsa-miR-34c-3p MIMAT0004677 miRNA apoptosis Homo sapiens U87 cell 24179539 9606 Transfection with miR-34c-3p or miR-34c-5p in U251 cells and with miR-34c-3p in U87 cells produced S-phase arrest with G0/G1 reduction and induced cell apoptosis, but no significant changes were observed with miR-34c-5p transfection in U87 cells, normal or negative control groups 1760 miR-34c-5p hsa-miR-34c-5p MIMAT0000686 miRNA BMF apoptosis down Homo sapiens a derivative of the non-small cell lung carcinoma A549 cell line 22370637 9606 90427 - HGNC:24132|MIM:606266|Ensembl:ENSG00000104081|HPRD:05881|Vega:OTTHUMG00000129875 15 15q14 Bcl2 modifying factor protein-coding Bcl2 modifying factor We demonstrate that Bmf (Bcl-2-modifying factor) is a target of miR-34c-5p, and that its silencing, together with that of c-myc, a known target of miR-34c-5p, contributes to resistance to apoptosis induced by paclitaxel through p53 downregulation. 1761 miR-34c-5p hsa-miR-34c-3p MIMAT0004677 miRNA apoptosis Homo sapiens 24140040 9606 Bioinformatics analysis showed that five microRNAs (hsa-mir-34b*, hsa-mir-34b, hsa-mir-34c-5p, hsa-mir-449a, and hsa-mir-449b*) were involved in apoptosis, cell proliferation, and differentiation. 1762 miR-3607 hsa-miR-3607-5p£¬hsa-miR-3607-3p MIMAT0017984,MIMAT0017985 miRNA LYN apoptosis down Homo sapiens prostate cancer cell 24817628 9606 4067 JTK8|p53Lyn|p56Lyn HGNC:6735|MIM:165120|Ensembl:ENSG00000254087|HPRD:01301|Vega:OTTHUMG00000044345 8 8q13 LYN proto-oncogene, Src family tyrosine kinase protein-coding LYN proto-oncogene, Src family tyrosine kinase We examined the functional significance of miR-3607 in prostate cancer cell lines and found that miR-3607 overexpression led to significantly decreased proliferation, apoptosis induction, and decreased invasiveness. Furthermore, our results suggest that miR-3607 directly represses oncogenic SRC family kinases LYN and SRC in prostate cancer. 1763 miR-3607 hsa-miR-3607-5p£¬hsa-miR-3607-3p MIMAT0017984,MIMAT0017985 miRNA SRC apoptosis down Homo sapiens prostate cancer cell 24817628 9606 6714 ASV|SRC1|c-SRC|p60-Src HGNC:11283|MIM:190090|Ensembl:ENSG00000197122|HPRD:01819|Vega:OTTHUMG00000032417 20 20q12-q13 SRC proto-oncogene, non-receptor tyrosine kinase protein-coding SRC proto-oncogene, non-receptor tyrosine kinase We examined the functional significance of miR-3607 in prostate cancer cell lines and found that miR-3607 overexpression led to significantly decreased proliferation, apoptosis induction, and decreased invasiveness. Furthermore, our results suggest that miR-3607 directly represses oncogenic SRC family kinases LYN and SRC in prostate cancer. 1764 miR-361 hsa-miR-361-5p,hsa-miR-361-3p MIMAT0000703,MIMAT0004682 miRNA ABCB1 apoptosis down Homo sapiens 25057983 9606 5243 ABC20|CD243|CLCS|GP170|MDR1|P-GP|PGY1 HGNC:40|MIM:171050|Ensembl:ENSG00000085563|HPRD:01370|Vega:OTTHUMG00000023393 7 7q21.12 ATP-binding cassette, sub-family B (MDR/TAP), member 1 protein-coding ATP-binding cassette, sub-family B (MDR/TAP), member 1 MiR-361 is able to regulate mitochondrial fission and apoptosis by regulating miR-484 levels. In exploring the underlying molecular mechanism by which miR-361 is regulated, we identified MDRL and demonstrated that it could directly bind to miR-361 and downregulate its expression levels, which promotes the processing of pri-miR-484. 1765 miR-361 hsa-miR-361-5p,hsa-miR-361-3p MIMAT0000703,MIMAT0004682 miRNA PHB apoptosis down Homo sapiens Cardiovascular cell 25501599 9606 5245 HEL-215|HEL-S-54e|PHB1 HGNC:8912|MIM:176705|Ensembl:ENSG00000167085|HPRD:01454|Vega:OTTHUMG00000134271 17 17q21 prohibitin protein-coding prohibitin Here we report that miR-361 and prohibitin 1 (PHB1) constitute an axis that regulates mitochondrial fission and apoptosis. The results show that PHB1 attenuates mitochondrial fission and apoptosis in response to hydrogen peroxide treatment in cardiomyocytes. Cardiac-specific PHB1 transgenic mice show reduced mitochondrial fission and myocardial infarction sizes after myocardial infarction surgery. MiR-361 is responsible for the dysfunction of PHB1 and suppresses the translation of PHB1. 1766 miR-362 hsa-miR-362-5p,hsa-miR-362-3p MIMAT0000705,MIMAT0004683 miRNA NFKB1 apoptosis up Homo sapiens gastric cancer cell 24495516 9606 4790 EBP-1|KBF1|NF-kB1|NF-kappa-B|NF-kappaB|NFKB-p105|NFKB-p50|NFkappaB|p105|p50 HGNC:7794|MIM:164011|Ensembl:ENSG00000109320|HPRD:01238|Vega:OTTHUMG00000161080 4 4q24 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 protein-coding nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 MicroRNA-362 induces cell proliferation and apoptosis resistance in gastric cancer by activation of NF-¦ÊB signaling. 1767 miR-363 hsa-miR-363-5p,hsa-miR-363-3p MIMAT0003385,MIMAT0000707 miRNA MCL1 apoptosis down Homo sapiens breast cancer cell 25416050 9606 4170 BCL2L3|EAT|MCL1-ES|MCL1L|MCL1S|Mcl-1|TM|bcl2-L-3|mcl1/EAT HGNC:6943|MIM:159552|Ensembl:ENSG00000143384|HPRD:08870|Vega:OTTHUMG00000034867 1 1q21 myeloid cell leukemia 1 protein-coding myeloid cell leukemia 1 MiR-363 sensitizes cisplatin-induced apoptosis targeting in Mcl-1 in breast cancer. 1768 miR-365 hsa-miR-365a-5p,hsa-miR-365a-3p MIMAT0000710,MIMAT0009199 miRNA BCL2 apoptosis down Homo sapiens colon cancer cell 22072615 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Moreover, we showed that the miR-125a mimic downregulated the antiapoptotic Bcl2 protein and upregulated caspase 3, suggesting that these two proteins represent molecular targets for miR-125a. 1769 miR-365 hsa-miR-365a-5p,hsa-miR-365a-3p MIMAT0000710,MIMAT0009199 miRNA CASP3 apoptosis down Homo sapiens colon cancer cell 22072615 9606 836 CPP32|CPP32B|SCA-1 HGNC:1504|MIM:600636|Ensembl:ENSG00000164305|HPRD:02799|Vega:OTTHUMG00000133681 4 4q34 caspase 3, apoptosis-related cysteine peptidase protein-coding caspase 3, apoptosis-related cysteine peptidase Moreover, we showed that the miR-125a mimic downregulated the antiapoptotic Bcl2 protein and upregulated caspase 3, suggesting that these two proteins represent molecular targets for miR-125a. 1770 miR-365b hsa-miR-365b-5p,hsa-miR-365b-3p MIMAT0022833,MIMAT0022834 miRNA BCL2 apoptosis down Homo sapiens breast cancer cells 22328513 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 apoptosis regulator Bcl-2 Ectopic expression of miR-195, miR-24-2 and miR-365-2 individually led to a significant reduction of the levels of BCL2 protein. 1771 miR-365b-3p hsa-miR-365b-3p MIMAT0022834 miRNA CCND1 apoptosis down Homo sapiens human RB tissues 23660406 9606 595 BCL1|D11S287E|PRAD1|U21B31 HGNC:1582|MIM:168461|Ensembl:ENSG00000110092|HPRD:01346|Vega:OTTHUMG00000167877 11 11q13 cyclin D1 protein-coding cyclin D1 Overexpression of miR-365b-3p upregulates p21 and p27 but downregulates cdc2 and Cyclin D1 protein levels. 1772 miR-365b-3p hsa-miR-365b-3p MIMAT0022834 miRNA CDK1 apoptosis down Homo sapiens human RB tissues 23660406 9606 983 CDC2|CDC28A|P34CDC2 HGNC:1722|MIM:116940|Ensembl:ENSG00000170312|HPRD:00302|Vega:OTTHUMG00000018290 10 10q21.1 cyclin-dependent kinase 1 protein-coding cyclin-dependent kinase 1 Overexpression of miR-365b-3p upregulates p21 and p27 but downregulates cdc2 and Cyclin D1 protein levels. 1773 miR-365b-3p hsa-miR-365b-3p MIMAT0022834 miRNA CDKN1A apoptosis up Homo sapiens human RB tissues 23660406 9606 1026 CAP20|CDKN1|CIP1|MDA-6|P21|SDI1|WAF1|p21CIP1 HGNC:1784|MIM:116899|Ensembl:ENSG00000124762|HPRD:00298|Vega:OTTHUMG00000014603 6 6p21.2 cyclin-dependent kinase inhibitor 1A (p21, Cip1) protein-coding cyclin-dependent kinase inhibitor 1A (p21, Cip1) Overexpression of miR-365b-3p upregulates p21 and p27 but downregulates cdc2 and Cyclin D1 protein levels. 1774 miR-365b-3p hsa-miR-365b-3p MIMAT0022834 miRNA CDKN1B apoptosis up Homo sapiens human RB tissues 23660406 9606 1027 CDKN4|KIP1|MEN1B|MEN4|P27KIP1 HGNC:1785|MIM:600778|Ensembl:ENSG00000111276|HPRD:02867|Vega:OTTHUMG00000149914 12 12p13.1-p12 cyclin-dependent kinase inhibitor 1B (p27, Kip1) protein-coding cyclin-dependent kinase inhibitor 1B (p27, Kip1) Overexpression of miR-365b-3p upregulates p21 and p27 but downregulates cdc2 and Cyclin D1 protein levels. 1775 miR-370 hsa-miR-370-5p,hsa-miR-370-3p MIMAT0026483,MIMAT0000722 miRNA GADD45B apoptosis down Homo sapiens EV71-infected cell 25469565 9606 4616 GADD45BETA|MYD118 HGNC:4096|MIM:604948|Ensembl:ENSG00000099860|HPRD:05382|Vega:OTTHUMG00000180434 19 19p13.3 growth arrest and DNA-damage-inducible, beta protein-coding growth arrest and DNA-damage-inducible, beta Luciferase reporter assays and Western blots demonstrated the negative regulation between miR-146a and SOS1 and between miR-370 and GADD45¦Â. Silencing of miR-146a restored SOS1 expression and partially attenuated EV71 infection-induced apoptosis. Conversely, ectopic expression of miR-370 decreased virus infection-induced GADD45¦Â expression and also diminished apoptosis. 1776 miR-372 hsa-miR-372-5p,hsa-miR-372-3p MIMAT0026484,MIMAT0000724 miRNA PHLPP2 apoptosis down Homo sapiens glioma 25160587 9606 23035 PHLPPL HGNC:29149|MIM:611066|Ensembl:ENSG00000040199|HPRD:11118|Vega:OTTHUMG00000176867 16 16q22.2 PH domain and leucine rich repeat protein phosphatase 2 protein-coding PH domain and leucine rich repeat protein phosphatase 2 MicroRNAs are known to be involved in carcinogenesis and tumor progression in glioma. Recently, microRNA-372 (miR-372) has been proved to play a substantial role in several human cancers, but its functions in glioma remain unclear. In this study, we confirmed that miR-372 was commonly upregulated in glioma cell lines and tissues. Downregulation of miR-372 markedly inhibited cell proliferation and invasion and induced G1/S arrest and apoptosis. Consistently, the xenograft mouse model also unveiled the suppressive effects of miR-372 knockdown on tumor growth. Further studies revealed that miR-372 modulated the expression of PHLPP2 by directly targeting its 3'-untranslated region (3'-UTR) and that miR-372 expression was inversely correlated with PHLPP2 expression in glioma samples. Silencing of PHLPP2 could rescue the inhibitory effect of miR-372 inhibitor. Moreover, miR-372 knockdown suppressed the phosphorylation levels of the major components of PI3K/Akt pathway including Akt, mTOR, and P70S6K. Taken together, our results suggest that miR-372 functions as an oncogenic miRNA through targeting PHLPP2 in glioma. 1777 miR-372 hsa-miR-372-3p,hsa-miR-372-5p MIMAT0000724,MIMAT0026484 miRNA TNFAIP1 apoptosis down Homo sapiens human gastric carcinoma cell 23242208 9606 7126 B12|B61|BTBD34|EDP1|hBACURD2 HGNC:11894|MIM:191161|Ensembl:ENSG00000109079|HPRD:01856|Vega:OTTHUMG00000132501 17 17q22-q23 tumor necrosis factor, alpha-induced protein 1 (endothelial) protein-coding tumor necrosis factor, alpha-induced protein 1 (endothelial) In the present study, we found that microRNA-372 (miR-372) directly targets tumor necrosis factor, ¦Á-induced protein 1 (TNFAIP1), and is involved in the regulation of the NF¦ÊB signaling pathway. 1778 miR-372 hsa-miR-372-3p,hsa-miR-372-5p MIMAT0000724,MIMAT0026484 miRNA apoptosis Homo sapiens hepatocellular carcinoma cell 23291979 9606 MicroRNA-372 (miR-372) has been demonstrated to play a crucial role in cellular proliferation and apoptosis of cancer cells. 1779 miR-373 hsa-miR-373-5p,hsa-miR-373-3p MIMAT0000725,MIMAT0000726 miRNA LATS2 apoptosis down Homo sapiens esophageal squamous cell 19501585 9606 26524 KPM HGNC:6515|MIM:604861|Ensembl:ENSG00000150457|HPRD:07277|Vega:OTTHUMG00000016531 13 13q11-q12 large tumor suppressor kinase 2 protein-coding large tumor suppressor kinase 2 LATS2 is a member of the LATS tumor suppressor family. It has been implicated in regulation of the cell cycle and apoptosis. Our findings reveal that miR-373 would be a potential oncogene and it participates in the carcinogenesis of human esophageal cancer by suppressing LATS2 expression. 1780 miR-373 hsa-miR-373-5p,hsa-miR-373-3p MIMAT0000725,MIMAT0000726 miRNA PIK3CA apoptosis Homo sapiens lung cancer cell 25591738 9606 5290 CLOVE|CWS5|MCAP|MCM|MCMTC|PI3K|p110-alpha HGNC:8975|MIM:171834|HPRD:01382 3 3q26.3 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha protein-coding phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha Re-expression of both miRs augmented cisplatin-induced apoptosis and inhibited cell migration; miR-512 also reduced cell proliferation. TEAD4 mRNA was confirmed as a direct target of miR-512; likewise, miR-373 was found to target RelA and PIK3CA mRNA directly. Our results imply that miR-512 and miR-373 exert cell-autonomous and non-autonomous tumor-suppressive effects in lung cancer cells, where their re-expression may benefit epigenetic cancer therapy.Cell Death and Differentiation advance online 1781 miR-373 hsa-miR-373-5p,hsa-miR-373-3p MIMAT0000725,MIMAT0000726 miRNA RELA apoptosis Homo sapiens lung cancer cell 25591738 9606 5970 NFKB3|p65 HGNC:9955|MIM:164014|Ensembl:ENSG00000173039|HPRD:01241|Vega:OTTHUMG00000166566 11 11q13 v-rel avian reticuloendotheliosis viral oncogene homolog A protein-coding v-rel avian reticuloendotheliosis viral oncogene homolog A Re-expression of both miRs augmented cisplatin-induced apoptosis and inhibited cell migration; miR-512 also reduced cell proliferation. TEAD4 mRNA was confirmed as a direct target of miR-512; likewise, miR-373 was found to target RelA and PIK3CA mRNA directly. Our results imply that miR-512 and miR-373 exert cell-autonomous and non-autonomous tumor-suppressive effects in lung cancer cells, where their re-expression may benefit epigenetic cancer therapy.Cell Death and Differentiation advance online 1782 miR-374a hsa-miR-374a-5p,hsa-miR-374a-3p MIMAT0000727,MIMAT0004688 miRNA AXL apoptosis Homo sapiens NSCLC cell 24832599 9606 558 JTK11|UFO HGNC:905|MIM:109135|Ensembl:ENSG00000167601|HPRD:00171|Vega:OTTHUMG00000182727 19 19q13.1 AXL receptor tyrosine kinase protein-coding AXL receptor tyrosine kinase In this study, we validate and report that miR-374a and miR-548b modulated by Axl have essential roles in cell cycle arrest, gefitinib-induced apoptosis, epithelial-to-mesenchymal transition, migration and tumorigenesis of gefitinib-resistant lung cancer cells in vitro and in vivo by targeting Wnt5a and CCNB1 genes, respectively. 1783 miR-374a hsa-miR-374a-5p,hsa-miR-374a-3p MIMAT0000727,MIMAT0004688 miRNA WNT5A apoptosis Homo sapiens NSCLC cell 24832599 9606 7474 hWNT5A HGNC:12784|MIM:164975|Ensembl:ENSG00000114251|HPRD:01293|Vega:OTTHUMG00000158361 3 3p21-p14 wingless-type MMTV integration site family, member 5A protein-coding wingless-type MMTV integration site family, member 5A In this study, we validate and report that miR-374a and miR-548b modulated by Axl have essential roles in cell cycle arrest, gefitinib-induced apoptosis, epithelial-to-mesenchymal transition, migration and tumorigenesis of gefitinib-resistant lung cancer cells in vitro and in vivo by targeting Wnt5a and CCNB1 genes, respectively. 1784 miR-375 hsa-miR-375 MIMAT0000728 miRNA AKT1 apoptosis down Homo sapiens gastric carcinoma cells 20215506 9606 207 AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA HGNC:391|MIM:164730|Ensembl:ENSG00000142208|HPRD:01261|Vega:OTTHUMG00000170795 14 14q32.32 v-akt murine thymoma viral oncogene homolog 1 protein-coding v-akt murine thymoma viral oncogene homolog 1 14-3-3 delta|14-3-3 prote We found that miRNA-375 (miR-375) was the most downregulated and that its ectopic expression in gastric carcinoma cells markedly reduced cell viability via the caspase-mediated apoptosis pathway. Interestingly, we found that expression of miR-375 inhibited expression of PDK1, which is a direct target of miR-375, followed by suppression of Akt phosphorylation. Further analysis by gene expression microarray revealed that 14-3-3zeta, a potent antiapoptotic gene, was significantly downregulated at both the mRNA and protein levels in cells transfected with miR-375. 1785 miR-375 hsa-miR-375 MIMAT0000728 miRNA AKT1 apoptosis Homo sapiens pancreatic carcinoma cell 24481267 9606 207 AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA HGNC:391|MIM:164730|Ensembl:ENSG00000142208|HPRD:01261|Vega:OTTHUMG00000170795 14 14q32.32 v-akt murine thymoma viral oncogene homolog 1 protein-coding v-akt murine thymoma viral oncogene homolog 1 Overexpression of miR-153 significantly inhibited the proliferation and migration, and promoted apoptosis of cultured lung cancer cells in vitro, and suppressed the growth of xenograft tumors in vivo. Interestingly, lung cancer cells with lower endogenous miR-153 expression are more sensitive to ectopic overexpressed miR-153. The IC50 of miR-153 on lung cancer cells is positive correlated with the endogenous miR-153 level, while negative correlated with AKT level. Knockdown of AKT expression suppressed lung cancer cell proliferation. In summary, miR-153 exerted anti-tumor activity in lung cancer by targeting on AKT. The sensitivity of lung cancer cells to miR-153 is determined by its endogenous miR-153 level. 1786 miR-375 hsa-miR-375 MIMAT0000728 miRNA AKT1 apoptosis down Homo sapiens squamous cell 25184138 9606 207 AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA HGNC:391|MIM:164730|Ensembl:ENSG00000142208|HPRD:01261|Vega:OTTHUMG00000170795 14 14q32.32 v-akt murine thymoma viral oncogene homolog 1 protein-coding v-akt murine thymoma viral oncogene homolog 1 The tumor-suppressive effect of miR-375 was determined by in vitro assays; through gain-of-function studies we demonstrated that miR-375 can inhibit LSCC cell (SNU-48 and SNU-899) proliferation, motility, and invasion, and promote their apoptosis. Ectopic transfection of miR-375 led to a significant reduction in IGF1R and its downstream signaling molecule AKT at both the mRNA and protein levels in LSCC cells. Our results suggested that downregulation of miR-375 is one of the molecular mechanisms for the development and progression of LSCC by directly targeting IGF1R and affecting its downstream AKT signaling pathways. Furthermore, miR-375 and IGF1R may serve as a novel therapeutic target for LSCC. 1787 miR-375 hsa-miR-375 MIMAT0000728 miRNA BCL2 apoptosis up Homo sapiens breast cancer cell 25613180 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 This study demonstrated that biochanin A promoted ER¦Á-positive cell proliferation through miR-375 activation and this mechanism is possibly involving in a miR-375 and ER¦Á feedback loop. 1788 miR-375 hsa-miR-375 MIMAT0000728 miRNA BCL2L1 apoptosis Homo sapiens colorectal cell 24892549 9606 598 BCL-XL/S|BCL2L|BCLX|BCLXL|BCLXS|Bcl-X|PPP1R52|bcl-xL|bcl-xS HGNC:992|MIM:600039|Ensembl:ENSG00000171552|HPRD:02497|Vega:OTTHUMG00000032192 20 20q11.21 BCL2-like 1 protein-coding BCL2-like 1 After treatment with biochanin A, ER¦Á, miR-375, and Bcl-2 expression was significantly upregulated. Additionally, in the in vivo studies, uterine weight in ovariectomized mice treated with biochanin A increased significantly. CONCLUSION: This study demonstrated that biochanin A promoted ER¦Á-positive cell proliferation through miR-375 activation and this mechanism is possibly involving in a miR-375 and ER¦Á feedback loop. 1789 miR-375 hsa-miR-375 MIMAT0000728 miRNA BCL2L1 apoptosis Homo sapiens colorectal cell 24892549 9606 598 BCL-XL/S|BCL2L|BCLX|BCLXL|BCLXS|Bcl-X|PPP1R52|bcl-xL|bcl-xS HGNC:992|MIM:600039|Ensembl:ENSG00000171552|HPRD:02497|Vega:OTTHUMG00000032192 20 20q11.21 BCL2-like 1 protein-coding BCL2-like 1 We identified YAP1 as a direct miR-375 target in CRC and show that HELLS and NOLC1 are down-stream targets. Knock-down of YAP1 mimicked the phenotype induced by miR-375 over-expression indicating that miR-375 most likely exerts its pro-apoptotic role through YAP1 and its anti-apoptotic down-stream targets BIRC5 and BCL2L1. 1790 miR-375 hsa-miR-375 MIMAT0000728 miRNA BIRC5 apoptosis Homo sapiens colorectal cell 24892549 9606 332 API4|EPR-1 HGNC:593|MIM:603352|Ensembl:ENSG00000089685|HPRD:04520|Vega:OTTHUMG00000177505 17 17q25 baculoviral IAP repeat containing 5 protein-coding baculoviral IAP repeat containing 5 We identified YAP1 as a direct miR-375 target in CRC and show that HELLS and NOLC1 are down-stream targets. Knock-down of YAP1 mimicked the phenotype induced by miR-375 over-expression indicating that miR-375 most likely exerts its pro-apoptotic role through YAP1 and its anti-apoptotic down-stream targets BIRC5 and BCL2L1. 1791 miR-375 hsa-miR-375 MIMAT0000728 miRNA BIRC5 apoptosis Homo sapiens colorectal cell 24892549 9606 332 API4|EPR-1 HGNC:593|MIM:603352|Ensembl:ENSG00000089685|HPRD:04520|Vega:OTTHUMG00000177505 17 17q25 baculoviral IAP repeat containing 5 protein-coding baculoviral IAP repeat containing 5 We identified YAP1 as a direct miR-375 target in CRC and show that HELLS and NOLC1 are down-stream targets. Knock-down of YAP1 mimicked the phenotype induced by miR-375 over-expression indicating that miR-375 most likely exerts its pro-apoptotic role through YAP1 and its anti-apoptotic down-stream targets BIRC5 and BCL2L1. 1792 miR-375 hsa-miR-375 MIMAT0000728 miRNA ESR1 apoptosis up Homo sapiens breast cancer cell 25613180 9606 2099 ER|ESR|ESRA|ESTRR|Era|NR3A1 HGNC:3467|MIM:133430|Ensembl:ENSG00000091831|HPRD:00589|Vega:OTTHUMG00000016103 6 6q25.1 estrogen receptor 1 protein-coding estrogen receptor 1 This study demonstrated that biochanin A promoted ER¦Á-positive cell proliferation through miR-375 activation and this mechanism is possibly involving in a miR-375 and ER¦Á feedback loop. 1793 miR-375 hsa-miR-375 MIMAT0000728 miRNA IGF1R apoptosis down Homo sapiens squamous cell 25184138 9606 3480 CD221|IGFIR|IGFR|JTK13 HGNC:5465|MIM:147370|Ensembl:ENSG00000140443|HPRD:00932|Vega:OTTHUMG00000149851 15 15q26.3 insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor The tumor-suppressive effect of miR-375 was determined by in vitro assays; through gain-of-function studies we demonstrated that miR-375 can inhibit LSCC cell (SNU-48 and SNU-899) proliferation, motility, and invasion, and promote their apoptosis. In addition, bioinformatics tools TargetScan, PicTar, and Miranda were used to investigate the potential target of miR-375; bioinformatics analysis and dual-luciferase reporter assay indicated that IGF1R was a novel direct target of miR-375. Ectopic transfection of miR-375 led to a significant reduction in IGF1R and its downstream signaling molecule AKT at both the mRNA and protein levels in LSCC cells. Our results suggested that downregulation of miR-375 is one of the molecular mechanisms for the development and progression of LSCC by directly targeting IGF1R and affecting its downstream AKT signaling pathways. Furthermore, miR-375 and IGF1R may serve as a novel therapeutic target for LSCC. 1794 miR-375 hsa-miR-375 MIMAT0000728 miRNA MTPN apoptosis down Homo sapiens insulin-secreting NIT-1 cell 20224724 9606 136319 GCDP|V-1 HGNC:15667|MIM:606484|Ensembl:ENSG00000105887|HPRD:07574|Vega:OTTHUMG00000155627 7 7q33 myotrophin protein-coding myotrophin MiR-375 enhances palmitate-induced lipoapoptosis in insulin-secreting NIT-1 cells by repressing myotrophin (V1) protein expression. 1795 miR-375 hsa-miR-375 MIMAT0000728 miRNA PDK1 apoptosis down Homo sapiens gastric carcinoma cells 20215506 9606 5163 - HGNC:8809|MIM:602524|HPRD:03954 2 2q31.1 pyruvate dehydrogenase kinase, isozyme 1 protein-coding pyruvate dehydrogenase kinase, isozyme 1 14-3-3 delta|14-3-3 prote We found that miRNA-375 (miR-375) was the most downregulated and that its ectopic expression in gastric carcinoma cells markedly reduced cell viability via the caspase-mediated apoptosis pathway. Interestingly, we found that expression of miR-375 inhibited expression of PDK1, which is a direct target of miR-375, followed by suppression of Akt phosphorylation. Further analysis by gene expression microarray revealed that 14-3-3zeta, a potent antiapoptotic gene, was significantly downregulated at both the mRNA and protein levels in cells transfected with miR-375. 1796 miR-375 hsa-miR-375 MIMAT0000728 miRNA PDK1 apoptosis down Homo sapiens esophageal 21533613 9606 5163 - HGNC:8809|MIM:602524|HPRD:03954 2 2q31.1 pyruvate dehydrogenase kinase, isozyme 1 protein-coding pyruvate dehydrogenase kinase, isozyme 1 Restoration of the miR-375 expression in esophageal cancer cell lines downregulated the PDK1 expression. Furthermore, the miR-375 expression was found to be inversely correlated with PDK1 expression in esophageal cancer. 1797 miR-375 hsa-miR-375 MIMAT0000728 miRNA TP53 apoptosis down Homo sapiens gastric cancer cells 23835407 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 A luciferase assay demonstrated that miR-375 down-regulated p53 expression through an interaction with the 3' UTR region of p53.Flow cytometry analyses showed that miR-375 abrogated the cell cycle arrest and apoptosis after DNA damage. 1798 miR-375 hsa-miR-375 MIMAT0000728 miRNA YAP1 apoptosis Homo sapiens colorectal cell 24892549 9606 10413 COB1|YAP|YAP2|YAP65|YKI HGNC:16262|MIM:606608|Ensembl:ENSG00000137693|HPRD:09424|Vega:OTTHUMG00000167322 11 11q13 Yes-associated protein 1 protein-coding Yes-associated protein 1 We identified YAP1 as a direct miR-375 target in CRC and show that HELLS and NOLC1 are down-stream targets. Knock-down of YAP1 mimicked the phenotype induced by miR-375 over-expression indicating that miR-375 most likely exerts its pro-apoptotic role through YAP1 and its anti-apoptotic down-stream targets BIRC5 and BCL2L1. 1799 miR-375 hsa-miR-375 MIMAT0000728 miRNA YAP1 apoptosis Homo sapiens colorectal cell 24892549 9606 10413 COB1|YAP|YAP2|YAP65|YKI HGNC:16262|MIM:606608|Ensembl:ENSG00000137693|HPRD:09424|Vega:OTTHUMG00000167322 11 11q13 Yes-associated protein 1 protein-coding Yes-associated protein 1 We identified YAP1 as a direct miR-375 target in CRC and show that HELLS and NOLC1 are down-stream targets. Knock-down of YAP1 mimicked the phenotype induced by miR-375 over-expression indicating that miR-375 most likely exerts its pro-apoptotic role through YAP1 and its anti-apoptotic down-stream targets BIRC5 and BCL2L1. 1800 miR-375 hsa-miR-375 MIMAT0000728 miRNA YWHAZ apoptosis down Homo sapiens gastric carcinoma cells 20215506 9606 7534 14-3-3-zeta|HEL-S-3|HEL4|KCIP-1|YWHAD HGNC:12855|MIM:601288|Ensembl:ENSG00000164924|HPRD:03183|Vega:OTTHUMG00000134291 8 8q23.1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta protein-coding tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 14-3-3 delta|14-3-3 prote We found that miRNA-375 (miR-375) was the most downregulated and that its ectopic expression in gastric carcinoma cells markedly reduced cell viability via the caspase-mediated apoptosis pathway. Interestingly, we found that expression of miR-375 inhibited expression of PDK1, which is a direct target of miR-375, followed by suppression of Akt phosphorylation. Further analysis by gene expression microarray revealed that 14-3-3zeta, a potent antiapoptotic gene, was significantly downregulated at both the mRNA and protein levels in cells transfected with miR-375. 1801 miR-375 hsa-miR-375 MIMAT0000728 miRNA apoptosis Homo sapiens ovarian cancer cell 23696927 9606 Over-expression of mir-375 sensitized the ovarian cancer cells to RAWQ01. Mir-375 enhanced the in vitro sensitivity of ovarian cancer cells to RAWQ01 by inducing apoptosis. Mir-375 also increased the in vivo chemosensitivity of ovarian cancer cells to RAWQ01. 1802 miR-376a hsa-miR-376a-3p,hsa-miR-376a-5p MIMAT0000729,MIMAT0003386 miRNA CASP3 apoptosis up Homo sapiens human retinoblastoma cells 23373993 9606 836 CPP32|CPP32B|SCA-1 HGNC:1504|MIM:600636|Ensembl:ENSG00000164305|HPRD:02799|Vega:OTTHUMG00000133681 4 4q34 caspase 3, apoptosis-related cysteine peptidase protein-coding caspase 3, apoptosis-related cysteine peptidase These results suggest that ATO -induced apoptosis in retinoblastoma cells is part mediated by decreasing expression of miR-376a, which subsequently increased caspase-3 expression. 1803 miR-376a hsa-miR-376a-3p,hsa-miR-376a-5p MIMAT0000729,MIMAT0003386 miRNA PIK3R1 apoptosis Homo sapiens hepatocellular carcinoma cells 22684007 9606 5295 AGM7|GRB1|p85|p85-ALPHA HGNC:8979|MIM:171833|Ensembl:ENSG00000145675|HPRD:01381|Vega:OTTHUMG00000131251 5 5q13.1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) protein-coding phosphoinositide-3-kinase, regulatory subunit 1 (alpha) Over-expression of miR-376a not only inhibited proliferation but induced apoptosis in Huh7 cells. Additionally, p85¦Á (PIK3R1) was identified as a direct and functional target of miR-376a in Huh7 cells. 1804 miR-378 hsa-miR-378a-5p,hsa-miR-378a-3p,hsa-miR-378b,hsa-miR-378c,hsa-miR-378d,hsa-miR-378e,hsa-miR-378f,hsa-miR-378g,hsa-miR-378h,hsa-miR-378i,hsa-miR-378j, MIMAT0000731,MIMAT0000732,MIMAT0014999,MIMAT0016847,MIMAT0018926,MIMAT0018927,MIMAT0018932,MIMAT0018937,MIMAT0018984,MIMAT0019074,MIMAT0024612, miRNA BAX apoptosis up Homo sapiens Mesenchymal stem cell 25418617 9606 581 BCL2L4 HGNC:959|MIM:600040|Ensembl:ENSG00000087088|HPRD:02498|Vega:OTTHUMG00000160476 19 19q13.3-q13.4 BCL2-associated X protein protein-coding BCL2-associated X protein The miR-378 group formed a larger number of vascular branches on matrigel. BCL2 level was decreased accompanied with an upregulated expression of BAX in the two experimental groups under the hypoxic environment. BAX expression was reduced in the miR-378 group under the hypoxic environment. In the miR-378 group, there was a decreased expression of tumor necrosis factor-alpha on protein level and a reduction of TUSC-2 under normoxic environment. Their expressions were both downregulated under hypoxic environment. For the angiogenesis related genes, enhanced expressions of vascular endothelial growth factoralpha, platelet derived growth factor-beta and transforming growth factor-beta1 could be detected both in normoxic and hypoxic-ischemic conditions. 1805 miR-378 hsa-miR-378a-5p,hsa-miR-378a-3p,hsa-miR-378b,hsa-miR-378c,hsa-miR-378d,hsa-miR-378e,hsa-miR-378f,hsa-miR-378g,hsa-miR-378h,hsa-miR-378i,hsa-miR-378j, MIMAT0000731,MIMAT0000732,MIMAT0014999,MIMAT0016847,MIMAT0018926,MIMAT0018927,MIMAT0018932,MIMAT0018937,MIMAT0018984,MIMAT0019074,MIMAT0024612, miRNA BCL2 apoptosis down Homo sapiens Mesenchymal stem cell 25418617 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 The miR-378 group formed a larger number of vascular branches on matrigel. BCL2 level was decreased accompanied with an upregulated expression of BAX in the two experimental groups under the hypoxic environment. BAX expression was reduced in the miR-378 group under the hypoxic environment. In the miR-378 group, there was a decreased expression of tumor necrosis factor-alpha on protein level and a reduction of TUSC-2 under normoxic environment. Their expressions were both downregulated under hypoxic environment. For the angiogenesis related genes, enhanced expressions of vascular endothelial growth factoralpha, platelet derived growth factor-beta and transforming growth factor-beta1 could be detected both in normoxic and hypoxic-ischemic conditions. 1806 miR-378 hsa-miR-378a-5p,hsa-miR-378a-3p,hsa-miR-378b,hsa-miR-378c,hsa-miR-378d,hsa-miR-378e,hsa-miR-378f,hsa-miR-378g,hsa-miR-378h,hsa-miR-378i,hsa-miR-378j MIMAT0000731,MIMAT0000732,MIMAT0014999,MIMAT0016847,MIMAT0018926,MIMAT0018927,MIMAT0018932,MIMAT0018937,MIMAT0018984,MIMAT0019074,MIMAT0024612 miRNA CASP3 apoptosis down Homo sapiens cardiac myocytes 22119805 9606 836 CPP32|CPP32B|SCA-1 HGNC:1504|MIM:600636|Ensembl:ENSG00000164305|HPRD:02799|Vega:OTTHUMG00000133681 4 4q34 caspase 3, apoptosis-related cysteine peptidase protein-coding caspase 3, apoptosis-related cysteine peptidase Overexpression of microRNA-378 attenuates ischemia-induced apoptosis by inhibiting caspase-3 expression in cardiac myocytes. 1807 miR-378 hsa-miR-378a-5p,hsa-miR-378a-3p,hsa-miR-378b,hsa-miR-378c,hsa-miR-378d,hsa-miR-378e,hsa-miR-378f,hsa-miR-378g,hsa-miR-378h,hsa-miR-378i,hsa-miR-378j MIMAT0000731,MIMAT0000732,MIMAT0014999,MIMAT0016847,MIMAT0018926,MIMAT0018927,MIMAT0018932,MIMAT0018937,MIMAT0018984,MIMAT0019074,MIMAT0024612 miRNA CDC40 apoptosis Homo sapiens colorectal cancer. 25328987 9606 51362 EHB3|PRP17|PRPF17 HGNC:17350|MIM:605585|Ensembl:ENSG00000168438|HPRD:05721|Vega:OTTHUMG00000015358 6 6q21 cell division cycle 40 protein-coding cell division cycle 40 MicroRNA-378 inhibits cell growth and enhances L-OHP-induced apoptosis in human colorectal cancer. 1808 miR-378 hsa-miR-378a-5p,hsa-miR-378a-3p,hsa-miR-378b,hsa-miR-378c,hsa-miR-378d,hsa-miR-378e,hsa-miR-378f,hsa-miR-378g,hsa-miR-378h,hsa-miR-378i,hsa-miR-378j MIMAT0000731,MIMAT0000732,MIMAT0014999,MIMAT0016847,MIMAT0018926,MIMAT0018927,MIMAT0018932,MIMAT0018937,MIMAT0018984,MIMAT0019074,MIMAT0024612 miRNA IGF1 apoptosis down Homo sapiens cardiomyocyte 22367207 9606 3479 IGF-I|IGF1A|IGFI HGNC:5464|MIM:147440|Ensembl:ENSG00000017427|HPRD:00936|Vega:OTTHUMG00000149910 12 12q23.2 insulin-like growth factor 1 (somatomedin C) protein-coding insulin-like growth factor 1 (somatomedin C) Overexpression of miR-378 enhanced apoptosis of cardiomyocytes by direct targeting of IGF1R and reduced signaling in Akt cascade. 1809 miR-378 hsa-miR-378a-5p,hsa-miR-378a-3p,hsa-miR-378b,hsa-miR-378c,hsa-miR-378d,hsa-miR-378e,hsa-miR-378f,hsa-miR-378g,hsa-miR-378h,hsa-miR-378i,hsa-miR-378j MIMAT0000731,MIMAT0000732,MIMAT0014999,MIMAT0016847,MIMAT0018926,MIMAT0018927,MIMAT0018932,MIMAT0018937,MIMAT0018984,MIMAT0019074,MIMAT0024612 miRNA apoptosis Homo sapiens 23582927 9606 MicroRNA miR-378 plays important roles in tumorigenesis by enhancing cell survival, reducing apoptosis, promoting tumor growth, angiogenesis and promoting cell migration and invasion. Abnormal expression of miR-378 has been observed in various types of cancers. 1810 miR-378 hsa-miR-378a-5p,hsa-miR-378a-3p,hsa-miR-378b,hsa-miR-378c,hsa-miR-378d,hsa-miR-378e,hsa-miR-378f,hsa-miR-378g,hsa-miR-378h,hsa-miR-378i,hsa-miR-378j MIMAT0000731,MIMAT0000732,MIMAT0014999,MIMAT0016847,MIMAT0018926,MIMAT0018927,MIMAT0018932,MIMAT0018937,MIMAT0018984,MIMAT0019074,MIMAT0024612 miRNA HIPK3 apoptosis Homo sapiens ovarian cancer 24680769 9606 10114 DYRK6|FIST3|PKY|YAK1 HGNC:4915|MIM:604424|Ensembl:ENSG00000110422|HPRD:05111|Vega:OTTHUMG00000132269 11 11p13 homeodomain interacting protein kinase 3 protein-coding homeodomain interacting protein kinase 3 MiR-378 was overexpressed in ovarian cancer cells and tumors vs. normal ovarian epithelial cells. Overexpressing miR-378 in ovarian cancer cells altered expression of genes associated with angiogenesis (ALCAM, EHD1, ELK3, TLN1), apoptosis (RPN2, HIPK3), and cell cycle regulation (SWAP-70, LSM14A, RDX). 1811 miR-378 hsa-miR-378a-5p,hsa-miR-378a-3p,hsa-miR-378b,hsa-miR-378c,hsa-miR-378d,hsa-miR-378e,hsa-miR-378f,hsa-miR-378g,hsa-miR-378h,hsa-miR-378i,hsa-miR-378j MIMAT0000731,MIMAT0000732,MIMAT0014999,MIMAT0016847,MIMAT0018926,MIMAT0018927,MIMAT0018932,MIMAT0018937,MIMAT0018984,MIMAT0019074,MIMAT0024612 miRNA RPN2 apoptosis Homo sapiens ovarian cancer 24680769 9606 6185 RIBIIR|RPN-II|RPNII|SWP1 HGNC:10382|MIM:180490|Ensembl:ENSG00000118705|HPRD:01609|Vega:OTTHUMG00000032409 20 20q12-q13.1 ribophorin II protein-coding ribophorin II MiR-378 was overexpressed in ovarian cancer cells and tumors vs. normal ovarian epithelial cells. Overexpressing miR-378 in ovarian cancer cells altered expression of genes associated with angiogenesis (ALCAM, EHD1, ELK3, TLN1), apoptosis (RPN2, HIPK3), and cell cycle regulation (SWAP-70, LSM14A, RDX). 1812 miR-378a-3p hsa-miR-378a-3p MIMAT0000732 miRNA AKT1 apoptosis Homo sapiens rhabdomyosarcoma cell 25427715 9606 207 AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA HGNC:391|MIM:164730|Ensembl:ENSG00000142208|HPRD:01261|Vega:OTTHUMG00000170795 14 14q32.32 v-akt murine thymoma viral oncogene homolog 1 protein-coding v-akt murine thymoma viral oncogene homolog 1 MiR-378a-3p over-expression in an RMS-derived cell line suppressed IGF1R expression and affected phosphorylated-Akt protein levels. Ectopic expression of miR-378a-3p caused significant changes in apoptosis, cell migration, cytoskeleton organization as well as a modulation of the muscular markers MyoD1, MyoR, desmin and MyHC. In addition, DNA demethylation by 5-aza-2'-deoxycytidine (5-aza-dC) was able to up-regulate miR-378a-3p levels with a concomitant induction of apoptosis, decrease in cell viability and cell cycle arrest in G2-phase. 1813 miR-378a-3p hsa-miR-378a-3p MIMAT0000732 miRNA IGF1R apoptosis down Homo sapiens colorectal cancer cell 24412052 9606 3480 CD221|IGFIR|IGFR|JTK13 HGNC:5465|MIM:147370|Ensembl:ENSG00000140443|HPRD:00932|Vega:OTTHUMG00000149851 15 15q26.3 insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor Ectopic miR-378a-3p or miR-378a-5p expression inhibited cellular proliferation and colony formation, induced apoptosis and G1-phase cell cycle arrest in CRC cells, but had no effect on migration and invasion of CRC cells. Furthermore, miR-378a-3p over-expression or down-regulation could inhibit or enhance insulin-like growth factor 1 receptor (IGF1R) expression in CRC cells. 1814 miR-378a-3p hsa-miR-378a-3p MIMAT0000732 miRNA IGF1R apoptosis down Homo sapiens rhabdomyosarcoma cell 25427715 9606 3480 CD221|IGFIR|IGFR|JTK13 HGNC:5465|MIM:147370|Ensembl:ENSG00000140443|HPRD:00932|Vega:OTTHUMG00000149851 15 15q26.3 insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor MiR-378a-3p over-expression in an RMS-derived cell line suppressed IGF1R expression and affected phosphorylated-Akt protein levels. Ectopic expression of miR-378a-3p caused significant changes in apoptosis, cell migration, cytoskeleton organization as well as a modulation of the muscular markers MyoD1, MyoR, desmin and MyHC. In addition, DNA demethylation by 5-aza-2'-deoxycytidine (5-aza-dC) was able to up-regulate miR-378a-3p levels with a concomitant induction of apoptosis, decrease in cell viability and cell cycle arrest in G2-phase. 1815 miR-378a-5p hsa-miR-378a-5p MIMAT0000731 miRNA IGF1R apoptosis down Homo sapiens colorectal cancer cell 24412052 9606 3480 CD221|IGFIR|IGFR|JTK13 HGNC:5465|MIM:147370|Ensembl:ENSG00000140443|HPRD:00932|Vega:OTTHUMG00000149851 15 15q26.3 insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor Ectopic miR-378a-3p or miR-378a-5p expression inhibited cellular proliferation and colony formation, induced apoptosis and G1-phase cell cycle arrest in CRC cells, but had no effect on migration and invasion of CRC cells. Furthermore, miR-378a-3p over-expression or down-regulation could inhibit or enhance insulin-like growth factor 1 receptor (IGF1R) expression in CRC cells. 1816 miR-381 hsa-miR-381-3p,hsa-miR-381-5p MIMAT0000736,MIMAT0022862 miRNA WEE1 apoptosis down Homo sapiens renal cancer cells 23778472 9606 7465 WEE1A|WEE1hu HGNC:12761|MIM:193525|Ensembl:ENSG00000166483|HPRD:01907|Vega:OTTHUMG00000165863 11 11p15.4 WEE1 G2 checkpoint kinase protein-coding WEE1 G2 checkpoint kinase Simultaneously expressed miR-424 and miR-381 synergistically suppress the proliferation and survival of renal cancer cells---Cdc2 activity is up-regulated by targeting WEE1.We showed that the combination of these miRNAs synergistically inhibited proliferation, abrogated G2/M arrest, and induced apoptosis. This combination led to Cdc2 activation through WEE1 inhibition. 1817 miR-381 hsa-miR-381-3p,hsa-miR-381-5p MIMAT0000736,MIMAT0022862 miRNA WEE1 apoptosis down Homo sapiens renal cancer cells 23816136 9606 7465 WEE1A|WEE1hu HGNC:12761|MIM:193525|Ensembl:ENSG00000166483|HPRD:01907|Vega:OTTHUMG00000165863 11 11p15.4 WEE1 G2 checkpoint kinase protein-coding WEE1 G2 checkpoint kinase miR-381 combined with 5-FU led to Cd c2activation, mitotic catastrophe, and cell apoptosis through inhibitory WEE1. WEE1 was also validated as the direct target of miR-381.miR-381, a novel intrinsic WEE1 inhibitor, sensitizes renal cancer cells to 5-FU by upregulationof Cdc2 activities in 786-O. 1818 miR-383 hsa-miR-383-5p,hsa-miR-383-3p MIMAT0000738,MIMAT0026485 miRNA CCND1 apoptosis down Homo sapiens glioma 25450356 9606 595 BCL1|D11S287E|PRAD1|U21B31 HGNC:1582|MIM:168461|Ensembl:ENSG00000110092|HPRD:01346|Vega:OTTHUMG00000167877 11 11q13 cyclin D1 protein-coding cyclin D1 Overexpression of miR-383 in U251 and U87 cells showed a significant inhibitory effect on cell growth, which accompanied with cell cycle G0/G1 arrest as well as downregulation of CCND1 expression. Moreover, CCND1 was verified to be one of the direct targets of miR-383. 1819 miR-383 hsa-miR-383-5p,hsa-miR-383-3p MIMAT0000738,MIMAT0026485 miRNA PRDX3 apoptosis up Homo sapiens Daoy cells 23157748 9606 10935 AOP-1|AOP1|HBC189|MER5|PRO1748|SP-22|prx-III HGNC:9354|MIM:604769|Ensembl:ENSG00000165672|HPRD:05305|Vega:OTTHUMG00000019146 10 10q25-q26 peroxiredoxin 3 protein-coding peroxiredoxin 3 Up-regulation of miR-383 knockdowns the expression of PRDX3, inhibits proliferation and promotes apoptosis of Daoy cells, leading to increased intracellular ROS and decreased levels of mitochondrial membrane potential. 1820 miR-383 hsa-miR-383-5p,hsa-miR-383-3p MIMAT0000738,MIMAT0026485 miRNA PRDX3 apoptosis down Homo sapiens medulloblastoma cells 23227829 9606 10935 AOP-1|AOP1|HBC189|MER5|PRO1748|SP-22|prx-III HGNC:9354|MIM:604769|Ensembl:ENSG00000165672|HPRD:05305|Vega:OTTHUMG00000019146 10 10q25-q26 peroxiredoxin 3 protein-coding peroxiredoxin 3 Ectopic expression of miR-383 in MB cells led to suppression of cell growth, cell accumulation at sub-G1 phase and alteration of apoptosis-related proteins.we identified peroxiredoxin 3 (PRDX3) as a target gene of miR-383. Luciferase reporter assay confirmed that miR-383 negatively regulated PRDX3 by interaction between miR-383 and complementary sequences in the 3' UTR of PRDX3. 1821 miR-384 hsa-miR-384 MIMAT0001075 miRNA TNFSF10 apoptosis down Homo sapiens NA 20230625 9606 8743 APO2L|Apo-2L|CD253|TL2|TRAIL HGNC:11925|MIM:603598|Ensembl:ENSG00000121858|HPRD:04670|Vega:OTTHUMG00000156917 3 3q26 tumor necrosis factor (ligand) superfamily, member 10 protein-coding tumor necrosis factor (ligand) superfamily, member 10 Transfection of mimics of miR-384 protects several cell types from TRAIL-induced cell death. 1822 miR-3928 hsa-miR-3928-3p,hsa-miR-3928-5p MIMAT0027037,MIMAT0018205 miRNA CDK6 apoptosis down Homo sapiens osteosarcoma cell 24854843 9606 1021 PLSTIRE HGNC:1777|MIM:603368|Ensembl:ENSG00000105810|HPRD:04533|Vega:OTTHUMG00000131697 7 7q21-q22 cyclin-dependent kinase 6 protein-coding cyclin-dependent kinase 6 MiR-3928 was down-regulated in osteosarcoma tissues. Over-expression of miR-3928 inhibited tumor growth, induced cell apoptosis, increased the percent of cells in G1 phrase and decreased the percent of cells in S phrase. Down-regulation of miR-3928 promoted cell proliferation. ERBB3, IL-6R and CDK6 may be the targeted genes of miR-3928. 1823 miR-3928 hsa-miR-3928-3p,hsa-miR-3928-5p MIMAT0027037,MIMAT0018205 miRNA ERBB3 apoptosis down Homo sapiens osteosarcoma cell 24854843 9606 2065 ErbB-3|HER3|LCCS2|MDA-BF-1|c-erbB-3|c-erbB3|erbB3-S|p180-ErbB3|p45-sErbB3|p85-sErbB3 HGNC:3431|MIM:190151|Ensembl:ENSG00000065361|HPRD:01820|Vega:OTTHUMG00000170140 12 12q13 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 protein-coding v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 MiR-3928 was down-regulated in osteosarcoma tissues. Over-expression of miR-3928 inhibited tumor growth, induced cell apoptosis, increased the percent of cells in G1 phrase and decreased the percent of cells in S phrase. Down-regulation of miR-3928 promoted cell proliferation. ERBB3, IL-6R and CDK6 may be the targeted genes of miR-3928. 1824 miR-3928 hsa-miR-3928-3p,hsa-miR-3928-5p MIMAT0027037,MIMAT0018205 miRNA IL6R apoptosis down Homo sapiens osteosarcoma cell 24854843 9606 3570 CD126|IL-6R-1|IL-6RA|IL6Q|IL6RA|IL6RQ|gp80 HGNC:6019|MIM:147880|Ensembl:ENSG00000160712|HPRD:01000|Vega:OTTHUMG00000036073 1 1q21 interleukin 6 receptor protein-coding interleukin 6 receptor MiR-3928 was down-regulated in osteosarcoma tissues. Over-expression of miR-3928 inhibited tumor growth, induced cell apoptosis, increased the percent of cells in G1 phrase and decreased the percent of cells in S phrase. Down-regulation of miR-3928 promoted cell proliferation. ERBB3, IL-6R and CDK6 may be the targeted genes of miR-3928. 1825 miR-409-3p hsa-miR-409-3p MIMAT0001639 miRNA AKT1 apoptosis Homo sapiens lung adenocarcinoma cell 25278243 9606 207 AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA HGNC:391|MIM:164730|Ensembl:ENSG00000142208|HPRD:01261|Vega:OTTHUMG00000170795 14 14q32.32 v-akt murine thymoma viral oncogene homolog 1 protein-coding v-akt murine thymoma viral oncogene homolog 1 Multivariate Cox regression analyses showed that miR-409-3p expression was an independent prognostic factor for LAD patients. Functional analyses indicated that miR-409-3p could inhibit growth, induce apoptosis, reduce migration and invasion in LAD cells via inactivation of Akt signaling by targeting c-Met. 1826 miR-409-3p hsa-miR-409-3p MIMAT0001639 miRNA MET apoptosis Homo sapiens lung adenocarcinoma cell 25278243 9606 4233 AUTS9|HGFR|RCCP2|c-Met HGNC:7029|MIM:164860|Ensembl:ENSG00000105976|HPRD:01280|Vega:OTTHUMG00000023299 7 7q31 MET proto-oncogene, receptor tyrosine kinase protein-coding MET proto-oncogene, receptor tyrosine kinase Multivariate Cox regression analyses showed that miR-409-3p expression was an independent prognostic factor for LAD patients. Functional analyses indicated that miR-409-3p could inhibit growth, induce apoptosis, reduce migration and invasion in LAD cells via inactivation of Akt signaling by targeting c-Met. 1827 miR-409-3p hsa-miR-409-3p MIMAT0001639 miRNA PHF10 apoptosis up Homo sapiens gastric cancer cells 22388101 9606 55274 BAF45A|XAP135 HGNC:18250|MIM:613069|Ensembl:ENSG00000130024|HPRD:11428|Vega:OTTHUMG00000016058 6 6q27 PHD finger protein 10 protein-coding PHD finger protein 10 £¨¼ÓÁËÄÚÈÝ£©Overexpression of miR-409-3p in SGC-7901 gastric cancer cells dramatically suppressed cell proliferation and induced cell apoptosis both in vitro and in vivo. miR-409-3p may function as a novel tumor suppressor in GC and its anti-oncogenic activity may involve the direct targeting and inhibition of PHF10 1828 miR-410 hsa-miR-410-5p,hsa-miR-410-3p MIMAT0002171,MIMAT0026558 miRNA AKT1 apoptosis up Homo sapiens OS cell 25385479 9606 207 AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA HGNC:391|MIM:164730|Ensembl:ENSG00000142208|HPRD:01261|Vega:OTTHUMG00000170795 14 14q32.32 v-akt murine thymoma viral oncogene homolog 1 protein-coding v-akt murine thymoma viral oncogene homolog 1 Further investigation demonstrated the regulation of miR-410 in OS cells via VEGF. In vitro MTT assay, Transwell, and flow cytometry showed that transfection of the miR-410 expression plasmid inhibited cell proliferation and contributed to apoptosis in OS cells. Moreover, restoration of VEGF reversed the effect of miR-410 on OS cells, and upregulated the expression of phosphorylated AKT. Finally, overexpression of miR-410 also showed a negative effect on tumor growth in vivo. 1829 miR-410 hsa-miR-410-5p,hsa-miR-410-3p MIMAT0002171,MIMAT0026558 miRNA VEGFA apoptosis down Homo sapiens OS cell 25385479 9606 7422 MVCD1|VEGF|VPF HGNC:12680|MIM:192240|Ensembl:ENSG00000112715|HPRD:01889|Vega:OTTHUMG00000014745 6 6p12 vascular endothelial growth factor A protein-coding vascular endothelial growth factor A Further investigation demonstrated the regulation of miR-410 in OS cells via VEGF. In vitro MTT assay, Transwell, and flow cytometry showed that transfection of the miR-410 expression plasmid inhibited cell proliferation and contributed to apoptosis in OS cells. Moreover, restoration of VEGF reversed the effect of miR-410 on OS cells, and upregulated the expression of phosphorylated AKT. Finally, overexpression of miR-410 also showed a negative effect on tumor growth in vivo. 1830 miR-421 hsa-miR-421 MIMAT0003339 miRNA CASP3 apoptosis down Homo sapiens gastric cancer cell 25041019 9606 836 CPP32|CPP32B|SCA-1 HGNC:1504|MIM:600636|Ensembl:ENSG00000164305|HPRD:02799|Vega:OTTHUMG00000133681 4 4q34 caspase 3, apoptosis-related cysteine peptidase protein-coding caspase 3, apoptosis-related cysteine peptidase The over-expression of miR-421 promoted gastric cancer cell growth and inhibited apoptosis of the BGC-823 gastric cancer cell line. These observations indicate that miR-421 acts as a tumor promoter by targeting the caspase-3 gene and preventing apoptosis of gastric cancer cells through inhibition of caspase-3 expression. These findings contribute to our understanding of the functions of miR-421 in gastric cancer. 1831 miR-423-3p hsa-miR-423-3p MIMAT0001340 miRNA CASP3 apoptosis Homo sapiens temporal lobe 24751812 9606 836 CPP32|CPP32B|SCA-1 HGNC:1504|MIM:600636|Ensembl:ENSG00000164305|HPRD:02799|Vega:OTTHUMG00000133681 4 4q34 caspase 3, apoptosis-related cysteine peptidase protein-coding caspase 3, apoptosis-related cysteine peptidase Meanwhile, the levels of miR-423-3p and miR-296-5p were correlated with the activity of caspase-3, an apoptosis indicator. Additionally, the loading of miR-423-3p was increased in RNA-induced silencing complex whilst caspase-6, a target of miR-423-3p, was reduced in chronic TLE rats. Collectively, our findings suggest that miRNAs may exert anti-apoptotic effects in chronic TLE. 1832 miR-424 hsa-miR-424-5p,hsa-miR-424-3p MIMAT0001341,MIMAT0004749 miRNA CALU apoptosis down Homo sapiens smooth muscle cell 23447642 9606 813 - HGNC:1458|MIM:603420|HPRD:04569 7 7q32.1 calumenin protein-coding calumenin MiR-424/322 overexpression in vitro inhibited proliferation and migration without affecting apoptosis and prevented VSMC dedifferentiation. Furthermore, miR-424/322 overexpression resulted in decreased expression of its predicted targets: cyclin D1 and Ca(2+)-regulating proteins calumenin and stromal-interacting molecule 1 (STIM1). Using reporter luciferase assays, we confirmed that cyclin D1 and calumenin mRNAs were direct targets of miR-322, whereas miR-322 effect on STIM1 was indirect. 1833 miR-424 hsa-miR-424-3p,hsa-miR-424-5p MIMAT0004749,MIMAT0000549 miRNA CCND1 apoptosis down Homo sapiens smooth muscle cell 23447642 9606 595 BCL1|D11S287E|PRAD1|U21B31 HGNC:1582|MIM:168461|Ensembl:ENSG00000110092|HPRD:01346|Vega:OTTHUMG00000167877 11 11q13 cyclin D1 protein-coding cyclin D1 MiR-424/322 overexpression in vitro inhibited proliferation and migration without affecting apoptosis and prevented VSMC dedifferentiation. Furthermore, miR-424/322 overexpression resulted in decreased expression of its predicted targets: cyclin D1 and Ca(2+)-regulating proteins calumenin and stromal-interacting molecule 1 (STIM1). Using reporter luciferase assays, we confirmed that cyclin D1 and calumenin mRNAs were direct targets of miR-322, whereas miR-322 effect on STIM1 was indirect. 1834 miR-424 hsa-miR-424-5p,hsa-miR-424-3p MIMAT0001341,MIMAT0004749 miRNA CHEK1 apoptosis down Homo sapiens cervical cancer cell 22469983 9606 1111 CHK1 HGNC:1925|MIM:603078|Ensembl:ENSG00000149554|HPRD:04356|Vega:OTTHUMG00000165853 11 11q24.2 checkpoint kinase 1 protein-coding checkpoint kinase 1 Further in vitro observations showed that enforced expression of miR-424 inhibited cell growth by both enhancing apoptosis and blocking G1/S transition, and suppressed cell migration and invasion in two human cervical cancer cell lines, SiHa and CaSki, implying that miR-424 functions as a tumor suppressor in the progression of cervical cancer. Interestingly, overexpression of miR-424 inhibited the expression of protein checkpoint kinase 1 (Chk1) and phosphorylated Chk1 (p-Chk1) at residues Ser345 and decreased the activity of luciferase-reporter containing the 3'-untranslated region (UTR) of Chk1 with predicted miR-424-binding site. 1835 miR-424 hsa-miR-424-5p,hsa-miR-424-3p MIMAT0001341,MIMAT0004749 miRNA LYPLA1 apoptosis down Homo sapiens chronic lymphocytic leukemia (CLL) cell 25670628 9606 10434 APT-1|APT1|LPL-I|LPL1|hAPT1 HGNC:6737|MIM:605599|Ensembl:ENSG00000120992|HPRD:07063|Vega:OTTHUMG00000164313 8 8q11.23 lysophospholipase I protein-coding lysophospholipase I Previously, we could show that miR-138 and -424 are down-regulated in CLL cells. Here, we identified two new target genes, namely acyl protein thioesterase (APT) 1 and 2, which are under control of both miRs and thereby significantly over-expressed in CLL cells.Specific inhibition of APTs by siRNAs, treatment with miRs-138/-424 and pharmacological approaches restore CD95-mediated apoptosis in CLL cells and other cancer cells, pointing to an important regulatory role of APTs in CD95 apoptosis. 1836 miR-424 hsa-miR-424-3p,hsa-miR-424-5p MIMAT0001341,MIMAT0004749 miRNA LYPLA2 apoptosis down Homo sapiens chronic lymphocytic leukemia (CLL) cell 25670628 9606 11313 APT-2|DJ886K2.4 HGNC:6738|Ensembl:ENSG00000011009|HPRD:07127|Vega:OTTHUMG00000002961 1 1p36.11 lysophospholipase II protein-coding lysophospholipase II Previously, we could show that miR-138 and -424 are down-regulated in CLL cells. Here, we identified two new target genes, namely acyl protein thioesterase (APT) 1 and 2, which are under control of both miRs and thereby significantly over-expressed in CLL cells.Specific inhibition of APTs by siRNAs, treatment with miRs-138/-424 and pharmacological approaches restore CD95-mediated apoptosis in CLL cells and other cancer cells, pointing to an important regulatory role of APTs in CD95 apoptosis. 1837 miR-424 hsa-miR-424-5p,hsa-miR-424-3p MIMAT0001341,MIMAT0004749 miRNA PDCD4 apoptosis down Homo sapiens 24967963 9606 27250 H731 HGNC:8763|MIM:608610|Ensembl:ENSG00000150593|HPRD:10549|Vega:OTTHUMG00000019048 10 10q24 programmed cell death 4 (neoplastic transformation inhibitor) protein-coding programmed cell death 4 (neoplastic transformation inhibitor) In this study, we found that hypoxia induces miR-424 expression and that miR-424 in turn suppresses the level of PDCD4 protein, a tumor suppressor that is involved in apoptosis, by targeting its 3' untranslated region. The inhibition of miR-424 enhanced apoptosis and increased the sensitivity of cancer cells to Dox. 1838 miR-424 hsa-miR-424-5p,hsa-miR-424-3p MIMAT0001341,MIMAT0004749 miRNA WEE1 apoptosis down Homo sapiens renal cancer cells 23778472 9606 7465 WEE1A|WEE1hu HGNC:12761|MIM:193525|Ensembl:ENSG00000166483|HPRD:01907|Vega:OTTHUMG00000165863 11 11p15.4 WEE1 G2 checkpoint kinase protein-coding WEE1 G2 checkpoint kinase Simultaneously expressed miR-424 and miR-381 synergistically suppress the proliferation and survival of renal cancer cells---Cdc2 activity is up-regulated by targeting WEE1.We showed that the combination of these miRNAs synergistically inhibited proliferation, abrogated G2/M arrest, and induced apoptosis. This combination led to Cdc2 activation through WEE1 inhibition. 1839 miR-424 hsa-miR-424-5p,hsa-miR-424-3p MIMAT0001341,MIMAT0004749 miRNA ABL1 apoptosis down Homo sapiens K562 cell 25697481 9606 25 ABL|JTK7|bcr/abl|c-ABL|c-ABL1|p150|v-abl HGNC:76|MIM:189980|Ensembl:ENSG00000097007|HPRD:01809|Vega:OTTHUMG00000020813 9 9q34.1 ABL proto-oncogene 1, non-receptor tyrosine kinase protein-coding ABL proto-oncogene 1, non-receptor tyrosine kinase Via luciferase assays, we showed that miR-424 directly targets BCR-ABL. Overexpression of miR-424 was shown to suppress proliferation and induce apoptosis of K562 cells as well as sensitize these cells to imatinib treatment. 1840 miR-424 hsa-miR-424-5p,hsa-miR-424-3p MIMAT0001341,MIMAT0004749 miRNA BCR apoptosis down Homo sapiens K562 cell 25697481 9606 613 ALL|BCR1|CML|D22S11|D22S662|PHL HGNC:1014|MIM:151410|Ensembl:ENSG00000186716|HPRD:01044|Vega:OTTHUMG00000150655 22 22q11.23 breakpoint cluster region protein-coding breakpoint cluster region Via luciferase assays, we showed that miR-424 directly targets BCR-ABL. Overexpression of miR-424 was shown to suppress proliferation and induce apoptosis of K562 cells as well as sensitize these cells to imatinib treatment. 1841 miR-424-5p hsa-miR-424-5p MIMAT0001341 miRNA SOCS6 apoptosis down Homo sapiens pancreatic cancer cells 23653113 9606 9306 CIS-4|CIS4|HSPC060|SOCS-4|SOCS-6|SOCS4|SSI4|STAI4|STATI4 HGNC:16833|MIM:605118|Ensembl:ENSG00000170677|HPRD:05491|Vega:OTTHUMG00000132816 18 18q22.2 suppressor of cytokine signaling 6 protein-coding suppressor of cytokine signaling 6 Results suggested miR-424-5p was significantly upregulated in pancreatic cancer and suppress the expression of SOCS6, and miR-424-5p increased proliferation, migration and invasion of pancreatic cancer cells, while inhibited cell apoptosis. 1842 miR-425 hsa-miR-425-5p,hsa-miR-425-3p MIMAT0003393,MIMAT0001343 miRNA IL1B apoptosis up Homo sapiens gastric cancer cell 24571667 9606 3553 IL-1|IL1-BETA|IL1F2 HGNC:5992|MIM:147720|Ensembl:ENSG00000125538|HPRD:00985|Vega:OTTHUMG00000131344 2 2q14 interleukin 1, beta protein-coding interleukin 1, beta An increase in miR-425 depends on IL-1¦Â-induced NF-kappaB activation, which enhances miR-425 gene transcription upon IL-1¦Â induction. Consequently, repression of phosphatase and tensin homolog by miR-425 promotes gastric cancer cell proliferation, which is required to protect cells from cisplatin-induced apoptosis. Taken together, our data support a critical role for NF-kappaB-dependent upregulation of miR-425, which represents a new pathway for the repression of phosphatase and tensin homolog activation and the promotion of cell survival upon IL-1¦Â induction. 1843 miR-429 hsa-miR-429 MIMAT0001536 miRNA BCL2 apoptosis down Homo sapiens esophageal carcinomas cell 23999873 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 In conclusion, miR-130a is important for maintaining normal autophagy levels and promoting the survival of EPC via regulation of Bcl-2 and Beclin1 expression, via Runx3. MiR-130a may be a regulator linking apoptosis and the autophagy of EPC 1844 miR-429 hsa-miR-429 MIMAT0001536 miRNA NOTCH1 apoptosis down Homo sapiens hepatocellular carcinoma cell 25312821 9606 4851 TAN1|hN1 HGNC:7881|MIM:190198|Ensembl:ENSG00000148400|HPRD:01827|Vega:OTTHUMG00000020935 9 9q34.3 notch 1 protein-coding notch 1 MiR-429 directly targeted NOTCH1 and reduced both mRNA and protein levels of NOTCH1 which stimulated proliferation and suppressed apoptosis in HCC cells. 1845 miR-429 hsa-miR-429 MIMAT0001536 miRNA PLCG1 apoptosis down Homo sapiens breast cancer cell 20514023 9606 5335 NCKAP3|PLC-II|PLC1|PLC148|PLCgamma1 HGNC:9065|MIM:172420|Ensembl:ENSG00000124181|HPRD:01398|Vega:OTTHUMG00000033082 20 20q12-q13.1 phospholipase C, gamma 1 protein-coding phospholipase C, gamma 1 This identified phospholipase C gamma 1 (PLCG1), which was downregulated only by the miR-200bc/429 cluster, as a potential candidate contributing to these phenotypical differences. Luciferase reporter assays validated PLCG1 as a direct functional target of miR-200bc/429 cluster, but not of miR-200a/141 cluster. Finally, loss of PLCG1 in part mimicked the effect of miR-200bc/429 overexpression in viability, apoptosis and EGF-driven cell invasion of breast cancer cells. Our results suggest that the miR-200 family has a tumor-suppressor function by negatively regulating EGF-driven cell invasion, viability and cell cycle progression in breast cancer. 1846 miR-429 hsa-miR-429 MIMAT0001536 miRNA SOX2 apoptosis down Homo sapiens colorectal cancer cell 23111103 9606 6657 ANOP3|MCOPS3 HGNC:11195|MIM:184429|Ensembl:ENSG00000181449|HPRD:08921|Vega:OTTHUMG00000158222 3 3q26.3-q27 SRY (sex determining region Y)-box 2 protein-coding SRY (sex determining region Y)-box 2 functionally, miR-429 overexpression suppressed cell apoptosis by directly targeting SOX2 in HT-29 cells. 1847 miR-429 hsa-miR-429 MIMAT0001536 miRNA SP1 apoptosis down Homo sapiens esophageal carcinomas cell 23999873 9606 6667 - HGNC:11205|MIM:189906|Ensembl:ENSG00000185591|HPRD:01796|Vega:OTTHUMG00000170047 12 12q13.1 Sp1 transcription factor protein-coding Sp1 transcription factor In primary EC tissues miR-429 is expressed at low levels. Up-regulation of miR-429 inhibits invasion and promotes apoptosis in EC cells by targeting Bcl-2 and SP1. Our findings suggest that Bcl-2 and SP1 may serve as major targets of miR-429. 1848 miR-429 hsa-miR-429 MIMAT0001536 miRNA ZEB1 apoptosis down Homo sapiens osteosarcoma cell 24633485 9606 6935 AREB6|BZP|DELTAEF1|FECD6|NIL2A|PPCD3|TCF8|ZFHEP|ZFHX1A HGNC:11642|MIM:189909|Ensembl:ENSG00000148516|HPRD:01798|Vega:OTTHUMG00000017907 10 10p11.2 zinc finger E-box binding homeobox 1 protein-coding zinc finger E-box binding homeobox 1 MiR-429 can inhibit the proliferation of osteosarcoma cell lines and induce more cell apoptosis. Also, we discovered MiR-429 plays a role in osteosarcoma by binding the 3'UTR of zinc finger E-box-binding homeobox 1 (ZEB1) mRNA, and that overexpression of ZEB1 could reverse the proliferation, subsequently blocking effect of miR-429. 1849 miR-429 hsa-miR-429 MIMAT0001536 miRNA ZEB1 apoptosis down Homo sapiens Oral squamous cell 25640197 9606 6935 AREB6|BZP|DELTAEF1|FECD6|NIL2A|PPCD3|TCF8|ZFHEP|ZFHX1A HGNC:11642|MIM:189909|Ensembl:ENSG00000148516|HPRD:01798|Vega:OTTHUMG00000017907 10 10p11.2 zinc finger E-box binding homeobox 1 protein-coding zinc finger E-box binding homeobox 1 MiR-429 was down-regulated in OSCC tissues, and miR-429 overexpression inhibited OSCC cell lines growth and vice versa. Further, we found that miR-429 could inhibit zinc finger E-boxbinding homeobox 1 (ZEB1) expression, and that miR-429 and ZEB1 expression in OSCC tissues were negatively correlated. 1850 miR-429 hsa-miR-429 MIMAT0001536 miRNA apoptosis Homo sapiens gastric cancer cell line cells 23554776 9606 Overexpression of miR-429 promoted tumor cell apoptosis when compared with mock transfected cells (P < 0.05).On the contrary, miR-429 inhibitor promoted tumor cell proliferation and inhibited apoptosis when compared with controls (P < 0.05). 1851 miR-432 hsa-miR-432-5p MIMAT0002814 miRNA apoptosis Homo sapiens 25707426 9606 9606 We validated the functional impacts of selected DE miRNAs in CD16- monocytes, overexpression of miR-432 significantly increases apoptosis, and inhibiting miR-19a significantly reduces cell motility. 1852 miR-4448 hsa-miR-4448 MIMAT0018967 miRNA BMI1 apoptosis down Homo sapiens AGS/HepG2 cell 24861464 9606 648 FLVI2/BMI1|PCGF4|RNF51 HGNC:1066|MIM:164831|Ensembl:ENSG00000168283|HPRD:01277|Vega:OTTHUMG00000017807 10 10p11.23 BMI1 proto-oncogene, polycomb ring finger protein-coding BMI1 proto-oncogene, polycomb ring finger MiR-302a and miR-4448 were markedly upregulated by treatment with SAHA and DZNep, respectively. DYRK1A, CDK2, BMI-1 and Girdin, which are targets of miR-1246, miR-302a and miR-4448, were suppressed by treatment with SAHA and DZNep, leading to apoptosis, cell cycle arrest and reduced migration of AGS and HepG2 cells. 1853 miR-4448 hsa-miR-4448 MIMAT0018967 miRNA CCDC88A apoptosis down Homo sapiens AGS/HepG2 cell 24861464 9606 55704 APE|GIRDIN|GIV|GRDN|HkRP1|KIAA1212 HGNC:25523|MIM:609736|Ensembl:ENSG00000115355|HPRD:10051|HPRD:11131|Vega:OTTHUMG00000151915 2 2p16.1 coiled-coil domain containing 88A protein-coding coiled-coil domain containing 88A MiR-302a and miR-4448 were markedly upregulated by treatment with SAHA and DZNep, respectively. DYRK1A, CDK2, BMI-1 and Girdin, which are targets of miR-1246, miR-302a and miR-4448, were suppressed by treatment with SAHA and DZNep, leading to apoptosis, cell cycle arrest and reduced migration of AGS and HepG2 cells. 1854 miR-4448 hsa-miR-4448 MIMAT0018967 miRNA CDK2 apoptosis down Homo sapiens AGS/HepG2 cell 24861464 9606 1017 CDKN2|p33(CDK2) HGNC:1771|MIM:116953|Ensembl:ENSG00000123374|HPRD:00310|Vega:OTTHUMG00000170575 12 12q13 cyclin-dependent kinase 2 protein-coding cyclin-dependent kinase 2 MiR-302a and miR-4448 were markedly upregulated by treatment with SAHA and DZNep, respectively. DYRK1A, CDK2, BMI-1 and Girdin, which are targets of miR-1246, miR-302a and miR-4448, were suppressed by treatment with SAHA and DZNep, leading to apoptosis, cell cycle arrest and reduced migration of AGS and HepG2 cells. 1855 miR-4448 hsa-miR-4448 MIMAT0018967 miRNA DYRK1A apoptosis down Homo sapiens AGS/HepG2 cell 24861464 9606 1859 DYRK|DYRK1|HP86|MNB|MNBH|MRD7 HGNC:3091|MIM:600855|Ensembl:ENSG00000157540|HPRD:09018|Vega:OTTHUMG00000086657 21 21q22.13 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A protein-coding dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A MiR-302a and miR-4448 were markedly upregulated by treatment with SAHA and DZNep, respectively. DYRK1A, CDK2, BMI-1 and Girdin, which are targets of miR-1246, miR-302a and miR-4448, were suppressed by treatment with SAHA and DZNep, leading to apoptosis, cell cycle arrest and reduced migration of AGS and HepG2 cells. 1856 miR-449 hsa-miR-449c-5p,hsa-miR-449c-3p,hsa-miR-449a,hsa-miR-449b-5p,hsa-miR-449b-3p MIMAT0001541,MIMAT0010251,MIMAT0013771,MIMAT0003327,MIMAT0009203 miRNA CASP3 apoptosis up Homo sapiens gastric cancer cell 21418558 9606 836 CPP32|CPP32B|SCA-1 HGNC:1504|MIM:600636|Ensembl:ENSG00000164305|HPRD:02799|Vega:OTTHUMG00000133681 4 4q34 caspase 3, apoptosis-related cysteine peptidase protein-coding caspase 3, apoptosis-related cysteine peptidase We also show that miR-449 over-expression activated p53 and its downstream target p21 as well as the apoptosis markers cleaved CASP3 and PARP. Importantly, qPCR analyses showed a loss of miR-449 expression in human clinical gastric tumours compared to normal tissues. 1857 miR-449 hsa-miR-449c-5p,hsa-miR-449c-3p,hsa-miR-449a,hsa-miR-449b-5p,hsa-miR-449b-3p MIMAT0001541,MIMAT0010251,MIMAT0013771,MIMAT0003327,MIMAT0009203 miRNA CDKN1A apoptosis up Homo sapiens gastric cancer cell 21418558 9606 1026 CAP20|CDKN1|CIP1|MDA-6|P21|SDI1|WAF1|p21CIP1 HGNC:1784|MIM:116899|Ensembl:ENSG00000124762|HPRD:00298|Vega:OTTHUMG00000014603 6 6p21.2 cyclin-dependent kinase inhibitor 1A (p21, Cip1) protein-coding cyclin-dependent kinase inhibitor 1A (p21, Cip1) We also show that miR-449 over-expression activated p53 and its downstream target p21 as well as the apoptosis markers cleaved CASP3 and PARP. Importantly, qPCR analyses showed a loss of miR-449 expression in human clinical gastric tumours compared to normal tissues. 1858 miR-449 hsa-miR-449c-5p,hsa-miR-449c-3p,hsa-miR-449a,hsa-miR-449b-5p,hsa-miR-449b-3p MIMAT0001541,MIMAT0010251,MIMAT0013771,MIMAT0003327,MIMAT0009203 miRNA PARP1 apoptosis up Homo sapiens gastric cancer cell 21418558 9606 142 ADPRT|ADPRT 1|ADPRT1|ARTD1|PARP|PARP-1|PPOL|pADPRT-1 HGNC:270|MIM:173870|Ensembl:ENSG00000143799|HPRD:01435|Vega:OTTHUMG00000037556 1 1q41-q42 poly (ADP-ribose) polymerase 1 protein-coding poly (ADP-ribose) polymerase 1 We also show that miR-449 over-expression activated p53 and its downstream target p21 as well as the apoptosis markers cleaved CASP3 and PARP. Importantly, qPCR analyses showed a loss of miR-449 expression in human clinical gastric tumours compared to normal tissues. 1859 miR-449 hsa-miR-449c-5p,hsa-miR-449c-3p,hsa-miR-449a,hsa-miR-449b-5p,hsa-miR-449b-3p MIMAT0001541,MIMAT0010251,MIMAT0013771,MIMAT0003327,MIMAT0009203 miRNA TP53 apoptosis up Homo sapiens gastric cancer cell 21418558 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 We also show that miR-449 over-expression activated p53 and its downstream target p21 as well as the apoptosis markers cleaved CASP3 and PARP. Importantly, qPCR analyses showed a loss of miR-449 expression in human clinical gastric tumours compared to normal tissues. 1860 miR-449 hsa-miR-449a,hsa-miR-449b-5p,hsa-miR-449b-3p,hsa-miR-449c-5p,hsa-miR-4 MIMAT0001541,MIMAT0003327,MIMAT0009203,MIMAT001025 miRNA apoptosis Homo sapiens 23028477 9606 Coherent with the experiments it predicts that miR449 plays a critical role in regulating the cell cycle progression and provides a twofold safety mechanism to avoid excessive E2F-induced proliferation by cell cycle arrest and apoptosis. 1861 miR-449a hsa-miR-449a MIMAT0001541 miRNA AKT1 apoptosis down Homo sapiens glioblastoma cell 25487955 9606 207 AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA HGNC:391|MIM:164730|Ensembl:ENSG00000142208|HPRD:01261|Vega:OTTHUMG00000170795 14 14q32.32 v-akt murine thymoma viral oncogene homolog 1 protein-coding v-akt murine thymoma viral oncogene homolog 1 Functionally, miR-449a acted as a tumor suppressor by reducing cell proliferation, migration and invasion as well as inducing apoptosis in human GBM cell lines and GSCs. Myc-associated zinc-finger protein (MAZ) was identified as a direct target of miR-449a, mediating these tumor-suppressive effects, demonstrated by Western blot assay and luciferase assays. Moreover, over-expression of miR-449a inhibited the expression of Podoplanin (PDPN) by down-regulating MAZ which could positively control the promoter activities via binding to the promoter of PDPN, demonstrated by luciferase assays and chromatin immunoprecipitation assays. Further, the PI3K/AKT pathway was blocked when MAZ was down-regulated by miR-449a. This process was coincided with the up-regulation of apoptotic proteins and the down-regulation of anti-apoptotic proteins, MMP2 and MMP9. 1862 miR-449a hsa-miR-449a MIMAT0001541 miRNA BCL2 apoptosis down Homo sapiens gastric 24260067 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Subsequently, Bcl-2 was identified as a potential miR-449a target by bioinformatics analysis. It was also shown that Bcl-2 was negatively regulated by miR-449a at the post-transcriptional level, via a specific target site within the 3'-untranslated region (3'UTR), by luciferase reporter assay. 1863 miR-449a hsa-miR-449a MIMAT0001541 miRNA CDC25A apoptosis down Homo sapiens HEC-1B cell 24993091 9606 993 CDC25A2 HGNC:1725|MIM:116947|Ensembl:ENSG00000164045|HPRD:00305|Vega:OTTHUMG00000133535 3 3p21 cell division cycle 25A protein-coding cell division cycle 25A We analyzed the effects of miR-449a overexpression on CDC25 expression, proliferation, invasion and apoptosis of HEC-1B cells. We found that miR-449a and miR-449b levels were markedly reduced in type?II endometrial cancer tissues but not in type?I endometrial cancer tissues compared with normal endometrium. Overexpression of miR-449a significantly inhibited the proliferation, invasion and clonogenic survival of HEC-1B cells. MiR-449a overexpression also induced apoptosis in HEC-1B cells. In addition, real-time RT-PCR and western blot analysis showed that CDC25A expression was suppressed by miR-449a overexpression. Our results suggest that miR-449a may act as a tumor suppressor by targeting CDC25A in endometrial cancer. 1864 miR-449a hsa-miR-449a MIMAT0001541 miRNA CDK6 apoptosis down Homo sapiens gastric cancer cell 25202363 9606 1021 PLSTIRE HGNC:1777|MIM:603368|Ensembl:ENSG00000105810|HPRD:04533|Vega:OTTHUMG00000131697 7 7q21-q22 cyclin-dependent kinase 6 protein-coding cyclin-dependent kinase 6 The level of MGC-803 cell proliferation was decreased and the apoptosis level was increased by the upregulation of miR-449a expression, and the opposite effect was shown by the downregulation of expression. The expression of the CDK6 protein in the MGC-803 cells was downregulated by upregulating the expression of miR-449a. 1865 miR-449a hsa-miR-449a MIMAT0001541 miRNA CDKN2B-AS1 apoptosis down Homo sapiens gastric 25504755 9606 100048912 ANRIL|CDKN2B-AS|CDKN2BAS|NCRNA00089|PCAT12|p15AS HGNC:34341|MIM:613149|Ensembl:ENSG00000240498 9 9p21.3 CDKN2B antisense RNA 1 ncRNA CDKN2B antisense RNA 1 Our previous study showed that ANRIL was significantly upregulated in gastric cancer, and it could promote cell proliferation and inhibit cell apoptosis by silencing of miR99a and miR449a transcription. 1866 miR-449a hsa-miR-449a MIMAT0001541 miRNA E2F1 apoptosis Homo sapiens colorectal carcinoma cells 19960022 9606 1869 E2F-1|RBAP1|RBBP3|RBP3 HGNC:3113|MIM:189971|Ensembl:ENSG00000101412|HPRD:01806|Vega:OTTHUMG00000032265 20 20q11.2 E2F transcription factor 1 protein-coding E2F transcription factor 1 NAD-dependent deacetylase E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosis. 1867 miR-449a hsa-miR-449a MIMAT0001541 miRNA MAZ apoptosis down Homo sapiens glioblastoma cell 25487955 9606 4150 PUR1|Pur-1|SAF-1|SAF-2|SAF-3|ZF87|ZNF801|Zif87 HGNC:6914|MIM:600999|Ensembl:ENSG00000103495|HPRD:02999|Vega:OTTHUMG00000132119 16 16p11.2 MYC-associated zinc finger protein (purine-binding transcription factor) protein-coding MYC-associated zinc finger protein (purine-binding transcription factor) Functionally, miR-449a acted as a tumor suppressor by reducing cell proliferation, migration and invasion as well as inducing apoptosis in human GBM cell lines and GSCs. Myc-associated zinc-finger protein (MAZ) was identified as a direct target of miR-449a, mediating these tumor-suppressive effects, demonstrated by Western blot assay and luciferase assays. Moreover, over-expression of miR-449a inhibited the expression of Podoplanin (PDPN) by down-regulating MAZ which could positively control the promoter activities via binding to the promoter of PDPN, demonstrated by luciferase assays and chromatin immunoprecipitation assays. Further, the PI3K/AKT pathway was blocked when MAZ was down-regulated by miR-449a. This process was coincided with the up-regulation of apoptotic proteins and the down-regulation of anti-apoptotic proteins, MMP2 and MMP9. 1868 miR-449a hsa-miR-449a MIMAT0001541 miRNA MET apoptosis down Homo sapiens non-small cell lung cancercell 23734217 9606 4233 AUTS9|HGFR|RCCP2|c-Met HGNC:7029|MIM:164860|Ensembl:ENSG00000105976|HPRD:01280|Vega:OTTHUMG00000023299 7 7q31 MET proto-oncogene, receptor tyrosine kinase protein-coding MET proto-oncogene, receptor tyrosine kinase MicroRNA-449a is downregulated in non-small cell lung cancer and inhibits migration and invasion by targeting c-Met. 1869 miR-449a hsa-miR-449a MIMAT0001541 miRNA MMP2 apoptosis down Homo sapiens glioblastoma cell 25487955 9606 4313 CLG4|CLG4A|MMP-II|MONA|TBE-1 HGNC:7166|MIM:120360|Ensembl:ENSG00000087245|HPRD:00386|Vega:OTTHUMG00000133202 16 16q13-q21 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) protein-coding matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) Functionally, miR-449a acted as a tumor suppressor by reducing cell proliferation, migration and invasion as well as inducing apoptosis in human GBM cell lines and GSCs. Myc-associated zinc-finger protein (MAZ) was identified as a direct target of miR-449a, mediating these tumor-suppressive effects, demonstrated by Western blot assay and luciferase assays. Moreover, over-expression of miR-449a inhibited the expression of Podoplanin (PDPN) by down-regulating MAZ which could positively control the promoter activities via binding to the promoter of PDPN, demonstrated by luciferase assays and chromatin immunoprecipitation assays. Further, the PI3K/AKT pathway was blocked when MAZ was down-regulated by miR-449a. This process was coincided with the up-regulation of apoptotic proteins and the down-regulation of anti-apoptotic proteins, MMP2 and MMP9. 1870 miR-449a hsa-miR-449a MIMAT0001541 miRNA MMP9 apoptosis down Homo sapiens glioblastoma cell 25487955 9606 4318 CLG4B|GELB|MANDP2|MMP-9 HGNC:7176|MIM:120361|Ensembl:ENSG00000100985|HPRD:00387|Vega:OTTHUMG00000033044 20 20q11.2-q13.1 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) protein-coding matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) Functionally, miR-449a acted as a tumor suppressor by reducing cell proliferation, migration and invasion as well as inducing apoptosis in human GBM cell lines and GSCs. Myc-associated zinc-finger protein (MAZ) was identified as a direct target of miR-449a, mediating these tumor-suppressive effects, demonstrated by Western blot assay and luciferase assays. Moreover, over-expression of miR-449a inhibited the expression of Podoplanin (PDPN) by down-regulating MAZ which could positively control the promoter activities via binding to the promoter of PDPN, demonstrated by luciferase assays and chromatin immunoprecipitation assays. Further, the PI3K/AKT pathway was blocked when MAZ was down-regulated by miR-449a. This process was coincided with the up-regulation of apoptotic proteins and the down-regulation of anti-apoptotic proteins, MMP2 and MMP9. 1871 miR-449a hsa-miR-449a MIMAT0001541 miRNA NOTCH1 apoptosis down Homo sapiens ovarian cancer cell 25179844 9606 4851 TAN1|hN1 HGNC:7881|MIM:190198|Ensembl:ENSG00000148400|HPRD:01827|Vega:OTTHUMG00000020935 9 9q34.3 notch 1 protein-coding notch 1 The overexpression of miR-449a increased cisplatin sensitivity of SKOV3/DDP and A2780/DDP cells by inhibiting proliferation and promoting apoptosis. The luciferase assay confirmed that miR-449a functioned through suppressing NOTCH1 directly. 1872 miR-449a hsa-miR-449a MIMAT0001541 miRNA PDPN apoptosis down Homo sapiens glioblastoma cell 25487955 9606 10630 AGGRUS|GP36|GP40|Gp38|HT1A-1|OTS8|PA2.26|T1A|T1A-2|T1A2|TI1A HGNC:29602|MIM:608863|Ensembl:ENSG00000162493|HPRD:16398|Vega:OTTHUMG00000007912 1 1p36.21 podoplanin protein-coding podoplanin Functionally, miR-449a acted as a tumor suppressor by reducing cell proliferation, migration and invasion as well as inducing apoptosis in human GBM cell lines and GSCs. Myc-associated zinc-finger protein (MAZ) was identified as a direct target of miR-449a, mediating these tumor-suppressive effects, demonstrated by Western blot assay and luciferase assays. Moreover, over-expression of miR-449a inhibited the expression of Podoplanin (PDPN) by down-regulating MAZ which could positively control the promoter activities via binding to the promoter of PDPN, demonstrated by luciferase assays and chromatin immunoprecipitation assays. Further, the PI3K/AKT pathway was blocked when MAZ was down-regulated by miR-449a. This process was coincided with the up-regulation of apoptotic proteins and the down-regulation of anti-apoptotic proteins, MMP2 and MMP9. 1873 miR-449a hsa-miR-449a MIMAT0001541 miRNA PIK3CA apoptosis down Homo sapiens glioblastoma cell 25487955 9606 5290 CLOVE|CWS5|MCAP|MCM|MCMTC|PI3K|p110-alpha HGNC:8975|MIM:171834|HPRD:01382 3 3q26.3 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha protein-coding phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha Functionally, miR-449a acted as a tumor suppressor by reducing cell proliferation, migration and invasion as well as inducing apoptosis in human GBM cell lines and GSCs. Myc-associated zinc-finger protein (MAZ) was identified as a direct target of miR-449a, mediating these tumor-suppressive effects, demonstrated by Western blot assay and luciferase assays. Moreover, over-expression of miR-449a inhibited the expression of Podoplanin (PDPN) by down-regulating MAZ which could positively control the promoter activities via binding to the promoter of PDPN, demonstrated by luciferase assays and chromatin immunoprecipitation assays. Further, the PI3K/AKT pathway was blocked when MAZ was down-regulated by miR-449a. This process was coincided with the up-regulation of apoptotic proteins and the down-regulation of anti-apoptotic proteins, MMP2 and MMP9. 1874 miR-449a hsa-miR-449a MIMAT0001541 miRNA TNFSF10 apoptosis up Homo sapiens lung cancer cell 25132116 9606 8743 APO2L|Apo-2L|CD253|TL2|TRAIL HGNC:11925|MIM:603598|Ensembl:ENSG00000121858|HPRD:04670|Vega:OTTHUMG00000156917 3 3q26 tumor necrosis factor (ligand) superfamily, member 10 protein-coding tumor necrosis factor (ligand) superfamily, member 10 TRAIL also induces apoptosis in normal cells and therefore may cause toxicity to normal tissues if clinically applied. To address this issue, we inserted microRNA response elements (MREs) of miR-133a, miR-137 and miR-449a, which are all underexpressed in lung cancer cells, into an adenoviral vector to regulate TRAIL expression. This MRE-regulated vector (Ad-TRAIL-MRE) was able to express TRAIL in a lung-cancer-specific fashion. No TRAIL expression was detected in normal cells. Consistently, Ad-TRAIL-MRE exerted cytotoxicity to lung cancer cells, rather than normal cells, perhaps via inducing selective apoptosis. 1875 miR-449a hsa-miR-449a MIMAT0001541 miRNA apoptosis Homo sapiens adenocarcinoma cell 23614048 9606 Overexpression of miR-449a in CL1-0 cells effectively increased irradiation-induced DNA damage and apoptosis, altered the cell cycle distribution and eventually led to sensitization of CL1-0 to irradiation. 1876 miR-449a hsa-miR-449a MIMAT0001541 miRNA apoptosis Homo sapiens retinoblastoma cell 24120948 9606 The purpose of our study is to illustrate the relationship between the expressions of miRs-449a and -449b to retinoblastoma proliferation and apoptosis. We are the first to confirm an inhibitory effect of miR-449a and -449b in retinoblastoma by demonstrating significantly impaired proliferation and increased apoptosis of tumor cells when these miRNAs are overexpressed. 1877 miR-449a hsa-miR-449a MIMAT0001541 miRNA apoptosis Homo sapiens 24140040 9606 Bioinformatics analysis showed that five microRNAs (hsa-mir-34b*, hsa-mir-34b, hsa-mir-34c-5p, hsa-mir-449a, and hsa-mir-449b*) were involved in apoptosis, cell proliferation, and differentiation. 1878 miR-449b hsa-miR-449b-5p,hsa-miR-449b-3p MIMAT0003327,MIMAT0009203 miRNA E2F1 apoptosis Homo sapiens colorectal carcinoma cells 19960022 9606 1869 E2F-1|RBAP1|RBBP3|RBP3 HGNC:3113|MIM:189971|Ensembl:ENSG00000101412|HPRD:01806|Vega:OTTHUMG00000032265 20 20q11.2 E2F transcription factor 1 protein-coding E2F transcription factor 1 cell division protein kin E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosis. 1879 miR-449b hsa-miR-449b-5p,hsa-miR-449b-3p MIMAT0003327,MIMAT0009203 miRNA apoptosis Homo sapiens retinoblastoma cell 24120948 9606 The purpose of our study is to illustrate the relationship between the expressions of miRs-449a and -449b to retinoblastoma proliferation and apoptosis. We are the first to confirm an inhibitory effect of miR-449a and -449b in retinoblastoma by demonstrating significantly impaired proliferation and increased apoptosis of tumor cells when these miRNAs are overexpressed. 1880 miR-449b-3p hsa-miR-449b-3p MIMAT0009203 miRNA apoptosis Homo sapiens 24140040 9606 Bioinformatics analysis showed that five microRNAs (hsa-mir-34b*, hsa-mir-34b, hsa-mir-34c-5p, hsa-mir-449a, and hsa-mir-449b*) were involved in apoptosis, cell proliferation, and differentiation. 1881 miR-4500 hsa-miR-4500 MIMAT0019036 miRNA LIN28B apoptosis Homo sapiens non-small cell lung cancer cell 25277326 9606 389421 CSDD2 HGNC:32207|MIM:611044|Ensembl:ENSG00000187772|HPRD:13366|Vega:OTTHUMG00000015290 6 6q21 lin-28 homolog B (C. elegans) protein-coding lin-28 homolog B (C. elegans) MiR-4500 overexpression inhibited NSCLC proliferation and induced apoptosis and vice versa. LIN28B and NRAS were targeted by miR-4500. 1882 miR-4500 hsa-miR-4500 MIMAT0019036 miRNA NRAS apoptosis Homo sapiens non-small cell lung cancer cell 25277326 9606 4893 ALPS4|CMNS|N-ras|NCMS|NRAS1|NS6 HGNC:7989|MIM:164790|Ensembl:ENSG00000213281|HPRD:01273|Vega:OTTHUMG00000012059 1 1p13.2 neuroblastoma RAS viral (v-ras) oncogene homolog protein-coding neuroblastoma RAS viral (v-ras) oncogene homolog MiR-4500 overexpression inhibited NSCLC proliferation and induced apoptosis and vice versa. LIN28B and NRAS were targeted by miR-4500. 1883 miR-451 hsa-miR-451a,hsa-miR-451b MIMAT0001631,MIMAT0019840 miRNA AKT1 apoptosis down Homo sapiens glioma cell 20816946 9606 207 AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA HGNC:391|MIM:164730|Ensembl:ENSG00000142208|HPRD:01261|Vega:OTTHUMG00000170795 14 14q32.32 v-akt murine thymoma viral oncogene homolog 1 protein-coding v-akt murine thymoma viral oncogene homolog 1 Akt1, CyclinD1, MMP-2, MMP-9 and Bcl-2 protein expression decreased, and p27 expression increased in a dose-dependent manner with miR-451 mimics oligonucleotides. Taken together, these studies reveal miR-451 impacts glioblastoma cell proliferation, invasion and apoptosis, perhaps via regulation of the PI3K/AKT signaling pathway. 1884 miR-451 hsa-mir-451b,hsa-miR-451a MIMAT0019840,MIMAT0001631 miRNA AKT1 apoptosis down Homo sapiens esophageal carcinoma cell 23053883 9606 207 AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA HGNC:391|MIM:164730|Ensembl:ENSG00000142208|HPRD:01261|Vega:OTTHUMG00000170795 14 14q32.32 v-akt murine thymoma viral oncogene homolog 1 protein-coding v-akt murine thymoma viral oncogene homolog 1 In comparison to the controls, a significant increase in the expression of miR-451 was associated with significantly decreased expressions of Bcl-2, AKT and p-AKT, and a significant increase in the apoptosis rate. 1885 miR-451 hsa-miR-451a,hsa-miR-451b MIMAT0001631,MIMAT0019840 miRNA AKT1 apoptosis down Homo sapiens 23886157 9606 207 AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA HGNC:391|MIM:164730|Ensembl:ENSG00000142208|HPRD:01261|Vega:OTTHUMG00000170795 14 14q32.32 v-akt murine thymoma viral oncogene homolog 1 protein-coding v-akt murine thymoma viral oncogene homolog 1 In comparison to the controls, a significant increase in the expression of miR-451 was associated with significantly decreased expression of CAB39, LKB1, AMPK, AKT, PI3K and Bcl2. 1886 miR-451 hsa-miR-451a,hsa-miR-451b MIMAT0001631,MIMAT0019840 miRNA BCL2 apoptosis down Homo sapiens glioma cell 20816946 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Akt1, CyclinD1, MMP-2, MMP-9 and Bcl-2 protein expression decreased, and p27 expression increased in a dose-dependent manner with miR-451 mimics oligonucleotides. Taken together, these studies reveal miR-451 impacts glioblastoma cell proliferation, invasion and apoptosis, perhaps via regulation of the PI3K/AKT signaling pathway. 1887 miR-451 hsa-mir-451b,hsa-miR-451a MIMAT0019840,MIMAT0001631 miRNA BCL2 apoptosis down Homo sapiens esophageal carcinoma cell 23053883 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 In comparison to the controls, a significant increase in the expression of miR-451 was associated with significantly decreased expressions of Bcl-2, AKT and p-AKT, and a significant increase in the apoptosis rate. 1888 miR-451 hsa-miR-451a,hsa-miR-451b MIMAT0001631,MIMAT0019840 miRNA BCL2 apoptosis down Homo sapiens 23886157 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 In comparison to the controls, a significant increase in the expression of miR-451 was associated with significantly decreased expression of CAB39, LKB1, AMPK, AKT, PI3K and Bcl2. 1889 miR-451 hsa-miR-451a,hsa-miR-451b MIMAT0019840,MIMAT0001631 miRNA BIRC5 apoptosis down Homo sapiens lung cell 25026294 9606 332 API4|EPR-1 HGNC:593|MIM:603352|Ensembl:ENSG00000089685|HPRD:04520|Vega:OTTHUMG00000177505 17 17q25 baculoviral IAP repeat containing 5 protein-coding baculoviral IAP repeat containing 5 Gain - and loss - of - function assays indicated that re-expression of miR-451 could reverse radioresistance of docetaxel-resistant LAD cells both in vitro and in vivo through promoting apoptosis and DNA double-strand breaks (DSBs). The proto-oncogene c-Myc was identified as a direct target of miR-451, and re-expression of miR-451 inhibited survivin and rad-51 expression by reducing the amount of c-Myc protein binding to their promoters. 1890 miR-451 hsa-miR-451a,hsa-miR-451b MIMAT0001631,MIMAT0019840 miRNA CAB39 apoptosis down Homo sapiens 23886157 9606 51719 MO25 HGNC:20292|MIM:612174|Ensembl:ENSG00000135932|HPRD:10091|Vega:OTTHUMG00000133220 2 2q37.1 calcium binding protein 39 protein-coding calcium binding protein 39 In comparison to the controls, a significant increase in the expression of miR-451 was associated with significantly decreased expression of CAB39, LKB1, AMPK, AKT, PI3K and Bcl2. 1891 miR-451 hsa-miR-451a,hsa-miR-451b MIMAT0019840,MIMAT0001631 miRNA CASP3 apoptosis Homo sapiens hepatoma cell 24841638 9606 836 CPP32|CPP32B|SCA-1 HGNC:1504|MIM:600636|Ensembl:ENSG00000164305|HPRD:02799|Vega:OTTHUMG00000133681 4 4q34 caspase 3, apoptosis-related cysteine peptidase protein-coding caspase 3, apoptosis-related cysteine peptidase Further mechanistic analysis suggested that miR-451 overexpression accelerated cell death in a caspase-3-dependent manner, as pretreatment with its inhibitor z-VAD-fmk notably attenuated miR-451-induced cell apoptotic rates. Moreover, miR-451 upregulation abrogated cell invasive ability, accompanied with the decrease of matrix metalloproteinase-9 (MMP-9) expression levels, which may contribute to miR-451-triggered cell apoptosis. 1892 miR-451 hsa-miR-451a,hsa-miR-451b MIMAT0001631,MIMAT0019840 miRNA CCND1 apoptosis down Homo sapiens glioma cell 20816946 9606 595 BCL1|D11S287E|PRAD1|U21B31 HGNC:1582|MIM:168461|Ensembl:ENSG00000110092|HPRD:01346|Vega:OTTHUMG00000167877 11 11q13 cyclin D1 protein-coding cyclin D1 Akt1, CyclinD1, MMP-2, MMP-9 and Bcl-2 protein expression decreased, and p27 expression increased in a dose-dependent manner with miR-451 mimics oligonucleotides. Taken together, these studies reveal miR-451 impacts glioblastoma cell proliferation, invasion and apoptosis, perhaps via regulation of the PI3K/AKT signaling pathway. 1893 miR-451 hsa-miR-451a,hsa-miR-451b MIMAT0001631,MIMAT0019840 miRNA CCND1 apoptosis down Homo sapiens embryonic stem cell 24218283 9606 595 BCL1|D11S287E|PRAD1|U21B31 HGNC:1582|MIM:168461|Ensembl:ENSG00000110092|HPRD:01346|Vega:OTTHUMG00000167877 11 11q13 cyclin D1 protein-coding cyclin D1 Overexpression of miR-451 inhibited cell proliferation and resulted in cell apoptosis in osteosarcoma cells. G1 cell cycle arrest was also induced by miR-451. Repressed by miR-451, PGE2 and CCND1 reversed the inhibitory effects of miR-451 on proliferation. In conclusion, miR-451 played a tumor-suppressing role through modulating the expression of PGE2 and CCND1, suggesting a novel target for the diagnosis and treatment of osteosarcoma. 1894 miR-451 hsa-miR-451a,hsa-miR-451b MIMAT0019840,MIMAT0001631 miRNA CDH1 apoptosis down Homo sapiens bladder cancer cell 25550801 9606 999 Arc-1|CD324|CDHE|ECAD|LCAM|UVO HGNC:1748|MIM:192090|Ensembl:ENSG00000039068|HPRD:01885|Vega:OTTHUMG00000137561 16 16q22.1 cadherin 1, type 1, E-cadherin (epithelial) protein-coding cadherin 1, type 1, E-cadherin (epithelial) Results indicated over-expression of miR-451 significantly inhibited cell proliferation, migration, invasion and induced apoptosis of the bladder cancer cells. Furthermore, we investigated the expression level of EMT related proteins in transfected 5637 cells by western blot. Results shown E-cadherin was up-regulated more significantly than N-cadherin, vimentin and Snail. N-cadherin and vimentin were up-regulated significantly when miR-451 was inhibited in miR-451 inhibitor group, however, no significant changes in mimics group. 1895 miR-451 hsa-miR-451a,hsa-miR-451b MIMAT0019840,MIMAT0001631 miRNA CDH2 apoptosis down Homo sapiens bladder cancer cell 25550801 9606 1000 CD325|CDHN|CDw325|NCAD HGNC:1759|MIM:114020|Ensembl:ENSG00000170558|HPRD:00226|Vega:OTTHUMG00000059940 18 18q11.2 cadherin 2, type 1, N-cadherin (neuronal) protein-coding cadherin 2, type 1, N-cadherin (neuronal) Results indicated over-expression of miR-451 significantly inhibited cell proliferation, migration, invasion and induced apoptosis of the bladder cancer cells. Furthermore, we investigated the expression level of EMT related proteins in transfected 5637 cells by western blot. Results shown E-cadherin was up-regulated more significantly than N-cadherin, vimentin and Snail. N-cadherin and vimentin were up-regulated significantly when miR-451 was inhibited in miR-451 inhibitor group, however, no significant changes in mimics group. 1896 miR-451 hsa-miR-451a,hsa-miR-451b MIMAT0001631,MIMAT0019840 miRNA MMP2 apoptosis down Homo sapiens glioma cell 20816946 9606 4313 CLG4|CLG4A|MMP-II|MONA|TBE-1 HGNC:7166|MIM:120360|Ensembl:ENSG00000087245|HPRD:00386|Vega:OTTHUMG00000133202 16 16q13-q21 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) protein-coding matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) Akt1, CyclinD1, MMP-2, MMP-9 and Bcl-2 protein expression decreased, and p27 expression increased in a dose-dependent manner with miR-451 mimics oligonucleotides. Taken together, these studies reveal miR-451 impacts glioblastoma cell proliferation, invasion and apoptosis, perhaps via regulation of the PI3K/AKT signaling pathway. 1897 miR-451 hsa-miR-451a,hsa-miR-451b MIMAT0001631,MIMAT0019840 miRNA MMP9 apoptosis down Homo sapiens glioma cell 20816946 9606 4318 CLG4B|GELB|MANDP2|MMP-9 HGNC:7176|MIM:120361|Ensembl:ENSG00000100985|HPRD:00387|Vega:OTTHUMG00000033044 20 20q11.2-q13.1 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) protein-coding matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) Akt1, CyclinD1, MMP-2, MMP-9 and Bcl-2 protein expression decreased, and p27 expression increased in a dose-dependent manner with miR-451 mimics oligonucleotides. Taken together, these studies reveal miR-451 impacts glioblastoma cell proliferation, invasion and apoptosis, perhaps via regulation of the PI3K/AKT signaling pathway. 1898 miR-451 hsa-miR-451a,hsa-miR-451b MIMAT0001631,MIMAT0019840 miRNA MMP9 apoptosis down Homo sapiens hepatoma cell 24841638 9606 4318 CLG4B|GELB|MANDP2|MMP-9 HGNC:7176|MIM:120361|Ensembl:ENSG00000100985|HPRD:00387|Vega:OTTHUMG00000033044 20 20q11.2-q13.1 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) protein-coding matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) Further mechanistic analysis suggested that miR-451 overexpression accelerated cell death in a caspase-3-dependent manner, as pretreatment with its inhibitor z-VAD-fmk notably attenuated miR-451-induced cell apoptotic rates. Moreover, miR-451 upregulation abrogated cell invasive ability, accompanied with the decrease of matrix metalloproteinase-9 (MMP-9) expression levels, which may contribute to miR-451-triggered cell apoptosis. 1899 miR-451 hsa-miR-451a,hsa-miR-451b MIMAT0001631,MIMAT0019840 miRNA MYC apoptosis Homo sapiens lung cell 25026294 9606 4609 MRTL|MYCC|bHLHe39|c-Myc HGNC:7553|MIM:190080|Ensembl:ENSG00000136997|HPRD:01818|Vega:OTTHUMG00000128475 8 8q24.21 v-myc avian myelocytomatosis viral oncogene homolog protein-coding v-myc avian myelocytomatosis viral oncogene homolog Gain - and loss - of - function assays indicated that re-expression of miR-451 could reverse radioresistance of docetaxel-resistant LAD cells both in vitro and in vivo through promoting apoptosis and DNA double-strand breaks (DSBs). The proto-oncogene c-Myc was identified as a direct target of miR-451, and re-expression of miR-451 inhibited survivin and rad-51 expression by reducing the amount of c-Myc protein binding to their promoters. 1900 miR-451 hsa-miR-451a,hsa-miR-451b MIMAT0001631,MIMAT0019840 miRNA PIK3CA apoptosis down Homo sapiens 23886157 9606 5290 CLOVE|CWS5|MCAP|MCM|MCMTC|PI3K|p110-alpha HGNC:8975|MIM:171834|HPRD:01382 3 3q26.3 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha protein-coding phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha In comparison to the controls, a significant increase in the expression of miR-451 was associated with significantly decreased expression of CAB39, LKB1, AMPK, AKT, PI3K and Bcl2. 1901 miR-451 hsa-miR-451a,hsa-miR-451b MIMAT0001631,MIMAT0019840 miRNA PRKAA1 apoptosis down Homo sapiens 23886157 9606 5562 AMPK|AMPKa1 HGNC:9376|MIM:602739|Ensembl:ENSG00000132356|HPRD:04115|Vega:OTTHUMG00000162269 5 5p12 protein kinase, AMP-activated, alpha 1 catalytic subunit protein-coding protein kinase, AMP-activated, alpha 1 catalytic subunit In comparison to the controls, a significant increase in the expression of miR-451 was associated with significantly decreased expression of CAB39, LKB1, AMPK, AKT, PI3K and Bcl2. 1902 miR-451 hsa-miR-451a,hsa-miR-451b MIMAT0001631,MIMAT0019840 miRNA PTGER2 apoptosis down Homo sapiens embryonic stem cell 24218283 9606 5732 EP2 HGNC:9594|MIM:176804|Ensembl:ENSG00000125384|HPRD:08905|Vega:OTTHUMG00000140300 14 14q22 prostaglandin E receptor 2 (subtype EP2), 53kDa protein-coding prostaglandin E receptor 2 (subtype EP2), 53kDa Overexpression of miR-451 inhibited cell proliferation and resulted in cell apoptosis in osteosarcoma cells. G1 cell cycle arrest was also induced by miR-451. Repressed by miR-451, PGE2 and CCND1 reversed the inhibitory effects of miR-451 on proliferation. In conclusion, miR-451 played a tumor-suppressing role through modulating the expression of PGE2 and CCND1, suggesting a novel target for the diagnosis and treatment of osteosarcoma. 1903 miR-451 hsa-miR-451a,hsa-miR-451b MIMAT0001631,MIMAT0019840 miRNA RAB14 apoptosis down Homo sapiens nasopharyngeal carcinoma?cell 25201065 9606 51552 FBP|RAB-14 HGNC:16524|MIM:612673|Ensembl:ENSG00000119396|HPRD:06693|Vega:OTTHUMG00000020582 9 9q32-q34.11 RAB14, member RAS oncogene family protein-coding RAB14, member RAS oncogene family High levels of miR-451 expression enhanced radiosensitivity in NPC cells by inhibiting the repair of irradiation-induced double-strand breaks (DSBs) and increasing apoptosis. The results also demonstrated that miR-451 directly targeted ras-related protein 14 (RAB14). Downregulation of RAB14 partially replicated the miR-451-mediated DSBs induced by ionizing radiation (IR). MiR-451 could be a potential target for enhancing radiosensitivity of NPC cells by targeting RAB14. 1904 miR-451 hsa-miR-451a,hsa-miR-451b MIMAT0019840,MIMAT0001631 miRNA RAD51 apoptosis down Homo sapiens lung cell 25026294 9606 5888 BRCC5|HRAD51|HsRad51|HsT16930|MRMV2|RAD51A|RECA HGNC:9817|MIM:179617|Ensembl:ENSG00000051180|HPRD:01557|Vega:OTTHUMG00000130067 15 15q15.1 RAD51 recombinase protein-coding RAD51 recombinase Gain - and loss - of - function assays indicated that re-expression of miR-451 could reverse radioresistance of docetaxel-resistant LAD cells both in vitro and in vivo through promoting apoptosis and DNA double-strand breaks (DSBs). The proto-oncogene c-Myc was identified as a direct target of miR-451, and re-expression of miR-451 inhibited survivin and rad-51 expression by reducing the amount of c-Myc protein binding to their promoters. 1905 miR-451 hsa-miR-451a,hsa-miR-451b MIMAT0019840,MIMAT0001631 miRNA SNAI1 apoptosis down Homo sapiens bladder cancer cell 25550801 9606 6615 SLUGH2|SNA|SNAH|SNAIL|SNAIL1|dJ710H13.1 HGNC:11128|MIM:604238|Ensembl:ENSG00000124216|HPRD:05025|Vega:OTTHUMG00000033048 20 20q13.2 snail family zinc finger 1 protein-coding snail family zinc finger 1 Results indicated over-expression of miR-451 significantly inhibited cell proliferation, migration, invasion and induced apoptosis of the bladder cancer cells. Furthermore, we investigated the expression level of EMT related proteins in transfected 5637 cells by western blot. Results shown E-cadherin was up-regulated more significantly than N-cadherin, vimentin and Snail. N-cadherin and vimentin were up-regulated significantly when miR-451 was inhibited in miR-451 inhibitor group, however, no significant changes in mimics group. 1906 miR-451 hsa-miR-451a,hsa-miR-451b MIMAT0001631,MIMAT0019840 miRNA STK11 apoptosis down Homo sapiens 23886157 9606 6794 LKB1|PJS|hLKB1 HGNC:11389|MIM:602216|Ensembl:ENSG00000118046|HPRD:03740|Vega:OTTHUMG00000180118 19 19p13.3 serine/threonine kinase 11 protein-coding serine/threonine kinase 11 In comparison to the controls, a significant increase in the expression of miR-451 was associated with significantly decreased expression of CAB39, LKB1, AMPK, AKT, PI3K and Bcl2. 1907 miR-451 hsa-miR-451a,hsa-miR-451b MIMAT0019840,MIMAT0001631 miRNA VIM apoptosis down Homo sapiens bladder cancer cell 25550801 9606 7431 CTRCT30|HEL113 HGNC:12692|MIM:193060|Ensembl:ENSG00000026025|HPRD:01899|Vega:OTTHUMG00000017744 10 10p13 vimentin protein-coding vimentin Results indicated over-expression of miR-451 significantly inhibited cell proliferation, migration, invasion and induced apoptosis of the bladder cancer cells. Furthermore, we investigated the expression level of EMT related proteins in transfected 5637 cells by western blot. Results shown E-cadherin was up-regulated more significantly than N-cadherin, vimentin and Snail. N-cadherin and vimentin were up-regulated significantly when miR-451 was inhibited in miR-451 inhibitor group, however, no significant changes in mimics group. 1908 miR-451 hsa-miR-451a,hsa-miR-451b MIMAT0001631,MIMAT0019840 miRNA apoptosis Homo sapiens osteosarcoma 25471786 9606 After miR-451 transfection, cell proliferation, migration, and tumorigenesis in the osteosarcoma cells were significantly inhibited and cell apoptosis was increased. These findings indicate that miR-451 may act not only as a novel diagnostic and prognostic marker, but also as a potential target for molecular therapy of osteosarcoma. 1909 miR-451 hsa-miR-451a,hsa-miR-451b MIMAT0001631,MIMAT0019840 miRNA apoptosis down Homo sapiens bladder cancer cell 25550801 9606 Results indicated over-expression of miR-451 significantly inhibited cell proliferation, migration, invasion and induced apoptosis of the bladder cancer cells. Furthermore, we investigated the expression level of EMT related proteins in transfected 5637 cells by western blot. Results shown E-cadherin was up-regulated more significantly than N-cadherin, vimentin and Snail. N-cadherin and vimentin were up-regulated significantly when miR-451 was inhibited in miR-451 inhibitor group, however, no significant changes in mimics group. 1910 miR-451 hsa-miR-451a,hsa-miR-451b MIMAT0019840,MIMAT0001631 miRNA EPO apoptosis Homo sapiens Neuron-Like cell 25324845 9606 2056 EP|MVCD2 HGNC:3415|MIM:133170|Ensembl:ENSG00000130427|HPRD:00586|Vega:OTTHUMG00000152121 7 7q22 erythropoietin protein-coding erythropoietin Accordingly, target prediction and transcriptome analysis of cells treated with EPO revealed an alteration of the expression of genes involved in apoptosis, cell survival, proliferation, and migration.In this study, we report for the first time that EPO downregulates the expression of miRNAs (miR-451 and miR-885-5p) in SH-SY5Y neuronal-like cells. The correlation between the over-expression of miRNAs and the decrease in EPO-mediated biological effects suggests that miR-451 and miR-885-5p may play a key role in the mediation of biological function. 1911 miR-4516 hsa-miR-4516 MIMAT0019053 miRNA CDK6 apoptosis down Homo sapiens keratinocyte 24610393 9606 1021 PLSTIRE HGNC:1777|MIM:603368|Ensembl:ENSG00000105810|HPRD:04533|Vega:OTTHUMG00000131697 7 7q21-q22 cyclin-dependent kinase 6 protein-coding cyclin-dependent kinase 6 Hsa-miR-4516 mediated downregulation of STAT3/CDK6/UBE2N plays a role in PUVA induced apoptosis in keratinocytes. 1912 miR-4516 hsa-miR-4516 MIMAT0019053 miRNA STAT3 apoptosis down Homo sapiens keratinocyte 24610393 9606 6774 APRF|HIES HGNC:11364|MIM:102582|Ensembl:ENSG00000168610|HPRD:00026|Vega:OTTHUMG00000150645 17 17q21.31 signal transducer and activator of transcription 3 (acute-phase response factor) protein-coding signal transducer and activator of transcription 3 (acute-phase response factor) Hsa-miR-4516 mediated downregulation of STAT3/CDK6/UBE2N plays a role in PUVA induced apoptosis in keratinocytes. 1913 miR-4516 hsa-miR-4516 MIMAT0019053 miRNA UBE2N apoptosis down Homo sapiens keratinocyte 24610393 9606 7334 HEL-S-71|UBC13|UbcH-ben|UbcH13 HGNC:12492|MIM:603679|HPRD:04725 12 12q22 ubiquitin-conjugating enzyme E2N protein-coding ubiquitin-conjugating enzyme E2N Hsa-miR-4516 mediated downregulation of STAT3/CDK6/UBE2N plays a role in PUVA induced apoptosis in keratinocytes. 1914 miR-451a hsa-miR-451a MIMAT0001631 miRNA apoptosis Homo sapiens renal cell 25405789 9606 MicroRNA-451a is associated with cell proliferation, migration and apoptosis in renal cell carcinoma. 1915 miR-452 hsa-miR-452-5p,hsa-miR-452-3p MIMAT0001635,MIMAT0001636 miRNA CDKN1B apoptosis down Homo sapiens hepatocellular carcinoma cell 24381057 9606 1027 CDKN4|KIP1|MEN1B|MEN4|P27KIP1 HGNC:1785|MIM:600778|Ensembl:ENSG00000111276|HPRD:02867|Vega:OTTHUMG00000149914 12 12p13.1-p12 cyclin-dependent kinase inhibitor 1B (p27, Kip1) protein-coding cyclin-dependent kinase inhibitor 1B (p27, Kip1) We also found that overexpression of miR-452 dramatically accelerated proliferation, induced cell cycle from G1 to S transition, and blocked apoptosis of HCC cells. Migration and matrigel invasion assays indicated that miR-452 significantly promotes HepG2 and QGY-7703 cells migration and invasion in vitro. Further studies showed that miR-452 directly targets the 3'-untranslated region of cyclin-dependent kinase inhibitor 1B (CDKN1B), ectopic miR-452 expression suppressed CDKN1B expression on mRNA and protein level. Silencing CDKN1B by small interfering RNA resembled the phenotype resulting from ectopic miR-452 expression. This study provides new insights into the potential molecular mechanisms that miRNA-452 contributed to HCC. 1916 miR-455 hsa-miR-455-5p,hsa-miR-455-3p MIMAT0003150,MIMAT0004784 miRNA CALR apoptosis Homo sapiens cardiac cell 25695617 9606 811 CRT|HEL-S-99n|RO|SSA|cC1qR HGNC:1455|MIM:109091|Ensembl:ENSG00000179218|HPRD:00169|Vega:OTTHUMG00000180574 19 19p13.3-p13.2 calreticulin protein-coding calreticulin However, miR-455 replacement therapy markedly reduced myocardial fibrosis and inhibited apoptosis, suggesting that this therapy can prevent maladaptive ventricular remodeling. miR-455 was also identified and validated to target calreticulin, a protein that is critical for cardiac development. The restoration of miR-455 gene expression may thus be a potential therapeutic strategy to reverse pressure-induced cardiac hypertrophy and prevent maladaptive cardiac remodeling through the regulation of miR-455 at different time points following hypertrophy. 1917 miR-4802-3p hsa-miR-4802-3p MIMAT0019982 miRNA IL1A apoptosis Homo sapiens 25462332 9606 3552 IL-1A|IL1|IL1-ALPHA|IL1F1 HGNC:5991|MIM:147760|HPRD:00988 2 2q14 interleukin 1, alpha protein-coding interleukin 1, alpha Besides, miR-4802-3p targets three other apoptosis related genes, XIAP, IL1A and SOX2. This means that miR-4802-3p may also have a critical effect on apoptosis via different pathways other than caspase-3. We can therefore conclude that this is the first study proving a strong association between miR-4802-3p and apoptosis upon computational targetting analysis. 1918 miR-4802-3p hsa-miR-4802-3p MIMAT0019982 miRNA SOX2 apoptosis Homo sapiens 25462332 9606 6657 ANOP3|MCOPS3 HGNC:11195|MIM:184429|Ensembl:ENSG00000181449|HPRD:08921|Vega:OTTHUMG00000158222 3 3q26.3-q27 SRY (sex determining region Y)-box 2 protein-coding SRY (sex determining region Y)-box 2 Besides, miR-4802-3p targets three other apoptosis related genes, XIAP, IL1A and SOX2. This means that miR-4802-3p may also have a critical effect on apoptosis via different pathways other than caspase-3. We can therefore conclude that this is the first study proving a strong association between miR-4802-3p and apoptosis upon computational targetting analysis. 1919 miR-4802-3p hsa-miR-4802-3p MIMAT0019982 miRNA XIAP apoptosis Homo sapiens 25462332 9606 331 API3|BIRC4|IAP-3|ILP1|MIHA|XLP2|hIAP-3|hIAP3 HGNC:592|MIM:300079|Ensembl:ENSG00000101966|HPRD:02094|Vega:OTTHUMG00000022336 X Xq25 X-linked inhibitor of apoptosis protein-coding X-linked inhibitor of apoptosis Besides, miR-4802-3p targets three other apoptosis related genes, XIAP, IL1A and SOX2. This means that miR-4802-3p may also have a critical effect on apoptosis via different pathways other than caspase-3. We can therefore conclude that this is the first study proving a strong association between miR-4802-3p and apoptosis upon computational targetting analysis. 1920 miR-483-3p hsa-miR-483-3p MIMAT0002173 miRNA API5 apoptosis down Homo sapiens squamous cell carcinoma 24067364 9606 8539 AAC-11|AAC11 HGNC:594|MIM:609774|Ensembl:ENSG00000166181|HPRD:16500|Vega:OTTHUMG00000166395 11 11p11.2 apoptosis inhibitor 5 protein-coding apoptosis inhibitor 5 MiR-483-3p sensitized SCC cells to serum deprivation- and drug-induced apoptosis, thus exerting potent tumor suppressor activities. Its pro-apoptotic activity was mediated by a direct targeting of several anti-apoptotic genes, such as API5, BIRC5, and RAN. 1921 miR-483-3p hsa-miR-483-3p MIMAT0002173 miRNA BBC3 apoptosis down Homo sapiens colorectal cells 20388800 9606 27113 JFY-1|JFY1|PUMA HGNC:17868|MIM:605854|Ensembl:ENSG00000105327|HPRD:16165|Vega:OTTHUMG00000183489 19 19q13.3-q13.4 BCL2 binding component 3 protein-coding BCL2 binding component 3 bcl-2-binding component 3 MiR 483-3p could modulate the proapoptotic protein BBC3/PUMA and miR-483-3p enforced expression could protect cells from apoptosis. 1922 miR-483-3p hsa-miR-483-3p MIMAT0002173 miRNA BBC3 apoptosis down Homo sapiens adrenocortical carcinoma cells 21859927 9606 27113 JFY-1|JFY1|PUMA HGNC:17868|MIM:605854|Ensembl:ENSG00000105327|HPRD:16165|Vega:OTTHUMG00000183489 19 19q13.3-q13.4 BCL2 binding component 3 protein-coding BCL2 binding component 3 bcl-2-binding component 3 Protein expression of p53 upregulated modulator of apoptosis (PUMA), a potential target of miR-483-3p, was significantly decreased in ACC, and inversely correlated with miR-483-3p expression. 1923 miR-483-3p hsa-miR-483-3p MIMAT0002173 miRNA BIRC5 apoptosis down Homo sapiens squamous cell carcinoma 24067364 9606 332 API4|EPR-1 HGNC:593|MIM:603352|Ensembl:ENSG00000089685|HPRD:04520|Vega:OTTHUMG00000177505 17 17q25 baculoviral IAP repeat containing 5 protein-coding baculoviral IAP repeat containing 5 MiR-483-3p sensitized SCC cells to serum deprivation- and drug-induced apoptosis, thus exerting potent tumor suppressor activities. Its pro-apoptotic activity was mediated by a direct targeting of several anti-apoptotic genes, such as API5, BIRC5, and RAN. 1924 miR-483-3p hsa-miR-483-3p MIMAT0002173 miRNA RAN apoptosis down Homo sapiens squamous cell carcinoma 24067364 9606 5901 ARA24|Gsp1|TC4 HGNC:9846|MIM:601179|HPRD:03109 12 12q24.3 RAN, member RAS oncogene family protein-coding RAN, member RAS oncogene family MiR-483-3p sensitized SCC cells to serum deprivation- and drug-induced apoptosis, thus exerting potent tumor suppressor activities. Its pro-apoptotic activity was mediated by a direct targeting of several anti-apoptotic genes, such as API5, BIRC5, and RAN. 1925 miR-486 hsa-miR-486-5p,hsa-miR-486-3p MIMAT0002177,MIMAT0004762 miRNA DOCK3 apoptosis down Homo sapiens skeletal muscle 24789910 9606 1795 MOCA|PBP HGNC:2989|MIM:603123|Ensembl:ENSG00000088538|HPRD:10341|Vega:OTTHUMG00000156892 3 3p21.2 dedicator of cytokinesis 3 protein-coding dedicator of cytokinesis 3 DOCK3 overexpression in human myotubes modulated PTEN/AKT signaling, which regulates muscle hypertrophy and growth, and induced apoptosis. Furthermore, several components of the PTEN/AKT pathway were markedly modulated by miR-486 in dystrophin-deficient muscle. Skeletal muscle-specific miR-486 overexpression in Dmdmdx-5Cv animals decreased levels of DOCK3, reduced PTEN expression, and subsequently increased levels of phosphorylated AKT, which resulted in an overall beneficial effect. 1926 miR-486-5p hsa-miR-486-5p MIMAT0002177 miRNA PIM1 apoptosis down Homo sapiens breast cancer cell 25104088 9606 5292 PIM HGNC:8986|MIM:164960|Ensembl:ENSG00000137193|HPRD:01292|Vega:OTTHUMG00000016426 6 6p21.2 Pim-1 proto-oncogene, serine/threonine kinase protein-coding Pim-1 proto-oncogene, serine/threonine kinase Overexpression of miR-486-5p dramatically suppressed BC cell proliferation in vitro and in vivo, induced G0/G1 arrest, and promoted apoptosis. We subsequently identified the oncogene PIM-1 as a direct target of miR-486-5p in BC. Overexpression of PIM-1 attenuated the function of miR-486-5p in BC cells. Together, we conclude that miR-486-5p exerts its antiproliferative function by directly downregulating PIM-1 expression. 1927 miR-489 hsa-miR-489-5p,hsa-miR-489-3p MIMAT0026605,MIMAT0002805 miRNA AKT3 apoptosis down Homo sapiens ovaries cell 24686007 9606 10000 MPPH|PKB-GAMMA|PKBG|PRKBG|RAC-PK-gamma|RAC-gamma|STK-2 HGNC:393|MIM:611223|Ensembl:ENSG00000117020|HPRD:06441|Vega:OTTHUMG00000039994 1 1q44 v-akt murine thymoma viral oncogene homolog 3 protein-coding v-akt murine thymoma viral oncogene homolog 3 MiR-489 overexpression results in an inhibition of SKOV3 and OVCAR3 cell survival and cell growth after CDDP treatment and an induction of cell apoptosis. Inhibition of miR-489 yields the opposite results. In addition, miR-489 overexpression increases the sensitivity of SKOV3/CDDP and OVCAR3/CDDP cells to CDDP and inhibits their colony number. Akt3 is validated as a direct target of miR-489 in SKOV3, OVCAR3, SKOV3/CDDP and OVCAR3/CDDP cells. In addition, miR-489 suppresses Akt3 protein expression by binding sites on its 3'UTR. Knockdown of Akt3 results in a similar effect as that because of miR-489 overexpression; importantly, Akt3 silencing rescues the functions induced by miR-489. 1928 miR-489 hsa-miR-489-5p,hsa-miR-489-3p MIMAT0026605,MIMAT0002805 miRNA CHRF apoptosis down Homo sapiens cardiac 24557880 9606 lncRNA In the animal model, enforced expression of CHRF increased the apoptosis of cardiomyocytes.CHRF is able to directly bind to miR-489 and regulate Myd88 expression and hypertrophy. 1929 miR-491 hsa-miR-491-5p,hsa-miR-491-3p MIMAT0002807,MIMAT0004765 miRNA BCL2L1 apoptosis down Homo sapiens colorectal cancer cells 20039318 9606 598 BCL-XL/S|BCL2L|BCLX|BCLXL|BCLXS|Bcl-X|PPP1R52|bcl-xL|bcl-xS HGNC:992|MIM:600039|Ensembl:ENSG00000171552|HPRD:02497|Vega:OTTHUMG00000032192 20 20q11.21 BCL2-like 1 protein-coding BCL2-like 1 apoptosis regulator Bcl-X Bcl-X(L) was a direct target of miR-491, and its silencing contributed to miR-491-induced apoptosis. 1930 miR-491-5p hsa-miR-491-5p MIMAT0002807 miRNA AFP apoptosis down Homo sapiens Hep G2 cell 20015148 9606 174 FETA|HPAFP HGNC:317|MIM:104150|Ensembl:ENSG00000081051|HPRD:00074|Vega:OTTHUMG00000130011 4 4q13.3 alpha-fetoprotein protein-coding alpha-fetoprotein Upregulation of miRNA-491-5p was found in a high-dose anti-fas receptor antibody group. Overexpression of microRNA-491_5p sensitized Hep G2 cells for TNF-alpha-induced apoptosis, and also caused an inhibition of alpha-fetoprotein, (AFP), heat shock protein-90 (hsp-90) and nuclear factor-kappaB (NF-kappaB). Overexpression of miRNA-491_5p or inhibition of AFP and hsp-90 resulted in an increased apoptosis in TNF-alpha-treated Hep G2 cells. 1931 miR-491-5p hsa-miR-491-5p MIMAT0002807 miRNA BCL2L1 apoptosis down Homo sapiens pancreatic cancer cell line SW1990 23519249 9606 598 BCL-XL/S|BCL2L|BCLX|BCLXL|BCLXS|Bcl-X|PPP1R52|bcl-xL|bcl-xS HGNC:992|MIM:600039|Ensembl:ENSG00000171552|HPRD:02497|Vega:OTTHUMG00000032192 20 20q11.21 BCL2-like 1 protein-coding BCL2-like 1 Overexpression of miR-491-5p in the pancreatic cancer cell line SW1990 effectively inhibited both endogenous Bcl-XL and TP53 gene expressions. 1932 miR-491-5p hsa-miR-491-5p MIMAT0002807 miRNA BCL2L1 apoptosis down Homo sapiens ovarian cancer cell 25299770 9606 598 BCL-XL/S|BCL2L|BCLX|BCLXL|BCLXS|Bcl-X|PPP1R52|bcl-xL|bcl-xS HGNC:992|MIM:600039|Ensembl:ENSG00000171552|HPRD:02497|Vega:OTTHUMG00000032192 20 20q11.21 BCL2-like 1 protein-coding BCL2-like 1 MiR-491-5p-induced apoptosis in ovarian carcinoma depends on the direct inhibition of both BCL-XL and EGFR leading to BIM activation. 1933 miR-491-5p hsa-miR-491-5p MIMAT0002807 miRNA BCL2L11 apoptosis up Homo sapiens ovarian cancer cell 25299770 9606 10018 BAM|BIM|BOD HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 2 2q13 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) MiR-491-5p-induced apoptosis in ovarian carcinoma depends on the direct inhibition of both BCL-XL and EGFR leading to BIM activation. 1934 miR-491-5p hsa-miR-491-5p MIMAT0002807 miRNA EGFR apoptosis down Homo sapiens ovarian cancer cell 25299770 9606 1956 ERBB|ERBB1|HER1|PIG61|mENA HGNC:3236|MIM:131550|Ensembl:ENSG00000146648|HPRD:00579|Vega:OTTHUMG00000023661 7 7p12 epidermal growth factor receptor protein-coding epidermal growth factor receptor MiR-491-5p-induced apoptosis in ovarian carcinoma depends on the direct inhibition of both BCL-XL and EGFR leading to BIM activation. 1935 miR-491-5p hsa-miR-491-5p MIMAT0002807 miRNA HSP90AA1 apoptosis down Homo sapiens Hep G2 cell 20015148 9606 3320 EL52|HSP86|HSP89A|HSP90A|HSP90N|HSPC1|HSPCA|HSPCAL1|HSPCAL4|HSPN|Hsp89|Hsp90|LAP-2|LAP2 HGNC:5253|MIM:140571|Ensembl:ENSG00000080824|HPRD:00777|Vega:OTTHUMG00000171752 14 14q32.33 heat shock protein 90kDa alpha (cytosolic), class A member 1 protein-coding heat shock protein 90kDa alpha (cytosolic), class A member 1 Upregulation of miRNA-491-5p was found in a high-dose anti-fas receptor antibody group. Overexpression of microRNA-491_5p sensitized Hep G2 cells for TNF-alpha-induced apoptosis, and also caused an inhibition of alpha-fetoprotein, (AFP), heat shock protein-90 (hsp-90) and nuclear factor-kappaB (NF-kappaB). Overexpression of miRNA-491_5p or inhibition of AFP and hsp-90 resulted in an increased apoptosis in TNF-alpha-treated Hep G2 cells. 1936 miR-491-5p hsa-miR-491-5p MIMAT0002807 miRNA NFKB1 apoptosis down Homo sapiens Hep G2 cell 20015148 9606 4790 EBP-1|KBF1|NF-kB1|NF-kappa-B|NF-kappaB|NFKB-p105|NFKB-p50|NFkappaB|p105|p50 HGNC:7794|MIM:164011|Ensembl:ENSG00000109320|HPRD:01238|Vega:OTTHUMG00000161080 4 4q24 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 protein-coding nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Upregulation of miRNA-491-5p was found in a high-dose anti-fas receptor antibody group. Overexpression of microRNA-491_5p sensitized Hep G2 cells for TNF-alpha-induced apoptosis, and also caused an inhibition of alpha-fetoprotein, (AFP), heat shock protein-90 (hsp-90) and nuclear factor-kappaB (NF-kappaB). Overexpression of miRNA-491_5p or inhibition of AFP and hsp-90 resulted in an increased apoptosis in TNF-alpha-treated Hep G2 cells. 1937 miR-491-5p hsa-miR-491-5p MIMAT0002807 miRNA TP53 apoptosis down Homo sapiens pancreatic cancer cell line SW1990 23519249 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 Overexpression of miR-491-5p in the pancreatic cancer cell line SW1990 effectively inhibited both endogenous Bcl-XL and TP53 gene expressions. 1938 miR-494 hsa-miR-494-3p,hsa-miR-494-5p MIMAT0002816,MIMAT0026607 miRNA BAG1 apoptosis Homo sapiens gastric cancer cell 24606447 9606 573 BAG-1|HAP|RAP46 HGNC:937|MIM:601497|Ensembl:ENSG00000107262|HPRD:03292|Vega:OTTHUMG00000019766 9 9p12 BCL2-associated athanogene protein-coding BCL2-associated athanogene In summary, our study demonstrated that cinobufacin may inhibit the proliferation and promote the apoptosis of BGC-823 cells. Cinobufacin-associated miR-494 may indirectly be involved in cell proliferation and apoptosis by targeting BAG-1, pointing to use as a potential molecular target of cinobufacin in gastric cancer therapy. 1939 miR-494 hsa-miR-494-3p,hsa-miR-494-5p MIMAT0002816,MIMAT0026607 miRNA BCL2L11 apoptosis up Homo sapiens non-small-cell lung cancer cells 23012423 9606 10018 BAM|BIM|BOD HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 2 2q13 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) Moreover, we found that miR-494 induced Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) resistance in non-small-cell lung cancer (NSCLC) through the down-modulation of BIM. 1940 miR-494 hsa-miR-494-3p,hsa-miR-494-5p MIMAT0002816,MIMAT0026607 miRNA CLPTM1L apoptosis down Homo sapiens esophageal squamous cell 25480402 9606 81037 CRR9 HGNC:24308|MIM:612585|Ensembl:ENSG00000049656|HPRD:07480|Vega:OTTHUMG00000131015 5 5p15.33 CLPTM1-like protein-coding CLPTM1-like The qRT-PCR assays showed significant downregulation of miR-494 (P < 0.05) and upregulation of CLPTM1L mRNA (P < 0.05), both of which were significantly associated with lymph node metastases (P < 0.05). High expression of miR-494 inhibited cell proliferation and invasion and promoted cell apoptosis (P < 0.05). The results also showed that CLPTM1L was a target of miR-494. CONCLUSION:These results show that the expression of miR-494, which can regulate cell growth, invasion and apoptosis of ESCC cells by targeting CLPTM1L, is downregulated in ESCC tumor tissues. The miR-494-CLPTM1L pathway could be further exploited to develop a new approach to treat ESCC. 1941 miR-494 hsa-miR-494-5p,hsa-miR-494-3p MIMAT0026607,MIMAT0002816 miRNA HIF1A apoptosis up Homo sapiens L02 cell 24364919 9606 3091 HIF-1A|HIF-1alpha|HIF1|HIF1-ALPHA|MOP1|PASD8|bHLHe78 HGNC:4910|MIM:603348|Ensembl:ENSG00000100644|HPRD:04517|Vega:OTTHUMG00000140344 14 14q23.2 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) Overexpression of miR-494 upregulated HIF-1¦Á expression through activating PI3K/Akt pathway under both normoxia and hypoxia, and had protective effects against hypoxia-induced apoptosis in L02 cells. Thus, these findings suggested that miR-494 might be a target of therapy for hepatic hypoxia/ischemia injury. 1942 miR-494 hsa-miR-494-5p,hsa-miR-494-3p MIMAT0026607,MIMAT0002816 miRNA SCGN apoptosis Homo sapiens lung cancer cell 25226615 9606 10590 CALBL|DJ501N12.8|SECRET|SEGN|setagin HGNC:16941|MIM:609202|Ensembl:ENSG00000079689|HPRD:10211|Vega:OTTHUMG00000014409 6 6p22.3-p22.1 secretagogin, EF-hand calcium binding protein protein-coding secretagogin, EF-hand calcium binding protein We also found that knockdown of SCGN expression in H69AR and H446AR cells increased chemosensitivity via increasing cell apoptosis and cell cycle arrest of G0/G1 phase, while over-expression of SCGN reduced chemosensitivity in sensitive H69 and H446 cells. SCGN as a novel target of miR-494 by luciferase reporter assay, up-regulation of miR-494 can sensitize H69AR cells to chemotherapeutic drugs. These results suggest SCGN is involved in the chemoresistance of SCLC under the regulation of miR-494 and may be a potential biomarker for predicting therapeutic response in treatment SCLC. 1943 miR-494-3p hsa-miR-494-3p MIMAT0002816 miRNA AKT1 apoptosis up Homo sapiens gliomas 25662849 9606 207 AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA HGNC:391|MIM:164730|Ensembl:ENSG00000142208|HPRD:01261|Vega:OTTHUMG00000170795 14 14q32.32 v-akt murine thymoma viral oncogene homolog 1 protein-coding v-akt murine thymoma viral oncogene homolog 1 MiR-494-3p inhibitor could prevent migration, invasion, proliferation, and promote apotosis in gliomas through PTEN/AKT pathway 1944 miR-494-3p hsa-miR-494-3p MIMAT0002816 miRNA CXCR4 apoptosis down Homo sapiens prostate cancer cell 24644030 9606 7852 CD184|D2S201E|FB22|HM89|HSY3RR|LAP-3|LAP3|LCR1|LESTR|NPY3R|NPYR|NPYRL|NPYY3R|WHIM HGNC:2561|MIM:162643|Ensembl:ENSG00000121966|HPRD:01217|Vega:OTTHUMG00000153583 2 2q21 chemokine (C-X-C motif) receptor 4 protein-coding chemokine (C-X-C motif) receptor 4 MiR-494-3p also could bind to the seed sequences in the 3'-UTR of the CXCR4 gene. Artificial over-expression of miR-494-3p could inhibit the growth, promote the apoptosis, and inhibit the migration and invasion of PC-3 and DU145 cells in vivo. 1945 miR-494-3p hsa-miR-494-3p MIMAT0002816 miRNA PTEN apoptosis up Homo sapiens gliomas 25662849 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog MiR-494-3p inhibitor could prevent migration, invasion, proliferation, and promote apotosis in gliomas through PTEN/AKT pathway 1946 miR-495 hsa-miR-495-3p,hsa-miR-495-5p MIMAT0022924,MIMAT0002817 miRNA CASP3 apoptosis Homo sapiens umbilical vein endothelial cell 25466836 9606 836 CPP32|CPP32B|SCA-1 HGNC:1504|MIM:600636|Ensembl:ENSG00000164305|HPRD:02799|Vega:OTTHUMG00000133681 4 4q34 caspase 3, apoptosis-related cysteine peptidase protein-coding caspase 3, apoptosis-related cysteine peptidase MiR-495 was down-regulated in patients with coronary artery disease compared with healthy controls. CCL2 was a novel target gene of miR-495. MiR-495 significantly promoted HUVECs proliferation by altering cell cycle distribution, and it also inhibited HUVECs apoptosis by affecting the expression of cleaved caspase 3. Effects of miR-495 on HUVECs proliferation and apoptosis were significantly reversed by overexpression of CCL2. 1947 miR-495 hsa-miR-495-3p,hsa-miR-495-5p MIMAT0002817,MIMAT0022924 miRNA CCL2 apoptosis up Homo sapiens umbilical vein endothelial cell 25466836 9606 6347 GDCF-2|HC11|HSMCR30|MCAF|MCP-1|MCP1|SCYA2|SMC-CF HGNC:10618|MIM:158105|Ensembl:ENSG00000108691|HPRD:01149|Vega:OTTHUMG00000132887 17 17q11.2-q12 chemokine (C-C motif) ligand 2 protein-coding chemokine (C-C motif) ligand 2 MiR-495 was down-regulated in patients with coronary artery disease compared with healthy controls. CCL2 was a novel target gene of miR-495. MiR-495 significantly promoted HUVECs proliferation by altering cell cycle distribution, and it also inhibited HUVECs apoptosis by affecting the expression of cleaved caspase 3. Effects of miR-495 on HUVECs proliferation and apoptosis were significantly reversed by overexpression of CCL2. 1948 miR-495 hsa-miR-495-3p,hsa-miR-495-5p MIMAT0002817,MIMAT0022924 miRNA MEIS1 apoptosis up Homo sapiens leukemic cells 23132946 9606 4211 - HGNC:7000|MIM:601739|Ensembl:ENSG00000143995|HPRD:03442 2 2p14 Meis homeobox 1 protein-coding Meis homeobox 1 In human leukemic cells carrying MLL rearrangements, ectopic expression of miR-495 greatly inhibits cell viability and increases cell apoptosis. Furthermore, our studies demonstrate that PBX3 and MEIS1 are two direct target genes of miR-495, and forced expression of either of them can reverse the effects of miR-495 overexpression on inhibiting cell viability and promoting apoptosis of human MLL-rearranged leukemic cells. 1949 miR-495 hsa-miR-495-3p,hsa-miR-495-5p MIMAT0002817,MIMAT0022924 miRNA PBX3 apoptosis up Homo sapiens leukemic cells 23132946 9606 5090 - HGNC:8634|MIM:176312|Ensembl:ENSG00000167081|HPRD:15938|Vega:OTTHUMG00000020684 9 9q33.3 pre-B-cell leukemia homeobox 3 protein-coding pre-B-cell leukemia homeobox 3 In human leukemic cells carrying MLL rearrangements, ectopic expression of miR-495 greatly inhibits cell viability and increases cell apoptosis. Furthermore, our studies demonstrate that PBX3 and MEIS1 are two direct target genes of miR-495, and forced expression of either of them can reverse the effects of miR-495 overexpression on inhibiting cell viability and promoting apoptosis of human MLL-rearranged leukemic cells. 1950 miR-497 hsa-miR-497-5p,hsa-miR-497-3p MIMAT0004768,MIMAT0002820 miRNA AKT1 apoptosis down Homo sapiens pancreatic cancer cell 24667580 9606 207 AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA HGNC:391|MIM:164730|Ensembl:ENSG00000142208|HPRD:01261|Vega:OTTHUMG00000170795 14 14q32.32 v-akt murine thymoma viral oncogene homolog 1 protein-coding v-akt murine thymoma viral oncogene homolog 1 Upregulation of miR-497 in BxPC-3 and AsPC-1 pancreatic cancer cell lines inhibited proliferation, enhanced apoptosis, re-sensitized cells to gemcitabine and suppressed IGF-1R and p-AKT expression through direct downregulation of IGF-1R protein expression. 1951 miR-497 hsa-miR-497-5p,hsa-miR-497-3p MIMAT0002820,MIMAT0004768 miRNA BCL2 apoptosis up Homo sapiens gastric cancer cells 21258880 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 apoptosis regulator Bcl-2 Has-miR-497 could play a role in both gastric and lung cancer cell lines at least in part by modulation of apoptosis via targeting BCL2. 1952 miR-497 hsa-miR-497-5p,hsa-miR-497-3p MIMAT0004768,MIMAT0002820 miRNA BCL2 apoptosis down Homo sapiens SH-SY5Y cell 21878650 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Cotransfection studies with 3'-UTR of these genes and miRNA mimics have demonstrated that BCL2 is a direct target of miR-497 and that CCND2 is regulated negatively by either miR-302b or miR-497. Overexpression of either miR-497 or miR-302b reduced expression of their identified target genes and increased caspase 3-mediated apoptosis of SH-SY5Y cells. 1953 miR-497 hsa-miR-497-5p,hsa-miR-497-3p MIMAT0004768,MIMAT0002820 miRNA BCL2L2 apoptosis down Homo sapiens 22969914 9606 599 BCL-W|BCL2-L-2|BCLW|PPP1R51 HGNC:995|MIM:601931|Ensembl:ENSG00000129473|HPRD:03569|Vega:OTTHUMG00000028738 14 14q11.2-q12 BCL2-like 2 protein-coding BCL2-like 2 MiR-497 induces apoptosis of breast cancer cells by targeting Bcl-w.RT-PCR and Western blot analysis data indicated that the overexpression of miR-497 resulted in the down-regulation of Bcl-w at the mRNA and protein levels. 1954 miR-497 hsa-miR-497-5p,hsa-miR-497-3p MIMAT0002820,MIMAT0004768 miRNA CASP3 apoptosis up Homo sapiens prostate 23886135 9606 836 CPP32|CPP32B|SCA-1 HGNC:1504|MIM:600636|Ensembl:ENSG00000164305|HPRD:02799|Vega:OTTHUMG00000133681 4 4q34 caspase 3, apoptosis-related cysteine peptidase protein-coding caspase 3, apoptosis-related cysteine peptidase We also observed that miR-497 increased the percentage of apoptotic cells by increasing caspase-3/7 activity. 1955 miR-497 hsa-miR-497-5p,hsa-miR-497-3p MIMAT0004768,MIMAT0002820 miRNA CCND2 apoptosis down Homo sapiens SH-SY5Y cell 21878650 9606 894 KIAK0002 HGNC:1583|MIM:123833|Ensembl:ENSG00000118971|HPRD:00451|Vega:OTTHUMG00000168123 12 12p13 cyclin D2 protein-coding cyclin D2 Cotransfection studies with 3'-UTR of these genes and miRNA mimics have demonstrated that BCL2 is a direct target of miR-497 and that CCND2 is regulated negatively by either miR-302b or miR-497. Overexpression of either miR-497 or miR-302b reduced expression of their identified target genes and increased caspase 3-mediated apoptosis of SH-SY5Y cells. 1956 miR-497 hsa-miR-497-5p,hsa-miR-497-3p MIMAT0004768,MIMAT0002820 miRNA IGF1R apoptosis down Homo sapiens pancreatic cancer cell 24667580 9606 3480 CD221|IGFIR|IGFR|JTK13 HGNC:5465|MIM:147370|Ensembl:ENSG00000140443|HPRD:00932|Vega:OTTHUMG00000149851 15 15q26.3 insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor Upregulation of miR-497 in BxPC-3 and AsPC-1 pancreatic cancer cell lines inhibited proliferation, enhanced apoptosis, re-sensitized cells to gemcitabine and suppressed IGF-1R and p-AKT expression through direct downregulation of IGF-1R protein expression. 1957 miR-497 hsa-miR-497-5p,hsa-miR-497-3p MIMAT0002820,MIMAT0004768 miRNA PDCD4 apoptosis down Homo sapiens glioma cell 25080009 9606 27250 H731 HGNC:8763|MIM:608610|Ensembl:ENSG00000150593|HPRD:10549|Vega:OTTHUMG00000019048 10 10q24 programmed cell death 4 (neoplastic transformation inhibitor) protein-coding programmed cell death 4 (neoplastic transformation inhibitor) Ectopic overexpression of miR-497 promotes chemotherapy resistance in glioma cells by targeting PDCD4, a tumor suppressor that is involved in apoptosis. In contrast, the inhibition of miR-497 enhances apoptosis and increases the sensitivity of glioma cells to TMZ. These results suggest that miR-497 is a potential molecular target for glioma therapy. 1958 miR-497 hsa-miR-497-5p,hsa-miR-497-3p MIMAT0002820,MIMAT0004768 miRNA WEE1 apoptosis down Homo sapiens MYCN amplified neuroblastoma cell 23531080 9606 7465 WEE1A|WEE1hu HGNC:12761|MIM:193525|Ensembl:ENSG00000166483|HPRD:01907|Vega:OTTHUMG00000165863 11 11p15.4 WEE1 G2 checkpoint kinase protein-coding WEE1 G2 checkpoint kinase Our study's results are consistent with miR-497 being a candidate tumor suppressor in neuroblastoma, through the direct targeting of WEE1. These findings re-enforce the proposal of WEE1 as a therapeutic target in neuroblastoma. 1959 miR-499 hsa-miR-499a-5p£¬hsa-miR-499a-3p MIMAT0002870,MIMAT0004772 miRNA BID apoptosis down Homo sapiens cardiomyocytes 24646523 9606 637 FP497 HGNC:1050|MIM:601997|Ensembl:ENSG00000015475|HPRD:03590|Vega:OTTHUMG00000150087 22 22q11.1 BH3 interacting domain death agonist protein-coding BH3 interacting domain death agonist We report that cardiac-abundant miR-499 could protect neonatal rat cardiomyocytes against H 2O 2-induced apoptosis. Increased miR-499 level favored survival, while decreased miR-499 level favored apoptosis. We identified three proapoptotic protein-coding genes-Pdcd4, Pacs2, and Dyrk2-as targets of miR-499. miR-499 inhibited cardiomyocyte apoptosis through its suppressive effect on Pdcd4 and Pacs2 expression, thereby blocking Bid expression and BID mitochondrial translocation. 1960 miR-499 hsa-miR-499a-5p£¬hsa-miR-499a-3p MIMAT0002870,MIMAT0004772 miRNA DNM1L apoptosis down Homo sapiens 21186368 9606 10059 DLP1|DRP1|DVLP|DYMPLE|EMPF|HDYNIV HGNC:2973|MIM:603850|Ensembl:ENSG00000087470|HPRD:04833|Vega:OTTHUMG00000169451 12 12p11.21 dynamin 1-like protein-coding dynamin 1-like We found that both the ¦Á- and ¦Â-isoforms of the calcineurin catalytic subunit are direct targets of miR-499 and that miR-499 inhibits cardiomyocyte apoptosis through its suppression of calcineurin-mediated dephosphorylation of dynamin-related protein-1 (Drp1), thereby decreasing Drp1 accumulation in mitochondria and Drp1-mediated activation of the mitochondrial fission program. 1961 miR-499 hsa-miR-499a-5p£¬hsa-miR-499a-3p MIMAT0002870,MIMAT0004772 miRNA PACS2 apoptosis down Homo sapiens cardiomyocytes 24646523 9606 23241 PACS-2|PACS1L HGNC:23794|MIM:610423|Ensembl:ENSG00000179364|HPRD:17816|Vega:OTTHUMG00000170450 14 14q32.33 phosphofurin acidic cluster sorting protein 2 protein-coding phosphofurin acidic cluster sorting protein 2 We report that cardiac-abundant miR-499 could protect neonatal rat cardiomyocytes against H 2O 2-induced apoptosis. Increased miR-499 level favored survival, while decreased miR-499 level favored apoptosis. We identified three proapoptotic protein-coding genes-Pdcd4, Pacs2, and Dyrk2-as targets of miR-499. miR-499 inhibited cardiomyocyte apoptosis through its suppressive effect on Pdcd4 and Pacs2 expression, thereby blocking Bid expression and BID mitochondrial translocation. 1962 miR-499 hsa-miR-499a-5p£¬hsa-miR-499a-3p MIMAT0002870,MIMAT0004772 miRNA PDCD4 apoptosis down Homo sapiens cardiomyocytes 24646523 9606 27250 H731 HGNC:8763|MIM:608610|Ensembl:ENSG00000150593|HPRD:10549|Vega:OTTHUMG00000019048 10 10q24 programmed cell death 4 (neoplastic transformation inhibitor) protein-coding programmed cell death 4 (neoplastic transformation inhibitor) We report that cardiac-abundant miR-499 could protect neonatal rat cardiomyocytes against H 2O 2-induced apoptosis. Increased miR-499 level favored survival, while decreased miR-499 level favored apoptosis. We identified three proapoptotic protein-coding genes-Pdcd4, Pacs2, and Dyrk2-as targets of miR-499. miR-499 inhibited cardiomyocyte apoptosis through its suppressive effect on Pdcd4 and Pacs2 expression, thereby blocking Bid expression and BID mitochondrial translocation. 1963 miR-500 hsa-miR-500a-5p,hsa-miR-500a-3p,hsa-miR-500b-5p,hsa-miR-500b-3p MIMAT0004773,MIMAT0002871,MIMAT0016925,MIMAT0027032 miRNA CYLD apoptosis down Homo sapiens non-small cell lung cancer cell 25595906 9606 1540 BRSS|CDMT|CYLD1|CYLDI|EAC|MFT|MFT1|SBS|TEM|USPL2 HGNC:2584|MIM:605018|Ensembl:ENSG00000083799|HPRD:05427|Vega:OTTHUMG00000173404 16 16q12.1 cylindromatosis (turban tumor syndrome) protein-coding cylindromatosis (turban tumor syndrome) Here, we report that the miR-500 directly repressed the expression of CYLD, OTUD7B, and the A20 complex component Tax1-binding protein 1 (TAX1BP1), leading to ubiquitin conjugation of receptor-interacting protein 1 (RIP1) and sustained NF-??B activation. Furthermore, we found that miR-500 promoted gastric cancer cell proliferation, survival, and tumorigenicity. Importantly, miR-500 was upregulated in gastric cancer and was highly correlated with malignant progression and poor survival. Hence, we report the uncovering of a novel mechanism for constitutive NF-¦ÊB activation, indicating the potentially pivotal role of miR-500 in the progression of gastric cancer. 1964 miR-500 hsa-miR-500a-5p,hsa-miR-500a-3p,hsa-miR-500b-5p,hsa-miR-500b-3p MIMAT0004773,MIMAT0002871,MIMAT0016925,MIMAT0027032 miRNA NKILA apoptosis up Homo sapiens non-small cell lung cancer cell 25595906 9606 105416157 HGNC:51599 20 chromosome: 20 NF-kappaB interacting long non-coding RNA ncRNA NF-kappaB interacting long non-coding RNA Here, we report that the miR-500 directly repressed the expression of CYLD, OTUD7B, and the A20 complex component Tax1-binding protein 1 (TAX1BP1), leading to ubiquitin conjugation of receptor-interacting protein 1 (RIP1) and sustained NF-??B activation. Furthermore, we found that miR-500 promoted gastric cancer cell proliferation, survival, and tumorigenicity. Importantly, miR-500 was upregulated in gastric cancer and was highly correlated with malignant progression and poor survival. Hence, we report the uncovering of a novel mechanism for constitutive NF-¦ÊB activation, indicating the potentially pivotal role of miR-500 in the progression of gastric cancer. 1965 miR-500 hsa-miR-500a-5p,hsa-miR-500a-3p,hsa-miR-500b-5p,hsa-miR-500b-3p MIMAT0004773,MIMAT0002871,MIMAT0016925,MIMAT0027032 miRNA OTUD7B apoptosis down Homo sapiens non-small cell lung cancer cell 25595906 9606 56957 CEZANNE|ZA20D1 HGNC:16683|MIM:611748|HPRD:10313 1 1q21.2 OTU deubiquitinase 7B protein-coding OTU deubiquitinase 7B Here, we report that the miR-500 directly repressed the expression of CYLD, OTUD7B, and the A20 complex component Tax1-binding protein 1 (TAX1BP1), leading to ubiquitin conjugation of receptor-interacting protein 1 (RIP1) and sustained NF-??B activation. Furthermore, we found that miR-500 promoted gastric cancer cell proliferation, survival, and tumorigenicity. Importantly, miR-500 was upregulated in gastric cancer and was highly correlated with malignant progression and poor survival. Hence, we report the uncovering of a novel mechanism for constitutive NF-¦ÊB activation, indicating the potentially pivotal role of miR-500 in the progression of gastric cancer. 1966 miR-500 hsa-miR-500a-5p,hsa-miR-500a-3p,hsa-miR-500b-5p,hsa-miR-500b-3p MIMAT0004773,MIMAT0002871,MIMAT0016925,MIMAT0027032 miRNA RIPK1 apoptosis Homo sapiens non-small cell lung cancer cell 25595906 9606 8737 RIP|RIP1 HGNC:10019|MIM:603453|Ensembl:ENSG00000137275|HPRD:04583|Vega:OTTHUMG00000014134 6 6p25.2 receptor (TNFRSF)-interacting serine-threonine kinase 1 protein-coding receptor (TNFRSF)-interacting serine-threonine kinase 1 Here, we report that the miR-500 directly repressed the expression of CYLD, OTUD7B, and the A20 complex component Tax1-binding protein 1 (TAX1BP1), leading to ubiquitin conjugation of receptor-interacting protein 1 (RIP1) and sustained NF-??B activation. Furthermore, we found that miR-500 promoted gastric cancer cell proliferation, survival, and tumorigenicity. Importantly, miR-500 was upregulated in gastric cancer and was highly correlated with malignant progression and poor survival. Hence, we report the uncovering of a novel mechanism for constitutive NF-¦ÊB activation, indicating the potentially pivotal role of miR-500 in the progression of gastric cancer. 1967 miR-500 hsa-miR-500a-5p,hsa-miR-500a-3p,hsa-miR-500b-5p,hsa-miR-500b-3p MIMAT0004773,MIMAT0002871,MIMAT0016925,MIMAT0027032 miRNA TAX1BP1 apoptosis down Homo sapiens non-small cell lung cancer cell 25595906 9606 8887 CALCOCO3|T6BP|TXBP151 HGNC:11575|MIM:605326|Ensembl:ENSG00000106052|HPRD:05618|Vega:OTTHUMG00000023377 7 7p15 Tax1 (human T-cell leukemia virus type I) binding protein 1 protein-coding Tax1 (human T-cell leukemia virus type I) binding protein 1 Here, we report that the miR-500 directly repressed the expression of CYLD, OTUD7B, and the A20 complex component Tax1-binding protein 1 (TAX1BP1), leading to ubiquitin conjugation of receptor-interacting protein 1 (RIP1) and sustained NF-??B activation. Furthermore, we found that miR-500 promoted gastric cancer cell proliferation, survival, and tumorigenicity. Importantly, miR-500 was upregulated in gastric cancer and was highly correlated with malignant progression and poor survival. Hence, we report the uncovering of a novel mechanism for constitutive NF-¦ÊB activation, indicating the potentially pivotal role of miR-500 in the progression of gastric cancer. 1968 miR-501-5p hsa-miR-501-5p MIMAT0002872 miRNA MDM2 apoptosis up Homo sapiens renal cell 25426415 9606 4193 ACTFS|HDMX|hdm2 HGNC:6973|MIM:164785|Ensembl:ENSG00000135679|HPRD:01272|Vega:OTTHUMG00000142827 12 12q14.3-q15 MDM2 proto-oncogene, E3 ubiquitin protein ligase protein-coding MDM2 proto-oncogene, E3 ubiquitin protein ligase Our results support a role for miR501-5p in balancing apoptosis and cell survival in clear cell renal carcinoma. In particular, the downregulation of microRNA501-5p promotes a good prognosis, while its upregulation contributes to a poor prognosis, in particular, if associated with p53 and MDM2 overexpression and mTOR activation. Thus, the expression of miR501-5p is a possible biomarker for the prognosis of clear cell renal carcinoma. 1969 miR-501-5p hsa-miR-501-5p MIMAT0002872 miRNA MTOR apoptosis Homo sapiens renal cell 25426415 9606 2475 FRAP|FRAP1|FRAP2|RAFT1|RAPT1 HGNC:3942|MIM:601231|Ensembl:ENSG00000198793|HPRD:03134|Vega:OTTHUMG00000002001 1 1p36.2 mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) Our results support a role for miR501-5p in balancing apoptosis and cell survival in clear cell renal carcinoma. In particular, the downregulation of microRNA501-5p promotes a good prognosis, while its upregulation contributes to a poor prognosis, in particular, if associated with p53 and MDM2 overexpression and mTOR activation. Thus, the expression of miR501-5p is a possible biomarker for the prognosis of clear cell renal carcinoma. 1970 miR-501-5p hsa-miR-501-5p MIMAT0002872 miRNA TP53 apoptosis up Homo sapiens renal cell 25426415 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 Our results support a role for miR501-5p in balancing apoptosis and cell survival in clear cell renal carcinoma. In particular, the downregulation of microRNA501-5p promotes a good prognosis, while its upregulation contributes to a poor prognosis, in particular, if associated with p53 and MDM2 overexpression and mTOR activation. Thus, the expression of miR501-5p is a possible biomarker for the prognosis of clear cell renal carcinoma. 1971 miR-502-5p hsa-miR-502-5p MIMAT0002873 miRNA TRAF2 apoptosis down Homo sapiens breast cancer cell 24677135 9606 7186 MGC:45012|TRAP|TRAP3 HGNC:12032|MIM:601895|Ensembl:ENSG00000127191|HPRD:03538|Vega:OTTHUMG00000020952 9 9q34 TNF receptor-associated factor 2 protein-coding TNF receptor-associated factor 2 In vitro, miR-502-5p enhanced early apoptosis and inhibited proliferation of breast cancer cells. Luciferase reporter assay results showed that miR-502-5p could bind to the 3'-untranslated region of the TRAF2 gene, thus, exerting an inhibitory effect on TRAF2. 1972 miR-503 hsa-miR-503-5p,hsa-miR-503-3p MIMAT0022925,MIMAT0002874 miRNA ABCB1 apoptosis down Homo sapiens lung 24398307 9606 5243 ABC20|CD243|CLCS|GP170|MDR1|P-GP|PGY1 HGNC:40|MIM:171050|Ensembl:ENSG00000085563|HPRD:01370|Vega:OTTHUMG00000023393 7 7q21.12 ATP-binding cassette, sub-family B (MDR/TAP), member 1 protein-coding ATP-binding cassette, sub-family B (MDR/TAP), member 1 Apoptosis rate and intracellular concentration of rhodamine-123 (Rh-123) were determined by flow cytometry, the expression of multi-drugs resistant proteins MDR1 and MRP1, ERCC1, RhoE, Survivin and Bcl-2 were determined by Western blot and real time PCR. 1973 miR-503 hsa-miR-503-5p,hsa-miR-503-3p MIMAT0022925,MIMAT0002874 miRNA ABCC1 apoptosis down Homo sapiens lung 24398307 9606 4363 ABC29|ABCC|GS-X|MRP|MRP1 HGNC:51|MIM:158343|Ensembl:ENSG00000103222|HPRD:01153|Vega:OTTHUMG00000048267 16 16p13.1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 protein-coding ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Apoptosis rate and intracellular concentration of rhodamine-123 (Rh-123) were determined by flow cytometry, the expression of multi-drugs resistant proteins MDR1 and MRP1, ERCC1, RhoE, Survivin and Bcl-2 were determined by Western blot and real time PCR. 1974 miR-503 hsa-miR-503-5p,hsa-miR-503-3p MIMAT0002874,MIMAT0022925 miRNA AKT1 apoptosis down Homo sapiens glioblastoma cell 24378652 9606 207 AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA HGNC:391|MIM:164730|Ensembl:ENSG00000142208|HPRD:01261|Vega:OTTHUMG00000170795 14 14q32.32 v-akt murine thymoma viral oncogene homolog 1 protein-coding v-akt murine thymoma viral oncogene homolog 1 Furthermore, our results demonstrated that overexpression of miR-503 in GBM cell lines not only suppressed cell proliferation through inducing G0/G1 cell cycle arrest and apoptosis, but also inhibited cancer cell migration and tumor invasion. In addition, we identified insulin-like growth factor-1 (IGF?1R) receptor mRNA is a bona fide target of miR-503 by computational analysis followed by luciferase reporter assays. Of note, upregulation of miR-503 in GBM cells suppressed endogenous IGF-1R protein expression. Further mechanistic analysis revealed that forced expression of miR-503 inhibited AKT activation, suggesting the tumor suppressive effect of miR-503 in GBM cells is partially mediated by phosphatidylinositol 3-kinase/AKT signaling. 1975 miR-503 hsa-miR-503-5p,hsa-miR-503-3p MIMAT0002874,MIMAT0022925 miRNA BCL2 apoptosis down Homo sapiens non-small cell lung cancer cell 23856992 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Mechanistically, miR-503 specifically targeted Bcl-2, an anti-apoptotic protein upregulated in the A549/CDDP cells. The ectopic expression of miR-503 reduced the Bcl-2 protein level and sensitized the A549/CDDP cells to cisplatin-induced apoptosis. 1976 miR-503 hsa-miR-503-5p,hsa-miR-503-3p MIMAT0022925,MIMAT0002874 miRNA BCL2 apoptosis down Homo sapiens lung 24398307 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Apoptosis rate and intracellular concentration of rhodamine-123 (Rh-123) were determined by flow cytometry, the expression of multi-drugs resistant proteins MDR1 and MRP1, ERCC1, RhoE, Survivin and Bcl-2 were determined by Western blot and real time PCR. 1977 miR-503 hsa-miR-503-5p,hsa-miR-503-3p MIMAT0022925,MIMAT0002874 miRNA BCL2 apoptosis up Homo sapiens SGC7901 cell 24931256 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 MiR-503 was significantly downregulated in gastric cancer tissues and several gastric cancer cell lines. Additionally, downregulation of miR-503 in the cisplatin (DDP)-resistant gastric cancer cell line SGC7901/DDP was concurrent with the upregulation of insulin-like growth factor-1 receptor (IGF1R) and B-cell lymphoma 2 (BCL2) expression compared with the parental SGC7901 cell line. An in vitro drug sensitivity assay showed that overexpression of miR-503 sensitized SGC7901/DDP cells to cisplatin. The luciferase activity of reporters driven by IGF1R and BCL2 3'-untranslated regions in SGC7901/DDP cells suggested that IGF1R and BCL2 were both direct target genes of miR-503. Enforced miR-503 expression in SGC7901/DDP cells reduced expression of the target proteins, inhibited proliferation, and sensitized the cells to DDP-induced apoptosis. 1978 miR-503 hsa-miR-503-5p,hsa-miR-503-3p MIMAT0022925,MIMAT0002874 miRNA CELF1 apoptosis Homo sapiens epithelial cells 22072795 9606 10658 BRUNOL2|CUG-BP|CUGBP|CUGBP1|EDEN-BP|NAB50|NAPOR|hNab50 HGNC:2549|MIM:601074|Ensembl:ENSG00000149187|HPRD:03046 11 11p11 CUGBP, Elav-like family member 1 protein-coding CUGBP, Elav-like family member 1 50 kDa nuclear polyadenyl Repression of cugbp1 by miR-503 in turn altered the expression of CUGBP1 target mRNAs and thus increased the sensitivity of intestinal epithelial cells to apoptosis. 1979 miR-503 hsa-miR-503-5p,hsa-miR-503-3p MIMAT0022925,MIMAT0002874 miRNA ERCC1 apoptosis down Homo sapiens lung 24398307 9606 2067 COFS4|RAD10|UV20 HGNC:3433|MIM:126380|Ensembl:ENSG00000012061|HPRD:00533|Vega:OTTHUMG00000182121 19 19q13.32 excision repair cross-complementation group 1 protein-coding excision repair cross-complementation group 1 Apoptosis rate and intracellular concentration of rhodamine-123 (Rh-123) were determined by flow cytometry, the expression of multi-drugs resistant proteins MDR1 and MRP1, ERCC1, RhoE, Survivin and Bcl-2 were determined by Western blot and real time PCR. 1980 miR-503 hsa-miR-503-5p,hsa-miR-503-3p MIMAT0022925,MIMAT0002874 miRNA FANCA apoptosis down Homo sapiens non-small cell lung cancer cell 24486548 9606 2175 FA|FA-H|FA1|FAA|FACA|FAH|FANCH HGNC:3582|MIM:607139|Ensembl:ENSG00000187741|HPRD:06186|Vega:OTTHUMG00000173049 16 16q24.3 Fanconi anemia, complementation group A protein-coding Fanconi anemia, complementation group A Then, we show that miR-503 targets a homologous DNA region in the 3'-UTR region of the Fanconi anemia complementation group A protein (FANCA) gene and represses its expression at the transcriptional level. Taken together, our results suggest that miR-503 regulates the resistance of non-small cell lung cancer cells to cisplatin at least in part by targeting FANCA. 1981 miR-503 hsa-miR-503-5p,hsa-miR-503-3p MIMAT0002874,MIMAT0022925 miRNA IGF1R apoptosis down Homo sapiens glioblastoma cell 24378652 9606 3480 CD221|IGFIR|IGFR|JTK13 HGNC:5465|MIM:147370|Ensembl:ENSG00000140443|HPRD:00932|Vega:OTTHUMG00000149851 15 15q26.3 insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor Furthermore, our results demonstrated that overexpression of miR-503 in GBM cell lines not only suppressed cell proliferation through inducing G0/G1 cell cycle arrest and apoptosis, but also inhibited cancer cell migration and tumor invasion. In addition, we identified insulin-like growth factor-1 (IGF?1R) receptor mRNA is a bona fide target of miR-503 by computational analysis followed by luciferase reporter assays. Of note, upregulation of miR-503 in GBM cells suppressed endogenous IGF-1R protein expression. Further mechanistic analysis revealed that forced expression of miR-503 inhibited AKT activation, suggesting the tumor suppressive effect of miR-503 in GBM cells is partially mediated by phosphatidylinositol 3-kinase/AKT signaling. 1982 miR-503 hsa-miR-503-5p,hsa-miR-503-3p MIMAT0022925,MIMAT0002874 miRNA IGF1R apoptosis up Homo sapiens SGC7901 cell 24931256 9606 3480 CD221|IGFIR|IGFR|JTK13 HGNC:5465|MIM:147370|Ensembl:ENSG00000140443|HPRD:00932|Vega:OTTHUMG00000149851 15 15q26.3 insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor MiR-503 was significantly downregulated in gastric cancer tissues and several gastric cancer cell lines. Additionally, downregulation of miR-503 in the cisplatin (DDP)-resistant gastric cancer cell line SGC7901/DDP was concurrent with the upregulation of insulin-like growth factor-1 receptor (IGF1R) and B-cell lymphoma 2 (BCL2) expression compared with the parental SGC7901 cell line. An in vitro drug sensitivity assay showed that overexpression of miR-503 sensitized SGC7901/DDP cells to cisplatin. The luciferase activity of reporters driven by IGF1R and BCL2 3'-untranslated regions in SGC7901/DDP cells suggested that IGF1R and BCL2 were both direct target genes of miR-503. Enforced miR-503 expression in SGC7901/DDP cells reduced expression of the target proteins, inhibited proliferation, and sensitized the cells to DDP-induced apoptosis. 1983 miR-503 hsa-miR-503-5p,hsa-miR-503-3p MIMAT0022925,MIMAT0002874 miRNA RND3 apoptosis down Homo sapiens lung 24398307 9606 390 ARHE|Rho8|RhoE|memB HGNC:671|MIM:602924|Ensembl:ENSG00000115963|HPRD:04233|Vega:OTTHUMG00000131859 2 2q23.3 Rho family GTPase 3 protein-coding Rho family GTPase 3 Apoptosis rate and intracellular concentration of rhodamine-123 (Rh-123) were determined by flow cytometry, the expression of multi-drugs resistant proteins MDR1 and MRP1, ERCC1, RhoE, Survivin and Bcl-2 were determined by Western blot and real time PCR. 1984 miR-505 hsa-miR-505-5p, hsa-miR-505-3p MIMAT0004776,MIMAT0002876 miRNA AKT3 apoptosis down Homo sapiens breast cancer cell 22051041 9606 10000 MPPH|PKB-GAMMA|PKBG|PRKBG|RAC-PK-gamma|RAC-gamma|STK-2 HGNC:393|MIM:611223|Ensembl:ENSG00000117020|HPRD:06441|Vega:OTTHUMG00000039994 1 1q44 v-akt murine thymoma viral oncogene homolog 3 protein-coding v-akt murine thymoma viral oncogene homolog 3 MiR-505 is a novel tumor suppressive miRNA and inhibits cell proliferation by inducing apoptosis. We also find that Akt3, correlate inversely with miR-505, modulates drug sensitivity in MCF7-ADR. 1985 miR-506 hsa-miR-506-5p,hsa-miR-506-3p MIMAT0022701,MIMAT0002878 miRNA GLI3 apoptosis down Homo sapiens cervical cancer cell 24608427 9606 2737 ACLS|GCPS|GLI3-190|GLI3FL|PAP-A|PAPA|PAPA1|PAPB|PHS|PPDIV HGNC:4319|MIM:165240|Ensembl:ENSG00000106571|HPRD:01313|Vega:OTTHUMG00000023630 7 7p13 GLI family zinc finger 3 protein-coding GLI family zinc finger 3 Further studies showed that miR-506 induced cell cycle arrest at the G1/S transition, and enhanced apoptosis and chemosensitivity of cervical cancer cell. We subsequently identified Gli3, a hedgehog pathway transcription factor, as a direct target of miR-506 in cervical cancer. Furthermore, Gli3 silencing recapitulated the effects of miR-506, and reintroduction of Gli3 abrogated miR-506-induced cell growth arrest and apoptosis. 1986 miR-508-3p hsa-miR-508-3p MIMAT0002880 miRNA apoptosis Homo sapiens renal cell 22369946 9606 Identification of miR-508-3p and miR-509-3p that are associated with cell invasion and migration and involved in the apoptosis of renal cell carcinoma. 1987 miR-509 hsa-miR-509-5p,hsa-miR-509-3p,hsa-miR-509-3-5p MIMAT0004779,MIMAT0002881,MIMAT0004975 miRNA RAB5C apoptosis down Homo sapiens NALM6 cell 25368993 9606 5878 L1880|RAB5CL|RAB5L|RABL HGNC:9785|MIM:604037|Ensembl:ENSG00000108774|HPRD:04947|Vega:OTTHUMG00000169703 17 17q21.2 RAB5C, member RAS oncogene family protein-coding RAB5C, member RAS oncogene family MiR-509-transduced NALM6 cells had reduced numbers of actively proliferating cells and increased numbers of cells undergoing apoptosis. Using miR target prediction algorithms and a filtering strategy, RAB5C was predicted as a potentially relevant target of miR-509. Enforced miR-509 expression in NALM6 cells reduced RAB5C mRNA and protein levels, and RAB5C was demonstrated to be a direct target of miR-509. Knockdown of RAB5C in NALM6 cells recapitulated the growth inhibitory effects of miR-509. 1988 miR-509-3p hsa-miR-509-3p,hsa-miR-509-3-5p MIMAT0002881,MIMAT0004975 miRNA apoptosis Homo sapiens renal cell 22369946 9606 Identification of miR-508-3p and miR-509-3p that are associated with cell invasion and migration and involved in the apoptosis of renal cell carcinoma. 1989 miR-509-5p hsa-miR-509-5p MIMAT0004779 miRNA MDM2 apoptosis down Homo sapiens 25144722 9606 4193 ACTFS|HDMX|hdm2 HGNC:6973|MIM:164785|Ensembl:ENSG00000135679|HPRD:01272|Vega:OTTHUMG00000142827 12 12q14.3-q15 MDM2 proto-oncogene, E3 ubiquitin protein ligase protein-coding MDM2 proto-oncogene, E3 ubiquitin protein ligase Here, we provide evidence that miR-509-5p, which is downregulated in a subset of newly diagnosed cervical cancer and hepatocellular carcinoma tissues compared with the adjacent nontumor tissue, can be activated by p53 through binding the promoter of miR-509-5p and it suppresses the growth and invasion/migration of cervical cancer and hepatoma cells by regulating apoptosis and the G1/S-phase transition of cell cycle. Furthermore, Mdm2 was identified to be a target of miR-509-5p by targeting its 3'-UTR. Restoration of Mdm2 abrogated the cell phenotypes induced by miR-509-5p. Moreover, ectopic expression of miR-509-5p in HeLa and QGY-7703 cells repressed the expression of Mdm2, subsequently enhancing its p53-activating effects. These results suggest that miR-509-5p is a new regulator of Mdm2/p53 pathway and may play a key role in cancer development. 1990 miR-509-5p hsa-miR-509-5p MIMAT0004779 miRNA TP53 apoptosis down Homo sapiens 25144722 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 Here, we provide evidence that miR-509-5p, which is downregulated in a subset of newly diagnosed cervical cancer and hepatocellular carcinoma tissues compared with the adjacent nontumor tissue, can be activated by p53 through binding the promoter of miR-509-5p and it suppresses the growth and invasion/migration of cervical cancer and hepatoma cells by regulating apoptosis and the G1/S-phase transition of cell cycle. Furthermore, Mdm2 was identified to be a target of miR-509-5p by targeting its 3'-UTR. Restoration of Mdm2 abrogated the cell phenotypes induced by miR-509-5p. Moreover, ectopic expression of miR-509-5p in HeLa and QGY-7703 cells repressed the expression of Mdm2, subsequently enhancing its p53-activating effects. These results suggest that miR-509-5p is a new regulator of Mdm2/p53 pathway and may play a key role in cancer development. 1991 miR-509-5p hsa-miR-509-5p MIMAT0004779 miRNA apoptosis Homo sapiens renal cell 23619562 9606 We evaluated the expression level of miR-509-5p in RCC tissues and paired adjacent normal tissues from 42 patients and found that miR-509-5p expression in 42 RCC specimens was significantly down-regulated compared to that in adjacent normal tissue. Furthermore, the level of miR-509-5p in RCC patients' plasma was significantly lower than that in control plasma. In addition, the overexpression of miR-509-5p suppressed the proliferation of RCC cell (786-0), induced cell apoptosis and inhibited cell migration in vitro. 1992 miR-511 hsa-miR-511-5p,hsa-miR-511-3p MIMAT0002808,MIMAT0026606 miRNA BAX apoptosis up Homo sapiens lung cancer cell 24402374 9606 581 BCL2L4 HGNC:959|MIM:600040|Ensembl:ENSG00000087088|HPRD:02498|Vega:OTTHUMG00000160476 19 19q13.3-q13.4 BCL2-associated X protein protein-coding BCL2-associated X protein MiR-511 induces the apoptosis of radioresistant lung adenocarcinoma cells by triggering BAX. 1993 miR-511 hsa-miR-511-5p,hsa-miR-511-3p MIMAT0002808,MIMAT0026606 miRNA TRIB2 apoptosis down Homo sapiens lung adenocarcinoma cell 23071539 9606 28951 C5FW|GS3955|TRB2 HGNC:30809|MIM:609462|Ensembl:ENSG00000071575|HPRD:18224|Vega:OTTHUMG00000090575 2 2p24.3 tribbles pseudokinase 2 protein-coding tribbles pseudokinase 2 The MTT test showed inhibition of A549 cell proliferation and Annexin V-FITC/PI dual staining showed increased apoptosis in the miR-511- and miR-1297-treated cells compared to the NC cultures. A transcription factor downstream of TRIB2, the CCAAT/enhancer-binding protein alpha (C/EBP¦Á), was expression at higher levels after miR-511 (or miR-1297) decreasing TRIB2 expression. 1994 miR-512 hsa-miR-512-5p£¬hsa-miR-512-3p MIMAT0002822,MIMAT0002823 miRNA TEAD4 apoptosis Homo sapiens lung cancer cell 25591738 9606 7004 EFTR-2|RTEF1|TCF13L1|TEF-3|TEF3|TEFR-1|hRTEF-1B HGNC:11717|MIM:601714|Ensembl:ENSG00000197905|HPRD:03421|Vega:OTTHUMG00000168153 12 12p13.3-p13.2 TEA domain family member 4 protein-coding TEA domain family member 4 Re-expression of both miRs augmented cisplatin-induced apoptosis and inhibited cell migration; miR-512 also reduced cell proliferation. TEAD4 mRNA was confirmed as a direct target of miR-512; likewise, miR-373 was found to target RelA and PIK3CA mRNA directly. Our results imply that miR-512 and miR-373 exert cell-autonomous and non-autonomous tumor-suppressive effects in lung cancer cells, where their re-expression may benefit epigenetic cancer therapy.Cell Death and Differentiation advance online 1995 miR-512-3p hsa-miR-512-3p MIMAT0002823 miRNA CFLAR apoptosis down Homo sapiens hepatocellular carcinoma cells 20372864 9606 8837 CASH|CASP8AP1|CLARP|Casper|FLAME|FLAME-1|FLAME1|FLIP|I-FLICE|MRIT|c-FLIP|c-FLIPL|c-FLIPR|c-FLIPS HGNC:1876|MIM:603599|Ensembl:ENSG00000003402|HPRD:04671|Vega:OTTHUMG00000132819 2 2q33-q34 CASP8 and FADD-like apoptosis regulator protein-coding CASP8 and FADD-like apoptosis regulator FADD-like anti-apoptotic Inhibition of c-FLIP expression by miR-512-3p contributes to taxol-induced apoptosis in hepatocellular carcinoma cells. 1996 miR-513 hsa-miR-513a-5p,hsa-miR-513a-3p,hsa-miR-513b-5p,hsa-miR-513b-3p MIMAT0002877,MIMAT0004777,MIMAT0005788,MIMAT0026749 miRNA CD274 apoptosis Homo sapiens epithelial cell 19916867 9606 29126 B7-H|B7H1|PD-L1|PDCD1L1|PDCD1LG1|PDL1 HGNC:17635|MIM:605402|Ensembl:ENSG00000120217|HPRD:05655|Vega:OTTHUMG00000019503 9 9p24 CD274 molecule protein-coding CD274 molecule Overexpression of miR-513 through transfection of miR-513 precursor inhibited C. parvum-induced B7-H1 protein expression. Moreover, enhanced apoptotic cell death was identified in activated human T cells after coculture with C. parvum-infected cholangiocytes. The apoptosis of activated T cells was partially blocked by a neutralizing antibody to B7-H1 or transfection of cholangiocytes with miR-513 precursor. These data suggest a role of miR-513 in regulating B7-H1 expression by cholangiocytes in response to C. parvum infection. 1997 miR-513a-5p hsa-miR-513a-5p MIMAT0002877 miRNA XIAP apoptosis up Homo sapiens human umbilical vein endothelial cells 22504158 9606 331 API3|BIRC4|IAP-3|ILP1|MIHA|XLP2|hIAP-3|hIAP3 HGNC:592|MIM:300079|Ensembl:ENSG00000101966|HPRD:02094|Vega:OTTHUMG00000022336 X Xq25 X-linked inhibitor of apoptosis protein-coding X-linked inhibitor of apoptosis These results together suggest that miR-513a-5p mediates TNF-¦Á and LPS induced apoptosis via downregulation of XIAP in HUVECs. 1998 miR-513b hsa-miR-513b-5p,hsa-miR-513b-3p MIMAT0005788,MIMAT0026749 miRNA HMGB3 apoptosis Homo sapiens gastric cancer 25095979 9606 3149 HMG-2a|HMG-4|HMG2A|HMG4|MCOPS13 HGNC:5004|MIM:300193|Ensembl:ENSG00000029993|HPRD:02181|Vega:OTTHUMG00000024162 X Xq28 high mobility group box 3 protein-coding high mobility group box 3 In western blot and luciferase assays, HMGB3 was identified as a major target of miR-513b. Moreover, we also found that the expression of HMGB3 lacking in 3' UTR could abrogate the anti-migration and pro-apoptosis function of miR-513b. These findings suggest the importance of miR-513b targeting of HMGB3 in the regulation of growth, migration and apoptosis of GC, improve our understanding of the mechanisms of GC pathogenesis, and may promote the development of novel targeted therapies. 1999 miR-515-5p hsa-miR-515-5p MIMAT0002826 miRNA PAPSS1 apoptosis down Homo sapiens breast cancer cells 23928990 9606 9061 ATPSK1|PAPSS|SK1 HGNC:8603|MIM:603262|Ensembl:ENSG00000138801|HPRD:09132|Vega:OTTHUMG00000131210 4 4q24 3'-phosphoadenosine 5'-phosphosulfate synthase 1 protein-coding 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Enforced expression of miR-515-5p in breast cancer cells causes a reduction in SK1 activity, reduced cell proliferation, and the induction of caspase-dependent apoptosis. 2000 miR-517a hsa-miR-517-5p,hsa-miR-517-3p MIMAT0002851,MIMAT0002852 miRNA AREG apoptosis Homo sapiens bladder cancer (BC) cell 21479368 9606 374 AR|AREGB|CRDGF|SDGF HGNC:651|MIM:104640|Ensembl:ENSG00000109321|Ensembl:ENSG00000205595|HPRD:00093|Vega:OTTHUMG00000130006|Vega:OTTHUMG00000160870 4 4q13.3 amphiregulin protein-coding amphiregulin These included amphiregulin (AREG) and BCL2-associated transcription factor 1, transcript variant 1 (BCLAF1), previously reported to be concerned with apoptosis, in both cell lines by miR-517a restoration. These data suggest that miR-517a functions as a tumor suppressor through inhibition of cell proliferation and induction of apoptosis under the regulation of AREG and/or BCLAF1 in BC cells. 2001 miR-517a hsa-miR-517-5p,hsa-miR-517-3p MIMAT0002851,MIMAT0002852 miRNA BCLAF1 apoptosis Homo sapiens bladder cancer (BC) cell 21479368 9606 9774 BTF|bK211L9.1 HGNC:16863|MIM:612588|Ensembl:ENSG00000029363|HPRD:16544|Vega:OTTHUMG00000033323 6 6q22-q23 BCL2-associated transcription factor 1 protein-coding BCL2-associated transcription factor 1 These included amphiregulin (AREG) and BCL2-associated transcription factor 1, transcript variant 1 (BCLAF1), previously reported to be concerned with apoptosis, in both cell lines by miR-517a restoration. These data suggest that miR-517a functions as a tumor suppressor through inhibition of cell proliferation and induction of apoptosis under the regulation of AREG and/or BCLAF1 in BC cells. Anti-apoptotic effects may be maintained by down-regulation of miR-517a due to DNA hypermethylation in human BC cells, suggesting that restoration of miR-517a may be a novel therapeutic strategy for human BC. 2002 miR-518b hsa-miR-518b MIMAT0002844 miRNA RAP1B apoptosis up Homo sapiens esophageal squamous cell carcinoma cells 22958893 9606 5908 K-REV|RAL1B HGNC:9857|MIM:179530|Ensembl:ENSG00000127314|HPRD:01546|Vega:OTTHUMG00000133660 12 12q14 RAP1B, member of RAS oncogene family protein-coding RAP1B, member of RAS oncogene family miR-518b suppressed the proliferation by inducing apoptosis and repressed the invasion in ESCC cells, but had no effect on the cell cycle. Furthermore, Rap1b was revealed to be directly regulated by miR-518b. 2003 miR-519a hsa-miR-519a-3p,hsa-miR-519a-5p MIMAT0002869,MIMAT0005452 miRNA apoptosis Homo sapiens breast cancer cell 24752803 9606 Combined expression of these target genes correlated with disease-specific survival in a cohort of tamoxifen-treated patients. We identified miRNA-519a as a novel oncomir in ER+ breast cancer cells as it increased cell viability and cell cycle progression as well as resistance to tamoxifen-induced apoptosis. Finally, we could show that elevated miRNA-519a levels were inversely correlated with the target genes' expression and that higher expression of this miRNA correlated with poorer survival in ER+ breast cancer patients. Hence we have identified miRNA-519a as a novel oncomir, co-regulating a network of TSGs in breast cancer and conferring resistance to tamoxifen. Using inhibitors of such miRNAs may serve as a novel therapeutic approach to combat resistance to therapy as well as proliferation and evasion of apoptosis in breast cancer. 2004 miR-519d hsa-miR-519d-3p,hsa-miR-519d-5p MIMAT0002853,MIMAT0026610 miRNA AKT3 apoptosis down Homo sapiens hepatocellular carcinoma cells 22262409 9606 10000 MPPH|PKB-GAMMA|PKBG|PRKBG|RAC-PK-gamma|RAC-gamma|STK-2 HGNC:393|MIM:611223|Ensembl:ENSG00000117020|HPRD:06441|Vega:OTTHUMG00000039994 1 1q44 v-akt murine thymoma viral oncogene homolog 3 protein-coding v-akt murine thymoma viral oncogene homolog 3 In HCC cells, the over-expression of miR-519d promotes cell proliferation, invasion and impairs apoptosis following anticancer treatments. These functions are, at least in part, exerted through the direct targeting of CDKN1A/p21, PTEN, AKT3 and TIMP2. 2005 miR-519d hsa-miR-519d-3p,hsa-miR-519d-5p MIMAT0002853,MIMAT0026610 miRNA CDKN1A apoptosis up Homo sapiens hepatocellular carcinoma cells 22262409 9606 1026 CAP20|CDKN1|CIP1|MDA-6|P21|SDI1|WAF1|p21CIP1 HGNC:1784|MIM:116899|Ensembl:ENSG00000124762|HPRD:00298|Vega:OTTHUMG00000014603 6 6p21.2 cyclin-dependent kinase inhibitor 1A (p21, Cip1) protein-coding cyclin-dependent kinase inhibitor 1A (p21, Cip1) In HCC cells, the over-expression of miR-519d promotes cell proliferation, invasion and impairs apoptosis following anticancer treatments. These functions are, at least in part, exerted through the direct targeting of CDKN1A/p21, PTEN, AKT3 and TIMP2. 2006 miR-519d hsa-miR-519d-3p,hsa-miR-519d-5p MIMAT0002853,MIMAT0026610 miRNA PTEN apoptosis down Homo sapiens Hepatocellular carcinoma cells 22262409 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog In HCC cells, the over-expression of miR-519d promotes cell proliferation, invasion and impairs apoptosis following anticancer treatments. These functions are, at least in part, exerted through the direct targeting of CDKN1A/p21, PTEN, AKT3 and TIMP2. 2007 miR-519d hsa-miR-519d-3p,hsa-miR-519d-5p MIMAT0002853,MIMAT0026610 miRNA TIMP2 apoptosis up Homo sapiens hepatocellular carcinoma cells 22262409 9606 7077 CSC-21K|DDC8 HGNC:11821|MIM:188825|Ensembl:ENSG00000035862|HPRD:01784|Vega:OTTHUMG00000154517 17 17q25 TIMP metallopeptidase inhibitor 2 protein-coding TIMP metallopeptidase inhibitor 2 In HCC cells, the over-expression of miR-519d promotes cell proliferation, invasion and impairs apoptosis following anticancer treatments. These functions are, at least in part, exerted through the direct targeting of CDKN1A/p21, PTEN, AKT3 and TIMP2. 2008 miR-519d hsa-miR-519d-3p,hsa-miR-519d-5p MIMAT0002853,MIMAT0026610 miRNA XIAP apoptosis down Homo sapiens ovarian cancer cell 24790458 9606 331 API3|BIRC4|IAP-3|ILP1|MIHA|XLP2|hIAP-3|hIAP3 HGNC:592|MIM:300079|Ensembl:ENSG00000101966|HPRD:02094|Vega:OTTHUMG00000022336 X Xq25 X-linked inhibitor of apoptosis protein-coding X-linked inhibitor of apoptosis MiR-519d binding sites on the 3' untranslated region of X-linked inhibitor of apoptosis protein (XIAP).Overexpression of miR-519d decreased XIAP expression at both the protein and mRNA levels. The expression levels of XIAP mRNA and protein were examined by quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting assay, respectively. 2009 miR-520a-5p hsa-miR-520a-5p MIMAT0002833 miRNA STAT3 apoptosis down Homo sapiens chronic myelogenous leukemia cell 24870597 9606 6774 APRF|HIES HGNC:11364|MIM:102582|Ensembl:ENSG00000168610|HPRD:00026|Vega:OTTHUMG00000150645 17 17q21.31 signal transducer and activator of transcription 3 (acute-phase response factor) protein-coding signal transducer and activator of transcription 3 (acute-phase response factor) Finally, we observed the effects of capsaicin following miR-520a-5p inhibitor transfection upon cell proliferation, apoptosis, and STAT3 expression levels. We determined that, downregulation of miR-520a-5p affected the proliferation inhibition enhanced by capsaicin and reduced STAT3 mRNA and protein expression levels and increased apoptotic cell number. In summary, miR-520a-5p displays a therapeutic effect by targeting STAT3 and impacting the anticancer effects of capsaicin; whereas capsaicin, potentially through the miR-520a-5p/STAT3 interaction, induces apoptosis and inhibits K562 leukemic cell proliferation with need of further investigation. 2010 miR-520f hsa-miR-520f-5p,hsa-miR-520f-3p MIMAT0026609,MIMAT0002830 miRNA NAIP apoptosis up Homo sapiens SK-N-AsCis24 cell 25137037 9606 4671 BIRC1|NLRB1|psiNAIP HGNC:7634|MIM:600355|Ensembl:ENSG00000249437|Vega:OTTHUMG00000163318 5 5q13.2 NLR family, apoptosis inhibitory protein protein-coding NLR family, apoptosis inhibitory protein High resolution aCGH analysis of SK-N-AsCis24 revealed a focal gain on chromosome 5 containing the coding sequence for the neural apoptosis inhibitory protein (NAIP). Significant overexpression of NAIP mRNA and protein was documented, while experimental modulation of NAIP levels in both SK-N-AsCis24 and in parental SK-N-AS cells confirmed that NAIP was responsible for the drug resistant phenotype by apoptosis inhibition. Furthermore, a decrease in the NAIP targeting microRNA, miR-520f, was also demonstrated to be partially responsible for increased NAIP levels in SK-N-AsCis24. 2011 miR-526b hsa-miR-526b-5p,hsa-miR-526b-3p MIMAT0002836,MIMAT0002835 miRNA XRCC5 apoptosis down Homo sapiens non-small cell lung cancer cell 25596743 9606 7520 KARP-1|KARP1|KU80|KUB2|Ku86|NFIV HGNC:12833|MIM:194364|Ensembl:ENSG00000079246|HPRD:08935|Vega:OTTHUMG00000133059 2 2q35 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) protein-coding X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) We found that ORP8 is down-regulated, whereas miR-143, which controls ORP8 expression, is up-regulated in clinical HCC tissues as compared with liver tissue from healthy subjects. ORP8 overexpression triggered apoptosis in primary HCC cells and cell lines, which coincided with a relocation of cytoplasmic Fas to the cell plasma membrane and FasL up-regulation. 2012 miR-542-3p hsa-miR-542-3p MIMAT0003389 miRNA BIRC5 apoptosis down Homo sapiens A549 cell 20728447 9606 332 API4|EPR-1 HGNC:593|MIM:603352|Ensembl:ENSG00000089685|HPRD:04520|Vega:OTTHUMG00000177505 17 17q25 baculoviral IAP repeat containing 5 protein-coding baculoviral IAP repeat containing 5 Survivin is a protein which functions as a mitotic regulator as well as apoptosis inhibitor. In this study, we show that introduction of synthetic miR-542-3p mimetic reduced both mRNA and protein levels of survivin. 2013 miR-542-3p hsa-miR-542-3p MIMAT0003389 miRNA BIRC5 apoptosis down Homo sapiens neuroblastoma cell 25046253 9606 332 API4|EPR-1 HGNC:593|MIM:603352|Ensembl:ENSG00000089685|HPRD:04520|Vega:OTTHUMG00000177505 17 17q25 baculoviral IAP repeat containing 5 protein-coding baculoviral IAP repeat containing 5 Ectopic expression of miR-542-3p in neuroblastoma cell lines reduced cell viability and proliferation, induced apoptosis and downregulated Survivin. Survivin expression was also inversely correlated with miR-542-3p expression in primary neuroblastomas. Reporter assays confirmed that miR-542-3p directly targeted Survivin. 2014 miR-542-3p hsa-miR-542-3p MIMAT0003389 miRNA BMP7 apoptosis down Homo sapiens osteoblast 24503542 9606 655 OP-1 HGNC:1074|MIM:112267|Ensembl:ENSG00000101144|HPRD:00212|Vega:OTTHUMG00000032812 20 20q13 bone morphogenetic protein 7 protein-coding bone morphogenetic protein 7 It was seen that over-expression of miR-542-3p leads to repression of BMP-7 and inhibition of BMP-7/PI3K- survivin signaling. 2015 miR-545 hsa-miR-545-3p,hsa-miR-545-5p MIMAT0004785,MIMAT0003165 miRNA CCND1 apoptosis down Homo sapiens lung cancer cell 24505359 9606 595 BCL1|D11S287E|PRAD1|U21B31 HGNC:1582|MIM:168461|Ensembl:ENSG00000110092|HPRD:01346|Vega:OTTHUMG00000167877 11 11q13 cyclin D1 protein-coding cyclin D1 We also found that miR-545 caused cell cycle arrest at the G0/G1 phase and induced cell apoptosis in lung cancer cells by targeting cyclin D1 and CDK4 genes. The effects of cyclin D1 and CDK4 down-regulated by miR-545 were similar to those caused by siRNAs of cyclin D1 and CDK4, and overexpression of cyclin D1 and CDK4 could abolish the miR-545-induced inhibition of cell proliferation. 2016 miR-545 hsa-miR-545-3p,hsa-miR-545-5p MIMAT0004785,MIMAT0003165 miRNA CDK4 apoptosis down Homo sapiens lung cancer cell 24505359 9606 1019 CMM3|PSK-J3 HGNC:1773|MIM:123829|Ensembl:ENSG00000135446|HPRD:00447|Vega:OTTHUMG00000170382 12 12q14 cyclin-dependent kinase 4 protein-coding cyclin-dependent kinase 4 We also found that miR-545 caused cell cycle arrest at the G0/G1 phase and induced cell apoptosis in lung cancer cells by targeting cyclin D1 and CDK4 genes. The effects of cyclin D1 and CDK4 down-regulated by miR-545 were similar to those caused by siRNAs of cyclin D1 and CDK4, and overexpression of cyclin D1 and CDK4 could abolish the miR-545-induced inhibition of cell proliferation. 2017 miR-548b hsa-miR-548b-5p,hsa-miR-548b-3p MIMAT0004798,MIMAT0003254 miRNA AXL apoptosis Homo sapiens NSCLC cell 24832599 9606 558 JTK11|UFO HGNC:905|MIM:109135|Ensembl:ENSG00000167601|HPRD:00171|Vega:OTTHUMG00000182727 19 19q13.1 AXL receptor tyrosine kinase protein-coding AXL receptor tyrosine kinase In this study, we validate and report that miR-374a and miR-548b modulated by Axl have essential roles in cell cycle arrest, gefitinib-induced apoptosis, epithelial-to-mesenchymal transition, migration and tumorigenesis of gefitinib-resistant lung cancer cells in vitro and in vivo by targeting Wnt5a and CCNB1 genes, respectively. 2018 miR-548b hsa-miR-548b-5p,hsa-miR-548b-3p MIMAT0004798,MIMAT0003254 miRNA CCNB1 apoptosis Homo sapiens NSCLC cell 24832599 9606 891 CCNB HGNC:1579|MIM:123836|Ensembl:ENSG00000134057|HPRD:00454|Vega:OTTHUMG00000097817 5 5q12 cyclin B1 protein-coding cyclin B1 In this study, we validate and report that miR-374a and miR-548b modulated by Axl have essential roles in cell cycle arrest, gefitinib-induced apoptosis, epithelial-to-mesenchymal transition, migration and tumorigenesis of gefitinib-resistant lung cancer cells in vitro and in vivo by targeting Wnt5a and CCNB1 genes, respectively. 2019 miR-548c-5p hsa-miR-548c-5p MIMAT0004806 miRNA BCL2 apoptosis down Homo sapiens CD90(+) Hepatocellular carcinoma cells 23077462 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Moreover, the miR-548c-5p transfection could down-regulate the expression of ¦Â-catenin, Tg737, bcl-2, bcl-XL, and caspase-3, inhibit the proliferation, migration and invasion and promote the apoptosis of the CD90(+) HepG2 cells. 2020 miR-548c-5p hsa-miR-548c-5p MIMAT0004806 miRNA BCL2L1 apoptosis down Homo sapiens CD91(+) Hepatocellular carcinoma cells 23077462 9606 598 BCL-XL/S|BCL2L|BCLX|BCLXL|BCLXS|Bcl-X|PPP1R52|bcl-xL|bcl-xS HGNC:992|MIM:600039|Ensembl:ENSG00000171552|HPRD:02497|Vega:OTTHUMG00000032192 20 20q11.21 BCL2-like 1 protein-coding BCL2-like 1 Moreover, the miR-548c-5p transfection could down-regulate the expression of ¦Â-catenin, Tg737, bcl-2, bcl-XL, and caspase-3, inhibit the proliferation, migration and invasion and promote the apoptosis of the CD90(+) HepG2 cells. 2021 miR-548c-5p hsa-miR-548c-5p MIMAT0004806 miRNA CASP3 apoptosis down Homo sapiens CD92(+) Hepatocellular carcinoma cells 23077462 9606 836 CPP32|CPP32B|SCA-1 HGNC:1504|MIM:600636|Ensembl:ENSG00000164305|HPRD:02799|Vega:OTTHUMG00000133681 4 4q34 caspase 3, apoptosis-related cysteine peptidase protein-coding caspase 3, apoptosis-related cysteine peptidase Moreover, the miR-548c-5p transfection could down-regulate the expression of ¦Â-catenin, Tg737, bcl-2, bcl-XL, and caspase-3, inhibit the proliferation, migration and invasion and promote the apoptosis of the CD90(+) HepG2 cells. 2022 miR-548c-5p hsa-miR-548c-5p MIMAT0004806 miRNA CTNNB1 apoptosis down Homo sapiens CD91(+) Hepatocellular carcinoma cells 23077462 9606 1499 CTNNB|MRD19|armadillo HGNC:2514|MIM:116806|Ensembl:ENSG00000168036|HPRD:00286|Vega:OTTHUMG00000131393 3 3p21 catenin (cadherin-associated protein), beta 1, 88kDa protein-coding catenin (cadherin-associated protein), beta 1, 88kDa Moreover, the miR-548c-5p transfection could down-regulate the expression of ¦Â-catenin, Tg737, bcl-2, bcl-XL, and caspase-3, inhibit the proliferation, migration and invasion and promote the apoptosis of the CD90(+) HepG2 cells. 2023 miR-548c-5p hsa-miR-548c-5p MIMAT0004806 miRNA IFT88 apoptosis down Homo sapiens CD92(+) Hepatocellular carcinoma cells 23077462 9606 8100 D13S1056E|DAF19|TG737|TTC10|hTg737 HGNC:20606|MIM:600595|Ensembl:ENSG00000032742|HPRD:09000|Vega:OTTHUMG00000016517 13 13q12.1 intraflagellar transport 88 protein-coding intraflagellar transport 88 Moreover, the miR-548c-5p transfection could down-regulate the expression of ¦Â-catenin, Tg737, bcl-2, bcl-XL, and caspase-3, inhibit the proliferation, migration and invasion and promote the apoptosis of the CD90(+) HepG2 cells. 2024 miR-551b hsa-miR-551b-3p,hsa-miR-551b-5p MIMAT0004794,MIMAT0003233 miRNA CAT apoptosis down Homo sapiens AR cell 25085901 9606 847 - HGNC:1516|MIM:115500|Ensembl:ENSG00000121691|HPRD:00282|Vega:OTTHUMG00000044353 11 11p13 catalase protein-coding catalase Decreased catalase expression and increased cellular reactive oxygen species (ROS) accumulation were found to be associated with MUC1 overexpression. Scavenging ROS with butylated hydroxyanisole or supplying exogenous catalase dramatically suppressed MUC1 expression through destabilizing MUC1 protein, suggesting that reduced catalase expression mediated ROS accumulation is accounted for MUC1 overexpression. Further, we found that increased miR-551b expression in the AR cells inhibited the expression of catalase and potentiated ROS accumulation and MUC1 expression. 2025 miR-551b hsa-miR-551b-3p,hsa-miR-551b-5p MIMAT0004794,MIMAT0003233 miRNA MUC1 apoptosis down Homo sapiens AR cell 25085901 9606 4582 ADMCKD|ADMCKD1|CA 15-3|CD227|EMA|H23AG|KL-6|MAM6|MCD|MCKD|MCKD1|MUC-1|MUC-1/SEC|MUC-1/X|MUC1/ZD|PEM|PEMT|PUM HGNC:7508|MIM:158340|Ensembl:ENSG00000185499|HPRD:01152|Vega:OTTHUMG00000035681 1 1q21 mucin 1, cell surface associated protein-coding mucin 1, cell surface associated Decreased catalase expression and increased cellular reactive oxygen species (ROS) accumulation were found to be associated with MUC1 overexpression. Scavenging ROS with butylated hydroxyanisole or supplying exogenous catalase dramatically suppressed MUC1 expression through destabilizing MUC1 protein, suggesting that reduced catalase expression mediated ROS accumulation is accounted for MUC1 overexpression. Further, we found that increased miR-551b expression in the AR cells inhibited the expression of catalase and potentiated ROS accumulation and MUC1 expression. 2026 miR-574-3p hsa-miR-574-3p MIMAT0003239 miRNA BCL2L1 apoptosis up Homo sapiens pancreatic cancer cell line cells 23554959 9606 598 BCL-XL/S|BCL2L|BCLX|BCLXL|BCLXS|Bcl-X|PPP1R52|bcl-xL|bcl-xS HGNC:992|MIM:600039|Ensembl:ENSG00000171552|HPRD:02497|Vega:OTTHUMG00000032192 20 20q11.21 BCL2-like 1 protein-coding BCL2-like 1 miR-574-3p restoration induced apoptosis through reducing Bcl-xL and activating caspase-9 and caspase-3. 2027 miR-574-3p hsa-miR-574-3p MIMAT0003239 miRNA CASP3 apoptosis up Homo sapiens pancreatic cancer cell line cells 23554959 9606 836 CPP32|CPP32B|SCA-1 HGNC:1504|MIM:600636|Ensembl:ENSG00000164305|HPRD:02799|Vega:OTTHUMG00000133681 4 4q34 caspase 3, apoptosis-related cysteine peptidase protein-coding caspase 3, apoptosis-related cysteine peptidase miR-574-3p restoration induced apoptosis through reducing Bcl-xL and activating caspase-9 and caspase-3. 2028 miR-574-3p hsa-miR-574-3p MIMAT0003239 miRNA CASP9 apoptosis up Homo sapiens pancreatic cancer cell line cells 23554959 9606 842 APAF-3|APAF3|ICE-LAP6|MCH6|PPP1R56 HGNC:1511|MIM:602234|Ensembl:ENSG00000132906|HPRD:03756|Vega:OTTHUMG00000002256 1 1p36.21 caspase 9, apoptosis-related cysteine peptidase protein-coding caspase 9, apoptosis-related cysteine peptidase miR-574-3p restoration induced apoptosis through reducing Bcl-xL and activating caspase-9 and caspase-3. 2029 miR-574-3p hsa-miR-574-3p MIMAT0003239 miRNA MESDC1 apoptosis Homo sapiens bladder cancer cell 22179486 9606 59274 - HGNC:13519|MIM:615466|Ensembl:ENSG00000140406|HPRD:11300|Vega:OTTHUMG00000144185 15 15q13 mesoderm development candidate 1 protein-coding mesoderm development candidate 1 Flow cytometry analysis showed that cell apoptosis was induced in miR-574-3p transfectants. Oligo microarray analysis suggested that the mesoderm development candidate 1 (MESDC1) gene was a target gene in miR-574-3p transfectants. 2030 miR-574-5p hsa-miR-574-3p MIMAT0003239 miRNA PTCSC3 apoptosis Homo sapiens thyroid 23599737 9606 100886964 - HGNC:43959|MIM:614821 14 14q13.3 papillary thyroid carcinoma susceptibility candidate 3 (non-protein coding) ncRNA papillary thyroid carcinoma susceptibility candidate 3 (non-protein coding) Following transfection with PTCSC3, all three thyroid cancer cells originating from various pathological types of thyroid cancers demonstrated significant growth inhibition,cell cycle arrest and increased apoptosis.PTCSC3 as a tumor suppressor was investigated as a competing endogenous RNA for miR-574-5p. 2031 miR-582-5p hsa-miR-582-5p MIMAT0003247 miRNA BCL2L11 apoptosis down Homo sapiens glioblastoma stem cell 24805821 9606 10018 BAM|BIM|BOD HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 2 2q13 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) Novel anti-apoptotic microRNAs 582-5p and 363 promote human glioblastoma stem cell survival via direct inhibition of caspase 3, caspase 9, and Bim. 2032 miR-582-5p hsa-miR-582-5p MIMAT0003247 miRNA CASP3 apoptosis down Homo sapiens glioblastoma stem cell 24805821 9606 836 CPP32|CPP32B|SCA-1 HGNC:1504|MIM:600636|Ensembl:ENSG00000164305|HPRD:02799|Vega:OTTHUMG00000133681 4 4q34 caspase 3, apoptosis-related cysteine peptidase protein-coding caspase 3, apoptosis-related cysteine peptidase Novel anti-apoptotic microRNAs 582-5p and 363 promote human glioblastoma stem cell survival via direct inhibition of caspase 3, caspase 9, and Bim. 2033 miR-582-5p hsa-miR-582-5p MIMAT0003247 miRNA CASP9 apoptosis down Homo sapiens glioblastoma stem cell 24805821 9606 842 APAF-3|APAF3|ICE-LAP6|MCH6|PPP1R56 HGNC:1511|MIM:602234|Ensembl:ENSG00000132906|HPRD:03756|Vega:OTTHUMG00000002256 1 1p36.21 caspase 9, apoptosis-related cysteine peptidase protein-coding caspase 9, apoptosis-related cysteine peptidase Novel anti-apoptotic microRNAs 582-5p and 363 promote human glioblastoma stem cell survival via direct inhibition of caspase 3, caspase 9, and Bim. 2034 miR-592 hsa-miR-592 MIMAT0003260 miRNA TNFRSF1B apoptosis down Homo sapiens neuronal cell 24573298 9606 7133 CD120b|TBPII|TNF-R-II|TNF-R75|TNFBR|TNFR1B|TNFR2|TNFR80|p75|p75TNFR HGNC:11917|MIM:191191|Ensembl:ENSG00000028137|HPRD:01862|Vega:OTTHUMG00000001829 1 1p36.22 tumor necrosis factor receptor superfamily, member 1B protein-coding tumor necrosis factor receptor superfamily, member 1B After cerebral ischemia, miR-592 levels fall, with a corresponding increase in p75(NTR) levels. Importantly, overexpression of miR-592 in neurons decreases the level of ischemic injury-induced p75(NTR) and attenuates activation of pro-apoptotic signaling and cell death. These results identify miR-592 as a key regulator of p75(NTR) expression and point to a potential therapeutic candidate to limit neuronal apoptosis after ischemic injury. 2035 miR-596 hsa-miR-596 MIMAT0003264 miRNA LGALS3BP apoptosis down Homo sapiens oral squamous cell 23233740 9606 3959 90K|BTBD17B|CyCAP|M2BP|MAC-2-BP|TANGO10B|gp90 HGNC:6564|MIM:600626|Ensembl:ENSG00000108679|HPRD:02796|Vega:OTTHUMG00000177572 17 17q25 lectin, galactoside-binding, soluble, 3 binding protein protein-coding lectin, galactoside-binding, soluble, 3 binding protein The ectopic transfection of double-stranded RNA (dsRNA) mimicking miR-596 or specific small interfering RNA for LGALS3BP significantly induced growth inhibition and apoptosis in cell lines lacking miR-596 expression or overexpressing LGALS3BP, respectively, in a manner associated with a suppression of ERK1/2 phosphorylation. 2036 miR-602 hsa-miR-602 MIMAT0003270 miRNA RB1 apoptosis down Homo sapiens HBV-related hepatoma cells 20364114 9606 5925 OSRC|PPP1R130|RB|p105-Rb|pRb|pp110 HGNC:9884|MIM:614041|Ensembl:ENSG00000139687|HPRD:01574|Vega:OTTHUMG00000016900 13 13q14.2 retinoblastoma 1 protein-coding retinoblastoma 1 WUGSC:H_LUCA12.5|cardiac- MicroRNA-602 plays a pro-carcinogenic role in HBV-related hepatocarcinogenesis by inhibiting RASSF1A. 2037 miR-618 hsa-miR-618 MIMAT0003287 miRNA XIAP apoptosis down Homo sapiens anaplastic thyroid cancer (ATC) cell 25145559 9606 331 API3|BIRC4|IAP-3|ILP1|MIHA|XLP2|hIAP-3|hIAP3 HGNC:592|MIM:300079|Ensembl:ENSG00000101966|HPRD:02094|Vega:OTTHUMG00000022336 X Xq25 X-linked inhibitor of apoptosis protein-coding X-linked inhibitor of apoptosis X-linked inhibitor of apoptosis protein (XIAP) is a major factor in cancer growth and progression. Reduction of XIAP induces apoptosis of anaplastic thyroid cancer (ATC), which accounts for more than 50% of thyroid cancer mortality. MicroRNAs (miRNAs) are short non-coding RNA molecules, which modulate gene expression via interaction with mRNA by binding to the 3'-untranslated region (3'-UTR), playing a critical role in cell proliferation, migration, and invasion. In this study, we recruited the ATC cell line 8305C and normal human thyroid cell Nthy-ori 3-1, aiming to find the miRNA which could regulate XIAP and therefore inhibit the growth and invasion of ATC. We first used quantitative real-time PCR (qPCR) to reveal that XIAP mRNA expression was 4.6¡À0.56 folds (P=0.029) up-regulated in 8305C cells, compared with Nthy-ori 3-1 cells. Then miR-618, predicted to target XIAP directly, was detected 0.24¡À0.06 folds (P=0.019) down-regulated in 8305C cells. Next we used Luciferase assay showing that XIAP was a target gene of miR-618, which could repress the XIAP expression at both mRNA and protein levels. After that, CCK-8 assay was performed to show that over-expression of miR-618 could inhibit the growth of 8305C cells. Finally, we employed transwell method to prove that miR-618 could prevent the invasion and migration of 8305C cells. In conclusion, our collective data showed that over-expression of miR-618 could inhibit ATC cells by targeting XIAP gene. MiR-618 inhibits anaplastic thyroid cancer by repressing XIAP in one ATC cell line. 2038 miR-630 hsa-miR-181a-5p,hsa-miR-181a-3p,hsa-miR-181a-2-3p MIMAT0000256,MIMAT0000270,MIMAT0004558 miRNA BAX apoptosis Homo sapiens non-small cell lung cancer (NSCLC) A549 cells 20145152 9606 581 BCL2L4 HGNC:959|MIM:600040|Ensembl:ENSG00000087088|HPRD:02498|Vega:OTTHUMG00000160476 19 19q13.3-q13.4 BCL2-associated X protein protein-coding BCL2-associated X protein Pre-miR-181a and pre-miR-630 consistently modulated mitochondrial/postmitochondrial steps of the intrinsic pathway of apoptosis, including Bax oligomerization, mitochondrial transmembrane potential dissipation, and the proteolytic maturation of caspase-9 and caspase-3. 2039 miR-630 hsa-miR-181a-5p,hsa-miR-181a-3p,hsa-miR-181a-2-3p MIMAT0000256,MIMAT0000270,MIMAT0004558 miRNA CASP3 apoptosis Homo sapiens non-small cell lung cancer (NSCLC) A549 cells 20145152 9606 836 CPP32|CPP32B|SCA-1 HGNC:1504|MIM:600636|Ensembl:ENSG00000164305|HPRD:02799|Vega:OTTHUMG00000133681 4 4q34 caspase 3, apoptosis-related cysteine peptidase protein-coding caspase 3, apoptosis-related cysteine peptidase Pre-miR-181a and pre-miR-630 consistently modulated mitochondrial/postmitochondrial steps of the intrinsic pathway of apoptosis, including Bax oligomerization, mitochondrial transmembrane potential dissipation, and the proteolytic maturation of caspase-9 and caspase-3. 2040 miR-630 hsa-miR-181a-5p,hsa-miR-181a-3p,hsa-miR-181a-2-3p MIMAT0000256,MIMAT0000270,MIMAT0004558 miRNA CASP9 apoptosis Homo sapiens non-small cell lung cancer (NSCLC) A549 cells 20145152 9606 842 APAF-3|APAF3|ICE-LAP6|MCH6|PPP1R56 HGNC:1511|MIM:602234|Ensembl:ENSG00000132906|HPRD:03756|Vega:OTTHUMG00000002256 1 1p36.21 caspase 9, apoptosis-related cysteine peptidase protein-coding caspase 9, apoptosis-related cysteine peptidase Pre-miR-181a and pre-miR-630 consistently modulated mitochondrial/postmitochondrial steps of the intrinsic pathway of apoptosis, including Bax oligomerization, mitochondrial transmembrane potential dissipation, and the proteolytic maturation of caspase-9 and caspase-3. 2041 miR-630 hsa-miR-630 MIMAT0003299 miRNA CDC7 apoptosis down Homo sapiens lung cancer A549 cell 25255219 9606 8317 CDC7L1|HsCDC7|Hsk1|huCDC7 HGNC:1745|MIM:603311|Ensembl:ENSG00000097046|HPRD:10345|Vega:OTTHUMG00000047810 1 1p22 cell division cycle 7 protein-coding cell division cycle 7 MiR-630 inhibits proliferation by targeting CDC7 kinase, but maintains the apoptotic balance by targeting multiple modulators in human lung cancer A549 cells.. 2042 miR-638 hsa-miR-638 MIMAT0003308 miRNA AKT1 apoptosis down Homo sapiens lung carcinoma A549 cell 21303527 9606 207 AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA HGNC:391|MIM:164730|Ensembl:ENSG00000142208|HPRD:01261|Vega:OTTHUMG00000170795 14 14q32.32 v-akt murine thymoma viral oncogene homolog 1 protein-coding v-akt murine thymoma viral oncogene homolog 1 Our study indicated that bostrycin had a significant inhibitory effect on proliferation of A549 cells. It is possible that upregulation of microRNA-638 and microRNA-923 and downregulation of the PI3K/AKT pathway proteins played a role in induction of cell cycle arrest and apoptosis in bostrycin-treated cells. 2043 miR-638 hsa-miR-638 MIMAT0003308 miRNA PIK3CA apoptosis down Homo sapiens lung carcinoma A549 cell 21303527 9606 5290 CLOVE|CWS5|MCAP|MCM|MCMTC|PI3K|p110-alpha HGNC:8975|MIM:171834|HPRD:01382 3 3q26.3 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha protein-coding phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha Our study indicated that bostrycin had a significant inhibitory effect on proliferation of A549 cells. It is possible that upregulation of microRNA-638 and microRNA-923 and downregulation of the PI3K/AKT pathway proteins played a role in induction of cell cycle arrest and apoptosis in bostrycin-treated cells. 2044 miR-638 hsa-miR-638 MIMAT0003308 miRNA TFAP2A apoptosis up Homo sapiens melanoma cell 25650662 9606 7020 AP-2|AP-2alpha|AP2TF|BOFS|TFAP2 HGNC:11742|MIM:107580|Ensembl:ENSG00000137203|HPRD:00128|Vega:OTTHUMG00000014235 6 6p24 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) protein-coding transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) MRNA expression profiling identified new candidate genes including TP53INP2 as miR-638 targets. Overexpression of TP53INP2 severely attenuated proliferative and invasive capacity of melanoma cells which was reversed by miR-638. Depletion of miR-638 stimulated expression of p53 and p53 downstream target genes and induced apoptosis and autophagy. miR-638 promoter analysis identified the miR-638 target transcription factor associated protein 2¦Á (TFAP2A/AP-2¦Á) as a direct negative regulator of miR-638, suggestive for a double-negative regulatory feedback loop. Taken together, miR-638 supports melanoma progression and suppresses p53-mediated apoptosis pathways, autophagy and expression of the transcriptional repressor TFAP2A/AP-2¦Á. 2045 miR-638 hsa-miR-638 MIMAT0003308 miRNA TP53INP2 apoptosis up Homo sapiens melanoma cell 25650662 9606 58476 C20orf110|DOR|PINH|dJ1181N3.1 HGNC:16104|Ensembl:ENSG00000078804|HPRD:15546|Vega:OTTHUMG00000032310 20 20q11.22 tumor protein p53 inducible nuclear protein 2 protein-coding tumor protein p53 inducible nuclear protein 2 MRNA expression profiling identified new candidate genes including TP53INP2 as miR-638 targets. Overexpression of TP53INP2 severely attenuated proliferative and invasive capacity of melanoma cells which was reversed by miR-638. Depletion of miR-638 stimulated expression of p53 and p53 downstream target genes and induced apoptosis and autophagy. miR-638 promoter analysis identified the miR-638 target transcription factor associated protein 2¦Á (TFAP2A/AP-2¦Á) as a direct negative regulator of miR-638, suggestive for a double-negative regulatory feedback loop. Taken together, miR-638 supports melanoma progression and suppresses p53-mediated apoptosis pathways, autophagy and expression of the transcriptional repressor TFAP2A/AP-2¦Á. 2046 miR-642 hsa-miR-642a-5p,hsa-miR-642a-3p,hsa-miR-642b-5p,hsa-miR-642b-3p MIMAT0003312,MIMAT0020924,MIMAT0022736,MIMAT0018444 miRNA apoptosis Homo sapiens gastric cancer cell 24919435 9606 We predicted the targets of the two miRNAs with TargetScan and classified all the candidate targets with Gene Ontology, which indicated that both miR-300 and miR-642 potentially regulate cellular radiation response by modulating apoptosis, cell cycle regulation and DNA damage and repair pathway-related genes. 2047 miR-645 hsa-miR-645 MIMAT0003315 miRNA IFIT2 apoptosis down Homo sapiens gastric cancer cell 25174799 9606 3433 G10P2|GARG-39|IFI-54|IFI-54K|IFI54|IFIT-2|ISG-54 K|ISG-54K|ISG54|P54|cig42 HGNC:5409|MIM:147040|Ensembl:ENSG00000119922|HPRD:00913|Vega:OTTHUMG00000018707 10 10q23.31 interferon-induced protein with tetratricopeptide repeats 2 protein-coding interferon-induced protein with tetratricopeptide repeats 2 MicroRNA-645, up-regulated in human adencarcinoma of gastric esophageal junction, inhibits apoptosis by targeting tumor suppressor IFIT2. 2048 miR-650 hsa-miR-650 MIMAT0003320 miRNA BAX apoptosis up Homo sapiens lung adenocarcinoma cell 23991130 9606 581 BCL2L4 HGNC:959|MIM:600040|Ensembl:ENSG00000087088|HPRD:02498|Vega:OTTHUMG00000160476 19 19q13.3-q13.4 BCL2-associated X protein protein-coding BCL2-associated X protein Additionally, silencing of miR-650 could enhance the caspase-3-dependent apoptosis, which might be correlated with the decreased ratio of Bcl-2/Bax. Further researches suggested that inhibitor of growth 4 (ING4) was a direct target of miR-650. Downregulated or upregulated ING4 expression could partially rescue the effects of miR-650 inhibitor or mimics in docetaxel-resistant or parental LAD cells. Furthermore, we found that ING4 was upregulated in docetaxel-responding LAD tissues, and its expression was inversely correlated with miR-650. Thus, miR-650 is a novel prognostic marker in LAD and its expression is a potential indicator of chemosensitivity to docetaxel-based chemotherapy regimen. 2049 miR-650 hsa-miR-650 MIMAT0003320 miRNA BCL2 apoptosis down Homo sapiens lung adenocarcinoma cell 23991130 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Additionally, silencing of miR-650 could enhance the caspase-3-dependent apoptosis, which might be correlated with the decreased ratio of Bcl-2/Bax. Further researches suggested that inhibitor of growth 4 (ING4) was a direct target of miR-650. Downregulated or upregulated ING4 expression could partially rescue the effects of miR-650 inhibitor or mimics in docetaxel-resistant or parental LAD cells. Furthermore, we found that ING4 was upregulated in docetaxel-responding LAD tissues, and its expression was inversely correlated with miR-650. Thus, miR-650 is a novel prognostic marker in LAD and its expression is a potential indicator of chemosensitivity to docetaxel-based chemotherapy regimen. 2050 miR-650 hsa-miR-650 MIMAT0003320 miRNA ING4 apoptosis down Homo sapiens lung adenocarcinoma cell 23991130 9606 51147 my036|p29ING4 HGNC:19423|MIM:608524|Ensembl:ENSG00000111653|HPRD:09774|Vega:OTTHUMG00000141274 12 12p13.31 inhibitor of growth family, member 4 protein-coding inhibitor of growth family, member 4 Additionally, silencing of miR-650 could enhance the caspase-3-dependent apoptosis, which might be correlated with the decreased ratio of Bcl-2/Bax. Further researches suggested that inhibitor of growth 4 (ING4) was a direct target of miR-650. Downregulated or upregulated ING4 expression could partially rescue the effects of miR-650 inhibitor or mimics in docetaxel-resistant or parental LAD cells. Furthermore, we found that ING4 was upregulated in docetaxel-responding LAD tissues, and its expression was inversely correlated with miR-650. Thus, miR-650 is a novel prognostic marker in LAD and its expression is a potential indicator of chemosensitivity to docetaxel-based chemotherapy regimen. 2051 miR-652 hsa-miR-652-5p,hsa-miR-652-3p MIMAT0022709,MIMAT0003322 miRNA JAG1 apoptosis Homo sapiens heart cell 25145628 9606 182 AGS|AHD|AWS|CD339|HJ1|JAGL1 HGNC:6188|MIM:601920|Ensembl:ENSG00000101384|HPRD:03562 20 20p12.1-p11.23 jagged 1 protein-coding jagged 1 Inhibition of miR-652 improved cardiac function in TAC mice (fractional shortening:29¡À1% at 4 wk post-TAC compared to 35¡À1% post-treatment) and attenuated cardiac hypertrophy. Improvement in heart function was associated with reduced cardiac fibrosis, less apoptosis and B-type natriuretic peptide gene expression, and preserved angiogenesis. Mechanistically, we identified Jagged1 (a Notch1 ligand) as a novel direct target of miR-652. 2052 miR-663 hsa-miR-663a,hsa-miR-663b MIMAT0003326,MIMAT0005867 miRNA BCL2 apoptosis down Homo sapiens non-small cell lung cancer cell 25301444 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Waltonitone induces apoptosis through mir-663-induced Bcl-2 downregulation in non-small cell lung cancer. 2053 miR-663 hsa-miR-663a,hsa-miR-663b MIMAT0003326,MIMAT0005867 miRNA apoptosis Homo sapiens k-562 cell line 23953123 9606 Over-expression of miR-663 may suppress proliferation of the k-562 cell line in part by enhancing cell apoptosis. 2054 miR-675 hsa-miR-675-5p,hsa-miR-675-3p MIMAT0004284,MIMAT0006790 miRNA MITF apoptosis down Homo sapiens melanogenesis 24335901 9606 4286 CMM8|MI|WS2|WS2A|bHLHe32 HGNC:7105|MIM:156845|Ensembl:ENSG00000187098|HPRD:01138|Vega:OTTHUMG00000149921 3 3p14.2-p14.1 microphthalmia-associated transcription factor protein-coding microphthalmia-associated transcription factor miR-675 mimic reduced apoptosis signal-regulating kinase. Luciferase reporter assay showed a direct binding of miR-675 to 3'-untranslated region of MITF. 2055 miR-7 hsa-miR-7-5p,hsa-miR-7-1-3p,hsa-miR-7-2-3p MIMAT0000252,MIMAT0004553,MIMAT0004554 miRNA XIAP apoptosis down Homo sapiens cervical cancer cell 23742934 9606 331 API3|BIRC4|IAP-3|ILP1|MIHA|XLP2|hIAP-3|hIAP3 HGNC:592|MIM:300079|Ensembl:ENSG00000101966|HPRD:02094|Vega:OTTHUMG00000022336 X Xq25 X-linked inhibitor of apoptosis protein-coding X-linked inhibitor of apoptosis MicroRNA-7 downregulates XIAP expression to suppress cell growth and promote apoptosis in cervical cancer cells. 2056 miR-7 hsa-miR-7-5p,hsa-miR-7-1-3p,hsa-miR-7-2-3p MIMAT0000252,MIMAT0004553,MIMAT0004554 miRNA YY1 apoptosis down Homo sapiens colon cancer cells 23208495 9606 7528 DELTA|INO80S|NF-E1|UCRBP|YIN-YANG-1 HGNC:12856|MIM:600013|HPRD:02482 14 14q YY1 transcription factor protein-coding YY1 transcription factor In conclusion, MiR-7 is a novel miRNA with tumor suppressive function in colon cancer by targeting oncogenic YY1. YY1 promotes colon cancer growth through inhibiting p53 and promoting Wnt signaling pathways and serves as an independent prognostic biomarker for CRC patients. 2057 miR-7 hsa-miR-7-5p,hsa-miR-7-1-3p,hsa-miR-7-2-3p MIMAT0000252,MIMAT0004553,MIMAT0004554 miRNA apoptosis Homo sapiens HeLa cells 15741182 9606 We also identified miRNA that when inhibited increased the level of apoptosis (miR-1d, 7, 148, 204, 210, 216 and 296) and one miRNA that decreased apoptosis (miR-214) in HeLa cells. 2058 miR-708 hsa-miR-708-5p,hsa-miR-708-3p MIMAT0004926,MIMAT0004927 miRNA AKT1 apoptosis down Homo sapiens Glioblastoma cells 23754151 9606 207 AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA HGNC:391|MIM:164730|Ensembl:ENSG00000142208|HPRD:01261|Vega:OTTHUMG00000170795 14 14q32.32 v-akt murine thymoma viral oncogene homolog 1 protein-coding v-akt murine thymoma viral oncogene homolog 1 The overexpression of miR-708 inhibited cell proliferation and invasion and induced apoptosis in the human GBM cell lines A172 and T98G. Furthermore, the overexpression of miR-708 reduced the expression of Akt1, CCND1, MMP2, EZH2, Parp-1 and Bcl2 in A172 and T98G cells. Taken together, 2059 miR-708 hsa-miR-708-5p,hsa-miR-708-3p MIMAT0004926,MIMAT0004927 miRNA BCL2 apoptosis down Homo sapiens Glioblastoma cells 23754151 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 The overexpression of miR-708 inhibited cell proliferation and invasion and induced apoptosis in the human GBM cell lines A172 and T98G. Furthermore, the overexpression of miR-708 reduced the expression of Akt1, CCND1, MMP2, EZH2, Parp-1 and Bcl2 in A172 and T98G cells. Taken together, 2060 miR-708 hsa-miR-708-5p,hsa-miR-708-3p MIMAT0004926,MIMAT0004927 miRNA BIRC5 apoptosis down Homo sapiens renal cancer cells 21852381 9606 332 API4|EPR-1 HGNC:593|MIM:603352|Ensembl:ENSG00000089685|HPRD:04520|Vega:OTTHUMG00000177505 17 17q25 baculoviral IAP repeat containing 5 protein-coding baculoviral IAP repeat containing 5 apoptosis inhibitor 4|apo Investigation of the targets of miR-708 identified the inhibitor of apoptosis protein survivin as important. siRNA-mediated knockdown of survivin partially phenocopied miR-708 overexpression suggesting that the proapoptotic role of miR-708 may be mediated primarily through survivin regulation. Additionally, we identified the E-cadherin regulators ZEB2 and BMI1 as likely miR-708 targets. 2061 miR-708 hsa-miR-708-5p,hsa-miR-708-3p MIMAT0004926,MIMAT0004927 miRNA CCND1 apoptosis down Homo sapiens Glioblastoma cells 23754151 9606 595 BCL1|D11S287E|PRAD1|U21B31 HGNC:1582|MIM:168461|Ensembl:ENSG00000110092|HPRD:01346|Vega:OTTHUMG00000167877 11 11q13 cyclin D1 protein-coding cyclin D1 The overexpression of miR-708 inhibited cell proliferation and invasion and induced apoptosis in the human GBM cell lines A172 and T98G. Furthermore, the overexpression of miR-708 reduced the expression of Akt1, CCND1, MMP2, EZH2, Parp-1 and Bcl2 in A172 and T98G cells. Taken together, 2062 miR-708 hsa-miR-708-5p,hsa-miR-708-3p MIMAT0004926,MIMAT0004927 miRNA EZH2 apoptosis down Homo sapiens Glioblastoma cells 23754151 9606 2146 ENX-1|ENX1|EZH1|EZH2b|KMT6|KMT6A|WVS|WVS2 HGNC:3527|MIM:601573|Ensembl:ENSG00000106462|HPRD:03342|Vega:OTTHUMG00000158973 7 7q35-q36 enhancer of zeste 2 polycomb repressive complex 2 subunit protein-coding enhancer of zeste 2 polycomb repressive complex 2 subunit The overexpression of miR-708 inhibited cell proliferation and invasion and induced apoptosis in the human GBM cell lines A172 and T98G. Furthermore, the overexpression of miR-708 reduced the expression of Akt1, CCND1, MMP2, EZH2, Parp-1 and Bcl2 in A172 and T98G cells. Taken together, 2063 miR-708 hsa-miR-708-5p,hsa-miR-708-3p MIMAT0004926,MIMAT0004927 miRNA MMP2 apoptosis down Homo sapiens Glioblastoma cells 23754151 9606 4313 CLG4|CLG4A|MMP-II|MONA|TBE-1 HGNC:7166|MIM:120360|Ensembl:ENSG00000087245|HPRD:00386|Vega:OTTHUMG00000133202 16 16q13-q21 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) protein-coding matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) The overexpression of miR-708 inhibited cell proliferation and invasion and induced apoptosis in the human GBM cell lines A172 and T98G. Furthermore, the overexpression of miR-708 reduced the expression of Akt1, CCND1, MMP2, EZH2, Parp-1 and Bcl2 in A172 and T98G cells. Taken together, 2064 miR-708 hsa-miR-708-5p,hsa-miR-708-3p MIMAT0004926,MIMAT0004927 miRNA PARP1 apoptosis down Homo sapiens Glioblastoma cells 23754151 9606 142 ADPRT|ADPRT 1|ADPRT1|ARTD1|PARP|PARP-1|PPOL|pADPRT-1 HGNC:270|MIM:173870|Ensembl:ENSG00000143799|HPRD:01435|Vega:OTTHUMG00000037556 1 1q41-q42 poly (ADP-ribose) polymerase 1 protein-coding poly (ADP-ribose) polymerase 1 The overexpression of miR-708 inhibited cell proliferation and invasion and induced apoptosis in the human GBM cell lines A172 and T98G. Furthermore, the overexpression of miR-708 reduced the expression of Akt1, CCND1, MMP2, EZH2, Parp-1 and Bcl2 in A172 and T98G cells. Taken together, 2065 miR-7-1 hsa-miR-7-1-3p MIMAT0004553 miRNA AKT1 apoptosis up Homo sapiens VSC4.1 motoneurons 24157932 9606 207 AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA HGNC:391|MIM:164730|Ensembl:ENSG00000142208|HPRD:01261|Vega:OTTHUMG00000170795 14 14q32.32 v-akt murine thymoma viral oncogene homolog 1 protein-coding v-akt murine thymoma viral oncogene homolog 1 miR-7-1 overexpression and WAY or EST treatment down regulated CP¦Á1C but upregulated p-Akt to trigger cell survival signaling. 2066 miR-7-1 hsa-miR-7-1-3p MIMAT0004553 miRNA BAX apoptosis down Homo sapiens VSC4.1 motoneurons 24157932 9606 581 BCL2L4 HGNC:959|MIM:600040|Ensembl:ENSG00000087088|HPRD:02498|Vega:OTTHUMG00000160476 19 19q13.3-q13.4 BCL2-associated X protein protein-coding BCL2-associated X protein Overexpression of miR-7-1 maximally increased efficacy of WAY and EST for down regulation of pro-apoptotic Bax and upregulation of anti-apoptotic Bcl-2. 2067 miR-7-1 hsa-miR-7-1-3p MIMAT0004553 miRNA BCL2 apoptosis up Homo sapiens VSC4.1 motoneurons 24157932 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Overexpression of miR-7-1 maximally increased efficacy of WAY and EST for down regulation of pro-apoptotic Bax and upregulation of anti-apoptotic Bcl-2. 2068 miR-7-1 hsa-miR-7-1-3p MIMAT0004553 miRNA CACNA1C apoptosis down Homo sapiens VSC4.1 motoneurons 24157932 9606 775 CACH2|CACN2|CACNL1A1|CCHL1A1|CaV1.2|LQT8|TS HGNC:1390|MIM:114205|HPRD:00246 12 12p13.3 calcium channel, voltage-dependent, L type, alpha 1C subunit protein-coding calcium channel, voltage-dependent, L type, alpha 1C subunit A search using microRNA database (miRDB) indicated that miR-7-1 could inhibit the expression of L-type Ca(2+) channel protein alpha 1C (CP¦Á1C). 2069 miR-720 Schopman et al. show that the sequence annotated as miR-720 is likely to be a fragment of a tRNA, and so is removed from the database (RNA Biol. 2010 7:573-578). miRNA BAX apoptosis up Homo sapiens leukemia cell 25417880 9606 581 BCL2L4 HGNC:959|MIM:600040|Ensembl:ENSG00000087088|HPRD:02498|Vega:OTTHUMG00000160476 19 19q13.3-q13.4 BCL2-associated X protein protein-coding BCL2-associated X protein In addition, overexpression of miR-720 significantly induced increased cell apoptosis-related proteins including P53 and Bax, and activation of NF-¦ÊB signal transduction pathway. 2070 miR-720 Schopman et al. show that the sequence annotated as miR-720 is likely to be a fragment of a tRNA, and so is removed from the database (RNA Biol. 2010 7:573-578). miRNA NFKB1 apoptosis Homo sapiens leukemia cell 25417880 9606 4790 EBP-1|KBF1|NF-kB1|NF-kappa-B|NF-kappaB|NFKB-p105|NFKB-p50|NFkappaB|p105|p50 HGNC:7794|MIM:164011|Ensembl:ENSG00000109320|HPRD:01238|Vega:OTTHUMG00000161080 4 4q24 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 protein-coding nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 In addition, overexpression of miR-720 significantly induced increased cell apoptosis-related proteins including P53 and Bax, and activation of NF-¦ÊB signal transduction pathway. 2071 miR-720 Schopman et al. show that the sequence annotated as miR-720 is likely to be a fragment of a tRNA, and so is removed from the database (RNA Biol. 2010 7:573-576). miRNA TP53 apoptosis up Homo sapiens leukemia cell 25417880 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 In addition, overexpression of miR-720 significantly induced increased cell apoptosis-related proteins including P53 and Bax, and activation of NF-¦ÊB signal transduction pathway. 2072 miR-760 hsa-miR-760 MIMAT0004957 miRNA ABCA1 apoptosis Homo sapiens breast cancer cell 25661353 9606 19 ABC-1|ABC1|CERP|HDLDT1|TGD HGNC:29|MIM:600046|Ensembl:ENSG00000165029|HPRD:02501|Vega:OTTHUMG00000020417 9 9q31.1 ATP-binding cassette, sub-family A (ABC1), member 1 protein-coding ATP-binding cassette, sub-family A (ABC1), member 1 GO analysis result appeared that the predicted target genes of miR-760 mainly regulated DNA binding, protein binding, molecular function, nucleic acid binding, and so on; the pathway analysis data demonstrated that these target genes mainly involved in cell cycle, TGF-beta signaling pathway, mRNA processing reactome, G protein signaling, apoptosis, Wnt signaling pathway, and other signaling pathways. There were 3 predicted target genes (RHOB, ANGOTL4, ABCA1) of miR-760 were selected at a P value<0.05 and the fold enrichment was>40. 2073 miR-760 hsa-miR-760 MIMAT0004957 miRNA ANGOTL4 apoptosis Homo sapiens breast cancer cell 25661353 9606 GO analysis result appeared that the predicted target genes of miR-760 mainly regulated DNA binding, protein binding, molecular function, nucleic acid binding, and so on; the pathway analysis data demonstrated that these target genes mainly involved in cell cycle, TGF-beta signaling pathway, mRNA processing reactome, G protein signaling, apoptosis, Wnt signaling pathway, and other signaling pathways. There were 3 predicted target genes (RHOB, ANGOTL4, ABCA1) of miR-760 were selected at a P value<0.05 and the fold enrichment was>40. 2074 miR-760 hsa-miR-760 MIMAT0004957 miRNA RHOB apoptosis Homo sapiens breast cancer cell 25661353 9606 388 ARH6|ARHB|MST081|MSTP081|RHOH6 HGNC:668|MIM:165370|Ensembl:ENSG00000143878|HPRD:01321|Vega:OTTHUMG00000090755 2 2p24 ras homolog family member B protein-coding ras homolog family member B GO analysis result appeared that the predicted target genes of miR-760 mainly regulated DNA binding, protein binding, molecular function, nucleic acid binding, and so on; the pathway analysis data demonstrated that these target genes mainly involved in cell cycle, TGF-beta signaling pathway, mRNA processing reactome, G protein signaling, apoptosis, Wnt signaling pathway, and other signaling pathways. There were 3 predicted target genes (RHOB, ANGOTL4, ABCA1) of miR-760 were selected at a P value<0.05 and the fold enrichment was>40. 2075 miR-761 hsa-miR-761 MIMAT0010364 miRNA MFF apoptosis down Homo sapiens myocardial cell 23867156 9606 56947 C2orf33|GL004 HGNC:24858|MIM:614785|Ensembl:ENSG00000168958|HPRD:16653|Vega:OTTHUMG00000133180 2 2q36.3 mitochondrial fission factor protein-coding mitochondrial fission factor Knockdown of MFF attenuated hydrogen peroxide- and I/R injury-induced cardiomyocyte apoptosis and myocardial infarction. We found that MFF is a direct target of miR-761, and miR-761 inhibits mitochondrial fission and cardiomyocyte apoptosis by repressing MFF. 2076 miR-766 hsa-miR-766-3p,hsa-miR-766-5p MIMAT0003888,MIMAT0022714 miRNA BAX apoptosis down Homo sapiens acute promyelocytic leukemia 24356076 9606 581 BCL2L4 HGNC:959|MIM:600040|Ensembl:ENSG00000087088|HPRD:02498|Vega:OTTHUMG00000160476 19 19q13.3-q13.4 BCL2-associated X protein protein-coding BCL2-associated X protein As2O3 significantly inhibited cell viability and induced apoptosis in APL cells. Several microRNAs, including let-7d and miR-766, were dysregulated in APL cells treated with As2O3.The expression of caspase-3 and Bax, which are targets of let-7d and miR-766, respectively, were up-regulated in As2O3 treated cells. 2077 miR-769-3p hsa-miR-769-3p MIMAT0003887 miRNA NDRG1 apoptosis down Homo sapiens breast cancer MCF-7 cell 25081069 9606 10397 CAP43|CMT4D|DRG-1|DRG1|GC4|HMSNL|NDR1|NMSL|PROXY1|RIT42|RTP|TARG1|TDD5 HGNC:7679|MIM:605262|Ensembl:ENSG00000104419|HPRD:05586|Vega:OTTHUMG00000164441 8 8q24.3 N-myc downstream regulated 1 protein-coding N-myc downstream regulated 1 In particular, miR-769-3p was able to inhibit the expression of NDRG1, which caused a significant reduction of NDRG1 protein upon reoxygenation. Furthermore, overexpression of miR-769-3p significantly inhibited cell proliferation and enhanced apoptosis. Our results revealed that miR-769-3p can functionally regulate NDRG1 during changes in oxygen concentration. 2078 miR-802 hsa-miR-802 MIMAT0004185 miRNA CDKN1B apoptosis down Homo sapiens osteosarcoma 24460254 9606 1027 CDKN4|KIP1|MEN1B|MEN4|P27KIP1 HGNC:1785|MIM:600778|Ensembl:ENSG00000111276|HPRD:02867|Vega:OTTHUMG00000149914 12 12p13.1-p12 cyclin-dependent kinase inhibitor 1B (p27, Kip1) protein-coding cyclin-dependent kinase inhibitor 1B (p27, Kip1) At the molecular level, our results further revealed that expression of p27, a negative cell-cycle regulator, was negatively regulated by miR-802. 2079 miR-874 hsa-miR-874-5p,hsa-miR-874-3p MIMAT0026718,MIMAT0004911 miRNA AQP3 apoptosis up Homo sapiens gastric cancer cells 23800944 9606 360 AQP-3|GIL HGNC:636|MIM:600170|Ensembl:ENSG00000165272|HPRD:08970|Vega:OTTHUMG00000019769 9 9p13 aquaporin 3 (Gill blood group) protein-coding aquaporin 3 (Gill blood group) miR-874 Inhibits cell proliferation, migration and invasion through targeting aquaporin-3 in gastric cancer.Down-regulation of Bcl-2, MT1-MMP, MMP-2 and MMP-9 and upregulation of caspase-3 activity and Bax were involved in miR-874 inducing cell apoptosis, and inhibiting migration and invasion. 2080 miR-874 hsa-miR-874-3p,hsa-miR-874-5p MIMAT0004911,MIMAT0026718 miRNA CDK9 apoptosis down Homo sapiens breast cancer cell 25281924 9606 1025 C-2k|CDC2L4|CTK1|PITALRE|TAK HGNC:1780|MIM:603251|Ensembl:ENSG00000136807|HPRD:16016|Vega:OTTHUMG00000020715 9 9q34.1 cyclin-dependent kinase 9 protein-coding cyclin-dependent kinase 9 It has been demonstrated that miR-874 plays important roles in many types of cancers. Nevertheless, its biological function in breast cancer remains largely unknown. In this study, we found that the expression level of miR-874 is down-regulated in breast cancer in comparison with the adjacent normal tissues. The overexpression of miR-874 is able to inhibit cell proliferation and induce cell apoptosis and cell cycle arrest in MCF7 and MDA-MB-231 cells. Using a bioinformatics method, we further show that CDK9 is a direct target of miR-874 and that its protein level is negatively regulated by miR-874. Therefore, the data reported in this manuscript demonstrate that miR-874 is an important regulator in breast cancer and imply that the miR-874/CDK9 axis has potential as a therapeutic target for breast cancer. 2081 miR-875 hsa-miR-875-5p,hsa-miR-875-3p MIMAT0004922,MIMAT0004923 miRNA PRDX3 apoptosis down Homo sapiens embryonic ventral mesencephalic and neuroblastoma cells 23846856 9606 10935 AOP-1|AOP1|HBC189|MER5|PRO1748|SP-22|prx-III HGNC:9354|MIM:604769|Ensembl:ENSG00000165672|HPRD:05305|Vega:OTTHUMG00000019146 10 10q25-q26 peroxiredoxin 3 protein-coding peroxiredoxin 3 we confirmed that Prx III was a direct target gene of miR-875. Taken together, these findings demonstrate that changes in miRNA expression occur after 6-OHDA treatment and suggest that miRNAs and their predicted targets have a potential role in apoptosis of MN9D cells. 2082 miR-885-3p hsa-miR-885-3p MIMAT0004948 miRNA BCL2 apoptosis down Homo sapiens 22071691 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 The p-¦¤Np63¦Á-induced miR-885-3p functions as a critical regulator of MDM4, ATK1, BCL2, ATG16L2, ULK2, CASP2 and CASP3 mRNAs via pairing with their respective ¡°recognition¡± sequences. Altogether, our results support the notion that miR-885-3p might contribute in regulation of cell viability, apoptosis and/or autophagy in squamous cell carcinoma cells upon cisplatin exposure. 2083 miR-885-3p hsa-miR-885-3p MIMAT0004948 miRNA CASP2 apoptosis up Homo sapiens 22071691 9606 835 CASP-2|ICH1|NEDD-2|NEDD2|PPP1R57 HGNC:1503|MIM:600639|Ensembl:ENSG00000106144|HPRD:02800|Vega:OTTHUMG00000023641 7 7q34-q35 caspase 2, apoptosis-related cysteine peptidase protein-coding caspase 2, apoptosis-related cysteine peptidase The p-¦¤Np63¦Á-induced miR-885-3p functions as a critical regulator of MDM4, ATK1, BCL2, ATG16L2, ULK2, CASP2 and CASP3 mRNAs via pairing with their respective ¡°recognition¡± sequences. Altogether, our results support the notion that miR-885-3p might contribute in regulation of cell viability, apoptosis and/or autophagy in squamous cell carcinoma cells upon cisplatin exposure. 2084 miR-885-3p hsa-miR-885-3p MIMAT0004948 miRNA CASP3 apoptosis up Homo sapiens 22071691 9606 836 CPP32|CPP32B|SCA-1 HGNC:1504|MIM:600636|Ensembl:ENSG00000164305|HPRD:02799|Vega:OTTHUMG00000133681 4 4q34 caspase 3, apoptosis-related cysteine peptidase protein-coding caspase 3, apoptosis-related cysteine peptidase The p-¦¤Np63¦Á-induced miR-885-3p functions as a critical regulator of MDM4, ATK1, BCL2, ATG16L2, ULK2, CASP2 and CASP3 mRNAs via pairing with their respective ¡°recognition¡± sequences. Altogether, our results support the notion that miR-885-3p might contribute in regulation of cell viability, apoptosis and/or autophagy in squamous cell carcinoma cells upon cisplatin exposure. 2085 miR-885-5p hsa-miR-885-5p MIMAT0004947 miRNA EPO apoptosis Homo sapiens Neuron-Like cell 25324845 9606 2056 EP|MVCD2 HGNC:3415|MIM:133170|Ensembl:ENSG00000130427|HPRD:00586|Vega:OTTHUMG00000152121 7 7q22 erythropoietin protein-coding erythropoietin Accordingly, target prediction and transcriptome analysis of cells treated with EPO revealed an alteration of the expression of genes involved in apoptosis, cell survival, proliferation, and migration.In this study, we report for the first time that EPO downregulates the expression of miRNAs (miR-451 and miR-885-5p) in SH-SY5Y neuronal-like cells. The correlation between the over-expression of miRNAs and the decrease in EPO-mediated biological effects suggests that miR-451 and miR-885-5p may play a key role in the mediation of biological function. 2086 miR-886-5p hsa-miR-885-5p MIMAT0004947 miRNA BAX apoptosis down Homo sapiens cervical carcinoma cell 20947150 9606 581 BCL2L4 HGNC:959|MIM:600040|Ensembl:ENSG00000087088|HPRD:02498|Vega:OTTHUMG00000160476 19 19q13.3-q13.4 BCL2-associated X protein protein-coding BCL2-associated X protein MicroRNA miR-886-5p inhibits apoptosis by down-regulating Bax expression in human cervical carcinoma cells. 2087 miR-9 hsa-miR-9-5p,hsa-miR-9-3p MIMAT0000441,MIMAT0000442 miRNA DDIT3 apoptosis up Homo sapiens ARPE-19 cell 20806079 9606 1649 CEBPZ|CHOP|CHOP-10|CHOP10|GADD153 HGNC:2726|MIM:126337|Ensembl:ENSG00000175197|HPRD:00529|Vega:OTTHUMG00000170046 12 12q13.1-q13.2 DNA-damage-inducible transcript 3 protein-coding DNA-damage-inducible transcript 3 Treatment of ARPE-19 cells with 4HPR resulted in apoptosis characterized by the increased expression of HMOX1 and GADD153 genes. A twofold increase in the expression of miR-9 was also observed during this response. 2088 miR-9 hsa-miR-9-5p,hsa-miR-9-3p MIMAT0000441,MIMAT0000442 miRNA HMOX1 apoptosis up Homo sapiens ARPE-19 cell 20806079 9606 3162 HMOX1D|HO-1|HSP32|bK286B10 HGNC:5013|MIM:141250|Ensembl:ENSG00000100292|HPRD:00782|Vega:OTTHUMG00000150960 22 22q13.1 heme oxygenase (decycling) 1 protein-coding heme oxygenase (decycling) 1 Treatment of ARPE-19 cells with 4HPR resulted in apoptosis characterized by the increased expression of HMOX1 and GADD153 genes. A twofold increase in the expression of miR-9 was also observed during this response. 2089 miR-9 hsa-miR-9-5p,hsa-miR-9-3p MIMAT0000441,MIMAT0000442 miRNA MALAT1 apoptosis down Homo sapiens osteosarcoma cell 25592968 9606 378938 HCN|LINC00047|MALAT-1|NCRNA00047|NEAT2|PRO2853|mascRNA HGNC:29665|MIM:607924|Ensembl:ENSG00000251562 11 11q13.1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) ncRNA metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) 17¦Â-Estradiol regulates cell proliferation, colony formation, migration, invasion and promotes apoptosis by upregulating miR-9 and thus degrades MALAT-1 in osteosarcoma cell MG-63 in an estrogen receptor-independent manner. 2090 miR-9 hsa-miR-9-5p,hsa-miR-9-3p MIMAT0000441,MIMAT0000442 miRNA MECOM apoptosis down Homo sapiens hematopoietic cells 23509296 9606 2122 AML1-EVI-1|EVI1|MDS1|MDS1-EVI1|PRDM3 HGNC:3498|MIM:165215|Ensembl:ENSG00000085276|HPRD:01310|Vega:OTTHUMG00000158596 3 3q26.2 MDS1 and EVI1 complex locus protein-coding MDS1 and EVI1 complex locus Here we show that EVI1 binds to the promoter of miR-9-3, leading to DNA hypermethylation of the promoter and repression of miR-9. 2091 miR-92 hsa-miR-92a-1-5p,hsa-miR-92a-2-5p,hsa-miR-92a-3p,hsa-miR-92b-5p,hsa-miR-92b-3p MIMAT0004507,MIMAT0004508,MIMAT0000092,MIMAT0004792,MIMAT0003218 miRNA BCL2L11 apoptosis Homo sapiens stem cell 25184675 9606 10018 BAM|BIM|BOD HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 2 2q13 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) Moreover, we found that three miRNA families, miR-20, miR-92, and miR-302, control the mitochondrial apoptotic machinery by fine-tuning the levels of expression of the proapoptotic protein BIM. 2092 miR-92 hsa-miR-92a-1-5p,hsa-miR-92a-3p,hsa-miR-92a-2-5p¨Ûhsa-miR-92b-5p¨Ûhsa- MIMAT0004507,MIMAT0000092,MIMAT0004508¨ÛMIMAT00047 miRNA apoptosis up Homo sapiens CD4(+)T cells 23681423 9606 8503 p55|p55-GAMMA HGNC:8981|Ensembl:ENSG00000117461|HPRD:05831|MIM:606076|Vega:OTTHUMG00000008096 1 1p34.1 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) protein coding phosphoinositide-3-kinase, regulatory subunit 3 (gamma) miR-17-92 cluster: an apoptosis inducer or proliferation enhancer.In silico investigations revealed that the suggested miRNAs targeted genes that were involved in cell proliferation, survival, and apoptosis. Transcriptional analysis of PIK3R3 illustrated decrease in activated cells relative to IL-2 induced cells. According to our findings, it seems that multiple members of miR-17-92 families in activated CD4(+)T cells inhibited negative regulators of IL-2 such as DUSP, PTPN, and SOCS families after IL-2 induction. 2093 miR-92-1 hsa-miR-92a-1-5p,hsa-miR-92a-1-3p MIMAT0004507,MIMAT0000092 miRNA BCL2L11 apoptosis down Homo sapiens macrophages 24583285 9606 10018 BAM|BIM|BOD HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 2 2q13 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) Database analysis of miR-17-92 miRNAs revealed the potential binding sites in the 3'UTR of Bim, one of the crucial effectors of pro-apoptosis. 2094 miR-92-1 hsa-miR-92a-1-5p,hsa-miR-92a-1-3p MIMAT0004507,MIMAT0000092 miRNA E2F1 apoptosis down Homo sapiens leukemic T-cell 19148830 9606 1869 E2F-1|RBAP1|RBBP3|RBP3 HGNC:3113|MIM:189971|Ensembl:ENSG00000101412|HPRD:01806|Vega:OTTHUMG00000032265 20 20q11.2 E2F transcription factor 1 protein-coding E2F transcription factor 1 The pri-miR-17-92 polycistron encodes micro-RNAs (miRNAs), which decrease E2F1 protein expression, regulating proliferation and/or apoptosis. Quantification of pri-miR-17-92 in T-ALL cell lines suggested an implication of the NK-like homeodomain proteins in transcriptional regulation. Lentiviral-mediated overexpression of NKX2-5 in the T-ALL cell line MOLT-4 consistently resulted in increased miR-17-92 pri-miRNA levels and decreased amounts of E2F1 protein. Induction of apoptosis by treating miR17-92 or E2F1 transduced T-ALL cells with etoposide led to reduced or enhanced cell viability, respectively. 2095 miR-92-1 hsa-miR-92a-1-5p,hsa-miR-92a-1-3p MIMAT0004507,MIMAT0000092 miRNA PTEN apoptosis down Homo sapiens 20851997 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog Taken together with previous reports that miR-17-92 inhibits apoptosis by suppressing Pten via the miR-19 components, our results indicate that this miRNA cluster promotes tumorigenesis by antagonizing both tumor-suppressing mechanisms, apoptosis, and senescence, through the activities of different miRNA components encoded in this cluster. 2096 miR-92-1 hsa-miR-92a-1-5p,hsa-miR-92a-1-3p MIMAT0004507,MIMAT0000092 miRNA apoptosis Homo sapiens 20008931 9606 By using a conditional knockout allele of miR-17 approximately 92, we show here that sustained expression of endogenous miR-17 approximately 92 is required to suppress apoptosis in Myc-driven B-cell lymphomas. 2097 miR-923 Human mir-923 appears to be a frgament of the 28S rRNA, so is removed from the database miRNA AKT1 apoptosis down Homo sapiens lung carcinoma A549 cell 21303527 9606 207 AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA HGNC:391|MIM:164730|Ensembl:ENSG00000142208|HPRD:01261|Vega:OTTHUMG00000170795 14 14q32.32 v-akt murine thymoma viral oncogene homolog 1 protein-coding v-akt murine thymoma viral oncogene homolog 1 Our study indicated that bostrycin had a significant inhibitory effect on proliferation of A549 cells. It is possible that upregulation of microRNA-638 and microRNA-923 and downregulation of the PI3K/AKT pathway proteins played a role in induction of cell cycle arrest and apoptosis in bostrycin-treated cells. 2098 miR-923 Human mir-923 appears to be a frgament of the 28S rRNA, so is removed from the database miRNA PIK3CA apoptosis down Homo sapiens lung carcinoma A549 cell 21303527 9606 5290 CLOVE|CWS5|MCAP|MCM|MCMTC|PI3K|p110-alpha HGNC:8975|MIM:171834|HPRD:01382 3 3q26.3 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha protein-coding phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha Our study indicated that bostrycin had a significant inhibitory effect on proliferation of A549 cells. It is possible that upregulation of microRNA-638 and microRNA-923 and downregulation of the PI3K/AKT pathway proteins played a role in induction of cell cycle arrest and apoptosis in bostrycin-treated cells. 2099 miR-92a hsa-miR-92a-3p,hsa-miR-92a-1-5p,hsa-miR-92a-2-5p MIMAT0000092,MIMAT0004507,MIMAT0004508 miRNA BCL2L11 apoptosis down Homo sapiens glioma cells 22895567 9606 10018 BAM|BIM|BOD HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 2 2q13 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) Here, we present the first evidence that miR-92a antisense oligonucleotide (AS-miR-92a) provides a tumor suppressive effect via induction of apoptosis in human glioma cells. 2100 miR-93 hsa-miR-93-5p,hsa-miR-93-3p MIMAT0000093,MIMAT0004509 miRNA BCL2L11 apoptosis down Homo sapiens gastric cancer cells 18328430 9606 10018 BAM|BIM|BOD HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 2 2q13 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) Here we provide evidence that the miR-106b-25 cluster, upregulated in a subset of human gastric tumors, is activated by E2F1 in parallel with its host gene, Mcm7. In turn, miR-106b and miR-93 regulate E2F1 expression, establishing a miRNA-directed negative feedback loop. Furthermore, upregulation of these miRNAs impairs the TGFbeta tumor suppressor pathway, interfering with the expression of CDKN1A (p21(Waf1/Cip1)) and BCL2L11 (Bim). 2101 miR-93 hsa-miR-93-5p,hsa-miR-93-3p MIMAT0000093 ,MIMAT0004509 miRNA BGLT3 apoptosis Homo sapiens myeloid leukemia 24837367 9606 103344929 BGL3|LINC01083|lncRNA-BGL3 HGNC:49033 11 11p15.4 beta globin locus transcript 3 (non-protein coding) ncRNA beta globin locus transcript 3 (non-protein coding) We identified that lncRNA-BGL3 was a target of miR-17,miR-93, miR-20a, miR-20b, miR-106a and miR-106b, microRNAs that repress mRNA of phosphatase and tensin homolog (PTEN). Further experiments demonstrated that lncRNA-BGL3 functioned as a competitive endogenous RNA for binding these microRNAs to cross-regulate PTEN expression. 2102 miR-93 hsa-miR-93-5p,hsa-miR-93-3p MIMAT0000093,MIMAT0004509 miRNA CDKN1A apoptosis down Homo sapiens gastric cancer cells 18328430 9606 1026 CAP20|CDKN1|CIP1|MDA-6|P21|SDI1|WAF1|p21CIP1 HGNC:1784|MIM:116899|Ensembl:ENSG00000124762|HPRD:00298|Vega:OTTHUMG00000014603 6 6p21.2 cyclin-dependent kinase inhibitor 1A (p21, Cip1) protein-coding cyclin-dependent kinase inhibitor 1A (p21, Cip1) CDK-interacting protein 1 Here we provide evidence that the miR-106b-25 cluster, upregulated in a subset of human gastric tumors, is activated by E2F1 in parallel with its host gene, Mcm7. In turn, miR-106b and miR-93 regulate E2F1 expression, establishing a miRNA-directed negative feedback loop. Furthermore, upregulation of these miRNAs impairs the TGFbeta tumor suppressor pathway, interfering with the expression of CDKN1A (p21(Waf1/Cip1)) and BCL2L11 (Bim). 2103 miR-93 hsa-miR-93-5p,hsa-miR-93-3p MIMAT0000093 ,MIMAT0004509 miRNA E2F1 apoptosis down Homo sapiens gastric cancer cells 18328430 9606 1869 E2F-1|RBAP1|RBBP3|RBP3 HGNC:3113|MIM:189971|Ensembl:ENSG00000101412|HPRD:01806|Vega:OTTHUMG00000032265 20 20q11.2 E2F transcription factor 1 protein-coding E2F transcription factor 1 Here we provide evidence that the miR-106b-25 cluster, upregulated in a subset of human gastric tumors, is activated by E2F1 in parallel with its host gene, Mcm7. In turn, miR-106b and miR-93 regulate E2F1 expression, establishing a miRNA-directed negative feedback loop. Furthermore, upregulation of these miRNAs impairs the TGFbeta tumor suppressor pathway, interfering with the expression of CDKN1A (p21(Waf1/Cip1)) and BCL2L11 (Bim). 2104 miR-93 hsa-miR-93-5p,hsa-miR-93-3p MIMAT0000093 ,MIMAT0004509 miRNA PTEN apoptosis Homo sapiens myeloid leukemia 24837367 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog We identified that lncRNA-BGL3 was a target of miR-17,miR-93, miR-20a, miR-20b, miR-106a and miR-106b, microRNAs that repress mRNA of phosphatase and tensin homolog (PTEN). Further experiments demonstrated that lncRNA-BGL3 functioned as a competitive endogenous RNA for binding these microRNAs to cross-regulate PTEN expression. 2105 miR-93 hsa-miR-93-5p,hsa-miR-93-3p MIMAT0000093 ,MIMAT0004509 miRNA TP53INP1 apoptosis up Homo sapiens HTLV-1-infected/transformed cell 18974142 9606 94241 SIP|TP53DINP1|TP53INP1A|TP53INP1B|Teap|p53DINP1 HGNC:18022|MIM:606185|Ensembl:ENSG00000164938|HPRD:09367|Vega:OTTHUMG00000164697 8 8q22 tumor protein p53 inducible nuclear protein 1 protein-coding tumor protein p53 inducible nuclear protein 1 Additionally, when antagomirs were used to knock down miR-93 and miR-130b in these cells, the expression of TP53INP1 was increased, suggesting that the latter is regulated inside cells by the former. A role for TP53INP1 in regulating cell growth was established by experiments that showed that enhanced TP53INP1 expression increased apoptosis. Collectively, the findings implicate a miR-93/miR-130b-TP53INP1 axis that affects the proliferation and survival of HTLV-1-infected/transformed cells. 2106 miR-93 hsa-miR-93-5p,hsa-miR-93-3p MIMAT0000093 ,MIMAT0004509 miRNA apoptosis Homo sapiens uterine cell 24706045 9606 Mounting evidence supports a functional role for miRNA as either indirect or direct regulators of gene expression which impacts the pathobiology of uterine fibroids. Specifically, miRNAs let-7, 200a, 200c, 93, 106b and 21 have been implicated in cellular proliferation, apoptosis, extracellular matrix turnover, angiogenesis and inflammation. Preliminary data provide evidence to suggest that respective in vitro miRNA expression in leiomyomata and myometrium is regulated by sex steroids. 2107 miR-93 hsa-miR-93-5p,hsa-miR-93-3p MIMAT0000093 ,MIMAT0004509 miRNA apoptosis Homo sapiens glioma cell 24721397 9606 MicroRNA-93 was aberrantly over-expressed in glioma tissues and cell lines. Transient transfection of microRNA-93 mimic led to increased proliferation, G1-to-S cell cycle progression and reduced apoptosis in A172 glioma cells, indicating that micro-RNA-93 might be a new target for the diagnosis and treatment of glioma. 2108 miR-939 hsa-miR-939-5p,hsa-miR-939-3p MIMAT0004982,MIMAT0022939 miRNA HSPB1 apoptosis down Homo sapiens 25655337 9606 3315 CMT2F|HEL-S-102|HMN2B|HS.76067|HSP27|HSP28|Hsp25|SRP27 HGNC:5246|MIM:602195|Ensembl:ENSG00000106211|HPRD:09076|Vega:OTTHUMG00000023228 7 7q11.23 heat shock 27kDa protein 1 protein-coding heat shock 27kDa protein 1 The decreased expressions of HSP27, Brn3a along with elevated levels of hsa-miR-939 are selectively associated with anti-ENA(+) patients and HSP27 was observed to be inversely associated with apoptosis. 2109 miR-939 hsa-miR-939-5p,hsa-miR-939-3p MIMAT0004982,MIMAT0022939 miRNA POU4F1 apoptosis down Homo sapiens 25655337 9606 5457 BRN3A|Oct-T1|RDC-1|brn-3A HGNC:9218|MIM:601632|Ensembl:ENSG00000152192|HPRD:03379|Vega:OTTHUMG00000017119 13 13q31.1 POU class 4 homeobox 1 protein-coding POU class 4 homeobox 1 The decreased expressions of HSP27, Brn3a along with elevated levels of hsa-miR-939 are selectively associated with anti-ENA(+) patients and HSP27 was observed to be inversely associated with apoptosis. 2110 miR-940 hsa-miR-940 MIMAT0004983 miRNA NES apoptosis down Homo sapiens head/neck cell 25118937 9606 10763 - HGNC:7756|MIM:600915|Ensembl:ENSG00000132688|HPRD:09020|Vega:OTTHUMG00000034299 1 1q23.1 nestin protein-coding nestin We further show that miR-940 directly binds to the 3'-untranslated regions of Nestin mRNA and promotes its degradation. Likewise, depletion of Nestin inhibits tumor cell proliferation, arrest cells at G2/M, induces apoptosis and suppresses xenograft tumor formation in vivo. These functions of miR-940 can be reversed by ectopic expression of Nestin, suggesting that miR-940 regulates cell proliferation and survival through Nestin. 2111 miR-942 hsa-miR-942-5p,hsa-miR-942-3p MIMAT0004985,MIMAT0026734 miRNA IFI27 apoptosis down Homo sapiens 24727952 9606 3429 FAM14D|ISG12|ISG12A|P27 HGNC:5397|MIM:600009|Ensembl:ENSG00000165949|HPRD:02479|Vega:OTTHUMG00000171303 14 14q32 interferon, alpha-inducible protein 27 protein-coding interferon, alpha-inducible protein 27 HCV infection decreased miR-942 expression in HLCZ01 cells and miR-942 was inversely correlated with ISG12a expression in both HCV-infected cells and liver biopsies. MiR-942 forced expression in HLCZ01 cells decreased ISG12a expression and subsequently suppressed apoptosis triggered by HCV infection. 2112 miR-942 hsa-miR-942-5p,hsa-miR-942-3p MIMAT0004985,MIMAT0026734 miRNA IFI27 apoptosis down Homo sapiens HCC/gastric cancer cell 24970806 9606 3429 FAM14D|ISG12|ISG12A|P27 HGNC:5397|MIM:600009|Ensembl:ENSG00000165949|HPRD:02479|Vega:OTTHUMG00000171303 14 14q32 interferon, alpha-inducible protein 27 protein-coding interferon, alpha-inducible protein 27 MiR-942 decreases TRAIL-induced apoptosis through ISG12a downregulation and is regulated by AKT.. 2113 miR-96 hsa-miR-96-5p,hsa-miR-96-3p MIMAT0000095,MIMAT0004510 miRNA CPEB1 apoptosis down Homo sapiens gliomas cell 23252827 9606 64506 CEBP|CPE-BP1|CPEB|CPEB-1|hCPEB-1 HGNC:21744|MIM:607342|Ensembl:ENSG00000214575|HPRD:09553|Vega:OTTHUMG00000172877 15 15q25.2 cytoplasmic polyadenylation element binding protein 1 protein-coding cytoplasmic polyadenylation element binding protein 1 Inhibition of the miR-183/96/182 cluster induced ROS-mediated AKT/survival independent of three target genes FGF9, CPEB1, and FOXO1, and inhibition of the miRNA cluster induced p53/apoptosis signaling, which was dependent on these same genes. 2114 miR-96 hsa-miR-96-5p,hsa-miR-96-3p MIMAT0000095,MIMAT0004510 miRNA FGF9 apoptosis down Homo sapiens gliomas cell 23252827 9606 2254 FGF-9|GAF|HBFG-9|HBGF-9|SYNS3 HGNC:3687|MIM:600921|Ensembl:ENSG00000102678|HPRD:02951|Vega:OTTHUMG00000017412 13 13q11-q12 fibroblast growth factor 9 protein-coding fibroblast growth factor 9 Inhibition of the miR-183/96/182 cluster induced ROS-mediated AKT/survival independent of three target genes FGF9, CPEB1, and FOXO1, and inhibition of the miRNA cluster induced p53/apoptosis signaling, which was dependent on these same genes. 2115 miR-96 hsa-miR-96-5p,hsa-miR-96-3p MIMAT0000095,MIMAT0004510 miRNA FOXO1 apoptosis down Homo sapiens gliomas cell 23252827 9606 2308 FKH1|FKHR|FOXO1A HGNC:3819|MIM:136533|Ensembl:ENSG00000150907|HPRD:00645|Vega:OTTHUMG00000016775 13 13q14.1 forkhead box O1 protein-coding forkhead box O1 Inhibition of the miR-183/96/182 cluster induced ROS-mediated AKT/survival independent of three target genes FGF9, CPEB1, and FOXO1, and inhibition of the miRNA cluster induced p53/apoptosis signaling, which was dependent on these same genes. 2116 miR-96 hsa-miR-96-5p,hsa-miR-96-3p MIMAT0000095,MIMAT0004510 miRNA FOXO1 apoptosis up Homo sapiens 24509821 9606 2308 FKH1|FKHR|FOXO1A HGNC:3819|MIM:136533|Ensembl:ENSG00000150907|HPRD:00645|Vega:OTTHUMG00000016775 13 13q14.1 forkhead box O1 protein-coding forkhead box O1 Compound 1 selectively inhibits biogenesis of microRNA-96, upregulating a protein target (FOXO1) and inducing apoptosis in cancer cells. 2117 miR-99a hsa-miR-99a-5p,hsa-miR-99a-3p MIMAT0000097,hsa-miR-99a-3p miRNA CDKN2B-AS1 apoptosis down Homo sapiens gastric 25504755 9606 100048912 ANRIL|CDKN2B-AS|CDKN2BAS|NCRNA00089|PCAT12|p15AS HGNC:34341|MIM:613149|Ensembl:ENSG00000240498 9 9p21.3 CDKN2B antisense RNA 1 ncRNA CDKN2B antisense RNA 1 Our previous study showed that ANRIL was significantly upregulated in gastric cancer, and it could promote cell proliferation and inhibit cell apoptosis by silencing of miR99a and miR449a transcription. 2118 miR-BART15-3p(EBV) ebv-miR-BART15 MIMAT0003713 miRNA BIRC6 apoptosis down Homo sapiens EBV-infected cell 23678170 9606 57448 APOLLON|BRUCE HGNC:13516|MIM:605638|Ensembl:ENSG00000115760|HPRD:05731|Vega:OTTHUMG00000150528 2 2p22.3 baculoviral IAP repeat containing 6 protein-coding baculoviral IAP repeat containing 6 Using bioinformatic analyses, we predicted that miR-BART15-3p may target the antiapoptotic B-cell lymphoma 2 (BCL2), BCL2L2, DEAD (Asp-Glu-Ala-Asp) box polypeptide 42 (DDX42), and baculovirus inhibitor of apoptosis repeat-containing ubiquitin-conjugating enzyme (BRUCE) mRNAs. The luciferase reporter assay showed that only the 3' untranslated region (UTR) of BRUCE was affected by miR-BART15-3p. 2119 miR-BART20-5p(EBV) ebv-miR-BART20-5p MIMAT0003719 miRNA BAD apoptosis down Homo sapiens EBV-associated gastric carcinoma cell 25449437 9606 572 BBC2|BCL2L8 HGNC:936|MIM:603167|Ensembl:ENSG00000002330|HPRD:04409|Vega:OTTHUMG00000134302 11 11q13.1 BCL2-associated agonist of cell death protein-coding BCL2-associated agonist of cell death The expression of BAD mRNA and protein was decreased by miR-BART20-5p and increased by an inhibitor of miR-BART20-5p. PE-Annexin V staining and cell proliferation assays showed that miR-BART20-5p reduced apoptosis and enhanced cell growth. Furthermore, miR-BART20-5p increased chemoresistance to 5-fluorouracil and docetaxel. Our data suggest that miR-BART20-5p contributes to tumorigenesis of EBV-associated gastric carcinoma by directly targeting the 3'-UTR of BAD. 2120 miR-BART4-5p ebv-miR-BART4-5p MIMAT0003412 miRNA BID apoptosis Homo sapiens EBV-negative cell 25740983 9606 637 FP497 HGNC:1050|MIM:601997|Ensembl:ENSG00000015475|HPRD:03590|Vega:OTTHUMG00000150087 22 22q11.1 BH3 interacting domain death agonist protein-coding BH3 interacting domain death agonist Transfection of an ebv-miR-BART4-5p mimic reduced Bid expression in EBV-negative cell lines leading to reduced apoptosis under serum-deprivation. I 2121 miR-BART5(EBV) ebv-miR-BART5 MIMAT0003413 miRNA BBC3 apoptosis down Homo sapiens EBV-nasopharyngeal carcinoma cells 18838543 9606 27113 JFY-1|JFY1|PUMA HGNC:17868|MIM:605854|Ensembl:ENSG00000105327|HPRD:16165|Vega:OTTHUMG00000183489 19 19q13.3-q13.4 BCL2 binding component 3 protein-coding BCL2 binding component 3 bcl-2-binding component 3 Apoptosis can be triggered by depleting miR-BART5 or inducing the expression of PUMA. 2122 miR-K12-1(KSHV) kshv-miR-K12-1-5p,kshv-miR-K12-1-3p MIMAT0002182,MIMAT0015214 miRNA NFKB1 apoptosis Homo sapiens endothelial cell 25010828 9606 4790 EBP-1|KBF1|NF-kB1|NF-kappa-B|NF-kappaB|NFKB-p105|NFKB-p50|NFkappaB|p105|p50 HGNC:7794|MIM:164011|Ensembl:ENSG00000109320|HPRD:01238|Vega:OTTHUMG00000161080 4 4q24 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 protein-coding nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 We have recently reported that targeting SphK2 induces apoptosis for human primary effusion lymphoma (PEL) cell lines infected by the Kaposi's sarcoma associated herpesvirus (KSHV), and this occurs in part through inhibition of canonical NF-¦ÊB activation. 2123 miR-K12-10(KSHV) kshv-miR-K12-10a-5p,kshv-miR-K12-10a-3p MIMAT0015212,MIMAT0002179 miRNA TGFBR2 apoptosis down Homo sapiens primary effusion lymphoma cells 22915806 9606 7048 AAT3|FAA3|LDS1B|LDS2|LDS2B|MFS2|RIIC|TAAD2|TGFR-2|TGFbeta-RII HGNC:11773|MIM:190182|Ensembl:ENSG00000163513|HPRD:01823|Vega:OTTHUMG00000130569 3 3p22 transforming growth factor, beta receptor II (70/80kDa) protein-coding transforming growth factor, beta receptor II (70/80kDa) KSHV miR-K10 variants inhibit TGF-¦Â signaling by targeting TGF-¦Â type II receptor (T¦ÂRII). Computational and reporter mutagenesis analyses identified three functional target sites in the T¦ÂRII 3' untranslated region (3'UTR). Expression of miR-K10 variants is sufficient to inhibit TGF-¦Â induced cell apoptosis. A suppressor of the miRs sensitizes latent KSHV-infected PEL cells to TGF-¦Â and induces apoptosis. 2124 miR-K12-10(KSHV) kshv-miR-K12-10a-5p,kshv-miR-K12-10a-3p MIMAT0015212,MIMAT0002179 miRNA TNFRSF12A apoptosis down Homo sapiens endothelial cell 20844036 9606 51330 CD266|FN14|TWEAKR HGNC:18152|MIM:605914|Ensembl:ENSG00000006327|HPRD:05801|Vega:OTTHUMG00000129001 16 16p13.3 tumor necrosis factor receptor superfamily, member 12A protein-coding tumor necrosis factor receptor superfamily, member 12A In a KS tumor-derived endothelial cell line, the downregulation of TWEAKR by miR-K10a resulted in reduced levels of TWEAK-induced caspase activation. In addition, cells transfected with miR-K10a showed less induction of apoptosis by annexin V staining and terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling (TUNEL) assays. 2125 miR-UL148D(HCMV) hcmv-miR-UL148D MIMAT0001578 miRNA ANP32A apoptosis Homo sapiens 24737391 9606 8125 C15orf1|HPPCn|I1PP2A|LANP|MAPM|PHAP1|PHAPI|PP32 HGNC:13233|MIM:600832|Ensembl:ENSG00000140350|HPRD:09014|Vega:OTTHUMG00000154502 15 15q23 acidic (leucine-rich) nuclear phosphoprotein 32 family, member A protein-coding acidic (leucine-rich) nuclear phosphoprotein 32 family, member A The proapoptotic genes MOAP1, PHAP, and ERN1 are identified to be the potential targets for the miR-UL70-3p and UL148D, respectively. The ERN1 gene plays a role in the initiation of Endoplasmic reticulum stress-induced apoptosis as well as autophagosome formation. This study shows that HCMV employs its miRNA repertoire for countering the cellular apoptosis and autophagy, particularly the mitochondrial-dependent intrinsic pathway of apoptosis. 2126 miR-UL148D(HCMV) hcmv-miR-UL148D MIMAT0001578 miRNA ERN1 apoptosis Homo sapiens 24737391 9606 2081 IRE1|IRE1P|IRE1a|hIRE1p HGNC:3449|MIM:604033|Ensembl:ENSG00000178607|HPRD:04943|Vega:OTTHUMG00000178879 17 17q24.2 endoplasmic reticulum to nucleus signaling 1 protein-coding endoplasmic reticulum to nucleus signaling 1 The proapoptotic genes MOAP1, PHAP, and ERN1 are identified to be the potential targets for the miR-UL70-3p and UL148D, respectively. The ERN1 gene plays a role in the initiation of Endoplasmic reticulum stress-induced apoptosis as well as autophagosome formation. This study shows that HCMV employs its miRNA repertoire for countering the cellular apoptosis and autophagy, particularly the mitochondrial-dependent intrinsic pathway of apoptosis. 2127 miR-UL148D(HCMV) hcmv-miR-UL148D MIMAT0001578 miRNA MOAP1 apoptosis Homo sapiens 24737391 9606 64112 MAP-1|PNMA4 HGNC:16658|MIM:609485|Ensembl:ENSG00000165943|HPRD:17580|Vega:OTTHUMG00000169184 14 14q32 modulator of apoptosis 1 protein-coding modulator of apoptosis 1 The proapoptotic genes MOAP1, PHAP, and ERN1 are identified to be the potential targets for the miR-UL70-3p and UL148D, respectively. The ERN1 gene plays a role in the initiation of Endoplasmic reticulum stress-induced apoptosis as well as autophagosome formation. This study shows that HCMV employs its miRNA repertoire for countering the cellular apoptosis and autophagy, particularly the mitochondrial-dependent intrinsic pathway of apoptosis. 2128 miR-UL70-3p(HCMV) hcmv-miR-UL70-3p MIMAT0003343 miRNA ANP32A apoptosis Homo sapiens 24737391 9606 8125 C15orf1|HPPCn|I1PP2A|LANP|MAPM|PHAP1|PHAPI|PP32 HGNC:13233|MIM:600832|Ensembl:ENSG00000140350|HPRD:09014|Vega:OTTHUMG00000154502 15 15q23 acidic (leucine-rich) nuclear phosphoprotein 32 family, member A protein-coding acidic (leucine-rich) nuclear phosphoprotein 32 family, member A The proapoptotic genes MOAP1, PHAP, and ERN1 are identified to be the potential targets for the miR-UL70-3p and UL148D, respectively. The ERN1 gene plays a role in the initiation of Endoplasmic reticulum stress-induced apoptosis as well as autophagosome formation. This study shows that HCMV employs its miRNA repertoire for countering the cellular apoptosis and autophagy, particularly the mitochondrial-dependent intrinsic pathway of apoptosis. 2129 miR-UL70-3p(HCMV) hcmv-miR-UL70-3p MIMAT0003343 miRNA ERN1 apoptosis Homo sapiens 24737391 9606 2081 IRE1|IRE1P|IRE1a|hIRE1p HGNC:3449|MIM:604033|Ensembl:ENSG00000178607|HPRD:04943|Vega:OTTHUMG00000178879 17 17q24.2 endoplasmic reticulum to nucleus signaling 1 protein-coding endoplasmic reticulum to nucleus signaling 1 The proapoptotic genes MOAP1, PHAP, and ERN1 are identified to be the potential targets for the miR-UL70-3p and UL148D, respectively. The ERN1 gene plays a role in the initiation of Endoplasmic reticulum stress-induced apoptosis as well as autophagosome formation. This study shows that HCMV employs its miRNA repertoire for countering the cellular apoptosis and autophagy, particularly the mitochondrial-dependent intrinsic pathway of apoptosis. 2130 miR-UL70-3p(HCMV) hcmv-miR-UL70-3p MIMAT0003343 miRNA MOAP1 apoptosis Homo sapiens 24737391 9606 64112 MAP-1|PNMA4 HGNC:16658|MIM:609485|Ensembl:ENSG00000165943|HPRD:17580|Vega:OTTHUMG00000169184 14 14q32 modulator of apoptosis 1 protein-coding modulator of apoptosis 1 The proapoptotic genes MOAP1, PHAP, and ERN1 are identified to be the potential targets for the miR-UL70-3p and UL148D, respectively. The ERN1 gene plays a role in the initiation of Endoplasmic reticulum stress-induced apoptosis as well as autophagosome formation. This study shows that HCMV employs its miRNA repertoire for countering the cellular apoptosis and autophagy, particularly the mitochondrial-dependent intrinsic pathway of apoptosis. 2131 let-7 hsa-let-7a-5p,hsa-let-7a-3p,hsa-let-7a-2-3p,hsa-let-7b-5p,hsa-let-7b-3p,hsa-let-7c-5p,hsa-let-7c-3p,hsa-let-7d-5p,hsa-let-7d-3p,hsa-let-7e-5p,hsa-let-7e-3p,hsa-let-7g-5p,hsa-let-7g-3p,hsa-let-7i-5p,hsa-let-7i-3p MIMAT0000062,MIMAT0004481,MIMAT0010195,MIMAT0000063,MIMAT0004482,MIMAT0000064,MIMAT0026472,MIMAT0000065,MIMAT0004484,MIMAT0000066,MIMAT0004485,MIMAT0004486,MIMAT0000414,MIMAT0004584,MIMAT0000415,MIMAT0004585 miRNA apoptosis Homo sapiens 18232304 9606 In this review, we will discuss the function of miRNAs that regulate cell proliferation and apoptosis. Antiapoptotic miRNAs include the miRNAs of the miR-17 cluster, miR-21, bantam and miR-14, Proapoptotic miRNAs include let-7, miR-15a and miR-16. 2132 let-7 hsa-miR-16-5p,hsa-miR-16-1-3p,hsa-miR-16-2-3p MIMAT0000069,MIMAT0004489,MIMAT0004518 miRNA apoptosis Homo sapiens 18232304 9606 In this review, we will discuss the function of miRNAs that regulate cell proliferation and apoptosis. Antiapoptotic miRNAs include the miRNAs of the miR-17 cluster, miR-21, bantam and miR-14, Proapoptotic miRNAs include let-7, miR-15a and miR-16. 2133 let-7a hsa-let-7a-5p,hsa-let-7a-3p,hsa-let-7a-2-3p MIMAT0000062,MIMAT0004481,MIMAT0010195 miRNA HMGA2 apoptosis down Homo sapiens tumor cell 17554199 9606 8091 BABL|HMGI-C|HMGIC|LIPO|STQTL9 HGNC:5009|MIM:600698|Ensembl:ENSG00000149948|HPRD:02827|Vega:OTTHUMG00000168936 12 12q15 high mobility group AT-hook 2 protein-coding high mobility group AT-hook 2 Other p53-induced miRNAs identified here may also have tumor suppressive potential as they are known to suppress the anti-apoptotic factor Bcl2 (miR-15a/16) and the oncogenes RAS and HMGA2 (let-7a). 2134 let-7a hsa-let-7a-5p,hsa-let-7a-3p,hsa-let-7a-2-3p MIMAT0000062,MIMAT0004481,MIMAT0010195 miRNA LIN28A apoptosis down Homo sapiens gastric cancer 25515921 9606 79727 CSDD1|LIN-28|LIN28|ZCCHC1|lin-28A HGNC:15986|MIM:611043|Ensembl:ENSG00000131914|HPRD:17278|Vega:OTTHUMG00000003550 1 1p36.11 lin-28 homolog A (C. elegans) protein-coding lin-28 homolog A (C. elegans) Overexpression of Lin28 was inversely correlated with the downregulated expression of let-7a,and markedly suppressed the proliferation, migration, cell cycle progression and induced apoptosis in the BGC-823 cells. 2135 let-7a hsa-let-7a-5p,hsa-let-7a-3p,hsa-let-7a-2-3p MIMAT0000062,MIMAT0004481,MIMAT0010195 miRNA MIR21 apoptosis down Homo sapiens cholesteatoma keratinocytes 25405753 9606 406991 MIRN21|hsa-mir-21|miR-21|miRNA21 HGNC:31586|MIM:611020|Ensembl:ENSG00000199004|miRBase:MI0000077 17 17q23.1 microRNA 21 ncRNA microRNA 21 Considering the function of miR-21 in the regulation of proliferation and apoptosis, let-7a may control cell proliferation and apoptosis by regulating miR-21, and its targets, in cholesteatoma keratinocytes.In conclusion, the present study showed that let?7a downregulates the expression of miR-21, resulting in the suppression of proliferation and induction of apoptosis. 2136 let-7a hsa-let-7a-5p,hsa-let-7a-3p,hsa-let-7a-2-3p MIMAT0000062,MIMAT0004481,MIMAT0010195 miRNA RASA1 apoptosis down Homo sapiens tumor cell 17554199 9606 5921 CM-AVM|CMAVM|GAP|PKWS|RASA|RASGAP|p120GAP|p120RASGAP HGNC:9871|MIM:139150|Ensembl:ENSG00000145715|HPRD:00745|Vega:OTTHUMG00000162605 5 5q13.3 RAS p21 protein activator (GTPase activating protein) 1 protein-coding RAS p21 protein activator (GTPase activating protein) 1 Other p53-induced miRNAs identified here may also have tumor suppressive potential as they are known to suppress the anti-apoptotic factor Bcl2 (miR-15a/16) and the oncogenes RAS and HMGA2 (let-7a). 2137 let-7e hsa-let-7e-5p,hsa-let-7e-3p MIMAT0000066,MIMAT0004485 miRNA CASP3 apoptosis down Homo sapiens PC12 cells 21827835 9606 836 CPP32|CPP32B|SCA-1 HGNC:1504|MIM:600636|Ensembl:ENSG00000164305|HPRD:02799|Vega:OTTHUMG00000133681 4 4q34 caspase 3, apoptosis-related cysteine peptidase protein-coding caspase 3, apoptosis-related cysteine peptidase These results indicate that let-7e may protect PC12 cells against apoptosis following A/R injury by negatively regulating the expression of Casp3. 2138 miR-1 hsa-miR-1-5p,hsa-miR-1-3p MIMAT0031892,MIMAT0000416 miRNA CASP9 apoptosis down Homo sapiens 21406115 9606 842 APAF-3|APAF3|ICE-LAP6|MCH6|PPP1R56 HGNC:1511|MIM:602234|Ensembl:ENSG00000132906|HPRD:03756|Vega:OTTHUMG00000002256 1 1p36.21 caspase 9, apoptosis-related cysteine peptidase protein-coding caspase 9, apoptosis-related cysteine peptidase Myocardial-specific miR-1 and miR-133a may play an important role in IPost protection by regulating apoptosis-related genes. MiR-133a may attenuate apoptosis of myocardiocytes by targeting CASP9. 2139 miR-1 hsa-miR-1-5p,hsa-miR-1-3p MIMAT0031892,MIMAT0000416 miRNA FOXP1 apoptosis up Homo sapiens hepatocarcinoma cell 18593903 9606 27086 12CC4|QRF1|hFKH1B HGNC:3823|MIM:605515|Ensembl:ENSG00000114861|HPRD:18518|Vega:OTTHUMG00000158803 3 3p14.1 forkhead box P1 protein-coding forkhead box P1 Ectopic expression of miR-1 in HCC cells inhibited cell growth and reduced replication potential and clonogenic survival. The expression of FoxP1 and MET harboring three and two miR-1 cognate sites, respectively, in their respective 3'-untranslated regions, was markedly reduced by ectopic miR-1. Up-regulation of several miR-1 targets including FoxP1, MET, and HDAC4 in primary human HCCs and down-regulation of their expression in 5-AzaC-treated HCC cells suggest their role in hepatocarcinogenesis. The inhibition of cell cycle progression and induction of apoptosis after re-expression of miR-1 are some of the mechanisms by which DNA hypomethylating agents suppress hepatocarcinoma cell growth. 2140 miR-1 hsa-miR-1-5p,hsa-miR-1-3p MIMAT0031892,MIMAT0000416 miRNA HDAC4 apoptosis up Homo sapiens hepatocarcinoma cell 18593903 9606 9759 AHO3|BDMR|HA6116|HD4|HDAC-4|HDAC-A|HDACA HGNC:14063|MIM:605314|Ensembl:ENSG00000068024|HPRD:05610|Vega:OTTHUMG00000133344 2 2q37.3 histone deacetylase 4 protein-coding histone deacetylase 4 Ectopic expression of miR-1 in HCC cells inhibited cell growth and reduced replication potential and clonogenic survival. The expression of FoxP1 and MET harboring three and two miR-1 cognate sites, respectively, in their respective 3'-untranslated regions, was markedly reduced by ectopic miR-1. Up-regulation of several miR-1 targets including FoxP1, MET, and HDAC4 in primary human HCCs and down-regulation of their expression in 5-AzaC-treated HCC cells suggest their role in hepatocarcinogenesis. The inhibition of cell cycle progression and induction of apoptosis after re-expression of miR-1 are some of the mechanisms by which DNA hypomethylating agents suppress hepatocarcinoma cell growth. 2141 miR-1 hsa-miR-1-5p,hsa-miR-1-3p MIMAT0031892,MIMAT0000416 miRNA MET apoptosis up Homo sapiens hepatocarcinoma cell 18593903 9606 4233 AUTS9|HGFR|RCCP2|c-Met HGNC:7029|MIM:164860|Ensembl:ENSG00000105976|HPRD:01280|Vega:OTTHUMG00000023299 7 7q31 MET proto-oncogene, receptor tyrosine kinase protein-coding MET proto-oncogene, receptor tyrosine kinase Ectopic expression of miR-1 in HCC cells inhibited cell growth and reduced replication potential and clonogenic survival. The expression of FoxP1 and MET harboring three and two miR-1 cognate sites, respectively, in their respective 3'-untranslated regions, was markedly reduced by ectopic miR-1. Up-regulation of several miR-1 targets including FoxP1, MET, and HDAC4 in primary human HCCs and down-regulation of their expression in 5-AzaC-treated HCC cells suggest their role in hepatocarcinogenesis. The inhibition of cell cycle progression and induction of apoptosis after re-expression of miR-1 are some of the mechanisms by which DNA hypomethylating agents suppress hepatocarcinoma cell growth. 2142 miR-1 hsa-miR-1-5p,hsa-miR-1-3p MIMAT0031892,MIMAT0000416 miRNA PNP apoptosis down Homo sapiens maxillary sinus squamous cell carcinoma 21701775 9606 4860 NP|PRO1837|PUNP HGNC:7892|MIM:164050|HPRD:01247 14 14q13.1 purine nucleoside phosphorylase protein-coding purine nucleoside phosphorylase Restoration of downregulated miRNAs (miR-1 or miR-133a) in cancer cells revealed that both miRNAs significantly inhibited cancer cell proliferation and induced cell apoptosis. Molecular target identification of these miRNAs showed that transgelin 2 (TAGLN2) and purine nucleoside phosphorylase (PNP) were regulated by miR-1 and miR-133a. 2143 miR-1 hsa-miR-1-5p,hsa-miR-1-3p MIMAT0031892,MIMAT0000416 miRNA TAGLN2 apoptosis down Homo sapiens head and neck squamous cell carcinoma 21378409 9606 8407 HA1756 HGNC:11554|MIM:604634|Ensembl:ENSG00000158710|HPRD:06864|Vega:OTTHUMG00000022793 1 1q21-q25 transgelin 2 protein-coding transgelin 2 In addition, the promotion of cell apoptosis and cell cycle arrest was demonstrated following miR-1e transfection of cancer cells. A search for the targets of miR-1 revealed that transgelin 2 (TAGLN2) was directly regulated by miR-1. 2144 miR-1 hsa-miR-1-5p,hsa-miR-1-3p MIMAT0031892,MIMAT0000416 miRNA TAGLN2 apoptosis down Homo sapiens maxillary sinus squamous cell carcinoma 21701775 9606 8407 HA1756 HGNC:11554|MIM:604634|Ensembl:ENSG00000158710|HPRD:06864|Vega:OTTHUMG00000022793 1 1q21-q25 transgelin 2 protein-coding transgelin 2 Restoration of downregulated miRNAs (miR-1 or miR-133a) in cancer cells revealed that both miRNAs significantly inhibited cancer cell proliferation and induced cell apoptosis. Molecular target identification of these miRNAs showed that transgelin 2 (TAGLN2) and purine nucleoside phosphorylase (PNP) were regulated by miR-1 and miR-133a. 2145 miR-1 hsa-miR-1-5p,hsa-miR-1-3p MIMAT0031892,MIMAT0000416 miRNA apoptosis Homo sapiens dilated cardiomyopathy 25361207 9606 We showed that individual silencing of 7 out of 8 significantly down-regulated miRNAs (mir-1, -29c, -30c, -30d, -149, -486, -499) led to a strong apoptotic phenotype in cell culture, suggesting they repress pro-apoptotic factors. 2146 miR-100 hsa-miR-100-5p,hsa-miR-100-3p MIMAT0000098,MIMAT0004512 miRNA BAZ2A apoptosis down Homo sapiens bladder cancer cell 25493074 9606 11176 TIP5|WALp3 HGNC:962|MIM:605682|Ensembl:ENSG00000076108|HPRD:10417|Vega:OTTHUMG00000170332 12 12q13.3 bromodomain adjacent to zinc finger domain, 2A protein-coding bromodomain adjacent to zinc finger domain, 2A miR-100 transfection reduces expression of BAZ2A, mTOR and SMARCA5 mRNA and protein in BC cell lines. miR-100 would be classified as an oncomiR in T24 cells representative of high grade urothelial carcinoma promoting increase in cell proliferation and reduction in apoptosis. 2147 miR-100 hsa-miR-100-5p,hsa-miR-100-3p MIMAT0000098,MIMAT0004512 miRNA MTOR apoptosis down Homo sapiens bladder cancer cell 25493074 9606 2475 FRAP|FRAP1|FRAP2|RAFT1|RAPT1 HGNC:3942|MIM:601231|Ensembl:ENSG00000198793|HPRD:03134|Vega:OTTHUMG00000002001 1 1p36.2 mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) miR-100 transfection reduces expression of BAZ2A, mTOR and SMARCA5 mRNA and protein in BC cell lines. miR-100 would be classified as an oncomiR in T24 cells representative of high grade urothelial carcinoma promoting increase in cell proliferation and reduction in apoptosis. 2148 miR-100 hsa-miR-100-5p,hsa-miR-100-3p MIMAT0000098,MIMAT0004512 miRNA SMARCA5 apoptosis down Homo sapiens bladder cancer cell 25493074 9606 8467 ISWI|SNF2H|WCRF135|hISWI|hSNF2H HGNC:11101|MIM:603375|Ensembl:ENSG00000153147|HPRD:04538|Vega:OTTHUMG00000161474 4 4q31.1-q31.2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 protein-coding SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 miR-100 transfection reduces expression of BAZ2A, mTOR and SMARCA5 mRNA and protein in BC cell lines. miR-100 would be classified as an oncomiR in T24 cells representative of high grade urothelial carcinoma promoting increase in cell proliferation and reduction in apoptosis. 2149 miR-101 hsa-miR-101-5p,hsa-miR-101-3p MIMAT0004513,MIMAT0000099 miRNA COX2 apoptosis down Homo sapiens bladder cancer 25109742 9606 4513 COII|MTCO2 HGNC:7421|MIM:516040 MT - cytochrome c oxidase subunit II protein-coding mitochondrially encoded cytochrome c oxidase II Furthermore,overexpression of miR-101 significantly increased the anti?proliferative effects and apoptosis induced by cisplatin, whereas knockdown of miR-101 significantly decreased the anti?proliferative effects and apoptosis induced by cisplatin. In addition, downregulation of miR-101 induced cell survival and cisplatin resistance through the upregulation of COX?2 expression. Luciferase gene reporter assays confirmed that COX?2 was a direct target gene of miR-101. 2150 miR-101 hsa-miR-101-5p,hsa-miR-101-3p MIMAT0004513,MIMAT0000099 miRNA EZH2 apoptosis down Homo sapiens HCC tissues 24211739 9606 2146 ENX-1|ENX1|EZH1|EZH2b|KMT6|KMT6A|WVS|WVS2 HGNC:3527|MIM:601573|Ensembl:ENSG00000106462|HPRD:03342|Vega:OTTHUMG00000158973 7 7q35-q36 enhancer of zeste 2 polycomb repressive complex 2 subunit protein-coding enhancer of zeste 2 polycomb repressive complex 2 subunit There was a negative correlation betweenexpression levels of miR-101 and EZH2. Luciferase assay results confirmed EZH2 asa direct target gene of miR-101, which negatively regulates EZH2 expression inHCC. Ectopic overexpression of miR-101 dramatically repressed proliferation,invasion, colony formation as well as cell cycle progression in vitro andsuppressed tumorigenicity in vivo. Furthermore, miR-101 inhibited autophagy andsynergized with either doxorubicin or fluorouracil to induce apoptosis in tumorcells. 2151 miR-101 hsa-miR-101-5p,hsa-miR-101-3p MIMAT0004513,MIMAT0000099 miRNA EZH2 apoptosis down Homo sapiens endometrial 25153722 9606 2146 ENX-1|ENX1|EZH1|EZH2b|KMT6|KMT6A|WVS|WVS2 HGNC:3527|MIM:601573|Ensembl:ENSG00000106462|HPRD:03342|Vega:OTTHUMG00000158973 7 7q35-q36 enhancer of zeste 2 polycomb repressive complex 2 subunit protein-coding enhancer of zeste 2 polycomb repressive complex 2 subunit Here, we report that in aggressive endometrial cancer cells, re-expression of microRNA-101 leads to inhibition of cell proliferation and induction of apoptosis and senescence.we validated EZH2, MCL-1 and FOS as direct targets of miR-101 and silencing of these genes mimics the tumor suppressive effects observed on promoting microRNA-101 function. 2152 miR-101 hsa-miR-101-5p,hsa-miR-101-3p MIMAT0004513,MIMAT0000099 miRNA FOS apoptosis down Homo sapiens endometrial 25153722 9606 2353 AP-1|C-FOS|p55 HGNC:3796|MIM:164810|Ensembl:ENSG00000170345|HPRD:01275|Vega:OTTHUMG00000171774 14 14q24.3 FBJ murine osteosarcoma viral oncogene homolog protein-coding FBJ murine osteosarcoma viral oncogene homolog Here, we report that in aggressive endometrial cancer cells, re-expression of microRNA-101 leads to inhibition of cell proliferation and induction of apoptosis and senescence.we validated EZH2, MCL-1 and FOS as direct targets of miR-101 and silencing of these genes mimics the tumor suppressive effects observed on promoting microRNA-101 function. 2153 miR-101 hsa-miR-101-5p,hsa-miR-101-3p MIMAT0004513,MIMAT0000099 miRNA MCL1 apoptosis down Homo sapiens endometrial 25153722 9606 4170 BCL2L3|EAT|MCL1-ES|MCL1L|MCL1S|Mcl-1|TM|bcl2-L-3|mcl1/EAT HGNC:6943|MIM:159552|Ensembl:ENSG00000143384|HPRD:08870|Vega:OTTHUMG00000034867 1 1q21 myeloid cell leukemia 1 protein-coding myeloid cell leukemia 1 Here, we report that in aggressive endometrial cancer cells, re-expression of microRNA-101 leads to inhibition of cell proliferation and induction of apoptosis and senescence.we validated EZH2, MCL-1 and FOS as direct targets of miR-101 and silencing of these genes mimics the tumor suppressive effects observed on promoting microRNA-101 function. 2154 miR-103 hsa-miR-103a-3p,hsa-miR-103b,hsa-miR-103a-2-5p MIMAT0000101,MIMAT0007402,MIMAT0009196 miRNA PRKCE apoptosis down Homo sapiens non-small cell lung cancers 22157681 9606 5581 PKCE|nPKC-epsilon HGNC:9401|MIM:176975|Ensembl:ENSG00000171132|HPRD:01500|Vega:OTTHUMG00000128817 2 2p21 protein kinase C, epsilon protein-coding protein kinase C, epsilon Here we report that miR-30b/c and miR-221/222, modulated by both EGF and MET receptors, and miR-103, -203, controlled only by MET, play important roles in gefitinib-induced apoptosis and epithelial-mesenchymal transition (EMT) of NSCLC cells, in vitro and in vivo, by inhibiting the expression of Bim, APAF-1, PKC-¦Å and SRC genes. 2155 miR-103 hsa-miR-103a-3p,hsa-miR-103b,hsa-miR-103a-2-5p MIMAT0000101,MIMAT0007402,MIMAT0009196 miRNA apoptosis down Homo sapiens non-small cell lung cancers 22157681 9606 Here we report that miR-30b/c and miR-221/222, modulated by both EGF and MET receptors, and miR-103, -203, controlled only by MET, play important roles in gefitinib-induced apoptosis and epithelial-mesenchymal transition (EMT) of NSCLC cells, in vitro and in vivo, by inhibiting the expression of Bim, APAF-1, PKC-¦Å and SRC genes. 2156 miR-106a hsa-miR-106a-5p,hsa-miR-106a-3p MIMAT0000103,MIMAT0004517 miRNA CDKN1A apoptosis down Homo sapiens hepatocellular carcinoma 25510666 9606 1026 CAP20|CDKN1|CIP1|MDA-6|P21|SDI1|WAF1|p21CIP1 HGNC:1784|MIM:116899|Ensembl:ENSG00000124762|HPRD:00298|Vega:OTTHUMG00000014603 6 6p21.2 cyclin-dependent kinase inhibitor 1A (p21, Cip1) protein-coding cyclin-dependent kinase inhibitor 1A (p21, Cip1) We further used dual-luciferase reporter gene assay to ensure that TP53INP1 and CDKN1A might be the direct targets of miR-106a. At last, we explored the functions of miR-106a in HCC cells in vitro. Our results manifested that high-miR-106a cell line had stronger invasiveness, faster cell cycle progression, and more resistance to apoptosis compared with the low-miR-106a cell line. 2157 miR-106a hsa-miR-106a-5p,hsa-miR-106a-3p MIMAT0000103,MIMAT0004517 miRNA TP53INP1 apoptosis down Homo sapiens hepatocellular carcinoma 25510666 9606 94241 SIP|TP53DINP1|TP53INP1A|TP53INP1B|Teap|p53DINP1 HGNC:18022|MIM:606185|Ensembl:ENSG00000164938|HPRD:09367|Vega:OTTHUMG00000164697 8 8q22 tumor protein p53 inducible nuclear protein 1 protein-coding tumor protein p53 inducible nuclear protein 1 we further used dual-luciferase reporter gene assay to ensure that TP53INP1 and CDKN1A might be the direct targets of miR-106a. At last, we explored the functions of miR-106a in HCC cells in vitro. Our results manifested that high-miR-106a cell line had stronger invasiveness, faster cell cycle progression, and more resistance to apoptosis compared with the low-miR-106a cell line. 2158 miR-106b hsa-miR-106b-5p,hsa-miR-106b-3p MIMAT0000680,MIMAT0004672 miRNA BCL2L11 apoptosis down Homo sapiens kidney 21546576 9606 10018 BAM|BIM|BOD HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 2 2q13 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) Here, we found that the loss of miRNAs in nephron progenitors results in a premature depletion of this population during kidney development. Increased apoptosis and expression of the pro-apoptotic protein Bim accompanied this depletion. Profiling of miRNA expression during nephrogenesis identified several highly expressed miRNAs (miR-10a, miR-106b, miR-17-5p) in nephron progenitors that are either known or predicted to target Bim. 2159 miR-106b hsa-miR-106b-5p,hsa-miR-106b-3p MIMAT0000680,MIMAT0004672 miRNA CDKN1A apoptosis down Homo sapiens lymphoma 21953646 9606 1026 CAP20|CDKN1|CIP1|MDA-6|P21|SDI1|WAF1|p21CIP1 HGNC:1784|MIM:116899|Ensembl:ENSG00000124762|HPRD:00298|Vega:OTTHUMG00000014603 6 6p21.2 cyclin-dependent kinase inhibitor 1A (p21, Cip1) protein-coding cyclin-dependent kinase inhibitor 1A (p21, Cip1) Alterations in the cell cycle and apoptosis pathways might contribute to their resistance to apoptosis and sustained cell cycle progression. A key player in both cell cycle arrest and apoptosis is CDKN1A, encoding p21. We showed effective targeting of the CDKN1A 3' UTR by miR-17/106b in HL cell lines in a luciferase reporter assay and up-regulation of p21 protein levels upon anti-miR-17 treatment of KM-H2 cells. 2160 miR-106b hsa-miR-106b-5p,hsa-miR-106b-3p MIMAT0000680,MIMAT0004672 miRNA CDKN1A apoptosis down Homo sapiens cardiovascular 22613985 9606 1026 CAP20|CDKN1|CIP1|MDA-6|P21|SDI1|WAF1|p21CIP1 HGNC:1784|MIM:116899|Ensembl:ENSG00000124762|HPRD:00298|Vega:OTTHUMG00000014603 6 6p21.2 cyclin-dependent kinase inhibitor 1A (p21, Cip1) protein-coding cyclin-dependent kinase inhibitor 1A (p21, Cip1) Moreover, experimental data supported bioinformatic predictions that miR-106b served as an anti-apoptotic modulator through inhibition of p21 expression and miR-15b displayed anti-angiogenesis activity. 2161 miR-106b hsa-miR-106b-5p,hsa-miR-106b-3p MIMAT0000680,MIMAT0004672 miRNA apoptosis Homo sapiens gastrointestinal and other tumors 18922889 9606 The miR-106b-25 and miR-17-92 clusters are emerging as key modulators of TGFbeta signaling in gastrointestinal and other tumors, interfering with cell cycle arrest and apoptosis when overexpressed in cancer cells. 2162 miR-106b-5p hsa-miR-106a-5p MIMAT0000103 miRNA SETD2 apoptosis down Homo sapiens clear cell renal cell carcinoma 25714014 9606 29072 HBP231|HIF-1|HIP-1|HYPB|KMT3A|SET2|p231HBP HGNC:18420|MIM:612778|Ensembl:ENSG00000181555|HPRD:11043|Vega:OTTHUMG00000133514 3 3p21.31 SET domain containing 2 protein-coding SET domain containing 2 Over-expression of miR-106b-5p resulted in the decreased mRNA and protein levels of SETD2 in ccRCC cells. In an SETD2 3'-UTR luciferase reporter system, miR-106b-5p downregulated the luciferase activity,and the effects were abolished by mutating the predicted miR-106b-5p binding site. Moreover, attenuation of miR-106b-5p induced cell cycle arrest at G0/G1 phase, suppressed cell proliferation, enhanced processing of caspase-3, and promoted cell apoptosis in ccRCC cells, whereas these effects were reversed upon knockdown of SETD2. 2163 miR-10a hsa-miR-10a-5p,hsa-miR-10a-3p MIMAT0000253,MIMAT0004555 miRNA BCL2L11 apoptosis down Homo sapiens kidney 21546576 9606 10018 BAM|BIM|BOD HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 2 2q13 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) Here, we found that the loss of miRNAs in nephron progenitors results in a premature depletion of this population during kidney development. Increased apoptosis and expression of the pro-apoptotic protein Bim accompanied this depletion. Profiling of miRNA expression during nephrogenesis identified several highly expressed miRNAs (miR-10a, miR-106b, miR-17-5p) in nephron progenitors that are either known or predicted to target Bim. 2164 miR-10b hsa-miR-10b-5p,hsa-miR-10b-3p MIMAT0000254,MIMAT0004556 miRNA BCL2L11 apoptosis Homo sapiens renal glomerular endothelial cells 25659925 9606 10018 BAM|BIM|BOD HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 2 2q13 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) Downregulation ofmiR-10b directly derepressed the expression of BCL2L11 (an apoptosis inducer) as revealed by luciferase reporter assay. 2165 miR-10b-5p hsa-miR-10b-5p MIMAT0000254 miRNA BTRC apoptosis down Homo sapiens myeloma 25330074 9606 8945 BETA-TRCP|FBW1A|FBXW1|FBXW1A|FWD1|bTrCP|bTrCP1|betaTrCP HGNC:1144|MIM:603482|Ensembl:ENSG00000166167|HPRD:04596|Vega:OTTHUMG00000018932 10 10q24.32 beta-transducin repeat containing E3 ubiquitin protein ligase protein-coding beta-transducin repeat containing E3 ubiquitin protein ligase The effects of these miRNAs in modulating MM cell apoptosis was also investigated; re-expression of miR-152, -10b-5p and miR-34c-3p mimics induced cleavage of PARP- and caspase-9 and -3, compared to normal control-transfected cells.beta-transducin repeat containing E3 ubiquitin protein ligase (BTRC) and Myc binding protein (MYCBP), predicted targets of miR-10b-5p.In addition, E2F3, BTRC and MYCBP were significantly increased after miR-10b-5p mimic transfection 2166 miR-10b-5p hsa-miR-10b-5p MIMAT0000254 miRNA E2F3 apoptosis down Homo sapiens myeloma 25330074 9606 1871 E2F-3 HGNC:3115|MIM:600427|Ensembl:ENSG00000112242|HPRD:02693|Vega:OTTHUMG00000016389 6 6p22 E2F transcription factor 3 protein-coding E2F transcription factor 3 The effects of these miRNAs in modulating MM cell apoptosis was also investigated; re-expression of miR-152, -10b-5p and miR-34c-3p mimics induced cleavage of PARP- and caspase-9 and -3, compared to normal control-transfected cells.E2F transcription factor 3 (E2F3), predicted target of both miR-152 and miR-10b-5p were examined in MM cells,In addition, E2F3 were significantly increased after miR-10b-5p mimic transfection 2167 miR-10b-5p hsa-miR-10b-5p MIMAT0000254 miRNA MYCBP apoptosis down Homo sapiens myeloma 25330074 9606 26292 AMY-1 HGNC:7554|MIM:606535|HPRD:08406|Vega:OTTHUMG00000000484 1 1p33-p32.2 MYC binding protein protein-coding MYC binding protein The effects of these miRNAs in modulating MM cell apoptosis was also investigated; re-expression of miR-152, -10b-5p and miR-34c-3p mimics induced cleavage of PARP- and caspase-9 and -3, compared to normal control-transfected cells.beta-transducin repeat containing E3 ubiquitin protein ligase (BTRC) and Myc binding protein (MYCBP), predicted targets of miR-10b-5p.In addition, E2F3, BTRC and MYCBP were significantly increased after miR-10b-5p mimic transfection 2168 miR-122 hsa-miR-122-5p,hsa-miR-122-3p MIMAT0000421,MIMAT0004590 miRNA AKT1 apoptosis up Homo sapiens cutaneous T-cell lymphoma 22235305 9606 207 AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA HGNC:391|MIM:164730|Ensembl:ENSG00000142208|HPRD:01261|Vega:OTTHUMG00000170795 14 14q32.32 v-akt murine thymoma viral oncogene homolog 1 protein-coding v-akt murine thymoma viral oncogene homolog 1 Using a recently established model in which apoptosis of CTCL cell lines is induced by Notch-1 inhibition by ¦Ã-secretase inhibitors (GSIs), we found that miR-122 was significantly increased in the apoptotic cells. miR-122 up-regulation was not specific for GSI-1 but was also seen during apoptosis induced by chemotherapies including doxorubicin and proteasome blockers (bortezomib, MG132). Surprisingly, miR-122 overexpression decreased the sensitivity to the chemotherapy-induced apoptosis via a signaling circuit involving the activation of Akt and inhibition of p53. 2169 miR-122 hsa-miR-122-5p,hsa-miR-122-3p MIMAT0000421,MIMAT0004590 miRNA GALNT10 apoptosis down Homo sapiens hepatoma 25422324 9606 55568 GALNACT10|PPGALNACT10|PPGANTASE10 HGNC:19873|MIM:608043|Ensembl:ENSG00000164574|HPRD:12157|Vega:OTTHUMG00000130145 5 5q33.2 polypeptide N-acetylgalactosaminyltransferase 10 protein-coding polypeptide N-acetylgalactosaminyltransferase 10 Furthermore, UDP-N-acetyl-¦Á-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-10 (GALNT10) was identified as a bona fide target of miR-122 in hepatoma cells. Ectopic expression and knockdown studies showed that GALNT10 indeed promotes proliferation and apoptosis resistance of hepatoma cells in a glycosyl transferase-dependent manner. 2170 miR-122 hsa-miR-122-5p,hsa-miR-122-3p MIMAT0000421,MIMAT0004590 miRNA TP53 apoptosis down Homo sapiens cutaneous T-cell lymphoma 22235305 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 Using a recently established model in which apoptosis of CTCL cell lines is induced by Notch-1 inhibition by ¦Ã-secretase inhibitors (GSIs), we found that miR-122 was significantly increased in the apoptotic cells. miR-122 up-regulation was not specific for GSI-1 but was also seen during apoptosis induced by chemotherapies including doxorubicin and proteasome blockers (bortezomib, MG132). Surprisingly,miR-122 overexpression decreased the sensitivity to the chemotherapy-induced apoptosis via a signaling circuit involving the activation of Akt and inhibition of p53. 2171 miR-124 hsa-miR-124-3p,hsa-miR-124-5p MIMAT0000422,MIMAT0004591 miRNA AHR apoptosis down Homo sapiens neuroblastoma 22024478 9606 196 bHLHe76 HGNC:348|MIM:600253|Ensembl:ENSG00000106546|HPRD:02596|Vega:OTTHUMG00000149967 7 7p15 aryl hydrocarbon receptor protein-coding aryl hydrocarbon receptor Knockdown of miR-124 promotes neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis. Further miR-124 is predicted to target aryl hydrocarbon receptor (AHR) which may promote neuroblastoma cell differentiation. We validate that miR-124 may suppress the expression of AHR by targeting its 3'-UTR. 2172 miR-124 hsa-miR-124-3p,hsa-miR-124-5p MIMAT0000422,MIMAT0004591 miRNA PDE4B apoptosis down Homo sapiens DLBCL cell lines 25576220 9606 5142 DPDE4|PDEIVB HGNC:8781|MIM:600127|Ensembl:ENSG00000184588|HPRD:02528|Vega:OTTHUMG00000009088 1 1p31 phosphodiesterase 4B, cAMP-specific protein-coding phosphodiesterase 4B, cAMP-specific Here, we show that miR-124 influences GC-induced apoptosis bydirectly targeting PDE4B. Stable expression of miR-124 in diffuse large B celllymphoma (DLBCL) cell lines diminished PDE4B expression. 2173 miR-124 hsa-miR-124-3p,hsa-miR-124-5p MIMAT0000422,MIMAT0004591 miRNA PTBP1 apoptosis Homo sapiens colon cancer cell 25818238 9606 5725 HNRNP-I|HNRNPI|HNRPI|PTB|PTB-1|PTB-T|PTB2|PTB3|PTB4|pPTB HGNC:9583|MIM:600693|Ensembl:ENSG00000011304|HPRD:02823|Vega:OTTHUMG00000181789 19 19p13.3 polypyrimidine tract binding protein 1 protein-coding polypyrimidine tract binding protein 1 Also, miR-124 targeted polypyrimidine tract-binding protein 1 (PTB1), which is a splicer of pyruvate kinase muscle 1 and 2 (PKM1 and PKM2) and induced the switching of PKM isoforms expression from PKM2 to PKM1. Also, siR-PTB1 induced drastic apoptosis in colon cancer cells. 2174 miR-125a hsa-miR-125a-5p,hsa-miR-125a-3p MIMAT0000443,MIMAT0004602 miRNA NTRK3 apoptosis Homo sapiens medulloblastoma 18973228 9606 4916 TRKC|gp145(trkC) HGNC:8033|MIM:191316|Ensembl:ENSG00000140538|HPRD:01870|Vega:OTTHUMG00000148677 15 15q25 neurotrophic tyrosine kinase, receptor, type 3 protein-coding neurotrophic tyrosine kinase, receptor, type 3 This property has been addressed for miR-9 and miR-125a, whose rescued expression promoted medulloblastoma cell growth arrest and apoptosis while targeting the proproliferative truncated TrkC isoform. 2175 miR-125a-3p hsa-miR-125a-3p MIMAT0004602 miRNA EGR1 apoptosis down Homo sapiens 25725290 9606 1958 AT225|G0S30|KROX-24|NGFI-A|TIS8|ZIF-268|ZNF225 HGNC:3238|MIM:128990|Ensembl:ENSG00000120738|HPRD:00549|Vega:OTTHUMG00000129197 5 5q31.1 early growth response 1 protein-coding early growth response 1 Early growth response gene 1 (Egr1) has long been considered as tumor suppressor and transcriptional factor involved in cell proliferation and regulation of apoptosis.Further, we found that Egr1 modulates the silencing activity of miR-125a-3p in vivo. 2176 miR-125b miRNA BAK1 apoptosis Homo sapiens 21935352 9606 578 BAK|BAK-LIKE|BCL2L7|CDN1 HGNC:949|MIM:600516|Ensembl:ENSG00000030110|HPRD:02744|Vega:OTTHUMG00000014530 6 6p21.3 BCL2-antagonist/killer 1 protein-coding BCL2-antagonist/killer 1 By using a gain- and loss-of-function screen for miR-125b targets in humans, mice, and zebrafish and by validating these targets with the luciferase assay and a novel miRNA pull-down assay, we demonstrate that miR-125b directly represses 20 novel targets in the p53 network. These targets include both apoptosis regulators like Bak1, Igfbp3, Itch, Puma, Prkra, Tp53inp1, Tp53, Zac1 2177 miR-125b hsa-miR-125b-5p,hsa-miR-125b-1-3p,hsa-miR-125b-2-3p MIMAT0000423,MIMAT0004592,MIMAT0004603 miRNA BAK1 apoptosis down Homo sapiens 22252650 9606 578 BAK|BAK-LIKE|BCL2L7|CDN1 HGNC:949|MIM:600516|Ensembl:ENSG00000030110|HPRD:02744|Vega:OTTHUMG00000014530 6 6p21.3 BCL2-antagonist/killer 1 protein-coding BCL2-antagonist/killer 1 In addition, we demonstrated that CPT induced apoptosis in cancer cells by miR-125b-mediated mitochondrial pathways via targeting to the 3'-untranslated (UTR) regions of Bak1, Mcl1, and p53. 2178 miR-125b miRNA BBC3 apoptosis Homo sapiens 21935352 9606 27113 JFY-1|JFY1|PUMA HGNC:17868|MIM:605854|Ensembl:ENSG00000105327|HPRD:16165|Vega:OTTHUMG00000183489 19 19q13.3-q13.4 BCL2 binding component 3 protein-coding BCL2 binding component 3 By using a gain- and loss-of-function screen for miR-125b targets in humans, mice, and zebrafish and by validating these targets with the luciferase assay and a novel miRNA pull-down assay, we demonstrate that miR-125b directly represses 20 novel targets in the p53 network.These targets include both apoptosis regulators like Bak1, Igfbp3, Itch, Puma, Prkra, Tp53inp1, Tp53, Zac1 2179 miR-125b hsa-miR-125b-5p,hsa-miR-125b-1-3p,hsa-miR-125b-2-3p MIMAT0000423,MIMAT0004592,MIMAT0004603 miRNA BCL2 apoptosis down Homo sapiens 22139839 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 We suggest that miR-155 and miR-125b, which are induced by CD154 and stromal cell signals, contribute to regulating proliferation and that BCL2 is one of their target mRNAs. 2180 miR-125b miRNA IGFBP3 apoptosis Homo sapiens 21935352 9606 3486 BP-53|IBP3 HGNC:5472|MIM:146732|Ensembl:ENSG00000146674|HPRD:00899|Vega:OTTHUMG00000023769 7 7p13-p12 insulin-like growth factor binding protein 3 protein-coding insulin-like growth factor binding protein 3 By using a gain- and loss-of-function screen for miR-125b targets in humans, mice, and zebrafish and by validating these targets with the luciferase assay and a novel miRNA pull-down assay, we demonstrate that miR-125b directly represses 20 novel targets in the p53 network.These targets include both apoptosis regulators like Bak1, Igfbp3, Itch, Puma, Prkra, Tp53inp1, Tp53, Zac1 2181 miR-125b hsa-miR-125b-5p,hsa-miR-125b-1-3p,hsa-miR-125b-2-3p MIMAT0000423,MIMAT0004592,MIMAT0004603 miRNA MCL1 apoptosis down Homo sapiens 22252650 9606 4170 BCL2L3|EAT|MCL1-ES|MCL1L|MCL1S|Mcl-1|TM|bcl2-L-3|mcl1/EAT HGNC:6943|MIM:159552|Ensembl:ENSG00000143384|HPRD:08870|Vega:OTTHUMG00000034867 1 1q21 myeloid cell leukemia 1 protein-coding myeloid cell leukemia 1 In addition, we demonstrated that CPT induced apoptosis in cancer cells by miR-125b-mediated mitochondrial pathways via targeting to the 3'-untranslated (UTR) regions of Bak1, Mcl1, and p53. 2182 miR-125b miRNA PLAGL1 apoptosis Homo sapiens 21935352 9606 5325 LOT1|ZAC|ZAC1 HGNC:9046|MIM:603044|Ensembl:ENSG00000118495|HPRD:16010|Vega:OTTHUMG00000015738 6 6q24-q25 pleiomorphic adenoma gene-like 1 protein-coding pleiomorphic adenoma gene-like 1 By using a gain- and loss-of-function screen for miR-125b targets in humans, mice, and zebrafish and by validating these targets with the luciferase assay and a novel miRNA pull-down assay, we demonstrate that miR-125b directly represses 20 novel targets in the p53 network.These targets include both apoptosis regulators like Bak1, Igfbp3, Itch, Puma, Prkra, Tp53inp1, Tp53, Zac1 2183 miR-125b miRNA PRKRA apoptosis Homo sapiens 21935352 9606 8575 DYT16|PACT|RAX HGNC:9438|MIM:603424|Ensembl:ENSG00000180228|HPRD:04573|Vega:OTTHUMG00000132576 2 2q31.2 protein kinase, interferon-inducible double stranded RNA dependent activator protein-coding protein kinase, interferon-inducible double stranded RNA dependent activator By using a gain- and loss-of-function screen for miR-125b targets in humans, mice, and zebrafish and by validating these targets with the luciferase assay and a novel miRNA pull-down assay, we demonstrate that miR-125b directly represses 20 novel targets in the p53 network.These targets include both apoptosis regulators like Bak1, Igfbp3, Itch, Puma, Prkra, Tp53inp1, Tp53, Zac1 2184 miR-125b miRNA TP53 apoptosis Homo sapiens 21935352 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 By using a gain- and loss-of-function screen for miR-125b targets in humans, mice, and zebrafish and by validating these targets with the luciferase assay and a novel miRNA pull-down assay, we demonstrate that miR-125b directly represses 20 novel targets in the p53 network.These targets include both apoptosis regulators like Bak1, Igfbp3, Itch, Puma, Prkra, Tp53inp1, Tp53, Zac1 2185 miR-125b hsa-miR-125b-5p,hsa-miR-125b-1-3p,hsa-miR-125b-2-3p MIMAT0000423,MIMAT0004592,MIMAT0004603 miRNA TP53 apoptosis down Homo sapiens 22252650 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 In addition, we demonstrated that CPT induced apoptosis in cancer cells by miR-125b-mediated mitochondrial pathways via targeting to the 3'-untranslated (UTR) regions of Bak1, Mcl1, and p53. 2186 miR-125b hsa-miR-125b-5p,hsa-miR-125b-1-3p,hsa-miR-125b-2-3p MIMAT0000423,MIMAT0004592,MIMAT0004603 miRNA apoptosis Homo sapiens cutaneous malignant melanoma 21460750 9606 In contrast, inhibition of miR-125b resulted in 30-35% decreased levels of spontaneous apoptosis. 2187 miR-128 hsa-miR-128-3p,hsa-miR-1285-5p MIMAT0000424,MIMAT0005876 miRNA BAG2 apoptosis down Homo sapiens head and neck squamous cell carcinoma 25764126 9606 9532 BAG-2|dJ417I1.2 HGNC:938|MIM:603882|HPRD:04859 6 6p12.1-p11.2 BCL2-associated athanogene 2 protein-coding BCL2-associated athanogene 2 Functions of MiRNA-128 on the Regulation of Head and Neck Squamous Cell Carcinoma Growth and Apoptosis. miRNA-128 was able to bind with the 3'-untranslated regions of BMI-1, BAG-2, BAX, H3f3b, and Paip2 mRNAs, resulting in significant reduction of the targeted protein levels. 2188 miR-128 hsa-miR-128-3p,hsa-miR-1285-5p MIMAT0000424,MIMAT0005876 miRNA BAX apoptosis down Homo sapiens head and neck squamous cell carcinoma 25764126 9606 581 BCL2L4 HGNC:959|MIM:600040|Ensembl:ENSG00000087088|HPRD:02498|Vega:OTTHUMG00000160476 19 19q13.3-q13.4 BCL2-associated X protein protein-coding BCL2-associated X protein Functions of MiRNA-128 on the Regulation of Head and Neck Squamous Cell Carcinoma Growth and Apoptosis. miRNA-128 was able to bind with the 3'-untranslated regions of BMI-1, BAG-2, BAX, H3f3b, and Paip2 mRNAs, resulting in significant reduction of the targeted protein levels. 2189 miR-128 hsa-miR-128-3p,hsa-miR-1285-5p MIMAT0000424,MIMAT0005876 miRNA BMI1 apoptosis down Homo sapiens head and neck squamous cell carcinoma 25764126 9606 648 FLVI2/BMI1|PCGF4|RNF51 HGNC:1066|MIM:164831|Ensembl:ENSG00000168283|HPRD:01277|Vega:OTTHUMG00000017807 10 10p11.23 BMI1 proto-oncogene, polycomb ring finger protein-coding BMI1 proto-oncogene, polycomb ring finger Functions of MiRNA-128 on the Regulation of Head and Neck Squamous Cell Carcinoma Growth and Apoptosis. miRNA-128 was able to bind with the 3'-untranslated regions of BMI-1, BAG-2, BAX, H3f3b, and Paip2 mRNAs, resulting in significant reduction of the targeted protein levels. 2190 miR-128 hsa-miR-128-3p,hsa-miR-1285-5p MIMAT0000424,MIMAT0005876 miRNA H3F3B apoptosis down Homo sapiens head and neck squamous cell carcinoma 25764126 9606 3021 H3.3B HGNC:4765|MIM:601058|Ensembl:ENSG00000132475|HPRD:03036|Vega:OTTHUMG00000179842 17 17q25.1 H3 histone, family 3B (H3.3B) protein-coding H3 histone, family 3B (H3.3B) Functions of MiRNA-128 on the Regulation of Head and Neck Squamous Cell Carcinoma Growth and Apoptosis. miRNA-128 was able to bind with the 3'-untranslated regions of BMI-1, BAG-2, BAX, H3f3b, and Paip2 mRNAs, resulting in significant reduction of the targeted protein levels. 2191 miR-128 hsa-miR-128-3p,hsa-miR-1285-5p MIMAT0000424,MIMAT0005876 miRNA PAIP2 apoptosis down Homo sapiens head and neck squamous cell carcinoma 25764126 9606 51247 PAIP-2|PAIP2A HGNC:17970|MIM:605604|Ensembl:ENSG00000120727|HPRD:05726|Vega:OTTHUMG00000129227 5 5q31.2 poly(A) binding protein interacting protein 2 protein-coding poly(A) binding protein interacting protein 2 Functions of MiRNA-128 on the Regulation of Head and Neck Squamous Cell Carcinoma Growth and Apoptosis. miRNA-128 was able to bind with the 3'-untranslated regions of BMI-1, BAG-2, BAX, H3f3b, and Paip2 mRNAs, resulting in significant reduction of the targeted protein levels. 2192 miR-128 hsa-miR-128-3p,hsa-miR-1285-5p MIMAT0000424,MIMAT0005876 miRNA PTEN apoptosis down Homo sapiens osteosarcoma 25246803 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog Abnormal expression of micro-ribonucleic acid (miRNA [miR])-128 has been observed in various human cancer types, and its validated target genes are implicated in cancer-related cellular processes, such as cell proliferation,differentiation, and apoptosis. Especially, it has been demonstrated that miR-128 may play an important role in the proliferation of human osteosarcoma cells in vitro by directly inhibiting PTEN. 2193 miR-129-2 hsa-miR-129-5p,hsa-miR-129-2-3p MIMAT0004548,MIMAT0004605 miRNA HMGB1 apoptosis down Homo sapiens glioma cells 25772485 9606 3146 HMG1|HMG3|SBP-1 HGNC:4983|MIM:163905|Ensembl:ENSG00000189403|HPRD:01228|Vega:OTTHUMG00000016670 13 13q12 high mobility group box 1 protein-coding high mobility group box 1 In vitro cell growth, apoptosis, cell migration,and invasion assays revealed that miR-129-2 functions as a tumor suppressor in glioma cells. Luciferase reporter assay found that miR-129-2 could directly target high-mobility group box 1 (HMGB1) and inhibit its expression in glioma cells. 2194 miR-133a hsa-miR-133a-3p,hsa-miR-133a-5p MIMAT0000427,MIMAT0026478 miRNA CASP9 apoptosis down Homo sapiens 21406115 9606 842 APAF-3|APAF3|ICE-LAP6|MCH6|PPP1R56 HGNC:1511|MIM:602234|Ensembl:ENSG00000132906|HPRD:03756|Vega:OTTHUMG00000002256 1 1p36.21 caspase 9, apoptosis-related cysteine peptidase protein-coding caspase 9, apoptosis-related cysteine peptidase Myocardial-specific miR-1 and miR-133a may play an important role in IPost protection by regulating apoptosis-related genes. MiR-133a may attenuate apoptosis of myocardiocytes by targeting CASP9. 2195 miR-133a hsa-miR-133a-3p,hsa-miR-133a-5p MIMAT0000427,MIMAT0026478 miRNA PNP apoptosis down Homo sapiens maxillary sinus squamous cell carcinoma 21701775 9606 4860 NP|PRO1837|PUNP HGNC:7892|MIM:164050|HPRD:01247 14 14q13.1 purine nucleoside phosphorylase protein-coding purine nucleoside phosphorylase Restoration of downregulated miRNAs (miR-1 or miR-133a) in cancer cells revealed that both miRNAs significantly inhibited cancer cell proliferation and induced cell apoptosis. Molecular target identification of these miRNAs showed that transgelin 2 (TAGLN2) and purine nucleoside phosphorylase (PNP) were regulated by miR-1 and miR-133a. 2196 miR-133a hsa-miR-133a-3p,hsa-miR-133a-5p MIMAT0000427,MIMAT0026478 miRNA TAGLN2 apoptosis down Homo sapiens maxillary sinus squamous cell carcinoma 21701775 9606 8407 HA1756 HGNC:11554|MIM:604634|Ensembl:ENSG00000158710|HPRD:06864|Vega:OTTHUMG00000022793 1 1q21-q25 transgelin 2 protein-coding transgelin 2 Restoration of downregulated miRNAs (miR-1 or miR-133a) in cancer cells revealed that both miRNAs significantly inhibited cancer cell proliferation and induced cell apoptosis. Molecular target identification of these miRNAs showed that transgelin 2 (TAGLN2) and purine nucleoside phosphorylase (PNP) were regulated by miR-1 and miR-133a. 2197 miR-14 hsa-miR-142-5p,hsa-miR-142-3p MIMAT0000433,MIMAT0000434 miRNA apoptosis Homo sapiens 18232304 9606 In this review, we will discuss the function of miRNAs that regulate cell proliferation and apoptosis. Antiapoptotic miRNAs include the miRNAs of the miR-17 cluster, miR-21, bantam and miR-14, Proapoptotic miRNAs include let-7, miR-15a and miR-16. 2198 miR-143 hsa-miR-143-3p,hsa-miR-143-5p MIMAT0000435,MIMAT0004599 miRNA apoptosis Homo sapiens colon cancer 21901135 9606 Our results suggest that reduced tumor volume in Over-143 versus Empty xenografts may result from increased apoptosis and decreased proliferation induced by miR-143. 2199 miR-146a hsa-miR-146a-5p,hsa-miR-146a-3p MIMAT0000449,MIMAT0004608 miRNA SMAD4 apoptosis down Homo sapiens hepatocellular carcinoma 21982769 9606 4089 DPC4|JIP|MADH4|MYHRS HGNC:6770|MIM:600993|Ensembl:ENSG00000141646|HPRD:02995|Vega:OTTHUMG00000132696 18 18q21.1 SMAD family member 4 protein-coding SMAD family member 4 MiR-146a decreased the sensitivity to IFN-¦Á through the suppression of apoptosis. Further experiments showed that miR-146a-related resistance to IFN-¦Á was mediated through SMAD4. 2200 miR-146a hsa-miR-146a-5p,hsa-miR-146a-3p MIMAT0000449,MIMAT0004608 miRNA SMAD4 apoptosis down Homo sapiens osteoarthritis 22507670 9606 4089 DPC4|JIP|MADH4|MYHRS HGNC:6770|MIM:600993|Ensembl:ENSG00000141646|HPRD:02995|Vega:OTTHUMG00000132696 18 18q21.1 SMAD family member 4 protein-coding SMAD family member 4 Smad4, a common mediator of the TGF-¦Â pathway, is identified as a direct target of miR-146a by harboring a miR-146a binding sequence in the 3'-UTR region of its mRNA.Expression of miR-146a led to a reduction of cellular responsiveness to TGF-¦Â and an increase of apoptosis rate in chondrocytes. 2201 miR-149 hsa-miR-149-3p MIMAT0004609 miRNA apoptosis Homo sapiens dilated cardiomyopathy 25361207 9606 We showed that individual silencing of 7 out of 8 significantly down-regulated miRNAs (mir-1, -29c, -30c, -30d, -149, -486, -499) led to a strong apoptotic phenotype in cell culture, suggesting they repress pro-apoptotic factors. 2202 miR-150 hsa-miR-150-5p,hsa-miR-150-3p MIMAT0000451,MIMAT0004610 miRNA MYB apoptosis down Homo sapiens hepatocellular carcinoma 22025269 9606 4602 Cmyb|c-myb|c-myb_CDS|efg HGNC:7545|MIM:189990|Ensembl:ENSG00000118513|HPRD:01810|Vega:OTTHUMG00000015629 6 6q22-q23 v-myb avian myeloblastosis viral oncogene homolog protein-coding v-myb avian myeloblastosis viral oncogene homolog We also show that miR-150 interacts with the 3'UTR of c-Myb mRNA and overexpression of miR-150 downregulates c-Myb protein levels.In addition, overexpression of miR-150 induces cell cycle arrest and apoptosis in CD133+ cells. 2203 miR-152 hsa-miR-152-3p,hsa-miR-152-5p MIMAT0000438,MIMAT0026479 miRNA DNMT1 apoptosis down Homo sapiens myeloma 25330074 9606 1786 ADCADN|AIM|CXXC9|DNMT|HSN1E|MCMT HGNC:2976|MIM:126375|Ensembl:ENSG00000130816|HPRD:00532|Vega:OTTHUMG00000180397 19 19p13.2 DNA (cytosine-5-)-methyltransferase 1 protein-coding DNA (cytosine-5-)-methyltransferase 1 The effects of these miRNAs in modulating MM cell apoptosis was also investigated; re-expression of miR-152, -10b-5p and miR-34c-3p mimics induced cleavage of PARP- and caspase-9 and -3, compared to normal control-transfected cells.DNA-methyltransferase 1 (DNMT1), a predicted target of miR-152;Enhanced expression of miR-152 induced a significant reduction of DNMT1 and E2F3 expression. 2204 miR-152 hsa-miR-152-3p,hsa-miR-152-5p MIMAT0000438,MIMAT0026479 miRNA E2F3 apoptosis down Homo sapiens myeloma 25330074 9606 1871 E2F-3 HGNC:3115|MIM:600427|Ensembl:ENSG00000112242|HPRD:02693|Vega:OTTHUMG00000016389 6 6p22 E2F transcription factor 3 protein-coding E2F transcription factor 3 The effects of these miRNAs in modulating MM cell apoptosis was also investigated; re-expression of miR-152, -10b-5p and miR-34c-3p mimics induced cleavage of PARP- and caspase-9 and -3, compared to normal control-transfected cells.E2F transcription factor 3 (E2F3), predicted target of both miR-152 and miR-10b-5p were examined in MM cells,In addition, E2F3 were significantly increased after miR-10b-5p mimic transfection 2205 miR-155 hsa-miR-155-5p,hsa-miR-155-3p MIMAT0000646,MIMAT0004658 miRNA BCL2 apoptosis down Homo sapiens 22139839 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 We suggest that miR-155 and miR-125b, which are induced by CD154 and stromal cell signals, contribute to regulating proliferation and that BCL2 is one of their target mRNAs. 2206 miR-155 hsa-miR-155-5p,hsa-miR-155-3p MIMAT0000646,MIMAT0004658 miRNA MAPK3 apoptosis down Homo sapiens HSC 25142507 9606 5595 ERK-1|ERK1|ERT2|HS44KDAP|HUMKER1A|P44ERK1|P44MAPK|PRKM3|p44-ERK1|p44-MAPK HGNC:6877|MIM:601795|Ensembl:ENSG00000102882|HPRD:03479|Vega:OTTHUMG00000132149 16 16p11.2 mitogen-activated protein kinase 3 protein-coding mitogen-activated protein kinase 3 Inhibiting miR-155 expression could stimulate the EMT state and ERK1 pathway activity, thus contributing to HSC activation. Forced miR-155 expression markedly decreased the mesenchymal markers and phosphorylated ERK1 level, and enhanced E-cadherin expression, leading to the synchronous inhibitory effect on EMT and ERK1 pathway and inducing HSC apoptosis. 2207 miR-155 hsa-miR-155-5p,hsa-miR-155-3p MIMAT0000646,MIMAT0004658 miRNA apoptosis Homo sapiens 25352952 9606 miR-155 is an oncogenic miRNA which regulates many cellular pathways, designating it as a multifaceted regulator of proliferation, chemo-resistance, and apoptosis. 2208 miR-155 hsa-miR-155-5p,hsa-miR-155-3p MIMAT0000646,MIMAT0004658 miRNA apoptosis Homo sapiens hematopoietic stem and progenitor cells 25730818 9606 Cell cycle analyses showed a higher frequency of G-CSFRIV+ cells in S and G2/M phase. Also, apoptosis rates were significantly lower in G-CSFRIV+ HSPCs. These findings were shown to be associated with a sustained Stat5 activation and elevated miR-155 expression. 2209 miR-15a hsa-miR-15a-5p,hsa-miR-15a-3p MIMAT0000068,MIMAT0004488 miRNA BCL2 apoptosis down Homo sapiens tumor cell 17554199 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Other p53-induced miRNAs identified here may also have tumor suppressive potential as they are known to suppress the anti-apoptotic factor Bcl2 (miR-15a/16) and the oncogenes RAS and HMGA2 (let-7a). 2210 miR-15a hsa-miR-15a-5p,hsa-miR-15a-3p MIMAT0000068,MIMAT0004488 miRNA SNCG apoptosis down Homo sapiens Homo sapiens 25169552 9606 6623 BCSG1|SR HGNC:11141|MIM:602998|Ensembl:ENSG00000173267|HPRD:04297|Vega:OTTHUMG00000018656 10 10q23.2-q23.3 synuclein, gamma (breast cancer-specific protein 1) protein-coding synuclein, gamma (breast cancer-specific protein 1) Ectopic expression of miR-15a promoted proliferation and suppressed apoptosis in vivo.Further studies indicated that miR-15a may directly interact with the 3'-untranslated region (3'-UTR) of SNCG mRNA, downregulating its mRNA and protein expression levels. 2211 miR-15a hsa-miR-15a-5p,hsa-miR-15a-3p MIMAT0000068,MIMAT0004488 miRNA TLR1 apoptosis down Homo sapiens non-small cell lung cancer 25442346 9606 7096 CD281|TIL|TIL. LPRS5|rsc786 HGNC:11847|MIM:601194|Ensembl:ENSG00000174125|HPRD:03119|Vega:OTTHUMG00000160413 4 4p14 toll-like receptor 1 protein-coding toll-like receptor 1 We corroborated that miR-15a/16 specifically bound to TLR1 3'UTR and inhibited the expression of TLR1 in H358 and A549 cells.In addition, overexpression of miR-15a/16 inhibited survival capability and increased radiation-induced apoptosis. 2212 miR-15a hsa-miR-15a-5p,hsa-miR-15a-3p,hsa-miR-15b-5p,hsa-miR-15b-3p MIMAT0000068,MIMAT0004488,MIMAT0000417,MIMAT000458 miRNA apoptosis Homo sapiens 18232304 9606 In this review, we will discuss the function of miRNAs that regulate cell proliferation and apoptosis. Antiapoptotic miRNAs include the miRNAs of the miR-17 cluster, miR-21, bantam and miR-14, Proapoptotic miRNAs include let-7, miR-15a and miR-16. 2213 miR-15a hsa-miR-15a-5p,hsa-miR-15a-3p MIMAT0000068,MIMAT0004488 miRNA apoptosis Homo sapiens cancer cells of advanced prostate tumors 18931683 9606 Conversely, reconstitution of miR-15a and miR-16-1 expression results in growth arrest, apoptosis and marked regression of prostate tumor xenografts. 2214 miR-15b hsa-miR-15b-5p,hsa-miR-15b-3p MIMAT0000417,MIMAT0004586 miRNA BCL2 apoptosis Homo sapiens gastric cancer cells 18449891 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Taken together, our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2. 2215 miR-15b hsa-miR-15b-5p,hsa-miR-15b-3p MIMAT0000417,MIMAT0004586 miRNA BCL2 apoptosis down Homo sapiens liver 22374434 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Our in vitro data demonstrated that miR-15b and/or miR-16 regulated BCL2 at the protein level. Inhibition of miR-15b and/or miR-16 reduced hepatic apoptosis and TNF production. 2216 miR-16 hsa-miR-16-5p,hsa-miR-16-1-3p,hsa-miR-16-2-3p MIMAT0000069,MIMAT0004489,MIMAT0004518 miRNA BCL2 apoptosis down Homo sapiens tumor cell 17554199 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Other p53-induced miRNAs identified here may also have tumor suppressive potential as they are known to suppress the anti-apoptotic factor Bcl2 (miR-15a/16) and the oncogenes RAS and HMGA2 (let-7a). 2217 miR-16 hsa-miR-16-5p,hsa-miR-16-1-3p,hsa-miR-16-2-3p MIMAT0000069,MIMAT0004489,MIMAT0004518 miRNA BCL2 apoptosis Homo sapiens gastric cancer cells 18449891 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Taken together, our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2. 2218 miR-16 hsa-miR-16-5p,hsa-miR-16-1-3p,hsa-miR-16-2-3p MIMAT0000069,MIMAT0004489,MIMAT0004518 miRNA BCL2 apoptosis down Homo sapiens liver 22374434 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Our in vitro data demonstrated that miR-15b and/or miR-16 regulated BCL2 at the protein level. Inhibition of miR-15b and/or miR-16 reduced hepatic apoptosis and TNF production. 2219 miR-16 hsa-miR-16-5p,hsa-miR-16-1-3p,hsa-miR-16-2-3p MIMAT0000069,MIMAT0004489,MIMAT0004518 miRNA BCL2 apoptosis down Homo sapiens lung cancer cells 25435430 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 MiR-17 overexpression reducedcytoprotective autophagy by targeting Beclin-1, whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2. 2220 miR-16 hsa-miR-16-5p,hsa-miR-16-1-3p,hsa-miR-16-2-3p MIMAT0000069,MIMAT0004489,MIMAT0004518 miRNA BCL2 apoptosis down Homo sapiens MCF-7 cell line 25672252 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 MiR-16, which is located in 13q14 chromosome, plays critical roles as a tumor suppressor by targeting several oncogenes which regulate cell cycle and apoptosis. We showed that the miR-16 overexpression reduces Cyclin D1 and BCL2 at messenger RNA (mRNA) and protein levels in MCF-7 cell line. 2221 miR-16 hsa-miR-16-5p,hsa-miR-16-1-3p,hsa-miR-16-2-3p MIMAT0000069,MIMAT0004489,MIMAT0004518 miRNA CCND1 apoptosis down Homo sapiens MCF-7 cell line 25672252 9606 595 BCL1|D11S287E|PRAD1|U21B31 HGNC:1582|MIM:168461|Ensembl:ENSG00000110092|HPRD:01346|Vega:OTTHUMG00000167877 11 11q13 cyclin D1 protein-coding cyclin D1 MiR-16, which is located in 13q14 chromosome, plays critical roles as a tumor suppressor by targeting several oncogenes which regulate cell cycle and apoptosis. We showed that the miR-16 overexpression reduces Cyclin D1 and BCL2 at messenger RNA (mRNA) and protein levels in MCF-7 cell line. 2222 miR-16 hsa-miR-16-5p,hsa-miR-16-1-3p,hsa-miR-16-2-3p MIMAT0000069,MIMAT0004489,MIMAT0004518 miRNA TLR1 apoptosis down Homo sapiens non-small cell lung cancer 25442346 9606 7096 CD281|TIL|TIL. LPRS5|rsc786 HGNC:11847|MIM:601194|Ensembl:ENSG00000174125|HPRD:03119|Vega:OTTHUMG00000160413 4 4p14 toll-like receptor 1 protein-coding toll-like receptor 1 We corroborated that miR-15a/16 specifically bound to TLR1 3'UTR and inhibited the expression of TLR1 in H358 and A549 cells.In addition, overexpression of miR-15a/16 inhibited survival capability and increased radiation-induced apoptosis. 2223 miR-16 hsa-miR-16-5p,hsa-miR-16-1-3p,hsa-miR-16-2-3p MIMAT0000069,MIMAT0004489,MIMAT0004518 miRNA apoptosis Homo sapiens 18232304 9606 In this review, we will discuss the function of miRNAs that regulate cell proliferation and apoptosis. Antiapoptotic miRNAs include the miRNAs of the miR-17 cluster, miR-21, bantam and miR-14, Proapoptotic miRNAs include let-7, miR-15a and miR-16. 2224 miR-16-1 hsa-miR-16-1-3p MIMAT0004489 miRNA apoptosis Homo sapiens cancer cells of advanced prostate tumors 18931683 9606 Conversely, reconstitution of miR-15a and miR-16-1 expression results in growth arrest, apoptosis and marked regression of prostate tumor xenografts. 2225 miR-17 hsa-miR-17-5p,hsa-miR-17-3p MIMAT0000070,MIMAT0000071 miRNA CDKN1A apoptosis down Homo sapiens lymphoma 21953646 9606 1026 CAP20|CDKN1|CIP1|MDA-6|P21|SDI1|WAF1|p21CIP1 HGNC:1784|MIM:116899|Ensembl:ENSG00000124762|HPRD:00298|Vega:OTTHUMG00000014603 6 6p21.2 cyclin-dependent kinase inhibitor 1A (p21, Cip1) protein-coding cyclin-dependent kinase inhibitor 1A (p21, Cip1) Alterations in the cell cycle and apoptosis pathways might contribute to their resistance to apoptosis and sustained cell cycle progression.A key player in both cell cycle arrest and apoptosis is CDKN1A, encoding p21.We showed effective targeting of the CDKN1A 3' UTR by miR-17/106b in HL cell lines in a luciferase reporter assay and up-regulation of p21 protein levels upon anti-miR-17 treatment of KM-H2 cells. 2226 miR-17 hsa-miR-17-5p,hsa-miR-17-3p MIMAT0000070,MIMAT0000071 miRNA CDKN1A apoptosis down Homo sapiens leukemia 25130806 9606 1026 CAP20|CDKN1|CIP1|MDA-6|P21|SDI1|WAF1|p21CIP1 HGNC:1784|MIM:116899|Ensembl:ENSG00000124762|HPRD:00298|Vega:OTTHUMG00000014603 6 6p21.2 cyclin-dependent kinase inhibitor 1A (p21, Cip1) protein-coding cyclin-dependent kinase inhibitor 1A (p21, Cip1) Over-expressed miR-17 and miR-20a promote cell growth and cell cycle progression, and inhibit apoptosis through negatively-regulating P21 and E2F1 after-transcriptionally. 2227 miR-17 hsa-miR-17-5p,hsa-miR-17-3p MIMAT0000070,MIMAT0000071 miRNA apoptosis Homo sapiens 18232304 9606 In this review, we will discuss the function of miRNAs that regulate cell proliferation and apoptosis. Antiapoptotic miRNAs include the miRNAs of the miR-17 cluster, miR-21, bantam and miR-14, Proapoptotic miRNAs include let-7, miR-15a and miR-16. 2228 miR-17-3p hsa-miR-17-3p MIMAT0000071 miRNA BCL2 apoptosis up Homo sapiens B-cell 18941111 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Recent studies have shown that miR-17-92 down-regulates the proapoptotic protein Bim, leading to overexpression of Bcl2, which likely plays a key role in lymphomagenesis. 2229 miR-17-3p hsa-miR-17-3p miRNA BCL2L11 apoptosis down Homo sapiens B-cell 18941111 9606 10018 BAM|BIM|BOD HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 2 2q13 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) Recent studies have shown that miR-17-92 down-regulates the proapoptotic protein Bim, leading to overexpression of Bcl2, which likely plays a key role in lymphomagenesis. 2230 miR-17-3p hsa-miR-17-3p MIMAT0000071 miRNA BCL2L11 apoptosis Homo sapiens lymphoma 22116552 9606 10018 BAM|BIM|BOD HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 2 2q13 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) We demonstrated that the protein phosphatase PHLPP2, an important negative regulator of the PI3K/AKT pathway, was a direct target of miR-17¡«92 miRNAs, in addition to PTEN and BIM. Overexpression of miR-17¡«92 activated the PI3K/AKT pathway and inhibited chemotherapy-induced apoptosis in MCL cell lines. 2231 miR-17-3p hsa-miR-17-3p MIMAT0000071 miRNA PHLPP2 apoptosis Homo sapiens lymphoma 22116552 9606 23035 PHLPPL HGNC:29149|MIM:611066|Ensembl:ENSG00000040199|HPRD:11118|Vega:OTTHUMG00000176867 16 16q22.2 PH domain and leucine rich repeat protein phosphatase 2 protein-coding PH domain and leucine rich repeat protein phosphatase 2 We demonstrated that the protein phosphatase PHLPP2, an important negative regulator of the PI3K/AKT pathway, was a direct target of miR-17¡«92 miRNAs, in addition to PTEN and BIM.Overexpression of miR-17¡«92 activated the PI3K/AKT pathway and inhibited chemotherapy-induced apoptosis in MCL cell lines. 2232 miR-17-3p hsa-miR-17-3p MIMAT0000071 miRNA PTEN apoptosis Homo sapiens lymphoma 22116552 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog We demonstrated that the protein phosphatase PHLPP2, an important negative regulator of the PI3K/AKT pathway, was a direct target of miR-17¡«92 miRNAs, in addition to PTEN and BIM.Overexpression of miR-17¡«92 activated the PI3K/AKT pathway and inhibited chemotherapy-induced apoptosis in MCL cell lines. 2233 miR-17-3p hsa-miR-17-3p MIMAT0000071 miRNA apoptosis Homo sapiens lung cancers 17384677 9606 In the present study, we show that inhibition of miR-17-5p and miR-20a with antisense oligonucleotides (ONs) can induce apoptosis selectively in lung cancer cells overexpressing miR-17-92, suggesting the possibility of 'OncomiR addiction' to expression of these miRNAs in a subset of lung cancers. 2234 miR-17-3p hsa-miR-17-3p MIMAT0000071 miRNA apoptosis Homo sapiens heart, lungs, and immune system. 18423194 9606 MicroRNAs (miRNAs) encoded by the miR-17-92 cluster and its paralogs are known to act as oncogenes. Expression of these miRNAs promotes cell proliferation, suppresses apoptosis of cancer cells, and induces tumor angiogenesis. 2235 miR-17-3p hsa-miR-17-3p MIMAT0000071 miRNA apoptosis Homo sapiens gastrointestinal and other tumors 18922889 9606 The miR-106b-25 and miR-17-92 clusters are emerging as key modulators of TGFbeta signaling in gastrointestinal and other tumors, interfering with cell cycle arrest and apoptosis when overexpressed in cancer cells. 2236 miR-17-5p hsa-miR-17-5p MIMAT0000070 miRNA BCL2 apoptosis up Homo sapiens B-cell 18941111 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Recent studies have shown that miR-17-92 down-regulates the proapoptotic protein Bim, leading to overexpression of Bcl2, which likely plays a key role in lymphomagenesis. 2237 miR-17-5p hsa-miR-17-5p MIMAT0000070 miRNA BCL2L11 apoptosis Homo sapiens SH-EP and SK-N-AS human neuroblastoma cell lines 18493594 9606 10018 BAM|BIM|BOD HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 2 2q13 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) In vitro or in vivo treatment with antagomir-17-5p abolishes the growth of MYCN-amplified and therapy-resistant neuroblastoma through p21 and BIM upmodulation, leading to cell cycling blockade and activation of apoptosis, respectively. 2238 miR-17-5p hsa-miR-17-5p miRNA BCL2L11 apoptosis down Homo sapiens B-cell 18941111 9606 10018 BAM|BIM|BOD HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 2 2q13 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) Recent studies have shown that miR-17-92 down-regulates the proapoptotic protein Bim, leading to overexpression of Bcl2, which likely plays a key role in lymphomagenesis. 2239 miR-17-5p hsa-miR-17-5p MIMAT0000070 miRNA BCL2L11 apoptosis down Homo sapiens kidney 21546576 9606 10018 BAM|BIM|BOD HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 2 2q13 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) Here, we found that the loss of miRNAs in nephron progenitors results in a premature depletion of this population during kidney development. Increased apoptosis and expression of the pro-apoptotic protein Bim accompanied this depletion. Profiling of miRNA expression during nephrogenesis identified several highly expressed miRNAs (miR-10a, miR-106b, miR-17-5p) in nephron progenitors that are either known or predicted to target Bim. 2240 miR-17-5p hsa-miR-17-5p MIMAT0000070 miRNA BCL2L11 apoptosis Homo sapiens lymphoma 22116552 9606 10018 BAM|BIM|BOD HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 2 2q13 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) We demonstrated that the protein phosphatase PHLPP2, an important negative regulator of the PI3K/AKT pathway, was a direct target of miR-17¡«92 miRNAs, in addition to PTEN and BIM.Overexpression of miR-17¡«92 activated the PI3K/AKT pathway and inhibited chemotherapy-induced apoptosis in MCL cell lines. 2241 miR-17-5p hsa-miR-17-5p MIMAT0000070 miRNA CDKN1B apoptosis Homo sapiens SH-EP and SK-N-AS human neuroblastoma cell lines 18493594 9606 1027 CDKN4|KIP1|MEN1B|MEN4|P27KIP1 HGNC:1785|MIM:600778|Ensembl:ENSG00000111276|HPRD:02867|Vega:OTTHUMG00000149914 12 12p13.1-p12 cyclin-dependent kinase inhibitor 1B (p27, Kip1) protein-coding cyclin-dependent kinase inhibitor 1B (p27, Kip1) In vitro or in vivo treatment with antagomir-17-5p abolishes the growth of MYCN-amplified and therapy-resistant neuroblastoma through p21 and BIM upmodulation, leading to cell cycling blockade and activation of apoptosis, respectively. 2242 miR-17-5p hsa-miR-17-5p MIMAT0000070 miRNA PHLPP2 apoptosis Homo sapiens lymphoma 22116552 9606 23035 PHLPPL HGNC:29149|MIM:611066|Ensembl:ENSG00000040199|HPRD:11118|Vega:OTTHUMG00000176867 16 16q22.2 PH domain and leucine rich repeat protein phosphatase 2 protein-coding PH domain and leucine rich repeat protein phosphatase 2 We demonstrated that the protein phosphatase PHLPP2, an important negative regulator of the PI3K/AKT pathway, was a direct target of miR-17¡«92 miRNAs, in addition to PTEN and BIM.Overexpression of miR-17¡«92 activated the PI3K/AKT pathway and inhibited chemotherapy-induced apoptosis in MCL cell lines. 2243 miR-17-5p hsa-miR-17-5p MIMAT0000070 miRNA PTEN apoptosis Homo sapiens lymphoma 22116552 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog We demonstrated that the protein phosphatase PHLPP2, an important negative regulator of the PI3K/AKT pathway, was a direct target of miR-17¡«92 miRNAs, in addition to PTEN and BIM.Overexpression of miR-17¡«92 activated the PI3K/AKT pathway and inhibited chemotherapy-induced apoptosis in MCL cell lines. 2244 miR-17-5p hsa-miR-17-5p MIMAT0000070 miRNA apoptosis Homo sapiens lung cancers 17384677 9606 In the present study, we show that inhibition of miR-17-5p and miR-20a with antisense oligonucleotides (ONs) can induce apoptosis selectively in lung cancer cells overexpressing miR-17-92, suggesting the possibility of 'OncomiR addiction' to expression of these miRNAs in a subset of lung cancers. 2245 miR-17-5p hsa-miR-17-5p MIMAT0000070 miRNA apoptosis Homo sapiens heart, lungs, and immune system. 18423194 9606 MicroRNAs (miRNAs) encoded by the miR-17-92 cluster and its paralogs are known to act as oncogenes. Expression of these miRNAs promotes cell proliferation, suppresses apoptosis of cancer cells, and induces tumor angiogenesis. 2246 miR-17-5p hsa-miR-17-5p MIMAT0000070 miRNA apoptosis Homo sapiens gastrointestinal and other tumors 18922889 9606 The miR-106b-25 and miR-17-92 clusters are emerging as key modulators of TGFbeta signaling in gastrointestinal and other tumors, interfering with cell cycle arrest and apoptosis when overexpressed in cancer cells. 2247 miR-181a hsa-miR-181a-5p,hsa-miR-181a-3p,hsa-miR-181a-2-3p MIMAT0000256,MIMAT0000270,MIMAT0004558 miRNA RALA apoptosis down Homo sapiens chronic myelogenous leukemia 22442671 9606 5898 RAL HGNC:9839|MIM:179550|Ensembl:ENSG00000006451|HPRD:01549|Vega:OTTHUMG00000128775 7 7p15-p13 v-ral simian leukemia viral oncogene homolog A (ras related) protein-coding v-ral simian leukemia viral oncogene homolog A (ras related) Luciferase reporter and Western blot assays confirmed that RalA is a direct target of miR-181a. overexpression of miR-181a effectively suppresses cell growth and induces G2-phase arrest and apoptosis partially by targeting RalA in leukemic K562 cells. 2248 miR-181a hsa-miR-181a-5p,hsa-miR-181a-3p MIMAT0000256,MIMAT0000270 miRNA apoptosis Homo sapiens glioma cells 18710654 9606 Our studies showed that hsa-miR-181a and hsa-miR-181b functioned as tumor suppressors which triggered growth inhibition, induced apoptosis and inhibited invasion in glioma cells. 2249 miR-181b hsa-miR-181b-5p,hsa-miR-181b-3p MIMAT0000257,MIMAT0022692 miRNA apoptosis Homo sapiens glioma cells 18710654 9606 Our studies showed that hsa-miR-181a and hsa-miR-181b functioned as tumor suppressors which triggered growth inhibition, induced apoptosis and inhibited invasion in glioma cells. 2250 miR-182 hsa-miR-182-5p,hsa-miR-182-3p MIMAT0000259,MIMAT0000260 miRNA AKT1 apoptosis down Homo sapiens Type 2 diabetes 25530976 9606 207 AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA HGNC:391|MIM:164730|Ensembl:ENSG00000142208|HPRD:01261|Vega:OTTHUMG00000170795 14 14q32.32 v-akt murine thymoma viral oncogene homolog 1 protein-coding v-akt murine thymoma viral oncogene homolog 1 Among them, miR-182 related to the insulin resistance by modulating FOXO1 and PI3K/AKT cascade and had the greatest copy number in the whole blood.miR-182 might regulate the processes of both cell proliferation and apoptosis that play crucial role in determining the cells' fate. 2251 miR-182 hsa-miR-182-5p,hsa-miR-182-3p MIMAT0000259,MIMAT0000260 miRNA FOXO1 apoptosis down Homo sapiens Type 2 diabetes 25530976 9606 2308 FKH1|FKHR|FOXO1A HGNC:3819|MIM:136533|Ensembl:ENSG00000150907|HPRD:00645|Vega:OTTHUMG00000016775 13 13q14.1 forkhead box O1 protein-coding forkhead box O1 Among them, miR-182 related to the insulin resistance by modulating FOXO1 and PI3K/AKT cascade and had the greatest copy number in the whole blood.miR-182 might regulate the processes of both cell proliferation and apoptosis that play crucial role in determining the cells' fate. 2252 miR-182 hsa-miR-182-5p,hsa-miR-182-3p MIMAT0000259,MIMAT0000260 miRNA apoptosis down Homo sapiens Type 2 diabetes 25530976 9606 protein coding Among them, miR-182 related to the insulin resistance by modulating FOXO1 and PI3K/AKT cascade and had the greatest copy number in the whole blood.miR-182 might regulate the processes of both cell proliferation and apoptosis that play crucial role in determining the cells' fate. 2253 miR-182-5p hsa-miR-182-5p MIMAT0000259 miRNA apoptosis Homo sapiens neuroblastoma 25762502 9606 Overexpression of miR-182-5p promoted apoptosis in some neuroblastoma cell lines and induced neuronal differentiation of NGP cells. 2254 miR-183 hsa-miR-183-5p,hsa-miR-183-3p MIMAT0000261,MIMAT0004560 miRNA PDCD4 apoptosis down Homo sapiens EC9706 25518924 9606 27250 H731 HGNC:8763|MIM:608610|Ensembl:ENSG00000150593|HPRD:10549|Vega:OTTHUMG00000019048 10 10q24 programmed cell death 4 (neoplastic transformation inhibitor) protein-coding programmed cell death 4 (neoplastic transformation inhibitor) Cell culture results showed that miR-183 inhibited apoptosis,enhanced cell proliferation,and accelerated G1/S transition.Western blot analysis showed that the expression of programmed cell death 4 (PDCD4), which was predicted as the target gene of miR-183 by microarray profiling and bioinformatics predictions, decreased when miR-183 was over-expressed. 2255 miR-184 hsa-miR-184 MIMAT0000454 miRNA MYC apoptosis up Homo sapiens Squamous Cell 18451220 9606 4609 MRTL|MYCC|bHLHe39|c-Myc HGNC:7553|MIM:190080|Ensembl:ENSG00000136997|HPRD:01818|Vega:OTTHUMG00000128475 8 8q24.21 v-myc avian myelocytomatosis viral oncogene homolog protein-coding v-myc avian myelocytomatosis viral oncogene homolog Inhibition of miR-184 in tongue SCC cell lines could reduce cell proliferation rate. Down-regulation of c-Myc was observed in two cell lines in response to miR-184 inhibitor. Suppressing miR-184 could induce apoptosis in all three cell lines. Overexpression of miR-184 might play an oncogenic role in the antiapoptotic and proliferative processes of tongue SCC. 2256 miR-184 hsa-miR-184 MIMAT0000454 miRNA TNFAIP2 apoptosis Homo sapiens head and neck 21934093 9606 7127 B94|EXOC3L3 HGNC:11895|MIM:603300|Ensembl:ENSG00000185215|HPRD:04487|Vega:OTTHUMG00000171890 14 14q32 tumor necrosis factor, alpha-induced protein 2 protein-coding tumor necrosis factor, alpha-induced protein 2 Although the role of TNFAIP2 is still unclear, it is an important gene involved in apoptosis, Additionally, we identified that the rs8126 T > C SNP is within the miR-184 seed binding region in the 3' UTR of TNFAIP2. 2257 miR-184 hsa-miR-184 MIMAT0000454 miRNA apoptosis Homo sapiens renal cance 25667660 9606 Our studies revealed that miR-184 mimic significantly inhibits cell migration, suppresses cell proliferation and induces renal cancer cell apoptosis in vitro when compared with the negative control 2258 miR-18a hsa-miR-18a-5p,hsa-miR-18a-3p MIMAT0000072,MIMAT0002891 miRNA BCL2 apoptosis up Homo sapiens B-cell 18941111 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Recent studies have shown that miR-17-92 down-regulates the proapoptotic protein Bim, leading to overexpression of Bcl2, which likely plays a key role in lymphomagenesis. 2259 miR-18a hsa-miR-18a-5p,hsa-miR-18a-3p miRNA BCL2L11 apoptosis down Homo sapiens B-cell 18941111 9606 10018 BAM|BIM|BOD HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 2 2q13 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) Recent studies have shown that miR-17-92 down-regulates the proapoptotic protein Bim, leading to overexpression of Bcl2, which likely plays a key role in lymphomagenesis. 2260 miR-18a hsa-miR-18a-5p,hsa-miR-18a-3p MIMAT0000072,MIMAT0002891 miRNA BCL2L11 apoptosis Homo sapiens lymphoma 22116552 9606 10018 BAM|BIM|BOD HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 2 2q13 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) We demonstrated that the protein phosphatase PHLPP2, an important negative regulator of the PI3K/AKT pathway, was a direct target of miR-17¡«92 miRNAs, in addition to PTEN and BIM.Overexpression of miR-17¡«92 activated the PI3K/AKT pathway and inhibited chemotherapy-induced apoptosis in MCL cell lines. 2261 miR-18a hsa-miR-18a-5p,hsa-miR-18a-3p MIMAT0000072,MIMAT0002891 miRNA HNRNPA1 apoptosis down Homo sapiens colon cancer cell 24166503 9606 3178 ALS19|ALS20|HNRPA1|HNRPA1L3|IBMPFD3|hnRNP A1|hnRNP-A1 HGNC:5031|MIM:164017|Ensembl:ENSG00000135486|HPRD:01242|Vega:OTTHUMG00000169702 12 12q13.1 heterogeneous nuclear ribonucleoprotein A1 protein-coding heterogeneous nuclear ribonucleoprotein A1 An immunocytochemical study of hnRNP A1 and LC3-II and the inhibition of autophagy by 3-methyladenine and ATG7, p62 and BAG3 siRNA showed that miR-18a and hnRNP A1 formed a complex that was degraded through the autophagolysosomal pathway. This is the first report showing a novel function of a miR in the autophagolysosomal degradation of an oncogenic protein resulting from the creation of a complex consisting of the miR and a RNA-binding protein, which suppressed cancer progression. 2262 miR-18a hsa-miR-18a-5p,hsa-miR-18a-3p MIMAT0000072,MIMAT0002891 miRNA PHLPP2 apoptosis Homo sapiens lymphoma 22116552 9606 23035 PHLPPL HGNC:29149|MIM:611066|Ensembl:ENSG00000040199|HPRD:11118|Vega:OTTHUMG00000176867 16 16q22.2 PH domain and leucine rich repeat protein phosphatase 2 protein-coding PH domain and leucine rich repeat protein phosphatase 2 We demonstrated that the protein phosphatase PHLPP2, an important negative regulator of the PI3K/AKT pathway, was a direct target of miR-17¡«92 miRNAs, in addition to PTEN and BIM.Overexpression of miR-17¡«92 activated the PI3K/AKT pathway and inhibited chemotherapy-induced apoptosis in MCL cell lines. 2263 miR-18a hsa-miR-18a-5p,hsa-miR-18a-3p MIMAT0000072,MIMAT0002891 miRNA PTEN apoptosis Homo sapiens lymphoma 22116552 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog We demonstrated that the protein phosphatase PHLPP2, an important negative regulator of the PI3K/AKT pathway, was a direct target of miR-17¡«92 miRNAs, in addition to PTEN and BIM.Overexpression of miR-17¡«92 activated the PI3K/AKT pathway and inhibited chemotherapy-induced apoptosis in MCL cell lines. 2264 miR-18a hsa-miR-18a-5p,hsa-miR-18a-3p MIMAT0000072,MIMAT0000072 miRNA apoptosis Homo sapiens lung cancers 17384677 9606 In the present study, we show that inhibition of miR-17-5p and miR-20a with antisense oligonucleotides (ONs) can induce apoptosis selectively in lung cancer cells overexpressing miR-17-92, suggesting the possibility of 'OncomiR addiction' to expression of these miRNAs in a subset of lung cancers. 2265 miR-18a hsa-miR-18a-5p,hsa-miR-18a-3p MIMAT0000072,MIMAT0002891 miRNA apoptosis Homo sapiens heart, lungs, and immune system. 18423194 9606 MicroRNAs (miRNAs) encoded by the miR-17-92 cluster and its paralogs are known to act as oncogenes. Expression of these miRNAs promotes cell proliferation, suppresses apoptosis of cancer cells, and induces tumor angiogenesis. 2266 miR-18a hsa-miR-18a-5p,hsa-miR-18a-3p,hsa-miR-18b-5p MIMAT0000072,MIMAT0002891 miRNA apoptosis Homo sapiens gastrointestinal and other tumors 18922889 9606 The miR-106b-25 and miR-17-92 clusters are emerging as key modulators of TGFbeta signaling in gastrointestinal and other tumors, interfering with cell cycle arrest and apoptosis when overexpressed in cancer cells. 2267 miR-18b hsa-miR-18b-5p,hsa-miR-18b-3p MIMAT0001412,MIMAT0004751 miRNA FAS apoptosis up Homo sapiens thymic cell 25753120 9606 355 ALPS1A|APO-1|APT1|CD95|FAS1|FASTM|TNFRSF6 HGNC:11920|MIM:134637|Ensembl:ENSG00000026103|HPRD:00609|Vega:OTTHUMG00000018701 10 10q24.1 Fas cell surface death receptor protein-coding Fas cell surface death receptor Transfection studies confirmed that DES-mediated downregulation of miR-18b and miR-23a led to increased FasL and Fas expression. These data demonstrated that prenatal DES exposure can cause alterations in miRs, leading to changes in the gene expression, specifically, miR-mediated increased expression in FasL and Fas causing apoptosis and thymic atrophy. 2268 miR-18b hsa-miR-18b-5p,hsa-miR-18b-3p MIMAT0001412,MIMAT0004751 miRNA FASLG apoptosis up Homo sapiens thymic cell 25753120 9606 356 ALPS1B|APT1LG1|APTL|CD178|CD95-L|CD95L|FASL|TNFSF6 HGNC:11936|MIM:134638|Ensembl:ENSG00000117560|HPRD:00610|Vega:OTTHUMG00000034841 1 1q23 Fas ligand (TNF superfamily, member 6) protein-coding Fas ligand (TNF superfamily, member 6) Transfection studies confirmed that DES-mediated downregulation of miR-18b and miR-23a led to increased FasL and Fas expression. These data demonstrated that prenatal DES exposure can cause alterations in miRs, leading to changes in the gene expression, specifically, miR-mediated increased expression in FasL and Fas causing apoptosis and thymic atrophy. 2269 miR-19 hsa-miR-19a-5p,hsa-miR-19a-3p,hsa-miR-19b-1-5p,hsa-miR-19b-2-5p,hsa-miR-19b-3p MIMAT0004490,MIMAT0000073,MIMAT0004491,MIMAT0004492,MIMAT0000074 miRNA RHOB apoptosis down Homo sapiens keratinocytes 21527938 9606 388 ARH6|ARHB|MST081|MSTP081|RHOH6 HGNC:668|MIM:165370|Ensembl:ENSG00000143878|HPRD:01321|Vega:OTTHUMG00000090755 2 2p24 ras homolog family member B protein-coding ras homolog family member B However, we show that miR-19-mediated regulation of antiapoptotic RhoB expression requires the binding of human antigen R (HuR), an AU-rich element binding protein, to the 3'-untranslated region of the rhoB mRNA. 2270 miR-192-5p hsa-miR-192-5p MIMAT0000222 miRNA XIAP apoptosis down Homo sapiens H460, A427 and A549 cells 25444916 9606 331 API3|BIRC4|IAP-3|ILP1|MIHA|XLP2|hIAP-3|hIAP3 HGNC:592|MIM:300079|Ensembl:ENSG00000101966|HPRD:02094|Vega:OTTHUMG00000022336 X Xq25 X-linked inhibitor of apoptosis protein-coding X-linked inhibitor of apoptosis Taken together, this study highlights that the proapoptotic effects of curcumin depend on miR-192-5p/215 induction and the p53-miR-192-5p/215-XIAP pathway is an important therapeutic target for non-small cell lung cancer. 2271 miR-195 hsa-miR-195-5p,hsa-miR-195-3p MIMAT0000461,MIMAT0004615 miRNA BCL2 apoptosis Homo sapiens 22190509 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Mir-195 regulates a plethora of target proteins, which are involved in the cell cycle, apoptosis, proliferation. WEE1, CDK6, and Bcl-2 are confirmed target genes of miR-195 that are involved in miR-195-mediated cell-cycle and apoptosis effects. 2272 miR-195 hsa-miR-195-5p,hsa-miR-195-3p MIMAT0000461,MIMAT0004615 miRNA BCL2L2 apoptosis down Homo sapiens hepatocellular carcinoma 21947305 9606 599 BCL-W|BCL2-L-2|BCLW|PPP1R51 HGNC:995|MIM:601931|Ensembl:ENSG00000129473|HPRD:03569|Vega:OTTHUMG00000028738 14 14q11.2-q12 BCL2-like 2 protein-coding BCL2-like 2 The basal levels of the anti-apoptotic protein Bcl-w were high in BEL-7402/5-FU cells and miR-195 overexpression repressed Bcl-w protein level and inhibited the luciferase activity of a Bcl-w 3'untranslated region-based reporter construct in both BEL-7402/5-FU and BEL-7402 cells. 2273 miR-195 hsa-miR-195-5p,hsa-miR-195-3p MIMAT0000461,MIMAT0004615 miRNA CDK6 apoptosis Homo sapiens 22190509 9606 1021 PLSTIRE HGNC:1777|MIM:603368|Ensembl:ENSG00000105810|HPRD:04533|Vega:OTTHUMG00000131697 7 7q21-q22 cyclin-dependent kinase 6 protein-coding cyclin-dependent kinase 6 Mir-195 regulates a plethora of target proteins, which are involved in the cell cycle, apoptosis, proliferation. WEE1, CDK6, and Bcl-2 are confirmed target genes of miR-195 that are involved in miR-195-mediated cell-cycle and apoptosis effects. 2274 miR-195 hsa-miR-195-5p,hsa-miR-195-3p MIMAT0000461,MIMAT0004615 miRNA WEE1 apoptosis Homo sapiens 22190509 9606 7465 WEE1A|WEE1hu HGNC:12761|MIM:193525|Ensembl:ENSG00000166483|HPRD:01907|Vega:OTTHUMG00000165863 11 11p15.4 WEE1 G2 checkpoint kinase protein-coding WEE1 G2 checkpoint kinase Mir-195 regulates a plethora of target proteins, which are involved in the cell cycle, apoptosis, proliferation. WEE1, CDK6, and Bcl-2 are confirmed target genes of miR-195 that are involved in miR-195-mediated cell-cycle and apoptosis effects. 2275 miR-19a hsa-miR-19a-5p,hsa-miR-19a-3p MIMAT0004490,MIMAT0000073 miRNA BCL2 apoptosis up Homo sapiens B-cell 18941111 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Recent studies have shown that miR-17-92 down-regulates the proapoptotic protein Bim, leading to overexpression of Bcl2, which likely plays a key role in lymphomagenesis. 2276 miR-19a hsa-miR-19a-5p,hsa-miR-19a-3p miRNA BCL2L11 apoptosis down Homo sapiens B-cell 18941111 9606 10018 BAM|BIM|BOD HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 2 2q13 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) Recent studies have shown that miR-17-92 down-regulates the proapoptotic protein Bim, leading to overexpression of Bcl2, which likely plays a key role in lymphomagenesis. 2277 miR-19a hsa-miR-19a-5p,hsa-miR-19a-3p MIMAT0004490,MIMAT0000073 miRNA BCL2L11 apoptosis Homo sapiens lymphoma 22116552 9606 10018 BAM|BIM|BOD HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 2 2q13 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) We demonstrated that the protein phosphatase PHLPP2, an important negative regulator of the PI3K/AKT pathway, was a direct target of miR-17¡«92 miRNAs, in addition to PTEN and BIM.Overexpression of miR-17¡«92 activated the PI3K/AKT pathway and inhibited chemotherapy-induced apoptosis in MCL cell lines. 2278 miR-19a hsa-miR-19a-5p,hsa-miR-19a-3p MIMAT0004490,MIMAT0000073 miRNA PHLPP2 apoptosis Homo sapiens lymphoma 22116552 9606 23035 PHLPPL HGNC:29149|MIM:611066|Ensembl:ENSG00000040199|HPRD:11118|Vega:OTTHUMG00000176867 16 16q22.2 PH domain and leucine rich repeat protein phosphatase 2 protein-coding PH domain and leucine rich repeat protein phosphatase 2 We demonstrated that the protein phosphatase PHLPP2, an important negative regulator of the PI3K/AKT pathway, was a direct target of miR-17¡«92 miRNAs, in addition to PTEN and BIM.Overexpression of miR-17¡«92 activated the PI3K/AKT pathway and inhibited chemotherapy-induced apoptosis in MCL cell lines. 2279 miR-19a hsa-miR-19a-5p,hsa-miR-19a-3p MIMAT0004490,MIMAT0000073 miRNA PTEN apoptosis Homo sapiens lymphoma 22116552 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog We demonstrated that the protein phosphatase PHLPP2, an important negative regulator of the PI3K/AKT pathway, was a direct target of miR-17¡«92 miRNAs, in addition to PTEN and BIM.Overexpression of miR-17¡«92 activated the PI3K/AKT pathway and inhibited chemotherapy-induced apoptosis in MCL cell lines. 2280 miR-19a hsa-miR-19a-3p,hsa-miR-19a-5p MIMAT0000073,MIMAT0004490 miRNA apoptosis Homo sapiens lung cancers 17384677 9606 In the present study, we show that inhibition of miR-17-5p and miR-20a with antisense oligonucleotides (ONs) can induce apoptosis selectively in lung cancer cells overexpressing miR-17-92, suggesting the possibility of 'OncomiR addiction' to expression of these miRNAs in a subset of lung cancers. 2281 miR-19a hsa-miR-19a-5p,hsa-miR-19a-3p MIMAT0000073,MIMAT0004490 miRNA apoptosis Homo sapiens heart, lungs, and immune system. 18423194 9606 MicroRNAs (miRNAs) encoded by the miR-17-92 cluster and its paralogs are known to act as oncogenes. Expression of these miRNAs promotes cell proliferation, suppresses apoptosis of cancer cells, and induces tumor angiogenesis. 2282 miR-19a hsa-miR-19a-3p,hsa-miR-19a-5p MIMAT0000073,MIMAT0004490 miRNA apoptosis Homo sapiens gastrointestinal and other tumors 18922889 9606 The miR-106b-25 and miR-17-92 clusters are emerging as key modulators of TGFbeta signaling in gastrointestinal and other tumors, interfering with cell cycle arrest and apoptosis when overexpressed in cancer cells. 2283 miR-19b-1 hsa-miR-19b-1-5p,hsa-miR-19b-3p MIMAT0004491,MIMAT0000074 miRNA BCL2 apoptosis up Homo sapiens B-cell 18941111 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Recent studies have shown that miR-17-92 down-regulates the proapoptotic protein Bim, leading to overexpression of Bcl2, which likely plays a key role in lymphomagenesis. 2284 miR-19b-1 hsa-miR-19b-1-5p,hsa-miR-19b-3p miRNA BCL2L11 apoptosis down Homo sapiens B-cell 18941111 9606 10018 BAM|BIM|BOD HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 2 2q13 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) Recent studies have shown that miR-17-92 down-regulates the proapoptotic protein Bim, leading to overexpression of Bcl2, which likely plays a key role in lymphomagenesis. 2285 miR-19b-1 hsa-miR-19b-1-5p,hsa-miR-19b-3p MIMAT0004491,MIMAT0000074 miRNA BCL2L11 apoptosis Homo sapiens lymphoma 22116552 9606 10018 BAM|BIM|BOD HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 2 2q13 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) We demonstrated that the protein phosphatase PHLPP2, an important negative regulator of the PI3K/AKT pathway, was a direct target of miR-17¡«92 miRNAs, in addition to PTEN and BIM.Overexpression of miR-17¡«92 activated the PI3K/AKT pathway and inhibited chemotherapy-induced apoptosis in MCL cell lines. 2286 miR-19b-1 hsa-miR-19b-1-5p,hsa-miR-19b-3p MIMAT0004491,MIMAT0000074 miRNA PHLPP2 apoptosis Homo sapiens lymphoma 22116552 9606 23035 PHLPPL HGNC:29149|MIM:611066|Ensembl:ENSG00000040199|HPRD:11118|Vega:OTTHUMG00000176867 16 16q22.2 PH domain and leucine rich repeat protein phosphatase 2 protein-coding PH domain and leucine rich repeat protein phosphatase 2 We demonstrated that the protein phosphatase PHLPP2, an important negative regulator of the PI3K/AKT pathway, was a direct target of miR-17¡«92 miRNAs, in addition to PTEN and BIM.Overexpression of miR-17¡«92 activated the PI3K/AKT pathway and inhibited chemotherapy-induced apoptosis in MCL cell lines. 2287 miR-19b-1 hsa-miR-19b-1-5p,hsa-miR-19b-3p MIMAT0004491,MIMAT0000074 miRNA PTEN apoptosis Homo sapiens lymphoma 22116552 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog We demonstrated that the protein phosphatase PHLPP2, an important negative regulator of the PI3K/AKT pathway, was a direct target of miR-17¡«92 miRNAs, in addition to PTEN and BIM.Overexpression of miR-17¡«92 activated the PI3K/AKT pathway and inhibited chemotherapy-induced apoptosis in MCL cell lines. 2288 miR-19b-1 hsa-miR-19b-1-5p,hsa-miR-19b-3p MIMAT0004491,MIMAT0000074 miRNA apoptosis Homo sapiens lung cancers 17384677 9606 In the present study, we show that inhibition of miR-17-5p and miR-20a with antisense oligonucleotides (ONs) can induce apoptosis selectively in lung cancer cells overexpressing miR-17-92, suggesting the possibility of 'OncomiR addiction' to expression of these miRNAs in a subset of lung cancers. 2289 miR-19b-1 hsa-miR-19b-1-5p,hsa-miR-19b-3p MIMAT0004491,MIMAT0000074 miRNA apoptosis Homo sapiens heart, lungs, and immune system. 18423194 9606 MicroRNAs (miRNAs) encoded by the miR-17-92 cluster and its paralogs are known to act as oncogenes. Expression of these miRNAs promotes cell proliferation, suppresses apoptosis of cancer cells, and induces tumor angiogenesis. 2290 miR-19b-1 hsa-miR-19b-1-5p,hsa-miR-19b-3p MIMAT0004491,MIMAT0000074 miRNA apoptosis Homo sapiens gastrointestinal and other tumors 18922889 9606 The miR-106b-25 and miR-17-92 clusters are emerging as key modulators of TGFbeta signaling in gastrointestinal and other tumors, interfering with cell cycle arrest and apoptosis when overexpressed in cancer cells. 2291 miR-200b hsa-miR-200b-3p,hsa-miR-200b-5p MIMAT0000318,MIMAT0004571 miRNA RHOA apoptosis up Homo sapiens vascular 25279428 9606 387 ARH12|ARHA|RHO12|RHOH12 HGNC:667|MIM:165390|Ensembl:ENSG00000067560|HPRD:01323|Vega:OTTHUMG00000156838 3 3p21.3 ras homolog family member A protein-coding ras homolog family member A AGEs induced ROS production and apoptosis of HUVECs (p < 0.05). AGE-induced miR-200b and miR-200c downregulation led to increased expression of their target genes, RhoA and ROCK, respectively. 2292 miR-200b hsa-miR-200b-3p,hsa-miR-200b-5p MIMAT0000318,MIMAT0004571 miRNA TFAP2A apoptosis down Homo sapiens endometrial cancer 22194984 9606 7020 AP-2|AP-2alpha|AP2TF|BOFS|TFAP2 HGNC:11742|MIM:107580|Ensembl:ENSG00000137203|HPRD:00128|Vega:OTTHUMG00000014235 6 6p24 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) protein-coding transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) The transcription factor AP-2¦Á functions as a tumor suppressor by regulating various genes that are involved in cell proliferation and apoptosis. Luciferase assays and Western blot analysis demonstrated that the miR-200b/200c/429 family recognized the MRE in the 3' UTR of AP-2¦Á gene and negatively regulated the expression of endogenous AP-2¦Á proteins. 2293 miR-200c hsa-miR-200c-3p,hsa-miR-200c-5p MIMAT0000617,MIMAT0004657 miRNA BRD7 apoptosis down Homo sapiens endometrial 22015043 9606 29117 BP75|CELTIX1|NAG4 HGNC:14310|Ensembl:ENSG00000166164|Vega:OTTHUMG00000133170 16 16q12 bromodomain containing 7 protein-coding bromodomain containing 7 Anti-miR or pre-miR-200c could regulate cell survival, proliferation, and apoptosis and affect cytotoxicity in endometrial cancer cells. Through mRNA microarray analysis, we found that miR-200c inhibits the expression of BRD7, which was recently reported as a potential tumor suppressor gene. 2294 miR-200c hsa-miR-200c-3p,hsa-miR-200c-5p MIMAT0000617,MIMAT0004657 miRNA HMOX1 apoptosis down Homo sapiens clear cell renal cell 25150313 9606 3162 HMOX1D|HO-1|HSP32|bK286B10 HGNC:5013|MIM:141250|Ensembl:ENSG00000100292|HPRD:00782|Vega:OTTHUMG00000150960 22 22q13.1 heme oxygenase (decycling) 1 protein-coding heme oxygenase (decycling) 1 Combined application with chemotherapeutic drugs, miR-200c, a?HO-1 inhibitor, may enhance the efficiency of therapy by promoting both apoptosis and autophagy. 2295 miR-200c hsa-miR-200c-3p,hsa-miR-200c-5p MIMAT0000617,MIMAT0004657 miRNA ROCK1 apoptosis up Homo sapiens vascular 25279428 9606 6093 P160ROCK|ROCK-I HGNC:10251|MIM:601702|HPRD:03414 18 18q11.1 Rho-associated, coiled-coil containing protein kinase 1 protein-coding Rho-associated, coiled-coil containing protein kinase 1 AGEs induced ROS production and apoptosis of HUVECs (p < 0.05). AGE-induced miR-200b and miR-200c downregulation led to increased expression of their target genes, RhoA and ROCK, respectively. 2296 miR-200c hsa-miR-200c-3p,hsa-miR-200c-5p MIMAT0000617,MIMAT0004657 miRNA TFAP2A apoptosis down Homo sapiens endometrial cancer 22194984 9606 7020 AP-2|AP-2alpha|AP2TF|BOFS|TFAP2 HGNC:11742|MIM:107580|Ensembl:ENSG00000137203|HPRD:00128|Vega:OTTHUMG00000014235 6 6p24 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) protein-coding transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) The transcription factor AP-2¦Á functions as a tumor suppressor by regulating various genes that are involved in cell proliferation and apoptosis. Luciferase assays and Western blot analysis demonstrated that the miR-200b/200c/429 family recognized the MRE in the 3' UTR of AP-2¦Á gene and negatively regulated the expression of endogenous AP-2¦Á proteins. 2297 miR-203 hsa-miR-203 MIMAT0000264 miRNA SRC apoptosis down Homo sapiens non-small cell lung cancers 22157681 9606 6714 ASV|SRC1|c-SRC|p60-Src HGNC:11283|MIM:190090|Ensembl:ENSG00000197122|HPRD:01819|Vega:OTTHUMG00000032417 20 20q12-q13 SRC proto-oncogene, non-receptor tyrosine kinase protein-coding SRC proto-oncogene, non-receptor tyrosine kinase Here we report that miR-30b/c and miR-221/222, modulated by both EGF and MET receptors, and miR-103, -203, controlled only by MET, play important roles in gefitinib-induced apoptosis and epithelial-mesenchymal transition (EMT) of NSCLC cells, in vitro and in vivo, by inhibiting the expression of Bim, APAF-1, PKC-¦Å and SRC genes. 2298 miR-205 hsa-miR-205-5p,hsa-miR-205-3p MIMAT0000266,MIMAT0009197 miRNA E2F1 apoptosis down Homo sapiens 21454583 9606 1869 E2F-1|RBAP1|RBBP3|RBP3 HGNC:3113|MIM:189971|Ensembl:ENSG00000101412|HPRD:01806|Vega:OTTHUMG00000032265 20 20q11.2 E2F transcription factor 1 protein-coding E2F transcription factor 1 miR-205 significantly suppressed the luciferase activity of reporter plasmids containing the 3'-UTR sequences complementary to either E2F1 or E2F5. Overexpression of miR-205 in melanoma cells reduced E2F1 and E2F5 protein levels. 2299 miR-205 hsa-miR-205-5p,hsa-miR-205-3p MIMAT0000266,MIMAT0009197 miRNA E2F5 apoptosis down Homo sapiens 21454583 9606 1875 E2F-5 HGNC:3119|MIM:600967|Ensembl:ENSG00000133740|HPRD:02983|Vega:OTTHUMG00000164785 8 8q21.2 E2F transcription factor 5, p130-binding protein-coding E2F transcription factor 5, p130-binding miR-205 significantly suppressed the luciferase activity of reporter plasmids containing the 3'-UTR sequences complementary to either E2F1 or E2F5. Overexpression of miR-205 in melanoma cells reduced E2F1 and E2F5 protein levels. 2300 miR-205 hsa-miR-205-5p,hsa-miR-205-3p MIMAT0000266,MIMAT0009197 miRNA EZH2 apoptosis down Homo sapiens prostate cancer 25341040 9606 2146 ENX-1|ENX1|EZH1|EZH2b|KMT6|KMT6A|WVS|WVS2 HGNC:3527|MIM:601573|Ensembl:ENSG00000106462|HPRD:03342|Vega:OTTHUMG00000158973 7 7q35-q36 enhancer of zeste 2 polycomb repressive complex 2 subunit protein-coding enhancer of zeste 2 polycomb repressive complex 2 subunit Suppression of miR-205 with an miRNA inhibitor caused an increase of EZH2 protein, which in turn inhibited miR-31 expression. 2301 miR-206 hsa-miR-206 MIMAT0000462 miRNA OTX2 apoptosis down Homo sapiens neural tube defects 22508046 9606 5015 CPHD6|MCOPS5 HGNC:8522|MIM:600037|Ensembl:ENSG00000165588|HPRD:07190|Vega:OTTHUMG00000152338 14 14q22.3 orthodenticle homeobox 2 protein-coding orthodenticle homeobox 2 Further investigation revealed that miR-206 can interact with 3'-untranslated region (UTR) of Otx2. MiR-206 mimics down-regulated the endogeneous Otx2 expression, whereas the miR-206 inhibitor obviously up-regulated the expression of Otx2. These findings indicate that overexpression of miR-206 promotes cell apoptosis and low expression of miR-206 inhibits cell apoptosis. 2302 miR-206 hsa-miR-206 MIMAT0000462 miRNA apoptosis Homo sapiens hepatocellular carcinoma 25513086 9606 In addition, transfection of miR-206 mimics in HepG2 cells was able to reduce cell proliferation, invasion, and migration, and promote cell apoptosis. 2303 miR-20a hsa-miR-20a-5p,hsa-miR-20a-3p MIMAT0000075,MIMAT0004493 miRNA BCL2 apoptosis up Homo sapiens B-cell 18941111 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Recent studies have shown that miR-17-92 down-regulates the proapoptotic protein Bim, leading to overexpression of Bcl2, which likely plays a key role in lymphomagenesis. 2304 miR-20a hsa-miR-20a-5p,hsa-miR-20a-3p miRNA BCL2L11 apoptosis down Homo sapiens B-cell 18941111 9606 10018 BAM|BIM|BOD HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 2 2q13 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) Recent studies have shown that miR-17-92 down-regulates the proapoptotic protein Bim, leading to overexpression of Bcl2, which likely plays a key role in lymphomagenesis. 2305 miR-20a hsa-miR-20a-5p,hsa-miR-20a-3p MIMAT0000075,MIMAT0004493 miRNA BCL2L11 apoptosis Homo sapiens lymphoma 22116552 9606 10018 BAM|BIM|BOD HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 2 2q13 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) We demonstrated that the protein phosphatase PHLPP2, an important negative regulator of the PI3K/AKT pathway, was a direct target of miR-17¡«92 miRNAs, in addition to PTEN and BIM.Overexpression of miR-17¡«92 activated the PI3K/AKT pathway and inhibited chemotherapy-induced apoptosis in MCL cell lines. 2306 miR-20a hsa-miR-20a-5p,hsa-miR-20a-3p MIMAT0000075,MIMAT0004493 miRNA E2F1 apoptosis down Homo sapiens leukemia 25130806 9606 1869 E2F-1|RBAP1|RBBP3|RBP3 HGNC:3113|MIM:189971|Ensembl:ENSG00000101412|HPRD:01806|Vega:OTTHUMG00000032265 20 20q11.2 E2F transcription factor 1 protein-coding E2F transcription factor 1 Over-expressed miR-17 and miR-20a promote cell growth and cell cycle progression, and inhibit apoptosis through negatively-regulating P21 and E2F1 after-transcriptionally. 2307 miR-20a hsa-miR-20a-5p,hsa-miR-20a-3p MIMAT0000075,MIMAT0004493 miRNA FAS apoptosis down Homo sapiens lung 22186140 9606 355 ALPS1A|APO-1|APT1|CD95|FAS1|FASTM|TNFRSF6 HGNC:11920|MIM:134637|Ensembl:ENSG00000026103|HPRD:00609|Vega:OTTHUMG00000018701 10 10q24.1 Fas cell surface death receptor protein-coding Fas cell surface death receptor Overexpression of miR-20a consistently resulted in the downregulation of Fas expression in SAOS-2 cells and thus in decreased sensitivity to FasL. Conversely, inhibiting miR-20a in LM7 cells increased Fas expression and their sensitivity to FasL. 2308 miR-20a hsa-miR-20a-5p,hsa-miR-20a-3p MIMAT0000075,MIMAT0004493 miRNA PHLPP2 apoptosis Homo sapiens lymphoma 22116552 9606 23035 PHLPPL HGNC:29149|MIM:611066|Ensembl:ENSG00000040199|HPRD:11118|Vega:OTTHUMG00000176867 16 16q22.2 PH domain and leucine rich repeat protein phosphatase 2 protein-coding PH domain and leucine rich repeat protein phosphatase 2 We demonstrated that the protein phosphatase PHLPP2, an important negative regulator of the PI3K/AKT pathway, was a direct target of miR-17¡«92 miRNAs, in addition to PTEN and BIM.Overexpression of miR-17¡«92 activated the PI3K/AKT pathway and inhibited chemotherapy-induced apoptosis in MCL cell lines. 2309 miR-20a hsa-miR-20a-5p,hsa-miR-20a-3p MIMAT0000075,MIMAT0004493 miRNA PTEN apoptosis Homo sapiens lymphoma 22116552 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog We demonstrated that the protein phosphatase PHLPP2, an important negative regulator of the PI3K/AKT pathway, was a direct target of miR-17¡«92 miRNAs, in addition to PTEN and BIM.Overexpression of miR-17¡«92 activated the PI3K/AKT pathway and inhibited chemotherapy-induced apoptosis in MCL cell lines. 2310 miR-20a hsa-miR-20a-5p,hsa-miR-20a-3p MIMAT0004493,MIMAT0000075 miRNA apoptosis Homo sapiens lung cancers 17384677 9606 In the present study, we show that inhibition of miR-17-5p and miR-20a with antisense oligonucleotides (ONs) can induce apoptosis selectively in lung cancer cells overexpressing miR-17-92, suggesting the possibility of 'OncomiR addiction' to expression of these miRNAs in a subset of lung cancers. 2311 miR-20a hsa-miR-20a-5p,hsa-miR-20a-3p MIMAT0000075,MIMAT0004493 miRNA apoptosis Homo sapiens heart, lungs, and immune system. 18423194 9606 MicroRNAs (miRNAs) encoded by the miR-17-92 cluster and its paralogs are known to act as oncogenes. Expression of these miRNAs promotes cell proliferation, suppresses apoptosis of cancer cells, and induces tumor angiogenesis. 2312 miR-20a hsa-miR-20a-5p,hsa-miR-20a-3p MIMAT0000075,MIMAT0004493 miRNA apoptosis Homo sapiens gastrointestinal and other tumors 18922889 9606 The miR-106b-25 and miR-17-92 clusters are emerging as key modulators of TGFbeta signaling in gastrointestinal and other tumors, interfering with cell cycle arrest and apoptosis when overexpressed in cancer cells. 2313 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA AKT1 apoptosis up Homo sapiens brain 25108037 9606 207 AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA HGNC:391|MIM:164730|Ensembl:ENSG00000142208|HPRD:01261|Vega:OTTHUMG00000170795 14 14q32.32 v-akt murine thymoma viral oncogene homolog 1 protein-coding v-akt murine thymoma viral oncogene homolog 1 In conclusion, miR-21 can exert the function of reducing neuronal apoptosis through activating the PTEN-Akt signaling pathway. 2314 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA BCL2 apoptosis up Homo sapiens pancreatic 21376256 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid, in contrast to those transfected with the mutant one, indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA. 2315 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA BTG2 apoptosis down Homo sapiens B16 cells 21940630 9606 7832 PC3|TIS21 HGNC:1131|MIM:601597|Ensembl:ENSG00000159388|HPRD:03357|Vega:OTTHUMG00000035834 1 1q32 BTG family, member 2 protein-coding BTG family, member 2 Moreover, miR-21 knockdown sensitized B16 cells to IFN-induced apoptosis. In B16 cells miR-21 targeted tumor suppressor (PTEN and PDCD4) and antiproliferative (BTG2) proteins. 2316 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA FASLG apoptosis down Homo sapiens liver 25118289 9606 356 ALPS1B|APT1LG1|APTL|CD178|CD95-L|CD95L|FASL|TNFSF6 HGNC:11936|MIM:134638|Ensembl:ENSG00000117560|HPRD:00610|Vega:OTTHUMG00000034841 1 1q23 Fas ligand (TNF superfamily, member 6) protein-coding Fas ligand (TNF superfamily, member 6) Overexpression of miR-21 decreased ethanol-induced apoptosis in both N-Heps and HSCs. A combination of bioinformatics, PCR array, dual-luciferase reporter assay, and Western blot analysis revealed that Fas ligand (TNF superfamily, member 6) (FASLG) and death receptor 5 (DR5) are the direct targets of miR-21. 2317 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA FASLG apoptosis down Homo sapiens glioblastoma 25394756 9606 356 ALPS1B|APT1LG1|APTL|CD178|CD95-L|CD95L|FASL|TNFSF6 HGNC:11936|MIM:134638|Ensembl:ENSG00000117560|HPRD:00610|Vega:OTTHUMG00000034841 1 1q23 Fas ligand (TNF superfamily, member 6) protein-coding Fas ligand (TNF superfamily, member 6) The proliferation of GSCs cell could be inhibited with high-expression of miR-21 and this effect could be restored by miR-21 knocked down. Mechanism analysis revealed that FASLG was a specific and direct target gene of miR-21. The advanced effects of anti-miR-21 on GSCs apoptosis and proliferation were mediated by expression of silenced FASLG. 2318 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA FBXO11 apoptosis down Homo sapiens 25589783 9606 80204 FBX11|PRMT9|UBR6|VIT1 HGNC:13590|MIM:607871|Ensembl:ENSG00000138081|HPRD:06985|Vega:OTTHUMG00000129130 2 2p16.3 F-box protein 11 protein-coding F-box protein 11 Our results identify FBXO11 as a novel miR-21 target gene,and demonstrate that the oncogenic miRNA miR-21 decreases the expression ofFBXO11, which normally acts as a tumor suppressor, and thereby promotestumorigenesis. 2319 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA IL6 apoptosis down Homo sapiens myeloma cells 17496199 9606 3569 BSF2|HGF|HSF|IFNB2|IL-6 HGNC:6018|MIM:147620|Ensembl:ENSG00000136244|HPRD:00970|Vega:OTTHUMG00000023178 7 7p21 interleukin 6 protein-coding interleukin 6 Ectopically raising miR-21 expression in myeloma cells in the absence of IL-6 significantly reduced their apoptosis levels. 2320 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA PDCD4 apoptosis down Homo sapiens B16 cells 21940630 9606 27250 H731 HGNC:8763|MIM:608610|Ensembl:ENSG00000150593|HPRD:10549|Vega:OTTHUMG00000019048 10 10q24 programmed cell death 4 (neoplastic transformation inhibitor) protein-coding programmed cell death 4 (neoplastic transformation inhibitor) Moreover, miR-21 knockdown sensitized B16 cells to IFN-induced apoptosis. In B16 cells miR-21 targeted tumor suppressor (PTEN and PDCD4) and antiproliferative (BTG2) proteins. 2321 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA PDCD4 apoptosis up Homo sapiens diffuse large B-cell lymphoma 25543482 9606 27250 H731 HGNC:8763|MIM:608610|Ensembl:ENSG00000150593|HPRD:10549|Vega:OTTHUMG00000019048 10 10q24 programmed cell death 4 (neoplastic transformation inhibitor) protein-coding programmed cell death 4 (neoplastic transformation inhibitor) The inhibition of miR-21 could induce suppression of proliferation and invasion, as well as increase apoptosis in DLBCL. Moreover, knockdown of miR-21 increased the expressions of PDCD4 and PTEN at the protein level but not at the mRNA level. 2322 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA PTEN apoptosis down Homo sapiens B16 cells 21940630 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog Moreover, miR-21 knockdown sensitized B16 cells to IFN-induced apoptosis. In B16 cells miR-21 targeted tumor suppressor (PTEN and PDCD4) and antiproliferative (BTG2) proteins. 2323 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA PTEN apoptosis down Homo sapiens brain 25108037 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog In conclusion, miR-21 can exert the function of reducing neuronal apoptosis through activating the PTEN-Akt signaling pathway. 2324 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA PTEN apoptosis up Homo sapiens diffuse large B-cell lymphoma 25543482 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog The inhibition of miR-21 could induce suppression of proliferation and invasion, as well as increase apoptosis in DLBCL. Moreover, knockdown of miR-21 increased the expressions of PDCD4 and PTEN at the protein level but not at the mRNA level. 2325 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA RECK apoptosis Homo sapiens glioma cells 18591254 9606 8434 ST15 HGNC:11345|MIM:605227|Ensembl:ENSG00000122707|HPRD:05567|Vega:OTTHUMG00000019898 9 9p13.3 reversion-inducing-cysteine-rich protein with kazal motifs protein-coding reversion-inducing-cysteine-rich protein with kazal motifs We demonstrate that miR-21 regulates multiple genes associated with glioma cell apoptosis, migration, and invasiveness, including the RECK and TIMP3 genes, which are suppressors of malignancy and inhibitors of matrix metalloproteinases (MMPs). 2326 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA STAT3 apoptosis down Homo sapiens hepatic stellate cells 25118289 9606 6774 APRF|HIES HGNC:11364|MIM:102582|Ensembl:ENSG00000168610|HPRD:00026|Vega:OTTHUMG00000150645 17 17q21.31 signal transducer and activator of transcription 3 (acute-phase response factor) protein-coding signal transducer and activator of transcription 3 (acute-phase response factor) Overexpression of miR-21 decreased ethanol-induced apoptosis in both N-Heps and HSCs. The expression level of miR-21 was significantly increased after Stat3 activation in N-Heps and HSCs, in support of the concept that the 5'-promoter region of miR-21 is regulated by Stat3. Using real time PCR,we confirmed that miR-21 activation is associated with ethanol-linked Stat3 binding of the miR-21 promoter. 2327 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA TIMP3 apoptosis Homo sapiens glioma cells 18591254 9606 7078 HSMRK222|K222|K222TA2|SFD HGNC:11822|MIM:188826|Ensembl:ENSG00000100234|HPRD:01785|Vega:OTTHUMG00000030784 22 22q12.3 TIMP metallopeptidase inhibitor 3 protein-coding TIMP metallopeptidase inhibitor 3 We demonstrate that miR-21 regulates multiple genes associated with glioma cell apoptosis, migration, and invasiveness, including the RECK and TIMP3 genes, which are suppressors of malignancy and inhibitors of matrix metalloproteinases (MMPs). 2328 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA TNFRSF10B apoptosis down Homo sapiens liver 25118289 9606 8795 CD262|DR5|KILLER|KILLER/DR5|TRAIL-R2|TRAILR2|TRICK2|TRICK2A|TRICK2B|TRICKB|ZTNFR9 HGNC:11905|MIM:603612|Ensembl:ENSG00000120889|HPRD:04680|Vega:OTTHUMG00000097826 8 8p22-p21 tumor necrosis factor receptor superfamily, member 10b protein-coding tumor necrosis factor receptor superfamily, member 10b Overexpression of miR-21 decreased ethanol-induced apoptosis in both N-Heps and HSCs. A combination of bioinformatics, PCR array, dual-luciferase reporter assay, and Western blot analysis revealed that Fas ligand (TNF superfamily, member 6) (FASLG) and death receptor 5 (DR5) are the direct targets of miR-21. 2329 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA apoptosis Homo sapiens vascular smooth muscle cells 17478730 9606 Depletion of miR-21 resulted in decreased cell proliferation and increased cell apoptosis in a dose-dependent manner. 2330 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA apoptosis Homo sapiens fetal cerebral cortical neuroepithelium. 17687032 9606 Antisense-mediated suppression of miR-21 expression resulted in apoptosis, suggesting that miR-21 is an antiapoptotic factor. 2331 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA apoptosis Homo sapiens glioma cells 17908999 9606 In gliomas, microRNA-21 (miR-21) levels have been reported to be elevated and their knockdown is associated with increased apoptotic activity. 2332 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA apoptosis Homo sapiens 18232304 9606 In this review, we will discuss the function of miRNAs that regulate cell proliferation and apoptosis. Antiapoptotic miRNAs include the miRNAs of the miR-17 cluster, miR-21, bantam and miR-14, Proapoptotic miRNAs include let-7, miR-15a and miR-16. 2333 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA apoptosis Homo sapiens JHU-012 cells 18798260 9606 In addition, flow cytometry analysis of JHU-012 cells 48 hr after mir-21 inhibitor transfection showed a statistically significant increase in cytochrome c release and increased apoptosis. 2334 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA apoptosis Homo sapiens glioblastoma cells 18829576 9606 Down-regulation of miR-21 in glioblastoma cells leads to derepression of these pathways, causing repression of growth, increased apoptosis, and cell cycle arrest. 2335 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA apoptosis Homo sapiens marrow 21698002 9606 We further revealed that over-expression of miR-21, miR-23a and miR-210 could promote the survival of MSCs exposed to hypoxia/SD. In contrast, down-regulation of miR-21, miR-23a and miR-503 aggravated apoptosis of MSCs. 2336 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA apoptosis Homo sapiens kidney 22347428 9606 Functional studies after inhibiting miRNA-21 in RCC cell lines show cell cycle arrest, induction of apoptosis and reduced invasive and migratory capabilities. 2337 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA apoptosis Homo sapiens ¦Â-cell line 25483877 9606 protein coding As overexpression of miR-21 increased proliferation, but also apoptosis and NO synthesis. 2338 miR-21 hsa-miR-21-5p,hsa-miR-21-3p MIMAT0000076,MIMAT0004494 miRNA apoptosis Homo sapiens glioblastomas 25628933 9606 Transfected cells showed a high apoptotic rate compared to control after Dox treatment by TUNEL assay, suggesting that combined Dox and miR-21 inhibitor therapy can sensitize GBM resistant cells to anthracyclines by enhancing apoptosis. 2339 miR-214 hsa-miR-214-3p,hsa-miR-214-5p MIMAT0000271,MIMAT0004564 miRNA PTEN apoptosis down Homo sapiens chronic lymphocytic leukemia 25361012 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog We previous found the expression level of PTEN was low in the chronic lymphocytic leukemia (CLL) patients.We found that PTEN was a potential target of miR-26a and miR-214, which had been confirmed following dual-luciferase reporter assays, reverse transcription polymerase chain reaction and Western blotting.Inhibition of miR-26a or miR-214 could induce more apoptosis in primary cultured CLL cells. 2340 miR-218 hsa-miR-218-5p,hsa-miR-218-1-3p,hsa-miR-218-2-3p MIMAT0000275,MIMAT0004565,MIMAT0004566 miRNA AKT1 apoptosis down Homo sapiens Homo sapiens 21795477 9606 207 AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA HGNC:391|MIM:164730|Ensembl:ENSG00000142208|HPRD:01261|Vega:OTTHUMG00000170795 14 14q32.32 v-akt murine thymoma viral oncogene homolog 1 protein-coding v-akt murine thymoma viral oncogene homolog 1 Ectopic expression of miR-218 and miR-585 in OSCC cells lacking endogenous expression reduced cell growth in part through caspase-mediated apoptosis. Notably, miR-218 reduced levels of the rapamycin-insensitive component of mTOR, Rictor, in a manner associated with a suppression of Akt S473 phosphorylation. 2341 miR-218 hsa-miR-218-5p,hsa-miR-218-1-3p,hsa-miR-218-2-3p MIMAT0000275,MIMAT0004565,MIMAT0004566 miRNA RICTOR apoptosis down Homo sapiens Homo sapiens 21795477 9606 253260 AVO3|PIA|hAVO3 HGNC:28611|MIM:609022|Ensembl:ENSG00000164327|HPRD:10682|Vega:OTTHUMG00000162037 5 5p13.1 RPTOR independent companion of MTOR, complex 2 protein-coding RPTOR independent companion of MTOR, complex 2 Ectopic expression of miR-218 and miR-585 in OSCC cells lacking endogenous expression reduced cell growth in part through caspase-mediated apoptosis. Notably, miR-218 reduced levels of the rapamycin-insensitive component of mTOR, Rictor, in a manner associated with a suppression of Akt S473 phosphorylation. 2342 miR-221 hsa-miR-221-3p,hsa-miR-221-5p MIMAT0000278,MIMAT0004568 miRNA APAF1 apoptosis down Homo sapiens non-small cell lung cancers 22157681 9606 317 APAF-1|CED4 HGNC:576|MIM:602233|Ensembl:ENSG00000120868|HPRD:03755|Vega:OTTHUMG00000170214 12 12q23 apoptotic peptidase activating factor 1 protein-coding apoptotic peptidase activating factor 1 Here we report that miR-30b/c and miR-221/222, modulated by both EGF and MET receptors, and miR-103, -203, controlled only by MET, play important roles in gefitinib-induced apoptosis and epithelial-mesenchymal transition (EMT) of NSCLC cells, in vitro and in vivo, by inhibiting the expression of Bim, APAF-1, PKC-¦Å and SRC genes. 2343 miR-222 hsa-miR-222-3p,hsa-miR-222-5p MIMAT0000279,MIMAT0004569 miRNA APAF1 apoptosis down Homo sapiens non-small cell lung cancers 22157681 9606 317 APAF-1|CED4 HGNC:576|MIM:602233|Ensembl:ENSG00000120868|HPRD:03755|Vega:OTTHUMG00000170214 12 12q23 apoptotic peptidase activating factor 1 protein-coding apoptotic peptidase activating factor 1 Here we report that miR-30b/c and miR-221/222, modulated by both EGF and MET receptors, and miR-103, -203, controlled only by MET, play important roles in gefitinib-induced apoptosis and epithelial-mesenchymal transition (EMT) of NSCLC cells, in vitro and in vivo, by inhibiting the expression of Bim, APAF-1, PKC-¦Å and SRC genes. 2344 miR-22-3p hsa-miR-22-3p MIMAT0000077 miRNA apoptosis Homo sapiens ovarian 25585503 9606 Furthermore, bioinformatics analysis indicated that the target function of miR-22-3p was involved in apoptosis, endocytosis, and tumorigenesis. 2345 miR-23a hsa-miR-23a-3p,hsa-miR-23a-5p MIMAT0000078,MIMAT0004496 miRNA APAF1 apoptosis down Homo sapiens pancreatic cancer 25701323 9606 317 APAF-1|CED4 HGNC:576|MIM:602233|Ensembl:ENSG00000120868|HPRD:03755|Vega:OTTHUMG00000170214 12 12q23 apoptotic peptidase activating factor 1 protein-coding apoptotic peptidase activating factor 1 Ectopic miR-23a significantly suppressed the APAF1 gene expression in pancreatic cancer cells. Similar to siAPAF1, miR-23a significantly promoted pancreatic cancer cell proliferation and repressed apoptosis. 2346 miR-23a hsa-miR-23a-3p,hsa-miR-23a-5p MIMAT0000078,MIMAT0004496 miRNA FAS apoptosis up Homo sapiens thymic cell 25753120 9606 355 ALPS1A|APO-1|APT1|CD95|FAS1|FASTM|TNFRSF6 HGNC:11920|MIM:134637|Ensembl:ENSG00000026103|HPRD:00609|Vega:OTTHUMG00000018701 10 10q24.1 Fas cell surface death receptor protein-coding Fas cell surface death receptor Transfection studies confirmed that DES-mediated downregulation of miR-18b and miR-23a led to increased FasL and Fas expression. These data demonstrated that prenatal DES exposure can cause alterations in miRs, leading to changes in the gene expression, specifically, miR-mediated increased expression in FasL and Fas causing apoptosis and thymic atrophy. 2347 miR-23a hsa-miR-23a-3p,hsa-miR-23a-5p MIMAT0000078,MIMAT0004496 miRNA FASLG apoptosis up Homo sapiens thymic cell 25753120 9606 356 ALPS1B|APT1LG1|APTL|CD178|CD95-L|CD95L|FASL|TNFSF6 HGNC:11936|MIM:134638|Ensembl:ENSG00000117560|HPRD:00610|Vega:OTTHUMG00000034841 1 1q23 Fas ligand (TNF superfamily, member 6) protein-coding Fas ligand (TNF superfamily, member 6) Transfection studies confirmed that DES-mediated downregulation of miR-18b and miR-23a led to increased FasL and Fas expression. These data demonstrated that prenatal DES exposure can cause alterations in miRs, leading to changes in the gene expression, specifically, miR-mediated increased expression in FasL and Fas causing apoptosis and thymic atrophy. 2348 miR-23a hsa-miR-23a-3p,hsa-miR-23a-5p MIMAT0000078,MIMAT0004496 miRNA PMAIP1 apoptosis down Homo sapiens acute lymphoblastic T-cell 25429623 9606 5366 APR|NOXA HGNC:9108|MIM:604959|Ensembl:ENSG00000141682|HPRD:12002|Vega:OTTHUMG00000132765 18 18q21.32 phorbol-12-myristate-13-acetate-induced protein 1 protein-coding phorbol-12-myristate-13-acetate-induced protein 1 Analysis of transcript levels by RT-qPCR revealed that miR-23a levels decreased in heat-stressed cells and that this was correlated with an increased abundance of NOXA mRNA, which contains a miR-23a binding site in its 3' untranslated region. 2349 miR-23a hsa-miR-23a-3p,hsa-miR-23a-5p MIMAT0000078,MIMAT0004496 miRNA apoptosis down Homo sapiens liver cancer cells 18508316 9606 We also explore that miR-23a approximately 27a approximately 24 can function as an antiapoptotic and proliferation-promoting factor in liver cancer cells. 2350 miR-23a hsa-miR-23a-3p,hsa-miR-23a-5p MIMAT0000078,MIMAT0004496 miRNA apoptosis Homo sapiens marrow 21698002 9606 We further revealed that over-expression of miR-21, miR-23a and miR-210 could promote the survival of MSCs exposed to hypoxia/SD. In contrast, down-regulation of miR-21, miR-23a and miR-503 aggravated apoptosis of MSCs. 2351 miR-24 hsa-miR-24-1-5p,hsa-miR-24-3p,hsa-miR-24-2-5p MIMAT0000079,MIMAT0000080,MIMAT0004497 miRNA apoptosis Homo sapiens 25352422 9606 We and others have identified a small non-coding RNA, microRNA-24 (miR-24), as a pro-survival molecule that inhibits the apoptosis of cardiomyocytes. 2352 miR-25 hsa-miR-25-3p,hsa-miR-25-5p MIMAT0004498,MIMAT0000081 miRNA ATXN3 apoptosis down Homo sapiens SCA3/MJD cells 25451224 9606 4287 AT3|ATX3|JOS|MJD|MJD1|SCA3 HGNC:7106|MIM:607047|Ensembl:ENSG00000066427|HPRD:06131|Vega:OTTHUMG00000162212 14 14q21 ataxin 3 protein-coding ataxin 3 miR-25 also increased cell viability, decreased early apoptosis, and downregulated the accumulation of mutant ataxin-3 protein aggregates in SCA3/MJD cells. 2353 miR-25 hsa-miR-25-5p,hsa-miR-25-3p MIMAT0004498,MIMAT0000081 miRNA apoptosis Homo sapiens gastrointestinal and other tumors 18922889 9606 The miR-106b-25 and miR-17-92 clusters are emerging as key modulators of TGFbeta signaling in gastrointestinal and other tumors, interfering with cell cycle arrest and apoptosis when overexpressed in cancer cells. 2354 miR-26a hsa-miR-26a-5p,hsa-miR-26a-1-3p MIMAT0000082,MIMAT0004499 miRNA HMGA1 apoptosis down Homo sapiens Sw1990 and Panc-1 cells 22245693 9606 3159 HMG-R|HMGA1A|HMGIY HGNC:5010|MIM:600701|Ensembl:ENSG00000137309|HPRD:02829|Vega:OTTHUMG00000014539 6 6p21 high mobility group AT-hook 1 protein-coding high mobility group AT-hook 1 Forced expression of miR-26a significantly inhibited cell proliferation, invasion, migration and increased cell apoptosis, whereas knockdown of miR-26a obtained the opposite effect. Furthermore, we demonstrated that HMGA1, an oncogene, is a direct target of miR-26a. 2355 miR-26a hsa-miR-26a-5p,hsa-miR-26a-1-3p MIMAT0000082,MIMAT0004499 miRNA PTEN apoptosis down Homo sapiens chronic lymphocytic leukemia 25361012 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog We previous found the expression level of PTEN was low in the chronic lymphocytic leukemia (CLL) patients.We found that PTEN was a potential target of miR-26a and miR-214, which had been confirmed following dual-luciferase reporter assays, reverse transcription polymerase chain reaction and Western blotting.Inhibition of miR-26a or miR-214 could induce more apoptosis in primary cultured CLL cells. 2356 miR-26b hsa-miR-26b-5p,hsa-miR-26b-3p MIMAT0000083,MIMAT0004500 miRNA PFKFB3 apoptosis down Homo sapiens osteosarcoma 25672572 9606 5209 IPFK2|PFK2 HGNC:8874|MIM:605319|Ensembl:ENSG00000170525|HPRD:05612|Vega:OTTHUMG00000017621 10 10p15.1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 protein-coding 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Restoration of miR-26b expression inhibited cell proliferation, migration and invasion, arrested cell cycle progression, and induced cell apoptosis accompanied by the downregulation of glycolytic phenotype. Moreover, the binding site for miR-26b was predicted in the 3'UTR of gene 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3), 2357 miR-26b hsa-miR-26b-5p,hsa-miR-26b-3p MIMAT0000083,MIMAT0004500 miRNA SMAD4 apoptosis down Homo sapiens granulosa cell 25395673 9606 4089 DPC4|JIP|MADH4|MYHRS HGNC:6770|MIM:600993|Ensembl:ENSG00000141646|HPRD:02995|Vega:OTTHUMG00000132696 18 18q21.1 SMAD family member 4 protein-coding SMAD family member 4 Overexpression and knockdown of SMAD4 increased the proliferation and apoptosis of cultured porcine GCs, respectively. In addition, the use of miRNA mimics and luciferase reporter assays revealed that miRNA-26b (miR-26b) functions as a proapoptotic factor in porcine follicular GCs by targeting the 3'-untranslated region of the SMAD4 gene. 2358 miR-27a hsa-miR-27a-3p,hsa-miR-27a-5p MIMAT0000084,MIMAT0004501 miRNA PLK2 apoptosis down Homo sapiens Hep2 cells 25239093 9606 10769 SNK|hPlk2|hSNK HGNC:19699|MIM:607023|Ensembl:ENSG00000145632|HPRD:06118|Vega:OTTHUMG00000097047 5 5q12.1-q13.2 polo-like kinase 2 protein-coding polo-like kinase 2 In silico database analysis result revealed that PLK2 is a potential target of miR-27a. luciferase reporter assay result showed the direct inhibition of miR-27a on PLK2-3'UTR.Both miR-27a and knockdown of PLK2 caused the increase of the cell viability and colony formation and inhibition of the late apoptosis in the Hep2 cell lines. 2359 miR-27a hsa-miR-27a-3p,hsa-miR-27a-5p MIMAT0000084,MIMAT0004501 miRNA SGPP1 apoptosis down Homo sapiens colorectal cancer 25166914 9606 81537 SPPase1 HGNC:17720|MIM:612826|Ensembl:ENSG00000126821|HPRD:10226|Vega:OTTHUMG00000029080 14 14q23.2 sphingosine-1-phosphate phosphatase 1 protein-coding sphingosine-1-phosphate phosphatase 1 SGPP1 and Smad2 at mRNA and protein levels were negatively correlated with miR-27a in human colorectal cancer tissues and cancer cell lines. Increased miR-27a significantly repressed SGPP1 and Smad2 at transcriptional and translational levels. Functional studies showed that increasing miR-27a inhibited colon cancer cell proliferation, promoted apoptosis and attenuated cell migration, which were also linked to downregulation of p-STAT3 and upregulation of cleaved caspase 3. 2360 miR-27a hsa-miR-27a-3p,hsa-miR-27a-5p MIMAT0000084,MIMAT0004501 miRNA SMAD2 apoptosis down Homo sapiens colorectal cancer 25166914 9606 4087 JV18|JV18-1|MADH2|MADR2|hMAD-2|hSMAD2 HGNC:6768|MIM:601366|Ensembl:ENSG00000175387|HPRD:03221|Vega:OTTHUMG00000132652 18 18q21.1 SMAD family member 2 protein-coding SMAD family member 2 SGPP1 and Smad2 at mRNA and protein levels were negatively correlated with miR-27a in human colorectal cancer tissues and cancer cell lines. Increased miR-27a significantly repressed SGPP1 and Smad2 at transcriptional and translational levels. Functional studies showed that increasing miR-27a inhibited colon cancer cell proliferation, promoted apoptosis and attenuated cell migration, which were also linked to downregulation of p-STAT3 and upregulation of cleaved caspase 3. 2361 miR-27a hsa-miR-27a-3p,hsa-miR-27a-5p MIMAT0000084,MIMAT0004501 miRNA apoptosis Homo sapiens CRL-1690 cell 25628931 9606 Furthermore, the miR-27a oligonucleotide inhibitor induced CRL-1690 cell apoptosis. 2362 miR-29a hsa-miR-29a-3p,hsa-miR-29a-5p MIMAT0000086,MIMAT0004503 miRNA MCL1 apoptosis down Homo sapiens lymphomas 21471522 9606 4170 BCL2L3|EAT|MCL1-ES|MCL1L|MCL1S|Mcl-1|TM|bcl2-L-3|mcl1/EAT HGNC:6943|MIM:159552|Ensembl:ENSG00000143384|HPRD:08870|Vega:OTTHUMG00000034867 1 1q21 myeloid cell leukemia 1 protein-coding myeloid cell leukemia 1 Enforced miR-29a expression was found to modulate apoptosis through inhibition of MCL-1 expression in ALCL cell lines and in a xenografted model, with a concomitant tumor growth reduction. 2363 miR-29b hsa-miR-29b-3p,hsa-miR-29b-1-5p,hsa-miR-29b-2-5p MIMAT0000100,MIMAT0004514,MIMAT0004515 miRNA CASP3 apoptosis up Homo sapiens myeloma 21951844 9606 836 CPP32|CPP32B|SCA-1 HGNC:1504|MIM:600636|Ensembl:ENSG00000164305|HPRD:02799|Vega:OTTHUMG00000133681 4 4q34 caspase 3, apoptosis-related cysteine peptidase protein-coding caspase 3, apoptosis-related cysteine peptidase Using a bioinformatics approach, we found a perfect complementarity between miRNA-29b and the 3'UTR of myeloid-cell-leukemia 1(Mcl-1). It is further confirmed that miRNA-29b downregulated the level of Mcl-1 without effect on the mRNA level using both qRT-PCR assays and Western blot analyses. Moreover, we observed that enforced miR-29b expression by using a retarget miRNA-29b expression vector (Ad5F11p-miR-29b) could induce apoptosis and elevate caspase-3 activation in HMCLs. 2364 miR-29b hsa-miR-29b-3p,hsa-miR-29b-1-5p,hsa-miR-29b-2-5p MIMAT0000100,MIMAT0004514,MIMAT0004515 miRNA IGF1 apoptosis Homo sapiens CRC cell 25592039 9606 3479 IGF-I|IGF1A|IGFI HGNC:5464|MIM:147440|Ensembl:ENSG00000017427|HPRD:00936|Vega:OTTHUMG00000149910 12 12q23.2 insulin-like growth factor 1 (somatomedin C) protein-coding insulin-like growth factor 1 (somatomedin C) Luciferase reporter assays were conducted to determine the association between miR-29b and the insulin-like growth factor 1 (IGF1) 3' untranslated region (3'UTR). IGF1, an activator of PI3K/Akt signaling, was confirmed as a novel target of miR-29b. Moreover, miR-29b increased IRF1 expression, and the inhibition of miR-29b suppressed IFN-¦Ã-induced apoptosis. 2365 miR-29b hsa-miR-29b-3p,hsa-miR-29b-1-5p,hsa-miR-29b-2-5p MIMAT0000100,MIMAT0004514,MIMAT0004515 miRNA IRF1 apoptosis up Homo sapiens CRC cell 25592039 9606 3659 IRF-1|MAR HGNC:6116|MIM:147575|Ensembl:ENSG00000125347|HPRD:00961|Vega:OTTHUMG00000059497 5 5q31.1 interferon regulatory factor 1 protein-coding interferon regulatory factor 1 Luciferase reporter assays were conducted to determine the association between miR-29b and the insulin-like growth factor 1 (IGF1) 3' untranslated region (3'UTR). IGF1, an activator of PI3K/Akt signaling, was confirmed as a novel target of miR-29b. Moreover, miR-29b increased IRF1 expression, and the inhibition of miR-29b suppressed IFN-¦Ã-induced apoptosis. 2366 miR-29b hsa-miR-29b-3p,hsa-miR-29b-1-5p,hsa-miR-29b-2-5p MIMAT0000100,MIMAT0004514,MIMAT0004515 miRNA MCL1 apoptosis down Homo sapiens myeloma 21951844 9606 4170 BCL2L3|EAT|MCL1-ES|MCL1L|MCL1S|Mcl-1|TM|bcl2-L-3|mcl1/EAT HGNC:6943|MIM:159552|Ensembl:ENSG00000143384|HPRD:08870|Vega:OTTHUMG00000034867 1 1q21 myeloid cell leukemia 1 protein-coding myeloid cell leukemia 1 Using a bioinformatics approach, we found a perfect complementarity between miRNA-29b and the 3'UTR of myeloid-cell-leukemia 1(Mcl-1). It is further confirmed that miRNA-29b downregulated the level of Mcl-1 without effect on the mRNA level using both qRT-PCR assays and Western blot analyses. Moreover, we observed that enforced miR-29b expression by using a retarget miRNA-29b expression vector (Ad5F11p-miR-29b) could induce apoptosis and elevate caspase-3 activation in HMCLs. 2367 miR-29b hsa-miR-29b-3p,hsa-miR-29b-1-5p,hsa-miR-29b-2-5p MIMAT0000100,MIMAT0004514,MIMAT0004515 miRNA PTEN apoptosis down Homo sapiens breast cancer 21359530 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog Aberrant expression of miR-29b, which modulates PTEN expression, can contribute to migration, invasion, and anti-apoptosis. 2368 miR-29b hsa-miR-29b-3p,hsa-miR-29b-1-5p,hsa-miR-29b-2-5p MIMAT0000100,MIMAT0004514,MIMAT0004515 miRNA VEGFA apoptosis down Homo sapiens osteosarcoma 25337211 9606 7422 MVCD1|VEGF|VPF HGNC:12680|MIM:192240|Ensembl:ENSG00000112715|HPRD:01889|Vega:OTTHUMG00000014745 6 6p12 vascular endothelial growth factor A protein-coding vascular endothelial growth factor A Overexpression of miR-29b suppressed MG63 cell proliferation, migration and invasion. Meanwhile miR-29b could induce apoptosis of MG63. Besides, miR-29b directly targets VEGF and over-expression of miR-29b led to down-regulation of VEGF protein level. 2369 miR-29c hsa-miR-29c-3p,hsa-miR-29c-5p MIMAT0000681,MIMAT0004673 miRNA apoptosis Homo sapiens dilated cardiomyopathy 25361207 9606 We showed that individual silencing of 7 out of 8 significantly down-regulated miRNAs (mir-1, -29c, -30c, -30d, -149, -486, -499) led to a strong apoptotic phenotype in cell culture, suggesting they repress pro-apoptotic factors. 2370 miR-30a hsa-miR-30a-5p,hsa-miR-30a-3p MIMAT0000087,MIMAT0000088 miRNA UTRN apoptosis down Homo sapiens lung 25284615 9606 7402 DMDL|DRP|DRP1 HGNC:12635|MIM:128240|Ensembl:ENSG00000152818|HPRD:00547|Vega:OTTHUMG00000015746 6 6q24 utrophin protein-coding utrophin This study demonstrated that miR-30a inhibited AECs-II apoptosis by repressing the mitochondrial fission dependent on Drp-1. 2371 miR-30a-5p hsa-miR-30a-5p MIMAT0000087 miRNA apoptosis Homo sapiens human hepatoma cells 25654285 9606 Overexpression of miR-30a-5p had an inhibitory effect on cell proliferation, induced apoptosis, increased the number of cells in S phase, and markedly inhibited invasion and migration of SMCC-7721 HCC cells in vitro and in vivo. 2372 miR-30b hsa-miR-30b-5p,hsa-miR-30b-3p MIMAT0000420,MIMAT0004589 miRNA BCL2L11 apoptosis down Homo sapiens non-small cell lung cancers 22157681 9606 10018 BAM|BIM|BOD HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 2 2q13 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) Here we report that miR-30b/c and miR-221/222, modulated by both EGF and MET receptors, and miR-103, -203, controlled only by MET, play important roles in gefitinib-induced apoptosis and epithelial-mesenchymal transition (EMT) of NSCLC cells, in vitro and in vivo, by inhibiting the expression of Bim, APAF-1, PKC-¦Å and SRC genes. 2373 miR-30c hsa-miR-30c-5p,hsa-miR-30c-2-3p,hsa-miR-30c-1-3p MIMAT0000244,MIMAT0004550,MIMAT0004674 miRNA BCL2L11 apoptosis down Homo sapiens non-small cell lung cancers 22157681 9606 10018 BAM|BIM|BOD HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 2 2q13 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) Here we report that miR-30b/c and miR-221/222, modulated by both EGF and MET receptors, and miR-103, -203, controlled only by MET, play important roles in gefitinib-induced apoptosis and epithelial-mesenchymal transition (EMT) of NSCLC cells, in vitro and in vivo, by inhibiting the expression of Bim, APAF-1, PKC-¦Å and SRC genes. 2374 miR-30c hsa-miR-30c-5p,hsa-miR-30c-2-3p,hsa-miR-30c-1-3p MIMAT0000244,MIMAT0004550,MIMAT0004674 miRNA apoptosis Homo sapiens dilated cardiomyopathy 25361207 9606 We showed that individual silencing of 7 out of 8 significantly down-regulated miRNAs (mir-1, -29c, -30c, -30d, -149, -486, -499) led to a strong apoptotic phenotype in cell culture, suggesting they repress pro-apoptotic factors. 2375 miR-30d hsa-miR-30d-5p,hsa-miR-30d-3p MIMAT0000245,MIMAT0004551 miRNA CASP3 apoptosis down Homo sapiens human solid tumors 22058146 9606 836 CPP32|CPP32B|SCA-1 HGNC:1504|MIM:600636|Ensembl:ENSG00000164305|HPRD:02799|Vega:OTTHUMG00000133681 4 4q34 caspase 3, apoptosis-related cysteine peptidase protein-coding caspase 3, apoptosis-related cysteine peptidase Mir-30d regulates tumor cell proliferation, apoptosis, senescence, and migration. Mechanistic investigations suggested that mir-30d regulates a large number of cancer-associated genes, including the apoptotic caspase CASP3. 2376 miR-30d hsa-miR-30d-5p,hsa-miR-30d-3p MIMAT0000245,MIMAT0004551 miRNA apoptosis Homo sapiens dilated cardiomyopathy 25361207 9606 We showed that individual silencing of 7 out of 8 significantly down-regulated miRNAs (mir-1, -29c, -30c, -30d, -149, -486, -499) led to a strong apoptotic phenotype in cell culture, suggesting they repress pro-apoptotic factors. 2377 miR-30e hsa-miR-30e-5p,hsa-miR-30e-3p MIMAT0000692,MIMAT0000693 miRNA ABL1 apoptosis down Homo sapiens Chronic myeloid leukemia 25305453 9606 25 ABL|JTK7|bcr/abl|c-ABL|c-ABL1|p150|v-abl HGNC:76|MIM:189980|Ensembl:ENSG00000097007|HPRD:01809|Vega:OTTHUMG00000020813 9 9q34.1 ABL proto-oncogene 1, non-receptor tyrosine kinase protein-coding ABL proto-oncogene 1, non-receptor tyrosine kinase Here, we demonstrate that miR-30e is expressed at low levels in CML cell lines and patient samples. Bioinformatics analysis reveals a putative target site for miR-30e in the 3'-untranslated region (UTR) of the ABL gene. In agreement,luciferase assay verified that miR-30e directly targets ABL. Enforced expression of miR-30e in K562 cells suppressed proliferation and induced apoptosis of these cells and sensitized them to imatinib treatment. 2378 miR-31 hsa-miR-31-5p,hsa-miR-31-3p MIMAT0000089,MIMAT0004504 miRNA E2F6 apoptosis down Homo sapiens prostate cancer 25341040 9606 1876 E2F-6 HGNC:3120|MIM:602944|Ensembl:ENSG00000169016|HPRD:04251|Vega:OTTHUMG00000090565 2 2p25.1 E2F transcription factor 6 protein-coding E2F transcription factor 6 SiRNA knockdown of EZH2 increased miR-31 expression and decreased the antiapoptotic protein E2F6 (E2F transcription factor 6) (a target of miR-31), resulting in the sensitization of prostate cancer cells to docetaxel-induced apoptosis. 2379 miR-31 hsa-miR-31-5p,hsa-miR-31-3p MIMAT0000089,MIMAT0004504 miRNA EZH2 apoptosis Homo sapiens prostate cancer 25341040 9606 2146 ENX-1|ENX1|EZH1|EZH2b|KMT6|KMT6A|WVS|WVS2 HGNC:3527|MIM:601573|Ensembl:ENSG00000106462|HPRD:03342|Vega:OTTHUMG00000158973 7 7q35-q36 enhancer of zeste 2 polycomb repressive complex 2 subunit protein-coding enhancer of zeste 2 polycomb repressive complex 2 subunit SiRNA knockdown of EZH2 increased miR-31 expression and decreased the antiapoptotic protein E2F6 (E2F transcription factor 6) (a target of miR-31), resulting in the sensitization of prostate cancer cells to docetaxel-induced apoptosis. 2380 miR-31 hsa-miR-31-5p,hsa-miR-31-3p MIMAT0000089,MIMAT0004504 miRNA NFKB1 apoptosis up Homo sapiens adult T cell leukemia 22264793 9606 4790 EBP-1|KBF1|NF-kB1|NF-kappa-B|NF-kappaB|NFKB-p105|NFKB-p50|NFkappaB|p105|p50 HGNC:7794|MIM:164011|Ensembl:ENSG00000109320|HPRD:01238|Vega:OTTHUMG00000161080 4 4q24 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 protein-coding nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 In ATL cells, miR-31 level is epigenetically regulated, and aberrant upregulation of Polycomb proteins contribute to miR-31 downregulation in an epigenetic fashion, leading to activation of NF-¦ÊB and apoptosis resistance. 2381 miR-32 hsa-miR-32-5p,hsa-miR-32-3p MIMAT0000090,MIMAT0004505 miRNA BCL2L11 apoptosis down Homo sapiens acute myeloid leukemia 21816906 9606 10018 BAM|BIM|BOD HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 2 2q13 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) We report that 1,25D markedly induces expression of miR-32 in human myeloid leukemia cells, in which it targets the 3'-untranslated region of the mRNA encoding the proapoptotic factor Bim to reduce its expression. 2382 miR-32-5p hsa-miR-32-5p MIMAT0000090 miRNA BCL2 apoptosis down Homo sapiens colon cancer cells 25612549 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 The qPCR results indicate that fatty acid-mediated downregulation of hsa-miR-32-5p is accompanied by a downregulation of BCL-2 and BCL2L11 mRNA whereas BCL-XL was shown to be simultaneously upregulated. 2383 miR-32-5p hsa-miR-32-5p MIMAT0000090 miRNA BCL2L1 apoptosis up Homo sapiens colon cancer cells 25612549 9606 598 BCL-XL/S|BCL2L|BCLX|BCLXL|BCLXS|Bcl-X|PPP1R52|bcl-xL|bcl-xS HGNC:992|MIM:600039|Ensembl:ENSG00000171552|HPRD:02497|Vega:OTTHUMG00000032192 20 20q11.21 BCL2-like 1 protein-coding BCL2-like 1 The qPCR results indicate that fatty acid-mediated downregulation of hsa-miR-32-5p is accompanied by a downregulation of BCL-2 and BCL2L11 mRNA whereas BCL-XL was shown to be simultaneously upregulated. 2384 miR-32-5p hsa-miR-32-5p MIMAT0000090 miRNA BCL2L11 apoptosis down Homo sapiens colon cancer cells 25612549 9606 10018 BAM|BIM|BOD HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 2 2q13 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) The qPCR results indicate that fatty acid-mediated downregulation of hsa-miR-32-5p is accompanied by a downregulation of BCL-2 and BCL2L11 mRNA whereas BCL-XL was shown to be simultaneously upregulated. 2385 miR-326 hsa-miR-326 MIMAT0000756 miRNA NOB1 apoptosis down Homo sapiens colorectal carcinoma 25760058 9606 28987 ART-4|MST158|NOB1P|PSMD8BP1 HGNC:29540|MIM:613586|Ensembl:ENSG00000141101|HPRD:11395|Vega:OTTHUMG00000137576 16 16q22.3 NIN1/RPN12 binding protein 1 homolog (S. cerevisiae) protein-coding NIN1/RPN12 binding protein 1 homolog (S. cerevisiae) In the present study, we found that miR-326 inhibited cell proliferation, migration and invasion, and induced cell apoptosis and cell cycle arrest of CRC cells by directly targeting NOB1. 2386 miR-335 hsa-miR-335-5p,hsa-miR-335-3p MIMAT0000765,MIMAT0004703 miRNA MIR21 apoptosis down Homo sapiens fetal cerebral cortical neuroepithelium. 17687032 9606 406991 MIRN21|hsa-mir-21|miR-21|miRNA21 HGNC:31586|MIM:611020|Ensembl:ENSG00000199004|miRBase:MI0000077 17 17q23.1 microRNA 21 ncRNA microRNA 21 MiR-335 knockdown promoted cell proliferation and prevented death induced by concurrently suppressing miR-21, indicating that miR-335 is a proapoptotic, antimitogenic factor whose actions are antagonistic to miR-21. 2387 miR-34 hsa-miR-34a-5p,hsa-miR-34a-3p,hsa-miR-34b-5p,hsa-miR-34b-3p,hsa-miR-34c-5p,hsa-miR-34c-3p MIMAT0000255,MIMAT0004557,MIMAT0000685,MIMAT0000686,MIMAT0004676,MIMAT0004677 miRNA BBC3 apoptosis up Homo sapiens human colon cancer cells 18755897 9606 27113 JFY-1|JFY1|PUMA HGNC:17868|MIM:605854|Ensembl:ENSG00000105327|HPRD:16165|Vega:OTTHUMG00000183489 19 19q13.3-q13.4 BCL2 binding component 3 protein-coding BCL2 binding component 3 MiR-34 inhibition of SIRT1 leads to an increase in acetylated p53 and expression of p21 and PUMA, transcriptional targets of p53 that regulate the cell cycle and apoptosis, respectively. 2388 miR-34 hsa-miR-34a-5p,hsa-miR-34a-3p,hsa-miR-34b-5p,hsa-miR-34b-3p,hsa-miR-34c-5p,hsa-miR-34c-3p MIMAT0000255,MIMAT0004557,MIMAT0000685,MIMAT0000686,MIMAT0004676,MIMAT0004677 miRNA CDKN1A apoptosis up Homo sapiens human colon cancer cells 18755897 9606 1026 CAP20|CDKN1|CIP1|MDA-6|P21|SDI1|WAF1|p21CIP1 HGNC:1784|MIM:116899|Ensembl:ENSG00000124762|HPRD:00298|Vega:OTTHUMG00000014603 6 6p21.2 cyclin-dependent kinase inhibitor 1A (p21, Cip1) protein-coding cyclin-dependent kinase inhibitor 1A (p21, Cip1) MiR-34 inhibition of SIRT1 leads to an increase in acetylated p53 and expression of p21 and PUMA, transcriptional targets of p53 that regulate the cell cycle and apoptosis, respectively. 2389 miR-34 hsa-miR-34a-5p,hsa-miR-34a-3p,hsa-miR-34b-5p,hsa-miR-34b-3p,hsa-miR-34c-5p,hsa-miR-34c-3p MIMAT0000255,MIMAT0004557,MIMAT0000685,MIMAT0000686,MIMAT0004676,MIMAT0004677 miRNA SIRT1 apoptosis down Homo sapiens human colon cancer cells 18755897 9606 23411 SIR2L1 HGNC:14929|MIM:604479|Ensembl:ENSG00000096717|HPRD:08381|Vega:OTTHUMG00000018340 10 10q21.3 sirtuin 1 protein-coding sirtuin 1 MiR-34 inhibition of SIRT1 leads to an increase in acetylated p53 and expression of p21 and PUMA, transcriptional targets of p53 that regulate the cell cycle and apoptosis, respectively. 2390 miR-34 hsa-miR-34a-5p,hsa-miR-34a-3p,hsa-miR-34b-5p,hsa-miR-34b-3p,hsa-miR-34c-5p,hsa-miR-34c-3p MIMAT0000255,MIMAT0004557,MIMAT0000685,MIMAT0000686,MIMAT0004676,MIMAT0004677 miRNA TP53 apoptosis Homo sapiens human colon cancer cells 18755897 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 MiR-34 inhibition of SIRT1 leads to an increase in acetylated p53 and expression of p21 and PUMA, transcriptional targets of p53 that regulate the cell cycle and apoptosis, respectively. 2391 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA 14-3-3sigma apoptosis Homo sapiens BV173 leukemia cells 18677110 9606 Interestingly, we establish that miR-34a cooperates with p21 and 14-3-3sigma to override the apoptotic signals generated by p53 activation. 2392 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA BCL2 apoptosis down Homo sapiens breast cancer 21399894 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Modulation of miR-34a expression was correlated with BCL-2 and cyclin D1 protein expression changes and a direct interaction of miR-34a with BCL-2 was shown by luciferase assay. 2393 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA BCL2 apoptosis down Homo sapiens kidney 25107369 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 The exogenous miR-34a regulates tubular apoptosis by modulating the expression of the anti-apoptotic protein Bcl-2. 2394 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA CCND1 apoptosis down Homo sapiens breast cancer 21399894 9606 595 BCL1|D11S287E|PRAD1|U21B31 HGNC:1582|MIM:168461|Ensembl:ENSG00000110092|HPRD:01346|Vega:OTTHUMG00000167877 11 11q13 cyclin D1 protein-coding cyclin D1 Modulation of miR-34a expression was correlated with BCL-2 and cyclin D1 protein expression changes and a direct interaction of miR-34a with BCL-2 was shown by luciferase assay. 2395 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA CD274 apoptosis down Homo sapiens acute myeloid leukemia 25499621 9606 29126 B7-H|B7H1|PD-L1|PDCD1L1|PDCD1LG1|PDL1 HGNC:17635|MIM:605402|Ensembl:ENSG00000120217|HPRD:05655|Vega:OTTHUMG00000019503 9 9p24 CD274 molecule protein-coding CD274 molecule Using luciferase reporter assay and mutagenesis, we identified miR-34a as a putative binder of the PD-L1-3'UTR. Surface expression of PD-L1 induced by chemotherapeutic agents could also be reversed by miR-34a; furthermore, PD-L1 specific T cell apoptosis was reduced as well following miR-34a transfection. 2396 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA CDKN1A apoptosis Homo sapiens BV173 leukemia cells 18677110 9606 1026 CAP20|CDKN1|CIP1|MDA-6|P21|SDI1|WAF1|p21CIP1 HGNC:1784|MIM:116899|Ensembl:ENSG00000124762|HPRD:00298|Vega:OTTHUMG00000014603 6 6p21.2 cyclin-dependent kinase inhibitor 1A (p21, Cip1) protein-coding cyclin-dependent kinase inhibitor 1A (p21, Cip1) Interestingly, we establish that miR-34a cooperates with p21 and 14-3-3sigma to override the apoptotic signals generated by p53 activation. 2397 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA TGFBR2 apoptosis down Homo sapiens non-small cell lung cancer 25501507 9606 7048 AAT3|FAA3|LDS1B|LDS2|LDS2B|MFS2|RIIC|TAAD2|TGFR-2|TGFbeta-RII HGNC:11773|MIM:190182|Ensembl:ENSG00000163513|HPRD:01823|Vega:OTTHUMG00000130569 3 3p22 transforming growth factor, beta receptor II (70/80kDa) protein-coding transforming growth factor, beta receptor II (70/80kDa) Moreover, miR-34a mimic could inhibit the proliferation and triggered apoptosis in H1299 cells. Luciferase assays revealed that miR-34a inhibited TGF¦ÂR2 expression by targeting one binding site in the 3'-UTR of TGF¦ÂR2 mRNA. 2398 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA TP53 apoptosis Homo sapiens cancers 17540598 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 Hence, miR-34a is a direct proapoptotic transcriptional target of p53 that can mediate some of p53's biological effects. Perturbation of miR-34a expression, as occurs in some human cancers, may thus contribute to tumorigenesis by attenuating p53-dependent apoptosis. 2399 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA TP53 apoptosis Homo sapiens cancer?cells 17996645 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 Their studies highlight the microRNAs miR-34a and miR-34b/c as direct, conserved p53 target genes that presumably mediate induction of apoptosis, cell cycle arrest, and senescence by p53. 2400 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA TP53 apoptosis Homo sapiens lymphocytic 18941118 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 Therefore, low expression of miR-34a in CLL is associated with p53 inactivation but also chemotherapy-refractory disease, impaired DNA damage response, and apoptosis resistance irrespective of 17p deletion/TP53 mutation. 2401 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA apoptosis Homo sapiens several types of cancer 18719384 9606 Ectopic miR-34a induces a G(1) cell cycle arrest, senescence and apoptosis. 2402 miR-34a hsa-miR-34a-5p,hsa-miR-34a-3p MIMAT0000255,MIMAT0004557 miRNA apoptosis Homo sapiens ¦Â-cell line 25483877 9606 protein coding Knockdown of miR-34a slightly decreased proliferation, but as apoptosis and NO synthesis were highly reduced. 2403 miR-34b hsa-miR-34b-5p,hsa-miR-34b-3p MIMAT0000685,MIMAT0004676 miRNA MET apoptosis down Homo sapiens uveal melanoma cell 22419847 9606 4233 AUTS9|HGFR|RCCP2|c-Met HGNC:7029|MIM:164860|Ensembl:ENSG00000105976|HPRD:01280|Vega:OTTHUMG00000023299 7 7q31 MET proto-oncogene, receptor tyrosine kinase protein-coding MET proto-oncogene, receptor tyrosine kinase miR-34b/c caused cell cycle G(1) arrest rather than the induction of apoptosis. Met proto-oncogene (c-Met) was identified as a target of miR-34b/c in uveal melanoma cells. 2404 miR-34b hsa-miR-34b-5p,hsa-miR-34b-3p MIMAT0000685,MIMAT0004676 miRNA TP53 apoptosis Homo sapiens cancer?cells 17996645 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 Their studies highlight the microRNAs miR-34a and miR-34b/c as direct, conserved p53 target genes that presumably mediate induction of apoptosis, cell cycle arrest, and senescence by p53. 2405 miR-34c hsa-miR-34b-5p,hsa-miR-34b-3p MIMAT0000685,MIMAT0004676 miRNA MET apoptosis down Homo sapiens uveal melanoma cell 22419847 9606 4233 AUTS9|HGFR|RCCP2|c-Met HGNC:7029|MIM:164860|Ensembl:ENSG00000105976|HPRD:01280|Vega:OTTHUMG00000023299 7 7q31 MET proto-oncogene, receptor tyrosine kinase protein-coding MET proto-oncogene, receptor tyrosine kinase miR-34b/c caused cell cycle G(1) arrest rather than the induction of apoptosis. Met proto-oncogene (c-Met) was identified as a target of miR-34b/c in uveal melanoma cells. 2406 miR-34c hsa-miR-34c-5p,hsa-miR-34c-3p MIMAT0000686,MIMAT0004677 miRNA TP53 apoptosis Homo sapiens cancer?cells 17996645 9606 7157 BCC7|LFS1|P53|TRP53 HGNC:11998|MIM:191170|Ensembl:ENSG00000141510|HPRD:01859|Vega:OTTHUMG00000162125 17 17p13.1 tumor protein p53 protein-coding tumor protein p53 Their studies highlight the microRNAs miR-34a and miR-34b/c as direct, conserved p53 target genes that presumably mediate induction of apoptosis, cell cycle arrest, and senescence by p53. 2407 miR-34c-3p hsa-miR-34c-3p MIMAT0004677 miRNA apoptosis Homo sapiens SiHa cells 21600876 9606 However, ectopic expression of pre-miR-34c-3p, but not pre-miR-34c-5p, caused S-phase arrest in SiHa cells triggering a strong dose-dependent apoptosis. 2408 miR-378 hsa-miR-378a-5p,hsa-miR-378a-3p,hsa-miR-378b,hsa-miR-378c,hsa-miR-378d,hsa-miR-378e,hsa-miR-378f,hsa-miR-378g,hsa-miR-378h,hsa-miR-378i,hsa-miR-378j MIMAT0000731,MIMAT0000732,MIMAT0014999,MIMAT0016847,MIMAT0018926,MIMAT0018927,MIMAT0018932,MIMAT0018937,MIMAT0018984,MIMAT0019074,MIMAT0024612 miRNA IFNGR1 apoptosis down Homo sapiens corpus luteum 21655975 9606 3459 CD119|IFNGR HGNC:5439|MIM:107470|Ensembl:ENSG00000027697|HPRD:00127|Vega:OTTHUMG00000015656 6 6q23.3 interferon gamma receptor 1 protein-coding interferon gamma receptor 1 The results of real-time RT-PCR of mir-378 and western blot analysis of the IFNGR1 protein at different stages of CL development showed that mir-378 decreased the expression of IFNGR1 protein but not IFNGR1 mRNA. 2409 miR-429 hsa-miR-429 MIMAT0001536 miRNA TFAP2A apoptosis down Homo sapiens endometrial cancer 22194984 9606 7020 AP-2|AP-2alpha|AP2TF|BOFS|TFAP2 HGNC:11742|MIM:107580|Ensembl:ENSG00000137203|HPRD:00128|Vega:OTTHUMG00000014235 6 6p24 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) protein-coding transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) The transcription factor AP-2¦Á functions as a tumor suppressor by regulating various genes that are involved in cell proliferation and apoptosis. Luciferase assays and Western blot analysis demonstrated that the miR-200b/200c/429 family recognized the MRE in the 3' UTR of AP-2¦Á gene and negatively regulated the expression of endogenous AP-2¦Á proteins. 2410 miR-449a hsa-miR-449a MIMAT0001541 miRNA BCL2 apoptosis up Homo sapiens testicular 22008535 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 The gene expression of Bcl-2, target for miR-449a, increased and therefore it is considered anti-apoptotic reaction has started in this stage. 2411 miR-486 hsa-miR-486-5p,hsa-miR-486-3p MIMAT0002177,MIMAT0004762 miRNA apoptosis Homo sapiens dilated cardiomyopathy 25361207 9606 We showed that individual silencing of 7 out of 8 significantly down-regulated miRNAs (mir-1, -29c, -30c, -30d, -149, -486, -499) led to a strong apoptotic phenotype in cell culture, suggesting they repress pro-apoptotic factors. 2412 miR-486-5p hsa-miR-486-5p MIMAT0002177 miRNA AKT1 apoptosis Homo sapiens Homo sapiens 25515961 9606 207 AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA HGNC:391|MIM:164730|Ensembl:ENSG00000142208|HPRD:01261|Vega:OTTHUMG00000170795 14 14q32.32 v-akt murine thymoma viral oncogene homolog 1 protein-coding v-akt murine thymoma viral oncogene homolog 1 Inhibition of miR-486-5p reduced CML progenitor growth and enhanced apoptosis following imatinib treatment.The effects of miR-486-5p on hematopoietic cell growth and survival are mediated at least in part via regulation of AKT signaling and FOXO1 expression. 2413 miR-486-5p hsa-miR-486-5p MIMAT0002177 miRNA FOXO1 apoptosis Homo sapiens Homo sapiens 25515961 9606 2308 FKH1|FKHR|FOXO1A HGNC:3819|MIM:136533|Ensembl:ENSG00000150907|HPRD:00645|Vega:OTTHUMG00000016775 13 13q14.1 forkhead box O1 protein-coding forkhead box O1 Inhibition of miR-486-5p reduced CML progenitor growth and enhanced apoptosis following imatinib treatment.The effects of miR-486-5p on hematopoietic cell growth and survival are mediated at least in part via regulation of AKT signaling and FOXO1 expression. 2414 miR-494 hsa-miR-494-3p,hsa-miR-494-5p MIMAT0002816,MIMAT0026607 miRNA AKT1 apoptosis down Homo sapiens gastrointestinal stromal tumors 22042971 9606 207 AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA HGNC:391|MIM:164730|Ensembl:ENSG00000142208|HPRD:01261|Vega:OTTHUMG00000170795 14 14q32.32 v-akt murine thymoma viral oncogene homolog 1 protein-coding v-akt murine thymoma viral oncogene homolog 1 Induced miR-494 overexpression in GIST882 reduced the expression of downstream molecules in KIT signaling transduction pathways, including phospho-AKT and phospho-STAT3. Finally, miR-494 overexpression provoked apoptosis and inhibited GIST cell growth, which were accompanied by changes in G(1) and S phase content. 2415 miR-494 hsa-miR-494-3p,hsa-miR-494-5p MIMAT0002816,MIMAT0026607 miRNA STAT3 apoptosis down Homo sapiens gastrointestinal stromal tumors 22042971 9606 6774 APRF|HIES HGNC:11364|MIM:102582|Ensembl:ENSG00000168610|HPRD:00026|Vega:OTTHUMG00000150645 17 17q21.31 signal transducer and activator of transcription 3 (acute-phase response factor) protein-coding signal transducer and activator of transcription 3 (acute-phase response factor) Induced miR-494 overexpression in GIST882 reduced the expression of downstream molecules in KIT signaling transduction pathways, including phospho-AKT and phospho-STAT3. Finally, miR-494 overexpression provoked apoptosis and inhibited GIST cell growth, which were accompanied by changes in G(1) and S phase content. 2416 miR-499 hsa-miR-499a-5p£¬hsa-miR-499a-3p MIMAT0002870,MIMAT0004772 miRNA apoptosis Homo sapiens dilated cardiomyopathy 25361207 9606 We showed that individual silencing of 7 out of 8 significantly down-regulated miRNAs (mir-1, -29c, -30c, -30d, -149, -486, -499) led to a strong apoptotic phenotype in cell culture, suggesting they repress pro-apoptotic factors. 2417 miR-503 hsa-miR-503-5p,hsa-miR-503-3p MIMAT0022925,MIMAT0002874 miRNA apoptosis Homo sapiens marrow 21698002 9606 We further revealed that over-expression of miR-21, miR-23a and miR-210 could promote the survival of MSCs exposed to hypoxia/SD. In contrast, down-regulation of miR-21, miR-23a and miR-503 aggravated apoptosis of MSCs. 2418 miR-548-3p hsa-miR-548a-3p,hsa-miR-548b-3p,hsa-miR-548c-3p,hsa-miR-548d-3p,hsa-miR-548g-3p,hsa-miR-548o-3p,hsa-miR-548x-3p,hsa-miR-548ad-3p,hsa-miR-548ae-3p,hsa-miR-548ah-5p,hsa-miR-548aj-3p,hsa-miR-548am-3p,hsa-miR-548e-3p MIMAT0003251,MIMAT0003254,MIMAT0003285,MIMAT0003323,MIMAT0005912,MIMAT0005919,MIMAT0015081,MIMAT0018946,MIMAT0018954,MIMAT0018972,MIMAT0018990,MIMAT0019076,MIMAT0005874 miRNA apoptosis Homo sapiens fibroblasts 18729083 9606 MicroRNAs miR-579, 608, 548-3p, and 585 are noted for targeting genes involved in radioresponsive mechanisms, such as cell cycle checkpoint and apoptosis. 2419 miR-579 hsa-miR-579-5p,hsa-miR-579-3p MIMAT0026616,MIMAT0003244 miRNA apoptosis Homo sapiens fibroblasts 18729083 9606 MicroRNAs miR-579, 608, 548-3p, and 585 are noted for targeting genes involved in radioresponsive mechanisms, such as cell cycle checkpoint and apoptosis. 2420 miR-585 hsa-miR-585-5p,hsa-miR-585-3p MIMAT0026618,MIMAT0003250 miRNA apoptosis Homo sapiens fibroblasts 18729083 9606 MicroRNAs miR-579, 608, 548-3p, and 585 are noted for targeting genes involved in radioresponsive mechanisms, such as cell cycle checkpoint and apoptosis. 2421 miR-608 hsa-miR-608 MIMAT0003276 miRNA apoptosis Homo sapiens fibroblasts 18729083 9606 MicroRNAs miR-579, 608, 548-3p, and 585 are noted for targeting genes involved in radioresponsive mechanisms, such as cell cycle checkpoint and apoptosis. 2422 miR-637 hsa-miR-637 MIMAT0003307 miRNA LIF apoptosis down Homo sapiens autocrine leukemia 21809363 9606 3976 CDF|DIA|HILDA|MLPLI HGNC:6596|MIM:159540|Ensembl:ENSG00000128342|HPRD:08869|Vega:OTTHUMG00000150910 22 22q12.2 leukemia inhibitory factor protein-coding leukemia inhibitory factor In addition, miR-637 overexpression negatively regulated Stat3 phosphorylation by suppressing autocrine leukemia inhibitory factor (LIF) expression and exogenous LIF-triggered Stat3 activation and rescued cell growth in these cells. 2423 miR-637 hsa-miR-637 MIMAT0003307 miRNA STAT3 apoptosis Homo sapiens autocrine leukemia 21809363 9606 6774 APRF|HIES HGNC:11364|MIM:102582|Ensembl:ENSG00000168610|HPRD:00026|Vega:OTTHUMG00000150645 17 17q21.31 signal transducer and activator of transcription 3 (acute-phase response factor) protein-coding signal transducer and activator of transcription 3 (acute-phase response factor) In addition, miR-637 overexpression negatively regulated Stat3 phosphorylation by suppressing autocrine leukemia inhibitory factor (LIF) expression and exogenous LIF-triggered Stat3 activation and rescued cell growth in these cells. 2424 miR-660 hsa-miR-660-5p,hsa-miR-660-3p MIMAT0003338,MIMAT0026907 miRNA MDM2 apoptosis down Homo sapiens lung cancer cells 25501825 9606 4193 ACTFS|HDMX|hdm2 HGNC:6973|MIM:164785|Ensembl:ENSG00000135679|HPRD:01272|Vega:OTTHUMG00000142827 12 12q14.3-q15 MDM2 proto-oncogene, E3 ubiquitin protein ligase protein-coding MDM2 proto-oncogene, E3 ubiquitin protein ligase Transient and stable overexpression of mir-660 using miRNA mimics reduced migration, invasion, and proliferation properties and increased apoptosis in p53 wild-type lung cancer cells.We identified and validated mouse double minute 2 (MDM2) gene, a key regulator of the expression and function of p53, as a new direct target of mir-660. 2425 miR-7-5p hsa-miR-7-5p MIMAT0000252 miRNA PSME3 apoptosis down Homo sapiens Homo sapiens 25511742 9606 10197 HEL-S-283|Ki|PA28-gamma|PA28G|PA28gamma|REG-GAMMA HGNC:9570|MIM:605129|Ensembl:ENSG00000131467|HPRD:05500|Vega:OTTHUMG00000180654 17 17q21 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) protein-coding proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) Furthermore, REG¦Ãwas identified as a direct downstream target of miR-7-5p, and there was aninverse correlation between the expression of REG¦Ã and miR-7-5p. Theoverexpression of miR-7-5p inhibited cell proliferation and induced apoptosis by mainly targeting REG¦Ã in vitro and in vivo. 2426 miR-9 hsa-miR-9-5p,hsa-miR-9-3p MIMAT0000441,MIMAT0000442 miRNA NTRK3 apoptosis Homo sapiens medulloblastoma 18973228 9606 4916 TRKC|gp145(trkC) HGNC:8033|MIM:191316|Ensembl:ENSG00000140538|HPRD:01870|Vega:OTTHUMG00000148677 15 15q25 neurotrophic tyrosine kinase, receptor, type 3 protein-coding neurotrophic tyrosine kinase, receptor, type 3 This property has been addressed for miR-9 and miR-125a, whose rescued expression promoted medulloblastoma cell growth arrest and apoptosis while targeting the proproliferative truncated TrkC isoform. 2427 miR-92-1 hsa-miR-92a-1-5p,hsa-miR-92a-1-3p MIMAT0004507,MIMAT0000092 miRNA BCL2 apoptosis up Homo sapiens B-cell 18941111 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Recent studies have shown that miR-17-92 down-regulates the proapoptotic protein Bim, leading to overexpression of Bcl2, which likely plays a key role in lymphomagenesis. 2428 miR-92-1 hsa-miR-92a-1-5p,hsa-miR-92a-1-3p miRNA BCL2L11 apoptosis down Homo sapiens B-cell 18941111 9606 10018 BAM|BIM|BOD HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 2 2q13 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) Recent studies have shown that miR-17-92 down-regulates the proapoptotic protein Bim, leading to overexpression of Bcl2, which likely plays a key role in lymphomagenesis. 2429 miR-92-1 hsa-miR-92a-1-5p,hsa-miR-92a-1-3p MIMAT0004507,MIMAT0000092 miRNA BCL2L11 apoptosis Homo sapiens lymphoma 22116552 9606 10018 BAM|BIM|BOD HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 2 2q13 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) We demonstrated that the protein phosphatase PHLPP2, an important negative regulator of the PI3K/AKT pathway, was a direct target of miR-17¡«92 miRNAs, in addition to PTEN and BIM.Overexpression of miR-17¡«92 activated the PI3K/AKT pathway and inhibited chemotherapy-induced apoptosis in MCL cell lines. 2430 miR-92-1 hsa-miR-92a-1-5p,hsa-miR-92a-1-3p MIMAT0004507,MIMAT0000092 miRNA PHLPP2 apoptosis Homo sapiens lymphoma 22116552 9606 23035 PHLPPL HGNC:29149|MIM:611066|Ensembl:ENSG00000040199|HPRD:11118|Vega:OTTHUMG00000176867 16 16q22.2 PH domain and leucine rich repeat protein phosphatase 2 protein-coding PH domain and leucine rich repeat protein phosphatase 2 We demonstrated that the protein phosphatase PHLPP2, an important negative regulator of the PI3K/AKT pathway, was a direct target of miR-17¡«92 miRNAs, in addition to PTEN and BIM.Overexpression of miR-17¡«92 activated the PI3K/AKT pathway and inhibited chemotherapy-induced apoptosis in MCL cell lines. 2431 miR-92-1 hsa-miR-92a-1-5p,hsa-miR-92a-1-3p MIMAT0004507,MIMAT0000092 miRNA PTEN apoptosis Homo sapiens lymphoma 22116552 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog We demonstrated that the protein phosphatase PHLPP2, an important negative regulator of the PI3K/AKT pathway, was a direct target of miR-17¡«92 miRNAs, in addition to PTEN and BIM.Overexpression of miR-17¡«92 activated the PI3K/AKT pathway and inhibited chemotherapy-induced apoptosis in MCL cell lines. 2432 miR-92-1 hsa-miR-92a-1-5p,hsa-miR-92a-3p MIMAT0004507,MIMAT0000092 miRNA apoptosis Homo sapiens lung cancers 17384677 9606 In the present study, we show that inhibition of miR-17-5p and miR-20a with antisense oligonucleotides (ONs) can induce apoptosis selectively in lung cancer cells overexpressing miR-17-92, suggesting the possibility of 'OncomiR addiction' to expression of these miRNAs in a subset of lung cancers. 2433 miR-92-1 hsa-miR-92a-1-5p,hsa-miR-92a-1-3p MIMAT0004507,MIMAT0000092 miRNA apoptosis Homo sapiens heart, lungs, and immune system. 18423194 9606 MicroRNAs (miRNAs) encoded by the miR-17-92 cluster and its paralogs are known to act as oncogenes. Expression of these miRNAs promotes cell proliferation, suppresses apoptosis of cancer cells, and induces tumor angiogenesis. 2434 miR-92-1 hsa-miR-92a-1-5p,hsa-miR-92a-1-3p MIMAT0004507,MIMAT0000092 miRNA apoptosis Homo sapiens gastrointestinal and other tumors 18922889 9606 The miR-106b-25 and miR-17-92 clusters are emerging as key modulators of TGFbeta signaling in gastrointestinal and other tumors, interfering with cell cycle arrest and apoptosis when overexpressed in cancer cells. 2435 miR-92a hsa-miR-92a-3p,hsa-miR-92a-1-5p,hsa-miR-92a-2-5p MIMAT0000092,MIMAT0004507,MIMAT0004508 miRNA BCL2L11 apoptosis Homo sapiens colorectal carcinoma 21883694 9606 10018 BAM|BIM|BOD HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|Vega:OTTHUMG00000131256 2 2q13 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) In addition, miR-92a directly targeted the anti-apoptotic molecule BCL-2-interacting mediator of cell death (BIM) in colon cancer tissues. 2436 miR-93 hsa-miR-93-5p,hsa-miR-93-3p MIMAT0000093 ,MIMAT0004509 miRNA apoptosis Homo sapiens gastrointestinal and other tumors 18922889 9606 The miR-106b-25 and miR-17-92 clusters are emerging as key modulators of TGFbeta signaling in gastrointestinal and other tumors, interfering with cell cycle arrest and apoptosis when overexpressed in cancer cells. 2437 miR-96 hsa-miR-96-5p,hsa-miR-96-3p MIMAT0000095,MIMAT0004510 miRNA CASP2 apoptosis down Homo sapiens 25419419 9606 835 CASP-2|ICH1|NEDD-2|NEDD2|PPP1R57 HGNC:1503|MIM:600639|Ensembl:ENSG00000106144|HPRD:02800|Vega:OTTHUMG00000023641 7 7q34-q35 caspase 2, apoptosis-related cysteine peptidase protein-coding caspase 2, apoptosis-related cysteine peptidase Luciferase reporter assay confirmed that Casp-2 was directly bound by miR-96 in RGC-5 cells, and siRNA-regulated silencing of CASP2 gene rescued the apoptosis in RGC-5 induced by over-expressing miR-96. 2438 E2 93A1D1FEA2961365482571F8000697C3?OpenDocument snoRNA CEBPA apoptosis up Homo sapiens myeloid precursor cells 11753385 9606 1050 C/EBP-alpha|CEBP HGNC:1833|MIM:116897|Ensembl:ENSG00000245848|HPRD:00296|Vega:OTTHUMG00000161461 19 19q13.1 CCAAT/enhancer binding protein (C/EBP), alpha protein-coding CCAAT/enhancer binding protein (C/EBP), alpha CCAAT/enhancer-binding pr Ectopic expression of hnRNP E2 in myeloid precursor cells down-regulates both C/EBPalpha and G-CSF-Rand leads to rapid cell death on treatment with G-CSF (encoded by CSF3). 2439 hTR 830A6A975E472702482571F80006A5FE?OpenDocument snoRNA apoptosis down Homo sapiens gastric cancer cell 11866938 9606 Antisense htr expression was enhanced and sense htr expression inhibited in clones containing antisense htr after hygromycin resistant selection which induced tumor cells apoptosis. 2440 hTR 830A6A975E472702482571F80006A5FE?OpenDocument snoRNA apoptosis down Homo sapiens breast tumor cells 15551309 9606 Attenuation of telomerase activity by hammerhead ribozyme targeting humantelomerase RNA induces growth retardation and apoptosis in human breast tumorcells. 2441 hTR 830A6A975E472702482571F80006A5FE?OpenDocument snoRNA apoptosis down Homo sapiens renal carcinoma cells 16820866 9606 Sirna targeting at both htr and htert mrna on the inhibition telomerase activity in human renal carcinoma cells (hrccs). The proliferation and apoptosis of hrccs were examined. 2442 hTR 830A6A975E472702482571F80006A5FE?OpenDocument snoRNA apoptosis Homo sapiens cervical cancer cells 17479103 9606 Ad-htr-sirna significantly reduced both htr mrna level (by 70.21%) and telomerase activity (by 58.87%) in HeLa cells. Moreover, it induced apoptosis in hela cells. 2443 hTR 830A6A975E472702482571F80006A5FE?OpenDocument snoRNA apoptosis Homo sapiens 19056167 9606 Telomerase core components are a catalytic subunit TERT and an RNA subunit TR (hTR in humans, mTR in mouse) that carries the template to generate telomeres de novo. Telomere dysfunction can lead to senescence or apoptosis and impairs the continued growth of immortal cancerous cell lines. The introduction of a template-mutated hTR in telomerase-positive and telomerase-negative human cell lines results in dramatic growth defects. 2444 hTR 830A6A975E472702482571F80006A5FE?OpenDocument snoRNA apoptosis down Homo sapiens glioma cells 21472336 9606 Combination of tamoxifen and antisense human telomerase RNA inhibits glioma cell proliferation and anti-apoptosis via suppression of telomerase activity. 2445 hTR snoRNA apoptosis Homo sapiens 25320237 9606 Hence, we propose that hTR can function as a noncoding RNA that protects from apoptosis independent of its function in telomerase enzymatic activity and long-term telomere maintenance in normal human immune cells. 2446 U32A snoRNA apoptosis Homo sapiens cells exposed to too much fat 21723502 9606 Loss of three box C/D small nucleolar RNAs (snoRNAs) encoded in the ribosomal protein L13a (rpL13a) locus is sufficient to confer resistance to lipotoxic and oxidative stress in vitro and prevents the propagation of oxidative stress in vivo. 2447 U33 snoRNA apoptosis Homo sapiens cells exposed to too much fat 21723502 9606 Loss of three box C/D small nucleolar RNAs (snoRNAs) encoded in the ribosomal protein L13a (rpL13a) locus is sufficient to confer resistance to lipotoxic and oxidative stress in?vitro and prevents the propagation of oxidative stress in?vivo. 2448 U35a snoRNA apoptosis Homo sapiens cells exposed to too much fat 21723502 9606 Loss of three box C/D small nucleolar RNAs (snoRNAs) encoded in the ribosomal protein L13a (rpL13a) locus is sufficient to confer resistance to lipotoxic and oxidative stress in?vitro and prevents the propagation of oxidative stress in?vivo. 2449 hTERT snoRNA apoptosis down Homo sapiens renal carcinoma cells 16820866 9606 Sirna targeting at both htr and htert mrna on the inhibition telomerase activity in human renal carcinoma cells (hrccs). The proliferation and apoptosis of hrccs were examined. 2450 miR-29b bta-miR-29b MIMAT0003828 miRNA ATG14 autophagy down Bos taurus kidney 25234643 9913 538831 - BGD:BT20206|Ensembl:ENSBTAG00000010795 10 - ATG14 autophagy related 14 homolog (S. cerevisiae) protein-coding - MiR-29b overexpression mediated by miRNA precursor-expressing lentivirus resulted in the attenuation of BVDV NADL infection-related autophagy by directly downregulating the intracellular expression levels of two key autophagy-associated proteins, ATG14 and ATG9A. 2451 miR-29b bta-miR-29b MIMAT0003828 miRNA ATG9A autophagy down Bos taurus kidney 25234643 9913 540482 ATG9 BGD:BT13106|Ensembl:ENSBTAG00000020608 2 - ATG9 autophagy related 9 homolog A (S. cerevisiae) protein-coding - MiR-29b overexpression mediated by miRNA precursor-expressing lentivirus resulted in the attenuation of BVDV NADL infection-related autophagy by directly downregulating the intracellular expression levels of two key autophagy-associated proteins, ATG14 and ATG9A. 2452 let-7g hsa-let-7g-5p,hsa-let-7g-3p MIMAT0000414,MIMAT0004584 miRNA Olr1 autophagy Mus musculus vascular smooth muscle cells 23305858 10090 108078 LOX-1|SR-EI|Scare1 MGI:1261434|Ensembl:ENSMUSG00000030162|Vega:OTTMUSG00000034583 6 6 F3|6 oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding oxidized low density lipoprotein (lectin-like) receptor 1 Our observations also suggest that hsa-let-7 g acts as a critical regulator of autophagy and apoptosis by modulating LOX-1. 2453 miR-106 mmu-miR-106a-5p,mmu-miR-106a-3p,mmu-miR-106b-5p,mmu-miR-106a-3p MIMAT0000385,MIMAT0017009,MIMAT0000386,MIMAT000458 miRNA Sqstm1 autophagy down Mus musculus myeloid progenitors 21628417 10090 18412 A170|OSF-6|Osi|STAP|STONE14|p62 MGI:107931|Ensembl:ENSMUSG00000015837|Vega:OTTMUSG00000005574 11 11|11 B1.2 sequestosome 1 protein-coding sequestosome 1 STONE14; oxidative stress Here, we show that ectopic expression o miR-17, -20,-93 and -106, all AAAGUGC seed-containing miRNAs, increases proliferation, colony outgrowth and replating capacity of myeloid progenitors an results in enhanced P-ERK levels. Quantitative proteomics identified sequestosome 1 (SQSTM1), an ubiquitin-binding protein and regulator of autophagy mediated protein degradation, as a major target for these miRNAs in myeloid progenitors. 2454 miR-132 mmu-miR-132-3p,mmu-miR-132-5p MIMAT0000144,MIMAT0016984 miRNA Foxo3 autophagy down Mus musculus cardiomyocyte cell line cells 23011132 10090 56484 1110048B16Rik|2010203A17Rik|C76856|FKHRL1|Fkhr2|Foxo3a MGI:1890081|Ensembl:ENSMUSG00000048756|Vega:OTTMUSG00000020929 10 10 B2|10 22.79 cM forkhead box O3 protein-coding forkhead box O3 Both miR-212 and miR-132 directly target the anti-hypertrophic and pro-autophagic FoxO3 transcription factor and overexpression of these miRNAs leads to hyperactivation of pro-hypertrophic calcineurin/NFAT signalling and an impaired autophagic response upon starvation. 2455 miR-146a mmu-miR-146a-5p,mmu-miR-146a-3p MIMAT0000158,MIMAT0016989 miRNA Nfkb1 autophagy up Mus musculus breast cancer cell 23647548 10090 18033 NF-KB1|NF-kappaB|NF-kappaB1|p105|p50|p50/p105 MGI:97312|Ensembl:ENSMUSG00000028163|Vega:OTTMUSG00000016668 3 3 G3|3 62.82 cM nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 protein-coding nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 In the present study, we report that TRAIL suppressed CXCR4-mediated human breast cancer MDA-MB-231 cell migration by up-regulating miR-146a expression through NF-¦ÊB. TRAIL receptor 1 (TRAIL-R1, DR4) was highly expressed in TRAIL-treated MDA-MB-231 cells. 2456 miR-15b mmu-miR-15b-5p,mmu-miR-15b-3p MIMAT0000124,MIMAT0004521 miRNA Bcl2l2 autophagy Mus musculus neuroectodermal tissues 21770019 10090 12050 AW048834|Bcl-w|Gtrgal2|Gtrosa41|bclw|c98 MGI:108052|Ensembl:ENSMUSG00000089682|Vega:OTTMUSG00000032812 14 14 C3|14 27.98 cM BCL2-like 2 protein-coding BCL2-like 2 MicroRNAs miR-16-1 (miR-16) and miR-15b have been reported to function as tumor suppressors and negative regulators of cell growth. A number of studies support the existence of a complex interplay between autophagy, cell growth and apoptosis required for mammalian neural tube development. Bcl2 and the Bcl2-like anti-apoptotic proteins BCL2-associated athanogene 5 (Bag5) and BCL2-like 2 (Blc2l2) are targets of miR-16 and miR-15a (miRDB). 2457 miR-16 mmu-miR-16-5p,mmu-miR-16-1-3p,mmu-miR-16-2-3p MIMAT0000527,MIMAT0004625,MIMAT0017018 miRNA Bag5 autophagy Mus musculus neuroectodermal tissues 21770019 10090 70369 1600025G07Rik|4930405J06Rik MGI:1917619|Ensembl:ENSMUSG00000049792|Vega:OTTMUSG00000028789 12 12 F2|12 BCL2-associated athanogene 5 protein-coding BCL2-associated athanogene 5 MicroRNAs miR-16-1 (miR-16) and miR-15b have been reported to function as tumor suppressors and negative regulators of cell growth. A number of studies support the existence of a complex interplay between autophagy, cell growth and apoptosis required for mammalian neural tube development. Bcl2 and the Bcl2-like anti-apoptotic proteins BCL2-associated athanogene 5 (Bag5) and BCL2-like 2 (Blc2l2) are targets of miR-16 and miR-15a (miRDB). 2458 miR-17 mmu-miR-17-5p,mmu-miR-17-3p MIMAT0000649,MIMAT0000650 miRNA Adcy5 autophagy Mus musculus 25077541 10090 224129 AW121902|Ac5 MGI:99673 16 16|16 B-5 adenylate cyclase 5 protein-coding adenylate cyclase 5 We propose that miR-17 acts as a critical regulator of cellular senescence and tumorigenesis. We demonstrate that miR-17 targets both ADCY5 and IRS1, upregulating the downstream signals MKP7, FoxO3, LC3B, and HIF1¦Á, and downregulating mTOR, c-myc, cyclin D1, and JNK. Silencing either ADCY5 or IRS1 promoted autophagy and repressed cellular senescence and apoptosis. 2459 miR-17 mmu-miR-17-5p,mmu-miR-17-3p MIMAT0000649,MIMAT0000650 miRNA Irs1 autophagy Mus musculus 25077541 10090 16367 G972R|IRS-1 MGI:99454|Ensembl:ENSMUSG00000055980|Vega:OTTMUSG00000016464 1 1 C5|1 42.0 cM insulin receptor substrate 1 protein-coding insulin receptor substrate 1 We propose that miR-17 acts as a critical regulator of cellular senescence and tumorigenesis. We demonstrate that miR-17 targets both ADCY5 and IRS1, upregulating the downstream signals MKP7, FoxO3, LC3B, and HIF1¦Á, and downregulating mTOR, c-myc, cyclin D1, and JNK. Silencing either ADCY5 or IRS1 promoted autophagy and repressed cellular senescence and apoptosis. 2460 miR-17 mmu-miR-17-5p,mmu-miR-17-3p MIMAT0000649,MIMAT0000650 miRNA Sqstm1 autophagy down Mus musculus myeloid progenitors 21628417 10090 18412 A170|OSF-6|Osi|STAP|STONE14|p62 MGI:107931|Ensembl:ENSMUSG00000015837|Vega:OTTMUSG00000005574 11 11|11 B1.2 sequestosome 1 protein-coding sequestosome 1 STONE14; oxidative stress Here, we show that ectopic expression o miR-17, -20,-93 and -106, all AAAGUGC seed-containing miRNAs, increases proliferation, colony outgrowth and replating capacity of myeloid progenitors an results in enhanced P-ERK levels. Quantitative proteomics identified sequestosome 1 (SQSTM1), an ubiquitin-binding protein and regulator of autophagy mediated protein degradation, as a major target for these miRNAs in myeloid progenitors. 2461 miR-1981 mmu-miR-1981-5p,mmu-miR-1981-3p MIMAT0009458,MIMAT0017351 miRNA Bcl2 autophagy Mus musculus 22904669 10090 12043 AW986256|Bcl-2|C430015F12Rik|D630044D05Rik|D830018M01Rik MGI:88138|Ensembl:ENSMUSG00000057329|Vega:OTTMUSG00000022128 1 1 E2.1|1 49.76 cM B cell leukemia/lymphoma 2 protein-coding B cell leukemia/lymphoma 2 Furthermore, the interactions of miR-1981 and its target genes, Bcl-2 and Bid, were validated by luciferase assay. 2462 miR-1981 mmu-miR-1981-5p,mmu-miR-1981-3p MIMAT0009458,MIMAT0017351 miRNA Bid autophagy Mus musculus 22904669 10090 12122 2700049M22Rik|AI875481|AU022477 MGI:108093|Ensembl:ENSMUSG00000004446|Vega:OTTMUSG00000024186 6 6 F1|6 57.02 cM BH3 interacting domain death agonist protein-coding BH3 interacting domain death agonist Furthermore, the interactions of miR-1981 and its target genes, Bcl-2 and Bid, were validated by luciferase assay. 2463 miR-199a-5p mmu-miR-199a-5p MIMAT0000229 miRNA Hspa5 autophagy down Mus musculus liver cells 23598416 10090 14828 AL022860|AU019543|Bip|D2Wsu141e|D2Wsu17e|Grp78|Hsce70|SEZ-7|Sez7|baffled|mBiP MGI:95835|Ensembl:ENSMUSG00000026864|Vega:OTTMUSG00000012014 2 2 B|2 22.94 cM heat shock protein 5 protein-coding heat shock protein 5 MiR-199a-5p is one of the most broadly conserved miRNAs and is generally believed to be a multifunctional miRNA involved in the regulation of angiogenesis,cell proliferation,autophagy,and many other cell functions.We also validated their finding that miR-199a-5p targets GRP78. 2464 miR-20 mmu-miR-20a-5p,mmu-miR-20a-3p MIMAT0000529,MIMAT0004627 miRNA Sqstm1 autophagy down Mus musculus myeloid progenitors 21628417 10090 18412 A170|OSF-6|Osi|STAP|STONE14|p62 MGI:107931|Ensembl:ENSMUSG00000015837|Vega:OTTMUSG00000005574 11 11|11 B1.2 sequestosome 1 protein-coding sequestosome 1 STONE14; oxidative stress Here, we show that ectopic expression o miR-17, -20,-93 and -106, all AAAGUGC seed-containing miRNAs, increases proliferation, colony outgrowth and replating capacity of myeloid progenitors an results in enhanced P-ERK levels. Quantitative proteomics identified sequestosome 1 (SQSTM1), an ubiquitin-binding protein and regulator of autophagy mediated protein degradation, as a major target for these miRNAs in myeloid progenitors. 2465 miR-212 mmu-miR-212-3p,mmu-miR-212-5p MIMAT0000659,MIMAT0017053 miRNA Foxo3 autophagy down Mus musculus cardiomyocyte cell line cells 23011132 10090 56484 1110048B16Rik|2010203A17Rik|C76856|FKHRL1|Fkhr2|Foxo3a MGI:1890081|Ensembl:ENSMUSG00000048756|Vega:OTTMUSG00000020929 10 10 B2|10 22.79 cM forkhead box O3 protein-coding forkhead box O3 Both miR-212 and miR-132 directly target the anti-hypertrophic and pro-autophagic FoxO3 transcription factor and overexpression of these miRNAs leads to hyperactivation of pro-hypertrophic calcineurin/NFAT signalling and an impaired autophagic response upon starvation. 2466 miR-290 mmu-miR-290a-5p,mmu-miR-290a-3p,mmu-miR-290b-5p,mmu-miR-290b-5p MIMAT0000366,MIMAT0004572,MIMAT0029900,MIMAT0029901 miRNA Atg7 autophagy down Mus musculus melanoma cell 23150779 10090 74244 1810013K23Rik|Agp7|Apg7l|Atg7l|Gm21553 MGI:1921494|Ensembl:ENSMUSG00000030314|Vega:OTTMUSG00000043567 6 6 E3|6 autophagy related 7 protein-coding autophagy related 7 Indeed, ATG5 cellular levels were decreased in cells upon MIR181A overexpression and increased following the introduction of antagomirs. More importantly, overexpression of ATG5 from a miRNA-insensitive cDNA construct rescued autophagic activity in the presence of MIR181A. We also showed that the ATG5 3' UTR contained functional MIR181A responsive sequences sensitive to point mutations. Therefore, MIR181A is a novel and important regulator of autophagy and ATG5 is a rate-limiting miRNA target in this effect. 2467 miR-290 mmu-miR-290a-5p,mmu-miR-290a-3p,mmu-miR-290b-5p,mmu-miR-290b-3p MIMAT0000366,MIMAT0004572,MIMAT0029900,MIMAT002990 miRNA Ulk1 autophagy down Mus musculus melanoma cell lines 23150779 10090 22241 AU041434|Unc51.1|mKIAA0722 MGI:1270126|Ensembl:ENSMUSG00000029512 5 5|5 F unc-51 like kinase 1 protein-coding unc-51 like kinase 1 Autophagy mediates cell death of melanoma cells under chronic nutrient deprivation, and they reveal an unanticipated role of the miR-290-295 cluster in conferring a survival advantage to melanoma cells by inhibiting autophagic cell death.This was mediated by miR-290-295-induced downregulation of several essential autophagy genes, including Atg7 and ULK1, which resulted in inhibition of autophagic cell death induced by glucose starvation 2468 miR-291 mmu-miR-291a-5p,mmu-miR-291a-3p,mmu-miR-291b-5p,mmu-miR-291b-3p MIMAT0000367,MIMAT0000368,MIMAT0003189,MIMAT000319 miRNA Atg7 autophagy down Mus musculus melanoma cells 23150779 10090 74244 1810013K23Rik|Agp7|Apg7l|Atg7l|Gm21553 MGI:1921494|Ensembl:ENSMUSG00000030314|Vega:OTTMUSG00000043567 6 6 E3|6 autophagy related 7 protein-coding autophagy related 7 Autophagy mediates cell death of melanoma cells under chronic nutrient deprivation, and they reveal an unanticipated role of the miR-290-295 cluster in conferring a survival advantage to melanoma cells by inhibiting autophagic cell death. 2469 miR-291 mmu-miR-291a-5p,mmu-miR-291a-3p,mmu-miR-291b-5p,mmu-miR-291b-3p MIMAT0000367,MIMAT0000368,MIMAT0003189,MIMAT000319 miRNA Ulk1 autophagy down Mus musculus melanoma cell lines 23150779 10090 22241 AU041434|Unc51.1|mKIAA0722 MGI:1270126|Ensembl:ENSMUSG00000029512 5 5|5 F unc-51 like kinase 1 protein-coding unc-51 like kinase 1 Autophagy mediates cell death of melanoma cells under chronic nutrient deprivation, and they reveal an unanticipated role of the miR-290-295 cluster in conferring a survival advantage to melanoma cells by inhibiting autophagic cell death.This was mediated by miR-290-295-induced downregulation of several essential autophagy genes, including Atg7 and ULK1, which resulted in inhibition of autophagic cell death induced by glucose starvation 2470 miR-292 mmu-miR-292a-5p,mmu-miR-292a-3p,mmu-miR-292b-5p,mmu-miR-29ba-3p MIMAT0000369,MIMAT0000370,MIMAT0029864,MIMAT0029865 miRNA Atg7 autophagy down Mus musculus melanoma cells 23150779 10090 74244 1810013K23Rik|Agp7|Apg7l|Atg7l|Gm21553 MGI:1921494|Ensembl:ENSMUSG00000030314|Vega:OTTMUSG00000043567 6 6 E3|6 autophagy related 7 protein-coding autophagy related 7 Autophagy mediates cell death of melanoma cells under chronic nutrient deprivation, and they reveal an unanticipated role of the miR-290-295 cluster in conferring a survival advantage to melanoma cells by inhibiting autophagic cell death. 2471 miR-292 mmu-miR-292-5p,mmu-miR-292-3p MIMAT0000369,MIMAT0000370 miRNA Ulk1 autophagy down Mus musculus melanoma cell lines 23150779 10090 22241 AU041434|Unc51.1|mKIAA0722 MGI:1270126|Ensembl:ENSMUSG00000029512 5 5|5 F unc-51 like kinase 1 protein-coding unc-51 like kinase 1 Autophagy mediates cell death of melanoma cells under chronic nutrient deprivation, and they reveal an unanticipated role of the miR-290-295 cluster in conferring a survival advantage to melanoma cells by inhibiting autophagic cell death.This was mediated by miR-290-295-induced downregulation of several essential autophagy genes, including Atg7 and ULK1, which resulted in inhibition of autophagic cell death induced by glucose starvation 2472 miR-293 mmu-miR-293-5p,mmu-miR-293-3p MIMAT0004573,MIMAT0000371 miRNA Atg7 autophagy down Mus musculus melanoma cells 23150779 10090 74244 1810013K23Rik|Agp7|Apg7l|Atg7l|Gm21553 MGI:1921494|Ensembl:ENSMUSG00000030314|Vega:OTTMUSG00000043567 6 6 E3|6 autophagy related 7 protein-coding autophagy related 7 Autophagy mediates cell death of melanoma cells under chronic nutrient deprivation, and they reveal an unanticipated role of the miR-290-295 cluster in conferring a survival advantage to melanoma cells by inhibiting autophagic cell death. 2473 miR-293 mmu-miR-293-5p,mmu-miR-293-3p MIMAT0004573,MIMAT0000371 miRNA Ulk1 autophagy down Mus musculus melanoma cell lines 23150779 10090 22241 AU041434|Unc51.1|mKIAA0722 MGI:1270126|Ensembl:ENSMUSG00000029512 5 5|5 F unc-51 like kinase 1 protein-coding unc-51 like kinase 1 Autophagy mediates cell death of melanoma cells under chronic nutrient deprivation, and they reveal an unanticipated role of the miR-290-295 cluster in conferring a survival advantage to melanoma cells by inhibiting autophagic cell death.This was mediated by miR-290-295-induced downregulation of several essential autophagy genes, including Atg7 and ULK1, which resulted in inhibition of autophagic cell death induced by glucose starvation 2474 miR-294 mmu-miR-294-5p,mmu-miR-294-3p MIMAT0004574,MIMAT0000372 miRNA Atg7 autophagy down Mus musculus melanoma cells 23150779 10090 74244 1810013K23Rik|Agp7|Apg7l|Atg7l|Gm21553 MGI:1921494|Ensembl:ENSMUSG00000030314|Vega:OTTMUSG00000043567 6 6 E3|6 autophagy related 7 protein-coding autophagy related 7 Autophagy mediates cell death of melanoma cells under chronic nutrient deprivation, and they reveal an unanticipated role of the miR-290-295 cluster in conferring a survival advantage to melanoma cells by inhibiting autophagic cell death. 2475 miR-294 mmu-miR-294-3p,mmu-miR-294-5p MIMAT0000372,MIMAT0004574 miRNA Ulk1 autophagy down Mus musculus melanoma cell lines 23150779 10090 22241 AU041434|Unc51.1|mKIAA0722 MGI:1270126|Ensembl:ENSMUSG00000029512 5 5|5 F unc-51 like kinase 1 protein-coding unc-51 like kinase 1 Autophagy mediates cell death of melanoma cells under chronic nutrient deprivation, and they reveal an unanticipated role of the miR-290-295 cluster in conferring a survival advantage to melanoma cells by inhibiting autophagic cell death.This was mediated by miR-290-295-induced downregulation of several essential autophagy genes, including Atg7 and ULK1, which resulted in inhibition of autophagic cell death induced by glucose starvation 2476 miR-295 mmu-miR-295-5p,mmu-miR-295-3p MIMAT0004575,MIMAT0000373 miRNA Atg7 autophagy down Mus musculus melanoma cell 23150779 10090 74244 1810013K23Rik|Agp7|Apg7l|Atg7l|Gm21553 MGI:1921494|Ensembl:ENSMUSG00000030314|Vega:OTTMUSG00000043567 6 6 E3|6 autophagy related 7 protein-coding autophagy related 7 Autophagy mediates cell death of melanoma cells under chronic nutrient deprivation, and they reveal an unanticipated role of the miR-290-295 cluster in conferring a survival advantage to melanoma cells by inhibiting autophagic cell death.This was mediated by miR-290-295-induced downregulation of several essential autophagy genes, including Atg7 and ULK1, which resulted in inhibition of autophagic cell death induced by glucose starvation 2477 miR-295 mmu-miR-295-5p,mmu-miR-295-3p MIMAT0004575,MIMAT0000373 miRNA Ulk1 autophagy down Mus musculus melanoma cell 23150779 10090 22241 AU041434|Unc51.1|mKIAA0722 MGI:1270126|Ensembl:ENSMUSG00000029512 5 5|5 F unc-51 like kinase 1 protein-coding unc-51 like kinase 1 Autophagy mediates cell death of melanoma cells under chronic nutrient deprivation, and they reveal an unanticipated role of the miR-290-295 cluster in conferring a survival advantage to melanoma cells by inhibiting autophagic cell death.This was mediated by miR-290-295-induced downregulation of several essential autophagy genes, including Atg7 and ULK1, which resulted in inhibition of autophagic cell death induced by glucose starvation 2478 miR-30a mmu-miR-30a-5p,mmu-miR-30a-3p MIMAT0000128,MIMAT0000129 miRNA Becn1 autophagy Mus musculus brain 24771295 10090 56208 4921513J16Rik|5430417M23Rik|Atg6 MGI:1891828 11 11 D|11 beclin 1, autophagy related protein-coding beclin 1, autophagy related The down-regulated miRNA-30a could attenuate 1 h OGD/24 h reoxygenation-induced ischemic injury in N2A cells and cultured cortical neurons through enhancing Beclin 1-mediated autophagy, as miRNA-30a recognized the 3'-untranslated region of beclin 1 mRNA to negatively regulate Beclin 1-protein level via promoting beclin 1 messenger RNA (mRNA) degradation, and Beclin 1 siRNA abolished anti-miR-30a-induced neuroprotection in 1 h OGD/24 h reoxygenation treated N2A cells. 2479 miR-325 mmu-miR-325-5p,mmu-miR-325-3p MIMAT0000558,MIMAT0004640 miRNA Arc autophagy down Mus musculus cardiomyocytes 24531537 10090 11838 Arc3.1|C86064|arg3.1|mArc MGI:88067|Ensembl:ENSMUSG00000022602|Vega:OTTMUSG00000016386 15 15 D3|15 34.25 cM activity regulated cytoskeletal-associated protein protein-coding activity regulated cytoskeletal-associated protein The suppression of ARC by miR-325 led to its inability to repress autophagic program. In exploring the molecular mechanism by which miR-325 expression is regulated, our results revealed that the transcription factor E2F1 contributed to promote miR-325 expression. E2F1 null mice demonstrated reduced autophagy and myocardial infarction sizes upon ischemia/reperfusion. Our present study reveals a novel autophagic regulating model that is composed of E2F1, miR-325 and ARC. Modulation of their levels may provide a new approach for tackling cardiac failure. 2480 miR-325 mmu-miR-325-5p,mmu-miR-325-3p MIMAT0000558,MIMAT0004640 miRNA E2f1 autophagy up Mus musculus cardiomyocytes 24531537 10090 13555 E2F-1|mKIAA4009 MGI:101941|Ensembl:ENSMUSG00000027490|Vega:OTTMUSG00000015917 2 2 H1|2 76.79 cM E2F transcription factor 1 protein-coding E2F transcription factor 1 The suppression of ARC by miR-325 led to its inability to repress autophagic program. In exploring the molecular mechanism by which miR-325 expression is regulated, our results revealed that the transcription factor E2F1 contributed to promote miR-325 expression. E2F1 null mice demonstrated reduced autophagy and myocardial infarction sizes upon ischemia/reperfusion. Our present study reveals a novel autophagic regulating model that is composed of E2F1, miR-325 and ARC. Modulation of their levels may provide a new approach for tackling cardiac failure. 2481 miR-93 mmu-miR-93-5p,hsa-miR-93-3p MIMAT0000540,MIMAT0004509 miRNA Sqstm1 autophagy down Mus musculus hematopoietic cells 21628417 10090 18412 A170|OSF-6|Osi|STAP|STONE14|p62 MGI:107931|Ensembl:ENSMUSG00000015837|Vega:OTTMUSG00000005574 11 11|11 B1.2 sequestosome 1 protein-coding sequestosome 1 Here, we show that ectopic expression o miR-17, -20,-93 and -106, all AAAGUGC seed-containing miRNAs, increases proliferation, colony outgrowth and replating capacity of myeloid progenitors an results in enhanced P-ERK levels. Quantitative proteomics identified sequestosome 1 (SQSTM1), an ubiquitin-binding protein and regulator of autophagy mediated protein degradation, as a major target for these miRNAs in myeloid progenitors. 2482 miR-99a mmu-miR-99a-5p,mmu-miR-99a-3p MIMAT0000131,MIMAT0016981 miRNA autophagy Mus musculus ventricular myocytes 24628978 10090 Our results demonstrate that miR-99a overexpression improves both cardiac function and survival ratio in a murine model of MI by preventing cell apoptosis and increasing autophagy via an mTOR/P70/S6K signalling pathway. 2483 miR-34a mmu-miR-34a-5p,mmu-miR-34a-3p MIMAT0000542,MIMAT0017022 miRNA Atg9a autophagy down Mus musculus neural stem cell 24973144 10090 245860 AU019532|Apg9l1|Atg9|Atg9l1 MGI:2138446|Ensembl:ENSMUSG00000033124 1 1 C3|1 autophagy related 9A protein-coding autophagy related 9A In addition, synaptotagmin 1 (Syt1) and autophagy-related 9a (Atg9a) significantly increased during neurogenesis. Pharmacological inhibition of autophagy impaired both neuronal differentiation and cell morphology. Notably, we showed that Syt1 and Atg9a are miR-34a targets in neural differentiation context, markedly decreasing after miR-34a overexpression. Syt1 overexpression and rapamycin-induced autophagy partially rescued the impairment of neuronal differentiation by miR-34a.? 2484 lincRNA-EPS http://lncrna.com/lincrna-eps/ lncRNA Pycard apoptosis down Mus musculus erythroid cells 22155924 10090 66824 9130417A21Rik|Asc|CARD5|TMS-1|TNS1|masc MGI:1931465 7 7|7 F4 PYD and CARD domain containing protein-coding PYD and CARD domain containing PYD and CARD domain-cont LncRNA-EPS,this lncRNA represses expression of Pycard, a proapoptotic gene, explaining in part the inhibition of programmed cell death. These findings reveal a novel layer of regulation of cell differentiation and apoptosis by a lncRNA 2485 lincRNA-p21 http://lncrna.com/lincRNA-p21/ lncRNA Perp apoptosis up Mus musculus embryonic fibroblasts 20673990 10090 64058 1110017A08Rik|KCP1|KRTCAP1|PIGPC1|THW MGI:1929938|Ensembl:ENSMUSG00000019851 10 10|10 A2 PERP, TP53 apoptosis effector protein-coding PERP, TP53 apoptosis effector G2/M phase-specific E3 ub We observed that both lincRNA-p21 and p53 knockdowns resulted in the repression of apoptosis genes (Noxa and Perp) and derepression of cell survival genes (Bcl2l3, Stat3 and Atf2 among others)? 2486 lincRNA-p21 http://lncrna.com/lincRNA-p21/ lncRNA Pmaip1 apoptosis up Mus musculus embryonic fibroblasts 20673990 10090 58801 Noxa MGI:1930146|Ensembl:ENSMUSG00000024521 18 18 E1|18 phorbol-12-myristate-13-acetate-induced protein 1 protein-coding phorbol-12-myristate-13-acetate-induced protein 1 cAMP response element-bin We observed that both lincRNA-p21 and p53 knockdowns resulted in the repression of apoptosis genes (Noxa and Perp) and derepression of cell survival genes (Bcl2l3, Stat3 and Atf2 among others)? 2487 msur1 http://www.lncrnadb.org/Detail.aspx?TKeyID=167 lncRNA Sod1 apoptosis down Mus musculus various tissues 17957031 10090 20655 B430204E11Rik|Cu/Zn-SOD|CuZnSOD|Ipo-1|Ipo1|SODC|Sod-1 MGI:98351|Ensembl:ENSMUSG00000022982 16 16 B5-C3|16 51.56 cM superoxide dismutase 1, soluble protein-coding superoxide dismutase 1, soluble Cu(2+)-Zn2+ superoxide di In vitro expression experiments show that MSUR1 is able to rescue SOD1(G93A)-mediated cell death. Expression of MSUR1 significantly reduces SOD1(G93A)-induced free radical levels and oxidative damage. 2488 peg13 http://www.valadkhanlab.org/web/cgi-bin/output_1.cgi?name=Peg13&genome lncRNA Kcnk9 apoptosis Mus musculus brain 17704508 10090 223604 Task3 MGI:3521816|Ensembl:ENSMUSG00000036760 15 15 D3|15 potassium channel, subfamily K, member 9 protein-coding potassium channel, subfamily K, member 9 TWIK-related acid-sensiti Kcnk9 imprinting may be regulated by the maternal germline differentially methylated region in Peg13, an imprinted non-coding RNA gene in close proximity to Kcnk9 on distal mouse chromosome 15. 2489 rncr3 http://www.lncrnadb.org/Detail.aspx?TKeyID=127 lncRNA apoptosis Mus musculus central nervous system 21857657 10090 Rncr3(-/-) mice exhibited abnormalities in the CNS, including small brain size, axonal mis-sprouting of dentate gyrus granule cells and retinal cone cell death. 2490 Smad7 lncRNA Tgfb1 apoptosis up Mus musculus breast cancer JygMC(A) cell 24863656 10090 21803 TGF-beta1|TGFbeta1|Tgfb|Tgfb-1 MGI:98725|Ensembl:ENSMUSG00000002603|Vega:OTTMUSG00000036027 7 7 A3|7 13.98 cM transforming growth factor, beta 1 protein-coding transforming growth factor, beta 1 LncRNA-Smad7 was located adjacent to the mouse Smad7 gene, and its expression was induced by TGF-¦Â in all of the mouse mammary gland epithelial cell lines and breast cancer cell lines that we evaluated. Suppression of lncRNA-Smad7 expression cancelled the anti-apoptotic function of TGF-¦Â. In contrast, forced expression of lncRNA-Smad7 rescued apoptosis induced by a TGF-¦Â type I receptor kinase inhibitor in the mouse breast cancer cell line JygMC(A). 2491 sra http://www.lncrnadb.org/Detail.aspx?TKeyID=117 lncRNA apoptosis down Mus musculus luminal epithelial cells of the mammary gland 14517287 10090 Steroid receptor RNA activator stimulates proliferation as well as apoptosis in vivo. 2492 Tsx lncRNA apoptosis Mus musculus 21912526 10090 Targeted deletion of Tsx generates viable offspring and X-inactivation is only mildly affected in embryonic stem cells. However, mutant embryonic stem cells are severely growth-retarded, differentiate poorly, and show elevated cell death. Furthermore, male mice have smaller testes resulting from pachytene-specific apoptosis and a maternal-specific effect results in slightly smaller litters. 2493 Xist http://www.lncrnadb.org/Detail.aspx?TKeyID=122 lncRNA apoptosis Mus musculus coelomic epithelial cells 9074937 10090 When changes associated with apoptosis of mesonephric tubules in the developing urogenital ridges are taken into account, expression of the Xist (X inactive specific transcript) gene correlates with X inactivation revealed by loss of beta-galactosidase activity in very early mesonephric tubule epithelial cells, gonadal interstitial mesenchymal cells and coelomic epithelial cells. 2494 miR-1 mmu-miR-1a-3p,mmu-miR-1b-5p MIMAT0000123,MIMAT0005835 miRNA Hspa1b apoptosis down Mus musculus MC3T3-E1 Cells 25678843 10090 15511 Hsp70|Hsp70-1|Hsp70.1|hsp68 MGI:99517|Ensembl:ENSMUSG00000090877|Vega:OTTMUSG00000037920 17 17 B1|17 18.5 cM heat shock protein 1B protein-coding heat shock protein 1B Therefore, this study showed that miR-1 participates in NO-induced apoptotic insults through targeting HSP-70 gene expression.Downregulation of miR-1 expression simultaneously lessened SNP-induced inhibition of HSP-70 mRNA and protein expressions. 2495 miR-101a mmu-miR-101a-5p,mmu-miR-101a-3p MIMAT0004526,MIMAT0000133 miRNA apoptosis Mus musculus nonylphenol -treated Sertoli cells 21914226 10090 Comprehensiveanalysis of predicted target genes for miRNAs showed that the expression of genes with roles in cell proliferation, the cell cycle, and cell death were regulated by miRNA in NP-treated TM4 cells. 2496 miR-1188 mmu-miR-1188-5p,mmu-miR-1188-3p MIMAT0005843,MIMAT0017328 miRNA Bax apoptosis up Mus musculus hepatoma cell 25694452 10090 12028 - MGI:99702|Ensembl:ENSMUSG00000003873 7 7 B5|7 29.32 cM BCL2-associated X protein protein-coding BCL2-associated X protein Moreover, overexpressed miR-1188 promoted apoptosis, enhanced caspase-3 activity, and also upregulated the expression of Bax and p53. MiR-1188 directly targeted and negatively regulated Bcl-2 and Sp1. Silencing of Bcl-2 and Sp1 exactly copied the proapoptotic and anti-invasive effect of miR-1188, respectively. Meanwhile, the expression of apoptosis and invasion-related genes such as Vegfa, Fgfr1, and Rprd1b was decreased following enhancement of miR-1188, as determined by gene expression profiling analysis. 2497 miR-1188 mmu-miR-1188-5p,mmu-miR-1188-3p MIMAT0005843,MIMAT0017328 miRNA Bcl2 apoptosis down Mus musculus hepatoma cell 25694452 10090 12043 AW986256|Bcl-2|C430015F12Rik|D630044D05Rik|D830018M01Rik MGI:88138|Ensembl:ENSMUSG00000057329|Vega:OTTMUSG00000022128 1 1 E2.1|1 49.76 cM B cell leukemia/lymphoma 2 protein-coding B cell leukemia/lymphoma 2 Moreover, overexpressed miR-1188 promoted apoptosis, enhanced caspase-3 activity, and also upregulated the expression of Bax and p53. MiR-1188 directly targeted and negatively regulated Bcl-2 and Sp1. Silencing of Bcl-2 and Sp1 exactly copied the proapoptotic and anti-invasive effect of miR-1188, respectively. Meanwhile, the expression of apoptosis and invasion-related genes such as Vegfa, Fgfr1, and Rprd1b was decreased following enhancement of miR-1188, as determined by gene expression profiling analysis. 2498 miR-1188 mmu-miR-1188-5p,mmu-miR-1188-3p MIMAT0005843,MIMAT0017328 miRNA Casp3 apoptosis up Mus musculus hepatoma cell 25694452 10090 12367 A830040C14Rik|AC-3|Apopain|CASP-3|CC3|CPP-32|CPP32|Caspase-3|Lice|SCA-1|Yama|mldy MGI:107739 8 8 B1.1|8 26.39 cM caspase 3 protein-coding caspase 3 Moreover, overexpressed miR-1188 promoted apoptosis, enhanced caspase-3 activity, and also upregulated the expression of Bax and p53. MiR-1188 directly targeted and negatively regulated Bcl-2 and Sp1. Silencing of Bcl-2 and Sp1 exactly copied the proapoptotic and anti-invasive effect of miR-1188, respectively. Meanwhile, the expression of apoptosis and invasion-related genes such as Vegfa, Fgfr1, and Rprd1b was decreased following enhancement of miR-1188, as determined by gene expression profiling analysis. 2499 miR-1188 mmu-miR-1188-5p,mmu-miR-1188-3p MIMAT0005843,MIMAT0017328 miRNA Sp1 apoptosis down Mus musculus hepatoma cell 25694452 10090 20683 1110003E12Rik|AA450830|AI845540|Sp1-1 MGI:98372|Ensembl:ENSMUSG00000001280|Vega:OTTMUSG00000035159 15 15 F3|15 trans-acting transcription factor 1 protein-coding trans-acting transcription factor 1 Moreover, overexpressed miR-1188 promoted apoptosis, enhanced caspase-3 activity, and also upregulated the expression of Bax and p53. MiR-1188 directly targeted and negatively regulated Bcl-2 and Sp1. Silencing of Bcl-2 and Sp1 exactly copied the proapoptotic and anti-invasive effect of miR-1188, respectively. Meanwhile, the expression of apoptosis and invasion-related genes such as Vegfa, Fgfr1, and Rprd1b was decreased following enhancement of miR-1188, as determined by gene expression profiling analysis. 2500 miR-1188 mmu-miR-1188-5p,mmu-miR-1188-3p MIMAT0005843,MIMAT0017328 miRNA Trp53 apoptosis up Mus musculus hepatoma cell 25694452 10090 22059 Tp53|bbl|bfy|bhy|p44|p53 MGI:98834|Ensembl:ENSMUSG00000059552|Vega:OTTMUSG00000005982 11 11 B2-C|11 42.83 cM transformation related protein 53 protein-coding transformation related protein 53 Moreover, overexpressed miR-1188 promoted apoptosis, enhanced caspase-3 activity, and also upregulated the expression of Bax and p53. MiR-1188 directly targeted and negatively regulated Bcl-2 and Sp1. Silencing of Bcl-2 and Sp1 exactly copied the proapoptotic and anti-invasive effect of miR-1188, respectively. Meanwhile, the expression of apoptosis and invasion-related genes such as Vegfa, Fgfr1, and Rprd1b was decreased following enhancement of miR-1188, as determined by gene expression profiling analysis. 2501 miR-124 mmu-miR-124-5p,mmu-miR-124-3p MIMAT0004527,MIMAT0000134 miRNA Ppp1r13l apoptosis down Mus musculus brain cells 23696548 10090 333654 AV260376|IASPP|Nkip1|wa3 MGI:3525053|Ensembl:ENSMUSG00000040734|Vega:OTTMUSG00000029180 7 7 A3|7 9.62 cM protein phosphatase 1, regulatory (inhibitor) subunit 13 like protein-coding protein phosphatase 1, regulatory (inhibitor) subunit 13 like MicroRNA-124-Mediated Regulation of Inhibitory Member of Apoptosis-Stimulating Protein of p53 Family in Experimental Stroke.infusion of miR-124 decreased brain levels of iASPP, whereas inhibition of miR-124 enhanced iASPP levels and significantly reduced infarction in mouse focal cerebral ischemia. 2502 miR-124a mmu-miR-124-5p,mmu-miR-124-3p MIMAT0004527,MIMAT0000134 miRNA Lhx2 apoptosis down Mus musculus central nervous system 21857657 10090 16870 LH2A|Lh-2|Lim2|ap|apterous MGI:96785|Ensembl:ENSMUSG00000000247|Vega:OTTMUSG00000012866 2 2 B|2 LIM homeobox protein 2 protein-coding LIM homeobox protein 2 We found that Lhx2 is an in vivo target mRNA of miR-124a. We also observed that LHX2 downregulation by miR-124a is required for the prevention of apoptosis in the developing retina and proper axonal development of hippocampal neurons. 2503 miR-125a mmu-miR-125a-5p,mmu-miR-125a-3p MIMAT0000135,MIMAT0004528 miRNA Mcl1 apoptosis down Mus musculus paclitaxel-resistant colon cancer stem cells 23327190 10090 17210 AW556805|Mcl-1 MGI:101769|Ensembl:ENSMUSG00000038612 3 3 F2.1|3 40.74 cM myeloid cell leukemia sequence 1 protein-coding myeloid cell leukemia sequence 1 Overexpression of miR-125a/b significantly inhibited ALDH1A3 and Mcl1 expression, reduced cell survival, and increased cell apoptosis in HT29-taxol cells. 2504 miR-125a-3p mmu-miR-125a-3p MIMAT0004528 miRNA Sod1 apoptosis up Mus musculus sertoli cells 20467044 10090 20655 B430204E11Rik|Cu/Zn-SOD|CuZnSOD|Ipo-1|Ipo1|SODC|Sod-1 MGI:98351|Ensembl:ENSMUSG00000022982 16 16 B5-C3|16 51.56 cM superoxide dismutase 1, soluble protein-coding superoxide dismutase 1, soluble Furthermore, through 3'UTR luciferase assays we identified one up-regulated protein, SOD-1, a Cu/Zn superoxide dismutase whose overexpression has been linked to enhanced cell death through apoptosis, as a likely direct target of three Sertoli cell-expressed miRNAs, miR-125a-3p, miR-872 and miR-24. 2505 miR-125a-3p mmu-miR-125a-3p MIMAT0004528 miRNA apoptosis Mus musculus nonylphenol -treated Sertoli cells 21914226 10090 Comprehensiveanalysis of predicted target genes for miRNAs showed that the expression of genes with roles in cell proliferation, the cell cycle, and cell death were regulated by miRNA in NP-treated TM4 cells. 2506 miR-125b mmu-miR-125b-5p,mmu-miR-125b-2-3p,mmu-miR-125b-1-3p MIMAT0000136,MIMAT0004529,MIMAT0004669 miRNA Mcl1 apoptosis down Mus musculus paclitaxel-resistant colon cancer stem cells 23327190 10090 17210 AW556805|Mcl-1 MGI:101769|Ensembl:ENSMUSG00000038612 3 3 F2.1|3 40.74 cM myeloid cell leukemia sequence 1 protein-coding myeloid cell leukemia sequence 1 Overexpression of miR-125a/b significantly inhibited ALDH1A3 and Mcl1 expression, reduced cell survival, and increased cell apoptosis in HT29-taxol cells. 2507 miR-125b mmu-miR-125b-5p,mmu-miR-125b-2-3p,mmu-miR-125b-1-3p MIMAT0000136,MIMAT0004529,MIMAT0004669 miRNA Tnf apoptosis down Mus musculus macrophages 17911593 10090 21926 DIF|TNF-a|TNF-alpha|TNFSF2|TNFalpha|Tnfa|Tnfsf1a MGI:104798|Ensembl:ENSMUSG00000024401|Vega:OTTMUSG00000037196 17 17 B1|17 18.59 cM tumor necrosis factor protein-coding tumor necrosis factor TNF alpha|TNF-a|cachectin Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock. 2508 miR-125b mmu-miR-125b-5p,mmu-miR-125b-2-3p,mmu-miR-125b-1-3p MIMAT0000136,MIMAT0004529,MIMAT0004669 miRNA apoptosis Mus musculus hematopoietic cells 22456625 10090 Targets of miR-125b include key proteins regulating apoptosis, innate immunity, inflammation and hematopoietic differentiation. 2509 miR-126 mmu-miR-126a-5p,mmu-miR-126a-3p,mmu-miR-126b-5p,mmu-miR-126b-3p MIMAT0000137,MIMAT0000138,MIMAT0029894,MIMAT0029895 miRNA Cxcl12 apoptosis down Mus musculus cardiomyocytic cells 19996457 10090 20315 Pbsf|Scyb12|Sdf1|Tlsf|Tpar1 MGI:103556|Ensembl:ENSMUSG00000061353|Vega:OTTMUSG00000022768 6 6 F1|6 54.81 cM chemokine (C-X-C motif) ligand 12 protein-coding chemokine (C-X-C motif) ligand 12 CXCL12 production was mediated by microRNA-126 (miR-126), which was enriched in apoptotic bodies and repressed the function of regulator of G protein (heterotrimeric guanosine triphosphate-binding protein) signaling 16, an inhibitor of G protein-coupled receptor (GPCR) signaling. This enabled CXCR4, a GPCR, to trigger an autoregulatory feedback loop that increased the production of CXCL12. 2510 miR-133 mmu-miR-134-5p,mmu-miR-134-3p MIMAT0000146,MIMAT0016985 miRNA Adrb1 apoptosis up Mus musculus 24807785 10090 11554 Adrb-1|beta-AR MGI:87937|Ensembl:ENSMUSG00000035283 19 19 D2|19 51.96 cM adrenergic receptor, beta 1 protein-coding adrenergic receptor, beta 1 Consistently, cAMP accumulation and activation of downstream targets were repressed by miR-133 overexpression in both neonatal and adult cardiomyocytes following selective ¦Â1AR stimulation. Furthermore, gain-of-function and loss-of-function studies of miR-133 revealed its role in counteracting the deleterious apoptotic effects caused by chronic ¦Â1AR stimulation. This was confirmed in vivo using a novel cardiac-specific TetON-miR-133 inducible transgenic mouse model. 2511 miR-133 mmu-miR-133a-3p,mmu-miR-133b-3p,mmu-miR-133a-5p,mmu-miR-133b-5p,mmu-mi MIMAT0000145,MIMAT0000769,MIMAT0003473,MIMAT001708 miRNA Camp apoptosis down Mus musculus 24807785 10090 12796 CAP18|Cnlp|Cramp|FALL39|MCLP MGI:108443|Ensembl:ENSMUSG00000038357|Vega:OTTMUSG00000020575 9 9 F2|9 59.8 cM cathelicidin antimicrobial peptide protein-coding cathelicidin antimicrobial peptide Consistently, cAMP accumulation and activation of downstream targets were repressed by miR-133 overexpression in both neonatal and adult cardiomyocytes following selective ¦Â1AR stimulation. Furthermore, gain-of-function and loss-of-function studies of miR-133 revealed its role in counteracting the deleterious apoptotic effects caused by chronic ¦Â1AR stimulation. This was confirmed in vivo using a novel cardiac-specific TetON-miR-133 inducible transgenic mouse model. 2512 miR-134 mmu-miR-134-5p,mmu-miR-134-3p MIMAT0000146,MIMAT0016985 miRNA Creb1 apoptosis up Mus musculus primary Hippocampal cell 25645685 10090 12912 2310001E10Rik|3526402H21Rik|AV083133|Creb|Creb-1 MGI:88494|Ensembl:ENSMUSG00000025958 1 1 C2|1 32.74 cM cAMP responsive element binding protein 1 protein-coding cAMP responsive element binding protein 1 CAMP response element-binding protein (CREB) plays a pivotal role in preventing the apoptosis of neurons and many other cells. Here, we found that AMP-activated protein kinase (AMPK) and CREB are oppositely regulated in mouse primary hippocampal neurons impaired by hypoxia-hypoglycemia. AMPK overexpression reduced the CREB level by upregulating SIRT1 and was negatively posttranscriptionally regulated by miR-134, suggesting a negative regulatory role of AMPK in the expression of CREB. 2513 miR-134 mmu-miR-134-5p,mmu-miR-134-3p MIMAT0000146,MIMAT0016985 miRNA Hspa12b apoptosis down Mus musculus neuronal cell 25304362 10090 72630 2700081N06Rik MGI:1919880|Ensembl:ENSMUSG00000074793|Vega:OTTMUSG00000015727 2 2|2 F3 heat shock protein 12B protein-coding heat shock protein 12B The results showed that miR-134 expression levels increased in primary cultured neuronal cells and mouse brain from 12h to 7 day reoxygenation/reperfusion after 1h OGD or 1h MCAO treatment. miR-134 overexpression promoted neuronal cell death and apoptosis by decreasing HSPA12B protein levels. 2514 miR-134 miRNA Prkaa1 apoptosis down Mus musculus primary Hippocampal cell 25645685 10090 105787 AI194361|AI450832|AL024255|AMPKalpha1|C130083N04Rik MGI:2145955|Ensembl:ENSMUSG00000050697 15 15 A1|15 protein kinase, AMP-activated, alpha 1 catalytic subunit protein-coding protein kinase, AMP-activated, alpha 1 catalytic subunit CAMP response element-binding protein (CREB) plays a pivotal role in preventing the apoptosis of neurons and many other cells. Here, we found that AMP-activated protein kinase (AMPK) and CREB are oppositely regulated in mouse primary hippocampal neurons impaired by hypoxia-hypoglycemia. AMPK overexpression reduced the CREB level by upregulating SIRT1 and was negatively posttranscriptionally regulated by miR-134, suggesting a negative regulatory role of AMPK in the expression of CREB. 2515 miR-141 mmu-miR-141-3p,mmu-miR-141-5p MIMAT0000153 ,MIMAT0004533 miRNA Pten apoptosis down Mus musculus Endometrium cells 23825654 10090 19211 2310035O07Rik|A130070J02Rik|AI463227|B430203M17Rik|MMAC1|TEP1 MGI:109583|Ensembl:ENSMUSG00000013663|Vega:OTTMUSG00000021203 19 19 C1|19 28.14 cM phosphatase and tensin homolog protein-coding phosphatase and tensin homolog Reduced mmu-miR-141 could decrease the proliferation activity of stromal cells and promote apoptosis. Upregulation of mmu-miR-141 inhibited PTEN protein expression but downregulation of mmu-miR-141 increased it, while the mRNA level remained unchanged. 2516 miR-143 mmu-miR-143-5p,mmu-miR-143-3p MIMAT0017006,MIMAT0000247 miRNA Dicer1 apoptosis down Mus musculus Lung alveolar epithelial cell 25172909 10090 192119 1110006F08Rik|D12Ertd7e|mKIAA0928 MGI:2177178|Ensembl:ENSMUSG00000041415 12 12 E-F1|12 54.83 cM dicer 1, ribonuclease type III protein-coding dicer 1, ribonuclease type III The miR-143 and anti-miR-155 transfection resulted in a significant cell apoptosis. The expression of Dicer was decreased with HK2 accumulating in mouse lung tissues under hypoxia identified by immunohistochemistry. 2517 miR-144 mmu-miR-144-5p,mmu-miR-144-3p MIMAT0016988,MIMAT0000156 miRNA Pafah1b1 apoptosis down Mus musculus cholangiocarcinoma 25479763 10090 18472 LIS-1|Lis1|MMS10-U|Mdsh|Ms10u|Pafaha MGI:109520|Ensembl:ENSMUSG00000020745|Vega:OTTMUSG00000006184 11 11 B3|11 45.76 cM platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 protein-coding platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 The pcDNA3.1(+)-miR-223 vector efficiently suppressed the expression of HSP90B1, while silencing miR-223 increased expression of Hsp90B1. Furthermore, overexpression of miR-223 results in significant inhibition of cell growth on culture plates. Moreover, cancer cells showed significant G0/G1 arrest and increased apoptosis due to gene silencing. Protein levels of PI3k, p-Akt, mTOR, and Bcl-2 were decreased, whereas Bid levels were increased. Microvessel density as assessed by CD34 levels and cell growth by PCNA levels decreased according to immunohistochemical analysis. 2518 miR-145 mmu-miR-145a-5p,mmu-miR-145a-3p MIMAT0000157,MIMAT0004534 miRNA Col5a1 apoptosis up Mus musculus meningioma cells 23108408 10090 12831 AI413331 MGI:88457|Ensembl:ENSMUSG00000026837|Vega:OTTMUSG00000011567 2 2 A2-B|2 19.38 cM collagen, type V, alpha 1 protein-coding collagen, type V, alpha 1 Moreover, meningioma cells with high miR-145 levels had impaired migratory and invasive potential in vitro and in vivo. PCR-array studies of miR145 overexpressing cells suggested that collagen type V alpha (COL5A1) expression is downregulated by miR-145 overexpression. 2519 miR-145 mmu-miR-145-5p,mmu-miR-145-3p MIMAT0000157,MIMAT0004534 miRNA Mapk7 apoptosis down Mus musculus colon carcinoma cells 21690566 10090 23939 BMK-1|BMK1|ERK-5|ERK5|Erk5-T|PRKM7 MGI:1346347|Ensembl:ENSMUSG00000001034|Vega:OTTMUSG00000005833 11 11 B2|11 mitogen-activated protein kinase 7 protein-coding mitogen-activated protein kinase 7 BMK-1; ERK-5; MAP kinase MiR-145 delivery reduced tumor proliferation and increased apoptosis, with concomitant repression of c-Myc and ERK5 as novel regulatory target of miR-145. 2520 miR-145 mmu-miR-145-5p,mmu-miR-145-3p MIMAT0000157,MIMAT0004534 miRNA Myc apoptosis down Mus musculus colon carcinoma cells 21690566 10090 17869 AU016757|Myc2|Niard|Nird|bHLHe39 MGI:97250|Ensembl:ENSMUSG00000022346|Vega:OTTMUSG00000034892 15 15 D2-D3|15 26.19 cM myelocytomatosis oncogene protein-coding myelocytomatosis oncogene c-myc proto-oncogene; myc MiR-145 delivery reduced tumor proliferation and increased apoptosis, with concomitant repression of c-Myc and ERK5 as novel regulatory target of miR-145. 2521 miR-146a mmu-miR-146a-5p,mmu-miR-146a-3p MIMAT0000158,MIMAT0016989 miRNA Erbb4 apoptosis down Mus musculus cardiomyocytes 20495188 10090 13869 Her4|c-erbB-4 MGI:104771|Ensembl:ENSMUSG00000062209|Vega:OTTMUSG00000025138 1 1 C3|1 33.8 cM v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) protein-coding v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) avian erythroblastosis on After Dox treatment, overexpression of miR-146a, as well as that of siRNA against ErbB4, induced cell death in cardiomyocytes. 2522 miR-146a mmu-miR-146a-5p,mmu-miR-146a-3p MIMAT0000158,MIMAT0016989 miRNA Nos2 apoptosis down Mus musculus renal cell carcinoma cells 20709800 10090 18126 NOS-II|Nos-2|Nos2a|i-NOS|iNOS MGI:97361|Ensembl:ENSMUSG00000020826|Vega:OTTMUSG00000000146 11 11 B5|11 46.74 cM nitric oxide synthase 2, inducible protein-coding nitric oxide synthase 2, inducible MAC-NOS; NOS type II; ind In addition to NO production by macrophages, tumor cells must produce NO to induce their own deaths, and some tumor cells may use miR-146a to reduce or abolish endogenous NO production to escape macrophage-mediated cell death. 2523 miR-146b mmu-miR-146b-5p,mmu-miR-146b-3p MIMAT0003475,MIMAT0004826 miRNA Foxp3 apoptosis up Mus musculus prostate cancer cell 25712341 10090 20371 JM2|scurfin|sf MGI:1891436|Ensembl:ENSMUSG00000039521|Vega:OTTMUSG00000016624 X X A1.1|X 3.41 cM forkhead box P3 protein-coding forkhead box P3 We observed that FOXP3 dramatically induced the expression of miR-146a/b, which contributed to transcriptional inhibition of IRAK1 and TRAF6, in prostate cancer cell lines. Tissue-specific deletion of Foxp3 in mouse prostate caused a significant reduction of miR-146a and upregulation of NF-¦ÊB activation. In addition, prostatic intraepithelial neoplasia lesions were observed in miR-146a mutant mice as well as in Foxp3 mutant mice. Notably, the NF-¦ÊB inhibitor bortezomib inhibited cell proliferation and induced apoptosis in prostate epithelial cells, attenuating prostatic intraepithelial neoplasia formation in Foxp3 mutant mice. Our data suggest that the FOXP3-miR-146-NF-¦ÊB axis has a functional role during tumor initiation in prostate cancer. 2524 miR-146b mmu-miR-146b-5p,mmu-miR-146b-3p MIMAT0003475,MIMAT0004826 miRNA Irak1 apoptosis down Mus musculus prostate cancer cell 25712341 10090 16179 AA408924|IRAK|IRAK-1|IRAK1-S|Il1rak|Plpk|mPLK MGI:107420|Ensembl:ENSMUSG00000031392|Vega:OTTMUSG00000017687 X X A7.3|X 37.61 cM interleukin-1 receptor-associated kinase 1 protein-coding interleukin-1 receptor-associated kinase 1 We observed that FOXP3 dramatically induced the expression of miR-146a/b, which contributed to transcriptional inhibition of IRAK1 and TRAF6, in prostate cancer cell lines. Tissue-specific deletion of Foxp3 in mouse prostate caused a significant reduction of miR-146a and upregulation of NF-¦ÊB activation. In addition, prostatic intraepithelial neoplasia lesions were observed in miR-146a mutant mice as well as in Foxp3 mutant mice. Notably, the NF-¦ÊB inhibitor bortezomib inhibited cell proliferation and induced apoptosis in prostate epithelial cells, attenuating prostatic intraepithelial neoplasia formation in Foxp3 mutant mice. Our data suggest that the FOXP3-miR-146-NF-¦ÊB axis has a functional role during tumor initiation in prostate cancer. 2525 miR-146b mmu-miR-146b-5p,mmu-miR-146b-3p MIMAT0003475,MIMAT0004826 miRNA Nfkb1 apoptosis down Mus musculus prostate cancer cell 25712341 10090 18033 NF-KB1|NF-kappaB|NF-kappaB1|p105|p50|p50/p105 MGI:97312|Ensembl:ENSMUSG00000028163|Vega:OTTMUSG00000016668 3 3 G3|3 62.82 cM nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 protein-coding nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 We observed that FOXP3 dramatically induced the expression of miR-146a/b, which contributed to transcriptional inhibition of IRAK1 and TRAF6, in prostate cancer cell lines. Tissue-specific deletion of Foxp3 in mouse prostate caused a significant reduction of miR-146a and upregulation of NF-¦ÊB activation. In addition, prostatic intraepithelial neoplasia lesions were observed in miR-146a mutant mice as well as in Foxp3 mutant mice. Notably, the NF-¦ÊB inhibitor bortezomib inhibited cell proliferation and induced apoptosis in prostate epithelial cells, attenuating prostatic intraepithelial neoplasia formation in Foxp3 mutant mice. Our data suggest that the FOXP3-miR-146-NF-¦ÊB axis has a functional role during tumor initiation in prostate cancer. 2526 miR-146b mmu-miR-146b-5p,mmu-miR-146b-3p MIMAT0003475,MIMAT0004826 miRNA Traf6 apoptosis down Mus musculus prostate cancer cell 25712341 10090 22034 2310003F17Rik|AI851288|C630032O20Rik MGI:108072|Ensembl:ENSMUSG00000027164|Vega:OTTMUSG00000014586 2 2 E2|2 TNF receptor-associated factor 6 protein-coding TNF receptor-associated factor 6 We observed that FOXP3 dramatically induced the expression of miR-146a/b, which contributed to transcriptional inhibition of IRAK1 and TRAF6, in prostate cancer cell lines. Tissue-specific deletion of Foxp3 in mouse prostate caused a significant reduction of miR-146a and upregulation of NF-¦ÊB activation. In addition, prostatic intraepithelial neoplasia lesions were observed in miR-146a mutant mice as well as in Foxp3 mutant mice. Notably, the NF-¦ÊB inhibitor bortezomib inhibited cell proliferation and induced apoptosis in prostate epithelial cells, attenuating prostatic intraepithelial neoplasia formation in Foxp3 mutant mice. Our data suggest that the FOXP3-miR-146-NF-¦ÊB axis has a functional role during tumor initiation in prostate cancer. 2527 miR-149 mmu-miR-149-5p,mmu-miR-149-3p MIMAT0000159,MIMAT0016990 miRNA Gsk3a apoptosis Mus musculus melanoma cells 21896753 10090 606496 2700086H06Rik MGI:2152453|Ensembl:ENSMUSG00000057177|Vega:OTTMUSG00000021123 7 7 A3|7 glycogen synthase kinase 3 alpha protein-coding glycogen synthase kinase 3 alpha P53 directly up-regulates microRNA-149* (miR-149*) that in turn targets glycogen synthase kinase-3¦Á, resulting in increased expression of Mcl-1 and resistance to apoptosis in melanoma cells. 2528 miR-149 mmu-miR-149-5p,mmu-miR-149-3p MIMAT0000159,MIMAT0016990 miRNA Mcl1 apoptosis up Mus musculus melanoma cells 21896753 10090 17210 AW556805|Mcl-1 MGI:101769|Ensembl:ENSMUSG00000038612 3 3 F2.1|3 40.74 cM myeloid cell leukemia sequence 1 protein-coding myeloid cell leukemia sequence 1 P53 directly up-regulates microRNA-149* (miR-149*) that in turn targets glycogen synthase kinase-3¦Á, resulting in increased expression of Mcl-1 and resistance to apoptosis in melanoma cells. 2529 miR-149 mmu-miR-149-5p,mmu-miR-149-3p MIMAT0000159,MIMAT0016990 miRNA Trp53 apoptosis Mus musculus melanoma cells 21896753 10090 22059 Tp53|bbl|bfy|bhy|p44|p53 MGI:98834|Ensembl:ENSMUSG00000059552|Vega:OTTMUSG00000005982 11 11 B2-C|11 42.83 cM transformation related protein 53 protein-coding transformation related protein 53 P53 directly up-regulates microRNA-149* (miR-149*) that in turn targets glycogen synthase kinase-3¦Á, resulting in increased expression of Mcl-1 and resistance to apoptosis in melanoma cells. 2530 miR-150 mmu-miR-150-5p,mmu-miR-150-3p MIMAT0000160,MIMAT0004535 miRNA Cxcr4 apoptosis down Mus musculus myocardial cell 25466411 10090 12767 CD184|Cmkar4|LESTR|PB-CKR|PBSF/SDF-1|Sdf1r|b2b220Clo MGI:109563|Ensembl:ENSMUSG00000045382|Vega:OTTMUSG00000020918 1 1 E4|1 56.43 cM chemokine (C-X-C motif) receptor 4 protein-coding chemokine (C-X-C motif) receptor 4 In vivo studies showed that overexpression of miR-150 in mice resulted in improved cardiac function, reduced myocardial infarction size, inhibition of apoptosis, and reduced inflammatory Ly-6C(high) monocyte invasion levels after AMI. Wild-type mice transplanted with miR-150 null (-/-) bone marrow cells could reverse this protective effect. Mechanistic studies demonstrated that miR-150 inhibited the expression of chemokine receptor 4 (CXCR4), thereby promoting monocyte migration. 2531 miR-155 mmu-miR-155-5p,mmu-miR-155-3p MIMAT0000165,MIMAT0016993 miRNA Cdc73 apoptosis up Mus musculus oral squamous cell carcinoma cells 23166327 10090 214498 8430414L16Rik|BC027756|C130030P16Rik|C81219|Hrpt2 MGI:2384876 1 1 F|1 62.52 cM cell division cycle 73, Paf1/RNA polymerase II complex component protein-coding cell division cycle 73, Paf1/RNA polymerase II complex component Conversely, the delivery of a miR-155 antagonist (antagomir-155) to KB cells overexpressing miR-155 resulted in increased CDC73 levels, decreased cell viability, increased apoptosis, and marked regression of xenografts in nude mice. 2532 miR-155 mmu-miR-155-5p,mmu-miR-155-3p MIMAT0000165,MIMAT0016993 miRNA Dicer1 apoptosis up Mus musculus Lung alveolar epithelial cell 25172909 10090 192119 1110006F08Rik|D12Ertd7e|mKIAA0928 MGI:2177178|Ensembl:ENSMUSG00000041415 12 12 E-F1|12 54.83 cM dicer 1, ribonuclease type III protein-coding dicer 1, ribonuclease type III The miR-143 and anti-miR-155 transfection resulted in a significant cell apoptosis. The expression of Dicer was decreased with HK2 accumulating in mouse lung tissues under hypoxia identified by immunohistochemistry. 2533 miR-155 mmu-miR-155-5p,mmu-miR-155-3p MIMAT0000165,MIMAT0016993 miRNA Fadd apoptosis down Mus musculus macrophages 17911593 10090 14082 Mort1/FADD MGI:109324 7 7 F5|7 88.85 cM Fas (TNFRSF6)-associated via death domain protein-coding Fas (TNFRSF6)-associated via death domain FAS-associated death doma Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock. 2534 miR-155 mmu-miR-155-5p,mmu-miR-155-3p MIMAT0000165,MIMAT0016993 miRNA Fos apoptosis down Mus musculus kidney cell 25015656 10090 14281 D12Rfj1|c-fos|cFos MGI:95574|Ensembl:ENSMUSG00000021250|Vega:OTTMUSG00000019764 12 12 D2|12 39.7 cM FBJ osteosarcoma oncogene protein-coding FBJ osteosarcoma oncogene Genome-wide expression profiling and bioinformatic analysis indicated the activation of a number of canonical signaling pathways relating to apoptosis and oxidative stress over the course of the injury, and identified potential upstream regulators of these effects. One predicted upstream regulator was c-Fos, which has two confirmed miR-155 binding sites in its 3' UTR and, therefore, can be directly regulated by miR-155. We established that the miR-155(-/-) mice had significantly higher levels of c-Fos mRNA and protein than the C57BL/6 mice at 72 h after cisplatin exposure. These data indicate a role for miR-155 in the cisplatin response and suggest that targeting of c-Fos could be investigated to reduce cisplatin-induced nephrotoxicity. 2535 miR-155 mmu-miR-155-5p,mmu-miR-155-3p MIMAT0000165,MIMAT0016993 miRNA Hdac4 apoptosis down Mus musculus na?ve B cells 23169640 10090 208727 4932408F19Rik|AI047285 MGI:3036234|Ensembl:ENSMUSG00000026313 1 1 D|1 histone deacetylase 4 protein-coding histone deacetylase 4 Furthermore, ectopic expression of HDAC4 in human-activated B-cell-type diffuse large B-cell lymphoma (DLBCL) cells results in reduced miR-155-induced proliferation, clonogenic potential, and increased apoptosis. 2536 miR-155 mmu-miR-155-5p,mmu-miR-155-3p MIMAT0000165,MIMAT0016993 miRNA Ripk1 apoptosis down Mus musculus macrophages 17911593 10090 19766 D330015H01Rik|RIP|Rinp|Rip1 MGI:108212|Ensembl:ENSMUSG00000021408|Vega:OTTMUSG00000035489 13 13 A3.3|13 14.01 cM receptor (TNFRSF)-interacting serine-threonine kinase 1 protein-coding receptor (TNFRSF)-interacting serine-threonine kinase 1 RIP-1|cell death protein Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock. 2537 miR-15a mmu-miR-15a-5p,mmu-miR-15a-3p MIMAT0000526,MIMAT0004624 miRNA Bcl2 apoptosis down Mus musculus synovium 19714650 10090 12043 AW986256|Bcl-2|C430015F12Rik|D630044D05Rik|D830018M01Rik MGI:88138|Ensembl:ENSMUSG00000057329|Vega:OTTMUSG00000022128 1 1 E2.1|1 49.76 cM B cell leukemia/lymphoma 2 protein-coding B cell leukemia/lymphoma 2 B-cell leukemia/lymphoma The induction of cell apoptosis after intraarticular injection of double-stranded miR-15a occurs through inhibition of the translation of Bcl-2 protein in arthritic synovium. 2538 miR-15b mmu-miR-15b-5p,mmu-miR-15b-3p MIMAT0000124,MIMAT0004521 miRNA Dedd apoptosis down Mus musculus CD8+ T cell 23517578 10090 21945 CASP8IP1|DEFT|Dedpro1|FLDED1|KE05 MGI:1333874|Ensembl:ENSMUSG00000013973|Vega:OTTMUSG00000021703 1 1 H2|1 79.34 cM death effector domain-containing protein-coding death effector domain-containing Transfection of CD8+ T cells with miRNA-15b mimics could prevent T cells from apoptosis by inhibiting the translation of DEDD (Death Effector Domain-containing DNA binding protein). 2539 miR-16 mmu-miR-16-5p,mmu-miR-16-1-3p,mmu-miR-16-2-3p MIMAT0000527,MIMAT0004625,MIMAT0017018 miRNA Mdm2 apoptosis Mus musculus chronic lymphocytic leukemia cells 19723889 10090 17246 1700007J15Rik|AA415488|Mdm-2 MGI:96952|Ensembl:ENSMUSG00000020184|Vega:OTTMUSG00000020921 10 10 C1-C3|10 66.32 cM transformed mouse 3T3 cell double minute 2 protein-coding transformed mouse 3T3 cell double minute 2 G1/S-specific cyclin-D1 Our experiments showed a reduction in protein levels of cyclin D1, a miR-15a/16 target and cell cycle regulator of G(1)/S transition, in the New Zealand Black cell line following miR-15a/16 addition. These microRNAs were shown to directly target the cyclin D1 3' untranslated region using a green fluorescent protein lentiviral expression system. miR-16 was also shown to augment apoptosis induction by nutlin, a mouse double minute 2 (MDM2) antagonist, and genistein, a tyrosine kinase inhibitor, when added to a B-1 cell line derived from multiple in vivo passages of malignant B-1 cells from New Zealand Black mice with CLL. 2540 miR-17 mmu-miR-17-5p,mmu-miR-17-3p MIMAT0000649,MIMAT0000650 miRNA E2f1 apoptosis down Mus musculus lymphoma cells 16096373 10090 13555 E2F-1|mKIAA4009 MGI:101941|Ensembl:ENSMUSG00000027490|Vega:OTTMUSG00000015917 2 2 H1|2 76.79 cM E2F transcription factor 1 protein-coding E2F transcription factor 1 transcription factor E2F1 MiR-17 cluster prevents excessive E2F1 activity, and thereby apoptosis, in response to activation of c-Myc. 2541 miR-17-3p mmu-miR-17-3p MIMAT0000650 miRNA Bcl2l11 apoptosis down Mus musculus CD4+ T cells 18327259 10090 12125 1500006F24Rik|Bim|Bod|bcl2-L-11 MGI:1197519|Ensembl:ENSMUSG00000027381|Vega:OTTMUSG00000015356 2 2|2 F3-G1 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) Bcl2 interacting mediator The miR-17-92 miRNA suppressed expression of the tumor suppressor PTEN and the proapoptotic protein Bim. 2542 miR-17-3p mmu-miR-17-3p MIMAT0000650 miRNA Pten apoptosis down Mus musculus CD4+ T cells 18327259 10090 19211 2310035O07Rik|A130070J02Rik|AI463227|B430203M17Rik|MMAC1|TEP1 MGI:109583|Ensembl:ENSMUSG00000013663|Vega:OTTMUSG00000021203 19 19 C1|19 28.14 cM phosphatase and tensin homolog protein-coding phosphatase and tensin homolog mutated in multiple advan The miR-17-92 miRNA suppressed expression of the tumor suppressor PTEN and the proapoptotic protein Bim. 2543 miR-17-5p mmu-miR-17-5p MIMAT0000649 miRNA Bcl2l11 apoptosis down Mus musculus CD4+ T cells 18327259 10090 12125 1500006F24Rik|Bim|Bod|bcl2-L-11 MGI:1197519|Ensembl:ENSMUSG00000027381|Vega:OTTMUSG00000015356 2 2|2 F3-G1 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) Bcl2 interacting mediator The miR-17-92 miRNA suppressed expression of the tumor suppressor PTEN and the proapoptotic protein Bim. 2544 miR-17-5p mmu-miR-17-5p MIMAT0000649 miRNA Pten apoptosis down Mus musculus CD4+ T cells 18327259 10090 19211 2310035O07Rik|A130070J02Rik|AI463227|B430203M17Rik|MMAC1|TEP1 MGI:109583|Ensembl:ENSMUSG00000013663|Vega:OTTMUSG00000021203 19 19 C1|19 28.14 cM phosphatase and tensin homolog protein-coding phosphatase and tensin homolog mutated in multiple advan The miR-17-92 miRNA suppressed expression of the tumor suppressor PTEN and the proapoptotic protein Bim. 2545 miR-17-5p mmu-miR-17-5p MIMAT0000649 miRNA Trp53inp1 apoptosis down Mus musculus human gastric cancer cells 23333058 10090 60599 2700057G22Rik|SIP|SIP18|SIP27|Stinp|Teap MGI:1926609|Ensembl:ENSMUSG00000028211|Vega:OTTMUSG00000004505 4 4|4 A1-A2 transformation related protein 53 inducible nuclear protein 1 protein-coding transformation related protein 53 inducible nuclear protein 1 Overexpression of miR-17-5p/20a promoted gastric cancer cell cycle progression and inhibited cell apoptosis, whereas knockdown of miR-17-5p/20a resulted in cell cycle arrest and increased apoptosis. p21 and tumour protein p53-induced nuclear protein 1 (TP53INP1) were validated as the targets of miR-17-5p/20a. 2546 miR-181 mmu-miR-181a-5p,mmu-miR-181a-1-3p,mmu-miR-181b-5p,mmu-miR-181c-5p,mmu-miR-181d-5p,mmu-miR-181a-2-3p,mmu-miR-181b-1-3p,mmu-miR-181c-3p,mmu-miR-181b-2-3p,mmu-miR-181d-3p MIMAT0000210,MIMAT0000660,MIMAT0000673,MIMAT0000674,MIMAT0004324,MIMAT0005443,MIMAT0017067,MIMAT0017068,MIMAT0017084,MIMAT0017264 miRNA Mecp2 apoptosis down Mus musculus astrocytes 23650073 10090 17257 1500041B07Rik|D630021H01Rik|Mbd5|WBP10 MGI:99918|Ensembl:ENSMUSG00000031393|Vega:OTTMUSG00000017654 X X A7.3|X 37.63 cM methyl CpG binding protein 2 protein-coding methyl CpG binding protein 2 We validated the mRNAs encoding MeCP2 and X-linked inhibitor of apoptosis as targets of miR-181 2547 miR-181 mmu-miR-181a-5p,mmu-miR-181a-1-3p,mmu-miR-181b-5p,mmu-miR-181c-5p,mmu-miR-181d-5p,mmu-miR-181a-2-3p,mmu-miR-181b-1-3p,mmu-miR-181c-3p,mmu-miR-181b-2-3p,mmu-miR-181d-3p MIMAT0000210,MIMAT0000660,MIMAT0000673,MIMAT0000674,MIMAT0004324,MIMAT0005443,MIMAT0017067,MIMAT0017068,MIMAT0017084,MIMAT0017264 miRNA Yy1 apoptosis down Mus musculus cervical cancer cell 25672374 10090 22632 AW488674|NF-E1 MGI:99150|Ensembl:ENSMUSG00000021264|Vega:OTTMUSG00000017257 12 12 F1|12 59.58 cM YY1 transcription factor protein-coding YY1 transcription factor In addition, miR-181 also suppressed tumor growth in the nude mice. At the molecular level, it was found that Yin Yang 1, an oncogene in several types of human cancer, was negatively regulated by miR-181. Therefore, the findings of the present study suggest that exogenous overexpression of miR-181 may be a potential approach for the treatment of CC in the future. 2548 miR-181a mmu-miR-181a-5p,mmu-miR-181a-2-3p,mmu-miR-181b-5p,mmu-miR-181b-1-3p,mmu-miR-181a-5p,mmu-miR-181a-1-3p,mmu-miR-181c-5p,mmu-miR-181c-3p,mmu-miR-181b-2-3p MIMAT0000210,MIMAT0005443,MIMAT0000673,MIMAT0017067,MIMAT0000210,MIMAT0000660,MIMAT0000674,MIMAT0017068,MIMAT0017084 miRNA Bcl2 apoptosis Mus musculus neuron 25433215 10090 12043 AW986256|Bcl-2|C430015F12Rik|D630044D05Rik|D830018M01Rik MGI:88138|Ensembl:ENSMUSG00000057329|Vega:OTTMUSG00000022128 1 1 E2.1|1 49.76 cM B cell leukemia/lymphoma 2 protein-coding B cell leukemia/lymphoma 2 Targets affected by miR-181a antagomir administered after stroke onset include BCL2 and X-linked inhibitor of apoptosis protein (XIAP). 2549 miR-181a mmu-miR-181a-5p,mmu-miR-181a-2-3p,mmu-miR-181b-5p,mmu-miR-181b-1-3p,mmu-miR-181a-5p,mmu-miR-181a-1-3p,mmu-miR-181c-5p,mmu-miR-181c-3p,mmu-miR-181b-2-3p MIMAT0000210,MIMAT0005443,MIMAT0000673,MIMAT0017067,MIMAT0000210,MIMAT0000660,MIMAT0000674,MIMAT0017068,MIMAT0017084 miRNA Xiap apoptosis Mus musculus neuron 25433215 10090 11798 1110015C02Rik|Aipa|Api3|Birc4|IAP3|ILP-1|MIHA|mXIAP MGI:107572|Ensembl:ENSMUSG00000025860|Vega:OTTMUSG00000017444 X X|X A3-A5 X-linked inhibitor of apoptosis protein-coding X-linked inhibitor of apoptosis Targets affected by miR-181a antagomir administered after stroke onset include BCL2 and X-linked inhibitor of apoptosis protein (XIAP). 2550 miR-182 mmu-miR-182-5p,mmu-miR-182-3p MIMAT0000211,MIMAT0016995 miRNA Foxo3 apoptosis down Mus musculus lymphoblastic malignancies cells 22582938 10090 56484 1110048B16Rik|2010203A17Rik|C76856|FKHRL1|Fkhr2|Foxo3a MGI:1890081|Ensembl:ENSMUSG00000048756|Vega:OTTMUSG00000020929 10 10 B2|10 22.79 cM forkhead box O3 protein-coding forkhead box O3 Previous studies have suggested that microRNA-182 (miR-182) functions as an oncogene and plays a role in tumorigenesis, through regulation of FOXO3A. FOXO3A has been implicated in tumor suppression and GC-induced apoptosis, suggesting that FOXO3A has potential as a therapeutic target. 2551 miR-18a mmu-miR-18a-5p,mmu-miR-18a-3p MIMAT0000528,MIMAT0004626 miRNA Bcl2l11 apoptosis down Mus musculus CD4+ T cells 18327259 10090 12125 1500006F24Rik|Bim|Bod|bcl2-L-11 MGI:1197519|Ensembl:ENSMUSG00000027381|Vega:OTTMUSG00000015356 2 2|2 F3-G1 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) Bcl2 interacting mediator The miR-17-92 miRNA suppressed expression of the tumor suppressor PTEN and the proapoptotic protein Bim. 2552 miR-18a mmu-miR-18a-5p,mmu-miR-18a-3p MIMAT0000528,MIMAT0004626 miRNA Pten apoptosis down Mus musculus CD4+ T cells 18327259 10090 19211 2310035O07Rik|A130070J02Rik|AI463227|B430203M17Rik|MMAC1|TEP1 MGI:109583|Ensembl:ENSMUSG00000013663|Vega:OTTMUSG00000021203 19 19 C1|19 28.14 cM phosphatase and tensin homolog protein-coding phosphatase and tensin homolog Bcl2 interacting mediator The miR-17-92 miRNA suppressed expression of the tumor suppressor PTEN and the proapoptotic protein Bim. 2553 miR-19 mmu-miR-19a-5p,mmu-miR-19a-3p MIMAT0004660,MIMAT0000651 miRNA Bcl2l11 apoptosis down Mus musculus lymphocytes 20190740 10090 12125 1500006F24Rik|Bim|Bod|bcl2-L-11 MGI:1197519|Ensembl:ENSMUSG00000027381|Vega:OTTMUSG00000015356 2 2|2 F3-G1 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) Bcl2 interacting mediator To identify the miR-19 targets responsible for its oncogenic action, we conducted a large-scale short hairpin RNA screen for genes whose knockdown can phenocopy miR-19. Strikingly, the results of this screen were enriched for miR-19 target genes, and include Bim (Bcl2L11), AMP-activated kinase (Prkaa1) and the phosphatases Pten and PP2A (Ppp2r5e). 2554 miR-19 mmu-miR-19a-5p,mmu-miR-19a-3p MIMAT0004660,MIMAT0000651 miRNA Ppp2r5e apoptosis down Mus musculus lymphocytes 20190740 10090 26932 4633401M22Rik|AI449017|B56beta MGI:1349473|Ensembl:ENSMUSG00000021051 12 12 D1|12 protein phosphatase 2, regulatory subunit B', epsilon protein-coding protein phosphatase 2, regulatory subunit B', epsilon PP2A B subunit isoform B- To identify the miR-19 targets responsible for its oncogenic action, we conducted a large-scale short hairpin RNA screen for genes whose knockdown can phenocopy miR-19. Strikingly, the results of this screen were enriched for miR-19 target genes, and include Bim (Bcl2L11), AMP-activated kinase (Prkaa1) and the phosphatases Pten and PP2A (Ppp2r5e). 2555 miR-19 mmu-miR-19a-5p,mmu-miR-19a-3p MIMAT0004660,MIMAT0000651 miRNA Prkaa1 apoptosis down Mus musculus lymphocytes 20190740 10090 105787 AI194361|AI450832|AL024255|AMPKalpha1|C130083N04Rik MGI:2145955|Ensembl:ENSMUSG00000050697 15 15 A1|15 protein kinase, AMP-activated, alpha 1 catalytic subunit protein-coding protein kinase, AMP-activated, alpha 1 catalytic subunit 5-AMP-activated protein k To identify the miR-19 targets responsible for its oncogenic action, we conducted a large-scale short hairpin RNA screen for genes whose knockdown can phenocopy miR-19. Strikingly, the results of this screen were enriched for miR-19 target genes, and include Bim (Bcl2L11), AMP-activated kinase (Prkaa1) and the phosphatases Pten and PP2A (Ppp2r5e). 2556 miR-19 mmu-miR-19a-5p,mmu-miR-19a-3p MIMAT0004660,MIMAT0000651 miRNA Pten apoptosis down Mus musculus lymphocytes 20190740 10090 19211 2310035O07Rik|A130070J02Rik|AI463227|B430203M17Rik|MMAC1|TEP1 MGI:109583|Ensembl:ENSMUSG00000013663|Vega:OTTMUSG00000021203 19 19 C1|19 28.14 cM phosphatase and tensin homolog protein-coding phosphatase and tensin homolog mutated in multiple advan To identify the miR-19 targets responsible for its oncogenic action, we conducted a large-scale short hairpin RNA screen for genes whose knockdown can phenocopy miR-19. Strikingly, the results of this screen were enriched for miR-19 target genes, and include Bim (Bcl2L11), AMP-activated kinase (Prkaa1) and the phosphatases Pten and PP2A (Ppp2r5e). 2557 miR-193a-3p mmu-miR-193a-3p MIMAT0000223 miRNA Erbb4 apoptosis down Mus musculus lung cancer cell 25391651 10090 13869 Her4|c-erbB-4 MGI:104771|Ensembl:ENSMUSG00000062209|Vega:OTTMUSG00000025138 1 1 C3|1 33.8 cM v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) protein-coding v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) Furthermore, the biological consequences of the targeting of ERBB4 by miR-193a-3p were examined in vitro via cell proliferation, invasion, and apoptosis assays and in vivo using a mouse xenograft tumor model. We demonstrated that the repression of ERBB4 by miR-193a-3p suppressed proliferation and invasion and promoted apoptosis in lung cancer cells and that miR-193a-3p exerted an anti-tumor effect by negatively regulating ERBB4 in xenograft mice. 2558 miR-195 mmu-miR-195-5p,mmu-miR-195-3p MIMAT0000225,MIMAT0017000 miRNA Bcl2 apoptosis down Mus musculus cultured neonatal cardiomyocytes 21622680 10090 12043 AW986256|Bcl-2|C430015F12Rik|D630044D05Rik|D830018M01Rik MGI:88138|Ensembl:ENSMUSG00000057329|Vega:OTTMUSG00000022128 1 1 E2.1|1 49.76 cM B cell leukemia/lymphoma 2 protein-coding B cell leukemia/lymphoma 2 B-cell leukemia/lymphoma The effect of miR-195 on apoptosis is mediated through down-regulation of Sirt1 and Bcl-2 and ROS production. 2559 miR-195 mmu-miR-195-5p,mmu-miR-195-3p MIMAT0000225,MIMAT0017000 miRNA Bcl2 apoptosis down Mus musculus podocytes 22123611 10090 12043 AW986256|Bcl-2|C430015F12Rik|D630044D05Rik|D830018M01Rik MGI:88138|Ensembl:ENSMUSG00000057329|Vega:OTTMUSG00000022128 1 1 E2.1|1 49.76 cM B cell leukemia/lymphoma 2 protein-coding B cell leukemia/lymphoma 2 B-cell leukemia/lymphoma MiR-195 promotes apoptosis of podocytes under high-glucose conditions via enhanced caspase cascades for BCL2 insufficiency. 2560 miR-195 mmu-miR-195-5p,mmu-miR-195-3p MIMAT0000225,MIMAT0017000 miRNA Sirt1 apoptosis down Mus musculus cultured neonatal cardiomyocytes 21622680 10090 93759 AA673258|SIR2L1|Sir2|Sir2a|Sir2alpha MGI:2135607|Ensembl:ENSMUSG00000020063|Vega:OTTMUSG00000030914 10 10 B4|10 sirtuin 1 protein-coding sirtuin 1 NAD-dependent deacetylase The effect of miR-195 on apoptosis is mediated through down-regulation of Sirt1 and Bcl-2 and ROS production. 2561 miR-195 mmu-miR-195a-5p,mmu-miR-195a-3p MIMAT0000225,MIMAT0017000 miRNA apoptosis Mus musculus mesangial cells 21983986 10090 Moreover, the microRNA-195 inhibitor protected mesangial cells from apoptosis and promoted the cellular proliferation in vitro. 2562 miR-19a mmu-miR-19a-5p,mmu-miR-19a-3p MIMAT0004660,MIMAT0000651 miRNA Bcl2l11 apoptosis down Mus musculus CD4+ T cells 18327259 10090 12125 1500006F24Rik|Bim|Bod|bcl2-L-11 MGI:1197519|Ensembl:ENSMUSG00000027381|Vega:OTTMUSG00000015356 2 2|2 F3-G1 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) Bcl2 interacting mediator The miR-17-92 miRNA suppressed expression of the tumor suppressor PTEN and the proapoptotic protein Bim. 2563 miR-19a mmu-miR-19a-5p,mmu-miR-19a-3p MIMAT0004660,MIMAT0000651 miRNA Pten apoptosis down Mus musculus CD4+ T cells 18327259 10090 19211 2310035O07Rik|A130070J02Rik|AI463227|B430203M17Rik|MMAC1|TEP1 MGI:109583|Ensembl:ENSMUSG00000013663|Vega:OTTMUSG00000021203 19 19 C1|19 28.14 cM phosphatase and tensin homolog protein-coding phosphatase and tensin homolog mutated in multiple advan The miR-17-92 miRNA suppressed expression of the tumor suppressor PTEN and the proapoptotic protein Bim. 2564 miR-19b mmu-miR-19b-3p,mmu-miR-19b-1-5p,mmu-miR-19b-2-5p MIMAT0000513,MIMAT0017010,MIMAT0017065 miRNA Bcl2l11 apoptosis down Mus musculus CD4+ T cells 18327259 10090 12125 1500006F24Rik|Bim|Bod|bcl2-L-11 MGI:1197519|Ensembl:ENSMUSG00000027381|Vega:OTTMUSG00000015356 2 2|2 F3-G1 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) Bcl2 interacting mediator The miR-17-92 miRNA suppressed expression of the tumor suppressor PTEN and the proapoptotic protein Bim. 2565 miR-19b mmu-miR-19b-3p,mmu-miR-19b-1-5p,mmu-miR-19b-2-5p MIMAT0000513,MIMAT0017010,MIMAT0017065 miRNA Pten apoptosis down Mus musculus CD4+ T cells 18327259 10090 19211 2310035O07Rik|A130070J02Rik|AI463227|B430203M17Rik|MMAC1|TEP1 MGI:109583|Ensembl:ENSMUSG00000013663|Vega:OTTMUSG00000021203 19 19 C1|19 28.14 cM phosphatase and tensin homolog protein-coding phosphatase and tensin homolog Bcl2 interacting mediator The miR-17-92 miRNA suppressed expression of the tumor suppressor PTEN and the proapoptotic protein Bim. 2566 miR-200 mmu-miR-200a-3p ,mmu-miR-200a-5p,mmu-miR-200b-5p,mmu-miR-200b-3p,mmu-miR-200c-3p ,mmu-miR-200c-5p MIMAT0000519,MIMAT0004619,MIMAT0004545,MIMAT0000233,MIMAT0000657,MIMAT0004663 miRNA Zeb1 apoptosis down Mus musculus osteosarcoma?cell 24815002 10090 21417 3110032K11Rik|AREB6|BZP|MEB1|Nil2|TCF-8|Tcf18|Tcf8|Tw|ZEB|Zfhep|Zfhx1a|Zfx1a|Zfx1ha|[delta]EF1 MGI:1344313|Ensembl:ENSMUSG00000024238|Vega:OTTMUSG00000030924 18 18 A1|18 4.42 cM zinc finger E-box binding homeobox 1 protein-coding zinc finger E-box binding homeobox 1 Here, we showed that busulfan dose-dependently reduced the cell viability and proliferation, and induced cell apoptosis, senescence, and reactive oxygen species levels in two osteosarcoma cell lines. Moreover, a series of loss-of-function and gain-of-function experiments further indicated that busulfan may have its anti-osteosarcoma effect by upregulating the microRNA-200 (miR-200) family which subsequently downregulated its target genes ZEB1 and ZEB2. 2567 miR-200 mmu-miR-200a-3p ,mmu-miR-200a-5p,mmu-miR-200b-5p,mmu-miR-200b-3p,mmu-miR-200c-3p ,mmu-miR-200c-5p MIMAT0000519,MIMAT0004619,MIMAT0004545,MIMAT0000233,MIMAT0000657,MIMAT0004663 miRNA Zeb2 apoptosis down Mus musculus osteosarcoma?cell 24815002 10090 24136 9130203F04Rik|D130016B08Rik|SIP1|Zfhx1b|Zfx1b|Zfxh1b MGI:1344407|Ensembl:ENSMUSG00000026872|Vega:OTTMUSG00000012355 2 2|2 C1 zinc finger E-box binding homeobox 2 protein-coding zinc finger E-box binding homeobox 2 Here, we showed that busulfan dose-dependently reduced the cell viability and proliferation, and induced cell apoptosis, senescence, and reactive oxygen species levels in two osteosarcoma cell lines. Moreover, a series of loss-of-function and gain-of-function experiments further indicated that busulfan may have its anti-osteosarcoma effect by upregulating the microRNA-200 (miR-200) family which subsequently downregulated its target genes ZEB1 and ZEB2. 2568 miR-200a mmu-miR-200a-3p ,mmu-miR-200a-5p MIMAT0000519,MIMAT0004619 miRNA Pten apoptosis down Mus musculus uterus cells 23690337 10090 19211 2310035O07Rik|A130070J02Rik|AI463227|B430203M17Rik|MMAC1|TEP1 MGI:109583|Ensembl:ENSMUSG00000013663|Vega:OTTMUSG00000021203 19 19 C1|19 28.14 cM phosphatase and tensin homolog protein-coding phosphatase and tensin homolog Mmu-microRNA-200a Overexpression Leads to Implantation Defect by Targeting Phosphatase and Tensin Homolog in Mouse Uterus.In vitro gain and loss of function experiments confirm that PTEN, a critical gene for cell proliferation and apoptosis, is the target gene of mmu-miR-200a. 2569 miR-200c mmu-miR-200c-3p ,mmu-miR-200c-5p MIMAT0000657,MIMAT0004663 miRNA Bmi1 apoptosis down Mus musculus lymphoma 24375660 10090 12151 AW546694|Bmi-1|Pcgf4 MGI:88174|Ensembl:ENSMUSG00000026739|Vega:OTTMUSG00000011429 2 2 A3|2 12.9 cM Bmi1 polycomb ring finger oncogene protein-coding Bmi1 polycomb ring finger oncogene Forced over-expression of miR-200c decreased the level of BMI1 protein and moreover, over-expression of BMI1 rescued the biological effects of miR-200c, indicating BMI1 is a direct mediator of miR-200c functions. 2570 miR-200c mmu-miR-200c-5p,mmu-miR-200c-3p MIMAT0000657,MIMAT0004663 miRNA Fas apoptosis down Mus musculus BV-2 cell 25448187 10090 14102 AI196731|APO1|APT1|CD95|TNFR6|Tnfrsf6|lpr MGI:95484|Ensembl:ENSMUSG00000024778 19 19 C1|19 29.48 cM Fas (TNF receptor superfamily member 6) protein-coding Fas (TNF receptor superfamily member 6) The upregulation of miR-200c reduced cell viability and induced BV-2 cell apoptosis. MiR-200c negatively regulated the expression of FAP-1, thereby inducing FAS signaling-induced apoptosis. 2571 miR-203 mmu-miR-203-3p,mmu-miR-203-5p MIMAT0000236,MIMAT0004547 miRNA Asap1 apoptosis down Mus musculus laryngeal squamous cell 24682952 10090 13196 AV239055|DEF-1|Ddef1|PAP|mKIAA1249|s19 MGI:1342335|Ensembl:ENSMUSG00000022377|Vega:OTTMUSG00000042047 15 15|15 D3 ArfGAP with SH3 domain, ankyrin repeat and PH domain1 protein-coding ArfGAP with SH3 domain, ankyrin repeat and PH domain1 Transfection with miR-203 inhibited proliferation, reduced invasion, induced apoptosis and caused G1 phase cell cycle arrest of Hep-2 cells in vitro, suggesting that miR-203 functioned as a tumour suppressor. We have also tested that over-expression of miR-203 may both suppress the growth of xenograft tumours in mice and downregulate the expressions of ASAP1 in vivo. 2572 miR-203 mmu-miR-203-3p,mmu-miR-203-5p MIMAT0000236,MIMAT0004547 miRNA Birc5 apoptosis down Mus musculus pancreatic cancer cell line cells 23732815 10090 11799 AAC-11|Api4|TIAP|survivin40 MGI:1203517|Ensembl:ENSMUSG00000017716|Vega:OTTMUSG00000003737 11 11|11 E2 baculoviral IAP repeat-containing 5 protein-coding baculoviral IAP repeat-containing 5 miR-203 regulates the proliferation, apoptosis and cell cycle progression of pancreatic cancer cells by targeting Survivin.Female BALB/cA?nu nude mice were used to validate the role of miR?203 in vivo.Transfection with miR?203 mimic inhibited CFPAC?1 cell proliferation and induced apoptosis and G1 phase cell cycle arrest, similar to knockdown of Survivin. The protein levels of Survivin were found to negatively correlate with miR?203 levels in four PC cell lines 2573 miR-203 mmu-miR-203-5p,mmu-miR-203-3p MIMAT0004547,MIMAT0000236 miRNA apoptosis Mus musculus nonylphenol -treated Sertoli cells 21914226 10090 Comprehensiveanalysis of predicted target genes for miRNAs showed that the expression of genes with roles in cell proliferation, the cell cycle, and cell death were regulated by miRNA in NP-treated TM4 cells. 2574 miR-204 mmu-miR-204-5p,mmu-miR-204-3p MIMAT0000237,MIMAT0017002 miRNA Sirt1 apoptosis up Mus musculus microglia 25725784 10090 93759 AA673258|SIR2L1|Sir2|Sir2a|Sir2alpha MGI:2135607|Ensembl:ENSMUSG00000020063|Vega:OTTMUSG00000030914 10 10 B4|10 sirtuin 1 protein-coding sirtuin 1 Mice microglia cell lines were transfected with miR-204 mimics and inhibitors or treated with resveratrol, and the effects on cell growth, proliferation, and apoptosis of cells were assessed. LPS induced inflammation and activation of mice microglia. Through overexpression of SIRT1, resveratrol, and inhibitor of miR-204 inhibited inflammation process, proliferation of mice microglia cells and promoted its apoptosis. We identified if resveratrol and miR-204 could repress inflammation process and proliferation of mice microglia cell through promoting the expression of SIRT1. 2575 miR-206 mmu-miR-206-5p,mmu-miR-206-3p MIMAT0017004,MIMAT0000239 miRNA Vegfa apoptosis down Mus musculus laryngeal suamous cell carcinoma cells 22110210 10090 22339 Vegf|Vpf MGI:103178|Ensembl:ENSMUSG00000023951|Vega:OTTMUSG00000016285 17 17 C|17 22.79 cM vascular endothelial growth factor A protein-coding vascular endothelial growth factor A vascular permeability fa Cell proliferation, migration, invasion and tumorigenesis in the LSCC cells were significantly inhibited and apoptotic cells were also increased after miR-206 tansfection. Furthermore, miR-206 transfection down-regulated the expression of vascular endothelial growth factor (VEGF) in the LSCC cells. The loss of miR-206 may play an important role in the progress of LSCC and miR-206 may function as a novel tumor suppressed miRNA. 2576 miR-207 mmu-miR-207 MIMAT0000240 miRNA Akt3 apoptosis down Mus musculus cochlea hair cell 25275594 10090 23797 AI851531|D930002M15Rik|Nmf350 MGI:1345147|Ensembl:ENSMUSG00000019699|Vega:OTTMUSG00000020798 1 1|1 H4-H6 thymoma viral proto-oncogene 3 protein-coding thymoma viral proto-oncogene 3 MicroRNA-207 enhances radiation-induced apoptosis by directly targeting Akt3 in cochlea hair cells.MicroRNA-207 enhances radiation-induced apoptosis by directly targeting Akt3 in cochlea hair cells. Furthermore, Akt3 was confirmed to be a direct target of miR-207. Downregulation of Akt3 mimics the effects of miR-207. MiR-207 enhances IR-induced apoptosis by directly targeting Akt3 and anti-miR-207 may have a potential role in protecting cochlea hair cells from IR. 2577 miR-20a mmu-miR-20a-5p,mmu-miR-20a-3p MIMAT0000529,MIMAT0004627 miRNA Bcl2l11 apoptosis down Mus musculus CD4+ T cells 18327259 10090 12125 1500006F24Rik|Bim|Bod|bcl2-L-11 MGI:1197519|Ensembl:ENSMUSG00000027381|Vega:OTTMUSG00000015356 2 2|2 F3-G1 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) Bcl2 interacting mediator The miR-17-92 miRNA suppressed expression of the tumor suppressor PTEN and the proapoptotic protein Bim. 2578 miR-20a mmu-miR-20a-5p,mmu-miR-20a-3p MIMAT0000529,MIMAT0004627 miRNA Pten apoptosis down Mus musculus CD4+ T cells 18327259 10090 19211 2310035O07Rik|A130070J02Rik|AI463227|B430203M17Rik|MMAC1|TEP1 MGI:109583|Ensembl:ENSMUSG00000013663|Vega:OTTMUSG00000021203 19 19 C1|19 28.14 cM phosphatase and tensin homolog protein-coding phosphatase and tensin homolog mutated in multiple advan The miR-17-92 miRNA suppressed expression of the tumor suppressor PTEN and the proapoptotic protein Bim. 2579 miR-20a mmu-miR-20a-5p,mmu-miR-20a-3p MIMAT0000529,MIMAT0004627 miRNA Trp53inp1 apoptosis down Mus musculus human gastric cancer cells 23333058 10090 60599 2700057G22Rik|SIP|SIP18|SIP27|Stinp|Teap MGI:1926609|Ensembl:ENSMUSG00000028211|Vega:OTTMUSG00000004505 4 4|4 A1-A2 transformation related protein 53 inducible nuclear protein 1 protein-coding transformation related protein 53 inducible nuclear protein 1 Overexpression of miR-17-5p/20a promoted gastric cancer cell cycle progression and inhibited cell apoptosis, whereas knockdown of miR-17-5p/20a resulted in cell cycle arrest and increased apoptosis. p21 and tumour protein p53-induced nuclear protein 1 (TP53INP1) were validated as the targets of miR-17-5p/20a. 2580 miR-20a mmu-miR-20a-5p,mmu-miR-20a-3p MIMAT0000529,MIMAT0004627 miRNA apoptosis Mus musculus nonylphenol -treated Sertoli cells 21914226 10090 Comprehensiveanalysis of predicted target genes for miRNAs showed that the expression of genes with roles in cell proliferation, the cell cycle, and cell death were regulated by miRNA in NP-treated TM4 cells. 2581 miR-21 mmu-miR-21-5p,mmu-miR-21-3p MIMAT0000530,MIMAT0004628 miRNA Pdcd4 apoptosis down Mus musculus epidermal JB6 cells 18372920 10090 18569 D19Ucla1|Ma3|Tis MGI:107490|Ensembl:ENSMUSG00000024975 19 19 D2|19 48.73 cM programmed cell death 4 protein-coding programmed cell death 4 programmed cell death pro Overexpression of miR-21 in MCF-7 human breast cancer cells and mouse epidermal JB6 cells promoted soft agar colony formation by downregulating Pdcd4 protein levels 2582 miR-21 mmu-miR-21-5p,mmu-miR-21-3p MIMAT0000530,MIMAT0004628 miRNA Pdcd4 apoptosis down Mus musculus osteoclasts 21273303 10090 18569 D19Ucla1|Ma3|Tis MGI:107490|Ensembl:ENSMUSG00000024975 19 19 D2|19 48.73 cM programmed cell death 4 protein-coding programmed cell death 4 programmed cell death pro MiR-21 was identified as an miR expression signature of RANKL-induced osteoclastogenesis that down-regulates programmed cell death 4 (PDCD4) protein levels. 2583 miR-21 mmu-miR-21-5p,mmu-miR-21-3p MIMAT0000530,MIMAT0004628 miRNA Pdcd4 apoptosis down Mus musculus T lymphocytes 21469086 10090 18569 D19Ucla1|Ma3|Tis MGI:107490|Ensembl:ENSMUSG00000024975 19 19 D2|19 48.73 cM programmed cell death 4 protein-coding programmed cell death 4 programmed cell death pro MiR-21 targets directly the expression of programmed cell death 4 (PDCD4) and overexpression of miR-21 in cells harboring the 3'UTR of PDCD4 resulted in reduced transcription and PDCD4 protein expression 2584 miR-21 mmu-miR-21-5p,mmu-miR-21-3p MIMAT0000530,MIMAT0004628 miRNA Pdcd4 apoptosis down Mus musculus pancreatic ÉÇ cells 21730150 10090 18569 D19Ucla1|Ma3|Tis MGI:107490|Ensembl:ENSMUSG00000024975 19 19 D2|19 48.73 cM programmed cell death 4 protein-coding programmed cell death 4 programmed cell death pro In pancreatic ¦Â cells, c-Rel and p65 of the NF-¦ÊB family activated the mir21 gene promoter and increased miR-21 RNA levels; miR-21 in turn decreased the level of PDCD4, which is able to induce cell death through the Bax family of apoptotic proteins. 2585 miR-21 mmu-miR-21-5p,mmu-miR-21-3p MIMAT0000530,MIMAT0004628 miRNA Pdcd4 apoptosis down Mus musculus kidney cells 22785173 10090 18569 D19Ucla1|Ma3|Tis MGI:107490|Ensembl:ENSMUSG00000024975 19 19 D2|19 48.73 cM programmed cell death 4 protein-coding programmed cell death 4 Knockdown of miR-21 resulted in significant upregulation of programmed cell death protein 4, a proapoptotic target gene of miR-21, and substantially increased tubular cell apoptosis. 2586 miR-21 mmu-miR-21a-5p,mmu-miR-21a-3p,mmu-miR-21b,mmu-miR-21c MIMAT0000530,MIMAT0004628,MIMAT0025121,MIMAT002514 miRNA Pdcd4 apoptosis down Mus musculus cholangitis 23395552 10090 18569 D19Ucla1|Ma3|Tis MGI:107490|Ensembl:ENSMUSG00000024975 19 19 D2|19 48.73 cM programmed cell death 4 protein-coding programmed cell death 4 Previous studies indicate that miR-21 increases the synthesis of IFN-¦Ã and IL-17A by T cells and suppresses apoptosis via programmed cell death protein 4 (PDCD4) 2587 miR-21 mmu-miR-21-5p,mmu-miR-21-3p MIMAT0000530,MIMAT0004628 miRNA Pdcd4 apoptosis down Mus musculus renal cells 23681145 10090 18569 D19Ucla1|Ma3|Tis MGI:107490|Ensembl:ENSMUSG00000024975 19 19 D2|19 48.73 cM programmed cell death 4 protein-coding programmed cell death 4 Knockdown of miR-21 induced significant up-regulation of programmed cell death protein 4 and phosphatase and tensin homolog deleted on chromosome 10, two proapoptotic target effectors of miR-21, and resulted in significant down-regulation of phosphorylated protein kinase B and increased tubular cell apoptosis. 2588 miR-21 mmu-miR-21-5p,mmu-miR-21-3p MIMAT0000530,MIMAT0004628 miRNA Pten apoptosis down Mus musculus renal cells 23681145 10090 19211 2310035O07Rik|A130070J02Rik|AI463227|B430203M17Rik|MMAC1|TEP1 MGI:109583|Ensembl:ENSMUSG00000013663|Vega:OTTMUSG00000021203 19 19 C1|19 28.14 cM phosphatase and tensin homolog protein-coding phosphatase and tensin homolog Knockdown of miR-21 induced significant up-regulation of programmed cell death protein 4 and phosphatase and tensin homolog deleted on chromosome 10, two proapoptotic target effectors of miR-21, and resulted in significant down-regulation of phosphorylated protein kinase B and increased tubular cell apoptosis. 2589 miR-21 mmu-miR-21-5p,mmu-miR-21-3p MIMAT0000530,MIMAT0004628 miRNA apoptosis down Mus musculus spermatogonial stem cells 21768389 10090 Transient inhibition of miR-21 in SSC-enriched germ cell cultures increased the number of germ cells undergoing apoptosis and significantly reduced the number of donor-derived colonies of spermatogenesis formed from transplanted treated cells in recipient mouse testes, indicating that miR-21 is important in maintaining the SSC population. 2590 miR-210 mmu-miR-210-3p,mmu-miR-210-5p MIMAT0000658,MIMAT0017052 miRNA Aifm3 apoptosis Mus musculus cardiomyocytic cells 21841015 10090 72168 2810401C16Rik|AI840249|Aifl MGI:1919418|Ensembl:ENSMUSG00000022763|Vega:OTTMUSG00000025661 16 16 A3|16 apoptosis-inducing factor, mitochondrion-associated 3 protein-coding apoptosis-inducing factor, mitochondrion-associated 3 To determine a mechanism for the cytoprotective effects of miR-210, we focused on the predicted target, apoptosis-inducing factor, mitochondrion associated 3 (AIFM3), known to induce cell death. 2591 miR-214 mmu-miR-214-5p,mmu-miR-214-3p MIMAT0004664,MIMAT0000661 miRNA Ltf apoptosis down Mus musculus mammary epithelial cells 20610637 10090 17002 Csp82|Lf|MMS10R|Ms10r MGI:96837|Ensembl:ENSMUSG00000032496 9 9 F|9 60.79 cM lactotransferrin protein-coding lactotransferrin N lobe; lactoferrin; mini Furthermore, in MCF7 cells, overexpression of miR-214 markedly decreased lactoferrin expression (P lt 0.05), and inhibition of endogenous miR-214 expression increased lactoferrin expression and cellular apoptotic activities (P lt 0.05) 2592 miR-214 mmu-miR-214-3p,mmu-miR-214-5p MIMAT0004664,MIMAT0000661 miRNA Nras apoptosis down Mus musculus embryonic fibroblast 24811402 10090 18176 AV095280|N-ras MGI:97376|Ensembl:ENSMUSG00000027852|Vega:OTTMUSG00000021269 3 3 F2.2|3 45.25 cM neuroblastoma ras oncogene protein-coding neuroblastoma ras oncogene When re-introduced into RD cells, a line of human embryonal RMS cells, miR-214 showed inhibition of tumor cell growth, induction of myogenic differentiation and apoptosis, as well as suppression of colony formation and xenograft tumorigenesis. We show that in the absence of miR-214, expression of proto-oncogene N-ras is markedly elevated in miR-214(-/-) MEFs, and manipulations of miR-214 levels using microRNA mimics or inhibitor in RD cells reciprocally altered N-ras expression. We further demonstrate that forced expression of N-ras from a cDNA that lacks its 3'-untranslated region neutralized the pro-myogenic and anti-proliferative activities of miR-214. Finally, we show that N-ras is a conserved target of miR-214 in its suppression of xenograft tumor growth, and N-ras expression is up-regulated in xenograft tumor models as well as actual human RMS tissue sections. Taken together, these data indicate that miR-214 is a bona fide suppressor of human RMS tumorigensis. 2593 miR-218 mmu-miR-218-5p,mmu-miR-218-1-3p,mmu-miR-218-2-3p MIMAT0000663,MIMAT0004665,MIMAT0005444 miRNA Akt1 apoptosis Mus musculus esophageal squamous cell 25482044 10090 11651 Akt|PKB|PKB/Akt|PKBalpha|Rac MGI:87986|Ensembl:ENSMUSG00000001729|Vega:OTTMUSG00000020941 12 12 F1|12 61.2 cM thymoma viral proto-oncogene 1 protein-coding thymoma viral proto-oncogene 1 We also found that enforced expression of miR-218 significantly decreased cell proliferation, colony formation, migration and invasion, induced cell apoptosis and arrested the cell cycle in the G0/G1 phase, as well as suppressed tumor growth in a nude mouse model. In addition, our results showed that miR-218 mimics increased the sensitivity to the antitumor effect of CDDP in the human Eca109 cells. Importantly, this study also showed that miR-218 regulated the expression of phosphorylated PI3K, AKT and mTOR, which may contribute to suppressed tumor growth of ESCC and enhanced sensitivity of ESCC cells. These findings suggest that miR-218 is a potential therapeutic agent for the treatment of ESCC. 2594 miR-218 mmu-miR-218-5p,mmu-miR-218-1-3p,mmu-miR-218-2-3p MIMAT0000663,MIMAT0004665,MIMAT0005444 miRNA Bmi1 apoptosis down Mus musculus HepG2/SMMC-7721 cell 25110121 10090 12151 AW546694|Bmi-1|Pcgf4 MGI:88174|Ensembl:ENSMUSG00000026739|Vega:OTTMUSG00000011429 2 2 A3|2 12.9 cM Bmi1 polycomb ring finger oncogene protein-coding Bmi1 polycomb ring finger oncogene In tumor bearing mice, miR-218 slowed down tumor growth by inducing apoptosis and growth arrest. Restoring miR-218 expression resulted in downregulation of B lymphoma Mo-MLV insertion region?1 homolog (BMI-1) mRNA and protein level in HepG2 and SMMC-7721 cells. I 2595 miR-218 mmu-miR-218-5p,mmu-miR-218-1-3p,mmu-miR-218-2-3p MIMAT0000663,MIMAT0004665,MIMAT0005444 miRNA Mtor apoptosis Mus musculus esophageal squamous cell 25482044 10090 56717 2610315D21Rik|AI327068|FRAP|FRAP2|Frap1|RAFT1|RAPT1|flat MGI:1928394|Ensembl:ENSMUSG00000028991|Vega:OTTMUSG00000010950 4 4 E1|4 78.76 cM mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) We also found that enforced expression of miR-218 significantly decreased cell proliferation, colony formation, migration and invasion, induced cell apoptosis and arrested the cell cycle in the G0/G1 phase, as well as suppressed tumor growth in a nude mouse model. In addition, our results showed that miR-218 mimics increased the sensitivity to the antitumor effect of CDDP in the human Eca109 cells. Importantly, this study also showed that miR-218 regulated the expression of phosphorylated PI3K, AKT and mTOR, which may contribute to suppressed tumor growth of ESCC and enhanced sensitivity of ESCC cells. These findings suggest that miR-218 is a potential therapeutic agent for the treatment of ESCC. 2596 miR-218 mmu-miR-218-5p,mmu-miR-218-1-3p,mmu-miR-218-2-3p MIMAT0000663,MIMAT0004665,MIMAT0005444 miRNA Pik3r1 apoptosis Mus musculus esophageal squamous cell 25482044 10090 18708 PI3K|p50alpha|p55alpha|p85alpha MGI:97583|Ensembl:ENSMUSG00000041417 13 13 D1|13 53.92 cM phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) protein-coding phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) We also found that enforced expression of miR-218 significantly decreased cell proliferation, colony formation, migration and invasion, induced cell apoptosis and arrested the cell cycle in the G0/G1 phase, as well as suppressed tumor growth in a nude mouse model. In addition, our results showed that miR-218 mimics increased the sensitivity to the antitumor effect of CDDP in the human Eca109 cells. Importantly, this study also showed that miR-218 regulated the expression of phosphorylated PI3K, AKT and mTOR, which may contribute to suppressed tumor growth of ESCC and enhanced sensitivity of ESCC cells. These findings suggest that miR-218 is a potential therapeutic agent for the treatment of ESCC. 2597 miR-221 mmu-miR-221-3p,mmu-miR-221-5p MIMAT0000669,MIMAT0017060 miRNA Arnt apoptosis down Mus musculus hepatocellular carcinoma cells 22821679 10090 11863 D3Ertd557e|Drnt|ESTM42|Hif1b|W08714|bHLHe2|mKIAA4051 MGI:88071|Ensembl:ENSMUSG00000015522|Vega:OTTMUSG00000016472 3 3 F2.1|3 40.74 cM aryl hydrocarbon receptor nuclear translocator protein-coding aryl hydrocarbon receptor nuclear translocator miR-221, which is frequently up-regulated in HCCs, delays fulminant liver failure in mice by inhibiting apoptosis, indicating a pleiotropic role of miR-221 in hepatocytes. we identify Aryl hydrocarbon nuclear translocator (Arnt) messenger RNA (mRNA) as a novel target of miR-221, which contributes to the pro-proliferative activity of miR-221 2598 miR-23a mmu-miR-23a-3p,mmu-miR-23a-5p MIMAT0000532,MIMAT0017019 miRNA Fas apoptosis down Mus musculus osteoblastic cells 23804233 10090 14102 AI196731|APO1|APT1|CD95|TNFR6|Tnfrsf6|lpr MGI:95484|Ensembl:ENSMUSG00000024778 19 19 C1|19 29.48 cM Fas (TNF receptor superfamily member 6) protein-coding Fas (TNF receptor superfamily member 6) MicroRNA-23a modulates tumor necrosis factor-alpha-induced osteoblasts apoptosis by directly targeting Fas.Mechanistic studies showed that microRNA-23a inhibits Fas expression through a microRNA-23a-binding site within the 3'- untranslational region of Fas. 2599 miR-24 mmu-miR-24-1-5p,mmu-miR-24-3p,mmu-miR-24-2-5p MIMAT0000218,MIMAT0000219,MIMAT0005440 miRNA Bcl2l11 apoptosis down Mus musculus cardiomyocyte cells 21383058 10090 12125 1500006F24Rik|Bim|Bod|bcl2-L-11 MGI:1197519|Ensembl:ENSMUSG00000027381|Vega:OTTMUSG00000015356 2 2|2 F3-G1 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) MiR-24 inhibits apoptosis and represses Bim in mouse cardiomyocytes. 2600 miR-24 mmu-miR-24-1-5p,mmu-miR-24-3p,mmu-miR-24-2-5p MIMAT0000218,MIMAT0000219,MIMAT0005440 miRNA Nos3 apoptosis down Mus musculus cardiomyocyte cells 23774796 10090 18127 2310065A03Rik|Nos-3|eNOS|ecNOS MGI:97362|Ensembl:ENSMUSG00000028978|Vega:OTTMUSG00000024082 5 5 A3|5 11.32 cM nitric oxide synthase 3, endothelial cell protein-coding nitric oxide synthase 3, endothelial cell we aimed at clarifying the effect of adenovirus-mediate intra-myocardial delivery of a decoy for miRNA-24 in a mouse MI model and to investigate the impact of miRNA-24 inhibition on angiogenesis and cardiovascular apoptosis. miRNA-24 inhibition enhanced ECs survival, proliferation and networking in capillary-like tubes and induced cardiomyocyte and fibroblast apoptosis. Finally, we identified eNOS as a novel direct target of miR-24 in human cultured ECs and in vivo. 2601 miR-24 mmu-miR-24-1-5p,mmu-miR-24-3p,mmu-miR-24-2-5p MIMAT0000218,MIMAT0000219,MIMAT0005440 miRNA Sod1 apoptosis up Mus musculus sertoli cells 20467044 10090 20655 B430204E11Rik|Cu/Zn-SOD|CuZnSOD|Ipo-1|Ipo1|SODC|Sod-1 MGI:98351|Ensembl:ENSMUSG00000022982 16 16 B5-C3|16 51.56 cM superoxide dismutase 1, soluble protein-coding superoxide dismutase 1, soluble Furthermore, through 3'UTR luciferase assays we identified one up-regulated protein, SOD-1, a Cu/Zn superoxide dismutase whose overexpression has been linked to enhanced cell death through apoptosis, as a likely direct target of three Sertoli cell-expressed miRNAs, miR-125a-3p, miR-872 and miR-24. 2602 miR-290 mmu-miR-290a-5p,mmu-miR-290a-3p,mmu-miR-290b-5p,mmu-miR-290b-3p MIMAT0000366,MIMAT0004572,MIMAT0029900,MIMAT002990 miRNA Arid4b apoptosis down Mus musculus breast cancer 23447578 10090 94246 BCAA|BRCAA1|RBBP1L1|Rbp1l1|SAP180 MGI:2137512|Ensembl:ENSMUSG00000039219|Vega:OTTMUSG00000018144 13 13 A1|13 5.29 cM AT rich interactive domain 4B (RBP1-like) protein-coding AT rich interactive domain 4B (RBP1-like) Computational analysis identified breast cancer progression gene Arid4b as a top target of miR-290-3p, which was confirmed by luciferase reporter assay. 2603 miR-294 mmu-miR-294-5p,mmu-miR-294-3p MIMAT0004574,MIMAT0000372 miRNA apoptosis down Mus musculus embryonic stem cell 25501598 10090 Suppression of epithelial-mesenchymal transition and apoptotic pathways by miR-294/302 family synergistically blocks let-7-induced silencing of self-renewal in embryonic stem cells. 2604 miR-29a mmu-miR-29a-3p,mmu-miR-29a-5p MIMAT0004631,MIMAT0000535 miRNA Hdac4 apoptosis down Mus musculus renal glomeruli 24578127 10090 208727 4932408F19Rik|AI047285 MGI:3036234|Ensembl:ENSMUSG00000026313 1 1 D|1 histone deacetylase 4 protein-coding histone deacetylase 4 Overexpression of miR-29a attenuated the promotion of HDAC4 signaling, nephrin ubiquitination, and urinary nephrin excretion associated with diabetes and restored nephrin acetylation. 2605 miR-29a mmu-miR-29a-3p,mmu-miR-29a-5p MIMAT0000535,MIMAT0004631 miRNA Mcl1 apoptosis down Mus musculus islet cells 22537941 10090 17210 AW556805|Mcl-1 MGI:101769|Ensembl:ENSMUSG00000038612 3 3 F2.1|3 40.74 cM myeloid cell leukemia sequence 1 protein-coding myeloid cell leukemia sequence 1 Overexpression of miR-29a/b/c also promoted apoptosis by decreasing the level of the antiapoptotic protein Mcl1. 2606 miR-29b mmu-miR-29b-3p,mmu-miR-29b-1-5p,mmu-miR-29b-2-5p MIMAT0000127,MIMAT0004523,MIMAT0017063 miRNA Mcl1 apoptosis down Mus musculus islet cells 22537941 10090 17210 AW556805|Mcl-1 MGI:101769|Ensembl:ENSMUSG00000038612 3 3 F2.1|3 40.74 cM myeloid cell leukemia sequence 1 protein-coding myeloid cell leukemia sequence 1 Overexpression of miR-29a/b/c also promoted apoptosis by decreasing the level of the antiapoptotic protein Mcl1. 2607 miR-29b mmu-miR-29b-3p,mmu-miR-29b-1-5p,mmu-miR-29b-2-5p MIMAT0000127,MIMAT0004523,MIMAT0017063 miRNA Mcl1 apoptosis down Mus musculus ¦Â-cell 25587719 10090 17210 AW556805|Mcl-1 MGI:101769|Ensembl:ENSMUSG00000038612 3 3 F2.1|3 40.74 cM myeloid cell leukemia sequence 1 protein-coding myeloid cell leukemia sequence 1 In non-obese diabetic mice, microRNA-29b downregulates the antiapoptotic protein Mcl-1, which leads to early ¦Â-cell death. 2608 miR-29c mmu-miR-29c-3p,mmu-miR-29c-5p MIMAT0000536,MIMAT0004632 miRNA Mcl1 apoptosis down Mus musculus islet cells 22537941 10090 17210 AW556805|Mcl-1 MGI:101769|Ensembl:ENSMUSG00000038612 3 3 F2.1|3 40.74 cM myeloid cell leukemia sequence 1 protein-coding myeloid cell leukemia sequence 1 Overexpression of miR-29a/b/c also promoted apoptosis by decreasing the level of the antiapoptotic protein Mcl1. 2609 miR-29c mmu-miR-29c-3p,mmu-miR-29c-5p MIMAT0000536,MIMAT0004632 miRNA Spry1 apoptosis down Mus musculus renal cell 21310958 10090 24063 sprouty1 MGI:1345139|Ensembl:ENSMUSG00000037211|Vega:OTTMUSG00000007497 3 3 B|3 sprouty homolog 1 (Drosophila) protein-coding sprouty homolog 1 (Drosophila) Conversely, knockdown of miR-29c prevented high glucose-induced cell apoptosis. We also identified Sprouty homolog 1 (Spry1) as a direct target of miR-29c with a nearly perfect complementarity between miR-29c and the 3'-untranslated region (UTR) of mouse Spry1. 2610 miR-30 mmu-miR-30a-5p,mmu-miR-30a-3p,mmu-miR-30b-5p,mmu-miR-30b-3p,mmu-miR-30c-5p,mmu-miR-30c-1-3p,mmu-miR-30c-2-3p,mmu-miR-30d-5p,mmu-miR-30d-3p,mmu-miR-30e-5p,mmu-miR-30e-3p MIMAT0000128,MIMAT0000129,MIMAT0000130,MIMAT0004524,MIMAT0000514,MIMAT0004616,MIMAT0005438,MIMAT0000515,MIMAT0017011,MIMAT0000248,MIMAT0000249 miRNA Tcf3 apoptosis down Mus musculus leukocyte cella 22342458 10090 21423 A1|AA408400|ALF2|AW209082|E12|E12/E47|E2A|E47|ME2|Pan1|Pan2|TCF-3|Tcfe2a|VDIR|bHLHb21 MGI:98510|Ensembl:ENSMUSG00000020167|Vega:OTTMUSG00000019126 10 10 C1|10 39.72 cM transcription factor 3 protein-coding transcription factor 3 Beside the role in apoptosis, A1, like Bcl-2, Mcl-1 or Bcl-xL can interact with Beclin1, thereby inhibiting induction of autophagy, possibly via the disruption of Beclin1/hVps34 complexes .In this animal model, we have expressed an shRNA targeting all A1 isoforms, embedded in the microRNA-30 (miR30) backbone, under control of the hematopoiesis-specific Vav-gene promoter. 2611 miR-302a mmu-miR-302a-3p,mmu-miR-302a-5p MIMAT0000380,MIMAT0004579 miRNA Lats2 apoptosis up Mus musculus mouse embryonic stem cells 22828209 10090 50523 4932411G09Rik|AV277261|AW228608 MGI:1354386|Ensembl:ENSMUSG00000021959|Vega:OTTMUSG00000037614 14 14 C3|14 large tumor suppressor 2 protein-coding large tumor suppressor 2 Furthermore, bioinformatics analyses and in vitro studies suggested that miR-302a plays a critical role in mediating the effects of folate on cell proliferation and cell cycle-specific apoptosis by targeting Lats2 gene. 2612 miR-320 mmu-miR-320-5p,mmu-miR-320-3p MIMAT0017057,MIMAT0000666 miRNA Fasn apoptosis down Mus musculus osteosarcoma cell 24390663 10090 14104 A630082H08Rik|FAS MGI:95485|Ensembl:ENSMUSG00000025153|Vega:OTTMUSG00000004143 11 11 E2|11 84.56 cM fatty acid synthase protein-coding fatty acid synthase Introduction of miR-320 mimics into U2OS and MG63 cells inhibited cell proliferation, while cell apoptosis rate remained unaltered. Additionally, miR-320 overexpression could also suppress tumor growth in the nude mice. At the molecular level, our results further revealed that the expression of fatty acid synthase (FASN), a key enzyme for de novo biosynthesis of fatty acids, was negatively regulated by miR-320. Therefore, our results suggest that miR-320 may act as a tumor suppressor for osteosarcoma. 2613 miR-34a mmu-miR-34a-5p,mmu-miR-34a-3p MIMAT0000542,MIMAT0017022 miRNA Trp53 apoptosis Mus musculus chronic lymphocytic leukemia cells 20089965 10090 22059 Tp53|bbl|bfy|bhy|p44|p53 MGI:98834|Ensembl:ENSMUSG00000059552|Vega:OTTMUSG00000005982 11 11 B2-C|11 42.83 cM transformation related protein 53 protein-coding transformation related protein 53 In chronic lymphocytic leukemia (B-CLL), aberrations along the p53 axis lead to decreased overall survival and therapy resistance. Recent studies identified microRNA-34a (miR-34a) as a major downstream target of p53. 2614 miR-34a mmu-miR-34a-5p,mmu-miR-34a-3p MIMAT0000542,MIMAT0017022 miRNA apoptosis down Mus musculus melanoma cells 20606648 10090 MiRNA-34a (miR-34a) induced apoptosis, inhibited survivin expression, and downregulated MAPK pathway in B16F10 cells. 2615 miR-351 mmu-miR-351-5p,mmu-miR-351-3p MIMAT0000609,MIMAT0017042 miRNA E2f3 apoptosis down Mus musculus myoblast cell line cells 22968638 10090 13557 E2F3b|E2f3a MGI:1096340|Ensembl:ENSMUSG00000016477|Vega:OTTMUSG00000000738 13 13|13 A3.3 E2F transcription factor 3 protein-coding E2F transcription factor 3 Moreover, knockdown of miR-351 expression inhibited MPC proliferation and promoted apoptosis during MPC differentiation, whereas miR-351 overexpression protected MPC from apoptosis during differentiation. 2616 miR-376a mmu-miR-376a-5p,mmu-miR-376a-3p MIMAT0003387,MIMAT0000740 miRNA Pcna apoptosis Mus musculus ovaries cell 24686458 10090 18538 - MGI:97503|Ensembl:ENSMUSG00000027342|Vega:OTTMUSG00000015547 2 2 F2|2 64.15 cM proliferating cell nuclear antigen protein-coding proliferating cell nuclear antigen Here, we report that microRNA 376a (miR-376a) regulates primordial follicle assembly by modulating the expression of proliferating cell nuclear antigen (Pcna), a gene we previously reported to regulate primordial follicle assembly by regulating oocyte apoptosis in mouse ovaries. miR-376a was shown to be negatively correlated with Pcna mRNA expression in fetal and neonatal mouse ovaries and to directly bind to Pcna mRNA 3' untranslated region. 2617 miR-378 mmu-miR-378-5p,mmu-miR-378-3p MIMAT0000742,MIMAT0003151 miRNA apoptosis Mus musculus nonylphenol -treated Sertoli cells 21914226 10090 Comprehensiveanalysis of predicted target genes for miRNAs showed that the expression of genes with roles in cell proliferation, the cell cycle, and cell death were regulated by miRNA in NP-treated TM4 cells. 2618 miR-424 mmu-miR-322-5p MIMAT0000548 miRNA Ccnd1 apoptosis down Mus musculus brain cells 23613494 10090 12443 AI327039|CycD1|Cyl-1|PRAD1|bcl-1|cD1 MGI:88313|Ensembl:ENSMUSG00000070348|Vega:OTTMUSG00000026018 7 7 F5|7 88.92 cM cyclin D1 protein-coding cyclin D1 Meanwhile, lentiviral overexpression of miR-424 inhibited neuronal apoptosis and microglia activation, including suppressing ionized calcium binding adaptor molecule-1 immunoreactivity and protein level, and reduced tumor necrosis factor-¦Á production. In vitro study demonstrated that miR-424 mimics caused G1 phase cell-cycle arrest, inhibited BV2 microglia activity, and reduced the mRNA and protein levels of CDC25A, cyclin D1, and CDK6 in BV2 microglial cells, which were upregulated in brain of middle cerebral artery occlusion mice. 2619 miR-424 mmu-miR-322-5p MIMAT0000548 miRNA Cdc25a apoptosis down Mus musculus brain cells 23613494 10090 12530 D9Ertd393e MGI:103198|Ensembl:ENSMUSG00000032477 9 9 F2|9 59.81 cM cell division cycle 25A protein-coding cell division cycle 25A Meanwhile, lentiviral overexpression of miR-424 inhibited neuronal apoptosis and microglia activation, including suppressing ionized calcium binding adaptor molecule-1 immunoreactivity and protein level, and reduced tumor necrosis factor-¦Á production. In vitro study demonstrated that miR-424 mimics caused G1 phase cell-cycle arrest, inhibited BV2 microglia activity, and reduced the mRNA and protein levels of CDC25A, cyclin D1, and CDK6 in BV2 microglial cells, which were upregulated in brain of middle cerebral artery occlusion mice. 2620 miR-424 mmu-miR-322-5p MIMAT0000548 miRNA Cdk6 apoptosis down Mus musculus brain cells 23613494 10090 12571 5830411I20|AI504062|Crk2 MGI:1277162|Ensembl:ENSMUSG00000040274 5 5 A2-A3|5 2.04 cM cyclin-dependent kinase 6 protein-coding cyclin-dependent kinase 6 Meanwhile, lentiviral overexpression of miR-424 inhibited neuronal apoptosis and microglia activation, including suppressing ionized calcium binding adaptor molecule-1 immunoreactivity and protein level, and reduced tumor necrosis factor-¦Á production. In vitro study demonstrated that miR-424 mimics caused G1 phase cell-cycle arrest, inhibited BV2 microglia activity, and reduced the mRNA and protein levels of CDC25A, cyclin D1, and CDK6 in BV2 microglial cells, which were upregulated in brain of middle cerebral artery occlusion mice. 2621 miR-424 mmu-miR-322-5p MIMAT0000548 miRNA Sod1 apoptosis up Mus musculus brain 25523055 10090 20655 B430204E11Rik|Cu/Zn-SOD|CuZnSOD|Ipo-1|Ipo1|SODC|Sod-1 MGI:98351|Ensembl:ENSMUSG00000022982 16 16 B5-C3|16 51.56 cM superoxide dismutase 1, soluble protein-coding superoxide dismutase 1, soluble Treatment with miR-424 decreased infarct volume and inhibited neuronal apoptosis after ischemia/reperfusion, reduced reactive oxygen species and malondialdehyde levels in the cortex, and increased the expression and activation of MnSOD as well as the expression of extracellular SOD and the redox-sensitive transcription factor nuclear factor erythroid 2-related factor. 2622 miR-424 mmu-miR-322-5p MIMAT0000548 miRNA Sod2 apoptosis up Mus musculus brain 25523055 10090 20656 MnSOD|Sod-2 MGI:98352|Ensembl:ENSMUSG00000006818 17 17 A1|17 8.75 cM superoxide dismutase 2, mitochondrial protein-coding superoxide dismutase 2, mitochondrial Treatment with miR-424 decreased infarct volume and inhibited neuronal apoptosis after ischemia/reperfusion, reduced reactive oxygen species and malondialdehyde levels in the cortex, and increased the expression and activation of MnSOD as well as the expression of extracellular SOD and the redox-sensitive transcription factor nuclear factor erythroid 2-related factor. 2623 miR-451 mmu-miR-451 MIMAT0001632 miRNA Rab14 apoptosis up Mus musculus non-small cell lung carcinoma cells 21358675 10090 68365 0610030G24Rik|2810475J17Rik|A830021G03Rik|AI314285|AI649155|D030017L14Rik MGI:1915615|Ensembl:ENSMUSG00000026878|Vega:OTTMUSG00000012919 2 2 B|2 RAB14, member RAS oncogene family protein-coding RAB14, member RAS oncogene family ras-related protein Rab-1 MicroRNA-451 functions as a tumor suppressor in human non-small cell lung cancer by targeting ras-related protein 14 (RAB14). 2624 miR-466h mmu-miR-466h-5p,mmu-miR-466h-3p MIMAT0004884,MIMAT0017274 miRNA Bcl2l2 apoptosis down Mus musculus mammalian cell 21337326 10090 12050 AW048834|Bcl-w|Gtrgal2|Gtrosa41|bclw|c98 MGI:108052|Ensembl:ENSMUSG00000089682|Vega:OTTMUSG00000032812 14 14 C3|14 27.98 cM BCL2-like 2 protein-coding BCL2-like 2 The qRT-PCR analysis revealed reduced mRNA levels of bcl2l2, dad1, birc6, stat5a, and smo genes in CHO cells exposed to depleted media. The inhibition of the mmu-miR-466h increased the expression levels of those genes and resulted in increased cell viability and decreased Caspase-3/7 activation. The up-regulation of mmu-miR-466h in response to nutrients depletion causes the inhibition of several anti-apoptotic genes in unison. 2625 miR-466h mmu-miR-466h-5p,mmu-miR-466h-3p MIMAT0004884,MIMAT0017274 miRNA Birc6 apoptosis down Mus musculus mammalian cell 21337326 10090 12211 A430032G04Rik|A430040A19Rik|AA501170|Bruce|D630005A10Rik|mKIAA1289 MGI:1276108|Ensembl:ENSMUSG00000024073|Vega:OTTMUSG00000042370 17 17 E3|17 baculoviral IAP repeat-containing 6 protein-coding baculoviral IAP repeat-containing 6 The qRT-PCR analysis revealed reduced mRNA levels of bcl2l2, dad1, birc6, stat5a, and smo genes in CHO cells exposed to depleted media. The inhibition of the mmu-miR-466h increased the expression levels of those genes and resulted in increased cell viability and decreased Caspase-3/7 activation. The up-regulation of mmu-miR-466h in response to nutrients depletion causes the inhibition of several anti-apoptotic genes in unison. 2626 miR-466h mmu-miR-466h-5p,mmu-miR-466h-3p MIMAT0004884,MIMAT0017274 miRNA Casp3 apoptosis up Mus musculus mammalian cell 21337326 10090 12367 A830040C14Rik|AC-3|Apopain|CASP-3|CC3|CPP-32|CPP32|Caspase-3|Lice|SCA-1|Yama|mldy MGI:107739 8 8 B1.1|8 26.39 cM caspase 3 protein-coding caspase 3 The qRT-PCR analysis revealed reduced mRNA levels of bcl2l2, dad1, birc6, stat5a, and smo genes in CHO cells exposed to depleted media. The inhibition of the mmu-miR-466h increased the expression levels of those genes and resulted in increased cell viability and decreased Caspase-3/7 activation. The up-regulation of mmu-miR-466h in response to nutrients depletion causes the inhibition of several anti-apoptotic genes in unison. 2627 miR-466h mmu-miR-466h-5p,mmu-miR-466h-3p MIMAT0004884,MIMAT0017274 miRNA Casp7 apoptosis up Mus musculus mammalian cell 21337326 10090 12369 AI314680|CMH-1|ICE-IAP3|Mch3|caspase-7|mCASP-7 MGI:109383|Ensembl:ENSMUSG00000025076 19 19 D2|19 51.84 cM caspase 7 protein-coding caspase 7 The qRT-PCR analysis revealed reduced mRNA levels of bcl2l2, dad1, birc6, stat5a, and smo genes in CHO cells exposed to depleted media. The inhibition of the mmu-miR-466h increased the expression levels of those genes and resulted in increased cell viability and decreased Caspase-3/7 activation. The up-regulation of mmu-miR-466h in response to nutrients depletion causes the inhibition of several anti-apoptotic genes in unison. 2628 miR-466h mmu-miR-466h-5p,mmu-miR-466h-3p MIMAT0004884,MIMAT0017274 miRNA Dad1 apoptosis down Mus musculus mammalian cell 21337326 10090 13135 AI323713 MGI:101912|Ensembl:ENSMUSG00000022174|Vega:OTTMUSG00000033740 14 14 C2|14 27.7 cM defender against cell death 1 protein-coding defender against cell death 1 The qRT-PCR analysis revealed reduced mRNA levels of bcl2l2, dad1, birc6, stat5a, and smo genes in CHO cells exposed to depleted media. The inhibition of the mmu-miR-466h increased the expression levels of those genes and resulted in increased cell viability and decreased Caspase-3/7 activation. The up-regulation of mmu-miR-466h in response to nutrients depletion causes the inhibition of several anti-apoptotic genes in unison. 2629 miR-466h mmu-miR-466h-5p,mmu-miR-466h-3p MIMAT0004884,MIMAT0017274 miRNA Smo apoptosis down Mus musculus mammalian cell 21337326 10090 319757 E130215L21Rik|Smoh|bnb|smoothened MGI:108075|Ensembl:ENSMUSG00000001761|Vega:OTTMUSG00000013446 6 6 A3.3|6 12.36 cM smoothened homolog (Drosophila) protein-coding smoothened homolog (Drosophila) The qRT-PCR analysis revealed reduced mRNA levels of bcl2l2, dad1, birc6, stat5a, and smo genes in CHO cells exposed to depleted media. The inhibition of the mmu-miR-466h increased the expression levels of those genes and resulted in increased cell viability and decreased Caspase-3/7 activation. The up-regulation of mmu-miR-466h in response to nutrients depletion causes the inhibition of several anti-apoptotic genes in unison. 2630 miR-466h mmu-miR-466h-5p,mmu-miR-466h-3p MIMAT0004884,MIMAT0017274 miRNA Stat5a apoptosis down Mus musculus mammalian cell 21337326 10090 20850 AA959963|STAT5 MGI:103036|Ensembl:ENSMUSG00000004043|Vega:OTTMUSG00000002125 11 11 D|11 63.77 cM signal transducer and activator of transcription 5A protein-coding signal transducer and activator of transcription 5A The qRT-PCR analysis revealed reduced mRNA levels of bcl2l2, dad1, birc6, stat5a, and smo genes in CHO cells exposed to depleted media. The inhibition of the mmu-miR-466h increased the expression levels of those genes and resulted in increased cell viability and decreased Caspase-3/7 activation. The up-regulation of mmu-miR-466h in response to nutrients depletion causes the inhibition of several anti-apoptotic genes in unison. 2631 miR-467a mmu-miR-467a-5p,mmu-miR-467a-3p MIMAT0003409,MIMAT0002108 miRNA Bax apoptosis down Mus musculus thymic lymphomas 25552935 10090 12028 - MGI:99702|Ensembl:ENSMUSG00000003873 7 7 B5|7 29.32 cM BCL2-associated X protein protein-coding BCL2-associated X protein MiR-467a is upregulated in radiation-induced mouse thymic lymphomas and regulates apoptosis by targeting Fas and Bax. 2632 miR-467a mmu-miR-467a-5p,mmu-miR-467a-3p MIMAT0003409,MIMAT0002108 miRNA Fas apoptosis down Mus musculus thymic lymphomas 25552935 10090 14102 AI196731|APO1|APT1|CD95|TNFR6|Tnfrsf6|lpr MGI:95484|Ensembl:ENSMUSG00000024778 19 19 C1|19 29.48 cM Fas (TNF receptor superfamily member 6) protein-coding Fas (TNF receptor superfamily member 6) MiR-467a is upregulated in radiation-induced mouse thymic lymphomas and regulates apoptosis by targeting Fas and Bax. 2633 miR-484 mmu-miR-484 MIMAT0003127 miRNA Fis1 apoptosis dowm Mus musculus adrenocortical cancer cells 22510686 10090 66437 2010003O14Rik|Ttc11 MGI:1913687|Ensembl:ENSMUSG00000019054|Vega:OTTMUSG00000023394 5 5|5 G1 fission 1 (mitochondrial outer membrane) homolog (yeast) protein-coding fission 1 (mitochondrial outer membrane) homolog (yeast) Fis1 is necessary for mitochondrial fission and apoptosis, and is upregulated during anoxia, whereas miR-484 is downregulated. miR-484 is able to attenuate Fis1 upregulation and mitochondrial fission, by binding to the amino acid coding sequence of Fis1 and inhibiting its translation. 2634 miR-494 mmu-miR-494-3p,mmu-miR-494-5p MIMAT0003182,MIMAT0017215 miRNA Atf3 apoptosis up Mus musculus 23160513 10090 11910 LRG-21 MGI:109384|Ensembl:ENSMUSG00000026628|Vega:OTTMUSG00000021405 1 1 H6|1 96.28 cM activating transcription factor 3 protein-coding activating transcription factor 3 In mice, overexpression of microRNA-494 significantly attenuated the level of ATF3 and induced inflammatory mediators, such as IL-6, monocyte chemotactic protein-1, and P-selectin, after renal ischemia/reperfusion, exacerbating apoptosis and further decreasing renal function. 2635 miR-494 mmu-miR-494-3p,mmu-miR-494-5p MIMAT0003182,MIMAT0017215 miRNA Camk2d apoptosis Mus musculus hearts 20837890 10090 108058 2810011D23Rik|8030469K03Rik|CaMK II|[d]-CaMKII MGI:1341265|Ensembl:ENSMUSG00000053819|Vega:OTTMUSG00000023550 3 3 G1-G2|3 calcium/calmodulin-dependent protein kinase II, delta protein-coding calcium/calmodulin-dependent protein kinase II, delta We further identified that 3 proapoptotic proteins (PTEN, ROCK1, and CaMKII¦Ä) and 2 antiapoptotic proteins (FGFR2 and LIF) were authentic targets for miR-494. 2636 miR-494 mmu-miR-494-3p,mmu-miR-494-5p MIMAT0003182,MIMAT0017215 miRNA Fgfr2 apoptosis Mus musculus hearts 20837890 10090 14183 AU043015|AW556123|Bek|Fgfr-2|Fgfr-7|Fgfr7|KGFR|KGFRTr|svs MGI:95523|Ensembl:ENSMUSG00000030849|Vega:OTTMUSG00000031222 7 7 F3|7 fibroblast growth factor receptor 2 protein-coding fibroblast growth factor receptor 2 We further identified that 3 proapoptotic proteins (PTEN, ROCK1, and CaMKII¦Ä) and 2 antiapoptotic proteins (FGFR2 and LIF) were authentic targets for miR-494. 2637 miR-494 mmu-miR-494-3p,mmu-miR-494-5p MIMAT0003182,MIMAT0017215 miRNA Lif apoptosis Mus musculus hearts 20837890 10090 16878 - MGI:96787|Ensembl:ENSMUSG00000034394|Vega:OTTMUSG00000005061 11 11 A1-A2|11 2.94 cM leukemia inhibitory factor protein-coding leukemia inhibitory factor We further identified that 3 proapoptotic proteins (PTEN, ROCK1, and CaMKII¦Ä) and 2 antiapoptotic proteins (FGFR2 and LIF) were authentic targets for miR-494. 2638 miR-494 mmu-miR-494-3p,mmu-miR-494-5p MIMAT0003182,MIMAT0017215 miRNA Pten apoptosis Mus musculus hearts 20837890 10090 19211 2310035O07Rik|A130070J02Rik|AI463227|B430203M17Rik|MMAC1|TEP1 MGI:109583|Ensembl:ENSMUSG00000013663|Vega:OTTMUSG00000021203 19 19 C1|19 28.14 cM phosphatase and tensin homolog protein-coding phosphatase and tensin homolog We further identified that 3 proapoptotic proteins (PTEN, ROCK1, and CaMKII¦Ä) and 2 antiapoptotic proteins (FGFR2 and LIF) were authentic targets for miR-494. 2639 miR-494 mmu-miR-494-3p,mmu-miR-494-5p MIMAT0003182,MIMAT0017215 miRNA Rock1 apoptosis Mus musculus hearts 20837890 10090 19877 1110055K06Rik|Rock-I MGI:107927|Ensembl:ENSMUSG00000024290 18 18|18 A2 Rho-associated coiled-coil containing protein kinase 1 protein-coding Rho-associated coiled-coil containing protein kinase 1 We further identified that 3 proapoptotic proteins (PTEN, ROCK1, and CaMKII¦Ä) and 2 antiapoptotic proteins (FGFR2 and LIF) were authentic targets for miR-494. 2640 miR-687 mmu-miR-687 MIMAT0003466 miRNA Hif1a apoptosis Mus musculus kidney cell 25587068 10090 15251 AA959795|HIF1alpha|MOP1|bHLHe78 MGI:106918|Ensembl:ENSMUSG00000021109|Vega:OTTMUSG00000019740 12 12 C3|12 31.99 cM hypoxia inducible factor 1, alpha subunit protein-coding hypoxia inducible factor 1, alpha subunit We show that miR-687 is markedly upregulated in the kidney during renal ischemia-reperfusion in mice and in cultured kidney cells during hypoxia. MiR-687 induction under these conditions was mediated by hypoxia-inducible factor-1 (HIF-1). Upon induction in vitro, miR-687 repressed the expression of phosphatase and tensin homolog (PTEN) and facilitated cell cycle progression and apoptosis. 2641 miR-687 mmu-miR-687 MIMAT0003466 miRNA Pten apoptosis down Mus musculus kidney cell 25587068 10090 19211 2310035O07Rik|A130070J02Rik|AI463227|B430203M17Rik|MMAC1|TEP1 MGI:109583|Ensembl:ENSMUSG00000013663|Vega:OTTMUSG00000021203 19 19 C1|19 28.14 cM phosphatase and tensin homolog protein-coding phosphatase and tensin homolog We show that miR-687 is markedly upregulated in the kidney during renal ischemia-reperfusion in mice and in cultured kidney cells during hypoxia. MiR-687 induction under these conditions was mediated by hypoxia-inducible factor-1 (HIF-1). Upon induction in vitro, miR-687 repressed the expression of phosphatase and tensin homolog (PTEN) and facilitated cell cycle progression and apoptosis. 2642 miR-702 mmu-miR-702-5p,mmu-miR-702-3p MIMAT0003492,MIMAT0022931 miRNA Atf6 apoptosis down Mus musculus 24035931 10090 226641 9130025P16Rik|9630036G24|AA789574|Atf6alpha|ESTM49 MGI:1926157|Ensembl:ENSMUSG00000026663|Vega:OTTMUSG00000043564 1 1 H3|1 76.96 cM activating transcription factor 6 protein-coding activating transcription factor 6 mmu-miR-702 inhibited apoptosis as well as the expression levels of a subset of apoptosis-related genes including activating transcription factor 6 (ATF6). 2643 miR-706 mmu-miR-706 MIMAT0003496 miRNA Casp3 apoptosis down Mus musculus BHK cells 20625776 10090 12367 A830040C14Rik|AC-3|Apopain|CASP-3|CC3|CPP-32|CPP32|Caspase-3|Lice|SCA-1|Yama|mldy MGI:107739 8 8 B1.1|8 26.39 cM caspase 3 protein-coding caspase 3 We further found that miR-706 inhibited VSV-induced apoptosis by decreasing caspase-3 and -9 activation, suggesting that induction of miR-706 expression may be a novel strategy for survival of VSV, allowing it to escape the apoptosis response of the host. 2644 miR-706 mmu-miR-706 MIMAT0003496 miRNA Casp9 apoptosis down Mus musculus BHK cells 20625776 10090 12371 AI115399|APAF-3|AW493809|CASP-9|Caspase-9|ICE-LAP6|Mch6 MGI:1277950|Ensembl:ENSMUSG00000028914|Vega:OTTMUSG00000009932 4 4 E1|4 caspase 9 protein-coding caspase 9 We further found that miR-706 inhibited VSV-induced apoptosis by decreasing caspase-3 and -9 activation, suggesting that induction of miR-706 expression may be a novel strategy for survival of VSV, allowing it to escape the apoptosis response of the host. 2645 miR-708 mmu-miR-708-3p,mmu-miR-708-5p MIMAT0003498,MIMAT0004828 miRNA Casp2 apoptosis down Mus musculus bladder carcinoma cells 23568547 10090 12366 Caspase-2|ICH-1|Nedd2 MGI:97295|Ensembl:ENSMUSG00000029863|Vega:OTTMUSG00000023653 6 6 B2.1|6 20.54 cM caspase 2 protein-coding caspase 2 miR-708 promotes the development of bladder carcinoma via direct repression of Caspase-2.Further results showed that Caspase-2 was involved in the miR-708 regulated cell apoptosis. 2646 miR-872 mmu-miR-872-5p,mmu-miR-872-3p MIMAT0004934,MIMAT0004935 miRNA Sod1 apoptosis up Mus musculus sertoli cells 20467044 10090 20655 B430204E11Rik|Cu/Zn-SOD|CuZnSOD|Ipo-1|Ipo1|SODC|Sod-1 MGI:98351|Ensembl:ENSMUSG00000022982 16 16 B5-C3|16 51.56 cM superoxide dismutase 1, soluble protein-coding superoxide dismutase 1, soluble Furthermore, through 3'UTR luciferase assays we identified one up-regulated protein, SOD-1, a Cu/Zn superoxide dismutase whose overexpression has been linked to enhanced cell death through apoptosis, as a likely direct target of three Sertoli cell-expressed miRNAs, miR-125a-3p, miR-872 and miR-24. 2647 miR-92 mmu-miR-92a-3p,mmu-miR-92a-2-5p,mmu-miR-92a-2-5p,mmu-miR-92a-1-5p,mmu-miR-92b-5p MIMAT0000539,MIMAT0000539,MIMAT0004899,MIMAT0017066,MIMAT0017278 miRNA Bcl2l11 apoptosis down Mus musculus CD4+ T cells 18327259 10090 12125 1500006F24Rik|Bim|Bod|bcl2-L-11 MGI:1197519|Ensembl:ENSMUSG00000027381|Vega:OTTMUSG00000015356 2 2|2 F3-G1 BCL2-like 11 (apoptosis facilitator) protein-coding BCL2-like 11 (apoptosis facilitator) Bcl2 interacting mediator The miR-17-92 miRNA suppressed expression of the tumor suppressor PTEN and the proapoptotic protein Bim. 2648 miR-92 mmu-miR-92a-3p,mmu-miR-92a-2-5p,mmu-miR-92a-2-5p,mmu-miR-92a-1-5p,mmu-miR-92b-5p MIMAT0000539,MIMAT0000539,MIMAT0004899,MIMAT0017066,MIMAT0017278 miRNA Pten apoptosis down Mus musculus CD4+ T cells 18327259 10090 19211 2310035O07Rik|A130070J02Rik|AI463227|B430203M17Rik|MMAC1|TEP1 MGI:109583|Ensembl:ENSMUSG00000013663|Vega:OTTMUSG00000021203 19 19 C1|19 28.14 cM phosphatase and tensin homolog protein-coding phosphatase and tensin homolog Bcl2 interacting mediator The miR-17-92 miRNA suppressed expression of the tumor suppressor PTEN and the proapoptotic protein Bim. 2649 miR-93 mmu-miR-93-5p,hsa-miR-93-3p MIMAT0000540,MIMAT0004509 miRNA apoptosis Mus musculus endothelial and skeletal muscle cells 23559675 10090 In vitro, overexpression of miR-93 attenuated hypoxia-induced apoptosis in both endothelial and skeletal muscle cells and enhanced proliferation in both cell types. 2650 let-7c mmu-let-7c-5p,mmu-let-7c-1-3p,mmu-let-7c-2-3p MIMAT0000523,MIMAT0004622,MIMAT0005439 miRNA Pou5f1 apoptosis up Mus musculus cardiac fibroblasts 25505600 10090 18999 NF-A3|Oct-3|Oct-3/4|Oct-4|Oct3|Oct3/4|Oct4|Otf-3|Otf-4|Otf3|Otf3-rs7|Otf3g|Otf4 MGI:101893|Ensembl:ENSMUSG00000024406|Vega:OTTMUSG00000037235 17 17 B1|17 18.69 cM POU domain, class 5, transcription factor 1 protein-coding POU domain, class 5, transcription factor 1 The inhibition of Let-7c miRNA downregulated the levels of mature Let-7c miRNA and its other closely related members of Let-7 family in the heart and resulted in increased expression of pluripotency-associated genes Oct4 and Sox2 in cardiac fibroblasts in vitro and in adult mouse heart in vivo. Improvement in cardiac function by Let-7c inhibitor postinfarction was associated with decreased apoptosis, reduced fibrosis, and reduction in the number of discoidin domain receptor 2-positive fibroblasts 2651 let-7c mmu-let-7c-5p,mmu-let-7c-1-3p,mmu-let-7c-2-3p MIMAT0000523,MIMAT0004622,MIMAT0005439 miRNA Sox2 apoptosis up Mus musculus cardiac fibroblasts 25505600 10090 20674 Sox-2|lcc|ysb MGI:98364|Ensembl:ENSMUSG00000074637|Vega:OTTMUSG00000021249 3 3 A2-B|3 16.93 cM SRY (sex determining region Y)-box 2 protein-coding SRY (sex determining region Y)-box 2 The inhibition of Let-7c miRNA downregulated the levels of mature Let-7c miRNA and its other closely related members of Let-7 family in the heart and resulted in increased expression of pluripotency-associated genes Oct4 and Sox2 in cardiac fibroblasts in vitro and in adult mouse heart in vivo.Improvement in cardiac function by Let-7c inhibitor postinfarction was associated with decreased apoptosis, reduced fibrosis, and reduction in the number of discoidin domain receptor 2-positive fibroblasts 2652 miR-1187 mmu-miR-1187 MIMAT0005837 miRNA Casp8 apoptosis down Mus musculus liver 22266786 10090 12370 CASP-8|FLICE|MACH|Mch5 MGI:1261423|Ensembl:ENSMUSG00000026029 1 1 B|1 29.19 cM caspase 8 protein-coding caspase 8 We show that miR-1187 regulates hepatocyte apoptosis by targetin caspase-8. 2653 miR-124 mmu-miR-124-3p£¬mmu-miR-124-5p£¬mmu-miR-1249-3p£¬mmu-miR-1247-5p£¬mmu-miR-1247-3p£¬mmu-miR-1249-5p MIMAT0000134,MIMAT0004527,MIMAT0010560,MIMAT0014800,MIMAT0014801,MIMAT0014804 miRNA Ptbp1 apoptosis Mus musculus colon cancer cell 25818238 10090 19205 AA407203|AL033359|HNRPI|PTB-1|PTB2|PTB3|PTB4|Ptb|pPTB MGI:97791|Ensembl:ENSMUSG00000006498|Vega:OTTMUSG00000035444 10 10 C1|10 39.72 cM polypyrimidine tract binding protein 1 protein-coding polypyrimidine tract binding protein 1 Also, miR-124 targeted polypyrimidine tract-binding protein 1 (PTB1), which is a splicer of pyruvate kinase muscle 1 and 2 (PKM1 and PKM2) and induced the switching of PKM isoforms expression from PKM2 to PKM1. Also, siR-PTB1 induced drastic apoptosis in colon cancer cells. 2654 miR-125b mmu-miR-125b-5p,mmu-miR-125b-2-3p,mmu-miR-125b-1-3p MIMAT0000136,MIMAT0004529,MIMAT0004669 miRNA Bak1 apoptosis Mus musculus 21935352 10090 12018 Bak|N-BAK1|N-Bak MGI:1097161|Ensembl:ENSMUSG00000057789|Vega:OTTMUSG00000030987 17 17|17 B BCL2-antagonist/killer 1 protein-coding BCL2-antagonist/killer 1 By using a gain- and loss-of-function screen for miR-125b targets in humans, mice, and zebrafish and by validating these targets with the luciferase assay and a novel miRNA pull-down assay, we demonstrate that miR-125b directly represses 20 novel targets in the p53 network. These targets include both apoptosis regulators like Bak1, Igfbp3, Itch, Puma, Prkra, Tp53inp1, Tp53, Zac1 2655 miR-125b mmu-miR-125b-5p,mmu-miR-125b-2-3p,mmu-miR-125b-1-3p MIMAT0000136,MIMAT0004529,MIMAT0004669 miRNA Bbc3 apoptosis Mus musculus 21935352 10090 170770 PUMA|PUMA/JFY1 MGI:2181667|Ensembl:ENSMUSG00000002083|Vega:OTTMUSG00000022267 7 7 A2|7 BCL2 binding component 3 protein-coding BCL2 binding component 3 By using a gain- and loss-of-function screen for miR-125b targets in humans, mice, and zebrafish and by validating these targets with the luciferase assay and a novel miRNA pull-down assay, we demonstrate that miR-125b directly represses 20 novel targets in the p53 network.These targets include both apoptosis regulators like Bak1, Igfbp3, Itch, Puma, Prkra, Tp53inp1, Tp53, Zac1 2656 miR-125b mmu-miR-125b-5p,mmu-miR-125b-2-3p,mmu-miR-125b-1-3p MIMAT0000136,MIMAT0004529,MIMAT0004669 miRNA Igfbp3 apoptosis Mus musculus 21935352 10090 16009 AI649005|IGFBP-3|IGgfbp3 MGI:96438|Ensembl:ENSMUSG00000020427|Vega:OTTMUSG00000005135 11 11 A1|11 4.75 cM insulin-like growth factor binding protein 3 protein-coding insulin-like growth factor binding protein 3 By using a gain- and loss-of-function screen for miR-125b targets in humans, mice, and zebrafish and by validating these targets with the luciferase assay and a novel miRNA pull-down assay, we demonstrate that miR-125b directly represses 20 novel targets in the p53 network.These targets include both apoptosis regulators like Bak1, Igfbp3, Itch, Puma, Prkra, Tp53inp1, Tp53, Zac1 2657 miR-125b mmu-miR-125b-5p,mmu-miR-125b-2-3p,mmu-miR-125b-1-3p MIMAT0000136,MIMAT0004529,MIMAT0004669 miRNA Itch apoptosis Mus musculus 21935352 10090 16396 6720481N21Rik|8030492O04Rik|A130065M08|AIP4|C230047C07Rik MGI:1202301|Ensembl:ENSMUSG00000027598|Vega:OTTMUSG00000016008 2 2 H1|2 76.94 cM itchy, E3 ubiquitin protein ligase protein-coding itchy, E3 ubiquitin protein ligase By using a gain- and loss-of-function screen for miR-125b targets in humans, mice, and zebrafish and by validating these targets with the luciferase assay and a novel miRNA pull-down assay, we demonstrate that miR-125b directly represses 20 novel targets in the p53 network.These targets include both apoptosis regulators like Bak1, Igfbp3, Itch, Puma, Prkra, Tp53inp1, Tp53, Zac1 2658 miR-125b mmu-miR-125b-5p,mmu-miR-125b-2-3p,mmu-miR-125b-1-3p MIMAT0000136,MIMAT0004529,MIMAT0004669 miRNA Prkra apoptosis Mus musculus 21935352 10090 23992 AV120107|PRK|Pact|RAX|lear MGI:1344375|Ensembl:ENSMUSG00000002731|Vega:OTTMUSG00000013128 2 2 C3|2 protein kinase, interferon inducible double stranded RNA dependent activator protein-coding protein kinase, interferon inducible double stranded RNA dependent activator By using a gain- and loss-of-function screen for miR-125b targets in humans, mice, and zebrafish and by validating these targets with the luciferase assay and a novel miRNA pull-down assay, we demonstrate that miR-125b directly represses 20 novel targets in the p53 network.These targets include both apoptosis regulators like Bak1, Igfbp3, Itch, Puma, Prkra, Tp53inp1, Tp53, Zac1 2659 miR-125b mmu-miR-125b-5p,mmu-miR-125b-2-3p,mmu-miR-125b-1-3p MIMAT0000136,MIMAT0004529,MIMAT0004669 miRNA Trp53inp1 apoptosis Mus musculus 21935352 10090 60599 2700057G22Rik|SIP|SIP18|SIP27|Stinp|Teap MGI:1926609|Ensembl:ENSMUSG00000028211|Vega:OTTMUSG00000004505 4 4|4 A1-A2 transformation related protein 53 inducible nuclear protein 1 protein-coding transformation related protein 53 inducible nuclear protein 1 By using a gain- and loss-of-function screen for miR-125b targets in humans, mice, and zebrafish and by validating these targets with the luciferase assay and a novel miRNA pull-down assay, we demonstrate that miR-125b directly represses 20 novel targets in the p53 network.These targets include both apoptosis regulators like Bak1, Igfbp3, Itch, Puma, Prkra, Tp53inp1, Tp53, Zac1 2660 miR-126 mmu-miR-126a-5p,mmu-miR-126a-3p,mmu-miR-126b-5p,mmu-miR-126b-3p MIMAT0000137,MIMAT0000138,MIMAT0029894,MIMAT0029895 miRNA Plk2 apoptosis Mus musculus bone marrow progenitor cells 18832181 10090 20620 Snk MGI:1099790|Ensembl:ENSMUSG00000021701 13 13|13 D2.1 polo-like kinase 2 protein-coding polo-like kinase 2 Our gain- and loss-of-function experiments showed that miR-126/126* inhibited apoptosis and increased the viability of AML cells and enhanced the colony-forming ability of mouse normal bone marrow progenitor cells alone and particularly, in cooperation with AML1-ETO, likely through targeting Polo-like kinase 2 (PLK2), a tumor suppressor. 2661 miR-126-3p mmu-miR-126a-3p,mmu-miR-126b-3p MIMAT0000138,MIMAT0029895 miRNA Plk2 apoptosis Mus musculus bone marrow progenitor cells 18832181 10090 20620 Snk MGI:1099790|Ensembl:ENSMUSG00000021701 13 13|13 D2.1 polo-like kinase 2 protein-coding polo-like kinase 2 Our gain- and loss-of-function experiments showed that miR-126/126* inhibited apoptosis and increased the viability of AML cells and enhanced the colony-forming ability of mouse normal bone marrow progenitor cells alone and particularly, in cooperation with AML1-ETO, likely through targeting Polo-like kinase 2 (PLK2), a tumor suppressor. 2662 miR-16 mmu-miR-16-5p,mmu-miR-16-1-3p,mmu-miR-16-2-3p MIMAT0000527,MIMAT0004625,MIMAT0017018 miRNA apoptosis Mus musculus malignant B-1 cell line 17351108 10090 Exogenous miR-16 delivered to an NZB malignant B-1 cell line resulted in cell-cycle alterations and increased apoptosis. 2663 miR-181a mmu-miR-181a-5p,mmu-miR-181a-1-3p,mmu-miR-181a-2-3p MIMAT0000210,MIMAT0000660,MIMAT0005443 miRNA Bax apoptosis down Mus musculus brain 21415464 10090 12028 - MGI:99702|Ensembl:ENSMUSG00000003873 7 7 B5|7 29.32 cM BCL2-associated X protein protein-coding BCL2-associated X protein We report here that down-regulation of miR-34a, -30e, and -181a permits their shared target gene expression (Bcl-2) to remain at a high level without post-transcriptional repression, accompanied by concomitant low levels of Bax expression and Caspase cleaving; 2664 miR-181a mmu-miR-181a-5p,mmu-miR-181a-1-3p,mmu-miR-181a-2-3p MIMAT0000210,MIMAT0000660,MIMAT0005443 miRNA Bcl2 apoptosis down Mus musculus brain 21415464 10090 12043 AW986256|Bcl-2|C430015F12Rik|D630044D05Rik|D830018M01Rik MGI:88138|Ensembl:ENSMUSG00000057329|Vega:OTTMUSG00000022128 1 1 E2.1|1 49.76 cM B cell leukemia/lymphoma 2 protein-coding B cell leukemia/lymphoma 2 We report here that down-regulation of miR-34a, -30e, and -181a permits their shared target gene expression (Bcl-2) to remain at a high level without post-transcriptional repression, accompanied by concomitant low levels of Bax expression and Caspase cleaving; 2665 miR-181a mmu-miR-181a-5p,mmu-miR-181a-1-3p,mmu-miR-181a-2-3p MIMAT0000210,MIMAT0000660,MIMAT0005443 miRNA Casp1 apoptosis Mus musculus brain 21415464 10090 12362 ICE|Il1bc MGI:96544|Ensembl:ENSMUSG00000025888 9 9 A1|9 2.46 cM caspase 1 protein-coding caspase 1 We report here that down-regulation of miR-34a, -30e, and -181a permits their shared target gene expression (Bcl-2) to remain at a high level without post-transcriptional repression, accompanied by concomitant low levels of Bax expression and Caspase cleaving; 2666 miR-181a mmu-miR-181a-5p,mmu-miR-181a-1-3p,mmu-miR-181a-2-3p MIMAT0000210,MIMAT0000660,MIMAT0005443 miRNA Casp3 apoptosis Mus musculus brain 21415464 10090 12367 A830040C14Rik|AC-3|Apopain|CASP-3|CC3|CPP-32|CPP32|Caspase-3|Lice|SCA-1|Yama|mldy MGI:107739 8 8 B1.1|8 26.39 cM caspase 3 protein-coding caspase 3 We report here that down-regulation of miR-34a, -30e, and -181a permits their shared target gene expression (Bcl-2) to remain at a high level without post-transcriptional repression, accompanied by concomitant low levels of Bax expression and Caspase cleaving; 2667 miR-23a hsa-miR-23a-3p,hsa-miR-23a-5p MIMAT0000078,MIMAT0004496 miRNA Bmp4 apoptosis down Mus musculus mouse embryonic stem cells 25476774 10090 12159 Bmp-4|Bmp2b|Bmp2b-1|Bmp2b1 MGI:88180|Ensembl:ENSMUSG00000021835|Vega:OTTMUSG00000019526 14 14 C1|14 23.95 cM bone morphogenetic protein 4 protein-coding bone morphogenetic protein 4 Here, through a systematic analysis of miRNAs in ESCs, we establish that BMP4 signaling regulates miR-23a, 27a and 24-2, through the recruitment of phospho-Smads at the promoter of the gene encoding this miRNA cluster. BMP4 has been previously reported to cause apoptosis during ESC differentiation. By blocking BMP4 signaling, we completely prevent the apoptosis induced by suppression of the miRs. This suggests that the effects of miR suppression are the result of enhanced BMP4 signaling. 2668 miR-24-2 hsa-miR-24-2-5p,hsa-miR-24-3p MIMAT0004497,MIMAT0000080 miRNA Bmp4 apoptosis down Mus musculus mouse embryonic stem cells 25476774 10090 12159 Bmp-4|Bmp2b|Bmp2b-1|Bmp2b1 MGI:88180|Ensembl:ENSMUSG00000021835|Vega:OTTMUSG00000019526 14 14 C1|14 23.95 cM bone morphogenetic protein 4 protein-coding bone morphogenetic protein 4 Here, through a systematic analysis of miRNAs in ESCs, we establish that BMP4 signaling regulates miR-23a, 27a and 24-2, through the recruitment of phospho-Smads at the promoter of the gene encoding this miRNA cluster.BMP4 has been previously reported to cause apoptosis during ESC differentiation. By blocking BMP4 signaling, we completelprevent the apoptosis induced by suppression of the miRs. This suggests that the effects of miR suppression are the result of enhanced BMP4 signaling. 2669 miR-27a hsa-miR-27a-5p,hsa-miR-27a-3p MIMAT0004501,MIMAT0000084 miRNA Bmp4 apoptosis down Mus musculus mouse embryonic stem cells 25476774 10090 12159 Bmp-4|Bmp2b|Bmp2b-1|Bmp2b1 MGI:88180|Ensembl:ENSMUSG00000021835|Vega:OTTMUSG00000019526 14 14 C1|14 23.95 cM bone morphogenetic protein 4 protein-coding bone morphogenetic protein 4 Here, through a systematic analysis of miRNAs in ESCs, we establish that BMP4 signaling regulates miR-23a, 27a and 24-2, through the recruitment of phospho-Smads at the promoter of the gene encoding this miRNA cluster.BMP4 has been previously reported to cause apoptosis during ESC differentiation. By blocking BMP4 signaling, we completelprevent the apoptosis induced by suppression of the miRs. This suggests that the effects of miR suppression are the result of enhanced BMP4 signaling. 2670 miR-30e mmu-miR-30e-5p,mmu-miR-30e-3p MIMAT0000248,MIMAT0000249 miRNA Bax apoptosis down Mus musculus brain 21415464 10090 12028 - MGI:99702|Ensembl:ENSMUSG00000003873 7 7 B5|7 29.32 cM BCL2-associated X protein protein-coding BCL2-associated X protein We report here that down-regulation of miR-34a, -30e, and -181a permits their shared target gene expression (Bcl-2) to remain at a high level without post-transcriptional repression, accompanied by concomitant low levels of Bax expression and Caspase cleaving; 2671 miR-30e mmu-miR-30e-5p,mmu-miR-30e-3p MIMAT0000248,MIMAT0000249 miRNA Bcl2 apoptosis down Mus musculus brain 21415464 10090 12043 AW986256|Bcl-2|C430015F12Rik|D630044D05Rik|D830018M01Rik MGI:88138|Ensembl:ENSMUSG00000057329|Vega:OTTMUSG00000022128 1 1 E2.1|1 49.76 cM B cell leukemia/lymphoma 2 protein-coding B cell leukemia/lymphoma 2 We report here that down-regulation of miR-34a, -30e, and -181a permits their shared target gene expression (Bcl-2) to remain at a high level without post-transcriptional repression, accompanied by concomitant low levels of Bax expression and Caspase cleaving; 2672 miR-30e mmu-miR-30e-5p,mmu-miR-30e-3p MIMAT0000248,MIMAT0000249 miRNA Casp1 apoptosis Mus musculus brain 21415464 10090 12362 ICE|Il1bc MGI:96544|Ensembl:ENSMUSG00000025888 9 9 A1|9 2.46 cM caspase 1 protein-coding caspase 1 We report here that down-regulation of miR-34a, -30e, and -181a permits their shared target gene expression (Bcl-2) to remain at a high level without post-transcriptional repression, accompanied by concomitant low levels of Bax expression and Caspase cleaving; 2673 miR-30e mmu-miR-30e-5p,mmu-miR-30e-3p MIMAT0000248,MIMAT0000249 miRNA Casp3 apoptosis Mus musculus brain 21415464 10090 12367 A830040C14Rik|AC-3|Apopain|CASP-3|CC3|CPP-32|CPP32|Caspase-3|Lice|SCA-1|Yama|mldy MGI:107739 8 8 B1.1|8 26.39 cM caspase 3 protein-coding caspase 3 We report here that down-regulation of miR-34a, -30e, and -181a permits their shared target gene expression (Bcl-2) to remain at a high level without post-transcriptional repression, accompanied by concomitant low levels of Bax expression and Caspase cleaving; 2674 miR-34a mmu-miR-34a-5p,mmu-miR-34a-3p MIMAT0000542,MIMAT0017022 miRNA Bax apoptosis down Mus musculus brain 21415464 10090 12028 - MGI:99702|Ensembl:ENSMUSG00000003873 7 7 B5|7 29.32 cM BCL2-associated X protein protein-coding BCL2-associated X protein We report here that down-regulation of miR-34a, -30e, and -181a permits their shared target gene expression (Bcl-2) to remain at a high level without post-transcriptional repression, accompanied by concomitant low levels of Bax expression and Caspase cleaving; 2675 miR-34a mmu-miR-34a-5p,mmu-miR-34a-3p MIMAT0000542,MIMAT0017022 miRNA Bcl2 apoptosis down Mus musculus brain 21415464 10090 12043 AW986256|Bcl-2|C430015F12Rik|D630044D05Rik|D830018M01Rik MGI:88138|Ensembl:ENSMUSG00000057329|Vega:OTTMUSG00000022128 1 1 E2.1|1 49.76 cM B cell leukemia/lymphoma 2 protein-coding B cell leukemia/lymphoma 2 We report here that down-regulation of miR-34a, -30e, and -181a permits their shared target gene expression (Bcl-2) to remain at a high level without post-transcriptional repression, accompanied by concomitant low levels of Bax expression and Caspase cleaving; 2676 miR-34a mmu-miR-34a-5p,mmu-miR-34a-3p MIMAT0000542,MIMAT0017022 miRNA Casp1 apoptosis Mus musculus brain 21415464 10090 12362 ICE|Il1bc MGI:96544|Ensembl:ENSMUSG00000025888 9 9 A1|9 2.46 cM caspase 1 protein-coding caspase 1 We report here that down-regulation of miR-34a, -30e, and -181a permits their shared target gene expression (Bcl-2) to remain at a high level without post-transcriptional repression, accompanied by concomitant low levels of Bax expression and Caspase cleaving; 2677 miR-34a mmu-miR-34a-5p,mmu-miR-34a-3p MIMAT0000542,MIMAT0017022 miRNA Casp3 apoptosis Mus musculus brain 21415464 10090 12367 A830040C14Rik|AC-3|Apopain|CASP-3|CC3|CPP-32|CPP32|Caspase-3|Lice|SCA-1|Yama|mldy MGI:107739 8 8 B1.1|8 26.39 cM caspase 3 protein-coding caspase 3 We report here that down-regulation of miR-34a, -30e, and -181a permits their shared target gene expression (Bcl-2) to remain at a high level without post-transcriptional repression, accompanied by concomitant low levels of Bax expression and Caspase cleaving; 2678 miR-34a mmu-miR-34a-5p,mmu-miR-34a-3p MIMAT0000542,MIMAT0017022 miRNA Sirt1 apoptosis down Mus musculus mouse eye 25489229 10090 93759 AA673258|SIR2L1|Sir2|Sir2a|Sir2alpha MGI:2135607|Ensembl:ENSMUSG00000020063|Vega:OTTMUSG00000030914 10 10 B4|10 sirtuin 1 protein-coding sirtuin 1 MiR-34a belongs to a signaling network involving p53 and Sirt-1. This network responds to DNA damage with further downstream signals that induce senescence or apoptosis.An inverse relationship between the levels of expression of miR-34a and its target Sirt1 mRNA was found at 18 and 24 months of age. 2679 miR-34a mmu-miR-34a-5p,mmu-miR-34a-3p MIMAT0000542,MIMAT0017022 miRNA Sirt1 apoptosis down Mus musculus HEI-OC1 cell line 25638533 10090 93759 AA673258|SIR2L1|Sir2|Sir2a|Sir2alpha MGI:2135607|Ensembl:ENSMUSG00000020063|Vega:OTTMUSG00000030914 10 10 B4|10 sirtuin 1 protein-coding sirtuin 1 In the inner ear HEI-OC1 cell line, miR-34a overexpression inhibited SIRT1,leading to an increase in p53 acetylation and apoptosis. 2680 miR-34a mmu-miR-34a-5p,mmu-miR-34a-3p MIMAT0000542,MIMAT0017022 miRNA apoptosis Mus musculus 25448438 10090 A pro-apoptotic miR-34a was the only miRNA that was up-regulated at all cumulative DOX doses and showed a significant dose-related response. 2681 miR-34c mmu-miR-34c-5p,mmu-miR-34c-3p MIMAT0000381,MIMAT0004580 miRNA Atf1 apoptosis down Mus musculus germ cell 22479460 10090 11908 - MGI:1298366|Ensembl:ENSMUSG00000023027|Vega:OTTMUSG00000036768 15 15 F3|15 activating transcription factor 1 protein-coding activating transcription factor 1 Furthermore, ectopic expression of miR-34c reduces ATF1 protein expression without affecting ATF1 mRNA level via directly binding to ATF1's 3'UTR, indicating that ATF1 is one of miR-34c's target genes. Meanwhile, the knockdown of ATF1 significantly decreases the Bcl-2/Bax ratio and triggers GC-2 cell apoptosis. 2682 miR-7 mmu-miR-7a-5p,mmu-miR-7a-1-3p,mmu-miR-7a-2-3p MIMAT0000677,MIMAT0004670,MIMAT0017070 miRNA Egfr apoptosis down Mus musculus lung cancer 25334070 10090 13649 9030024J15Rik|AI552599|Erbb|Errb1|Errp|Wa5|wa-2|wa2 MGI:95294|Ensembl:ENSMUSG00000020122|Vega:OTTMUSG00000005185 11 11 A1-A4|11 9.41 cM epidermal growth factor receptor protein-coding epidermal growth factor receptor Restoration of miR-7 inhibited 3LL cell proliferation, induced cell apoptosis in vitro and reduced tumorigenicity in vivo. We further confirmed that miR-7 downregulated the expression of both epidermal growth factor receptor (EGFR) and murine leukemia viral oncogene homologue-1 (RAF-1) oncogenes by real-time PCR and western blot analysis. Furthermore, inhibition of EGFR showed similar effects to miR-7 enforcement in 3LL cells. 2683 miR-7 mmu-miR-7a-5p,mmu-miR-7a-1-3p,mmu-miR-7a-2-3p MIMAT0000677,MIMAT0004670,MIMAT0017070 miRNA Raf1 apoptosis down Mus musculus lung cancer 25334070 10090 110157 6430402F14Rik|AA990557|BB129353|Craf1|D830050J10Rik|Raf-1|c-Raf|v-Raf MGI:97847|Ensembl:ENSMUSG00000000441|Vega:OTTMUSG00000020697 6 6 C3|6 53.62 cM v-raf-leukemia viral oncogene 1 protein-coding v-raf-leukemia viral oncogene 1 Restoration of miR-7 inhibited 3LL cell proliferation, induced cell apoptosis in vitro and reduced tumorigenicity in vivo. We further confirmed that miR-7 downregulated the expression of both epidermal growth factor receptor (EGFR) and murine leukemia viral oncogene homologue-1 (RAF-1) oncogenes by real-time PCR and western blot analysis. Furthermore, inhibition of EGFR showed similar effects to miR-7 enforcement in 3LL cells. 2684 miR-204 rno-miR-204 MIMAT0000877 miRNA Map1lc3b autophagy down Rattus norvegicus neonatal cardiomyocytes 21316776 10116 64862 Map1lc3|Mpl3|zbs559 RGD:621315|Ensembl:ENSRNOG00000017905 19 19q12 microtubule-associated protein 1 light chain 3 beta protein-coding microtubule-associated protein 1 light chain 3 beta MAP1 light chain 3-like p MiR-204 regulate cardiomyocyte autophagy induced by hypoxia-reoxygenation through LC3-II. 2685 miR-21 rno-miR-21-5p,rno-miR-21-3p MIMAT0000790,MIMAT0004711 miRNA Akt1 autophagy down Rattus norvegicus glomerular mesangial cell 25689721 10116 24185 Akt RGD:2081|Ensembl:ENSRNOG00000028629 6 6q32 v-akt murine thymoma viral oncogene homolog 1 protein-coding v-akt murine thymoma viral oncogene homolog 1 Ursolic acid inhibits the glucose-induced up-regulation of mesangial cell miRNA-21 expression, up-regulates PTEN expression, inhibits the activation of PI3K/Akt/mTOR signaling pathway, and enhances autophagy to reduce the accumulation of the extracellular matrix and ameliorate cell hypertrophy and proliferation. 2686 miR-21 rno-miR-21-5p,rno-miR-21-3p MIMAT0000790,MIMAT0004711 miRNA Mtor autophagy down Rattus norvegicus glomerular mesangial cell 25689721 10116 56718 Frap1|RAFT1 RGD:68371|Ensembl:ENSRNOG00000009615 5 5q36 mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) Ursolic acid inhibits the glucose-induced up-regulation of mesangial cell miRNA-21 expression, up-regulates PTEN expression, inhibits the activation of PI3K/Akt/mTOR signaling pathway, and enhances autophagy to reduce the accumulation of the extracellular matrix and ameliorate cell hypertrophy and proliferation. 2687 miR-21 rno-miR-21-5p,rno-miR-21-3p MIMAT0000790,MIMAT0004711 miRNA Pik3cg autophagy down Rattus norvegicus glomerular mesangial cell 25689721 10116 298947 Pi3k RGD:1306468 6 6q16 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma protein-coding phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma Ursolic acid inhibits the glucose-induced up-regulation of mesangial cell miRNA-21 expression, up-regulates PTEN expression, inhibits the activation of PI3K/Akt/mTOR signaling pathway, and enhances autophagy to reduce the accumulation of the extracellular matrix and ameliorate cell hypertrophy and proliferation. 2688 miR-21 rno-miR-21-5p,rno-miR-21-3p MIMAT0000790,MIMAT0004711 miRNA Pten autophagy up Rattus norvegicus glomerular mesangial cell 25689721 10116 50557 MMAC1|Mmac|TEP1 RGD:61995|Ensembl:ENSRNOG00000020723 1 1q41-q43 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog Ursolic acid inhibits the glucose-induced up-regulation of mesangial cell miRNA-21 expression, up-regulates PTEN expression, inhibits the activation of PI3K/Akt/mTOR signaling pathway, and enhances autophagy to reduce the accumulation of the extracellular matrix and ameliorate cell hypertrophy and proliferation. 2689 miR-30a rno-miR-30a-3p,rno-miR-30a-5p MIMAT0000809,MIMAT0000808 miRNA Becn1 autophagy down Rattus norvegicus cardiomyocyte 25501305 10116 114558 - RGD:620190|Ensembl:ENSRNOG00000020513 10 10q32.1 beclin 1, autophagy related protein-coding beclin 1, autophagy related In this study, we found that Ang II induced cardiomyocyte autophagy,together with down-regulation of MiR-30a and upregulation of the Beclin-1protein. We also found that the Beclin-1 protein is regulated by MiR-30a, by ransferring a MiR-30a mimic or AMO-204 into the cardiomyocytes. 2690 miR-34a rno-miR-34a-5p,rno-miR-34a-3p MIMAT0000815,MIMAT0017106 miRNA Atg9a autophagy down Rattus norvegicus cardiomyocytes 24728149 10116 363254 RGD1310450 RGD:1310450|Ensembl:ENSRNOG00000018975 9 9q33 autophagy related 9A protein-coding autophagy related 9A Moreover, miR-34a was able to bind to ATG9A 3'-UTR, but not to the mutated 3'-UTR and inhibited ATG9A protein expression and autophagic activity. 2691 miR-140-3p rno-miR-140-3p MIMAT0000574 miRNA Hmox1 autophagy Rattus norvegicus astrocyte 25820186 10116 24451 HEOXG|Heox|Hmox|Ho-1|Ho1|hsp32 RGD:2806|Ensembl:ENSRNOG00000014117 19 19p11 heme oxygenase (decycling) 1 protein-coding heme oxygenase (decycling) 1 - Over-expression of the heme-degrading enzyme, heme oxygenase-1 (HO-1) promotes iron deposition, mitochondrial damage, and autophagy in astrocytes and enhances the vulnerability of nearby neuronal constituents to oxidative injury. In HMOX1-transfected astrocytes, rno-miR-140*, rno-miR-17, and rno-miR-16 were significantly up-regulated, and rno-miR-297, rno-miR-206, rno-miR-187, rno-miR-181a, rno-miR-138 and rno-miR-29c were down-regulated, compared to sham-transfected controls. 2692 miR-16 rno-miR-16-5p,rno-miR-16-3p MIMAT0000785,MIMAT0017094 miRNA Hmox1 autophagy Rattus norvegicus astrocyte 25820186 10116 24451 HEOXG|Heox|Hmox|Ho-1|Ho1|hsp32 RGD:2806|Ensembl:ENSRNOG00000014117 19 19p11 heme oxygenase (decycling) 1 protein-coding heme oxygenase (decycling) 1 Over-expression of the heme-degrading enzyme, heme oxygenase-1 (HO-1) promotes iron deposition, mitochondrial damage, and autophagy in astrocytes and enhances the vulnerability of nearby neuronal constituents to oxidative injury. In HMOX1-transfected astrocytes, rno-miR-140*, rno-miR-17, and rno-miR-16 were significantly up-regulated, and rno-miR-297, rno-miR-206, rno-miR-187, rno-miR-181a, rno-miR-138 and rno-miR-29c were down-regulated, compared to sham-transfected controls. 2693 miR-17 rno-miR-17-5p,rno-miR-17-1-3p ,rno-miR-17-2-3p MIMAT0000786,MIMAT0004710,MIMAT0017295 miRNA Hmox1 autophagy Rattus norvegicus astrocyte 25820186 10116 24451 HEOXG|Heox|Hmox|Ho-1|Ho1|hsp32 RGD:2806|Ensembl:ENSRNOG00000014117 19 19p11 heme oxygenase (decycling) 1 protein-coding heme oxygenase (decycling) 1 Over-expression of the heme-degrading enzyme, heme oxygenase-1 (HO-1) promotes iron deposition, mitochondrial damage, and autophagy in astrocytes and enhances the vulnerability of nearby neuronal constituents to oxidative injury. In HMOX1-transfected astrocytes, rno-miR-140*, rno-miR-17, and rno-miR-16 were significantly up-regulated, and rno-miR-297, rno-miR-206, rno-miR-187, rno-miR-181a, rno-miR-138 and rno-miR-29c were down-regulated, compared to sham-transfected controls. 2694 beta2.7 http://lncrna.com/beta27rna/ lncRNA Ros1 apoptosis down Rattus norvegicus rat aortic endothelial cells 20036157 10116 25346 ROS1C RGD:3591 20 20q11 ROS proto-oncogene 1 , receptor tyrosine kinase protein-coding ROS proto-oncogene 1 , receptor tyrosine kinase beta2.7 RNA is a novel effector molecule that can protect rat aortic endothelial cells from I/R injury causing apoptosis. As a non-coding RNA, beta2.7 RNA will not induce an immune response in the recipient. We have shown that overexpression of beta2.7 RNA can protect RAEC from H/R- or I/R-mediated apoptosis by reduction of ROS formation. 2695 miR-1 rno-miR-1-5p,rno-miR-1-3p MIMAT0003162,MIMAT0003125 miRNA Bcl2 apoptosis down Rattus norvegicus cardiomyocyte cell line cells 19506341 10116 24224 Bcl-2 RGD:2199|Ensembl:ENSRNOG00000002791 13 13p13 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Inhibition of miR-1 by antisense inhibitory oligonucleotides caused marked resistance to H(2)O(2). Through bioinformatics, we identified the potential target sites for miR-1 on the 3' UTR of Bcl-2. miR-1 significantly reduced the expression of Bcl-2 in the levels of mRNA and protein. The post-transcriptional repression of Bcl-2 was further confirmed by luciferase reporter experiments. These data demonstrated that miR-1 plays an important role in the regulation of cardiomyocyte apoptosis, which is involved in post-transcriptional repression of Bcl-2. 2696 miR-1 rno-miR-1-5p,rno-miR-1-3p MIMAT0003162,MIMAT0003125 miRNA Igf1 apoptosis up Rattus norvegicus cardiomyocyte cell line cells 18801338 10116 24482 - RGD:2868|Ensembl:ENSRNOG00000004517 7 7q12-q13 insulin-like growth factor 1 protein-coding insulin-like growth factor 1 IGF-1 inhibits glucose-induced mitochondrial dysfunction, cytochrome-c release and apoptosis and IGF-1's effect is regulated by miR-1. 2697 miR-125a rno-miR-125a-5p,rno-miR-125a-3p MIMAT0000829,MIMAT0004729 miRNA Mcl1 apoptosis down Rattus norvegicus intestinal epithelium cells 22418008 10116 60430 - RGD:620525 2 2q34 myeloid cell leukemia sequence 1 protein-coding myeloid cell leukemia sequence 1 induced myeloid leukemia Upregulation of miR-125a suppresses the prosurvival protein mcl1, producing the increase in apoptosis known to accompany the proliferative changes characteristic of intestinal adaptation. 2698 miR-132 rno-miR-132-3p,rno-miR-132-5p MIMAT0000838,MIMAT0017123 miRNA Lrrfip1 apoptosis down Rattus norvegicus vascular smooth muscle cell 23880186 10116 367314 - RGD:1359548|Ensembl:ENSRNOG00000019892 9 9q36 leucine rich repeat (in FLII) interacting protein 1 protein-coding leucine rich repeat (in FLII) interacting protein 1 Bioinformatics showed that LRRFIP1 is a target candidate of miR-132. miR-132 down-regulated luciferase activity driven by a vector containing the 3'-untranslated region of Lrrfip1 in a sequence-specific manner. 2699 miR-146a rno-miR-146a-5p,rno-miR-146a-3p MIMAT0000852,MIMAT0017132 miRNA Smad4 apoptosis Rattus norvegicus hepatic stellate cells 22735812 10116 50554 Madh4 RGD:3033|Ensembl:ENSRNOG00000015634 18 18q12.3 SMAD family member 4 protein-coding SMAD family member 4 Furthermore, overexpression of miR-146a suppressed TGF-¦Â-induced HSC proliferation, and increased HSC apoptosis. Bioinformatics analyses predict that SMAD4 is the potential target of miR-146a. MiR-146a overexpression in TGF-¦Â1-treated HSC did not decrease target mRNA levels, but significantly reduced target protein expression. These results suggested that miR-146a may function as a novel regulator to modulate HSC activation during TGF-¦Â1 induction by targeting SMAD4. 2700 miR-146b rno-miR-146b-5p,rno-miR-146b-3p MIMAT0005595,MIMAT0017334 miRNA Tnfsf10 apoptosis up Rattus norvegicus thyroid cells 23543665 10116 246775 Trail RGD:628734|Ensembl:ENSRNOG00000013269 2 2q24 tumor necrosis factor (ligand) superfamily, member 10 protein-coding tumor necrosis factor (ligand) superfamily, member 10 Up-regulation of miR-146b and Down-regulation of miR-200b Contribute to the Cytotoxic Effect of Histone Deacetylase Inhibitors on ras-Transformed Thyroid Cells.The stabilization of TNF-related apoptosis-inducing ligand (TRAIL) protein, due to its reduced ubiquitination and proteasome degradation 2701 miR-15a rno-miR-15a-5p,rno-miR-15a-3p MIMAT0035728,MIMAT0035729 miRNA Bcl2 apoptosis down Rattus norvegicus HSC-T6 cells 25704029 10116 24224 Bcl-2 RGD:2199|Ensembl:ENSRNOG00000002791 13 13p13 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 BCL2 promotor methylation and miR-15a/16-1 upregulation is associated with sanguinarine-induced apoptotic death in rat HSC-T6 cells. These observations clearly showed that BCL2 down regulation was associated with its promoter methylation and miR-15a/16-1 upregulation in sanguinarine-induced Rat HSC-T6 cells. 2702 miR-15a rno-miR-15a-5p,rno-miR-15a-3p MIMAT0035728,MIMAT0035729 miRNA apoptosis Rattus norvegicus pheochromocytoma cells 20621999 10116 The functional role of miR-15a and miR-16 was investigated in vitro in the rat PC12 pheochromocytoma cell line, and these miRNAs were found to regulate cell proliferation via their effect on cyclin D1 and apoptosis. 2703 miR-16 rno-miR-16-5p,rno-miR-16-3p MIMAT0000785,MIMAT0017094 miRNA apoptosis Rattus norvegicus pheochromocytoma cells 20621999 10116 The functional role of miR-15a and miR-16 was investigated in vitro in the rat PC12 pheochromocytoma cell line, and these miRNAs were found to regulate cell proliferation via their effect on cyclin D2 and apoptosis. 2704 miR-16-1 rno-miR-16-5p,rno-miR-16-3p MIMAT0000785,MIMAT0017094 miRNA Bcl2 apoptosis down Rattus norvegicus HSC-T6 cells 25704029 10116 24224 Bcl-2 RGD:2199|Ensembl:ENSRNOG00000002791 13 13p13 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 BCL2 promotor methylation and miR-15a/16-1 upregulation is associated with sanguinarine-induced apoptotic death in rat HSC-T6 cells. These observations clearly showed that BCL2 down regulation was associated with its promoter methylation and miR-15a/16-1 upregulation in sanguinarine-induced Rat HSC-T6 cells. 2705 miR-181c rno-miR-181c-5p,rno-miR-181c-3p MIMAT0000857,MIMAT0017137 miRNA Tnf apoptosis down Rattus norvegicus microglia cells 22950459 10116 24835 RATTNF|TNF-alpha|Tnfa RGD:3876|Ensembl:ENSRNOG00000000837 20 20p12 tumor necrosis factor protein-coding tumor necrosis factor Overproduction of TNF-¦Á after OGD-induced microglial activation provoked neuronal apoptosis, whereas the ectopic expression of miR-181c partially protected neurons from cell death caused by OGD-activated microglia. 2706 miR-19 rno-miR-19b-1-5p,rno-miR-19b-3p,rno-miR-19b-2-5p,rno-miR-19a-5p,rno-miR-19a-3p MIMAT0017096,MIMAT0000788,MIMAT0017097,MIMAT0017098,MIMAT0000789 miRNA apoptosis Rattus norvegicus gliomas cell 25646654 10116 The results demonstrated that Res inhibited glioma cell proliferation, arrested cell cycle in S?phase and induced apoptosis in?vitro. Res also suppressed intracranial C6 tumor growth in?vivo and prolonged survival in a fraction of the rats bearing intracranial gliomas. Res significantltly downregulated the specific miRs, including miR?21, miR?30a-5p and miR?19, which have been identified as oncomiRs in our previous studies, and altered the expression of their targeting and crucial genes for glioma formation and progression such as p53, PTEN, EGFR, STAT3, COX-2, NF-¦ÊB and PI3K/AKT/mTOR pathway. Therefore, the anti-glioma effect of Res, at least in part, is through the regulation of oncogenic miRNAs. The effect of Res on non-coding RNAs should be studied further. Res is a potential multi-targeting drug for the treatment of gliomas. 2707 miR-193 hsa-miR-193a-5p,hsa-miR-193a-3p,hsa-miR-193b-5p,hsa-miR-193b-3p MIMAT0004614,MIMAT0000459,MIMAT0004767,MIMAT0002819 miRNA Kit apoptosis Rattus norvegicus 24462979 10116 64030 - RGD:620568|Ensembl:ENSRNOG00000002227 14 14p11 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog protein-coding v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog Transmission electron microscopy and TUNEL assay confirmed the increase of follicle apoptosis as Cd concentration increased. Real-time quantitative PCR and Western blotting showed a significantly decreased expression of follicle development-related factors, stem cell factor (SCF) and c-kit. Real-time quantitative PCR revealed a significantly increased expression of miR-193, miR-221 and miR-222, which regulate c-kit, in the 2.0 mg/kg and 8.0 mg/kg treatment groups. 2708 miR-200b rno-miR-200b-3p,rno-miR-200b-5p MIMAT0000875,MIMAT0017152 miRNA Tnfsf10 apoptosis down Rattus norvegicus thyroid cells 23543665 10116 246775 Trail RGD:628734|Ensembl:ENSRNOG00000013269 2 2q24 tumor necrosis factor (ligand) superfamily, member 10 protein-coding tumor necrosis factor (ligand) superfamily, member 10 Up-regulation of miR-146b and Down-regulation of miR-200b Contribute to the Cytotoxic Effect of Histone Deacetylase Inhibitors on ras-Transformed Thyroid Cells.The stabilization of TNF-related apoptosis-inducing ligand (TRAIL) protein, due to its reduced ubiquitination and proteasome degradation 2709 miR-200c rno-miR-200c-3p,rno-miR-200c-5p MIMAT0000873,MIMAT0017150 miRNA Prl apoptosis down Rattus norvegicus pituitary tumor cells 23317100 10116 24683 PRLB|PRLSD1|Prl1a1|Prol|RATPRLSD1|RNPROL RGD:3403|Ensembl:ENSRNOG00000017374 17 17p12 prolactin protein-coding prolactin Additionally, miR-200c was upregulated in MMQ cells compared with RPCs, and downregulation of miR- 200c was observed in SZ-685C-treated MMQ cells.Furthermore, the overexpression of miR-200c weakened the effect of SZ-685C-induced apoptosis of MMQ cells. 2710 miR-203 rno-miR-203a-3p,rno-miR-203a-5p,rno-miR-203b-3p,rno-miR-203b-5p MIMAT0000876,MIMAT0017153,MIMAT0017800,MIMAT0017799 miRNA Pik3r1 apoptosis down Rattus norvegicus mesenchymal stem cell 24659565 10116 25513 PI3KA RGD:3329|Ensembl:ENSRNOG00000018903 2 2q12 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) protein-coding phosphoinositide-3-kinase, regulatory subunit 1 (alpha) In this study, we revealed that rno-miR-203 suppressed activity and colony formation and enhanced apoptosis of the rat bone marrow-derived MSCs (BM-MSCs). Using bioinformatics analysis, we found a potential miR-203 binding site within rat phosphatidylinositol 3-kinase (PI3K) 3'UTR, and fluorescent reporter experiments validated the direct and negative regulation of PI3K expression by miR-203 through this site. 2711 miR-204 rno-miR-204-5p,rno-miR-204-3p MIMAT0000877,MIMAT0004739 miRNA Nrn1 apoptosis down Rattus norvegicus Schwann cell 25036738 10116 83834 Nrn RGD:621586 17 - neuritin 1 protein-coding neuritin 1 MiR-204 promotes apoptosis in oxidative stress-induced rat Schwann cells by suppressing neuritin expression. 2712 miR-21 mmu-miR-21-5p,mmu-miR-21-3p MIMAT0000530,MIMAT0004628 miRNA Faslg apoptosis down Rattus norvegicus cardiomyocytes 20404348 10116 25385 Apt1Lg1|CD95-L|Fasl|Tnfsf6 RGD:3880|Ensembl:ENSRNOG00000002978 13 13q22 Fas ligand (TNF superfamily, member 6) protein-coding Fas ligand (TNF superfamily, member 6) Apoptosis (APO-1) antigen MicroRNA-21 is a downstream effector of AKT that mediates its antiapoptotic effects via suppression of Fas ligand. 2713 miR-21 rno-miR-21-5p,rno-miR-21-3p MIMAT0000790,MIMAT0004711 miRNA Faslg apoptosis down Rattus norvegicus spinal cord cells 23647386 10116 25385 Apt1Lg1|CD95-L|Fasl|Tnfsf6 RGD:3880|Ensembl:ENSRNOG00000002978 13 13q22 Fas ligand (TNF superfamily, member 6) protein-coding Fas ligand (TNF superfamily, member 6) Anti-apoptotic Effect of MicroRNA-21 after Contusion Spinal Cord Injury in Rats. Compared with a negative control group, treatment with antagomir-21 significantly increased apoptosis following SCI. Pro-apoptosis genes FasL, PTEN and PDCD4 were proved to be direct targets of miR-21 in many diseases and cell types. 2714 miR-21 rno-miR-21-5p,rno-miR-21-3p MIMAT0000790,MIMAT0004711 miRNA Pdcd4 apoptosis down Rattus norvegicus cardiomyocytes 20219857 10116 64031 Dug RGD:620816|Ensembl:ENSRNOG00000014779 1 1q55 programmed cell death 4 protein-coding programmed cell death 4 death up-regulated gene p Ischaemic preconditioning-regulated miR-21 protects heart against ischaemia/reperfusion injury via anti-apoptosis through its target PDCD4. 2715 miR-21 rno-miR-21-5p,rno-miR-21-3p MIMAT0000790,MIMAT0004711 miRNA Pdcd4 apoptosis down Rattus norvegicus spinal cord cells 23647386 10116 64031 Dug RGD:620816|Ensembl:ENSRNOG00000014779 1 1q55 programmed cell death 4 protein-coding programmed cell death 4 Anti-apoptotic Effect of MicroRNA-21 after Contusion Spinal Cord Injury in Rats.Compared with a negative control group, treatment with antagomir-21 significantly increased apoptosis following SCI. Pro-apoptosis genes FasL, PTEN and PDCD4 were proved to be direct targets of miR-21 in many diseases and cell types. 2716 miR-21 rno-miR-21-5p,rno-miR-21-3p MIMAT0000790,MIMAT0004711 miRNA Pten apoptosis down Rattus norvegicus spinal cord cells 23647386 10116 50557 MMAC1|Mmac|TEP1 RGD:61995|Ensembl:ENSRNOG00000020723 1 1q41-q43 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog Anti-apoptotic Effect of MicroRNA-21 after Contusion Spinal Cord Injury in Rats.Compared with a negative control group, treatment with antagomir-21 significantly increased apoptosis following SCI. Pro-apoptosis genes FasL, PTEN and PDCD4 were proved to be direct targets of miR-21 in many diseases and cell types. 2717 miR-21 rno-miR-21-5p,rno-miR-21-3p MIMAT0000790,MIMAT0004711 miRNA apoptosis Rattus norvegicus heart cell 19706597 10116 The protective effect of miR-21 against ischemia-induced cardiac myocyte damage was further confirmed in vivo by decreased cell apoptosis in the border and infarcted areas of the infarcted rat hearts after treatment with Ad-miR-21. The results suggest that miRNAs such as miR-21 may play critical roles in the early phase of AMI. 2718 miR-21 rno-miR-21-5p,rno-miR-21-3p MIMAT0000790,MIMAT0004711 miRNA apoptosis Rattus norvegicus gliomas cell 25646654 10116 The results demonstrated that Res inhibited glioma cell proliferation, arrested cell cycle in S?phase and induced apoptosis in?vitro. Res also suppressed intracranial C6 tumor growth in?vivo and prolonged survival in a fraction of the rats bearing intracranial gliomas. Res significantltly downregulated the specific miRs, including miR?21, miR?30a-5p and miR?19, which have been identified as oncomiRs in our previous studies, and altered the expression of their targeting and crucial genes for glioma formation and progression such as p53, PTEN, EGFR, STAT3, COX-2, NF-¦ÊB and PI3K/AKT/mTOR pathway. Therefore, the anti-glioma effect of Res, at least in part, is through the regulation of oncogenic miRNAs. The effect of Res on non-coding RNAs should be studied further. Res is a potential multi-targeting drug for the treatment of gliomas. 2719 miR-214 rno-miR-214-3p,rno-miR-214-5p MIMAT0000885,MIMAT0017159 miRNA Prdx6 apoptosis down Rattus norvegicus skin 24447893 10116 94167 - RGD:71005|Ensembl:ENSRNOG00000002896 13 13q22 peroxiredoxin 6 protein-coding peroxiredoxin 6 PRDX-6 is suppressed by radiation-inducible miR-214 and is involved in the pathogenesis of radiation-induced skin injury. 2720 miR-221 rno-miR-221-5p,rno-miR-221-3p MIMAT0017163,MIMAT0000890 miRNA Apaf1 apoptosis down Rattus norvegicus pheochromocytoma cells 22465943 10116 78963 - RGD:620575|Ensembl:ENSRNOG00000008022 7 7q13 apoptotic peptidase activating factor 1 protein-coding apoptotic peptidase activating factor 1 apaf-1|apoptotic protease Finally, miR-221 decreased expression of Foxo3a and Apaf-1, both of which are known to be involved in apoptosis in PC12 cells. 2721 miR-221 rno-miR-221-5p,rno-miR-221-3p MIMAT0017163,MIMAT0000890 miRNA Cdkn1b apoptosis down Rattus norvegicus vascular smooth muscle cells 22138289 10116 83571 CDKN4|Cdki1b|Kip1|P27KIP1|p27 RGD:69062|Ensembl:ENSRNOG00000007249 4 4q43 cyclin-dependent kinase inhibitor 1B protein-coding cyclin-dependent kinase inhibitor 1B Cyclin-dependent kinase i In VSMCs, miR-221/222 had effects of pro-proliferation, pro-migration, and anti-apoptosis. In contrast, miR-221/222 had effects of anti-proliferation, anti-migration, and pro-apoptosis in ECs. The different expression profiles of their target genes, p27(Kip1), p57(kip2), and c-kit between the two cell types might be related to the opposite effects 2722 miR-221 rno-miR-221-5p,rno-miR-221-3p MIMAT0017163,MIMAT0000890 miRNA Cdkn1c apoptosis down Rattus norvegicus vascular smooth muscle cells 22138289 10116 246060 Kip2|p57|p57KIP2 RGD:727892 1 1q42 cyclin-dependent kinase inhibitor 1C protein-coding cyclin-dependent kinase inhibitor 1C cyclin-dependent kinase i In VSMCs, miR-221/222 had effects of pro-proliferation, pro-migration, and anti-apoptosis. In contrast, miR-221/222 had effects of anti-proliferation, anti-migration, and pro-apoptosis in ECs. The different expression profiles of their target genes, p27(Kip1), p57(kip2), and c-kit between the two cell types might be related to the opposite effects 2723 miR-221 rno-miR-221-5p,rno-miR-221-3p MIMAT0017163,MIMAT0000890 miRNA Foxo3 apoptosis down Rattus norvegicus pheochromocytoma cells 22465943 10116 294515 Fkhrl1|Foxo3a RGD:1309196|Ensembl:ENSRNOG00000000299 20 20q13 forkhead box O3 protein-coding forkhead box O3 Finally, miR-221 decreased expression of Foxo3a and Apaf-1, both of which are known to be involved in apoptosis in PC12 cells. 2724 miR-221 rno-miR-221-5p,rno-miR-221-3p MIMAT0017163,MIMAT0000890 miRNA Kit apoptosis down Rattus norvegicus vascular smooth muscle cells 22138289 10116 64030 - RGD:620568|Ensembl:ENSRNOG00000002227 14 14p11 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog protein-coding v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog c-kit receptor tyrosine k In VSMCs, miR-221/222 had effects of pro-proliferation, pro-migration, and anti-apoptosis. In contrast, miR-221/222 had effects of anti-proliferation, anti-migration, and pro-apoptosis in ECs. The different expression profiles of their target genes, p27(Kip1), p57(kip2), and c-kit between the two cell types might be related to the opposite effects 2725 miR-221 rno-miR-221-5p,rno-miR-221-3p MIMAT0017163,rno-miR-221-3p miRNA Kit apoptosis Rattus norvegicus 24462979 10116 64030 - RGD:620568|Ensembl:ENSRNOG00000002227 14 14p11 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog protein-coding v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog Transmission electron microscopy and TUNEL assay confirmed the increase of follicle apoptosis as Cd concentration increased. Real-time quantitative PCR and Western blotting showed a significantly decreased expression of follicle development-related factors, stem cell factor (SCF) and c-kit. Real-time quantitative PCR revealed a significantly increased expression of miR-193, miR-221 and miR-222, which regulate c-kit, in the 2.0 mg/kg and 8.0 mg/kg treatment groups. 2726 miR-222 rno-miR-222-5p,rno-miR-222-3p MIMAT0017164,MIMAT0000891 miRNA Cdkn1b apoptosis down Rattus norvegicus vascular smooth muscle cells 22138289 10116 83571 CDKN4|Cdki1b|Kip1|P27KIP1|p27 RGD:69062|Ensembl:ENSRNOG00000007249 4 4q43 cyclin-dependent kinase inhibitor 1B protein-coding cyclin-dependent kinase inhibitor 1B Cyclin-dependent kinase i In VSMCs, miR-221/222 had effects of pro-proliferation, pro-migration, and anti-apoptosis. In contrast, miR-221/222 had effects of anti-proliferation, anti-migration, and pro-apoptosis in ECs. The different expression profiles of their target genes, p27(Kip1), p57(kip2), and c-kit between the two cell types might be related to the opposite effects 2727 miR-222 rno-miR-222-5p,rno-miR-222-3p MIMAT0017164,MIMAT0000891 miRNA Cdkn1c apoptosis down Rattus norvegicus vascular smooth muscle cells 22138289 10116 246060 Kip2|p57|p57KIP2 RGD:727892 1 1q42 cyclin-dependent kinase inhibitor 1C protein-coding cyclin-dependent kinase inhibitor 1C cyclin-dependent kinase i In VSMCs, miR-221/222 had effects of pro-proliferation, pro-migration, and anti-apoptosis. In contrast, miR-221/222 had effects of anti-proliferation, anti-migration, and pro-apoptosis in ECs. The different expression profiles of their target genes, p27(Kip1), p57(kip2), and c-kit between the two cell types might be related to the opposite effects 2728 miR-222 rno-miR-222-5p,rno-miR-222-3p MIMAT0017164,MIMAT0000891 miRNA Kit apoptosis down Rattus norvegicus vascular smooth muscle cells 22138289 10116 64030 - RGD:620568|Ensembl:ENSRNOG00000002227 14 14p11 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog protein-coding v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog c-kit receptor tyrosine k In VSMCs, miR-221/222 had effects of pro-proliferation, pro-migration, and anti-apoptosis. In contrast, miR-221/222 had effects of anti-proliferation, anti-migration, and pro-apoptosis in ECs. The different expression profiles of their target genes, p27(Kip1), p57(kip2), and c-kit between the two cell types might be related to the opposite effects 2729 miR-222 rno-miR-222-5p,rno-miR-222-3p MIMAT0017164,MIMAT0000891 miRNA Kit apoptosis Rattus norvegicus 24462979 10116 64030 - RGD:620568|Ensembl:ENSRNOG00000002227 14 14p11 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog protein-coding v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog Transmission electron microscopy and TUNEL assay confirmed the increase of follicle apoptosis as Cd concentration increased. Real-time quantitative PCR and Western blotting showed a significantly decreased expression of follicle development-related factors, stem cell factor (SCF) and c-kit. Real-time quantitative PCR revealed a significantly increased expression of miR-193, miR-221 and miR-222, which regulate c-kit, in the 2.0 mg/kg and 8.0 mg/kg treatment groups. 2730 miR-223 rno-miR-223-3p,rno-miR-223-5p MIMAT0017165,MIMAT0000892 miRNA Bax apoptosis down Rattus norvegicus 25416533 10116 24887 - RGD:2192|Ensembl:ENSRNOG00000020876 1 1q31.2 Bcl2-associated X protein protein-coding Bcl2-associated X protein Additionally, antagomir-223 treatment markedly decreased the pro-apoptotic protein levels, including Bax and cleaved caspase-3, up-regulated the anti-apoptotic Bcl-2 protein level, as well as the expression of GluR2. 2731 miR-223 rno-miR-223-3p,rno-miR-223-5p MIMAT0017165,MIMAT0000892 miRNA Bcl2 apoptosis down Rattus norvegicus 25416533 10116 24224 Bcl-2 RGD:2199|Ensembl:ENSRNOG00000002791 13 13p13 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 Additionally, antagomir-223 treatment markedly decreased the pro-apoptotic protein levels, including Bax and cleaved caspase-3, up-regulated the anti-apoptotic Bcl-2 protein level, as well as the expression of GluR2. 2732 miR-223 rno-miR-223-3p,rno-miR-223-5p MIMAT0017165,MIMAT0000892 miRNA Casp3 apoptosis down Rattus norvegicus 25416533 10116 25402 Lice RGD:2275|Ensembl:ENSRNOG00000010475 16 16q11 caspase 3 protein-coding caspase 3 Additionally, antagomir-223 treatment markedly decreased the pro-apoptotic protein levels, including Bax and cleaved caspase-3, up-regulated the anti-apoptotic Bcl-2 protein level, as well as the expression of GluR2. 2733 miR-223 rno-miR-223-3p,rno-miR-223-5p MIMAT0017165,MIMAT0000892 miRNA Gria2 apoptosis up Rattus norvegicus 25416533 10116 29627 GluA2|GluR-K2|GluR2|gluR-B RGD:61862|Ensembl:ENSRNOG00000028589 2 2q33 glutamate receptor, ionotropic, AMPA 2 protein-coding glutamate receptor, ionotropic, AMPA 2 Additionally, antagomir-223 treatment markedly decreased the pro-apoptotic protein levels, including Bax and cleaved caspase-3, up-regulated the anti-apoptotic Bcl-2 protein level, as well as the expression of GluR2. 2734 miR-29a rno-miR-29a-3p,rno-miR-29a-5p MIMAT0000802,MIMAT0004718 miRNA Bak1 apoptosis down Rattus norvegicus uterus 24528955 10116 116502 - RGD:621635|Ensembl:ENSRNOG00000000485 20 20p12 BCL2-antagonist/killer 1 protein-coding BCL2-antagonist/killer 1 Further investigation revealed that both the pro-apoptotic factor genes Bak1 and Bmf and the anti-apoptotic factor gene Bcl-w are targets of miR-29a 2735 miR-29a rno-miR-29a-3p,rno-miR-29a-5p MIMAT0000802,MIMAT0004718 miRNA Bcl2l2 apoptosis up Rattus norvegicus uterus 24528955 10116 60434 BCL-W|BCL-WEL|BCL-WS|Bclw RGD:620717|Ensembl:ENSRNOG00000015732 15 15p13 Bcl2-like 2 protein-coding Bcl2-like 2 Further investigation revealed that both the pro-apoptotic factor genes Bak1 and Bmf and the anti-apoptotic factor gene Bcl-w are targets of miR-29a. 2736 miR-29a rno-miR-29a-3p,rno-miR-29a-5p MIMAT0000802,MIMAT0004718 miRNA Bmf apoptosis down Rattus norvegicus uterus 24528955 10116 246142 - RGD:628658|Ensembl:ENSRNOG00000007529 3 3q35 Bcl2 modifying factor protein-coding Bcl2 modifying factor Further investigation revealed that both the pro-apoptotic factor genes Bak1 and Bmf and the anti-apoptotic factor gene Bcl-w are targets of miR-29a. 2737 miR-29c rno-miR-29c-3p MIMAT0000803 miRNA Bak1 apoptosis down Rattus norvegicus brain 25678279 10116 116502 - RGD:621635|Ensembl:ENSRNOG00000000485 20 20p12 BCL2-antagonist/killer 1 protein-coding BCL2-antagonist/killer 1 BCL2-antagonist/killer 1 Furthermore, over-expression of miR-29c effectively reduced Birc2 (also Bak1) mRNA and protein levels, increased infarct volume and apoptosis, and deteriorated neurological outcomes, whereas down-regulation played a neuroprotective role. 2738 miR-29c rno-miR-29c-3p MIMAT0000803 miRNA Birc2 apoptosis down Rattus norvegicus brain 25678279 10116 60371 Api2|rIAP1 RGD:620690|Ensembl:ENSRNOG00000010602 8 8q11 baculoviral IAP repeat-containing 2 protein-coding baculoviral IAP repeat-containing 2 baculoviral IAP repeat-containing 2 Furthermore, over-expression of miR-29c effectively reduced Birc2 (also Bak1) mRNA and protein levels, increased infarct volume and apoptosis, and deteriorated neurological outcomes, whereas down-regulation played a neuroprotective role. 2739 miR-30a-5p rno-miR-30a-5p MIMAT0000808 miRNA apoptosis Rattus norvegicus gliomas cell 25646654 10116 The results demonstrated that Res inhibited glioma cell proliferation, arrested cell cycle in S?phase and induced apoptosis in?vitro. Res also suppressed intracranial C6 tumor growth in?vivo and prolonged survival in a fraction of the rats bearing intracranial gliomas. Res significantltly downregulated the specific miRs, including miR?21, miR?30a-5p and miR?19, which have been identified as oncomiRs in our previous studies, and altered the expression of their targeting and crucial genes for glioma formation and progression such as p53, PTEN, EGFR, STAT3, COX-2, NF-¦ÊB and PI3K/AKT/mTOR pathway. Therefore, the anti-glioma effect of Res, at least in part, is through the regulation of oncogenic miRNAs. The effect of Res on non-coding RNAs should be studied further. Res is a potential multi-targeting drug for the treatment of gliomas. 2740 miR-30b rno-miR-30b-5p MIMAT0000806 miRNA Akt1 apoptosis up Rattus norvegicus H9C2 cells 25701595 10116 24185 Akt RGD:2081|Ensembl:ENSRNOG00000028629 6 6q32 v-akt murine thymoma viral oncogene homolog 1 protein-coding v-akt murine thymoma viral oncogene homolog 1 v-akt murine thymoma viral oncogene homolog 1 In conclusion, the H/R induced apoptosis decreased miR-30b expression, but over-expression of miR-30b inhibited H/R induced apoptosis.Western blot analysis revealed that overexpression of miR-30b mimic resulted in significantly increase in AKT activation and decreased KRAS, compared to the H/R+VC group (both P<0.05). 2741 miR-30b rno-miR-30b-5p MIMAT0000806 miRNA Kras apoptosis down Rattus norvegicus H9C2 cells 25701595 10116 24525 Kras2|c-Ki-ras|p21 RGD:2981|Ensembl:ENSRNOG00000009338 4 4q44 Kirsten rat sarcoma viral oncogene protein-coding Kirsten rat sarcoma viral oncogene Kirsten rat sarcoma viral oncogene In conclusion, the H/R induced apoptosis decreased miR-30b expression, but over-expression of miR-30b inhibited H/R induced apoptosis.Western blot analysis revealed that overexpression of miR-30b mimic resulted in significantly increase in AKT activation and decreased KRAS, compared to the H/R+VC group (both P<0.05). 2742 miR-320 rno-miR-320-5p,rno-miR-320-3p MIMAT0017168,MIMAT0000903 miRNA apoptosis Rattus norvegicus myocardial cell 25268616 10116 Tissues samples in both the sham and I/R+antagomir-320 groups showed a lower apoptosis rate compared to I/R group. The qRT-PCR results indicated that miR-320 expression in the I/R group was significantly higher than that in both the sham and I/R+antagomir-320 groups. The expression level of miR-320 is significantly up-regulated in the rat model of myocardial I/R injury, and it may be implicated in the prevention of myocardial I/R injury-triggered left ventricular remodeling. 2743 miR-322 rno-miR-322-5p,rno-miR-322-3p MIMAT0000547,MIMAT0001619 miRNA Calu apoptosis down Rattus norvegicus smooth muscle cell 23447642 10116 64366 Cbp50|Rcn RGD:620383|Ensembl:ENSRNOG00000006197 4 4q22 calumenin protein-coding calumenin MiR-424/322 overexpression in vitro inhibited proliferation and migration without affecting apoptosis and prevented VSMC dedifferentiation. Furthermore, miR-424/322 overexpression resulted in decreased expression of its predicted targets: cyclin D1 and Ca(2+)-regulating proteins calumenin and stromal-interacting molecule 1 (STIM1). Using reporter luciferase assays, we confirmed that cyclin D1 and calumenin mRNAs were direct targets of miR-322, whereas miR-322 effect on STIM1 was indirect. 2744 miR-322 rno-miR-322-5p,rno-miR-322-3p MIMAT0000547,MIMAT0001619 miRNA Ccnd1 apoptosis Rattus norvegicus smooth muscle cell 23447642 10116 58919 - RGD:68384|Ensembl:ENSRNOG00000020918 1 1q42 cyclin D1 protein-coding cyclin D1 MiR-424/322 overexpression in vitro inhibited proliferation and migration without affecting apoptosis and prevented VSMC dedifferentiation. Furthermore, miR-424/322 overexpression resulted in decreased expression of its predicted targets: cyclin D1 and Ca(2+)-regulating proteins calumenin and stromal-interacting molecule 1 (STIM1). Using reporter luciferase assays, we confirmed that cyclin D1 and calumenin mRNAs were direct targets of miR-322, whereas miR-322 effect on STIM1 was indirect. 2745 miR-335 rno-miR-335 MIMAT0000575 miRNA Rasa1 apoptosis down Rattus norvegicus epididymal cell 20933506 10116 25676 GAPX|Rasa RGD:3537|Ensembl:ENSRNOG00000029185 2 2q11 RAS p21 protein activator (GTPase activating protein) 1 protein-coding RAS p21 protein activator (GTPase activating protein) 1 The bioinformatic analysis indicated that one of miR-335's putative targets is RASA1, a known gene related to cell proliferation and anti-apoptosis, which may contribute to the epididymal development. It was found that the overexpression of miR-335 in NIH/3T3 cells caused the suppression of RASA1 expression. 2746 miR-34a rno-miR-34a-3p,rno-miR-34a-5p MIMAT0017106,MIMAT0000815 miRNA Casp3 apoptosis down Rattus norvegicus hippocampal neurone cells 22998082 10116 25402 Lice RGD:2275|Ensembl:ENSRNOG00000010475 16 16q11 caspase 3 protein-coding caspase 3 Experi ments with the miR-34a antagomir revealed that targeting miR-34a led to an inhibition of activated caspase-3 protein expression, which may contribute to increased neuronal survival and reduced neuronal death or apoptosis. 2747 miR-34a rno-miR-34a-5p,rno-miR-34a-3p MIMAT0000815,MIMAT0017106 miRNA Col2a1 apoptosis up Rattus norvegicus osteoarthritis cell 20675358 10116 25412 CG2A1A|COLLII RGD:2375|Ensembl:ENSRNOG00000022282 7 7q36 collagen, type II, alpha 1 protein-coding collagen, type II, alpha 1 The expression of miR-34a was significantly up-regulated by IL-1¦Â. Silencing of miR-34a significantly prevented IL-1¦Â-induced down-regulation of Col2a1, as well as IL-1¦Â-induced up-regulation of iNOS. Finally, MiR-34a inhibitor could also reduce TUNEL-positive cells. 2748 miR-34a rno-miR-34a-5p,rno-miR-34a-3p MIMAT0000815,MIMAT0017106 miRNA Il1b apoptosis Rattus norvegicus osteoarthritis cell 20675358 10116 24494 - RGD:2891|Ensembl:ENSRNOG00000004649 3 3q36 interleukin 1 beta protein-coding interleukin 1 beta The expression of miR-34a was significantly up-regulated by IL-1¦Â. Silencing of miR-34a significantly prevented IL-1¦Â-induced down-regulation of Col2a1, as well as IL-1¦Â-induced up-regulation of iNOS. Finally, MiR-34a inhibitor could also reduce TUNEL-positive cells. 2749 miR-34a rno-miR-34a-5p,rno-miR-34a-3p MIMAT0000815,MIMAT0017106 miRNA Nos2 apoptosis down Rattus norvegicus osteoarthritis cell 20675358 10116 24599 Nos2a|iNos RGD:3185|Ensembl:ENSRNOG00000049980 10 10q25 nitric oxide synthase 2, inducible protein-coding nitric oxide synthase 2, inducible The expression of miR-34a was significantly up-regulated by IL-1¦Â. Silencing of miR-34a significantly prevented IL-1¦Â-induced down-regulation of Col2a1, as well as IL-1¦Â-induced up-regulation of iNOS. Finally, MiR-34a inhibitor could also reduce TUNEL-positive cells. 2750 miR-34a rno-miR-34a-5p,rno-miR-34a-3p MIMAT0000815,MIMAT0017106 miRNA Sirt1 apoptosis down Rattus norvegicus liver 24421392 10116 309757 Sir2 RGD:1308542 20 20p11 sirtuin 1 protein-coding sirtuin 1 miR-34a inhibition and SIRT1 overexpression significantly rescued targeting of the miR-34a pathway and apoptosis by DCA. 2751 miR-34a rno-miR-34a-5p,rno-miR-34a-3p MIMAT0000815,MIMAT0017106 miRNA apoptosis Rattus norvegicus liver cells 22902550 10116 miR-34a overexpression confirmed its targeting by UDCA, which prevented miR-34a-dependent repression of SIRT1, p53 acetylation, and apoptosis. 2752 miR-350 rno-miR-350 MIMAT0000604 miRNA Mapk14 apoptosis down Rattus norvegicus cardiomyocyte 23000971 10116 81649 CRK1|CSBP|CSPB1|Csbp1|Csbp2|Exip|Hog|Mxi2|Prkm14|Prkm15|RK|Sapk2A|p38|p38Hog|p38alpha RGD:70496|Ensembl:ENSRNOG00000000513 20 20p12 mitogen activated protein kinase 14 protein-coding mitogen activated protein kinase 14 Western blotting and luciferase assays confirmed that the target mRNAs of miR-350 are mitogen activated protein kinase (MAPK) 11/14 and MAPK8/9 gene transcripts. 2753 miR-350 rno-miR-350 MIMAT0000604 miRNA Mapk8 apoptosis down Rattus norvegicus cardiomyocyte 23000971 10116 116554 JNK RGD:621506 16 16p16 mitogen-activated protein kinase 8 protein-coding mitogen-activated protein kinase 8 Western blotting and luciferase assays confirmed that the target mRNAs of miR-350 are mitogen activated protein kinase (MAPK) 11/14 and MAPK8/9 gene transcripts. 2754 miR-365 miRNA Ccnd1 apoptosis down Rattus norvegicus VSMCs 24936138 10116 58919 - RGD:68384|Ensembl:ENSRNOG00000020918 1 1q42 cyclin D1 protein-coding cyclin D1 MicroRNA-365 (miR-365) plays crucial roles in regulating cell proliferation, apoptosis and differentiation in various cell types. However, its function in vascular smooth muscle cells (VSMCs) is largely unknown. In our study, we found miR-365 was highly expressed in adult rat carotid arteries, but was significantly decreased in rat carotid arteries after balloon injury, a process involving neointima formation and VSMC proliferation. In vitro, the miR-365 significantly inhibited cell proliferation of isolated primary rat aortic VSMCs. Furthermore, we identified that cyclin D1 was a direct target of miR-365 in VSMCs. 2755 miR-370 rno-miR-370-3p,rno-miR-370-5p MIMAT0003122,MIMAT0017202 miRNA Smo apoptosis down Rattus norvegicus fibrotic liver cell 25686745 10116 25273 Smoh RGD:3726|Ensembl:ENSRNOG00000008332 4 4q22 smoothened, frizzled class receptor protein-coding smoothened, frizzled class receptor Real-time PCR showed that miR-370 expression was significantly reduced in rat fibrotic livers and TGF¦Â1-stimulated HSCs. Overexpression of miR-370 inhibited the proliferation of HSC-T6 cells via inducing cell apoptosis and suppressed the activation of HSCs. Upregulation of miR-370 obviously attenuated the CCl4-induced liver fibrosis in rats. miR-370 was directly bound to the 3'UTR of Smoothened (SMO) and suppressed the expression of SMO in HSCs and fibrotic livers. 2756 miR-384-5p rno-miR-384-5p MIMAT0005309 miRNA Casp3 apoptosis up Rattus norvegicus myocardial 23315007 10116 25402 Lice RGD:2275|Ensembl:ENSRNOG00000010475 16 16q11 caspase 3 protein-coding caspase 3 In addition, bioinformatics analyses, such as Gene ontology and Pathway assays, were applied to determine the apoptosis pathway, only regulated by miR-384-5p, and all the associated target genes (PIK3CD, PPP3CA, PPP3CB, PPP3R1, CASP3 and IL1A). These target genes, besides PIK3CB, were shown to be significantly up-regulated by qRT-PCR assay, which further suggested that PIK3CD, PPP3CA, PPP3R1, CASP3, IL1A could be regulated by miR-384-5p. 2757 miR-384-5p rno-miR-384-5p MIMAT0005309 miRNA Il1a apoptosis down Rattus norvegicus myocardial 23315007 10116 24493 IL-1 alpha RGD:2890 3 3q36 interleukin 1 alpha protein-coding interleukin 1 alpha In addition, bioinformatics analyses, such as Gene ontology and Pathway assays, were applied to determine the apoptosis pathway, only regulated by miR-384-5p, and all the associated target genes (PIK3CD, PPP3CA, PPP3CB, PPP3R1, CASP3 and IL1A). These target genes, besides PIK3CB, were shown to be significantly up-regulated by qRT-PCR assay, which further suggested that PIK3CD, PPP3CA, PPP3R1, CASP3, IL1A could be regulated by miR-384-5p. 2758 miR-384-5p rno-miR-384-5p MIMAT0005309 miRNA Pik3cd apoptosis down Rattus norvegicus myocardial 23315007 10116 366508 - RGD:1310990|Ensembl:ENSRNOG00000016846 5 5q36 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta protein-coding phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta In addition, bioinformatics analyses, such as Gene ontology and Pathway assays, were applied to determine the apoptosis pathway, only regulated by miR-384-5p, and all the associated target genes (PIK3CD, PPP3CA, PPP3CB, PPP3R1, CASP3 and IL1A). These target genes, besides PIK3CB, were shown to be significantly up-regulated by qRT-PCR assay, which further suggested that PIK3CD, PPP3CA, PPP3R1, CASP3, IL1A could be regulated by miR-384-5p. 2759 miR-384-5p rno-miR-384-5p MIMAT0005309 miRNA Ppp3ca apoptosis down Rattus norvegicus myocardial 23315007 10116 24674 Calna1 RGD:3382|Ensembl:ENSRNOG00000009882 2 2q43 protein phosphatase 3, catalytic subunit, alpha isozyme protein-coding protein phosphatase 3, catalytic subunit, alpha isozyme In addition, bioinformatics analyses, such as Gene ontology and Pathway assays, were applied to determine the apoptosis pathway, only regulated by miR-384-5p, and all the associated target genes (PIK3CD, PPP3CA, PPP3CB, PPP3R1, CASP3 and IL1A). These target genes, besides PIK3CB, were shown to be significantly up-regulated by qRT-PCR assay, which further suggested that PIK3CD, PPP3CA, PPP3R1, CASP3, IL1A could be regulated by miR-384-5p. 2760 miR-384-5p rno-miR-384-5p MIMAT0005309 miRNA Ppp3r1 apoptosis down Rattus norvegicus myocardial 23315007 10116 29748 - RGD:69230|Ensembl:ENSRNOG00000043210 14 14q22 protein phosphatase 3, regulatory subunit B, alpha protein-coding protein phosphatase 3, regulatory subunit B, alpha In addition, bioinformatics analyses, such as Gene ontology and Pathway assays, were applied to determine the apoptosis pathway, only regulated by miR-384-5p, and all the associated target genes (PIK3CD, PPP3CA, PPP3CB, PPP3R1, CASP3 and IL1A). These target genes, besides PIK3CB, were shown to be significantly up-regulated by qRT-PCR assay, which further suggested that PIK3CD, PPP3CA, PPP3R1, CASP3, IL1A could be regulated by miR-384-5p. 2761 let-7 rno-let-7a-1-3p,rno-let-7a-2-3p,rno-let-7a-5p,rno-let-7b-3p,rno-let-7b-5p,rno-let-7c-1-3p,rno-let-7c-2-3p,rno-let-7c-5p,rno-let-7d-3p,rno-let-7d-5p,rno-let-7e-3p,rno-let-7e-5p,rno-let-7f-1-3p,rno-let-7f-2-3p,rno-let-7f-5p,rno-let-7g-3p,rno-let-7g-5p,rno-let-7i-3p,rno-let-7i-5p MIMAT0017085,MIMAT0017086,MIMAT0000774,MIMAT0004705,MIMAT0000775,MIMAT0017087,MIMAT0017088,MIMAT0000776,MIMAT0000563,MIMAT0000562,MIMAT0004706,MIMAT0000777,MIMAT0017089,MIMAT0017090,MIMAT0000778,MIMAT0035720,MIMAT0035719,MIMAT0004707,MIMAT0000779 miRNA apoptosis Rattus norvegicus lungs 18952709 10116 The most remarkably down-regulated microRNAs belonged to the families of let-7, miR-10, miR-26, miR-30, miR-34, miR-99, miR-122, miR-123, miR-124, miR-125, miR-140, miR-145, miR-146, miR-191, miR-192, miR-219, miR-222, and miR-223, which regulate stress response, apoptosis, proliferation, angiogenesis, and expression of genes. 2762 miR-1 rno-miR-1-5p,rno-miR-1-3p MIMAT0003162,MIMAT0003125 miRNA Casp9 apoptosis Rattus norvegicus cardiomyocytes 17715156 10116 58918 Apaf3|Casp-9-CTD|Casp9_v1|Ice-Lap6|Mch6 RGD:61867|Ensembl:ENSRNOG00000012944 5 5q36 caspase 9, apoptosis-related cysteine peptidase protein-coding caspase 9, apoptosis-related cysteine peptidase The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60, HSP70 and caspase-9 in cardiomyocytes. 2763 miR-1 rno-miR-1-5p,rno-miR-1-3p MIMAT0003162,MIMAT0003125 miRNA Hspa4 apoptosis Rattus norvegicus cardiomyocytes 17715156 10116 266759 Hsp110|Hsp70|irp94 RGD:628878|Ensembl:ENSRNOG00000016596 10 10q22 heat shock protein 4 protein-coding heat shock protein 4 The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60, HSP70 and caspase-9 in cardiomyocytes. 2764 miR-1 rno-miR-1-5p,rno-miR-1-3p MIMAT0003162,MIMAT0003125 miRNA Hspd1 apoptosis Rattus norvegicus cardiomyocytes 17715156 10116 63868 Hsp60|Hspd1-30p RGD:621314|Ensembl:ENSRNOG00000014525 9 9q22 heat shock protein 1 (chaperonin) protein-coding heat shock protein 1 (chaperonin) The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60, HSP70 and caspase-9 in cardiomyocytes. 2765 miR-10 rno-miR-10a-5p,rno-miR-10a-3p,rno-miR-10b-5p,rno-miR-10b-3p MIMAT0000782,MIMAT0004709,MIMAT0000782,MIMAT0017092 miRNA apoptosis Rattus norvegicus lungs 18952709 10116 The most remarkably down-regulated microRNAs belonged to the families of let-7, miR-10, miR-26, miR-30, miR-34, miR-99, miR-122, miR-123, miR-124, miR-125, miR-140, miR-145, miR-146, miR-191, miR-192, miR-219, miR-222, and miR-223, which regulate stress response, apoptosis, proliferation, angiogenesis, and expression of genes. 2766 miR-122 rno-miR-122-5p,rno-miR-122-3p MIMAT0000827,MIMAT0017116 miRNA apoptosis Rattus norvegicus lungs 18952709 10116 The most remarkably down-regulated microRNAs belonged to the families of let-7, miR-10, miR-26, miR-30, miR-34, miR-99, miR-122, miR-123, miR-124, miR-125, miR-140, miR-145, miR-146, miR-191, miR-192, miR-219, miR-222, and miR-223, which regulate stress response, apoptosis, proliferation, angiogenesis, and expression of genes. 2767 miR-123 miRNA apoptosis Rattus norvegicus lungs 18952709 10116 The most remarkably down-regulated microRNAs belonged to the families of let-7, miR-10, miR-26, miR-30, miR-34, miR-99, miR-122, miR-123, miR-124, miR-125, miR-140, miR-145, miR-146, miR-191, miR-192, miR-219, miR-222, and miR-223, which regulate stress response, apoptosis, proliferation, angiogenesis, and expression of genes. 2768 miR-124 rno-miR-124-5p,rno-miR-124-3p MIMAT0004728,MIMAT0000828 miRNA apoptosis Rattus norvegicus lungs 18952709 10116 The most remarkably down-regulated microRNAs belonged to the families of let-7, miR-10, miR-26, miR-30, miR-34, miR-99, miR-122, miR-123, miR-124, miR-125, miR-140, miR-145, miR-146, miR-191, miR-192, miR-219, miR-222, and miR-223, which regulate stress response, apoptosis, proliferation, angiogenesis, and expression of genes. 2769 miR-125 rno-miR-125a-5p,rno-miR-125a-3p,rno-miR-125b-5p,rno-miR-125b-1-3p,rno-miR-125b-2-3p MIMAT0000829,MIMAT0004729,MIMAT0000830,MIMAT0004730,MIMAT0026467 miRNA apoptosis Rattus norvegicus lungs 18952709 10116 The most remarkably down-regulated microRNAs belonged to the families of let-7, miR-10, miR-26, miR-30, miR-34, miR-99, miR-122, miR-123, miR-124, miR-125, miR-140, miR-145, miR-146, miR-191, miR-192, miR-219, miR-222, and miR-223, which regulate stress response, apoptosis, proliferation, angiogenesis, and expression of genes. 2770 miR-127 rno-miR-127-5p,rno-miR-127-3p MIMAT0017117,MIMAT0000833 miRNA apoptosis Rattus norvegicus hepatocellular carcinoma 18942116 10116 We showed that the development of hepatocellular carcinoma (HCC) is characterized by prominent early changes in expression of miRNA genes, specifically by inhibition of expression of microRNAs miR-34a, miR-127, miR-200b, and miR-16a involved in the regulation of apoptosis, cell proliferation, cell-to-cell connection, and epithelial-mesenchymal transition. 2771 miR-133 rno-miR-133a-3p,rno-miR-133a-5p,rno-miR-133b-3p,rno-miR-133b-5p,rno-miR-133c MIMAT0000839,MIMAT0003126,MIMAT0017124,MIMAT0017205,MIMAT0017872 miRNA Casp9 apoptosis Rattus norvegicus cardiomyocytes 17715156 10116 58918 Apaf3|Casp-9-CTD|Casp9_v1|Ice-Lap6|Mch6 RGD:61867|Ensembl:ENSRNOG00000012944 5 5q36 caspase 9, apoptosis-related cysteine peptidase protein-coding caspase 9, apoptosis-related cysteine peptidase The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60, HSP70 and caspase-9 in cardiomyocytes. 2772 miR-133 rno-miR-133a-3p,rno-miR-133a-5p,rno-miR-133b-3p,rno-miR-133b-5p,rno-miR-133c MIMAT0000839,MIMAT0003126,MIMAT0017124,MIMAT0017205,MIMAT0017872 miRNA Hspa4 apoptosis Rattus norvegicus cardiomyocytes 17715156 10116 266759 Hsp110|Hsp70|irp94 RGD:628878|Ensembl:ENSRNOG00000016596 10 10q22 heat shock protein 4 protein-coding heat shock protein 4 The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60, HSP70 and caspase-9 in cardiomyocytes. 2773 miR-133 rno-miR-133a-3p,rno-miR-133a-5p,rno-miR-133b-3p,rno-miR-133b-5p,rno-miR-133c MIMAT0000839,MIMAT0003126,MIMAT0017124,MIMAT0017205,MIMAT0017872 miRNA Hspd1 apoptosis Rattus norvegicus cardiomyocytes 17715156 10116 63868 Hsp60|Hspd1-30p RGD:621314|Ensembl:ENSRNOG00000014525 9 9q22 heat shock protein 1 (chaperonin) protein-coding heat shock protein 1 (chaperonin) The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60, HSP70 and caspase-9 in cardiomyocytes. 2774 miR-140 rno-miR-140-5p,rno-miR-140-3p MIMAT0000573,MIMAT0000574 miRNA apoptosis Rattus norvegicus lungs 18952709 10116 The most remarkably down-regulated microRNAs belonged to the families of let-7, miR-10, miR-26, miR-30, miR-34, miR-99, miR-122, miR-123, miR-124, miR-125, miR-140, miR-145, miR-146, miR-191, miR-192, miR-219, miR-222, and miR-223, which regulate stress response, apoptosis, proliferation, angiogenesis, and expression of genes. 2775 miR-145 rno-miR-145-5p,rno-miR-145-3p MIMAT0000851,MIMAT0017131 miRNA apoptosis Rattus norvegicus lungs 18952709 10116 The most remarkably down-regulated microRNAs belonged to the families of let-7, miR-10, miR-26, miR-30, miR-34, miR-99, miR-122, miR-123, miR-124, miR-125, miR-140, miR-145, miR-146, miR-191, miR-192, miR-219, miR-222, and miR-223, which regulate stress response, apoptosis, proliferation, angiogenesis, and expression of genes. 2776 miR-146 rno-miR-146a-5p,rno-miR-146a-3p,rno-miR-146b-5p,rno-miR-146b-3p MIMAT0000852,MIMAT0017132,MIMAT0005595,MIMAT0017334 miRNA apoptosis Rattus norvegicus lungs 18952709 10116 The most remarkably down-regulated microRNAs belonged to the families of let-7, miR-10, miR-26, miR-30, miR-34, miR-99, miR-122, miR-123, miR-124, miR-125, miR-140, miR-145, miR-146, miR-191, miR-192, miR-219, miR-222, and miR-223, which regulate stress response, apoptosis, proliferation, angiogenesis, and expression of genes. 2777 miR-15b rno-miR-15b-5p,rno-miR-15b-3p MIMAT0000784,MIMAT0017093 miRNA Bcl2 apoptosis down Rattus norvegicus pancreatic stellate cells 22487517 10116 24224 Bcl-2 RGD:2199|Ensembl:ENSRNOG00000002791 13 13p13 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 miR-15b and miR-16 could induce apoptosis of rat PSCs by targeting Bcl-2. 2778 miR-16 rno-miR-16-5p,rno-miR-16-3p MIMAT0000785,MIMAT0017094 miRNA Bcl2 apoptosis down Rattus norvegicus pancreatic stellate cells 22487517 10116 24224 Bcl-2 RGD:2199|Ensembl:ENSRNOG00000002791 13 13p13 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 miR-15b and miR-16 could induce apoptosis of rat PSCs by targeting Bcl-2. 2779 miR-16 rno-miR-16-5p,rno-miR-16-3p MIMAT0000785,MIMAT0017094 miRNA apoptosis Rattus norvegicus hepatocellular carcinoma 18942116 10116 We showed that the development of hepatocellular carcinoma (HCC) is characterized by prominent early changes in expression of miRNA genes, specifically by inhibition of expression of microRNAs miR-34a, miR-127, miR-200b, and miR-16a involved in the regulation of apoptosis, cell proliferation, cell-to-cell connection, and epithelial-mesenchymal transition. 2780 miR-16a rno-miR-16-5p,rno-miR-16-3p MIMAT0000785,MIMAT0017094 miRNA apoptosis Rattus norvegicus hepatocellular carcinoma 18942116 10116 We showed that the development of hepatocellular carcinoma (HCC) is characterized by prominent early changes in expression of miRNA genes, specifically by inhibition of expression of microRNAs miR-34a, miR-127, miR-200b, and miR-16a involved in the regulation of apoptosis, cell proliferation, cell-to-cell connection, and epithelial-mesenchymal transition. 2781 miR-191 rno-miR-191a-5p,rno-miR-191a-3p,rno-miR-191b MIMAT0000866,MIMAT0017146,MIMAT0017817 miRNA apoptosis Rattus norvegicus lungs 18952709 10116 The most remarkably down-regulated microRNAs belonged to the families of let-7, miR-10, miR-26, miR-30, miR-34, miR-99, miR-122, miR-123, miR-124, miR-125, miR-140, miR-145, miR-146, miR-191, miR-192, miR-219, miR-222, and miR-223, which regulate stress response, apoptosis, proliferation, angiogenesis, and expression of genes. 2782 miR-192 rno-miR-192-5p,rno-miR-192-3p MIMAT0000867,MIMAT0017147 miRNA apoptosis Rattus norvegicus lungs 18952709 10116 The most remarkably down-regulated microRNAs belonged to the families of let-7, miR-10, miR-26, miR-30, miR-34, miR-99, miR-122, miR-123, miR-124, miR-125, miR-140, miR-145, miR-146, miR-191, miR-192, miR-219, miR-222, and miR-223, which regulate stress response, apoptosis, proliferation, angiogenesis, and expression of genes. 2783 miR-200b rno-miR-200b-3p,rno-miR-200b-5p MIMAT0000875,MIMAT0017152 miRNA apoptosis Rattus norvegicus hepatocellular carcinoma 18942116 10116 We showed that the development of hepatocellular carcinoma (HCC) is characterized by prominent early changes in expression of miRNA genes, specifically by inhibition of expression of microRNAs miR-34a, miR-127, miR-200b, and miR-16a involved in the regulation of apoptosis, cell proliferation, cell-to-cell connection, and epithelial-mesenchymal transition. 2784 miR-219 rno-miR-219a-5p,rno-miR-219a-1-3p,rno-miR-219a-2-3p,rno-miR-219b MIMAT0000889,MIMAT0004741,MIMAT0005446,MIMAT0017882 miRNA apoptosis Rattus norvegicus lungs 18952709 10116 The most remarkably down-regulated microRNAs belonged to the families of let-7, miR-10, miR-26, miR-30, miR-34, miR-99, miR-122, miR-123, miR-124, miR-125, miR-140, miR-145, miR-146, miR-191, miR-192, miR-219, miR-222, and miR-223, which regulate stress response, apoptosis, proliferation, angiogenesis, and expression of genes. 2785 miR-222 rno-miR-222-5p,rno-miR-222-3p MIMAT0017164,MIMAT0000891 miRNA apoptosis Rattus norvegicus lungs 18952709 10116 The most remarkably down-regulated microRNAs belonged to the families of let-7, miR-10, miR-26, miR-30, miR-34, miR-99, miR-122, miR-123, miR-124, miR-125, miR-140, miR-145, miR-146, miR-191, miR-192, miR-219, miR-222, and miR-223, which regulate stress response, apoptosis, proliferation, angiogenesis, and expression of genes. 2786 miR-223 rno-miR-223-3p,rno-miR-223-5p MIMAT0017165,MIMAT0000892 miRNA apoptosis Rattus norvegicus lungs 18952709 10116 The most remarkably down-regulated microRNAs belonged to the families of let-7, miR-10, miR-26, miR-30, miR-34, miR-99, miR-122, miR-123, miR-124, miR-125, miR-140, miR-145, miR-146, miR-191, miR-192, miR-219, miR-222, and miR-223, which regulate stress response, apoptosis, proliferation, angiogenesis, and expression of genes. 2787 miR-26 rno-miR-26a-5p,rno-miR-26a-3p,rno-miR-26b-5p,rno-miR-26b-3p MIMAT0000796,MIMAT0017100,MIMAT0000797 ,MIMAT0004714 miRNA apoptosis Rattus norvegicus lungs 18952709 10116 The most remarkably down-regulated microRNAs belonged to the families of let-7, miR-10, miR-26, miR-30, miR-34, miR-99, miR-122, miR-123, miR-124, miR-125, miR-140, miR-145, miR-146, miR-191, miR-192, miR-219, miR-222, and miR-223, which regulate stress response, apoptosis, proliferation, angiogenesis, and expression of genes. 2788 miR-30 rno-miR-30a-3p,rno-miR-30a-5p,rno-miR-30b-3p,rno-miR-30b-5p,rno-miR-30c-1-3p,rno-miR-30c-2-3p,rno-miR-30c-5p,rno-miR-30d-3p,rno-miR-30d-5p,rno-miR-30e-3p,rno-miR-30e-5p MIMAT0000809,MIMAT0000808,MIMAT0004721,MIMAT0000806,MIMAT0004719,MIMAT0005442,MIMAT0000804,MIMAT0004722,MIMAT0000807,MIMAT0004720,MIMAT0000805 miRNA apoptosis Rattus norvegicus lungs 18952709 10116 The most remarkably down-regulated microRNAs belonged to the families of let-7, miR-10, miR-26, miR-30, miR-34, miR-99, miR-122, miR-123, miR-124, miR-125, miR-140, miR-145, miR-146, miR-191, miR-192, miR-219, miR-222, and miR-223, which regulate stress response, apoptosis, proliferation, angiogenesis, and expression of genes. 2789 miR-34 rno-miR-34a-3p,rno-miR-34a-5p,rno-miR-34b-3p,rno-miR-34b-5p,rno-miR-34c-3p,rno-miR-34c-5p MIMAT0017106,MIMAT0000815,MIMAT0017105,MIMAT0000813,MIMAT0004723,MIMAT0000814 miRNA apoptosis Rattus norvegicus lungs 18952709 10116 The most remarkably down-regulated microRNAs belonged to the families of let-7, miR-10, miR-26, miR-30, miR-34, miR-99, miR-122, miR-123, miR-124, miR-125, miR-140, miR-145, miR-146, miR-191, miR-192, miR-219, miR-222, and miR-223, which regulate stress response, apoptosis, proliferation, angiogenesis, and expression of genes. 2790 miR-34a rno-miR-34a-5p,rno-miR-34a-3p MIMAT0000815,MIMAT0017106 miRNA E2f3 apoptosis down Rattus norvegicus 25594002 10116 291105 RGD1561600 RGD:1561600|Ensembl:ENSRNOG00000029273 17 17p12 E2F transcription factor 3 protein-coding E2F transcription factor 3 Increased expression of miR-34a may be linked to cell cycle arrest and apoptosis. Up-regulation of miR-34a was correlated with down-regulation of its target E2F3 and up-regulation of p53. 2791 miR-34a rno-miR-34a-5p,rno-miR-34a-3p MIMAT0000815,MIMAT0017106 miRNA Tp53 apoptosis up Rattus norvegicus 25594002 10116 24842 Trp53|p53 RGD:3889|Ensembl:ENSRNOG00000010756 10 10q24 tumor protein p53 protein-coding tumor protein p53 Increased expression of miR-34a may be linked to cell cycle arrest and apoptosis. Up-regulation of miR-34a was correlated with down-regulation of its target E2F3 and up-regulation of p53. 2792 miR-34a rno-miR-34a-5p,rno-miR-34a-3p MIMAT0000815,MIMAT0017106 miRNA apoptosis Rattus norvegicus hepatocellular carcinoma 18942116 10116 We showed that the development of hepatocellular carcinoma (HCC) is characterized by prominent early changes in expression of miRNA genes, specifically by inhibition of expression of microRNAs miR-34a, miR-127, miR-200b, and miR-16a involved in the regulation of apoptosis, cell proliferation, cell-to-cell connection, and epithelial-mesenchymal transition. 2793 miR-7a rno-miR-7a-5p,rno-miR-7a-1-3p,rno-miR-7a-2-3p MIMAT0000606,MIMAT0000607,MIMAT0017091 miRNA apoptosis Rattus norvegicus cardiomyoblasts 25302112 10116 Further, ectopic expression of miR-7a provides resistance against UPR-mediated apoptosis in cardiomyoblasts. 2794 miR-99 rno-miR-99a-5p,rno-miR-99a-3p,rno-miR-99b-5p,rno-miR-99ba-3p MIMAT0000820,MIMAT0004724,MIMAT0000821,MIMAT0004725 miRNA apoptosis Rattus norvegicus lungs 18952709 10116 The most remarkably down-regulated microRNAs belonged to the families of let-7, miR-10, miR-26, miR-30, miR-34, miR-99, miR-122, miR-123, miR-124, miR-125, miR-140, miR-145, miR-146, miR-191, miR-192, miR-219, miR-222, and miR-223, which regulate stress response, apoptosis, proliferation, angiogenesis, and expression of genes. 2795 VegT lncRNA nanos1 apoptosis down Xenopus 22399685 262014 397875 nos1|xcat2|xnos1|xcat-2 nanos homolog 1 protein coding Our data indicate that maternal VegT RNA is an authentic target of Nanos1/Pumilio translational repression. We propose that Nanos1 functions to translationally repress RNAs that normally specify endoderm and promote apoptosis, thus preserving the germline. 2796 VegT lncRNA rbm38 apoptosis down Xenopus 22261149 262014 398603 rnpc1|xseb4r Xenbase:XB-GENE-6077629 RNA binding motif protein 38 protein coding RNA binding motif protein 38 Here, we show that forced expression of the RNA-binding protein,XSeb4R, in animal pole blastomeres of Xenopus embryos, inappropriately stabilizes transcripts there, including maternal Sox3. This leads to the impaired ability of the ectodermal progenitors to respond to factors regulating brain patterning and their eventual loss by apoptosis.Conversely, whereas XSeb4R depletion abolishes VegT expression 2797 miR-24a xtr-miR-24a-5p,xtr-miR-24a-3p MIMAT0003653,MIMAT0003654 miRNA apaf1 apoptosis down Xenopus neural retina 19372388 262014 100127738 apaf-1 Xenbase:XB-GENE-988968|M2D:hsa-miR-24 apoptotic peptidase activating factor 1 protein coding apoptotic peptidase activating factor 1 MiR-24a negatively regulates the proapoptotic factors caspase9 and apaf1, demonstrating a role for miRNAs in the regulation of apoptosis during normal development. 2798 miR-24a xtr-miR-24a-5p,xtr-miR-24a-3p MIMAT0003653,MIMAT0003654 miRNA casp9 apoptosis down Xenopus neural retina 19372388 262014 100144708 apaf-3|apaf3|caspase-9|caspase-9c|caspase9|ice-lap6|mch6|xCaspase-9 Xenbase:XB-GENE-483802 caspase 9, apoptosis-related cysteine peptidase protein coding caspase 9, apoptosis-related cysteine peptidase MiR-24a negatively regulates the proapoptotic factors caspase9 and apaf1, demonstrating a role for miRNAs in the regulation of apoptosis during normal development. 2799 dre-miR-144 miR-144 MIMAT0001841 miRNA mapk3 autophagy down Danio rerio prediction 7955 399480 ERK1|fi06b09|wu:fi06b09|zERK1 ZFIN:ZDB-GENE-040121-1|Ensembl:ENSDARG00000070573|Vega:OTTDARG00000032785 3 - mitogen-activated protein kinase 3 protein-coding mitogen-activated protein kinase 3 dre-miR-144 predicted by miR-144 (Homo sapiens), and mapk3 predicted by MAPK3 (Homo sapiens) according to Pubmed ID (25060662) 2800 dre-miR-31 miR-31 MIMAT0003347 miRNA ppp2r4 autophagy down Danio rerio prediction 7955 445031 fc23d07|wu:fc23d07|zgc:92766 ZFIN:ZDB-GENE-040801-11|Ensembl:ENSDARG00000031985|Vega:OTTDARG00000018979 5 - protein phosphatase 2A activator, regulatory subunit 4 protein-coding protein phosphatase 2A activator, regulatory subunit 4 dre-miR-31 predicted by miR-31 (Homo sapiens), and ppp2r4 predicted by PPP2R4 (Homo sapiens) according to Pubmed ID (24343269) 2801 dre-miR-210 miR-210 MIMAT0001281 miRNA hif1ab autophagy down Danio rerio prediction 7955 393202 hif1a|wu:fb63a10|zgc:55405 ZFIN:ZDB-GENE-040426-706|Ensembl:ENSDARG00000034293|Vega:OTTDARG00000004886 20 - hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b protein-coding hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b dre-miR-210 predicted by miR-210 (Homo sapiens), and hif1ab predicted by HIF1A (Homo sapiens) according to Pubmed ID (25385144) 2802 dre-miR-144 miR-144 MIMAT0001841 miRNA atg4a autophagy down Danio rerio prediction 7955 554140 zgc:111958 ZFIN:ZDB-GENE-050522-430|Ensembl:ENSDARG00000014531|Vega:OTTDARG00000031700 21 - autophagy related 4A, cysteine peptidase protein-coding autophagy related 4A, cysteine peptidase dre-miR-144 predicted by miR-144 (Homo sapiens), and atg4a predicted by ATG4A (Homo sapiens) according to Pubmed ID (25652854) 2803 dre-miR-144 miR-144 MIMAT0001841 miRNA mtor autophagy down Danio rerio prediction 7955 324254 frap1|tor|wu:fc22h08 ZFIN:ZDB-GENE-030131-2974|Ensembl:ENSDARG00000053196|Vega:OTTDARG00000026928 8 - mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) dre-miR-144 predicted by miR-144 (Homo sapiens), and mtor predicted by MTOR (Homo sapiens) according to Pubmed ID (25060662) 2804 dre-miR-182 miR-182 MIMAT0001271 miRNA foxo3b autophagy down Danio rerio prediction 7955 30296 fkhr|foxo5|wu:fj65a12|zFkhr ZFIN:ZDB-GENE-990708-6|Ensembl:ENSDARG00000042904|Vega:OTTDARG00000006940 20 - forkhead box O3b protein-coding forkhead box O3b dre-miR-182 predicted by miR-182 (Homo sapiens), and foxo3b predicted by FOXO3 (Homo sapiens) according to Pubmed ID (24871856) 2805 dre-miR-375 miR-375 MIMAT0001876 miRNA map1lc3b autophagy down Danio rerio prediction 7955 322425 Map1lc3|wu:fb60g11|zgc:56434 ZFIN:ZDB-GENE-030131-1145|Ensembl:ENSDARG00000020048|Vega:OTTDARG00000035682 25 - microtubule-associated protein 1 light chain 3 beta protein-coding microtubule-associated protein 1 light chain 3 beta dre-miR-375 predicted by miR-375 (Homo sapiens), and map1lc3b predicted by MAP1LC3B (Homo sapiens) according to Pubmed ID (22929050) 2806 dre-miR-144 miR-144 MIMAT0001841 miRNA gsk3b autophagy down Danio rerio prediction 7955 30654 GSK-3[b]|GSK3|fk80d11|wu:fb68h05|wu:fk80d11 ZFIN:ZDB-GENE-990714-4|Ensembl:ENSDARG00000017803 9 - glycogen synthase kinase 3 beta protein-coding glycogen synthase kinase 3 beta dre-miR-144 predicted by miR-144 (Homo sapiens), and gsk3b predicted by GSK3B (Homo sapiens) according to Pubmed ID (25060662) 2807 dre-miR-375 miR-375 MIMAT0001876 miRNA ywhaqa autophagy down Danio rerio prediction 7955 399487 ywhaq|ywhaq2 ZFIN:ZDB-GENE-040122-5|Ensembl:ENSDARG00000042539|Vega:OTTDARG00000005873 20 - tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a protein-coding tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a dre-miR-375 predicted by miR-375 (Homo sapiens), and ywhaqa predicted by YWHAZ (Homo sapiens) according to Pubmed ID (22606351) 2808 gga-miR-30a-5p miR-30abcdef/30abe-5p/384-5p MIMAT0001135 miRNA BECN1 autophagy down Gallus gallus prediction 9031 420018 - CGNC:51154|Ensembl:ENSGALG00000002973 27 - beclin 1, autophagy related protein-coding beclin 1, autophagy related gga-miR-30a-5p predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and BECN1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 2809 gga-miR-301b-3p miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0007742 miRNA ATG2B autophagy down Gallus gallus prediction 9031 423441 - CGNC:51967|Ensembl:ENSGALG00000011085 5 - autophagy related 2B protein-coding autophagy related 2B gga-miR-301b-3p predicted by miR-130a (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (22902544) 2810 gga-miR-17-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0001114 miRNA HIF1A autophagy down Gallus gallus prediction 9031 374177 - CGNC:8999|Ensembl:ENSGALG00000011870 5 - hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) gga-miR-17-5p predicted by miR-20a (Homo sapiens), and HIF1A predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 2811 gga-miR-30b miR-30abcdef/30abe-5p/384-5p MIMAT0001130 miRNA BNIP3L autophagy down Gallus gallus prediction 9031 419522 - CGNC:131|Ensembl:ENSGALG00000000231 22 - BCL2/adenovirus E1B 19kDa interacting protein 3-like protein-coding BCL2/adenovirus E1B 19kDa interacting protein 3-like gga-miR-30b predicted by miR-30d (Homo sapiens), and BNIP3L predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 2812 gga-miR-16 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0001116 miRNA ATG5 autophagy down Gallus gallus prediction 9031 421784 APG5L CGNC:11461|Ensembl:ENSGALG00000015387 3 - autophagy related 5 protein-coding autophagy related 5 gga-miR-16 predicted by miR-16 (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (23143396) 2813 gga-let-7c let-7/98/4458/4500 MIMAT0001104 miRNA IGF1R autophagy down Gallus gallus prediction 9031 395889 IGF-1R CGNC:49533|Ensembl:ENSGALG00000007039 10 - insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor gga-let-7c predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 2814 gga-miR-454 miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0007292 miRNA ATG2B autophagy down Gallus gallus prediction 9031 423441 - CGNC:51967|Ensembl:ENSGALG00000011085 5 - autophagy related 2B protein-coding autophagy related 2B gga-miR-454 predicted by miR-130a (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (22902544) 2815 gga-miR-30b miR-30abcdef/30abe-5p/384-5p MIMAT0001130 miRNA BECN1 autophagy down Gallus gallus prediction 9031 420018 - CGNC:51154|Ensembl:ENSGALG00000002973 27 - beclin 1, autophagy related protein-coding beclin 1, autophagy related gga-miR-30b predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and BECN1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 2816 gga-miR-106 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0001142 miRNA ULK1 autophagy down Gallus gallus prediction 9031 416800 - CGNC:1714|Ensembl:ENSGALG00000002403 15 - unc-51-like kinase 1 (C. elegans) protein-coding unc-51-like kinase 1 (C. elegans) gga-miR-106 predicted by miR-106b (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 2817 gga-miR-302d miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0003360 miRNA ULK1 autophagy down Gallus gallus prediction 9031 416800 - CGNC:1714|Ensembl:ENSGALG00000002403 15 - unc-51-like kinase 1 (C. elegans) protein-coding unc-51-like kinase 1 (C. elegans) gga-miR-302d predicted by miR-291 (Mus musculus), and ULK1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 2818 gga-miR-30c miR-30abcdef/30abe-5p/384-5p MIMAT0001137 miRNA BECN1 autophagy down Gallus gallus prediction 9031 420018 - CGNC:51154|Ensembl:ENSGALG00000002973 27 - beclin 1, autophagy related protein-coding beclin 1, autophagy related gga-miR-30c predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and BECN1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 2819 gga-let-7f let-7/98/4458/4500 MIMAT0001162 miRNA IGF1R autophagy down Gallus gallus prediction 9031 395889 IGF-1R CGNC:49533|Ensembl:ENSGALG00000007039 10 - insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor gga-let-7f predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 2820 gga-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0001411 miRNA ATG16L1 autophagy down Gallus gallus prediction 9031 424746 APG16L CGNC:1127|Ensembl:ENSGALG00000001619 9 - autophagy related 16-like 1 (S. cerevisiae) protein-coding autophagy related 16-like 1 (S. cerevisiae) gga-miR-20b predicted by miR-106b (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 2821 gga-let-7j let-7/98/4458/4500 MIMAT0001181 miRNA IGF1R autophagy down Gallus gallus prediction 9031 395889 IGF-1R CGNC:49533|Ensembl:ENSGALG00000007039 10 - insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor gga-let-7j predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 2822 gga-let-7a let-7/98/4458/4500 MIMAT0001101 miRNA IGF1R autophagy down Gallus gallus prediction 9031 395889 IGF-1R CGNC:49533|Ensembl:ENSGALG00000007039 10 - insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor gga-let-7a predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 2823 gga-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0001411 miRNA HIF1A autophagy down Gallus gallus prediction 9031 374177 - CGNC:8999|Ensembl:ENSGALG00000011870 5 - hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) gga-miR-20b predicted by miR-20a (Homo sapiens), and HIF1A predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 2824 gga-miR-454 miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0007292 miRNA RB1CC1 autophagy down Gallus gallus prediction 9031 421116 - CGNC:11357|Ensembl:ENSGALG00000015259 2 - RB1-inducible coiled-coil 1 protein-coding RB1-inducible coiled-coil 1 gga-miR-454 predicted by miR-133b (Homo sapiens), and RB1CC1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 2825 gga-miR-106 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0001142 miRNA HIF1A autophagy down Gallus gallus prediction 9031 374177 - CGNC:8999|Ensembl:ENSGALG00000011870 5 - hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) gga-miR-106 predicted by miR-20a (Homo sapiens), and HIF1A predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 2826 gga-let-7b let-7/98/4458/4500 MIMAT0001102 miRNA IGF1R autophagy down Gallus gallus prediction 9031 395889 IGF-1R CGNC:49533|Ensembl:ENSGALG00000007039 10 - insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor gga-let-7b predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 2827 gga-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0001411 miRNA ULK1 autophagy down Gallus gallus prediction 9031 416800 - CGNC:1714|Ensembl:ENSGALG00000002403 15 - unc-51-like kinase 1 (C. elegans) protein-coding unc-51-like kinase 1 (C. elegans) gga-miR-20b predicted by miR-106b (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 2828 gga-let-7d let-7/98/4458/4500 MIMAT0001161 miRNA IGF1R autophagy down Gallus gallus prediction 9031 395889 IGF-1R CGNC:49533|Ensembl:ENSGALG00000007039 10 - insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor gga-let-7d predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 2829 gga-miR-15a miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0001117 miRNA ATG5 autophagy down Gallus gallus prediction 9031 421784 APG5L CGNC:11461|Ensembl:ENSGALG00000015387 3 - autophagy related 5 protein-coding autophagy related 5 gga-miR-15a predicted by miR-16 (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (23143396) 2830 gga-miR-454 miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0007292 miRNA UVRAG autophagy down Gallus gallus prediction 9031 419091 - CGNC:551|Ensembl:ENSGALG00000000845 1 - UV radiation resistance associated gene protein-coding UV radiation resistance associated gene gga-miR-454 predicted by miR-130b (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22228303) 2831 gga-miR-155 miR-155 MIMAT0001106 miRNA RICTOR autophagy down Gallus gallus prediction 9031 427447 - CGNC:53090|Ensembl:ENSGALG00000003775 Z - RPTOR independent companion of MTOR, complex 2 protein-coding RPTOR independent companion of MTOR, complex 2 gga-miR-155 predicted by miR-155 (Homo sapiens), and RICTOR predicted by RICTOR (Homo sapiens) according to Pubmed ID (24262949) 2832 gga-miR-221 miR-221/222/222ab/1928 MIMAT0001108 miRNA CDKN1B autophagy down Gallus gallus prediction 9031 769872 - - 1 - cyclin-dependent kinase inhibitor 1B (p27, Kip1) protein-coding - gga-miR-221 predicted by miR-221 (Homo sapiens), and CDKN1B predicted by CDKN1B (Homo sapiens) according to Pubmed ID (25394488) 2833 gga-miR-302b miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0003357 miRNA ULK1 autophagy down Gallus gallus prediction 9031 416800 - CGNC:1714|Ensembl:ENSGALG00000002403 15 - unc-51-like kinase 1 (C. elegans) protein-coding unc-51-like kinase 1 (C. elegans) gga-miR-302b predicted by miR-291 (Mus musculus), and ULK1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 2834 gga-let-7g let-7/98/4458/4500 MIMAT0001160 miRNA IGF1R autophagy down Gallus gallus prediction 9031 395889 IGF-1R CGNC:49533|Ensembl:ENSGALG00000007039 10 - insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor gga-let-7g predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 2835 gga-miR-30a-5p miR-30abcdef/30abe-5p/384-5p MIMAT0001135 miRNA BNIP3L autophagy down Gallus gallus prediction 9031 419522 - CGNC:131|Ensembl:ENSGALG00000000231 22 - BCL2/adenovirus E1B 19kDa interacting protein 3-like protein-coding BCL2/adenovirus E1B 19kDa interacting protein 3-like gga-miR-30a-5p predicted by miR-30d (Homo sapiens), and BNIP3L predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 2836 gga-miR-301 miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0001166 miRNA UVRAG autophagy down Gallus gallus prediction 9031 419091 - CGNC:551|Ensembl:ENSGALG00000000845 1 - UV radiation resistance associated gene protein-coding UV radiation resistance associated gene gga-miR-301 predicted by miR-130b (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22228303) 2837 gga-miR-130b miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0001165 miRNA RB1CC1 autophagy down Gallus gallus prediction 9031 421116 - CGNC:11357|Ensembl:ENSGALG00000015259 2 - RB1-inducible coiled-coil 1 protein-coding RB1-inducible coiled-coil 1 gga-miR-130b predicted by miR-133b (Homo sapiens), and RB1CC1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 2838 gga-miR-106 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0001142 miRNA ATG7 autophagy down Gallus gallus prediction 9031 415961 - CGNC:3663|Ensembl:ENSGALG00000004932 12 - autophagy related 7 protein-coding autophagy related 7 gga-miR-106 predicted by miR-17 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 2839 gga-miR-17-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0001114 miRNA ATG16L1 autophagy down Gallus gallus prediction 9031 424746 APG16L CGNC:1127|Ensembl:ENSGALG00000001619 9 - autophagy related 16-like 1 (S. cerevisiae) protein-coding autophagy related 16-like 1 (S. cerevisiae) gga-miR-17-5p predicted by miR-106b (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 2840 gga-miR-155 miR-155 MIMAT0001106 miRNA GSK3B autophagy down Gallus gallus prediction 9031 418335 - CGNC:11127|Ensembl:ENSGALG00000014977 1 - glycogen synthase kinase 3 beta protein-coding glycogen synthase kinase 3 beta gga-miR-155 predicted by miR-155 (Homo sapiens), and GSK3B predicted by GSK3B (Homo sapiens) according to Pubmed ID (24343269) 2841 gga-miR-130a miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0001167 miRNA ATG2B autophagy down Gallus gallus prediction 9031 423441 - CGNC:51967|Ensembl:ENSGALG00000011085 5 - autophagy related 2B protein-coding autophagy related 2B gga-miR-130a predicted by miR-130a (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (22902544) 2842 gga-miR-30e miR-30abcdef/30abe-5p/384-5p MIMAT0001177 miRNA BNIP3L autophagy down Gallus gallus prediction 9031 419522 - CGNC:131|Ensembl:ENSGALG00000000231 22 - BCL2/adenovirus E1B 19kDa interacting protein 3-like protein-coding BCL2/adenovirus E1B 19kDa interacting protein 3-like gga-miR-30e predicted by miR-30d (Homo sapiens), and BNIP3L predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 2843 gga-miR-302c miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0003359 miRNA ULK1 autophagy down Gallus gallus prediction 9031 416800 - CGNC:1714|Ensembl:ENSGALG00000002403 15 - unc-51-like kinase 1 (C. elegans) protein-coding unc-51-like kinase 1 (C. elegans) gga-miR-302c predicted by miR-291 (Mus musculus), and ULK1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 2844 gga-miR-130a miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0001167 miRNA RB1CC1 autophagy down Gallus gallus prediction 9031 421116 - CGNC:11357|Ensembl:ENSGALG00000015259 2 - RB1-inducible coiled-coil 1 protein-coding RB1-inducible coiled-coil 1 gga-miR-130a predicted by miR-133b (Homo sapiens), and RB1CC1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 2845 gga-miR-15c miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0007737 miRNA ATG5 autophagy down Gallus gallus prediction 9031 421784 APG5L CGNC:11461|Ensembl:ENSGALG00000015387 3 - autophagy related 5 protein-coding autophagy related 5 gga-miR-15c predicted by miR-16 (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (23143396) 2846 gga-miR-429 miR-200bc/429/548a MIMAT0003371 miRNA UBQLN1 autophagy down Gallus gallus prediction 9031 427454 - CGNC:9551|Ensembl:ENSGALG00000012585 Z - ubiquilin 1 protein-coding ubiquilin 1 gga-miR-429 predicted by miR-200c (Homo sapiens), and UBQLN1 predicted by UBQLN1 (Homo sapiens) according to Pubmed ID (25044403) 2847 gga-miR-30d miR-30abcdef/30abe-5p/384-5p MIMAT0001129 miRNA BNIP3L autophagy down Gallus gallus prediction 9031 419522 - CGNC:131|Ensembl:ENSGALG00000000231 22 - BCL2/adenovirus E1B 19kDa interacting protein 3-like protein-coding BCL2/adenovirus E1B 19kDa interacting protein 3-like gga-miR-30d predicted by miR-30d (Homo sapiens), and BNIP3L predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 2848 gga-miR-17-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0001114 miRNA ULK1 autophagy down Gallus gallus prediction 9031 416800 - CGNC:1714|Ensembl:ENSGALG00000002403 15 - unc-51-like kinase 1 (C. elegans) protein-coding unc-51-like kinase 1 (C. elegans) gga-miR-17-5p predicted by miR-106b (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 2849 gga-miR-211 miR-204/204b/211 MIMAT0003368 miRNA TRPM3 autophagy down Gallus gallus prediction 9031 427249 - CGNC:11255|Ensembl:ENSGALG00000015126 Z - transient receptor potential cation channel, subfamily M, member 3 protein-coding transient receptor potential cation channel, subfamily M, member 3 gga-miR-211 predicted by miR-204 (Homo sapiens), and TRPM3 predicted by TRPM3 (Homo sapiens) according to Pubmed ID (25517751) 2850 gga-miR-30d miR-30abcdef/30abe-5p/384-5p MIMAT0001129 miRNA BECN1 autophagy down Gallus gallus prediction 9031 420018 - CGNC:51154|Ensembl:ENSGALG00000002973 27 - beclin 1, autophagy related protein-coding beclin 1, autophagy related gga-miR-30d predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and BECN1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 2851 gga-miR-222 miR-221/222/222ab/1928 MIMAT0001107 miRNA CDKN1B autophagy down Gallus gallus prediction 9031 769872 - - 1 - cyclin-dependent kinase inhibitor 1B (p27, Kip1) protein-coding - gga-miR-222 predicted by miR-221 (Homo sapiens), and CDKN1B predicted by CDKN1B (Homo sapiens) according to Pubmed ID (25394488) 2852 gga-miR-302d miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0003360 miRNA ATG7 autophagy down Gallus gallus prediction 9031 415961 - CGNC:3663|Ensembl:ENSGALG00000004932 12 - autophagy related 7 protein-coding autophagy related 7 gga-miR-302d predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 2853 gga-miR-130b miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0001165 miRNA UVRAG autophagy down Gallus gallus prediction 9031 419091 - CGNC:551|Ensembl:ENSGALG00000000845 1 - UV radiation resistance associated gene protein-coding UV radiation resistance associated gene gga-miR-130b predicted by miR-130b (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22228303) 2854 gga-miR-30e miR-30abcdef/30abe-5p/384-5p MIMAT0001177 miRNA BECN1 autophagy down Gallus gallus prediction 9031 420018 - CGNC:51154|Ensembl:ENSGALG00000002973 27 - beclin 1, autophagy related protein-coding beclin 1, autophagy related gga-miR-30e predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and BECN1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 2855 gga-miR-30c miR-30abcdef/30abe-5p/384-5p MIMAT0001137 miRNA ATG5 autophagy down Gallus gallus prediction 9031 421784 APG5L CGNC:11461|Ensembl:ENSGALG00000015387 3 - autophagy related 5 protein-coding autophagy related 5 gga-miR-30c predicted by miR-30a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22395361),(22617440),(22902544),(23274497),(24148619) 2856 gga-miR-200b miR-200bc/429/548a MIMAT0001172 miRNA UBQLN1 autophagy down Gallus gallus prediction 9031 427454 - CGNC:9551|Ensembl:ENSGALG00000012585 Z - ubiquilin 1 protein-coding ubiquilin 1 gga-miR-200b predicted by miR-200c (Homo sapiens), and UBQLN1 predicted by UBQLN1 (Homo sapiens) according to Pubmed ID (25044403) 2857 gga-miR-15b miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0001154 miRNA ATG5 autophagy down Gallus gallus prediction 9031 421784 APG5L CGNC:11461|Ensembl:ENSGALG00000015387 3 - autophagy related 5 protein-coding autophagy related 5 gga-miR-15b predicted by miR-16 (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (23143396) 2858 gga-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0001411 miRNA ATG7 autophagy down Gallus gallus prediction 9031 415961 - CGNC:3663|Ensembl:ENSGALG00000004932 12 - autophagy related 7 protein-coding autophagy related 7 gga-miR-20b predicted by miR-17 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 2859 gga-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0001111 miRNA HIF1A autophagy down Gallus gallus prediction 9031 374177 - CGNC:8999|Ensembl:ENSGALG00000011870 5 - hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) gga-miR-20a predicted by miR-20a (Homo sapiens), and HIF1A predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 2860 gga-miR-130c miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0007734 miRNA ATG2B autophagy down Gallus gallus prediction 9031 423441 - CGNC:51967|Ensembl:ENSGALG00000011085 5 - autophagy related 2B protein-coding autophagy related 2B gga-miR-130c predicted by miR-130a (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (22902544) 2861 gga-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0001111 miRNA ATG7 autophagy down Gallus gallus prediction 9031 415961 - CGNC:3663|Ensembl:ENSGALG00000004932 12 - autophagy related 7 protein-coding autophagy related 7 gga-miR-20a predicted by miR-17 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 2862 gga-miR-30b miR-30abcdef/30abe-5p/384-5p MIMAT0001130 miRNA ATG5 autophagy down Gallus gallus prediction 9031 421784 APG5L CGNC:11461|Ensembl:ENSGALG00000015387 3 - autophagy related 5 protein-coding autophagy related 5 gga-miR-30b predicted by miR-30a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22395361),(22617440),(22902544),(23274497),(24148619) 2863 gga-miR-31 miR-31 MIMAT0001189 miRNA GSK3B autophagy down Gallus gallus prediction 9031 418335 - CGNC:11127|Ensembl:ENSGALG00000014977 1 - glycogen synthase kinase 3 beta protein-coding glycogen synthase kinase 3 beta gga-miR-31 predicted by miR-31 (Homo sapiens), and GSK3B predicted by GSK3B (Homo sapiens) according to Pubmed ID (24343269) 2864 gga-miR-30e miR-30abcdef/30abe-5p/384-5p MIMAT0001177 miRNA ATG5 autophagy down Gallus gallus prediction 9031 421784 APG5L CGNC:11461|Ensembl:ENSGALG00000015387 3 - autophagy related 5 protein-coding autophagy related 5 gga-miR-30e predicted by miR-30a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22395361),(22617440),(22902544),(23274497),(24148619) 2865 gga-miR-16c miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0007739 miRNA ATG5 autophagy down Gallus gallus prediction 9031 421784 APG5L CGNC:11461|Ensembl:ENSGALG00000015387 3 - autophagy related 5 protein-coding autophagy related 5 gga-miR-16c predicted by miR-16 (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (23143396) 2866 gga-miR-130b miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0001165 miRNA ATG2B autophagy down Gallus gallus prediction 9031 423441 - CGNC:51967|Ensembl:ENSGALG00000011085 5 - autophagy related 2B protein-coding autophagy related 2B gga-miR-130b predicted by miR-130a (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (22902544) 2867 gga-miR-100 miR-99ab/100 MIMAT0001178 miRNA MTOR autophagy down Gallus gallus prediction 9031 419455 FRAP1 CGNC:2430|Ensembl:ENSGALG00000003339 21 - mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) gga-miR-100 predicted by miR-100 (Homo sapiens), and MTOR predicted by MTOR (Homo sapiens) according to Pubmed ID (25026290) 2868 gga-miR-17-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0001114 miRNA ATG7 autophagy down Gallus gallus prediction 9031 415961 - CGNC:3663|Ensembl:ENSGALG00000004932 12 - autophagy related 7 protein-coding autophagy related 7 gga-miR-17-5p predicted by miR-17 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 2869 gga-miR-22 miR-22/22-3p MIMAT0007288 miRNA BTG1 autophagy down Gallus gallus prediction 9031 396295 - CGNC:49739|Ensembl:ENSGALG00000011276 1 - B-cell translocation gene 1, anti-proliferative protein-coding B-cell translocation gene 1, anti-proliferative gga-miR-22 predicted by miR-22 (Homo sapiens), and BTG1 predicted by BTG1 (Homo sapiens) according to Pubmed ID (25449431) 2870 gga-miR-301b-3p miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0007742 miRNA UVRAG autophagy down Gallus gallus prediction 9031 419091 - CGNC:551|Ensembl:ENSGALG00000000845 1 - UV radiation resistance associated gene protein-coding UV radiation resistance associated gene gga-miR-301b-3p predicted by miR-130b (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22228303) 2871 gga-miR-301b-3p miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0007742 miRNA RB1CC1 autophagy down Gallus gallus prediction 9031 421116 - CGNC:11357|Ensembl:ENSGALG00000015259 2 - RB1-inducible coiled-coil 1 protein-coding RB1-inducible coiled-coil 1 gga-miR-301b-3p predicted by miR-133b (Homo sapiens), and RB1CC1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 2872 gga-miR-155 miR-155 MIMAT0001106 miRNA RHEB autophagy down Gallus gallus prediction 9031 420434 - CGNC:4652 2 - Ras homolog enriched in brain protein-coding Ras homolog enriched in brain gga-miR-155 predicted by miR-155 (Homo sapiens), and RHEB predicted by RHEB (Homo sapiens) according to Pubmed ID (24130493),(24262949) 2873 gga-miR-130c miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0007734 miRNA UVRAG autophagy down Gallus gallus prediction 9031 419091 - CGNC:551|Ensembl:ENSGALG00000000845 1 - UV radiation resistance associated gene protein-coding UV radiation resistance associated gene gga-miR-130c predicted by miR-130b (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22228303) 2874 gga-miR-130c miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0007734 miRNA RB1CC1 autophagy down Gallus gallus prediction 9031 421116 - CGNC:11357|Ensembl:ENSGALG00000015259 2 - RB1-inducible coiled-coil 1 protein-coding RB1-inducible coiled-coil 1 gga-miR-130c predicted by miR-133b (Homo sapiens), and RB1CC1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 2875 gga-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0001111 miRNA ATG16L1 autophagy down Gallus gallus prediction 9031 424746 APG16L CGNC:1127|Ensembl:ENSGALG00000001619 9 - autophagy related 16-like 1 (S. cerevisiae) protein-coding autophagy related 16-like 1 (S. cerevisiae) gga-miR-20a predicted by miR-106b (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 2876 gga-miR-301 miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0001166 miRNA ATG2B autophagy down Gallus gallus prediction 9031 423441 - CGNC:51967|Ensembl:ENSGALG00000011085 5 - autophagy related 2B protein-coding autophagy related 2B gga-miR-301 predicted by miR-130a (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (22902544) 2877 gga-miR-30c miR-30abcdef/30abe-5p/384-5p MIMAT0001137 miRNA BNIP3L autophagy down Gallus gallus prediction 9031 419522 - CGNC:131|Ensembl:ENSGALG00000000231 22 - BCL2/adenovirus E1B 19kDa interacting protein 3-like protein-coding BCL2/adenovirus E1B 19kDa interacting protein 3-like gga-miR-30c predicted by miR-30d (Homo sapiens), and BNIP3L predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 2878 gga-miR-30d miR-30abcdef/30abe-5p/384-5p MIMAT0001129 miRNA ATG5 autophagy down Gallus gallus prediction 9031 421784 APG5L CGNC:11461|Ensembl:ENSGALG00000015387 3 - autophagy related 5 protein-coding autophagy related 5 gga-miR-30d predicted by miR-30a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22395361),(22617440),(22902544),(23274497),(24148619) 2879 gga-miR-99a miR-99ab/100 MIMAT0001103 miRNA IGF1R autophagy down Gallus gallus prediction 9031 395889 IGF-1R CGNC:49533|Ensembl:ENSGALG00000007039 10 - insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor gga-miR-99a predicted by miR-100 (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25026290) 2880 gga-miR-130a miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0001167 miRNA UVRAG autophagy down Gallus gallus prediction 9031 419091 - CGNC:551|Ensembl:ENSGALG00000000845 1 - UV radiation resistance associated gene protein-coding UV radiation resistance associated gene gga-miR-130a predicted by miR-130b (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22228303) 2881 gga-miR-302b miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0003357 miRNA ATG7 autophagy down Gallus gallus prediction 9031 415961 - CGNC:3663|Ensembl:ENSGALG00000004932 12 - autophagy related 7 protein-coding autophagy related 7 gga-miR-302b predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 2882 gga-let-7k let-7/98/4458/4500 MIMAT0001182 miRNA IGF1R autophagy down Gallus gallus prediction 9031 395889 IGF-1R CGNC:49533|Ensembl:ENSGALG00000007039 10 - insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor gga-let-7k predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 2883 gga-miR-302c miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0003359 miRNA ATG7 autophagy down Gallus gallus prediction 9031 415961 - CGNC:3663|Ensembl:ENSGALG00000004932 12 - autophagy related 7 protein-coding autophagy related 7 gga-miR-302c predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 2884 gga-let-7i let-7/98/4458/4500 MIMAT0001098 miRNA IGF1R autophagy down Gallus gallus prediction 9031 395889 IGF-1R CGNC:49533|Ensembl:ENSGALG00000007039 10 - insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor gga-let-7i predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 2885 gga-miR-199 miR-199ab-5p MIMAT0001152 miRNA HSPA5 autophagy down Gallus gallus prediction 9031 396487 GRP78 CGNC:667|Ensembl:ENSGALG00000001000 17 - heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) protein-coding heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) gga-miR-199 predicted by miR-199a-5p (Mus musculus), and HSPA5 predicted by Hspa5 (Mus musculus) according to Pubmed ID (23598416) 2886 gga-miR-106 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0001142 miRNA ATG16L1 autophagy down Gallus gallus prediction 9031 424746 APG16L CGNC:1127|Ensembl:ENSGALG00000001619 9 - autophagy related 16-like 1 (S. cerevisiae) protein-coding autophagy related 16-like 1 (S. cerevisiae) gga-miR-106 predicted by miR-106b (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 2887 gga-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0001111 miRNA ULK1 autophagy down Gallus gallus prediction 9031 416800 - CGNC:1714|Ensembl:ENSGALG00000002403 15 - unc-51-like kinase 1 (C. elegans) protein-coding unc-51-like kinase 1 (C. elegans) gga-miR-20a predicted by miR-106b (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 2888 gga-miR-30a-5p miR-30abcdef/30abe-5p/384-5p MIMAT0001135 miRNA ATG5 autophagy down Gallus gallus prediction 9031 421784 APG5L CGNC:11461|Ensembl:ENSGALG00000015387 3 - autophagy related 5 protein-coding autophagy related 5 gga-miR-30a-5p predicted by miR-30a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22395361),(22617440),(22902544),(23274497),(24148619) 2889 gga-miR-100 miR-99ab/100 MIMAT0001178 miRNA IGF1R autophagy down Gallus gallus prediction 9031 395889 IGF-1R CGNC:49533|Ensembl:ENSGALG00000007039 10 - insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor gga-miR-100 predicted by miR-100 (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25026290) 2890 gga-miR-204 miR-204/204b/211 MIMAT0001156 miRNA TRPM3 autophagy down Gallus gallus prediction 9031 427249 - CGNC:11255|Ensembl:ENSGALG00000015126 Z - transient receptor potential cation channel, subfamily M, member 3 protein-coding transient receptor potential cation channel, subfamily M, member 3 gga-miR-204 predicted by miR-204 (Homo sapiens), and TRPM3 predicted by TRPM3 (Homo sapiens) according to Pubmed ID (25517751) 2891 gga-miR-301 miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0001166 miRNA RB1CC1 autophagy down Gallus gallus prediction 9031 421116 - CGNC:11357|Ensembl:ENSGALG00000015259 2 - RB1-inducible coiled-coil 1 protein-coding RB1-inducible coiled-coil 1 gga-miR-301 predicted by miR-133b (Homo sapiens), and RB1CC1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 2892 gga-miR-99a miR-99ab/100 MIMAT0001103 miRNA MTOR autophagy down Gallus gallus prediction 9031 419455 FRAP1 CGNC:2430|Ensembl:ENSGALG00000003339 21 - mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) gga-miR-99a predicted by miR-100 (Homo sapiens), and MTOR predicted by MTOR (Homo sapiens) according to Pubmed ID (25026290) 2893 mml-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002704 miRNA HIF1A autophagy down Macaca mulatta prediction 9544 704678 - Ensembl:ENSMMUG00000021002 7 - hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding - mml-miR-20a predicted by miR-20a (Homo sapiens), and HIF1A predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 2894 mml-miR-92b miR-25/32/92abc/363/363-3p/367 MIMAT0006177 miRNA LOC709746 autophagy down Macaca mulatta prediction 9544 709746 - Ensembl:ENSMMUG00000015773 11 - serine/threonine-protein kinase ULK1-like protein-coding - mml-miR-92b predicted by miR-25 (Homo sapiens), and LOC709746 predicted by ULK1 (Homo sapiens) according to Pubmed ID (25026296) 2895 mml-miR-374a miR-374ab MIMAT0006300 miRNA TP63 autophagy down Macaca mulatta prediction 9544 703997 - Ensembl:ENSMMUG00000016466 2 - tumor protein p63 protein-coding - mml-miR-374a predicted by miR-374a (Homo sapiens), and TP63 predicted by TP63 (Homo sapiens) according to Pubmed ID (22356768) 2896 mml-miR-34a miR-34ac/34bc-5p/449abc/449c-5p MIMAT0002499 miRNA ATG9A autophagy down Macaca mulatta prediction 9544 702263 - Ensembl:ENSMMUG00000019619 12 - autophagy related 9A protein-coding - mml-miR-34a predicted by miR-34a (Homo sapiens),miR-34a (Rattus norvegicus), and ATG9A predicted by Atg9a (Rattus norvegicus),ATG9A (Homo sapiens) according to Pubmed ID (22902544),(24728149),(24973144) 2897 mml-miR-302d miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0006262 miRNA LOC709746 autophagy down Macaca mulatta prediction 9544 709746 - Ensembl:ENSMMUG00000015773 11 - serine/threonine-protein kinase ULK1-like protein-coding - mml-miR-302d predicted by miR-291 (Mus musculus), and LOC709746 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 2898 mml-miR-519d miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006387 miRNA IRS4 autophagy down Macaca mulatta prediction 9544 707870 - Ensembl:ENSMMUG00000019467 12 - insulin receptor substrate 1-like protein-coding - mml-miR-519d predicted by miR-17 (Mus musculus), and IRS4 predicted by Irs1 (Mus musculus) according to Pubmed ID (25077541) 2899 mml-miR-29b miR-29abcd MIMAT0006168 miRNA ATG14 autophagy down Macaca mulatta prediction 9544 697252 - Ensembl:ENSMMUG00000003761 7 - autophagy related 14 protein-coding - mml-miR-29b predicted by miR-29b (Bos taurus), and ATG14 predicted by ATG14 (Bos taurus) according to Pubmed ID (25234643) 2900 mml-miR-17-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002700 miRNA IRS4 autophagy down Macaca mulatta prediction 9544 707870 - Ensembl:ENSMMUG00000019467 12 - insulin receptor substrate 1-like protein-coding - mml-miR-17-5p predicted by miR-17 (Mus musculus), and IRS4 predicted by Irs1 (Mus musculus) according to Pubmed ID (25077541) 2901 mml-miR-106a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002798 miRNA ATG16L1 autophagy down Macaca mulatta prediction 9544 714092 - Ensembl:ENSMMUG00000023358 12 - autophagy related 16-like 1 (S. cerevisiae) protein-coding - mml-miR-106a predicted by miR-106b (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 2902 mml-miR-30b miR-30abcdef/30abe-5p/384-5p MIMAT0002213 miRNA ATG2B autophagy down Macaca mulatta prediction 9544 712467 - - 7 - autophagy related 2B protein-coding - mml-miR-30b predicted by mir-30d (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (23274497) 2903 mml-miR-454 miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0006338 miRNA ATG2B autophagy down Macaca mulatta prediction 9544 712467 - - 7 - autophagy related 2B protein-coding - mml-miR-454 predicted by miR-130a (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (22902544) 2904 mml-miR-518a-3p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006378 miRNA IRS4 autophagy down Macaca mulatta prediction 9544 707870 - Ensembl:ENSMMUG00000019467 12 - insulin receptor substrate 1-like protein-coding - mml-miR-518a-3p predicted by miR-17 (Mus musculus), and IRS4 predicted by Irs1 (Mus musculus) according to Pubmed ID (25077541) 2905 mml-miR-24 miR-24/24ab/24-3p MIMAT0002337 miRNA ATG4A autophagy down Macaca mulatta prediction 9544 703367 - Ensembl:ENSMMUG00000007190 X - autophagy related 4A, cysteine peptidase protein-coding - mml-miR-24 predicted by miR-24-3p (Homo sapiens), and ATG4A predicted by ATG4A (Homo sapiens) according to Pubmed ID (25426560) 2906 mml-miR-106a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002798 miRNA IRS4 autophagy down Macaca mulatta prediction 9544 707870 - Ensembl:ENSMMUG00000019467 12 - insulin receptor substrate 1-like protein-coding - mml-miR-106a predicted by miR-17 (Mus musculus), and IRS4 predicted by Irs1 (Mus musculus) according to Pubmed ID (25077541) 2907 mml-miR-30e miR-30abcdef/30abe-5p/384-5p MIMAT0006172 miRNA ATG5 autophagy down Macaca mulatta prediction 9544 696874 - Ensembl:ENSMMUG00000019679 4 - autophagy related 5 protein-coding - mml-miR-30e predicted by miR-30a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22395361),(22617440),(22902544),(23274497),(24148619) 2908 mml-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002772 miRNA ATG7 autophagy down Macaca mulatta prediction 9544 696238 - Ensembl:ENSMMUG00000021804 2 - autophagy related 7 protein-coding - mml-miR-106b predicted by miR-17 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 2909 mml-miR-519d miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006387 miRNA BECN1 autophagy down Macaca mulatta prediction 9544 711649 beclin-1 Ensembl:ENSMMUG00000029971 16 - beclin 1, autophagy related protein-coding - mml-miR-519d predicted by miR-17-5p (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (24755562),(25435430),(25485521) 2910 mml-miR-30d miR-30abcdef/30abe-5p/384-5p MIMAT0006171 miRNA BNIP3L autophagy down Macaca mulatta prediction 9544 641440 - Ensembl:ENSMMUG00000023646 8 - BCL2/adenovirus E1B 19kDa interacting protein 3-like protein-coding - mml-miR-30d predicted by miR-30d (Homo sapiens), and BNIP3L predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 2911 mml-miR-519d miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006387 miRNA ATG16L1 autophagy down Macaca mulatta prediction 9544 714092 - Ensembl:ENSMMUG00000023358 12 - autophagy related 16-like 1 (S. cerevisiae) protein-coding - mml-miR-519d predicted by miR-106b (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 2912 mml-miR-519d miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006387 miRNA HIF1A autophagy down Macaca mulatta prediction 9544 704678 - Ensembl:ENSMMUG00000021002 7 - hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding - mml-miR-519d predicted by miR-20a (Homo sapiens), and HIF1A predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 2913 mml-miR-429 miR-200bc/429/548a MIMAT0006325 miRNA HMOX1 autophagy down Macaca mulatta prediction 9544 719266 - Ensembl:ENSMMUG00000007221 10 - heme oxygenase (decycling) 1 protein-coding - mml-miR-429 predicted by miR-200c (Homo sapiens), and HMOX1 predicted by HMOX1 (Homo sapiens) according to Pubmed ID (25150313) 2914 mml-miR-106a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002798 miRNA ATG5 autophagy down Macaca mulatta prediction 9544 696874 - Ensembl:ENSMMUG00000019679 4 - autophagy related 5 protein-coding - mml-miR-106a predicted by miR-20a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (25485521) 2915 mml-miR-181a miR-181abcd/4262 MIMAT0002506 miRNA UVRAG autophagy down Macaca mulatta prediction 9544 696601 - Ensembl:ENSMMUG00000000187 14 - UV radiation resistance associated gene protein-coding - mml-miR-181a predicted by miR-181a (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22356768) 2916 mml-miR-215 miR-192/215 MIMAT0002728 miRNA MAP1LC3B autophagy down Macaca mulatta prediction 9544 695419 - Ensembl:ENSMMUG00000017613 20 - microtubule-associated protein 1 light chain 3 beta protein-coding - mml-miR-215 predicted by miR-192 (Homo sapiens), and MAP1LC3B predicted by MAP1LC3B (Homo sapiens) according to Pubmed ID (22135297) 2917 mml-let-7f let-7/98/4458/4500 MIMAT0006156 miRNA IGF1R autophagy down Macaca mulatta prediction 9544 708227 - Ensembl:ENSMMUG00000012305 7 - insulin-like growth factor 1 receptor protein-coding - mml-let-7f predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 2918 mml-miR-181c miR-181abcd/4262 MIMAT0002509 miRNA ATG5 autophagy down Macaca mulatta prediction 9544 696874 - Ensembl:ENSMMUG00000019679 4 - autophagy related 5 protein-coding - mml-miR-181c predicted by miR-181a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22356768),(22902544),(23322078) 2919 mml-let-7i let-7/98/4458/4500 MIMAT0006158 miRNA IGF1R autophagy down Macaca mulatta prediction 9544 708227 - Ensembl:ENSMMUG00000012305 7 - insulin-like growth factor 1 receptor protein-coding - mml-let-7i predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 2920 mml-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006164 miRNA FYCO1 autophagy down Macaca mulatta prediction 9544 713756 - Ensembl:ENSMMUG00000023585 2 - FYVE and coiled-coil domain containing 1 protein-coding - mml-miR-20b predicted by miR-93 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 2921 mml-miR-302a miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0006259 miRNA FYCO1 autophagy down Macaca mulatta prediction 9544 713756 - Ensembl:ENSMMUG00000023585 2 - FYVE and coiled-coil domain containing 1 protein-coding - mml-miR-302a predicted by miR-373 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 2922 mml-miR-454 miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0006338 miRNA RB1CC1 autophagy down Macaca mulatta prediction 9544 710330 - Ensembl:ENSMMUG00000009990 8 - RB1-inducible coiled-coil 1 protein-coding - mml-miR-454 predicted by miR-133b (Homo sapiens), and RB1CC1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 2923 mml-miR-181b miR-181abcd/4262 MIMAT0002623 miRNA ATG5 autophagy down Macaca mulatta prediction 9544 696874 - Ensembl:ENSMMUG00000019679 4 - autophagy related 5 protein-coding - mml-miR-181b predicted by miR-181a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22356768),(22902544),(23322078) 2924 mml-miR-29b miR-29abcd MIMAT0006168 miRNA LOC716580 autophagy down Macaca mulatta prediction 9544 716580 - Ensembl:ENSMMUG00000008104 13 - proteasome activator complex subunit 4-like protein-coding - mml-miR-29b predicted by miR-29b (Homo sapiens), and LOC716580 predicted by PSME4 (Homo sapiens) according to Pubmed ID (25234165) 2925 mml-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002704 miRNA IRS4 autophagy down Macaca mulatta prediction 9544 707870 - Ensembl:ENSMMUG00000019467 12 - insulin receptor substrate 1-like protein-coding - mml-miR-20a predicted by miR-17 (Mus musculus), and IRS4 predicted by Irs1 (Mus musculus) according to Pubmed ID (25077541) 2926 mml-miR-181b miR-181abcd/4262 MIMAT0002623 miRNA UVRAG autophagy down Macaca mulatta prediction 9544 696601 - Ensembl:ENSMMUG00000000187 14 - UV radiation resistance associated gene protein-coding - mml-miR-181b predicted by miR-181a (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22356768) 2927 mml-miR-192 miR-192/215 MIMAT0006224 miRNA UVRAG autophagy down Macaca mulatta prediction 9544 696601 - Ensembl:ENSMMUG00000000187 14 - UV radiation resistance associated gene protein-coding - mml-miR-192 predicted by miR-215 (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (19074876),(22135297) 2928 mml-miR-518a-3p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006378 miRNA ATG7 autophagy down Macaca mulatta prediction 9544 696238 - Ensembl:ENSMMUG00000021804 2 - autophagy related 7 protein-coding - mml-miR-518a-3p predicted by miR-17 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 2929 mml-miR-15a miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0002650 miRNA ATG14 autophagy down Macaca mulatta prediction 9544 697252 - Ensembl:ENSMMUG00000003761 7 - autophagy related 14 protein-coding - mml-miR-15a predicted by miR-195 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 2930 mml-miR-221 miR-221/222/222ab/1928 MIMAT0002583 miRNA CDKN1B autophagy down Macaca mulatta prediction 9544 697188 - Ensembl:ENSMMUG00000022370 11 - cyclin-dependent kinase inhibitor 1B (p27, Kip1) protein-coding - mml-miR-221 predicted by miR-221 (Homo sapiens), and CDKN1B predicted by CDKN1B (Homo sapiens) according to Pubmed ID (25394488) 2931 mml-miR-373 miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0006299 miRNA ATG7 autophagy down Macaca mulatta prediction 9544 696238 - Ensembl:ENSMMUG00000021804 2 - autophagy related 7 protein-coding - mml-miR-373 predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 2932 mml-miR-186 miR-186 MIMAT0006220 miRNA LOC709746 autophagy down Macaca mulatta prediction 9544 709746 - Ensembl:ENSMMUG00000015773 11 - serine/threonine-protein kinase ULK1-like protein-coding - mml-miR-186 predicted by miR-186 (Homo sapiens), and LOC709746 predicted by ULK1 (Homo sapiens) according to Pubmed ID (23622248) 2933 mml-miR-374b miR-374ab MIMAT0006301 miRNA TP63 autophagy down Macaca mulatta prediction 9544 703997 - Ensembl:ENSMMUG00000016466 2 - tumor protein p63 protein-coding - mml-miR-374b predicted by miR-374a (Homo sapiens), and TP63 predicted by TP63 (Homo sapiens) according to Pubmed ID (22356768) 2934 mml-miR-374a miR-374ab MIMAT0006300 miRNA LOC711835 autophagy down Macaca mulatta prediction 9544 711835 - - 6 - autophagy-related protein 10-like protein-coding - mml-miR-374a predicted by miR-374a (Homo sapiens), and LOC711835 predicted by ATG10 (Homo sapiens) according to Pubmed ID (22356768) 2935 mml-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002704 miRNA ATG7 autophagy down Macaca mulatta prediction 9544 696238 - Ensembl:ENSMMUG00000021804 2 - autophagy related 7 protein-coding - mml-miR-20a predicted by miR-17 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 2936 mml-miR-16 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0002651 miRNA BAG5 autophagy down Macaca mulatta prediction 9544 699170 - Ensembl:ENSMMUG00000017005 7 - BCL2-associated athanogene 5 protein-coding - mml-miR-16 predicted by miR-16 (Mus musculus), and BAG5 predicted by Bag5 (Mus musculus) according to Pubmed ID (21770019) 2937 mml-miR-222 miR-221/222/222ab/1928 MIMAT0006250 miRNA CDKN1B autophagy down Macaca mulatta prediction 9544 697188 - Ensembl:ENSMMUG00000022370 11 - cyclin-dependent kinase inhibitor 1B (p27, Kip1) protein-coding - mml-miR-222 predicted by miR-221 (Homo sapiens), and CDKN1B predicted by CDKN1B (Homo sapiens) according to Pubmed ID (25394488) 2938 mml-miR-367 miR-25/32/92abc/363/363-3p/367 MIMAT0006292 miRNA UVRAG autophagy down Macaca mulatta prediction 9544 696601 - Ensembl:ENSMMUG00000000187 14 - UV radiation resistance associated gene protein-coding - mml-miR-367 predicted by miR-32 (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22135297) 2939 mml-miR-199a miR-199ab-5p MIMAT0002531 miRNA DRAM1 autophagy down Macaca mulatta prediction 9544 697427 DRAM Ensembl:ENSMMUG00000004689 11 - DNA-damage regulated autophagy modulator 1 protein-coding - mml-miR-199a predicted by miR-199a-5p (Homo sapiens), and DRAM1 predicted by DRAM1 (Homo sapiens) according to Pubmed ID (23337876) 2940 mml-miR-373 miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0006299 miRNA FYCO1 autophagy down Macaca mulatta prediction 9544 713756 - Ensembl:ENSMMUG00000023585 2 - FYVE and coiled-coil domain containing 1 protein-coding - mml-miR-373 predicted by miR-373 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 2941 mml-miR-192 miR-192/215 MIMAT0006224 miRNA MAP1LC3B autophagy down Macaca mulatta prediction 9544 695419 - Ensembl:ENSMMUG00000017613 20 - microtubule-associated protein 1 light chain 3 beta protein-coding - mml-miR-192 predicted by miR-192 (Homo sapiens), and MAP1LC3B predicted by MAP1LC3B (Homo sapiens) according to Pubmed ID (22135297) 2942 mml-miR-132 miR-132/212/212-3p MIMAT0006188 miRNA FOXO3 autophagy down Macaca mulatta prediction 9544 700731 - - 4 - forkhead box O3 protein-coding - mml-miR-132 predicted by miR-132 (Mus musculus), and FOXO3 predicted by Foxo3 (Mus musculus) according to Pubmed ID (23011132) 2943 mml-miR-215 miR-192/215 MIMAT0002728 miRNA UVRAG autophagy down Macaca mulatta prediction 9544 696601 - Ensembl:ENSMMUG00000000187 14 - UV radiation resistance associated gene protein-coding - mml-miR-215 predicted by miR-215 (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (19074876),(22135297) 2944 mml-miR-93 miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0002773 miRNA FYCO1 autophagy down Macaca mulatta prediction 9544 713756 - Ensembl:ENSMMUG00000023585 2 - FYVE and coiled-coil domain containing 1 protein-coding - mml-miR-93 predicted by miR-373 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 2945 mml-let-7a let-7/98/4458/4500 MIMAT0006151 miRNA OLR1 autophagy down Macaca mulatta prediction 9544 717596 - Ensembl:ENSMMUG00000002191 11 - oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding - mml-let-7a predicted by let-7g (Mus musculus), and OLR1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 2946 mml-miR-181a miR-181abcd/4262 MIMAT0002506 miRNA TP63 autophagy down Macaca mulatta prediction 9544 703997 - Ensembl:ENSMMUG00000016466 2 - tumor protein p63 protein-coding - mml-miR-181a predicted by miR-181a (Homo sapiens), and TP63 predicted by TP63 (Homo sapiens) according to Pubmed ID (22356768) 2947 mml-miR-520a miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0006388 miRNA SQSTM1 autophagy down Macaca mulatta prediction 9544 705481 - Ensembl:ENSMMUG00000021055 6 - sequestosome 1 protein-coding - mml-miR-520a predicted by miR-372 (Homo sapiens), and SQSTM1 predicted by SQSTM1 (Homo sapiens) according to Pubmed ID (24991827) 2948 mml-miR-29b miR-29abcd MIMAT0006168 miRNA ATG9A autophagy down Macaca mulatta prediction 9544 702263 - Ensembl:ENSMMUG00000019619 12 - autophagy related 9A protein-coding - mml-miR-29b predicted by miR-29b (Bos taurus), and ATG9A predicted by ATG9A (Bos taurus) according to Pubmed ID (25234643) 2949 mml-miR-497 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0006359 miRNA BAG5 autophagy down Macaca mulatta prediction 9544 699170 - Ensembl:ENSMMUG00000017005 7 - BCL2-associated athanogene 5 protein-coding - mml-miR-497 predicted by miR-16 (Mus musculus), and BAG5 predicted by Bag5 (Mus musculus) according to Pubmed ID (21770019) 2950 mml-miR-302d miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0006262 miRNA SQSTM1 autophagy down Macaca mulatta prediction 9544 705481 - Ensembl:ENSMMUG00000021055 6 - sequestosome 1 protein-coding - mml-miR-302d predicted by miR-372 (Homo sapiens), and SQSTM1 predicted by SQSTM1 (Homo sapiens) according to Pubmed ID (24991827) 2951 mml-let-7b let-7/98/4458/4500 MIMAT0006152 miRNA OLR1 autophagy down Macaca mulatta prediction 9544 717596 - Ensembl:ENSMMUG00000002191 11 - oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding - mml-let-7b predicted by let-7g (Mus musculus), and OLR1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 2952 mml-miR-301a miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0006257 miRNA ATG2B autophagy down Macaca mulatta prediction 9544 712467 - - 7 - autophagy related 2B protein-coding - mml-miR-301a predicted by miR-130a (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (22902544) 2953 mml-miR-18 miR-18ab/4735-3p MIMAT0002702 miRNA ATM autophagy down Macaca mulatta prediction 9544 100427400 - Ensembl:ENSMMUG00000004153 14 - ataxia telangiectasia mutated protein-coding - mml-miR-18 predicted by miR-18a (Homo sapiens), and ATM predicted by ATM (Homo sapiens) according to Pubmed ID (23229340) 2954 mml-miR-30e miR-30abcdef/30abe-5p/384-5p MIMAT0006172 miRNA BNIP3L autophagy down Macaca mulatta prediction 9544 641440 - Ensembl:ENSMMUG00000023646 8 - BCL2/adenovirus E1B 19kDa interacting protein 3-like protein-coding - mml-miR-30e predicted by miR-30d (Homo sapiens), and BNIP3L predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 2955 mml-miR-30a-5p miR-30abcdef/30abe-5p/384-5p MIMAT0002369 miRNA ATG2B autophagy down Macaca mulatta prediction 9544 712467 - - 7 - autophagy related 2B protein-coding - mml-miR-30a-5p predicted by mir-30d (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (23274497) 2956 mml-miR-17-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002700 miRNA ATG7 autophagy down Macaca mulatta prediction 9544 696238 - Ensembl:ENSMMUG00000021804 2 - autophagy related 7 protein-coding - mml-miR-17-5p predicted by miR-17 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 2957 mml-miR-30e miR-30abcdef/30abe-5p/384-5p MIMAT0006172 miRNA ATG2B autophagy down Macaca mulatta prediction 9544 712467 - - 7 - autophagy related 2B protein-coding - mml-miR-30e predicted by mir-30d (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (23274497) 2958 mml-miR-211 miR-204/204b/211 MIMAT0002547 miRNA TRPM3 autophagy down Macaca mulatta prediction 9544 702898 - Ensembl:ENSMMUG00000006156 15 - transient receptor potential cation channel, subfamily M, member 3 protein-coding - mml-miR-211 predicted by miR-204 (Homo sapiens), and TRPM3 predicted by TRPM3 (Homo sapiens) according to Pubmed ID (25517751) 2959 mml-miR-506 miR-124/124ab/506 MIMAT0005762 miRNA ANTXR2 autophagy down Macaca mulatta prediction 9544 696513 - - 5 - anthrax toxin receptor 2 protein-coding - mml-miR-506 predicted by miR-124 (Homo sapiens), and ANTXR2 predicted by ANTXR2 (Homo sapiens) according to Pubmed ID (25736362) 2960 mml-miR-181a miR-181abcd/4262 MIMAT0002506 miRNA ATG5 autophagy down Macaca mulatta prediction 9544 696874 - Ensembl:ENSMMUG00000019679 4 - autophagy related 5 protein-coding - mml-miR-181a predicted by miR-181a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22356768),(22902544),(23322078) 2961 mml-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006164 miRNA ATG5 autophagy down Macaca mulatta prediction 9544 696874 - Ensembl:ENSMMUG00000019679 4 - autophagy related 5 protein-coding - mml-miR-20b predicted by miR-20a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (25485521) 2962 mml-miR-519a miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0006384 miRNA SQSTM1 autophagy down Macaca mulatta prediction 9544 705481 - Ensembl:ENSMMUG00000021055 6 - sequestosome 1 protein-coding - mml-miR-519a predicted by miR-372 (Homo sapiens), and SQSTM1 predicted by SQSTM1 (Homo sapiens) according to Pubmed ID (24991827) 2963 mml-miR-375 miR-375 MIMAT0006302 miRNA SP1 autophagy down Macaca mulatta prediction 9544 702710 - - 11 - Sp1 transcription factor protein-coding - mml-miR-375 predicted by miR-375 (Homo sapiens), and SP1 predicted by SP1 (Homo sapiens) according to Pubmed ID (22606351) 2964 mml-miR-30a-5p miR-30abcdef/30abe-5p/384-5p MIMAT0002369 miRNA BECN1 autophagy down Macaca mulatta prediction 9544 711649 beclin-1 Ensembl:ENSMMUG00000029971 16 - beclin 1, autophagy related protein-coding - mml-miR-30a-5p predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and BECN1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 2965 mml-let-7d let-7/98/4458/4500 MIMAT0006154 miRNA OLR1 autophagy down Macaca mulatta prediction 9544 717596 - Ensembl:ENSMMUG00000002191 11 - oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding - mml-let-7d predicted by let-7g (Mus musculus), and OLR1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 2966 mml-miR-30e miR-30abcdef/30abe-5p/384-5p MIMAT0006172 miRNA MAP1LC3B autophagy down Macaca mulatta prediction 9544 695419 - Ensembl:ENSMMUG00000017613 20 - microtubule-associated protein 1 light chain 3 beta protein-coding - mml-miR-30e predicted by miR-30a (Homo sapiens), and MAP1LC3B predicted by MAP1LC3B (Homo sapiens) according to Pubmed ID (22135297) 2967 mml-miR-15a miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0002650 miRNA BAG5 autophagy down Macaca mulatta prediction 9544 699170 - Ensembl:ENSMMUG00000017005 7 - BCL2-associated athanogene 5 protein-coding - mml-miR-15a predicted by miR-16 (Mus musculus), and BAG5 predicted by Bag5 (Mus musculus) according to Pubmed ID (21770019) 2968 mml-miR-518a-3p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006378 miRNA HIF1A autophagy down Macaca mulatta prediction 9544 704678 - Ensembl:ENSMMUG00000021002 7 - hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding - mml-miR-518a-3p predicted by miR-20a (Homo sapiens), and HIF1A predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 2969 mml-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002704 miRNA ATG5 autophagy down Macaca mulatta prediction 9544 696874 - Ensembl:ENSMMUG00000019679 4 - autophagy related 5 protein-coding - mml-miR-20a predicted by miR-20a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (25485521) 2970 mml-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006164 miRNA MAP1LC3B autophagy down Macaca mulatta prediction 9544 695419 - Ensembl:ENSMMUG00000017613 20 - microtubule-associated protein 1 light chain 3 beta protein-coding - mml-miR-20b predicted by miR-20a (Homo sapiens), and MAP1LC3B predicted by MAP1LC3B (Homo sapiens) according to Pubmed ID (25485521) 2971 mml-miR-30d miR-30abcdef/30abe-5p/384-5p MIMAT0006171 miRNA ATG5 autophagy down Macaca mulatta prediction 9544 696874 - Ensembl:ENSMMUG00000019679 4 - autophagy related 5 protein-coding - mml-miR-30d predicted by miR-30a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22395361),(22617440),(22902544),(23274497),(24148619) 2972 mml-miR-106a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002798 miRNA ATG7 autophagy down Macaca mulatta prediction 9544 696238 - Ensembl:ENSMMUG00000021804 2 - autophagy related 7 protein-coding - mml-miR-106a predicted by miR-17 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 2973 mml-miR-519d miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006387 miRNA SQSTM1 autophagy down Macaca mulatta prediction 9544 705481 - Ensembl:ENSMMUG00000021055 6 - sequestosome 1 protein-coding - mml-miR-519d predicted by miR-106b (Homo sapiens),miR-106 (Mus musculus), and SQSTM1 predicted by Sqstm1 (Mus musculus),SQSTM1 (Homo sapiens) according to Pubmed ID (21628417),(22441107),(25485521),(25617127) 2974 mml-miR-98 let-7/98/4458/4500 MIMAT0002404 miRNA OLR1 autophagy down Macaca mulatta prediction 9544 717596 - Ensembl:ENSMMUG00000002191 11 - oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding - mml-miR-98 predicted by let-7g (Mus musculus), and OLR1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 2975 mml-miR-373 miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0006299 miRNA LOC709746 autophagy down Macaca mulatta prediction 9544 709746 - Ensembl:ENSMMUG00000015773 11 - serine/threonine-protein kinase ULK1-like protein-coding - mml-miR-373 predicted by miR-291 (Mus musculus), and LOC709746 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 2976 mml-miR-30b miR-30abcdef/30abe-5p/384-5p MIMAT0002213 miRNA BECN1 autophagy down Macaca mulatta prediction 9544 711649 beclin-1 Ensembl:ENSMMUG00000029971 16 - beclin 1, autophagy related protein-coding - mml-miR-30b predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and BECN1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 2977 mml-miR-302b miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0006260 miRNA LOC709746 autophagy down Macaca mulatta prediction 9544 709746 - Ensembl:ENSMMUG00000015773 11 - serine/threonine-protein kinase ULK1-like protein-coding - mml-miR-302b predicted by miR-291 (Mus musculus), and LOC709746 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 2978 mml-miR-519d miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006387 miRNA FYCO1 autophagy down Macaca mulatta prediction 9544 713756 - Ensembl:ENSMMUG00000023585 2 - FYVE and coiled-coil domain containing 1 protein-coding - mml-miR-519d predicted by miR-93 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 2979 mml-miR-375 miR-375 MIMAT0006302 miRNA RB1CC1 autophagy down Macaca mulatta prediction 9544 710330 - Ensembl:ENSMMUG00000009990 8 - RB1-inducible coiled-coil 1 protein-coding - mml-miR-375 predicted by miR-375 (Homo sapiens), and RB1CC1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (22135297) 2980 mml-miR-519a miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0006384 miRNA ATG7 autophagy down Macaca mulatta prediction 9544 696238 - Ensembl:ENSMMUG00000021804 2 - autophagy related 7 protein-coding - mml-miR-519a predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 2981 mml-miR-590-5p miR-21/590-5p MIMAT0006450 miRNA PTEN autophagy down Macaca mulatta prediction 9544 720411 - - 10 - phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like pseudo - mml-miR-590-5p predicted by miR-21 (Rattus norvegicus), and PTEN predicted by Pten (Rattus norvegicus) according to Pubmed ID (25689721) 2982 mml-miR-302a miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0006259 miRNA ATG7 autophagy down Macaca mulatta prediction 9544 696238 - Ensembl:ENSMMUG00000021804 2 - autophagy related 7 protein-coding - mml-miR-302a predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 2983 mml-miR-204 miR-204/204b/211 MIMAT0006235 miRNA MAP1LC3B autophagy down Macaca mulatta prediction 9544 695419 - Ensembl:ENSMMUG00000017613 20 - microtubule-associated protein 1 light chain 3 beta protein-coding - mml-miR-204 predicted by miR-204 (Homo sapiens),miR-204 (Rattus norvegicus), and MAP1LC3B predicted by Map1lc3b (Rattus norvegicus),MAP1LC3B (Homo sapiens) according to Pubmed ID (21316776),(21631941),(22516261),(25209181),(25517751) 2984 mml-miR-181b miR-181abcd/4262 MIMAT0002623 miRNA TP63 autophagy down Macaca mulatta prediction 9544 703997 - Ensembl:ENSMMUG00000016466 2 - tumor protein p63 protein-coding - mml-miR-181b predicted by miR-181a (Homo sapiens), and TP63 predicted by TP63 (Homo sapiens) according to Pubmed ID (22356768) 2985 mml-miR-497 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0006359 miRNA ATG14 autophagy down Macaca mulatta prediction 9544 697252 - Ensembl:ENSMMUG00000003761 7 - autophagy related 14 protein-coding - mml-miR-497 predicted by miR-195 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 2986 mml-miR-93 miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0002773 miRNA SQSTM1 autophagy down Macaca mulatta prediction 9544 705481 - Ensembl:ENSMMUG00000021055 6 - sequestosome 1 protein-coding - mml-miR-93 predicted by miR-372 (Homo sapiens), and SQSTM1 predicted by SQSTM1 (Homo sapiens) according to Pubmed ID (24991827) 2987 mml-miR-29c miR-29abcd MIMAT0006169 miRNA ATG9A autophagy down Macaca mulatta prediction 9544 702263 - Ensembl:ENSMMUG00000019619 12 - autophagy related 9A protein-coding - mml-miR-29c predicted by miR-29b (Bos taurus), and ATG9A predicted by ATG9A (Bos taurus) according to Pubmed ID (25234643) 2988 mml-miR-181d miR-181abcd/4262 MIMAT0006217 miRNA ATG5 autophagy down Macaca mulatta prediction 9544 696874 - Ensembl:ENSMMUG00000019679 4 - autophagy related 5 protein-coding - mml-miR-181d predicted by miR-181a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22356768),(22902544),(23322078) 2989 mml-miR-519a miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0006384 miRNA FYCO1 autophagy down Macaca mulatta prediction 9544 713756 - Ensembl:ENSMMUG00000023585 2 - FYVE and coiled-coil domain containing 1 protein-coding - mml-miR-519a predicted by miR-373 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 2990 mml-let-7i let-7/98/4458/4500 MIMAT0006158 miRNA OLR1 autophagy down Macaca mulatta prediction 9544 717596 - Ensembl:ENSMMUG00000002191 11 - oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding - mml-let-7i predicted by let-7g (Mus musculus), and OLR1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 2991 mml-miR-372 miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0006298 miRNA ATG7 autophagy down Macaca mulatta prediction 9544 696238 - Ensembl:ENSMMUG00000021804 2 - autophagy related 7 protein-coding - mml-miR-372 predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 2992 mml-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006164 miRNA ATG16L1 autophagy down Macaca mulatta prediction 9544 714092 - Ensembl:ENSMMUG00000023358 12 - autophagy related 16-like 1 (S. cerevisiae) protein-coding - mml-miR-20b predicted by miR-106b (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 2993 mml-miR-137 miR-137/137ab MIMAT0006193 miRNA BNIP3L autophagy down Macaca mulatta prediction 9544 641440 - Ensembl:ENSMMUG00000023646 8 - BCL2/adenovirus E1B 19kDa interacting protein 3-like protein-coding - mml-miR-137 predicted by miR-137 (Homo sapiens), and BNIP3L predicted by BNIP3L (Homo sapiens) according to Pubmed ID (24573672) 2994 mml-miR-130b miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0006187 miRNA RB1CC1 autophagy down Macaca mulatta prediction 9544 710330 - Ensembl:ENSMMUG00000009990 8 - RB1-inducible coiled-coil 1 protein-coding - mml-miR-130b predicted by miR-133b (Homo sapiens), and RB1CC1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 2995 mml-miR-106a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002798 miRNA MAP1LC3B autophagy down Macaca mulatta prediction 9544 695419 - Ensembl:ENSMMUG00000017613 20 - microtubule-associated protein 1 light chain 3 beta protein-coding - mml-miR-106a predicted by miR-20a (Homo sapiens), and MAP1LC3B predicted by MAP1LC3B (Homo sapiens) according to Pubmed ID (25485521) 2996 mml-miR-224 miR-224 MIMAT0002594 miRNA SMAD4 autophagy down Macaca mulatta prediction 9544 701803 - - 18 - SMAD family member 4 protein-coding - mml-miR-224 predicted by miR-224 (Homo sapiens), and SMAD4 predicted by SMAD4 (Homo sapiens) according to Pubmed ID (23913306),(25068270) 2997 mml-miR-302c miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0006261 miRNA ATG7 autophagy down Macaca mulatta prediction 9544 696238 - Ensembl:ENSMMUG00000021804 2 - autophagy related 7 protein-coding - mml-miR-302c predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 2998 mml-miR-30c miR-30abcdef/30abe-5p/384-5p MIMAT0006170 miRNA MAP1LC3B autophagy down Macaca mulatta prediction 9544 695419 - Ensembl:ENSMMUG00000017613 20 - microtubule-associated protein 1 light chain 3 beta protein-coding - mml-miR-30c predicted by miR-30a (Homo sapiens), and MAP1LC3B predicted by MAP1LC3B (Homo sapiens) according to Pubmed ID (22135297) 2999 mml-miR-211 miR-204/204b/211 MIMAT0002547 miRNA MAP1LC3B autophagy down Macaca mulatta prediction 9544 695419 - Ensembl:ENSMMUG00000017613 20 - microtubule-associated protein 1 light chain 3 beta protein-coding - mml-miR-211 predicted by miR-204 (Homo sapiens),miR-204 (Rattus norvegicus), and MAP1LC3B predicted by Map1lc3b (Rattus norvegicus),MAP1LC3B (Homo sapiens) according to Pubmed ID (21316776),(21631941),(22516261),(25209181),(25517751) 3000 mml-miR-518a-3p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006378 miRNA SQSTM1 autophagy down Macaca mulatta prediction 9544 705481 - Ensembl:ENSMMUG00000021055 6 - sequestosome 1 protein-coding - mml-miR-518a-3p predicted by miR-106b (Homo sapiens),miR-106 (Mus musculus), and SQSTM1 predicted by Sqstm1 (Mus musculus),SQSTM1 (Homo sapiens) according to Pubmed ID (21628417),(22441107),(25485521),(25617127) 3001 mml-miR-30b miR-30abcdef/30abe-5p/384-5p MIMAT0002213 miRNA ATG5 autophagy down Macaca mulatta prediction 9544 696874 - Ensembl:ENSMMUG00000019679 4 - autophagy related 5 protein-coding - mml-miR-30b predicted by miR-30a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22395361),(22617440),(22902544),(23274497),(24148619) 3002 mml-miR-519d miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006387 miRNA MAP1LC3B autophagy down Macaca mulatta prediction 9544 695419 - Ensembl:ENSMMUG00000017613 20 - microtubule-associated protein 1 light chain 3 beta protein-coding - mml-miR-519d predicted by miR-20a (Homo sapiens), and MAP1LC3B predicted by MAP1LC3B (Homo sapiens) according to Pubmed ID (25485521) 3003 mml-miR-216b miR-216b/216b-5p MIMAT0006243 miRNA BECN1 autophagy down Macaca mulatta prediction 9544 711649 beclin-1 Ensembl:ENSMMUG00000029971 16 - beclin 1, autophagy related protein-coding - mml-miR-216b predicted by miR-216b (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (24681041) 3004 mml-miR-18b miR-18ab/4735-3p MIMAT0006163 miRNA ATM autophagy down Macaca mulatta prediction 9544 100427400 - Ensembl:ENSMMUG00000004153 14 - ataxia telangiectasia mutated protein-coding - mml-miR-18b predicted by miR-18a (Homo sapiens), and ATM predicted by ATM (Homo sapiens) according to Pubmed ID (23229340) 3005 mml-let-7f let-7/98/4458/4500 MIMAT0006156 miRNA OLR1 autophagy down Macaca mulatta prediction 9544 717596 - Ensembl:ENSMMUG00000002191 11 - oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding - mml-let-7f predicted by let-7g (Mus musculus), and OLR1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 3006 mml-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002772 miRNA HIF1A autophagy down Macaca mulatta prediction 9544 704678 - Ensembl:ENSMMUG00000021002 7 - hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding - mml-miR-106b predicted by miR-20a (Homo sapiens), and HIF1A predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 3007 mml-miR-29c miR-29abcd MIMAT0006169 miRNA ATG14 autophagy down Macaca mulatta prediction 9544 697252 - Ensembl:ENSMMUG00000003761 7 - autophagy related 14 protein-coding - mml-miR-29c predicted by miR-29b (Bos taurus), and ATG14 predicted by ATG14 (Bos taurus) according to Pubmed ID (25234643) 3008 mml-miR-373 miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0006299 miRNA SQSTM1 autophagy down Macaca mulatta prediction 9544 705481 - Ensembl:ENSMMUG00000021055 6 - sequestosome 1 protein-coding - mml-miR-373 predicted by miR-372 (Homo sapiens), and SQSTM1 predicted by SQSTM1 (Homo sapiens) according to Pubmed ID (24991827) 3009 mml-miR-30b miR-30abcdef/30abe-5p/384-5p MIMAT0002213 miRNA MAP1LC3B autophagy down Macaca mulatta prediction 9544 695419 - Ensembl:ENSMMUG00000017613 20 - microtubule-associated protein 1 light chain 3 beta protein-coding - mml-miR-30b predicted by miR-30a (Homo sapiens), and MAP1LC3B predicted by MAP1LC3B (Homo sapiens) according to Pubmed ID (22135297) 3010 mml-miR-99b miR-99ab/100 MIMAT0006179 miRNA IGF1R autophagy down Macaca mulatta prediction 9544 708227 - Ensembl:ENSMMUG00000012305 7 - insulin-like growth factor 1 receptor protein-coding - mml-miR-99b predicted by miR-100 (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25026290) 3011 mml-miR-25 miR-25/32/92abc/363/363-3p/367 MIMAT0002774 miRNA UVRAG autophagy down Macaca mulatta prediction 9544 696601 - Ensembl:ENSMMUG00000000187 14 - UV radiation resistance associated gene protein-coding - mml-miR-25 predicted by miR-32 (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22135297) 3012 mml-let-7b let-7/98/4458/4500 MIMAT0006152 miRNA IGF1R autophagy down Macaca mulatta prediction 9544 708227 - Ensembl:ENSMMUG00000012305 7 - insulin-like growth factor 1 receptor protein-coding - mml-let-7b predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 3013 mml-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006164 miRNA HIF1A autophagy down Macaca mulatta prediction 9544 704678 - Ensembl:ENSMMUG00000021002 7 - hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding - mml-miR-20b predicted by miR-20a (Homo sapiens), and HIF1A predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 3014 mml-miR-421 miR-421 MIMAT0006319 miRNA ATG2B autophagy down Macaca mulatta prediction 9544 712467 - - 7 - autophagy related 2B protein-coding - mml-miR-421 predicted by miR-421 (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (20371350) 3015 mml-miR-106a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002798 miRNA FYCO1 autophagy down Macaca mulatta prediction 9544 713756 - Ensembl:ENSMMUG00000023585 2 - FYVE and coiled-coil domain containing 1 protein-coding - mml-miR-106a predicted by miR-93 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3016 mml-miR-101 miR-101/101ab MIMAT0002431 miRNA ATG4D autophagy down Macaca mulatta prediction 9544 713111 - Ensembl:ENSMMUG00000011950 19 - autophagy related 4D, cysteine peptidase protein-coding - mml-miR-101 predicted by miR-101 (Homo sapiens), and ATG4D predicted by (Homo sapiens),ATG4D (Homo sapiens) according to Pubmed ID (21915098),(22085996),(22902544),(23483142) 3017 mml-miR-16 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0002651 miRNA ATG14 autophagy down Macaca mulatta prediction 9544 697252 - Ensembl:ENSMMUG00000003761 7 - autophagy related 14 protein-coding - mml-miR-16 predicted by miR-195 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 3018 mml-miR-454 miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0006338 miRNA FYCO1 autophagy down Macaca mulatta prediction 9544 713756 - Ensembl:ENSMMUG00000023585 2 - FYVE and coiled-coil domain containing 1 protein-coding - mml-miR-454 predicted by miR-130b (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3019 mml-miR-301a miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0006257 miRNA RB1CC1 autophagy down Macaca mulatta prediction 9544 710330 - Ensembl:ENSMMUG00000009990 8 - RB1-inducible coiled-coil 1 protein-coding - mml-miR-301a predicted by miR-133b (Homo sapiens), and RB1CC1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 3020 mml-miR-101 miR-101/101ab MIMAT0002431 miRNA RAB5A autophagy down Macaca mulatta prediction 9544 699014 - - X - RAB5A, member RAS oncogene family protein-coding - mml-miR-101 predicted by miR-101 (Homo sapiens), and RAB5A predicted by RAB5A (Homo sapiens) according to Pubmed ID (21915098),(23483142),(25606826) 3021 mml-miR-302b miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0006260 miRNA SQSTM1 autophagy down Macaca mulatta prediction 9544 705481 - Ensembl:ENSMMUG00000021055 6 - sequestosome 1 protein-coding - mml-miR-302b predicted by miR-372 (Homo sapiens), and SQSTM1 predicted by SQSTM1 (Homo sapiens) according to Pubmed ID (24991827) 3022 mml-miR-204 miR-204/204b/211 MIMAT0006235 miRNA LOC701870 autophagy down Macaca mulatta prediction 9544 701870 - - 2 - von Hippel-Lindau disease tumor suppressor-like protein-coding - mml-miR-204 predicted by miR-204 (Homo sapiens), and LOC701870 predicted by VHL (Homo sapiens) according to Pubmed ID (25517751) 3023 mml-miR-424 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0006323 miRNA ATG14 autophagy down Macaca mulatta prediction 9544 697252 - Ensembl:ENSMMUG00000003761 7 - autophagy related 14 protein-coding - mml-miR-424 predicted by miR-195 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 3024 mml-miR-92a miR-25/32/92abc/363/363-3p/367 MIMAT0002706 miRNA LOC709746 autophagy down Macaca mulatta prediction 9544 709746 - Ensembl:ENSMMUG00000015773 11 - serine/threonine-protein kinase ULK1-like protein-coding - mml-miR-92a predicted by miR-25 (Homo sapiens), and LOC709746 predicted by ULK1 (Homo sapiens) according to Pubmed ID (25026296) 3025 mml-miR-375 miR-375 MIMAT0006302 miRNA YWHAZ autophagy down Macaca mulatta prediction 9544 709723 - Ensembl:ENSMMUG00000006489 8 - tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide protein-coding - mml-miR-375 predicted by miR-375 (Homo sapiens), and YWHAZ predicted by YWHAZ (Homo sapiens) according to Pubmed ID (22606351) 3026 mml-let-7c let-7/98/4458/4500 MIMAT0006153 miRNA IGF1R autophagy down Macaca mulatta prediction 9544 708227 - Ensembl:ENSMMUG00000012305 7 - insulin-like growth factor 1 receptor protein-coding - mml-let-7c predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 3027 mml-miR-519a miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0006384 miRNA LOC709746 autophagy down Macaca mulatta prediction 9544 709746 - Ensembl:ENSMMUG00000015773 11 - serine/threonine-protein kinase ULK1-like protein-coding - mml-miR-519a predicted by miR-291 (Mus musculus), and LOC709746 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 3028 mml-miR-101 miR-101/101ab MIMAT0002431 miRNA EZH2 autophagy down Macaca mulatta prediction 9544 709075 - Ensembl:ENSMMUG00000013494 3 - enhancer of zeste homolog 2 (Drosophila) protein-coding - mml-miR-101 predicted by miR-101 (Homo sapiens), and EZH2 predicted by EZH2 (Homo sapiens) according to Pubmed ID (24211739) 3029 mml-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002772 miRNA SQSTM1 autophagy down Macaca mulatta prediction 9544 705481 - Ensembl:ENSMMUG00000021055 6 - sequestosome 1 protein-coding - mml-miR-106b predicted by miR-106b (Homo sapiens),miR-106 (Mus musculus), and SQSTM1 predicted by Sqstm1 (Mus musculus),SQSTM1 (Homo sapiens) according to Pubmed ID (21628417),(22441107),(25485521),(25617127) 3030 mml-miR-518a-3p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006378 miRNA MAP1LC3B autophagy down Macaca mulatta prediction 9544 695419 - Ensembl:ENSMMUG00000017613 20 - microtubule-associated protein 1 light chain 3 beta protein-coding - mml-miR-518a-3p predicted by miR-20a (Homo sapiens), and MAP1LC3B predicted by MAP1LC3B (Homo sapiens) according to Pubmed ID (25485521) 3031 mml-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002704 miRNA LOC709746 autophagy down Macaca mulatta prediction 9544 709746 - Ensembl:ENSMMUG00000015773 11 - serine/threonine-protein kinase ULK1-like protein-coding - mml-miR-20a predicted by miR-106b (Homo sapiens), and LOC709746 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 3032 mml-miR-199a miR-199ab-5p MIMAT0002531 miRNA BECN1 autophagy down Macaca mulatta prediction 9544 711649 beclin-1 Ensembl:ENSMMUG00000029971 16 - beclin 1, autophagy related protein-coding - mml-miR-199a predicted by miR-199a-5p (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (23337876) 3033 mml-miR-106a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002798 miRNA BECN1 autophagy down Macaca mulatta prediction 9544 711649 beclin-1 Ensembl:ENSMMUG00000029971 16 - beclin 1, autophagy related protein-coding - mml-miR-106a predicted by miR-17-5p (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (24755562),(25435430),(25485521) 3034 mml-miR-34c-5p miR-34ac/34bc-5p/449abc/449c-5p MIMAT0006175 miRNA LOC717813 autophagy down Macaca mulatta prediction 9544 717813 - - 12 - cysteine protease ATG4B-like protein-coding - mml-miR-34c-5p predicted by miR-34a (Homo sapiens), and LOC717813 predicted by ATG4B (Homo sapiens) according to Pubmed ID (24755409) 3035 mml-miR-106a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002798 miRNA LOC709746 autophagy down Macaca mulatta prediction 9544 709746 - Ensembl:ENSMMUG00000015773 11 - serine/threonine-protein kinase ULK1-like protein-coding - mml-miR-106a predicted by miR-106b (Homo sapiens), and LOC709746 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 3036 mml-miR-302a miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0006259 miRNA LOC709746 autophagy down Macaca mulatta prediction 9544 709746 - Ensembl:ENSMMUG00000015773 11 - serine/threonine-protein kinase ULK1-like protein-coding - mml-miR-302a predicted by miR-291 (Mus musculus), and LOC709746 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 3037 mml-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006164 miRNA LOC709746 autophagy down Macaca mulatta prediction 9544 709746 - Ensembl:ENSMMUG00000015773 11 - serine/threonine-protein kinase ULK1-like protein-coding - mml-miR-20b predicted by miR-106b (Homo sapiens), and LOC709746 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 3038 mml-miR-144 miR-144 MIMAT0006202 miRNA MAPK1 autophagy down Macaca mulatta prediction 9544 698569 - Ensembl:ENSMMUG00000012524 10 - mitogen-activated protein kinase 1 protein-coding - mml-miR-144 predicted by miR-144 (Homo sapiens), and MAPK1 predicted by MAPK1 (Homo sapiens) according to Pubmed ID (25060662) 3039 mml-miR-155 miR-155 MIMAT0006216 miRNA GABARAPL1 autophagy down Macaca mulatta prediction 9544 717640 - Ensembl:ENSMMUG00000002197 11 - GABA(A) receptor-associated protein like 1 protein-coding - mml-miR-155 predicted by miR-155 (Homo sapiens), and GABARAPL1 predicted by GABARAPL1 (Homo sapiens) according to Pubmed ID (20584899) 3040 mml-miR-155 miR-155 MIMAT0006216 miRNA ATG3 autophagy down Macaca mulatta prediction 9544 708305 - Ensembl:ENSMMUG00000014232 2 - autophagy related 3 protein-coding - mml-miR-155 predicted by miR-155 (Homo sapiens), and ATG3 predicted by ATG3 (Homo sapiens) according to Pubmed ID (22135297) 3041 mml-miR-130a miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0002235 miRNA RB1CC1 autophagy down Macaca mulatta prediction 9544 710330 - Ensembl:ENSMMUG00000009990 8 - RB1-inducible coiled-coil 1 protein-coding - mml-miR-130a predicted by miR-133b (Homo sapiens), and RB1CC1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 3042 mml-miR-181d miR-181abcd/4262 MIMAT0006217 miRNA UVRAG autophagy down Macaca mulatta prediction 9544 696601 - Ensembl:ENSMMUG00000000187 14 - UV radiation resistance associated gene protein-coding - mml-miR-181d predicted by miR-181a (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22356768) 3043 mml-miR-205 miR-205/205ab MIMAT0006236 miRNA RAB27A autophagy down Macaca mulatta prediction 9544 697741 - Ensembl:ENSMMUG00000020694 7 - RAB27A, member RAS oncogene family protein-coding - mml-miR-205 predicted by miR-205 (Homo sapiens), and RAB27A predicted by RAB27A (Homo sapiens) according to Pubmed ID (24370341) 3044 mml-miR-199a miR-199ab-5p MIMAT0002531 miRNA HSPA5 autophagy down Macaca mulatta prediction 9544 703193 - Ensembl:ENSMMUG00000005217 15 - heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) protein-coding - mml-miR-199a predicted by miR-199a-5p (Mus musculus), and HSPA5 predicted by Hspa5 (Mus musculus) according to Pubmed ID (23598416) 3045 mml-miR-144 miR-144 MIMAT0006202 miRNA GSK3B autophagy down Macaca mulatta prediction 9544 713114 - Ensembl:ENSMMUG00000001980 2 - glycogen synthase kinase 3 beta protein-coding - mml-miR-144 predicted by miR-144 (Homo sapiens), and GSK3B predicted by GSK3B (Homo sapiens) according to Pubmed ID (25060662) 3046 mml-miR-17-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002700 miRNA HIF1A autophagy down Macaca mulatta prediction 9544 704678 - Ensembl:ENSMMUG00000021002 7 - hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding - mml-miR-17-5p predicted by miR-20a (Homo sapiens), and HIF1A predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 3047 mml-miR-30c miR-30abcdef/30abe-5p/384-5p MIMAT0006170 miRNA BECN1 autophagy down Macaca mulatta prediction 9544 711649 beclin-1 Ensembl:ENSMMUG00000029971 16 - beclin 1, autophagy related protein-coding - mml-miR-30c predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and BECN1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 3048 mml-miR-99a miR-99ab/100 MIMAT0002410 miRNA IGF1R autophagy down Macaca mulatta prediction 9544 708227 - Ensembl:ENSMMUG00000012305 7 - insulin-like growth factor 1 receptor protein-coding - mml-miR-99a predicted by miR-100 (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25026290) 3049 mml-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002772 miRNA LOC709746 autophagy down Macaca mulatta prediction 9544 709746 - Ensembl:ENSMMUG00000015773 11 - serine/threonine-protein kinase ULK1-like protein-coding - mml-miR-106b predicted by miR-106b (Homo sapiens), and LOC709746 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 3050 mml-miR-17-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002700 miRNA ATG5 autophagy down Macaca mulatta prediction 9544 696874 - Ensembl:ENSMMUG00000019679 4 - autophagy related 5 protein-coding - mml-miR-17-5p predicted by miR-20a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (25485521) 3051 mml-miR-320 miR-320abcd/4429 MIMAT0006263 miRNA LOC709746 autophagy down Macaca mulatta prediction 9544 709746 - Ensembl:ENSMMUG00000015773 11 - serine/threonine-protein kinase ULK1-like protein-coding - mml-miR-320 predicted by miR-320a (Homo sapiens), and LOC709746 predicted by ULK1 (Homo sapiens) according to Pubmed ID (23622248) 3052 mml-miR-30e miR-30abcdef/30abe-5p/384-5p MIMAT0006172 miRNA BECN1 autophagy down Macaca mulatta prediction 9544 711649 beclin-1 Ensembl:ENSMMUG00000029971 16 - beclin 1, autophagy related protein-coding - mml-miR-30e predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and BECN1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 3053 mml-let-7c let-7/98/4458/4500 MIMAT0006153 miRNA OLR1 autophagy down Macaca mulatta prediction 9544 717596 - Ensembl:ENSMMUG00000002191 11 - oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding - mml-let-7c predicted by let-7g (Mus musculus), and OLR1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 3054 mml-miR-449a miR-34ac/34bc-5p/449abc/449c-5p MIMAT0006330 miRNA ATG9A autophagy down Macaca mulatta prediction 9544 702263 - Ensembl:ENSMMUG00000019619 12 - autophagy related 9A protein-coding - mml-miR-449a predicted by miR-34a (Homo sapiens),miR-34a (Rattus norvegicus), and ATG9A predicted by Atg9a (Rattus norvegicus),ATG9A (Homo sapiens) according to Pubmed ID (22902544),(24728149),(24973144) 3055 mml-let-7g let-7/98/4458/4500 MIMAT0006157 miRNA IGF1R autophagy down Macaca mulatta prediction 9544 708227 - Ensembl:ENSMMUG00000012305 7 - insulin-like growth factor 1 receptor protein-coding - mml-let-7g predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 3056 mml-miR-301a miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0006257 miRNA FYCO1 autophagy down Macaca mulatta prediction 9544 713756 - Ensembl:ENSMMUG00000023585 2 - FYVE and coiled-coil domain containing 1 protein-coding - mml-miR-301a predicted by miR-130b (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3057 mml-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002772 miRNA ATG5 autophagy down Macaca mulatta prediction 9544 696874 - Ensembl:ENSMMUG00000019679 4 - autophagy related 5 protein-coding - mml-miR-106b predicted by miR-20a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (25485521) 3058 mml-miR-142-3p miR-142-3p MIMAT0006200 miRNA ATG16L1 autophagy down Macaca mulatta prediction 9544 714092 - Ensembl:ENSMMUG00000023358 12 - autophagy related 16-like 1 (S. cerevisiae) protein-coding - mml-miR-142-3p predicted by miR-142-3p (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (24401604) 3059 mml-miR-30a-5p miR-30abcdef/30abe-5p/384-5p MIMAT0002369 miRNA MAP1LC3B autophagy down Macaca mulatta prediction 9544 695419 - Ensembl:ENSMMUG00000017613 20 - microtubule-associated protein 1 light chain 3 beta protein-coding - mml-miR-30a-5p predicted by miR-30a (Homo sapiens), and MAP1LC3B predicted by MAP1LC3B (Homo sapiens) according to Pubmed ID (22135297) 3060 mml-miR-130a miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0002235 miRNA ATG2B autophagy down Macaca mulatta prediction 9544 712467 - - 7 - autophagy related 2B protein-coding - mml-miR-130a predicted by miR-130a (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (22902544) 3061 mml-miR-130b miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0006187 miRNA ATG2B autophagy down Macaca mulatta prediction 9544 712467 - - 7 - autophagy related 2B protein-coding - mml-miR-130b predicted by miR-130a (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (22902544) 3062 mml-miR-212 miR-132/212/212-3p MIMAT0006241 miRNA FOXO3 autophagy down Macaca mulatta prediction 9544 700731 - - 4 - forkhead box O3 protein-coding - mml-miR-212 predicted by miR-132 (Mus musculus), and FOXO3 predicted by Foxo3 (Mus musculus) according to Pubmed ID (23011132) 3063 mml-miR-302c miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0006261 miRNA FYCO1 autophagy down Macaca mulatta prediction 9544 713756 - Ensembl:ENSMMUG00000023585 2 - FYVE and coiled-coil domain containing 1 protein-coding - mml-miR-302c predicted by miR-373 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3064 mml-miR-372 miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0006298 miRNA FYCO1 autophagy down Macaca mulatta prediction 9544 713756 - Ensembl:ENSMMUG00000023585 2 - FYVE and coiled-coil domain containing 1 protein-coding - mml-miR-372 predicted by miR-373 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3065 mml-miR-518a-3p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006378 miRNA ATG16L1 autophagy down Macaca mulatta prediction 9544 714092 - Ensembl:ENSMMUG00000023358 12 - autophagy related 16-like 1 (S. cerevisiae) protein-coding - mml-miR-518a-3p predicted by miR-106b (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 3066 mml-miR-155 miR-155 MIMAT0006216 miRNA RICTOR autophagy down Macaca mulatta prediction 9544 694915 - Ensembl:ENSMMUG00000001611 6 - RPTOR independent companion of MTOR, complex 2 protein-coding - mml-miR-155 predicted by miR-155 (Homo sapiens), and RICTOR predicted by RICTOR (Homo sapiens) according to Pubmed ID (24262949) 3067 mml-miR-374b miR-374ab MIMAT0006301 miRNA LOC711835 autophagy down Macaca mulatta prediction 9544 711835 - - 6 - autophagy-related protein 10-like protein-coding - mml-miR-374b predicted by miR-374a (Homo sapiens), and LOC711835 predicted by ATG10 (Homo sapiens) according to Pubmed ID (22356768) 3068 mml-miR-15b miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0002207 miRNA BAG5 autophagy down Macaca mulatta prediction 9544 699170 - Ensembl:ENSMMUG00000017005 7 - BCL2-associated athanogene 5 protein-coding - mml-miR-15b predicted by miR-16 (Mus musculus), and BAG5 predicted by Bag5 (Mus musculus) according to Pubmed ID (21770019) 3069 mml-miR-30c miR-30abcdef/30abe-5p/384-5p MIMAT0006170 miRNA ATG2B autophagy down Macaca mulatta prediction 9544 712467 - - 7 - autophagy related 2B protein-coding - mml-miR-30c predicted by mir-30d (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (23274497) 3070 mml-miR-92b miR-25/32/92abc/363/363-3p/367 MIMAT0006177 miRNA UVRAG autophagy down Macaca mulatta prediction 9544 696601 - Ensembl:ENSMMUG00000000187 14 - UV radiation resistance associated gene protein-coding - mml-miR-92b predicted by miR-32 (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22135297) 3071 mml-miR-199a-5p miR-199ab-5p MIMAT0006231 miRNA BECN1 autophagy down Macaca mulatta prediction 9544 711649 beclin-1 Ensembl:ENSMMUG00000029971 16 - beclin 1, autophagy related protein-coding - mml-miR-199a-5p predicted by miR-199a-5p (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (23337876) 3072 mml-miR-302a miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0006259 miRNA SQSTM1 autophagy down Macaca mulatta prediction 9544 705481 - Ensembl:ENSMMUG00000021055 6 - sequestosome 1 protein-coding - mml-miR-302a predicted by miR-372 (Homo sapiens), and SQSTM1 predicted by SQSTM1 (Homo sapiens) according to Pubmed ID (24991827) 3073 mml-miR-374a miR-374ab MIMAT0006300 miRNA UVRAG autophagy down Macaca mulatta prediction 9544 696601 - Ensembl:ENSMMUG00000000187 14 - UV radiation resistance associated gene protein-coding - mml-miR-374a predicted by miR-374a (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22356768) 3074 mml-miR-302b miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0006260 miRNA FYCO1 autophagy down Macaca mulatta prediction 9544 713756 - Ensembl:ENSMMUG00000023585 2 - FYVE and coiled-coil domain containing 1 protein-coding - mml-miR-302b predicted by miR-373 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3075 mml-miR-363 miR-25/32/92abc/363/363-3p/367 MIMAT0006290 miRNA LOC709746 autophagy down Macaca mulatta prediction 9544 709746 - Ensembl:ENSMMUG00000015773 11 - serine/threonine-protein kinase ULK1-like protein-coding - mml-miR-363 predicted by miR-25 (Homo sapiens), and LOC709746 predicted by ULK1 (Homo sapiens) according to Pubmed ID (25026296) 3076 mml-miR-449b miR-34ac/34bc-5p/449abc/449c-5p MIMAT0006331 miRNA LOC717813 autophagy down Macaca mulatta prediction 9544 717813 - - 12 - cysteine protease ATG4B-like protein-coding - mml-miR-449b predicted by miR-34a (Homo sapiens), and LOC717813 predicted by ATG4B (Homo sapiens) according to Pubmed ID (24755409) 3077 mml-miR-181d miR-181abcd/4262 MIMAT0006217 miRNA TP63 autophagy down Macaca mulatta prediction 9544 703997 - Ensembl:ENSMMUG00000016466 2 - tumor protein p63 protein-coding - mml-miR-181d predicted by miR-181a (Homo sapiens), and TP63 predicted by TP63 (Homo sapiens) according to Pubmed ID (22356768) 3078 mml-miR-301b miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0006258 miRNA ATG2B autophagy down Macaca mulatta prediction 9544 712467 - - 7 - autophagy related 2B protein-coding - mml-miR-301b predicted by miR-130a (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (22902544) 3079 mml-miR-98 let-7/98/4458/4500 MIMAT0002404 miRNA IGF1R autophagy down Macaca mulatta prediction 9544 708227 - Ensembl:ENSMMUG00000012305 7 - insulin-like growth factor 1 receptor protein-coding - mml-miR-98 predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 3080 mml-miR-199a-5p miR-199ab-5p MIMAT0006231 miRNA DRAM1 autophagy down Macaca mulatta prediction 9544 697427 DRAM Ensembl:ENSMMUG00000004689 11 - DNA-damage regulated autophagy modulator 1 protein-coding - mml-miR-199a-5p predicted by miR-199a-5p (Homo sapiens), and DRAM1 predicted by DRAM1 (Homo sapiens) according to Pubmed ID (23337876) 3081 mml-miR-155 miR-155 MIMAT0006216 miRNA GSK3B autophagy down Macaca mulatta prediction 9544 713114 - Ensembl:ENSMMUG00000001980 2 - glycogen synthase kinase 3 beta protein-coding - mml-miR-155 predicted by miR-155 (Homo sapiens), and GSK3B predicted by GSK3B (Homo sapiens) according to Pubmed ID (24343269) 3082 mml-miR-372 miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0006298 miRNA SQSTM1 autophagy down Macaca mulatta prediction 9544 705481 - Ensembl:ENSMMUG00000021055 6 - sequestosome 1 protein-coding - mml-miR-372 predicted by miR-372 (Homo sapiens), and SQSTM1 predicted by SQSTM1 (Homo sapiens) according to Pubmed ID (24991827) 3083 mml-let-7g let-7/98/4458/4500 MIMAT0006157 miRNA OLR1 autophagy down Macaca mulatta prediction 9544 717596 - Ensembl:ENSMMUG00000002191 11 - oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding - mml-let-7g predicted by let-7g (Mus musculus), and OLR1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 3084 mml-miR-520a miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0006388 miRNA FYCO1 autophagy down Macaca mulatta prediction 9544 713756 - Ensembl:ENSMMUG00000023585 2 - FYVE and coiled-coil domain containing 1 protein-coding - mml-miR-520a predicted by miR-373 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3085 mml-miR-449b miR-34ac/34bc-5p/449abc/449c-5p MIMAT0006331 miRNA ATG9A autophagy down Macaca mulatta prediction 9544 702263 - Ensembl:ENSMMUG00000019619 12 - autophagy related 9A protein-coding - mml-miR-449b predicted by miR-34a (Homo sapiens),miR-34a (Rattus norvegicus), and ATG9A predicted by Atg9a (Rattus norvegicus),ATG9A (Homo sapiens) according to Pubmed ID (22902544),(24728149),(24973144) 3086 mml-miR-519d miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006387 miRNA LOC709746 autophagy down Macaca mulatta prediction 9544 709746 - Ensembl:ENSMMUG00000015773 11 - serine/threonine-protein kinase ULK1-like protein-coding - mml-miR-519d predicted by miR-106b (Homo sapiens), and LOC709746 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 3087 mml-miR-335 miR-335/335-5p MIMAT0006274 miRNA ATG16L2 autophagy down Macaca mulatta prediction 9544 717952 - Ensembl:ENSMMUG00000001293 14 - autophagy related 16-like 2 (S. cerevisiae) protein-coding - mml-miR-335 predicted by miR-335 (Homo sapiens), and ATG16L2 predicted by ATG16L2 (Homo sapiens) according to Pubmed ID (18185580) 3088 mml-miR-301b miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0006258 miRNA RB1CC1 autophagy down Macaca mulatta prediction 9544 710330 - Ensembl:ENSMMUG00000009990 8 - RB1-inducible coiled-coil 1 protein-coding - mml-miR-301b predicted by miR-133b (Homo sapiens), and RB1CC1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 3089 mml-miR-15b miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0002207 miRNA ATG14 autophagy down Macaca mulatta prediction 9544 697252 - Ensembl:ENSMMUG00000003761 7 - autophagy related 14 protein-coding - mml-miR-15b predicted by miR-195 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 3090 mml-miR-30d miR-30abcdef/30abe-5p/384-5p MIMAT0006171 miRNA MAP1LC3B autophagy down Macaca mulatta prediction 9544 695419 - Ensembl:ENSMMUG00000017613 20 - microtubule-associated protein 1 light chain 3 beta protein-coding - mml-miR-30d predicted by miR-30a (Homo sapiens), and MAP1LC3B predicted by MAP1LC3B (Homo sapiens) according to Pubmed ID (22135297) 3091 mml-miR-182 miR-182 MIMAT0002513 miRNA FOXO3 autophagy down Macaca mulatta prediction 9544 700731 - - 4 - forkhead box O3 protein-coding - mml-miR-182 predicted by miR-182 (Homo sapiens), and FOXO3 predicted by FOXO3 (Homo sapiens) according to Pubmed ID (24871856) 3092 mml-miR-204 miR-204/204b/211 MIMAT0006235 miRNA TRPM3 autophagy down Macaca mulatta prediction 9544 702898 - Ensembl:ENSMMUG00000006156 15 - transient receptor potential cation channel, subfamily M, member 3 protein-coding - mml-miR-204 predicted by miR-204 (Homo sapiens), and TRPM3 predicted by TRPM3 (Homo sapiens) according to Pubmed ID (25517751) 3093 mml-miR-96 miR-96/507/1271 MIMAT0002784 miRNA ATG7 autophagy down Macaca mulatta prediction 9544 696238 - Ensembl:ENSMMUG00000021804 2 - autophagy related 7 protein-coding - mml-miR-96 predicted by miR-96 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (25333253) 3094 mml-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006164 miRNA SQSTM1 autophagy down Macaca mulatta prediction 9544 705481 - Ensembl:ENSMMUG00000021055 6 - sequestosome 1 protein-coding - mml-miR-20b predicted by miR-106b (Homo sapiens),miR-106 (Mus musculus), and SQSTM1 predicted by Sqstm1 (Mus musculus),SQSTM1 (Homo sapiens) according to Pubmed ID (21628417),(22441107),(25485521),(25617127) 3095 mml-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002772 miRNA ATG16L1 autophagy down Macaca mulatta prediction 9544 714092 - Ensembl:ENSMMUG00000023358 12 - autophagy related 16-like 1 (S. cerevisiae) protein-coding - mml-miR-106b predicted by miR-106b (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 3096 mml-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002704 miRNA BECN1 autophagy down Macaca mulatta prediction 9544 711649 beclin-1 Ensembl:ENSMMUG00000029971 16 - beclin 1, autophagy related protein-coding - mml-miR-20a predicted by miR-17-5p (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (24755562),(25435430),(25485521) 3097 mml-miR-130b miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0006187 miRNA FYCO1 autophagy down Macaca mulatta prediction 9544 713756 - Ensembl:ENSMMUG00000023585 2 - FYVE and coiled-coil domain containing 1 protein-coding - mml-miR-130b predicted by miR-130b (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3098 mml-miR-367 miR-25/32/92abc/363/363-3p/367 MIMAT0006292 miRNA LOC709746 autophagy down Macaca mulatta prediction 9544 709746 - Ensembl:ENSMMUG00000015773 11 - serine/threonine-protein kinase ULK1-like protein-coding - mml-miR-367 predicted by miR-25 (Homo sapiens), and LOC709746 predicted by ULK1 (Homo sapiens) according to Pubmed ID (25026296) 3099 mml-miR-424 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0006323 miRNA BAG5 autophagy down Macaca mulatta prediction 9544 699170 - Ensembl:ENSMMUG00000017005 7 - BCL2-associated athanogene 5 protein-coding - mml-miR-424 predicted by miR-16 (Mus musculus), and BAG5 predicted by Bag5 (Mus musculus) according to Pubmed ID (21770019) 3100 mml-let-7a let-7/98/4458/4500 MIMAT0006151 miRNA IGF1R autophagy down Macaca mulatta prediction 9544 708227 - Ensembl:ENSMMUG00000012305 7 - insulin-like growth factor 1 receptor protein-coding - mml-let-7a predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 3101 mml-miR-17-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002700 miRNA LOC709746 autophagy down Macaca mulatta prediction 9544 709746 - Ensembl:ENSMMUG00000015773 11 - serine/threonine-protein kinase ULK1-like protein-coding - mml-miR-17-5p predicted by miR-106b (Homo sapiens), and LOC709746 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 3102 mml-miR-302d miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0006262 miRNA FYCO1 autophagy down Macaca mulatta prediction 9544 713756 - Ensembl:ENSMMUG00000023585 2 - FYVE and coiled-coil domain containing 1 protein-coding - mml-miR-302d predicted by miR-373 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3103 mml-miR-302d miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0006262 miRNA ATG7 autophagy down Macaca mulatta prediction 9544 696238 - Ensembl:ENSMMUG00000021804 2 - autophagy related 7 protein-coding - mml-miR-302d predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 3104 mml-miR-518a-3p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006378 miRNA FYCO1 autophagy down Macaca mulatta prediction 9544 713756 - Ensembl:ENSMMUG00000023585 2 - FYVE and coiled-coil domain containing 1 protein-coding - mml-miR-518a-3p predicted by miR-93 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3105 mml-miR-34a miR-34ac/34bc-5p/449abc/449c-5p MIMAT0002499 miRNA LOC717813 autophagy down Macaca mulatta prediction 9544 717813 - - 12 - cysteine protease ATG4B-like protein-coding - mml-miR-34a predicted by miR-34a (Homo sapiens), and LOC717813 predicted by ATG4B (Homo sapiens) according to Pubmed ID (24755409) 3106 mml-miR-199a-5p miR-199ab-5p MIMAT0006231 miRNA HSPA5 autophagy down Macaca mulatta prediction 9544 703193 - Ensembl:ENSMMUG00000005217 15 - heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) protein-coding - mml-miR-199a-5p predicted by miR-199a-5p (Mus musculus), and HSPA5 predicted by Hspa5 (Mus musculus) according to Pubmed ID (23598416) 3107 mml-miR-32 miR-25/32/92abc/363/363-3p/367 MIMAT0002385 miRNA LOC709746 autophagy down Macaca mulatta prediction 9544 709746 - Ensembl:ENSMMUG00000015773 11 - serine/threonine-protein kinase ULK1-like protein-coding - mml-miR-32 predicted by miR-25 (Homo sapiens), and LOC709746 predicted by ULK1 (Homo sapiens) according to Pubmed ID (25026296) 3108 mml-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002772 miRNA FYCO1 autophagy down Macaca mulatta prediction 9544 713756 - Ensembl:ENSMMUG00000023585 2 - FYVE and coiled-coil domain containing 1 protein-coding - mml-miR-106b predicted by miR-93 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3109 mml-miR-372 miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0006298 miRNA LOC709746 autophagy down Macaca mulatta prediction 9544 709746 - Ensembl:ENSMMUG00000015773 11 - serine/threonine-protein kinase ULK1-like protein-coding - mml-miR-372 predicted by miR-291 (Mus musculus), and LOC709746 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 3110 mml-miR-211 miR-204/204b/211 MIMAT0002547 miRNA CAV1 autophagy down Macaca mulatta prediction 9544 704449 - - 3 - caveolin 1, caveolae protein, 22kDa protein-coding - mml-miR-211 predicted by miR-204 (Homo sapiens), and CAV1 predicted by CAV1 (Homo sapiens) according to Pubmed ID (25517751) 3111 mml-miR-30b miR-30abcdef/30abe-5p/384-5p MIMAT0002213 miRNA BNIP3L autophagy down Macaca mulatta prediction 9544 641440 - Ensembl:ENSMMUG00000023646 8 - BCL2/adenovirus E1B 19kDa interacting protein 3-like protein-coding - mml-miR-30b predicted by miR-30d (Homo sapiens), and BNIP3L predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 3112 mml-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002704 miRNA ATG16L1 autophagy down Macaca mulatta prediction 9544 714092 - Ensembl:ENSMMUG00000023358 12 - autophagy related 16-like 1 (S. cerevisiae) protein-coding - mml-miR-20a predicted by miR-106b (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 3113 mml-miR-100 miR-99ab/100 MIMAT0002422 miRNA IGF1R autophagy down Macaca mulatta prediction 9544 708227 - Ensembl:ENSMMUG00000012305 7 - insulin-like growth factor 1 receptor protein-coding - mml-miR-100 predicted by miR-100 (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25026290) 3114 mml-miR-302b miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0006260 miRNA ATG7 autophagy down Macaca mulatta prediction 9544 696238 - Ensembl:ENSMMUG00000021804 2 - autophagy related 7 protein-coding - mml-miR-302b predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 3115 mml-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006164 miRNA IRS4 autophagy down Macaca mulatta prediction 9544 707870 - Ensembl:ENSMMUG00000019467 12 - insulin receptor substrate 1-like protein-coding - mml-miR-20b predicted by miR-17 (Mus musculus), and IRS4 predicted by Irs1 (Mus musculus) according to Pubmed ID (25077541) 3116 mml-miR-211 miR-204/204b/211 MIMAT0002547 miRNA LOC701870 autophagy down Macaca mulatta prediction 9544 701870 - - 2 - von Hippel-Lindau disease tumor suppressor-like protein-coding - mml-miR-211 predicted by miR-204 (Homo sapiens), and LOC701870 predicted by VHL (Homo sapiens) according to Pubmed ID (25517751) 3117 mml-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002704 miRNA SQSTM1 autophagy down Macaca mulatta prediction 9544 705481 - Ensembl:ENSMMUG00000021055 6 - sequestosome 1 protein-coding - mml-miR-20a predicted by miR-106b (Homo sapiens),miR-106 (Mus musculus), and SQSTM1 predicted by Sqstm1 (Mus musculus),SQSTM1 (Homo sapiens) according to Pubmed ID (21628417),(22441107),(25485521),(25617127) 3118 mml-miR-25 miR-25/32/92abc/363/363-3p/367 MIMAT0002774 miRNA LOC709746 autophagy down Macaca mulatta prediction 9544 709746 - Ensembl:ENSMMUG00000015773 11 - serine/threonine-protein kinase ULK1-like protein-coding - mml-miR-25 predicted by miR-25 (Homo sapiens), and LOC709746 predicted by ULK1 (Homo sapiens) according to Pubmed ID (25026296) 3119 mml-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002772 miRNA IRS4 autophagy down Macaca mulatta prediction 9544 707870 - Ensembl:ENSMMUG00000019467 12 - insulin receptor substrate 1-like protein-coding - mml-miR-106b predicted by miR-17 (Mus musculus), and IRS4 predicted by Irs1 (Mus musculus) according to Pubmed ID (25077541) 3120 mml-miR-106a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002798 miRNA SQSTM1 autophagy down Macaca mulatta prediction 9544 705481 - Ensembl:ENSMMUG00000021055 6 - sequestosome 1 protein-coding - mml-miR-106a predicted by miR-106b (Homo sapiens),miR-106 (Mus musculus), and SQSTM1 predicted by Sqstm1 (Mus musculus),SQSTM1 (Homo sapiens) according to Pubmed ID (21628417),(22441107),(25485521),(25617127) 3121 mml-miR-30a-5p miR-30abcdef/30abe-5p/384-5p MIMAT0002369 miRNA BNIP3L autophagy down Macaca mulatta prediction 9544 641440 - Ensembl:ENSMMUG00000023646 8 - BCL2/adenovirus E1B 19kDa interacting protein 3-like protein-coding - mml-miR-30a-5p predicted by miR-30d (Homo sapiens), and BNIP3L predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 3122 mml-miR-30d miR-30abcdef/30abe-5p/384-5p MIMAT0006171 miRNA ATG2B autophagy down Macaca mulatta prediction 9544 712467 - - 7 - autophagy related 2B protein-coding - mml-miR-30d predicted by mir-30d (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (23274497) 3123 mml-miR-519d miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006387 miRNA ATG5 autophagy down Macaca mulatta prediction 9544 696874 - Ensembl:ENSMMUG00000019679 4 - autophagy related 5 protein-coding - mml-miR-519d predicted by miR-20a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (25485521) 3124 mml-miR-29c miR-29abcd MIMAT0006169 miRNA LOC716580 autophagy down Macaca mulatta prediction 9544 716580 - Ensembl:ENSMMUG00000008104 13 - proteasome activator complex subunit 4-like protein-coding - mml-miR-29c predicted by miR-29b (Homo sapiens), and LOC716580 predicted by PSME4 (Homo sapiens) according to Pubmed ID (25234165) 3125 mml-miR-92a miR-25/32/92abc/363/363-3p/367 MIMAT0002706 miRNA UVRAG autophagy down Macaca mulatta prediction 9544 696601 - Ensembl:ENSMMUG00000000187 14 - UV radiation resistance associated gene protein-coding - mml-miR-92a predicted by miR-32 (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22135297) 3126 mml-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002704 miRNA MAP1LC3B autophagy down Macaca mulatta prediction 9544 695419 - Ensembl:ENSMMUG00000017613 20 - microtubule-associated protein 1 light chain 3 beta protein-coding - mml-miR-20a predicted by miR-20a (Homo sapiens), and MAP1LC3B predicted by MAP1LC3B (Homo sapiens) according to Pubmed ID (25485521) 3127 mml-miR-363 miR-25/32/92abc/363/363-3p/367 MIMAT0006290 miRNA UVRAG autophagy down Macaca mulatta prediction 9544 696601 - Ensembl:ENSMMUG00000000187 14 - UV radiation resistance associated gene protein-coding - mml-miR-363 predicted by miR-32 (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22135297) 3128 mml-miR-32 miR-25/32/92abc/363/363-3p/367 MIMAT0002385 miRNA UVRAG autophagy down Macaca mulatta prediction 9544 696601 - Ensembl:ENSMMUG00000000187 14 - UV radiation resistance associated gene protein-coding - mml-miR-32 predicted by miR-32 (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22135297) 3129 mml-miR-520a miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0006388 miRNA LOC709746 autophagy down Macaca mulatta prediction 9544 709746 - Ensembl:ENSMMUG00000015773 11 - serine/threonine-protein kinase ULK1-like protein-coding - mml-miR-520a predicted by miR-291 (Mus musculus), and LOC709746 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 3130 mml-miR-548a miR-200bc/429/548a MIMAT0006410 miRNA HMOX1 autophagy down Macaca mulatta prediction 9544 719266 - Ensembl:ENSMMUG00000007221 10 - heme oxygenase (decycling) 1 protein-coding - mml-miR-548a predicted by miR-200c (Homo sapiens), and HMOX1 predicted by HMOX1 (Homo sapiens) according to Pubmed ID (25150313) 3131 mml-miR-301b miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0006258 miRNA FYCO1 autophagy down Macaca mulatta prediction 9544 713756 - Ensembl:ENSMMUG00000023585 2 - FYVE and coiled-coil domain containing 1 protein-coding - mml-miR-301b predicted by miR-130b (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3132 mml-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002704 miRNA FYCO1 autophagy down Macaca mulatta prediction 9544 713756 - Ensembl:ENSMMUG00000023585 2 - FYVE and coiled-coil domain containing 1 protein-coding - mml-miR-20a predicted by miR-93 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3133 mml-miR-106a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002798 miRNA HIF1A autophagy down Macaca mulatta prediction 9544 704678 - Ensembl:ENSMMUG00000021002 7 - hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding - mml-miR-106a predicted by miR-20a (Homo sapiens), and HIF1A predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 3134 mml-miR-335 miR-335/335-5p MIMAT0006274 miRNA ULK2 autophagy down Macaca mulatta prediction 9544 710708 - Ensembl:ENSMMUG00000021156 16 - unc-51-like kinase 2 (C. elegans) protein-coding - mml-miR-335 predicted by miR-335 (Homo sapiens), and ULK2 predicted by ULK2 (Homo sapiens) according to Pubmed ID (18185580) 3135 mml-let-7e let-7/98/4458/4500 MIMAT0006155 miRNA IGF1R autophagy down Macaca mulatta prediction 9544 708227 - Ensembl:ENSMMUG00000012305 7 - insulin-like growth factor 1 receptor protein-coding - mml-let-7e predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 3136 mml-miR-34c-5p miR-34ac/34bc-5p/449abc/449c-5p MIMAT0006175 miRNA ATG9A autophagy down Macaca mulatta prediction 9544 702263 - Ensembl:ENSMMUG00000019619 12 - autophagy related 9A protein-coding - mml-miR-34c-5p predicted by miR-34a (Homo sapiens),miR-34a (Rattus norvegicus), and ATG9A predicted by Atg9a (Rattus norvegicus),ATG9A (Homo sapiens) according to Pubmed ID (22902544),(24728149),(24973144) 3137 mml-miR-449a miR-34ac/34bc-5p/449abc/449c-5p MIMAT0006330 miRNA LOC717813 autophagy down Macaca mulatta prediction 9544 717813 - - 12 - cysteine protease ATG4B-like protein-coding - mml-miR-449a predicted by miR-34a (Homo sapiens), and LOC717813 predicted by ATG4B (Homo sapiens) according to Pubmed ID (24755409) 3138 mml-miR-93 miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0002773 miRNA LOC709746 autophagy down Macaca mulatta prediction 9544 709746 - Ensembl:ENSMMUG00000015773 11 - serine/threonine-protein kinase ULK1-like protein-coding - mml-miR-93 predicted by miR-291 (Mus musculus), and LOC709746 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 3139 mml-miR-93 miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0002773 miRNA ATG7 autophagy down Macaca mulatta prediction 9544 696238 - Ensembl:ENSMMUG00000021804 2 - autophagy related 7 protein-coding - mml-miR-93 predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 3140 mml-miR-302c miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0006261 miRNA LOC709746 autophagy down Macaca mulatta prediction 9544 709746 - Ensembl:ENSMMUG00000015773 11 - serine/threonine-protein kinase ULK1-like protein-coding - mml-miR-302c predicted by miR-291 (Mus musculus), and LOC709746 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 3141 mml-miR-17-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002700 miRNA FYCO1 autophagy down Macaca mulatta prediction 9544 713756 - Ensembl:ENSMMUG00000023585 2 - FYVE and coiled-coil domain containing 1 protein-coding - mml-miR-17-5p predicted by miR-93 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3142 mml-miR-30a-5p miR-30abcdef/30abe-5p/384-5p MIMAT0002369 miRNA ATG5 autophagy down Macaca mulatta prediction 9544 696874 - Ensembl:ENSMMUG00000019679 4 - autophagy related 5 protein-coding - mml-miR-30a-5p predicted by miR-30a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22395361),(22617440),(22902544),(23274497),(24148619) 3143 mml-let-7d let-7/98/4458/4500 MIMAT0006154 miRNA IGF1R autophagy down Macaca mulatta prediction 9544 708227 - Ensembl:ENSMMUG00000012305 7 - insulin-like growth factor 1 receptor protein-coding - mml-let-7d predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 3144 mml-miR-204 miR-204/204b/211 MIMAT0006235 miRNA CAV1 autophagy down Macaca mulatta prediction 9544 704449 - - 3 - caveolin 1, caveolae protein, 22kDa protein-coding - mml-miR-204 predicted by miR-204 (Homo sapiens), and CAV1 predicted by CAV1 (Homo sapiens) according to Pubmed ID (25517751) 3145 mml-let-7e let-7/98/4458/4500 MIMAT0006155 miRNA OLR1 autophagy down Macaca mulatta prediction 9544 717596 - Ensembl:ENSMMUG00000002191 11 - oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding - mml-let-7e predicted by let-7g (Mus musculus), and OLR1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 3146 mml-miR-101 miR-101/101ab MIMAT0002431 miRNA STMN1 autophagy down Macaca mulatta prediction 9544 719733 - - 1 - stathmin 1 protein-coding - mml-miR-101 predicted by miR-101 (Homo sapiens), and STMN1 predicted by STMN1 (Homo sapiens) according to Pubmed ID (21915098),(23483142),(25607713) 3147 mml-miR-143 miR-143/1721/4770 MIMAT0006201 miRNA ATG2B autophagy down Macaca mulatta prediction 9544 712467 - - 7 - autophagy related 2B protein-coding - mml-miR-143 predicted by miR-143 (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (25322940) 3148 mml-miR-17-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002700 miRNA SQSTM1 autophagy down Macaca mulatta prediction 9544 705481 - Ensembl:ENSMMUG00000021055 6 - sequestosome 1 protein-coding - mml-miR-17-5p predicted by miR-106b (Homo sapiens),miR-106 (Mus musculus), and SQSTM1 predicted by Sqstm1 (Mus musculus),SQSTM1 (Homo sapiens) according to Pubmed ID (21628417),(22441107),(25485521),(25617127) 3149 mml-miR-518a-3p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006378 miRNA BECN1 autophagy down Macaca mulatta prediction 9544 711649 beclin-1 Ensembl:ENSMMUG00000029971 16 - beclin 1, autophagy related protein-coding - mml-miR-518a-3p predicted by miR-17-5p (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (24755562),(25435430),(25485521) 3150 mml-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002772 miRNA MAP1LC3B autophagy down Macaca mulatta prediction 9544 695419 - Ensembl:ENSMMUG00000017613 20 - microtubule-associated protein 1 light chain 3 beta protein-coding - mml-miR-106b predicted by miR-20a (Homo sapiens), and MAP1LC3B predicted by MAP1LC3B (Homo sapiens) according to Pubmed ID (25485521) 3151 mml-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002772 miRNA BECN1 autophagy down Macaca mulatta prediction 9544 711649 beclin-1 Ensembl:ENSMMUG00000029971 16 - beclin 1, autophagy related protein-coding - mml-miR-106b predicted by miR-17-5p (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (24755562),(25435430),(25485521) 3152 mml-miR-518a-3p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006378 miRNA ATG5 autophagy down Macaca mulatta prediction 9544 696874 - Ensembl:ENSMMUG00000019679 4 - autophagy related 5 protein-coding - mml-miR-518a-3p predicted by miR-20a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (25485521) 3153 mml-miR-216a miR-216a MIMAT0006242 miRNA BECN1 autophagy down Macaca mulatta prediction 9544 711649 beclin-1 Ensembl:ENSMMUG00000029971 16 - beclin 1, autophagy related protein-coding - mml-miR-216a predicted by miR-216a (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (24481443) 3154 mml-miR-17-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002700 miRNA ATG16L1 autophagy down Macaca mulatta prediction 9544 714092 - Ensembl:ENSMMUG00000023358 12 - autophagy related 16-like 1 (S. cerevisiae) protein-coding - mml-miR-17-5p predicted by miR-106b (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 3155 mml-miR-21 miR-21/590-5p MIMAT0002320 miRNA PTEN autophagy down Macaca mulatta prediction 9544 720411 - - 10 - phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like pseudo - mml-miR-21 predicted by miR-21 (Rattus norvegicus), and PTEN predicted by Pten (Rattus norvegicus) according to Pubmed ID (25689721) 3156 mml-miR-30d miR-30abcdef/30abe-5p/384-5p MIMAT0006171 miRNA BECN1 autophagy down Macaca mulatta prediction 9544 711649 beclin-1 Ensembl:ENSMMUG00000029971 16 - beclin 1, autophagy related protein-coding - mml-miR-30d predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and BECN1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 3157 mml-miR-195 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0006228 miRNA BAG5 autophagy down Macaca mulatta prediction 9544 699170 - Ensembl:ENSMMUG00000017005 7 - BCL2-associated athanogene 5 protein-coding - mml-miR-195 predicted by miR-16 (Mus musculus), and BAG5 predicted by Bag5 (Mus musculus) according to Pubmed ID (21770019) 3158 mml-miR-451 miR-451 MIMAT0006335 miRNA TSC1 autophagy down Macaca mulatta prediction 9544 714645 - - 15 - tuberous sclerosis 1 protein-coding - mml-miR-451 predicted by miR-451 (Homo sapiens), and TSC1 predicted by TSC1 (Homo sapiens) according to Pubmed ID (25209900) 3159 mml-miR-17-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002700 miRNA MAP1LC3B autophagy down Macaca mulatta prediction 9544 695419 - Ensembl:ENSMMUG00000017613 20 - microtubule-associated protein 1 light chain 3 beta protein-coding - mml-miR-17-5p predicted by miR-20a (Homo sapiens), and MAP1LC3B predicted by MAP1LC3B (Homo sapiens) according to Pubmed ID (25485521) 3160 mml-miR-181c miR-181abcd/4262 MIMAT0002509 miRNA TP63 autophagy down Macaca mulatta prediction 9544 703997 - Ensembl:ENSMMUG00000016466 2 - tumor protein p63 protein-coding - mml-miR-181c predicted by miR-181a (Homo sapiens), and TP63 predicted by TP63 (Homo sapiens) according to Pubmed ID (22356768) 3161 mml-miR-520a miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0006388 miRNA ATG7 autophagy down Macaca mulatta prediction 9544 696238 - Ensembl:ENSMMUG00000021804 2 - autophagy related 7 protein-coding - mml-miR-520a predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 3162 mml-miR-519d miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006387 miRNA ATG7 autophagy down Macaca mulatta prediction 9544 696238 - Ensembl:ENSMMUG00000021804 2 - autophagy related 7 protein-coding - mml-miR-519d predicted by miR-17 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 3163 mml-miR-130a miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0002235 miRNA FYCO1 autophagy down Macaca mulatta prediction 9544 713756 - Ensembl:ENSMMUG00000023585 2 - FYVE and coiled-coil domain containing 1 protein-coding - mml-miR-130a predicted by miR-130b (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3164 mml-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006164 miRNA ATG7 autophagy down Macaca mulatta prediction 9544 696238 - Ensembl:ENSMMUG00000021804 2 - autophagy related 7 protein-coding - mml-miR-20b predicted by miR-17 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 3165 mml-miR-22 miR-22/22-3p MIMAT0002330 miRNA BTG1 autophagy down Macaca mulatta prediction 9544 710112 - - 11 - B-cell translocation gene 1, anti-proliferative protein-coding - mml-miR-22 predicted by miR-22 (Homo sapiens), and BTG1 predicted by BTG1 (Homo sapiens) according to Pubmed ID (25449431) 3166 mml-miR-518a-3p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006378 miRNA LOC709746 autophagy down Macaca mulatta prediction 9544 709746 - Ensembl:ENSMMUG00000015773 11 - serine/threonine-protein kinase ULK1-like protein-coding - mml-miR-518a-3p predicted by miR-106b (Homo sapiens), and LOC709746 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 3167 mml-miR-30c miR-30abcdef/30abe-5p/384-5p MIMAT0006170 miRNA BNIP3L autophagy down Macaca mulatta prediction 9544 641440 - Ensembl:ENSMMUG00000023646 8 - BCL2/adenovirus E1B 19kDa interacting protein 3-like protein-coding - mml-miR-30c predicted by miR-30d (Homo sapiens), and BNIP3L predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 3168 mml-miR-195 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0006228 miRNA ATG14 autophagy down Macaca mulatta prediction 9544 697252 - Ensembl:ENSMMUG00000003761 7 - autophagy related 14 protein-coding - mml-miR-195 predicted by miR-195 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 3169 mml-miR-181c miR-181abcd/4262 MIMAT0002509 miRNA UVRAG autophagy down Macaca mulatta prediction 9544 696601 - Ensembl:ENSMMUG00000000187 14 - UV radiation resistance associated gene protein-coding - mml-miR-181c predicted by miR-181a (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22356768) 3170 mml-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006164 miRNA BECN1 autophagy down Macaca mulatta prediction 9544 711649 beclin-1 Ensembl:ENSMMUG00000029971 16 - beclin 1, autophagy related protein-coding - mml-miR-20b predicted by miR-17-5p (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (24755562),(25435430),(25485521) 3171 mml-miR-30c miR-30abcdef/30abe-5p/384-5p MIMAT0006170 miRNA ATG5 autophagy down Macaca mulatta prediction 9544 696874 - Ensembl:ENSMMUG00000019679 4 - autophagy related 5 protein-coding - mml-miR-30c predicted by miR-30a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22395361),(22617440),(22902544),(23274497),(24148619) 3172 mml-miR-374b miR-374ab MIMAT0006301 miRNA UVRAG autophagy down Macaca mulatta prediction 9544 696601 - Ensembl:ENSMMUG00000000187 14 - UV radiation resistance associated gene protein-coding - mml-miR-374b predicted by miR-374a (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22356768) 3173 mml-miR-302c miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0006261 miRNA SQSTM1 autophagy down Macaca mulatta prediction 9544 705481 - Ensembl:ENSMMUG00000021055 6 - sequestosome 1 protein-coding - mml-miR-302c predicted by miR-372 (Homo sapiens), and SQSTM1 predicted by SQSTM1 (Homo sapiens) according to Pubmed ID (24991827) 3174 mml-miR-17-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002700 miRNA BECN1 autophagy down Macaca mulatta prediction 9544 711649 beclin-1 Ensembl:ENSMMUG00000029971 16 - beclin 1, autophagy related protein-coding - mml-miR-17-5p predicted by miR-17-5p (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (24755562),(25435430),(25485521) 3175 ptr-miR-199a-5p miR-199ab-5p MIMAT0002530 miRNA DRAM1 autophagy down Pan troglodytes prediction 9598 740763 DRAM Ensembl:ENSPTRG00000005357 12 - DNA-damage regulated autophagy modulator 1 protein-coding - ptr-miR-199a-5p predicted by miR-199a-5p (Homo sapiens), and DRAM1 predicted by DRAM1 (Homo sapiens) according to Pubmed ID (23337876) 3176 ptr-miR-424 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0008143 miRNA ATG14 autophagy down Pan troglodytes prediction 9598 744098 - Ensembl:ENSPTRG00000006375 14 - autophagy related 14 protein-coding - ptr-miR-424 predicted by miR-195 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 3177 ptr-miR-374a miR-374ab MIMAT0008123 miRNA ATG10 autophagy down Pan troglodytes prediction 9598 461768 - Ensembl:ENSPTRG00000017050 5 - autophagy related 10 protein-coding - ptr-miR-374a predicted by miR-374a (Homo sapiens), and ATG10 predicted by ATG10 (Homo sapiens) according to Pubmed ID (22356768) 3178 ptr-miR-15b miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0002206 miRNA ATG7 autophagy down Pan troglodytes prediction 9598 470747 - Ensembl:ENSPTRG00000014625 3 - autophagy related 7 protein-coding - ptr-miR-15b predicted by miR-16 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23143396) 3179 ptr-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002769 miRNA BECN1 autophagy down Pan troglodytes prediction 9598 454700 beclin-1 Ensembl:ENSPTRG00000022819 17 - beclin 1, autophagy related protein-coding - ptr-miR-106b predicted by miR-17-5p (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (24755562),(25435430),(25485521) 3180 ptr-miR-100 miR-99ab/100 MIMAT0002421 miRNA IGF1R autophagy down Pan troglodytes prediction 9598 453676 - Ensembl:ENSPTRG00000007489 15 - insulin-like growth factor 1 receptor protein-coding - ptr-miR-100 predicted by miR-100 (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25026290) 3181 ptr-let-7c let-7/98/4458/4500 MIMAT0007938 miRNA ATG4B autophagy down Pan troglodytes prediction 9598 748674 - - 2B - autophagy related 4B, cysteine peptidase protein-coding - ptr-let-7c predicted by let-7b (Homo sapiens), and ATG4B predicted by ATG4B (Homo sapiens) according to Pubmed ID (22135297) 3182 ptr-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0008069 miRNA ATG16L1 autophagy down Pan troglodytes prediction 9598 460022 - Ensembl:ENSPTRG00000013051 2B - autophagy related 16-like 1 (S. cerevisiae) protein-coding - ptr-miR-20b predicted by miR-106b (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 3183 ptr-let-7c let-7/98/4458/4500 MIMAT0007938 miRNA OLR1 autophagy down Pan troglodytes prediction 9598 473362 - Ensembl:ENSPTRG00000004668 12 - oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding - ptr-let-7c predicted by let-7g (Mus musculus), and OLR1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 3184 ptr-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002769 miRNA ULK1 autophagy down Pan troglodytes prediction 9598 744289 - - 12 - unc-51-like kinase 1 (C. elegans) protein-coding - ptr-miR-106b predicted by miR-106b (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 3185 ptr-miR-221 miR-221/222/222ab/1928 MIMAT0008076 miRNA CDKN1B autophagy down Pan troglodytes prediction 9598 466947 - Ensembl:ENSPTRG00000004707 12 - cyclin-dependent kinase inhibitor 1B (p27, Kip1) protein-coding - ptr-miR-221 predicted by miR-221 (Homo sapiens), and CDKN1B predicted by CDKN1B (Homo sapiens) according to Pubmed ID (25394488) 3186 ptr-miR-375 miR-375 MIMAT0008125 miRNA RB1CC1 autophagy down Pan troglodytes prediction 9598 464173 - Ensembl:ENSPTRG00000020246 8 - RB1-inducible coiled-coil 1 protein-coding - ptr-miR-375 predicted by miR-375 (Homo sapiens), and RB1CC1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (22135297) 3187 ptr-let-7f let-7/98/4458/4500 MIMAT0007941 miRNA ATG4B autophagy down Pan troglodytes prediction 9598 748674 - - 2B - autophagy related 4B, cysteine peptidase protein-coding - ptr-let-7f predicted by let-7b (Homo sapiens), and ATG4B predicted by ATG4B (Homo sapiens) according to Pubmed ID (22135297) 3188 ptr-miR-302b miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008087 miRNA FYCO1 autophagy down Pan troglodytes prediction 9598 100614690 - Ensembl:ENSPTRG00000014842 3 - FYVE and coiled-coil domain containing 1 protein-coding - ptr-miR-302b predicted by miR-373 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3189 ptr-miR-424 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0008143 miRNA ATG7 autophagy down Pan troglodytes prediction 9598 470747 - Ensembl:ENSPTRG00000014625 3 - autophagy related 7 protein-coding - ptr-miR-424 predicted by miR-16 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23143396) 3190 ptr-miR-29b miR-29abcd MIMAT0002435 miRNA PSME4 autophagy down Pan troglodytes prediction 9598 459229 - Ensembl:ENSPTRG00000011920 2A - proteasome (prosome, macropain) activator subunit 4 protein-coding - ptr-miR-29b predicted by miR-29b (Homo sapiens), and PSME4 predicted by PSME4 (Homo sapiens) according to Pubmed ID (25234165) 3191 ptr-miR-301a miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0008084 miRNA FYCO1 autophagy down Pan troglodytes prediction 9598 100614690 - Ensembl:ENSPTRG00000014842 3 - FYVE and coiled-coil domain containing 1 protein-coding - ptr-miR-301a predicted by miR-130b (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3192 ptr-miR-130a miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0008025 miRNA RB1CC1 autophagy down Pan troglodytes prediction 9598 464173 - Ensembl:ENSPTRG00000020246 8 - RB1-inducible coiled-coil 1 protein-coding - ptr-miR-130a predicted by miR-133b (Homo sapiens), and RB1CC1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 3193 ptr-miR-211 miR-204/204b/211 MIMAT0008071 miRNA CAV1 autophagy down Pan troglodytes prediction 9598 463670 - Ensembl:ENSPTRG00000019613 7 - caveolin 1, caveolae protein, 22kDa protein-coding - ptr-miR-211 predicted by miR-204 (Homo sapiens), and CAV1 predicted by CAV1 (Homo sapiens) according to Pubmed ID (25517751) 3194 ptr-miR-15a miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0002654 miRNA ATG14 autophagy down Pan troglodytes prediction 9598 744098 - Ensembl:ENSPTRG00000006375 14 - autophagy related 14 protein-coding - ptr-miR-15a predicted by miR-195 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 3195 ptr-miR-18a miR-18ab/4735-3p MIMAT0002695 miRNA ATM autophagy down Pan troglodytes prediction 9598 451530 - - 11 - ataxia telangiectasia mutated protein-coding - ptr-miR-18a predicted by miR-18a (Homo sapiens), and ATM predicted by ATM (Homo sapiens) according to Pubmed ID (23229340) 3196 ptr-miR-199a-5p miR-199ab-5p MIMAT0002530 miRNA HSPA5 autophagy down Pan troglodytes prediction 9598 464733 - Ensembl:ENSPTRG00000000563 9 - heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) protein-coding - ptr-miR-199a-5p predicted by miR-199a-5p (Mus musculus), and HSPA5 predicted by Hspa5 (Mus musculus) according to Pubmed ID (23598416) 3197 ptr-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0008069 miRNA BECN1 autophagy down Pan troglodytes prediction 9598 454700 beclin-1 Ensembl:ENSPTRG00000022819 17 - beclin 1, autophagy related protein-coding - ptr-miR-20b predicted by miR-17-5p (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (24755562),(25435430),(25485521) 3198 ptr-miR-451 miR-451 MIMAT0008153 miRNA TSC1 autophagy down Pan troglodytes prediction 9598 464818 - Ensembl:ENSPTRG00000021504 9 - tuberous sclerosis 1 protein-coding - ptr-miR-451 predicted by miR-451 (Homo sapiens), and TSC1 predicted by TSC1 (Homo sapiens) according to Pubmed ID (25209900) 3199 ptr-miR-374b miR-374ab MIMAT0008124 miRNA ATG10 autophagy down Pan troglodytes prediction 9598 461768 - Ensembl:ENSPTRG00000017050 5 - autophagy related 10 protein-coding - ptr-miR-374b predicted by miR-374a (Homo sapiens), and ATG10 predicted by ATG10 (Homo sapiens) according to Pubmed ID (22356768) 3200 ptr-miR-155 miR-155 MIMAT0008048 miRNA RICTOR autophagy down Pan troglodytes prediction 9598 461907 - Ensembl:ENSPTRG00000016811 5 - RPTOR independent companion of MTOR, complex 2 protein-coding - ptr-miR-155 predicted by miR-155 (Homo sapiens), and RICTOR predicted by RICTOR (Homo sapiens) according to Pubmed ID (24262949) 3201 ptr-miR-21 miR-21/590-5p MIMAT0002321 miRNA BCL2 autophagy down Pan troglodytes prediction 9598 738409 - Ensembl:ENSPTRG00000010079 18 - B-cell CLL/lymphoma 2 protein-coding - ptr-miR-21 predicted by miR-21 (Homo sapiens), and BCL2 predicted by BCL2 (Homo sapiens) according to Pubmed ID (23834154) 3202 ptr-miR-215 miR-192/215 MIMAT0002730 miRNA UVRAG autophagy down Pan troglodytes prediction 9598 451430 - Ensembl:ENSPTRG00000004088 11 - UV radiation resistance associated gene protein-coding - ptr-miR-215 predicted by miR-215 (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (19074876),(22135297) 3203 ptr-let-7d let-7/98/4458/4500 MIMAT0007939 miRNA ATG4B autophagy down Pan troglodytes prediction 9598 748674 - - 2B - autophagy related 4B, cysteine peptidase protein-coding - ptr-let-7d predicted by let-7b (Homo sapiens), and ATG4B predicted by ATG4B (Homo sapiens) according to Pubmed ID (22135297) 3204 ptr-miR-520b miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008198 miRNA ULK1 autophagy down Pan troglodytes prediction 9598 744289 - - 12 - unc-51-like kinase 1 (C. elegans) protein-coding - ptr-miR-520b predicted by miR-291 (Mus musculus), and ULK1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 3205 ptr-miR-204 miR-204/204b/211 MIMAT0002535 miRNA TRPM3 autophagy down Pan troglodytes prediction 9598 464521 - Ensembl:ENSPTRG00000021014 9 - transient receptor potential cation channel, subfamily M, member 3 protein-coding - ptr-miR-204 predicted by miR-204 (Homo sapiens), and TRPM3 predicted by TRPM3 (Homo sapiens) according to Pubmed ID (25517751) 3206 ptr-miR-19a miR-19ab MIMAT0002696 miRNA ULK1 autophagy down Pan troglodytes prediction 9598 744289 - - 12 - unc-51-like kinase 1 (C. elegans) protein-coding - ptr-miR-19a predicted by miR-19b (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (25617127) 3207 ptr-miR-22 miR-22/22-3p MIMAT0002332 miRNA BTG1 autophagy down Pan troglodytes prediction 9598 452121 - Ensembl:ENSPTRG00000005291 12 - B-cell translocation gene 1, anti-proliferative protein-coding - ptr-miR-22 predicted by miR-22 (Homo sapiens), and BTG1 predicted by BTG1 (Homo sapiens) according to Pubmed ID (25449431) 3208 ptr-let-7d let-7/98/4458/4500 MIMAT0007939 miRNA IGF1R autophagy down Pan troglodytes prediction 9598 453676 - Ensembl:ENSPTRG00000007489 15 - insulin-like growth factor 1 receptor protein-coding - ptr-let-7d predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 3209 ptr-miR-155 miR-155 MIMAT0008048 miRNA GSK3B autophagy down Pan troglodytes prediction 9598 100616510 - Ensembl:ENSPTRG00000015264 3 - glycogen synthase kinase 3 beta protein-coding - ptr-miR-155 predicted by miR-155 (Homo sapiens), and GSK3B predicted by GSK3B (Homo sapiens) according to Pubmed ID (24343269) 3210 ptr-miR-181c miR-181abcd/4262 MIMAT0002510 miRNA ATG10 autophagy down Pan troglodytes prediction 9598 461768 - Ensembl:ENSPTRG00000017050 5 - autophagy related 10 protein-coding - ptr-miR-181c predicted by miR-181a (Homo sapiens), and ATG10 predicted by ATG10 (Homo sapiens) according to Pubmed ID (22356768) 3211 ptr-miR-130b miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0008026 miRNA RB1CC1 autophagy down Pan troglodytes prediction 9598 464173 - Ensembl:ENSPTRG00000020246 8 - RB1-inducible coiled-coil 1 protein-coding - ptr-miR-130b predicted by miR-133b (Homo sapiens), and RB1CC1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 3212 ptr-miR-155 miR-155 MIMAT0008048 miRNA RHEB autophagy down Pan troglodytes prediction 9598 463880 - - 7 - Ras homolog enriched in brain protein-coding - ptr-miR-155 predicted by miR-155 (Homo sapiens), and RHEB predicted by RHEB (Homo sapiens) according to Pubmed ID (24130493),(24262949) 3213 ptr-miR-17-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002693 miRNA FYCO1 autophagy down Pan troglodytes prediction 9598 100614690 - Ensembl:ENSPTRG00000014842 3 - FYVE and coiled-coil domain containing 1 protein-coding - ptr-miR-17-5p predicted by miR-93 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3214 ptr-miR-98 let-7/98/4458/4500 MIMAT0002405 miRNA ATG4B autophagy down Pan troglodytes prediction 9598 748674 - - 2B - autophagy related 4B, cysteine peptidase protein-coding - ptr-miR-98 predicted by let-7b (Homo sapiens), and ATG4B predicted by ATG4B (Homo sapiens) according to Pubmed ID (22135297) 3215 ptr-miR-1271 miR-96/507/1271 MIMAT0007992 miRNA ATG7 autophagy down Pan troglodytes prediction 9598 470747 - Ensembl:ENSPTRG00000014625 3 - autophagy related 7 protein-coding - ptr-miR-1271 predicted by miR-96 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (25333253) 3216 ptr-miR-17-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002693 miRNA BECN1 autophagy down Pan troglodytes prediction 9598 454700 beclin-1 Ensembl:ENSPTRG00000022819 17 - beclin 1, autophagy related protein-coding - ptr-miR-17-5p predicted by miR-17-5p (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (24755562),(25435430),(25485521) 3217 ptr-miR-335 miR-335/335-5p MIMAT0008104 miRNA ULK2 autophagy down Pan troglodytes prediction 9598 454507 - - 17 - unc-51-like kinase 2 (C. elegans) protein-coding - ptr-miR-335 predicted by miR-335 (Homo sapiens), and ULK2 predicted by ULK2 (Homo sapiens) according to Pubmed ID (18185580) 3218 ptr-miR-16 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0002655 miRNA ATG14 autophagy down Pan troglodytes prediction 9598 744098 - Ensembl:ENSPTRG00000006375 14 - autophagy related 14 protein-coding - ptr-miR-16 predicted by miR-195 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 3219 ptr-miR-320c miR-320abcd/4429 MIMAT0008095 miRNA ULK1 autophagy down Pan troglodytes prediction 9598 744289 - - 12 - unc-51-like kinase 1 (C. elegans) protein-coding - ptr-miR-320c predicted by miR-320a (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (23622248) 3220 ptr-miR-374a miR-374ab MIMAT0008123 miRNA TP63 autophagy down Pan troglodytes prediction 9598 460930 TP73L Ensembl:ENSPTRG00000015733 3 - tumor protein p63 protein-coding - ptr-miR-374a predicted by miR-374a (Homo sapiens), and TP63 predicted by TP63 (Homo sapiens) according to Pubmed ID (22356768) 3221 ptr-let-7i let-7/98/4458/4500 MIMAT0007943 miRNA OLR1 autophagy down Pan troglodytes prediction 9598 473362 - Ensembl:ENSPTRG00000004668 12 - oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding - ptr-let-7i predicted by let-7g (Mus musculus), and OLR1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 3222 ptr-miR-302b miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008087 miRNA ULK1 autophagy down Pan troglodytes prediction 9598 744289 - - 12 - unc-51-like kinase 1 (C. elegans) protein-coding - ptr-miR-302b predicted by miR-291 (Mus musculus), and ULK1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 3223 ptr-miR-106a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002800 miRNA BECN1 autophagy down Pan troglodytes prediction 9598 454700 beclin-1 Ensembl:ENSPTRG00000022819 17 - beclin 1, autophagy related protein-coding - ptr-miR-106a predicted by miR-17-5p (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (24755562),(25435430),(25485521) 3224 ptr-miR-199a-5p miR-199ab-5p MIMAT0002530 miRNA BECN1 autophagy down Pan troglodytes prediction 9598 454700 beclin-1 Ensembl:ENSPTRG00000022819 17 - beclin 1, autophagy related protein-coding - ptr-miR-199a-5p predicted by miR-199a-5p (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (23337876) 3225 ptr-miR-320d miR-320abcd/4429 MIMAT0008096 miRNA ULK1 autophagy down Pan troglodytes prediction 9598 744289 - - 12 - unc-51-like kinase 1 (C. elegans) protein-coding - ptr-miR-320d predicted by miR-320a (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (23622248) 3226 ptr-miR-15a miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0002654 miRNA BCL2L2 autophagy down Pan troglodytes prediction 9598 100611631 - Ensembl:ENSPTRG00000006167 14 - BCL2-like 2 protein-coding - ptr-miR-15a predicted by miR-15b (Mus musculus), and BCL2L2 predicted by Bcl2l2 (Mus musculus) according to Pubmed ID (21770019) 3227 ptr-miR-30a-5p miR-30abcdef/30abe-5p/384-5p MIMAT0002371 miRNA ATG2B autophagy down Pan troglodytes prediction 9598 453143 - Ensembl:ENSPTRG00000006700 14 - autophagy related 2B protein-coding - ptr-miR-30a-5p predicted by mir-30d (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (23274497) 3228 ptr-miR-302d miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008089 miRNA FYCO1 autophagy down Pan troglodytes prediction 9598 100614690 - Ensembl:ENSPTRG00000014842 3 - FYVE and coiled-coil domain containing 1 protein-coding - ptr-miR-302d predicted by miR-373 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3229 ptr-miR-454 miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0008156 miRNA FYCO1 autophagy down Pan troglodytes prediction 9598 100614690 - Ensembl:ENSPTRG00000014842 3 - FYVE and coiled-coil domain containing 1 protein-coding - ptr-miR-454 predicted by miR-130b (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3230 ptr-miR-30c miR-30abcdef/30abe-5p/384-5p MIMAT0002614 miRNA BNIP3L autophagy down Pan troglodytes prediction 9598 464069 - Ensembl:ENSPTRG00000020097 8 - BCL2/adenovirus E1B 19kDa interacting protein 3-like protein-coding - ptr-miR-30c predicted by miR-30d (Homo sapiens), and BNIP3L predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 3231 ptr-miR-367 miR-25/32/92abc/363/363-3p/367 MIMAT0008118 miRNA ULK1 autophagy down Pan troglodytes prediction 9598 744289 - - 12 - unc-51-like kinase 1 (C. elegans) protein-coding - ptr-miR-367 predicted by miR-25 (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (25026296) 3232 ptr-miR-17-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002693 miRNA ATG16L1 autophagy down Pan troglodytes prediction 9598 460022 - Ensembl:ENSPTRG00000013051 2B - autophagy related 16-like 1 (S. cerevisiae) protein-coding - ptr-miR-17-5p predicted by miR-106b (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 3233 ptr-miR-130b miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0008026 miRNA ATG2B autophagy down Pan troglodytes prediction 9598 453143 - Ensembl:ENSPTRG00000006700 14 - autophagy related 2B protein-coding - ptr-miR-130b predicted by miR-130a (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (22902544) 3234 ptr-miR-21 miR-21/590-5p MIMAT0002321 miRNA PTEN autophagy down Pan troglodytes prediction 9598 466142 - - 10 - phosphatase and tensin homolog protein-coding - ptr-miR-21 predicted by miR-21 (Rattus norvegicus), and PTEN predicted by Pten (Rattus norvegicus) according to Pubmed ID (25689721) 3235 ptr-miR-106a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002800 miRNA ULK1 autophagy down Pan troglodytes prediction 9598 744289 - - 12 - unc-51-like kinase 1 (C. elegans) protein-coding - ptr-miR-106a predicted by miR-106b (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 3236 ptr-miR-92 miR-25/32/92abc/363/363-3p/367 MIMAT0002699 miRNA ULK1 autophagy down Pan troglodytes prediction 9598 744289 - - 12 - unc-51-like kinase 1 (C. elegans) protein-coding - ptr-miR-92 predicted by miR-25 (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (25026296) 3237 ptr-miR-302a miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008086 miRNA FYCO1 autophagy down Pan troglodytes prediction 9598 100614690 - Ensembl:ENSPTRG00000014842 3 - FYVE and coiled-coil domain containing 1 protein-coding - ptr-miR-302a predicted by miR-373 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3238 ptr-miR-454 miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0008156 miRNA RB1CC1 autophagy down Pan troglodytes prediction 9598 464173 - Ensembl:ENSPTRG00000020246 8 - RB1-inducible coiled-coil 1 protein-coding - ptr-miR-454 predicted by miR-133b (Homo sapiens), and RB1CC1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 3239 ptr-miR-19b miR-19ab MIMAT0002698 miRNA ULK1 autophagy down Pan troglodytes prediction 9598 744289 - - 12 - unc-51-like kinase 1 (C. elegans) protein-coding - ptr-miR-19b predicted by miR-19b (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (25617127) 3240 ptr-miR-216b miR-216b/216b-5p MIMAT0008072 miRNA BECN1 autophagy down Pan troglodytes prediction 9598 454700 beclin-1 Ensembl:ENSPTRG00000022819 17 - beclin 1, autophagy related protein-coding - ptr-miR-216b predicted by miR-216b (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (24681041) 3241 ptr-miR-144 miR-144 MIMAT0002262 miRNA C12H12orf5 autophagy down Pan troglodytes prediction 9598 466924 - Ensembl:ENSPTRG00000004550 12 - chromosome 12 open reading frame, human C12orf5 protein-coding - ptr-miR-144 predicted by miR-144 (Homo sapiens), and C12H12orf5 predicted by C12orf5 (Homo sapiens) according to Pubmed ID (25660220) 3242 ptr-miR-520b miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008198 miRNA FYCO1 autophagy down Pan troglodytes prediction 9598 100614690 - Ensembl:ENSPTRG00000014842 3 - FYVE and coiled-coil domain containing 1 protein-coding - ptr-miR-520b predicted by miR-373 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3243 ptr-miR-424 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0008143 miRNA BCL2L2 autophagy down Pan troglodytes prediction 9598 100611631 - Ensembl:ENSPTRG00000006167 14 - BCL2-like 2 protein-coding - ptr-miR-424 predicted by miR-15b (Mus musculus), and BCL2L2 predicted by Bcl2l2 (Mus musculus) according to Pubmed ID (21770019) 3244 ptr-miR-32 miR-25/32/92abc/363/363-3p/367 MIMAT0002386 miRNA ULK1 autophagy down Pan troglodytes prediction 9598 744289 - - 12 - unc-51-like kinase 1 (C. elegans) protein-coding - ptr-miR-32 predicted by miR-25 (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (25026296) 3245 ptr-miR-302c miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008088 miRNA ULK1 autophagy down Pan troglodytes prediction 9598 744289 - - 12 - unc-51-like kinase 1 (C. elegans) protein-coding - ptr-miR-302c predicted by miR-291 (Mus musculus), and ULK1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 3246 ptr-let-7e let-7/98/4458/4500 MIMAT0007940 miRNA OLR1 autophagy down Pan troglodytes prediction 9598 473362 - Ensembl:ENSPTRG00000004668 12 - oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding - ptr-let-7e predicted by let-7g (Mus musculus), and OLR1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 3247 ptr-miR-181a miR-181abcd/4262 MIMAT0002505 miRNA ATG5 autophagy down Pan troglodytes prediction 9598 462905 APG5L Ensembl:ENSPTRG00000018458 6 - autophagy related 5 protein-coding - ptr-miR-181a predicted by miR-181a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22356768),(22902544),(23322078) 3248 ptr-miR-30a-5p miR-30abcdef/30abe-5p/384-5p MIMAT0002371 miRNA BNIP3L autophagy down Pan troglodytes prediction 9598 464069 - Ensembl:ENSPTRG00000020097 8 - BCL2/adenovirus E1B 19kDa interacting protein 3-like protein-coding - ptr-miR-30a-5p predicted by miR-30d (Homo sapiens), and BNIP3L predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 3249 ptr-miR-520b miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008198 miRNA SQSTM1 autophagy down Pan troglodytes prediction 9598 462333 - Ensembl:ENSPTRG00000017626 5 - sequestosome 1 protein-coding - ptr-miR-520b predicted by miR-372 (Homo sapiens), and SQSTM1 predicted by SQSTM1 (Homo sapiens) according to Pubmed ID (24991827) 3250 ptr-miR-367 miR-25/32/92abc/363/363-3p/367 MIMAT0008118 miRNA UVRAG autophagy down Pan troglodytes prediction 9598 451430 - Ensembl:ENSPTRG00000004088 11 - UV radiation resistance associated gene protein-coding - ptr-miR-367 predicted by miR-32 (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22135297) 3251 ptr-miR-96 miR-96/507/1271 MIMAT0002786 miRNA ATG7 autophagy down Pan troglodytes prediction 9598 470747 - Ensembl:ENSPTRG00000014625 3 - autophagy related 7 protein-coding - ptr-miR-96 predicted by miR-96 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (25333253) 3252 ptr-miR-181d miR-181abcd/4262 MIMAT0008049 miRNA ATG5 autophagy down Pan troglodytes prediction 9598 462905 APG5L Ensembl:ENSPTRG00000018458 6 - autophagy related 5 protein-coding - ptr-miR-181d predicted by miR-181a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22356768),(22902544),(23322078) 3253 ptr-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0008069 miRNA ATG5 autophagy down Pan troglodytes prediction 9598 462905 APG5L Ensembl:ENSPTRG00000018458 6 - autophagy related 5 protein-coding - ptr-miR-20b predicted by miR-20a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (25485521) 3254 ptr-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0008069 miRNA SQSTM1 autophagy down Pan troglodytes prediction 9598 462333 - Ensembl:ENSPTRG00000017626 5 - sequestosome 1 protein-coding - ptr-miR-20b predicted by miR-106b (Homo sapiens),miR-106 (Mus musculus), and SQSTM1 predicted by Sqstm1 (Mus musculus),SQSTM1 (Homo sapiens) according to Pubmed ID (21628417),(22441107),(25485521),(25617127) 3255 ptr-miR-302a miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008086 miRNA SQSTM1 autophagy down Pan troglodytes prediction 9598 462333 - Ensembl:ENSPTRG00000017626 5 - sequestosome 1 protein-coding - ptr-miR-302a predicted by miR-372 (Homo sapiens), and SQSTM1 predicted by SQSTM1 (Homo sapiens) according to Pubmed ID (24991827) 3256 ptr-let-7f let-7/98/4458/4500 MIMAT0007941 miRNA OLR1 autophagy down Pan troglodytes prediction 9598 473362 - Ensembl:ENSPTRG00000004668 12 - oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding - ptr-let-7f predicted by let-7g (Mus musculus), and OLR1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 3257 ptr-miR-30d miR-30abcdef/30abe-5p/384-5p MIMAT0002617 miRNA ATG2B autophagy down Pan troglodytes prediction 9598 453143 - Ensembl:ENSPTRG00000006700 14 - autophagy related 2B protein-coding - ptr-miR-30d predicted by mir-30d (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (23274497) 3258 ptr-miR-101 miR-101/101ab MIMAT0002430 miRNA STMN1 autophagy down Pan troglodytes prediction 9598 456650 - - 1 - stathmin 1 protein-coding - ptr-miR-101 predicted by miR-101 (Homo sapiens), and STMN1 predicted by STMN1 (Homo sapiens) according to Pubmed ID (21915098),(23483142),(25607713) 3259 ptr-let-7f let-7/98/4458/4500 MIMAT0007941 miRNA IGF1R autophagy down Pan troglodytes prediction 9598 453676 - Ensembl:ENSPTRG00000007489 15 - insulin-like growth factor 1 receptor protein-coding - ptr-let-7f predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 3260 ptr-miR-186 miR-186 MIMAT0002304 miRNA ULK1 autophagy down Pan troglodytes prediction 9598 744289 - - 12 - unc-51-like kinase 1 (C. elegans) protein-coding - ptr-miR-186 predicted by miR-186 (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (23622248) 3261 ptr-miR-520b miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008198 miRNA ATG7 autophagy down Pan troglodytes prediction 9598 470747 - Ensembl:ENSPTRG00000014625 3 - autophagy related 7 protein-coding - ptr-miR-520b predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 3262 ptr-miR-30c miR-30abcdef/30abe-5p/384-5p MIMAT0002614 miRNA BECN1 autophagy down Pan troglodytes prediction 9598 454700 beclin-1 Ensembl:ENSPTRG00000022819 17 - beclin 1, autophagy related protein-coding - ptr-miR-30c predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and BECN1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 3263 ptr-miR-302c miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008088 miRNA FYCO1 autophagy down Pan troglodytes prediction 9598 100614690 - Ensembl:ENSPTRG00000014842 3 - FYVE and coiled-coil domain containing 1 protein-coding - ptr-miR-302c predicted by miR-373 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3264 ptr-miR-302a miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008086 miRNA ULK1 autophagy down Pan troglodytes prediction 9598 744289 - - 12 - unc-51-like kinase 1 (C. elegans) protein-coding - ptr-miR-302a predicted by miR-291 (Mus musculus), and ULK1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 3265 ptr-miR-372 miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008122 miRNA ATG7 autophagy down Pan troglodytes prediction 9598 470747 - Ensembl:ENSPTRG00000014625 3 - autophagy related 7 protein-coding - ptr-miR-372 predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 3266 ptr-miR-34a miR-34ac/34bc-5p/449abc/449c-5p MIMAT0002498 miRNA ATG4B autophagy down Pan troglodytes prediction 9598 748674 - - 2B - autophagy related 4B, cysteine peptidase protein-coding - ptr-miR-34a predicted by miR-34a (Homo sapiens), and ATG4B predicted by ATG4B (Homo sapiens) according to Pubmed ID (24755409) 3267 ptr-miR-106a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002800 miRNA ATG5 autophagy down Pan troglodytes prediction 9598 462905 APG5L Ensembl:ENSPTRG00000018458 6 - autophagy related 5 protein-coding - ptr-miR-106a predicted by miR-20a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (25485521) 3268 ptr-miR-375 miR-375 MIMAT0008125 miRNA SP1 autophagy down Pan troglodytes prediction 9598 451939 - Ensembl:ENSPTRG00000005014 12 - Sp1 transcription factor protein-coding - ptr-miR-375 predicted by miR-375 (Homo sapiens), and SP1 predicted by SP1 (Homo sapiens) according to Pubmed ID (22606351) 3269 ptr-miR-520d miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008200 miRNA FYCO1 autophagy down Pan troglodytes prediction 9598 100614690 - Ensembl:ENSPTRG00000014842 3 - FYVE and coiled-coil domain containing 1 protein-coding - ptr-miR-520d predicted by miR-373 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3270 ptr-miR-301a miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0008084 miRNA RB1CC1 autophagy down Pan troglodytes prediction 9598 464173 - Ensembl:ENSPTRG00000020246 8 - RB1-inducible coiled-coil 1 protein-coding - ptr-miR-301a predicted by miR-133b (Homo sapiens), and RB1CC1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 3271 ptr-miR-372 miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008122 miRNA ULK1 autophagy down Pan troglodytes prediction 9598 744289 - - 12 - unc-51-like kinase 1 (C. elegans) protein-coding - ptr-miR-372 predicted by miR-291 (Mus musculus), and ULK1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 3272 ptr-let-7b let-7/98/4458/4500 MIMAT0007937 miRNA IGF1R autophagy down Pan troglodytes prediction 9598 453676 - Ensembl:ENSPTRG00000007489 15 - insulin-like growth factor 1 receptor protein-coding - ptr-let-7b predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 3273 ptr-miR-30b miR-30abcdef/30abe-5p/384-5p MIMAT0002214 miRNA ATG5 autophagy down Pan troglodytes prediction 9598 462905 APG5L Ensembl:ENSPTRG00000018458 6 - autophagy related 5 protein-coding - ptr-miR-30b predicted by miR-30a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22395361),(22617440),(22902544),(23274497),(24148619) 3274 ptr-miR-519d miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0008195 miRNA ATG5 autophagy down Pan troglodytes prediction 9598 462905 APG5L Ensembl:ENSPTRG00000018458 6 - autophagy related 5 protein-coding - ptr-miR-519d predicted by miR-20a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (25485521) 3275 ptr-miR-30e miR-30abcdef/30abe-5p/384-5p MIMAT0008092 miRNA BNIP3L autophagy down Pan troglodytes prediction 9598 464069 - Ensembl:ENSPTRG00000020097 8 - BCL2/adenovirus E1B 19kDa interacting protein 3-like protein-coding - ptr-miR-30e predicted by miR-30d (Homo sapiens), and BNIP3L predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 3276 ptr-miR-519d miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0008195 miRNA ATG16L1 autophagy down Pan troglodytes prediction 9598 460022 - Ensembl:ENSPTRG00000013051 2B - autophagy related 16-like 1 (S. cerevisiae) protein-coding - ptr-miR-519d predicted by miR-106b (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 3277 ptr-miR-181c miR-181abcd/4262 MIMAT0002510 miRNA UVRAG autophagy down Pan troglodytes prediction 9598 451430 - Ensembl:ENSPTRG00000004088 11 - UV radiation resistance associated gene protein-coding - ptr-miR-181c predicted by miR-181a (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22356768) 3278 ptr-miR-98 let-7/98/4458/4500 MIMAT0002405 miRNA IGF1R autophagy down Pan troglodytes prediction 9598 453676 - Ensembl:ENSPTRG00000007489 15 - insulin-like growth factor 1 receptor protein-coding - ptr-miR-98 predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 3279 ptr-miR-374b miR-374ab MIMAT0008124 miRNA TP63 autophagy down Pan troglodytes prediction 9598 460930 TP73L Ensembl:ENSPTRG00000015733 3 - tumor protein p63 protein-coding - ptr-miR-374b predicted by miR-374a (Homo sapiens), and TP63 predicted by TP63 (Homo sapiens) according to Pubmed ID (22356768) 3280 ptr-miR-130b miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0008026 miRNA FYCO1 autophagy down Pan troglodytes prediction 9598 100614690 - Ensembl:ENSPTRG00000014842 3 - FYVE and coiled-coil domain containing 1 protein-coding - ptr-miR-130b predicted by miR-130b (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3281 ptr-miR-519d miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0008195 miRNA BECN1 autophagy down Pan troglodytes prediction 9598 454700 beclin-1 Ensembl:ENSPTRG00000022819 17 - beclin 1, autophagy related protein-coding - ptr-miR-519d predicted by miR-17-5p (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (24755562),(25435430),(25485521) 3282 ptr-miR-98 let-7/98/4458/4500 MIMAT0002405 miRNA OLR1 autophagy down Pan troglodytes prediction 9598 473362 - Ensembl:ENSPTRG00000004668 12 - oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding - ptr-miR-98 predicted by let-7g (Mus musculus), and OLR1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 3283 ptr-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002769 miRNA ATG7 autophagy down Pan troglodytes prediction 9598 470747 - Ensembl:ENSPTRG00000014625 3 - autophagy related 7 protein-coding - ptr-miR-106b predicted by miR-17 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 3284 ptr-miR-29c miR-29abcd MIMAT0008082 miRNA ATG14 autophagy down Pan troglodytes prediction 9598 744098 - Ensembl:ENSPTRG00000006375 14 - autophagy related 14 protein-coding - ptr-miR-29c predicted by miR-29b (Bos taurus), and ATG14 predicted by ATG14 (Bos taurus) according to Pubmed ID (25234643) 3285 ptr-miR-372 miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008122 miRNA SQSTM1 autophagy down Pan troglodytes prediction 9598 462333 - Ensembl:ENSPTRG00000017626 5 - sequestosome 1 protein-coding - ptr-miR-372 predicted by miR-372 (Homo sapiens), and SQSTM1 predicted by SQSTM1 (Homo sapiens) according to Pubmed ID (24991827) 3286 ptr-miR-144 miR-144 MIMAT0002262 miRNA GSK3B autophagy down Pan troglodytes prediction 9598 100616510 - Ensembl:ENSPTRG00000015264 3 - glycogen synthase kinase 3 beta protein-coding - ptr-miR-144 predicted by miR-144 (Homo sapiens), and GSK3B predicted by GSK3B (Homo sapiens) according to Pubmed ID (25060662) 3287 ptr-miR-106a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002800 miRNA SQSTM1 autophagy down Pan troglodytes prediction 9598 462333 - Ensembl:ENSPTRG00000017626 5 - sequestosome 1 protein-coding - ptr-miR-106a predicted by miR-106b (Homo sapiens),miR-106 (Mus musculus), and SQSTM1 predicted by Sqstm1 (Mus musculus),SQSTM1 (Homo sapiens) according to Pubmed ID (21628417),(22441107),(25485521),(25617127) 3288 ptr-miR-18b miR-18ab/4735-3p MIMAT0008054 miRNA ATM autophagy down Pan troglodytes prediction 9598 451530 - - 11 - ataxia telangiectasia mutated protein-coding - ptr-miR-18b predicted by miR-18a (Homo sapiens), and ATM predicted by ATM (Homo sapiens) according to Pubmed ID (23229340) 3289 ptr-miR-106a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002800 miRNA FYCO1 autophagy down Pan troglodytes prediction 9598 100614690 - Ensembl:ENSPTRG00000014842 3 - FYVE and coiled-coil domain containing 1 protein-coding - ptr-miR-106a predicted by miR-93 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3290 ptr-miR-335 miR-335/335-5p MIMAT0008104 miRNA ULK1 autophagy down Pan troglodytes prediction 9598 744289 - - 12 - unc-51-like kinase 1 (C. elegans) protein-coding - ptr-miR-335 predicted by miR-335 (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22135297) 3291 ptr-miR-181d miR-181abcd/4262 MIMAT0008049 miRNA ATG10 autophagy down Pan troglodytes prediction 9598 461768 - Ensembl:ENSPTRG00000017050 5 - autophagy related 10 protein-coding - ptr-miR-181d predicted by miR-181a (Homo sapiens), and ATG10 predicted by ATG10 (Homo sapiens) according to Pubmed ID (22356768) 3292 ptr-miR-101 miR-101/101ab MIMAT0002430 miRNA ATG4D autophagy down Pan troglodytes prediction 9598 455708 - Ensembl:ENSPTRG00000010475 19 - autophagy related 4D, cysteine peptidase protein-coding - ptr-miR-101 predicted by miR-101 (Homo sapiens), and ATG4D predicted by (Homo sapiens),ATG4D (Homo sapiens) according to Pubmed ID (21915098),(22085996),(22902544),(23483142) 3293 ptr-miR-192 miR-192/215 MIMAT0008057 miRNA UVRAG autophagy down Pan troglodytes prediction 9598 451430 - Ensembl:ENSPTRG00000004088 11 - UV radiation resistance associated gene protein-coding - ptr-miR-192 predicted by miR-215 (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (19074876),(22135297) 3294 ptr-let-7i let-7/98/4458/4500 MIMAT0007943 miRNA IGF1R autophagy down Pan troglodytes prediction 9598 453676 - Ensembl:ENSPTRG00000007489 15 - insulin-like growth factor 1 receptor protein-coding - ptr-let-7i predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 3295 ptr-miR-99a miR-99ab/100 MIMAT0002411 miRNA IGF1R autophagy down Pan troglodytes prediction 9598 453676 - Ensembl:ENSPTRG00000007489 15 - insulin-like growth factor 1 receptor protein-coding - ptr-miR-99a predicted by miR-100 (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25026290) 3296 ptr-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0008069 miRNA ULK1 autophagy down Pan troglodytes prediction 9598 744289 - - 12 - unc-51-like kinase 1 (C. elegans) protein-coding - ptr-miR-20b predicted by miR-106b (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 3297 ptr-miR-520a miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008197 miRNA FYCO1 autophagy down Pan troglodytes prediction 9598 100614690 - Ensembl:ENSPTRG00000014842 3 - FYVE and coiled-coil domain containing 1 protein-coding - ptr-miR-520a predicted by miR-373 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3298 ptr-miR-302a miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008086 miRNA ATG7 autophagy down Pan troglodytes prediction 9598 470747 - Ensembl:ENSPTRG00000014625 3 - autophagy related 7 protein-coding - ptr-miR-302a predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 3299 ptr-miR-181a miR-181abcd/4262 MIMAT0002505 miRNA UVRAG autophagy down Pan troglodytes prediction 9598 451430 - Ensembl:ENSPTRG00000004088 11 - UV radiation resistance associated gene protein-coding - ptr-miR-181a predicted by miR-181a (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22356768) 3300 ptr-let-7d let-7/98/4458/4500 MIMAT0007939 miRNA OLR1 autophagy down Pan troglodytes prediction 9598 473362 - Ensembl:ENSPTRG00000004668 12 - oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding - ptr-let-7d predicted by let-7g (Mus musculus), and OLR1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 3301 ptr-miR-30e miR-30abcdef/30abe-5p/384-5p MIMAT0008092 miRNA ATG5 autophagy down Pan troglodytes prediction 9598 462905 APG5L Ensembl:ENSPTRG00000018458 6 - autophagy related 5 protein-coding - ptr-miR-30e predicted by miR-30a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22395361),(22617440),(22902544),(23274497),(24148619) 3302 ptr-miR-34a miR-34ac/34bc-5p/449abc/449c-5p MIMAT0002498 miRNA ATG9A autophagy down Pan troglodytes prediction 9598 742932 - Ensembl:ENSPTRG00000012943 2B - autophagy related 9A protein-coding - ptr-miR-34a predicted by miR-34a (Homo sapiens),miR-34a (Rattus norvegicus), and ATG9A predicted by Atg9a (Rattus norvegicus),ATG9A (Homo sapiens) according to Pubmed ID (22902544),(24728149),(24973144) 3303 ptr-miR-205 miR-205/205ab MIMAT0002544 miRNA RAB27A autophagy down Pan troglodytes prediction 9598 453455 - Ensembl:ENSPTRG00000007095 15 - RAB27A, member RAS oncogene family protein-coding - ptr-miR-205 predicted by miR-205 (Homo sapiens), and RAB27A predicted by RAB27A (Homo sapiens) according to Pubmed ID (24370341) 3304 ptr-miR-30d miR-30abcdef/30abe-5p/384-5p MIMAT0002617 miRNA ATG5 autophagy down Pan troglodytes prediction 9598 462905 APG5L Ensembl:ENSPTRG00000018458 6 - autophagy related 5 protein-coding - ptr-miR-30d predicted by miR-30a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22395361),(22617440),(22902544),(23274497),(24148619) 3305 ptr-miR-29b miR-29abcd MIMAT0002435 miRNA ATG9A autophagy down Pan troglodytes prediction 9598 742932 - Ensembl:ENSPTRG00000012943 2B - autophagy related 9A protein-coding - ptr-miR-29b predicted by miR-29b (Bos taurus), and ATG9A predicted by ATG9A (Bos taurus) according to Pubmed ID (25234643) 3306 ptr-miR-302b miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008087 miRNA SQSTM1 autophagy down Pan troglodytes prediction 9598 462333 - Ensembl:ENSPTRG00000017626 5 - sequestosome 1 protein-coding - ptr-miR-302b predicted by miR-372 (Homo sapiens), and SQSTM1 predicted by SQSTM1 (Homo sapiens) according to Pubmed ID (24991827) 3307 ptr-miR-17-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002693 miRNA ATG5 autophagy down Pan troglodytes prediction 9598 462905 APG5L Ensembl:ENSPTRG00000018458 6 - autophagy related 5 protein-coding - ptr-miR-17-5p predicted by miR-20a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (25485521) 3308 ptr-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002769 miRNA ATG5 autophagy down Pan troglodytes prediction 9598 462905 APG5L Ensembl:ENSPTRG00000018458 6 - autophagy related 5 protein-coding - ptr-miR-106b predicted by miR-20a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (25485521) 3309 ptr-miR-93 miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0002770 miRNA ULK1 autophagy down Pan troglodytes prediction 9598 744289 - - 12 - unc-51-like kinase 1 (C. elegans) protein-coding - ptr-miR-93 predicted by miR-291 (Mus musculus), and ULK1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 3310 ptr-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002697 miRNA ATG5 autophagy down Pan troglodytes prediction 9598 462905 APG5L Ensembl:ENSPTRG00000018458 6 - autophagy related 5 protein-coding - ptr-miR-20a predicted by miR-20a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (25485521) 3311 ptr-miR-15b miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0002206 miRNA BCL2L2 autophagy down Pan troglodytes prediction 9598 100611631 - Ensembl:ENSPTRG00000006167 14 - BCL2-like 2 protein-coding - ptr-miR-15b predicted by miR-15b (Mus musculus), and BCL2L2 predicted by Bcl2l2 (Mus musculus) according to Pubmed ID (21770019) 3312 ptr-miR-335 miR-335/335-5p MIMAT0008104 miRNA ATG16L2 autophagy down Pan troglodytes prediction 9598 748375 - Ensembl:ENSPTRG00000004039 11 - autophagy related 16-like 2 (S. cerevisiae) protein-coding - ptr-miR-335 predicted by miR-335 (Homo sapiens), and ATG16L2 predicted by ATG16L2 (Homo sapiens) according to Pubmed ID (18185580) 3313 ptr-let-7g let-7/98/4458/4500 MIMAT0007942 miRNA ATG4B autophagy down Pan troglodytes prediction 9598 748674 - - 2B - autophagy related 4B, cysteine peptidase protein-coding - ptr-let-7g predicted by let-7b (Homo sapiens), and ATG4B predicted by ATG4B (Homo sapiens) according to Pubmed ID (22135297) 3314 ptr-miR-520a miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008197 miRNA ATG7 autophagy down Pan troglodytes prediction 9598 470747 - Ensembl:ENSPTRG00000014625 3 - autophagy related 7 protein-coding - ptr-miR-520a predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 3315 ptr-let-7c let-7/98/4458/4500 MIMAT0007938 miRNA IGF1R autophagy down Pan troglodytes prediction 9598 453676 - Ensembl:ENSPTRG00000007489 15 - insulin-like growth factor 1 receptor protein-coding - ptr-let-7c predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 3316 ptr-miR-16 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0002655 miRNA ATG7 autophagy down Pan troglodytes prediction 9598 470747 - Ensembl:ENSPTRG00000014625 3 - autophagy related 7 protein-coding - ptr-miR-16 predicted by miR-16 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23143396) 3317 ptr-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002697 miRNA BECN1 autophagy down Pan troglodytes prediction 9598 454700 beclin-1 Ensembl:ENSPTRG00000022819 17 - beclin 1, autophagy related protein-coding - ptr-miR-20a predicted by miR-17-5p (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (24755562),(25435430),(25485521) 3318 ptr-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002697 miRNA SQSTM1 autophagy down Pan troglodytes prediction 9598 462333 - Ensembl:ENSPTRG00000017626 5 - sequestosome 1 protein-coding - ptr-miR-20a predicted by miR-106b (Homo sapiens),miR-106 (Mus musculus), and SQSTM1 predicted by Sqstm1 (Mus musculus),SQSTM1 (Homo sapiens) according to Pubmed ID (21628417),(22441107),(25485521),(25617127) 3319 ptr-miR-99b miR-99ab/100 MIMAT0008351 miRNA IGF1R autophagy down Pan troglodytes prediction 9598 453676 - Ensembl:ENSPTRG00000007489 15 - insulin-like growth factor 1 receptor protein-coding - ptr-miR-99b predicted by miR-100 (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25026290) 3320 ptr-miR-182 miR-182 MIMAT0008050 miRNA BCL2 autophagy down Pan troglodytes prediction 9598 738409 - Ensembl:ENSPTRG00000010079 18 - B-cell CLL/lymphoma 2 protein-coding - ptr-miR-182 predicted by miR-182 (Homo sapiens), and BCL2 predicted by BCL2 (Homo sapiens) according to Pubmed ID (23936432) 3321 ptr-miR-519d miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0008195 miRNA SQSTM1 autophagy down Pan troglodytes prediction 9598 462333 - Ensembl:ENSPTRG00000017626 5 - sequestosome 1 protein-coding - ptr-miR-519d predicted by miR-106b (Homo sapiens),miR-106 (Mus musculus), and SQSTM1 predicted by Sqstm1 (Mus musculus),SQSTM1 (Homo sapiens) according to Pubmed ID (21628417),(22441107),(25485521),(25617127) 3322 ptr-miR-17-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002693 miRNA SQSTM1 autophagy down Pan troglodytes prediction 9598 462333 - Ensembl:ENSPTRG00000017626 5 - sequestosome 1 protein-coding - ptr-miR-17-5p predicted by miR-106b (Homo sapiens),miR-106 (Mus musculus), and SQSTM1 predicted by Sqstm1 (Mus musculus),SQSTM1 (Homo sapiens) according to Pubmed ID (21628417),(22441107),(25485521),(25617127) 3323 ptr-let-7g let-7/98/4458/4500 MIMAT0007942 miRNA IGF1R autophagy down Pan troglodytes prediction 9598 453676 - Ensembl:ENSPTRG00000007489 15 - insulin-like growth factor 1 receptor protein-coding - ptr-let-7g predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 3324 ptr-miR-155 miR-155 MIMAT0008048 miRNA ATG3 autophagy down Pan troglodytes prediction 9598 470880 - Ensembl:ENSPTRG00000015220 3 - autophagy related 3 protein-coding - ptr-miR-155 predicted by miR-155 (Homo sapiens), and ATG3 predicted by ATG3 (Homo sapiens) according to Pubmed ID (22135297) 3325 ptr-miR-520d miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008200 miRNA SQSTM1 autophagy down Pan troglodytes prediction 9598 462333 - Ensembl:ENSPTRG00000017626 5 - sequestosome 1 protein-coding - ptr-miR-520d predicted by miR-372 (Homo sapiens), and SQSTM1 predicted by SQSTM1 (Homo sapiens) according to Pubmed ID (24991827) 3326 ptr-miR-106a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002800 miRNA ATG7 autophagy down Pan troglodytes prediction 9598 470747 - Ensembl:ENSPTRG00000014625 3 - autophagy related 7 protein-coding - ptr-miR-106a predicted by miR-17 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 3327 ptr-miR-25 miR-25/32/92abc/363/363-3p/367 MIMAT0002771 miRNA ULK1 autophagy down Pan troglodytes prediction 9598 744289 - - 12 - unc-51-like kinase 1 (C. elegans) protein-coding - ptr-miR-25 predicted by miR-25 (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (25026296) 3328 ptr-miR-29c miR-29abcd MIMAT0008082 miRNA PSME4 autophagy down Pan troglodytes prediction 9598 459229 - Ensembl:ENSPTRG00000011920 2A - proteasome (prosome, macropain) activator subunit 4 protein-coding - ptr-miR-29c predicted by miR-29b (Homo sapiens), and PSME4 predicted by PSME4 (Homo sapiens) according to Pubmed ID (25234165) 3329 ptr-miR-30c miR-30abcdef/30abe-5p/384-5p MIMAT0002614 miRNA ATG2B autophagy down Pan troglodytes prediction 9598 453143 - Ensembl:ENSPTRG00000006700 14 - autophagy related 2B protein-coding - ptr-miR-30c predicted by mir-30d (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (23274497) 3330 ptr-miR-17-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002693 miRNA ATG7 autophagy down Pan troglodytes prediction 9598 470747 - Ensembl:ENSPTRG00000014625 3 - autophagy related 7 protein-coding - ptr-miR-17-5p predicted by miR-17 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 3331 ptr-miR-93 miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0002770 miRNA ATG7 autophagy down Pan troglodytes prediction 9598 470747 - Ensembl:ENSPTRG00000014625 3 - autophagy related 7 protein-coding - ptr-miR-93 predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 3332 ptr-miR-520a miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008197 miRNA SQSTM1 autophagy down Pan troglodytes prediction 9598 462333 - Ensembl:ENSPTRG00000017626 5 - sequestosome 1 protein-coding - ptr-miR-520a predicted by miR-372 (Homo sapiens), and SQSTM1 predicted by SQSTM1 (Homo sapiens) according to Pubmed ID (24991827) 3333 ptr-miR-497 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0012803 miRNA BCL2L2 autophagy down Pan troglodytes prediction 9598 100611631 - Ensembl:ENSPTRG00000006167 14 - BCL2-like 2 protein-coding - ptr-miR-497 predicted by miR-15b (Mus musculus), and BCL2L2 predicted by Bcl2l2 (Mus musculus) according to Pubmed ID (21770019) 3334 ptr-miR-449a miR-34ac/34bc-5p/449abc/449c-5p MIMAT0008149 miRNA ATG9A autophagy down Pan troglodytes prediction 9598 742932 - Ensembl:ENSPTRG00000012943 2B - autophagy related 9A protein-coding - ptr-miR-449a predicted by miR-34a (Homo sapiens),miR-34a (Rattus norvegicus), and ATG9A predicted by Atg9a (Rattus norvegicus),ATG9A (Homo sapiens) according to Pubmed ID (22902544),(24728149),(24973144) 3335 ptr-miR-302c miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008088 miRNA SQSTM1 autophagy down Pan troglodytes prediction 9598 462333 - Ensembl:ENSPTRG00000017626 5 - sequestosome 1 protein-coding - ptr-miR-302c predicted by miR-372 (Homo sapiens), and SQSTM1 predicted by SQSTM1 (Homo sapiens) according to Pubmed ID (24991827) 3336 ptr-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002697 miRNA FYCO1 autophagy down Pan troglodytes prediction 9598 100614690 - Ensembl:ENSPTRG00000014842 3 - FYVE and coiled-coil domain containing 1 protein-coding - ptr-miR-20a predicted by miR-93 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3337 ptr-miR-302e miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008090 miRNA ATG7 autophagy down Pan troglodytes prediction 9598 470747 - Ensembl:ENSPTRG00000014625 3 - autophagy related 7 protein-coding - ptr-miR-302e predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 3338 ptr-miR-142 miR-142-3p MIMAT0008037 miRNA ATG16L1 autophagy down Pan troglodytes prediction 9598 460022 - Ensembl:ENSPTRG00000013051 2B - autophagy related 16-like 1 (S. cerevisiae) protein-coding - ptr-miR-142 predicted by miR-142-3p (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (24401604) 3339 ptr-miR-130a miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0008025 miRNA FYCO1 autophagy down Pan troglodytes prediction 9598 100614690 - Ensembl:ENSPTRG00000014842 3 - FYVE and coiled-coil domain containing 1 protein-coding - ptr-miR-130a predicted by miR-130b (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3340 ptr-miR-224 miR-224 MIMAT0002595 miRNA SMAD4 autophagy down Pan troglodytes prediction 9598 468537 - - 18 - SMAD family member 4 protein-coding - ptr-miR-224 predicted by miR-224 (Homo sapiens), and SMAD4 predicted by SMAD4 (Homo sapiens) according to Pubmed ID (23913306),(25068270) 3341 ptr-miR-30a-5p miR-30abcdef/30abe-5p/384-5p MIMAT0002371 miRNA BECN1 autophagy down Pan troglodytes prediction 9598 454700 beclin-1 Ensembl:ENSPTRG00000022819 17 - beclin 1, autophagy related protein-coding - ptr-miR-30a-5p predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and BECN1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 3342 ptr-miR-30b miR-30abcdef/30abe-5p/384-5p MIMAT0002214 miRNA BNIP3L autophagy down Pan troglodytes prediction 9598 464069 - Ensembl:ENSPTRG00000020097 8 - BCL2/adenovirus E1B 19kDa interacting protein 3-like protein-coding - ptr-miR-30b predicted by miR-30d (Homo sapiens), and BNIP3L predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 3343 ptr-miR-520e miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008201 miRNA ULK1 autophagy down Pan troglodytes prediction 9598 744289 - - 12 - unc-51-like kinase 1 (C. elegans) protein-coding - ptr-miR-520e predicted by miR-291 (Mus musculus), and ULK1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 3344 ptr-let-7g let-7/98/4458/4500 MIMAT0007942 miRNA OLR1 autophagy down Pan troglodytes prediction 9598 473362 - Ensembl:ENSPTRG00000004668 12 - oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding - ptr-let-7g predicted by let-7g (Mus musculus), and OLR1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 3345 ptr-miR-519d miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0008195 miRNA ULK1 autophagy down Pan troglodytes prediction 9598 744289 - - 12 - unc-51-like kinase 1 (C. elegans) protein-coding - ptr-miR-519d predicted by miR-106b (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 3346 ptr-miR-301a miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0008084 miRNA ATG2B autophagy down Pan troglodytes prediction 9598 453143 - Ensembl:ENSPTRG00000006700 14 - autophagy related 2B protein-coding - ptr-miR-301a predicted by miR-130a (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (22902544) 3347 ptr-miR-302d miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008089 miRNA ULK1 autophagy down Pan troglodytes prediction 9598 744289 - - 12 - unc-51-like kinase 1 (C. elegans) protein-coding - ptr-miR-302d predicted by miR-291 (Mus musculus), and ULK1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 3348 ptr-miR-15a miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0002654 miRNA ATG7 autophagy down Pan troglodytes prediction 9598 470747 - Ensembl:ENSPTRG00000014625 3 - autophagy related 7 protein-coding - ptr-miR-15a predicted by miR-16 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23143396) 3349 ptr-miR-181b miR-181abcd/4262 MIMAT0002625 miRNA TP63 autophagy down Pan troglodytes prediction 9598 460930 TP73L Ensembl:ENSPTRG00000015733 3 - tumor protein p63 protein-coding - ptr-miR-181b predicted by miR-181a (Homo sapiens), and TP63 predicted by TP63 (Homo sapiens) according to Pubmed ID (22356768) 3350 ptr-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0008069 miRNA FYCO1 autophagy down Pan troglodytes prediction 9598 100614690 - Ensembl:ENSPTRG00000014842 3 - FYVE and coiled-coil domain containing 1 protein-coding - ptr-miR-20b predicted by miR-93 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3351 ptr-let-7a let-7/98/4458/4500 MIMAT0007936 miRNA OLR1 autophagy down Pan troglodytes prediction 9598 473362 - Ensembl:ENSPTRG00000004668 12 - oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding - ptr-let-7a predicted by let-7g (Mus musculus), and OLR1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 3352 ptr-miR-211 miR-204/204b/211 MIMAT0008071 miRNA TRPM3 autophagy down Pan troglodytes prediction 9598 464521 - Ensembl:ENSPTRG00000021014 9 - transient receptor potential cation channel, subfamily M, member 3 protein-coding - ptr-miR-211 predicted by miR-204 (Homo sapiens), and TRPM3 predicted by TRPM3 (Homo sapiens) according to Pubmed ID (25517751) 3353 ptr-miR-519d miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0008195 miRNA ATG7 autophagy down Pan troglodytes prediction 9598 470747 - Ensembl:ENSPTRG00000014625 3 - autophagy related 7 protein-coding - ptr-miR-519d predicted by miR-17 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 3354 ptr-miR-25 miR-25/32/92abc/363/363-3p/367 MIMAT0002771 miRNA UVRAG autophagy down Pan troglodytes prediction 9598 451430 - Ensembl:ENSPTRG00000004088 11 - UV radiation resistance associated gene protein-coding - ptr-miR-25 predicted by miR-32 (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22135297) 3355 ptr-miR-301b miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0008085 miRNA FYCO1 autophagy down Pan troglodytes prediction 9598 100614690 - Ensembl:ENSPTRG00000014842 3 - FYVE and coiled-coil domain containing 1 protein-coding - ptr-miR-301b predicted by miR-130b (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3356 ptr-miR-155 miR-155 MIMAT0008048 miRNA GABARAPL1 autophagy down Pan troglodytes prediction 9598 737951 - - 12 - GABA(A) receptor-associated protein like 1 protein-coding - ptr-miR-155 predicted by miR-155 (Homo sapiens), and GABARAPL1 predicted by GABARAPL1 (Homo sapiens) according to Pubmed ID (20584899) 3357 ptr-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002769 miRNA HIF1A autophagy down Pan troglodytes prediction 9598 746195 SNAPC1 Ensembl:ENSPTRG00000006419 14 - hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding - ptr-miR-106b predicted by miR-20a (Homo sapiens), and HIF1A predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 3358 ptr-miR-152 miR-148ab-3p/152 MIMAT0008046 miRNA ATG14 autophagy down Pan troglodytes prediction 9598 744098 - Ensembl:ENSPTRG00000006375 14 - autophagy related 14 protein-coding - ptr-miR-152 predicted by miR-152 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (25650716) 3359 ptr-miR-449b miR-34ac/34bc-5p/449abc/449c-5p MIMAT0008150 miRNA ATG9A autophagy down Pan troglodytes prediction 9598 742932 - Ensembl:ENSPTRG00000012943 2B - autophagy related 9A protein-coding - ptr-miR-449b predicted by miR-34a (Homo sapiens),miR-34a (Rattus norvegicus), and ATG9A predicted by Atg9a (Rattus norvegicus),ATG9A (Homo sapiens) according to Pubmed ID (22902544),(24728149),(24973144) 3360 ptr-miR-93 miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0002770 miRNA SQSTM1 autophagy down Pan troglodytes prediction 9598 462333 - Ensembl:ENSPTRG00000017626 5 - sequestosome 1 protein-coding - ptr-miR-93 predicted by miR-372 (Homo sapiens), and SQSTM1 predicted by SQSTM1 (Homo sapiens) according to Pubmed ID (24991827) 3361 ptr-miR-181a miR-181abcd/4262 MIMAT0002505 miRNA ATG10 autophagy down Pan troglodytes prediction 9598 461768 - Ensembl:ENSPTRG00000017050 5 - autophagy related 10 protein-coding - ptr-miR-181a predicted by miR-181a (Homo sapiens), and ATG10 predicted by ATG10 (Homo sapiens) according to Pubmed ID (22356768) 3362 ptr-miR-148a miR-148ab-3p/152 MIMAT0008041 miRNA ATG14 autophagy down Pan troglodytes prediction 9598 744098 - Ensembl:ENSPTRG00000006375 14 - autophagy related 14 protein-coding - ptr-miR-148a predicted by miR-152 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (25650716) 3363 ptr-miR-320a miR-320abcd/4429 MIMAT0008093 miRNA ULK1 autophagy down Pan troglodytes prediction 9598 744289 - - 12 - unc-51-like kinase 1 (C. elegans) protein-coding - ptr-miR-320a predicted by miR-320a (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (23622248) 3364 ptr-miR-17-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002693 miRNA HIF1A autophagy down Pan troglodytes prediction 9598 746195 SNAPC1 Ensembl:ENSPTRG00000006419 14 - hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding - ptr-miR-17-5p predicted by miR-20a (Homo sapiens), and HIF1A predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 3365 ptr-miR-15b miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0002206 miRNA ATG14 autophagy down Pan troglodytes prediction 9598 744098 - Ensembl:ENSPTRG00000006375 14 - autophagy related 14 protein-coding - ptr-miR-15b predicted by miR-195 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 3366 ptr-miR-302d miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008089 miRNA ATG7 autophagy down Pan troglodytes prediction 9598 470747 - Ensembl:ENSPTRG00000014625 3 - autophagy related 7 protein-coding - ptr-miR-302d predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 3367 ptr-miR-519d miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0008195 miRNA FYCO1 autophagy down Pan troglodytes prediction 9598 100614690 - Ensembl:ENSPTRG00000014842 3 - FYVE and coiled-coil domain containing 1 protein-coding - ptr-miR-519d predicted by miR-93 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3368 ptr-miR-520d miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008200 miRNA ULK1 autophagy down Pan troglodytes prediction 9598 744289 - - 12 - unc-51-like kinase 1 (C. elegans) protein-coding - ptr-miR-520d predicted by miR-291 (Mus musculus), and ULK1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 3369 ptr-let-7b let-7/98/4458/4500 MIMAT0007937 miRNA OLR1 autophagy down Pan troglodytes prediction 9598 473362 - Ensembl:ENSPTRG00000004668 12 - oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding - ptr-let-7b predicted by let-7g (Mus musculus), and OLR1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 3370 ptr-miR-497 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0012803 miRNA ATG7 autophagy down Pan troglodytes prediction 9598 470747 - Ensembl:ENSPTRG00000014625 3 - autophagy related 7 protein-coding - ptr-miR-497 predicted by miR-16 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23143396) 3371 ptr-miR-520d miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008200 miRNA ATG7 autophagy down Pan troglodytes prediction 9598 470747 - Ensembl:ENSPTRG00000014625 3 - autophagy related 7 protein-coding - ptr-miR-520d predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 3372 ptr-let-7i let-7/98/4458/4500 MIMAT0007943 miRNA ATG4B autophagy down Pan troglodytes prediction 9598 748674 - - 2B - autophagy related 4B, cysteine peptidase protein-coding - ptr-let-7i predicted by let-7b (Homo sapiens), and ATG4B predicted by ATG4B (Homo sapiens) according to Pubmed ID (22135297) 3373 ptr-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002769 miRNA SQSTM1 autophagy down Pan troglodytes prediction 9598 462333 - Ensembl:ENSPTRG00000017626 5 - sequestosome 1 protein-coding - ptr-miR-106b predicted by miR-106b (Homo sapiens),miR-106 (Mus musculus), and SQSTM1 predicted by Sqstm1 (Mus musculus),SQSTM1 (Homo sapiens) according to Pubmed ID (21628417),(22441107),(25485521),(25617127) 3374 ptr-miR-181d miR-181abcd/4262 MIMAT0008049 miRNA UVRAG autophagy down Pan troglodytes prediction 9598 451430 - Ensembl:ENSPTRG00000004088 11 - UV radiation resistance associated gene protein-coding - ptr-miR-181d predicted by miR-181a (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22356768) 3375 ptr-miR-449a miR-34ac/34bc-5p/449abc/449c-5p MIMAT0008149 miRNA ATG4B autophagy down Pan troglodytes prediction 9598 748674 - - 2B - autophagy related 4B, cysteine peptidase protein-coding - ptr-miR-449a predicted by miR-34a (Homo sapiens), and ATG4B predicted by ATG4B (Homo sapiens) according to Pubmed ID (24755409) 3376 ptr-miR-29c miR-29abcd MIMAT0008082 miRNA ATG9A autophagy down Pan troglodytes prediction 9598 742932 - Ensembl:ENSPTRG00000012943 2B - autophagy related 9A protein-coding - ptr-miR-29c predicted by miR-29b (Bos taurus), and ATG9A predicted by ATG9A (Bos taurus) according to Pubmed ID (25234643) 3377 ptr-miR-204 miR-204/204b/211 MIMAT0002535 miRNA CAV1 autophagy down Pan troglodytes prediction 9598 463670 - Ensembl:ENSPTRG00000019613 7 - caveolin 1, caveolae protein, 22kDa protein-coding - ptr-miR-204 predicted by miR-204 (Homo sapiens), and CAV1 predicted by CAV1 (Homo sapiens) according to Pubmed ID (25517751) 3378 ptr-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002697 miRNA ULK1 autophagy down Pan troglodytes prediction 9598 744289 - - 12 - unc-51-like kinase 1 (C. elegans) protein-coding - ptr-miR-20a predicted by miR-106b (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 3379 ptr-miR-497 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0012803 miRNA ATG14 autophagy down Pan troglodytes prediction 9598 744098 - Ensembl:ENSPTRG00000006375 14 - autophagy related 14 protein-coding - ptr-miR-497 predicted by miR-195 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 3380 ptr-miR-195 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0008060 miRNA ATG7 autophagy down Pan troglodytes prediction 9598 470747 - Ensembl:ENSPTRG00000014625 3 - autophagy related 7 protein-coding - ptr-miR-195 predicted by miR-16 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23143396) 3381 ptr-miR-195 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0008060 miRNA ATG14 autophagy down Pan troglodytes prediction 9598 744098 - Ensembl:ENSPTRG00000006375 14 - autophagy related 14 protein-coding - ptr-miR-195 predicted by miR-195 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 3382 ptr-miR-106a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002800 miRNA HIF1A autophagy down Pan troglodytes prediction 9598 746195 SNAPC1 Ensembl:ENSPTRG00000006419 14 - hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding - ptr-miR-106a predicted by miR-20a (Homo sapiens), and HIF1A predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 3383 ptr-let-7e let-7/98/4458/4500 MIMAT0007940 miRNA IGF1R autophagy down Pan troglodytes prediction 9598 453676 - Ensembl:ENSPTRG00000007489 15 - insulin-like growth factor 1 receptor protein-coding - ptr-let-7e predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 3384 ptr-miR-454 miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0008156 miRNA ATG2B autophagy down Pan troglodytes prediction 9598 453143 - Ensembl:ENSPTRG00000006700 14 - autophagy related 2B protein-coding - ptr-miR-454 predicted by miR-130a (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (22902544) 3385 ptr-miR-181d miR-181abcd/4262 MIMAT0008049 miRNA TP63 autophagy down Pan troglodytes prediction 9598 460930 TP73L Ensembl:ENSPTRG00000015733 3 - tumor protein p63 protein-coding - ptr-miR-181d predicted by miR-181a (Homo sapiens), and TP63 predicted by TP63 (Homo sapiens) according to Pubmed ID (22356768) 3386 ptr-miR-301b miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0008085 miRNA ATG2B autophagy down Pan troglodytes prediction 9598 453143 - Ensembl:ENSPTRG00000006700 14 - autophagy related 2B protein-coding - ptr-miR-301b predicted by miR-130a (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (22902544) 3387 ptr-miR-302e miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008090 miRNA FYCO1 autophagy down Pan troglodytes prediction 9598 100614690 - Ensembl:ENSPTRG00000014842 3 - FYVE and coiled-coil domain containing 1 protein-coding - ptr-miR-302e predicted by miR-373 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3388 ptr-miR-32 miR-25/32/92abc/363/363-3p/367 MIMAT0002386 miRNA UVRAG autophagy down Pan troglodytes prediction 9598 451430 - Ensembl:ENSPTRG00000004088 11 - UV radiation resistance associated gene protein-coding - ptr-miR-32 predicted by miR-32 (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22135297) 3389 ptr-miR-301b miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0008085 miRNA RB1CC1 autophagy down Pan troglodytes prediction 9598 464173 - Ensembl:ENSPTRG00000020246 8 - RB1-inducible coiled-coil 1 protein-coding - ptr-miR-301b predicted by miR-133b (Homo sapiens), and RB1CC1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 3390 ptr-miR-144 miR-144 MIMAT0002262 miRNA MAPK1 autophagy down Pan troglodytes prediction 9598 458680 - - 22 - mitogen-activated protein kinase 1 protein-coding - ptr-miR-144 predicted by miR-144 (Homo sapiens), and MAPK1 predicted by MAPK1 (Homo sapiens) according to Pubmed ID (25060662) 3391 ptr-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0008069 miRNA HIF1A autophagy down Pan troglodytes prediction 9598 746195 SNAPC1 Ensembl:ENSPTRG00000006419 14 - hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding - ptr-miR-20b predicted by miR-20a (Homo sapiens), and HIF1A predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 3392 ptr-let-7b let-7/98/4458/4500 MIMAT0007937 miRNA ATG4B autophagy down Pan troglodytes prediction 9598 748674 - - 2B - autophagy related 4B, cysteine peptidase protein-coding - ptr-let-7b predicted by let-7b (Homo sapiens), and ATG4B predicted by ATG4B (Homo sapiens) according to Pubmed ID (22135297) 3393 ptr-miR-520e miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008201 miRNA SQSTM1 autophagy down Pan troglodytes prediction 9598 462333 - Ensembl:ENSPTRG00000017626 5 - sequestosome 1 protein-coding - ptr-miR-520e predicted by miR-372 (Homo sapiens), and SQSTM1 predicted by SQSTM1 (Homo sapiens) according to Pubmed ID (24991827) 3394 ptr-miR-182 miR-182 MIMAT0008050 miRNA FOXO3 autophagy down Pan troglodytes prediction 9598 462921 - - 6 - forkhead box O3 protein-coding - ptr-miR-182 predicted by miR-182 (Homo sapiens), and FOXO3 predicted by FOXO3 (Homo sapiens) according to Pubmed ID (24871856) 3395 ptr-miR-101 miR-101/101ab MIMAT0002430 miRNA EZH2 autophagy down Pan troglodytes prediction 9598 745437 - Ensembl:ENSPTRG00000019837 7 - enhancer of zeste homolog 2 (Drosophila) protein-coding - ptr-miR-101 predicted by miR-101 (Homo sapiens), and EZH2 predicted by EZH2 (Homo sapiens) according to Pubmed ID (24211739) 3396 ptr-miR-302c miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008088 miRNA ATG7 autophagy down Pan troglodytes prediction 9598 470747 - Ensembl:ENSPTRG00000014625 3 - autophagy related 7 protein-coding - ptr-miR-302c predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 3397 ptr-miR-137 miR-137/137ab MIMAT0008033 miRNA BNIP3L autophagy down Pan troglodytes prediction 9598 464069 - Ensembl:ENSPTRG00000020097 8 - BCL2/adenovirus E1B 19kDa interacting protein 3-like protein-coding - ptr-miR-137 predicted by miR-137 (Homo sapiens), and BNIP3L predicted by BNIP3L (Homo sapiens) according to Pubmed ID (24573672) 3398 ptr-miR-130a miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0008025 miRNA ATG2B autophagy down Pan troglodytes prediction 9598 453143 - Ensembl:ENSPTRG00000006700 14 - autophagy related 2B protein-coding - ptr-miR-130a predicted by miR-130a (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (22902544) 3399 ptr-miR-195 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0008060 miRNA BCL2L2 autophagy down Pan troglodytes prediction 9598 100611631 - Ensembl:ENSPTRG00000006167 14 - BCL2-like 2 protein-coding - ptr-miR-195 predicted by miR-15b (Mus musculus), and BCL2L2 predicted by Bcl2l2 (Mus musculus) according to Pubmed ID (21770019) 3400 ptr-miR-29b miR-29abcd MIMAT0002435 miRNA ATG14 autophagy down Pan troglodytes prediction 9598 744098 - Ensembl:ENSPTRG00000006375 14 - autophagy related 14 protein-coding - ptr-miR-29b predicted by miR-29b (Bos taurus), and ATG14 predicted by ATG14 (Bos taurus) according to Pubmed ID (25234643) 3401 ptr-miR-30b miR-30abcdef/30abe-5p/384-5p MIMAT0002214 miRNA BECN1 autophagy down Pan troglodytes prediction 9598 454700 beclin-1 Ensembl:ENSPTRG00000022819 17 - beclin 1, autophagy related protein-coding - ptr-miR-30b predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and BECN1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 3402 ptr-miR-520a miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008197 miRNA ULK1 autophagy down Pan troglodytes prediction 9598 744289 - - 12 - unc-51-like kinase 1 (C. elegans) protein-coding - ptr-miR-520a predicted by miR-291 (Mus musculus), and ULK1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 3403 ptr-miR-375 miR-375 MIMAT0008125 miRNA YWHAZ autophagy down Pan troglodytes prediction 9598 472830 - - 8 - tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide protein-coding - ptr-miR-375 predicted by miR-375 (Homo sapiens), and YWHAZ predicted by YWHAZ (Homo sapiens) according to Pubmed ID (22606351) 3404 ptr-miR-92 miR-25/32/92abc/363/363-3p/367 MIMAT0002699 miRNA UVRAG autophagy down Pan troglodytes prediction 9598 451430 - Ensembl:ENSPTRG00000004088 11 - UV radiation resistance associated gene protein-coding - ptr-miR-92 predicted by miR-32 (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22135297) 3405 ptr-miR-30a-5p miR-30abcdef/30abe-5p/384-5p MIMAT0002371 miRNA ATG5 autophagy down Pan troglodytes prediction 9598 462905 APG5L Ensembl:ENSPTRG00000018458 6 - autophagy related 5 protein-coding - ptr-miR-30a-5p predicted by miR-30a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22395361),(22617440),(22902544),(23274497),(24148619) 3406 ptr-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002769 miRNA FYCO1 autophagy down Pan troglodytes prediction 9598 100614690 - Ensembl:ENSPTRG00000014842 3 - FYVE and coiled-coil domain containing 1 protein-coding - ptr-miR-106b predicted by miR-93 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3407 ptr-miR-372 miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008122 miRNA FYCO1 autophagy down Pan troglodytes prediction 9598 100614690 - Ensembl:ENSPTRG00000014842 3 - FYVE and coiled-coil domain containing 1 protein-coding - ptr-miR-372 predicted by miR-373 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3408 ptr-miR-302e miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008090 miRNA SQSTM1 autophagy down Pan troglodytes prediction 9598 462333 - Ensembl:ENSPTRG00000017626 5 - sequestosome 1 protein-coding - ptr-miR-302e predicted by miR-372 (Homo sapiens), and SQSTM1 predicted by SQSTM1 (Homo sapiens) according to Pubmed ID (24991827) 3409 ptr-miR-30d miR-30abcdef/30abe-5p/384-5p MIMAT0002617 miRNA BECN1 autophagy down Pan troglodytes prediction 9598 454700 beclin-1 Ensembl:ENSPTRG00000022819 17 - beclin 1, autophagy related protein-coding - ptr-miR-30d predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and BECN1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 3410 ptr-miR-519d miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0008195 miRNA HIF1A autophagy down Pan troglodytes prediction 9598 746195 SNAPC1 Ensembl:ENSPTRG00000006419 14 - hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding - ptr-miR-519d predicted by miR-20a (Homo sapiens), and HIF1A predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 3411 ptr-miR-506 miR-124/124ab/506 MIMAT0005770 miRNA ANTXR2 autophagy down Pan troglodytes prediction 9598 471191 - - 4 - anthrax toxin receptor 2 protein-coding - ptr-miR-506 predicted by miR-124 (Homo sapiens), and ANTXR2 predicted by ANTXR2 (Homo sapiens) according to Pubmed ID (25736362) 3412 ptr-miR-374b miR-374ab MIMAT0008124 miRNA UVRAG autophagy down Pan troglodytes prediction 9598 451430 - Ensembl:ENSPTRG00000004088 11 - UV radiation resistance associated gene protein-coding - ptr-miR-374b predicted by miR-374a (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22356768) 3413 ptr-miR-30c miR-30abcdef/30abe-5p/384-5p MIMAT0002614 miRNA ATG5 autophagy down Pan troglodytes prediction 9598 462905 APG5L Ensembl:ENSPTRG00000018458 6 - autophagy related 5 protein-coding - ptr-miR-30c predicted by miR-30a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22395361),(22617440),(22902544),(23274497),(24148619) 3414 ptr-miR-30e miR-30abcdef/30abe-5p/384-5p MIMAT0008092 miRNA ATG2B autophagy down Pan troglodytes prediction 9598 453143 - Ensembl:ENSPTRG00000006700 14 - autophagy related 2B protein-coding - ptr-miR-30e predicted by mir-30d (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (23274497) 3415 ptr-miR-143 miR-143/1721/4770 MIMAT0002257 miRNA ATG2B autophagy down Pan troglodytes prediction 9598 453143 - Ensembl:ENSPTRG00000006700 14 - autophagy related 2B protein-coding - ptr-miR-143 predicted by miR-143 (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (25322940) 3416 ptr-let-7a let-7/98/4458/4500 MIMAT0007936 miRNA IGF1R autophagy down Pan troglodytes prediction 9598 453676 - Ensembl:ENSPTRG00000007489 15 - insulin-like growth factor 1 receptor protein-coding - ptr-let-7a predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 3417 ptr-miR-181b miR-181abcd/4262 MIMAT0002625 miRNA ATG10 autophagy down Pan troglodytes prediction 9598 461768 - Ensembl:ENSPTRG00000017050 5 - autophagy related 10 protein-coding - ptr-miR-181b predicted by miR-181a (Homo sapiens), and ATG10 predicted by ATG10 (Homo sapiens) according to Pubmed ID (22356768) 3418 ptr-miR-302b miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008087 miRNA ATG7 autophagy down Pan troglodytes prediction 9598 470747 - Ensembl:ENSPTRG00000014625 3 - autophagy related 7 protein-coding - ptr-miR-302b predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 3419 ptr-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002697 miRNA ATG16L1 autophagy down Pan troglodytes prediction 9598 460022 - Ensembl:ENSPTRG00000013051 2B - autophagy related 16-like 1 (S. cerevisiae) protein-coding - ptr-miR-20a predicted by miR-106b (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 3420 ptr-miR-181b miR-181abcd/4262 MIMAT0002625 miRNA UVRAG autophagy down Pan troglodytes prediction 9598 451430 - Ensembl:ENSPTRG00000004088 11 - UV radiation resistance associated gene protein-coding - ptr-miR-181b predicted by miR-181a (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22356768) 3421 ptr-let-7e let-7/98/4458/4500 MIMAT0007940 miRNA ATG4B autophagy down Pan troglodytes prediction 9598 748674 - - 2B - autophagy related 4B, cysteine peptidase protein-coding - ptr-let-7e predicted by let-7b (Homo sapiens), and ATG4B predicted by ATG4B (Homo sapiens) according to Pubmed ID (22135297) 3422 ptr-miR-93 miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0002770 miRNA FYCO1 autophagy down Pan troglodytes prediction 9598 100614690 - Ensembl:ENSPTRG00000014842 3 - FYVE and coiled-coil domain containing 1 protein-coding - ptr-miR-93 predicted by miR-373 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3423 ptr-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002769 miRNA ATG16L1 autophagy down Pan troglodytes prediction 9598 460022 - Ensembl:ENSPTRG00000013051 2B - autophagy related 16-like 1 (S. cerevisiae) protein-coding - ptr-miR-106b predicted by miR-106b (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 3424 ptr-miR-17-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002693 miRNA ULK1 autophagy down Pan troglodytes prediction 9598 744289 - - 12 - unc-51-like kinase 1 (C. elegans) protein-coding - ptr-miR-17-5p predicted by miR-106b (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 3425 ptr-let-7a let-7/98/4458/4500 MIMAT0007936 miRNA ATG4B autophagy down Pan troglodytes prediction 9598 748674 - - 2B - autophagy related 4B, cysteine peptidase protein-coding - ptr-let-7a predicted by let-7b (Homo sapiens), and ATG4B predicted by ATG4B (Homo sapiens) according to Pubmed ID (22135297) 3426 ptr-miR-181c miR-181abcd/4262 MIMAT0002510 miRNA TP63 autophagy down Pan troglodytes prediction 9598 460930 TP73L Ensembl:ENSPTRG00000015733 3 - tumor protein p63 protein-coding - ptr-miR-181c predicted by miR-181a (Homo sapiens), and TP63 predicted by TP63 (Homo sapiens) according to Pubmed ID (22356768) 3427 ptr-miR-302d miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008089 miRNA SQSTM1 autophagy down Pan troglodytes prediction 9598 462333 - Ensembl:ENSPTRG00000017626 5 - sequestosome 1 protein-coding - ptr-miR-302d predicted by miR-372 (Homo sapiens), and SQSTM1 predicted by SQSTM1 (Homo sapiens) according to Pubmed ID (24991827) 3428 ptr-miR-374a miR-374ab MIMAT0008123 miRNA UVRAG autophagy down Pan troglodytes prediction 9598 451430 - Ensembl:ENSPTRG00000004088 11 - UV radiation resistance associated gene protein-coding - ptr-miR-374a predicted by miR-374a (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22356768) 3429 ptr-miR-302e miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008090 miRNA ULK1 autophagy down Pan troglodytes prediction 9598 744289 - - 12 - unc-51-like kinase 1 (C. elegans) protein-coding - ptr-miR-302e predicted by miR-291 (Mus musculus), and ULK1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 3430 ptr-miR-30e miR-30abcdef/30abe-5p/384-5p MIMAT0008092 miRNA BECN1 autophagy down Pan troglodytes prediction 9598 454700 beclin-1 Ensembl:ENSPTRG00000022819 17 - beclin 1, autophagy related protein-coding - ptr-miR-30e predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and BECN1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 3431 ptr-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0008069 miRNA ATG7 autophagy down Pan troglodytes prediction 9598 470747 - Ensembl:ENSPTRG00000014625 3 - autophagy related 7 protein-coding - ptr-miR-20b predicted by miR-17 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 3432 ptr-miR-30d miR-30abcdef/30abe-5p/384-5p MIMAT0002617 miRNA BNIP3L autophagy down Pan troglodytes prediction 9598 464069 - Ensembl:ENSPTRG00000020097 8 - BCL2/adenovirus E1B 19kDa interacting protein 3-like protein-coding - ptr-miR-30d predicted by miR-30d (Homo sapiens), and BNIP3L predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 3433 ptr-miR-7 miR-7/7ab MIMAT0002485 miRNA EGFR autophagy down Pan troglodytes prediction 9598 463415 - Ensembl:ENSPTRG00000019196 7 - epidermal growth factor receptor protein-coding - ptr-miR-7 predicted by miR-7 (Homo sapiens), and EGFR predicted by EGFR (Homo sapiens) according to Pubmed ID (22492316) 3434 ptr-miR-181a miR-181abcd/4262 MIMAT0002505 miRNA TP63 autophagy down Pan troglodytes prediction 9598 460930 TP73L Ensembl:ENSPTRG00000015733 3 - tumor protein p63 protein-coding - ptr-miR-181a predicted by miR-181a (Homo sapiens), and TP63 predicted by TP63 (Homo sapiens) according to Pubmed ID (22356768) 3435 ptr-miR-30b miR-30abcdef/30abe-5p/384-5p MIMAT0002214 miRNA ATG2B autophagy down Pan troglodytes prediction 9598 453143 - Ensembl:ENSPTRG00000006700 14 - autophagy related 2B protein-coding - ptr-miR-30b predicted by mir-30d (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (23274497) 3436 ptr-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002697 miRNA ATG7 autophagy down Pan troglodytes prediction 9598 470747 - Ensembl:ENSPTRG00000014625 3 - autophagy related 7 protein-coding - ptr-miR-20a predicted by miR-17 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 3437 ptr-miR-449b miR-34ac/34bc-5p/449abc/449c-5p MIMAT0008150 miRNA ATG4B autophagy down Pan troglodytes prediction 9598 748674 - - 2B - autophagy related 4B, cysteine peptidase protein-coding - ptr-miR-449b predicted by miR-34a (Homo sapiens), and ATG4B predicted by ATG4B (Homo sapiens) according to Pubmed ID (24755409) 3438 ptr-miR-520e miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008201 miRNA ATG7 autophagy down Pan troglodytes prediction 9598 470747 - Ensembl:ENSPTRG00000014625 3 - autophagy related 7 protein-coding - ptr-miR-520e predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 3439 ptr-miR-181c miR-181abcd/4262 MIMAT0002510 miRNA ATG5 autophagy down Pan troglodytes prediction 9598 462905 APG5L Ensembl:ENSPTRG00000018458 6 - autophagy related 5 protein-coding - ptr-miR-181c predicted by miR-181a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22356768),(22902544),(23322078) 3440 ptr-miR-16 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0002655 miRNA BCL2L2 autophagy down Pan troglodytes prediction 9598 100611631 - Ensembl:ENSPTRG00000006167 14 - BCL2-like 2 protein-coding - ptr-miR-16 predicted by miR-15b (Mus musculus), and BCL2L2 predicted by Bcl2l2 (Mus musculus) according to Pubmed ID (21770019) 3441 ptr-miR-181b miR-181abcd/4262 MIMAT0002625 miRNA ATG5 autophagy down Pan troglodytes prediction 9598 462905 APG5L Ensembl:ENSPTRG00000018458 6 - autophagy related 5 protein-coding - ptr-miR-181b predicted by miR-181a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22356768),(22902544),(23322078) 3442 ptr-miR-320b miR-320abcd/4429 MIMAT0008094 miRNA ULK1 autophagy down Pan troglodytes prediction 9598 744289 - - 12 - unc-51-like kinase 1 (C. elegans) protein-coding - ptr-miR-320b predicted by miR-320a (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (23622248) 3443 ptr-miR-520e miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0008201 miRNA FYCO1 autophagy down Pan troglodytes prediction 9598 100614690 - Ensembl:ENSPTRG00000014842 3 - FYVE and coiled-coil domain containing 1 protein-coding - ptr-miR-520e predicted by miR-373 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3444 ptr-miR-148b miR-148ab-3p/152 MIMAT0008042 miRNA ATG14 autophagy down Pan troglodytes prediction 9598 744098 - Ensembl:ENSPTRG00000006375 14 - autophagy related 14 protein-coding - ptr-miR-148b predicted by miR-152 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (25650716) 3445 ptr-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002697 miRNA HIF1A autophagy down Pan troglodytes prediction 9598 746195 SNAPC1 Ensembl:ENSPTRG00000006419 14 - hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding - ptr-miR-20a predicted by miR-20a (Homo sapiens), and HIF1A predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 3446 ptr-miR-106a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002800 miRNA ATG16L1 autophagy down Pan troglodytes prediction 9598 460022 - Ensembl:ENSPTRG00000013051 2B - autophagy related 16-like 1 (S. cerevisiae) protein-coding - ptr-miR-106a predicted by miR-106b (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 3447 hsa-miR-302c miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0000717 miRNA SQSTM1 autophagy down Homo sapiens prediction 9606 8878 A170|OSIL|PDB3|ZIP3|p60|p62|p62B HGNC:11280|MIM:601530|Ensembl:ENSG00000161011|HPRD:03319|Vega:OTTHUMG00000150643 5 5q35 sequestosome 1 protein-coding sequestosome 1 hsa-miR-302c predicted by miR-372 (Homo sapiens), and SQSTM1 predicted by SQSTM1 (Homo sapiens) according to Pubmed ID (24991827) 3448 hsa-miR-30e miR-30abcdef/30abe-5p/384-5p MIMAT0000692 miRNA MAP1LC3B autophagy down Homo sapiens prediction 9606 81631 ATG8F|LC3B|MAP1A/1BLC3|MAP1LC3B-a HGNC:13352|MIM:609604|Ensembl:ENSG00000140941|HPRD:14358|Vega:OTTHUMG00000137654 16 16q24.2 microtubule-associated protein 1 light chain 3 beta protein-coding microtubule-associated protein 1 light chain 3 beta hsa-miR-30e predicted by miR-30a (Homo sapiens), and MAP1LC3B predicted by MAP1LC3B (Homo sapiens) according to Pubmed ID (22135297) 3449 hsa-let-7b let-7/98/4458/4500 MIMAT0000063 miRNA OLR1 autophagy down Homo sapiens prediction 9606 4973 CLEC8A|LOX1|LOXIN|SCARE1|SLOX1 HGNC:8133|MIM:602601|Ensembl:ENSG00000173391|HPRD:04003|Vega:OTTHUMG00000168527 12 12p13.2-p12.3 oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding oxidized low density lipoprotein (lectin-like) receptor 1 hsa-let-7b predicted by let-7g (Mus musculus), and OLR1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 3450 hsa-let-7e let-7/98/4458/4500 MIMAT0000066 miRNA OLR1 autophagy down Homo sapiens prediction 9606 4973 CLEC8A|LOX1|LOXIN|SCARE1|SLOX1 HGNC:8133|MIM:602601|Ensembl:ENSG00000173391|HPRD:04003|Vega:OTTHUMG00000168527 12 12p13.2-p12.3 oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding oxidized low density lipoprotein (lectin-like) receptor 1 hsa-let-7e predicted by let-7g (Mus musculus), and OLR1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 3451 hsa-miR-195 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000461 miRNA BCL2L2 autophagy down Homo sapiens prediction 9606 599 BCL-W|BCL2-L-2|BCLW|PPP1R51 HGNC:995|MIM:601931|Ensembl:ENSG00000129473|HPRD:03569|Vega:OTTHUMG00000028738 14 14q11.2-q12 BCL2-like 2 protein-coding BCL2-like 2 hsa-miR-195 predicted by miR-15b (Mus musculus), and BCL2L2 predicted by Bcl2l2 (Mus musculus) according to Pubmed ID (21770019) 3452 hsa-miR-106a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000103 miRNA FYCO1 autophagy down Homo sapiens prediction 9606 79443 CATC2|CTRCT18|RUFY3|ZFYVE7 HGNC:14673|MIM:607182|Ensembl:ENSG00000163820|HPRD:06215|Vega:OTTHUMG00000133447 3 3p21.31 FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 hsa-miR-106a predicted by miR-93 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3453 hsa-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0001413 miRNA BECN1 autophagy down Homo sapiens prediction 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related hsa-miR-20b predicted by miR-17-5p (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (24755562),(25435430),(25485521) 3454 hsa-miR-4295 miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0016844 miRNA FYCO1 autophagy down Homo sapiens prediction 9606 79443 CATC2|CTRCT18|RUFY3|ZFYVE7 HGNC:14673|MIM:607182|Ensembl:ENSG00000163820|HPRD:06215|Vega:OTTHUMG00000133447 3 3p21.31 FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 hsa-miR-4295 predicted by miR-130b (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3455 hsa-miR-373 miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0000726 miRNA ATG7 autophagy down Homo sapiens prediction 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 hsa-miR-373 predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 3456 hsa-miR-372 miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0000724 miRNA ATG7 autophagy down Homo sapiens prediction 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 hsa-miR-372 predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 3457 hsa-miR-29c miR-29abcd MIMAT0000681 miRNA ATG9A autophagy down Homo sapiens prediction 9606 79065 APG9L1|MGD3208|mATG9 HGNC:22408|MIM:612204|Ensembl:ENSG00000198925|HPRD:07979|Vega:OTTHUMG00000154557 2 2q35 autophagy related 9A protein-coding autophagy related 9A hsa-miR-29c predicted by miR-29b (Bos taurus), and ATG9A predicted by ATG9A (Bos taurus) according to Pubmed ID (25234643) 3458 hsa-miR-3666 miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0018088 miRNA ATG2B autophagy down Homo sapiens prediction 9606 55102 C14orf103 HGNC:20187|Ensembl:ENSG00000066739|HPRD:12626|Vega:OTTHUMG00000149933 14 14q32.2 autophagy related 2B protein-coding autophagy related 2B hsa-miR-3666 predicted by miR-130a (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (22902544) 3459 hsa-let-7c let-7/98/4458/4500 MIMAT0000064 miRNA ATG4B autophagy down Homo sapiens prediction 9606 23192 APG4B|AUTL1 HGNC:20790|MIM:611338|Ensembl:ENSG00000168397|HPRD:16499|Vega:OTTHUMG00000151514 2 2q37.3 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase hsa-let-7c predicted by let-7b (Homo sapiens), and ATG4B predicted by ATG4B (Homo sapiens) according to Pubmed ID (22135297) 3460 hsa-miR-449a miR-34ac/34bc-5p/449abc/449c-5p MIMAT0001541 miRNA ATG4B autophagy down Homo sapiens prediction 9606 23192 APG4B|AUTL1 HGNC:20790|MIM:611338|Ensembl:ENSG00000168397|HPRD:16499|Vega:OTTHUMG00000151514 2 2q37.3 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase hsa-miR-449a predicted by miR-34a (Homo sapiens), and ATG4B predicted by ATG4B (Homo sapiens) according to Pubmed ID (24755409) 3461 hsa-miR-106a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000103 miRNA HIF1A autophagy down Homo sapiens prediction 9606 3091 HIF-1A|HIF-1alpha|HIF1|HIF1-ALPHA|MOP1|PASD8|bHLHe78 HGNC:4910|MIM:603348|Ensembl:ENSG00000100644|HPRD:04517|Vega:OTTHUMG00000140344 14 14q23.2 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) hsa-miR-106a predicted by miR-20a (Homo sapiens), and HIF1A predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 3462 hsa-miR-15a miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000068 miRNA ATG14 autophagy down Homo sapiens prediction 9606 22863 ATG14L|BARKOR|KIAA0831 HGNC:19962|MIM:613515|Ensembl:ENSG00000126775|HPRD:13820|Vega:OTTHUMG00000172129 14 14q22.3 autophagy related 14 protein-coding autophagy related 14 hsa-miR-15a predicted by miR-195 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 3463 hsa-miR-497 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0002820 miRNA ATG14 autophagy down Homo sapiens prediction 9606 22863 ATG14L|BARKOR|KIAA0831 HGNC:19962|MIM:613515|Ensembl:ENSG00000126775|HPRD:13820|Vega:OTTHUMG00000172129 14 14q22.3 autophagy related 14 protein-coding autophagy related 14 hsa-miR-497 predicted by miR-195 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 3464 hsa-miR-520e miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0002825 miRNA SQSTM1 autophagy down Homo sapiens prediction 9606 8878 A170|OSIL|PDB3|ZIP3|p60|p62|p62B HGNC:11280|MIM:601530|Ensembl:ENSG00000161011|HPRD:03319|Vega:OTTHUMG00000150643 5 5q35 sequestosome 1 protein-coding sequestosome 1 hsa-miR-520e predicted by miR-372 (Homo sapiens), and SQSTM1 predicted by SQSTM1 (Homo sapiens) according to Pubmed ID (24991827) 3465 hsa-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000075 miRNA ULK1 autophagy down Homo sapiens prediction 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 hsa-miR-20a predicted by miR-106b (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 3466 hsa-miR-99b miR-99ab/100 MIMAT0000689 miRNA MTOR autophagy down Homo sapiens prediction 9606 2475 FRAP|FRAP1|FRAP2|RAFT1|RAPT1 HGNC:3942|MIM:601231|Ensembl:ENSG00000198793|HPRD:03134|Vega:OTTHUMG00000002001 1 1p36.2 mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) hsa-miR-99b predicted by miR-100 (Homo sapiens), and MTOR predicted by MTOR (Homo sapiens) according to Pubmed ID (25026290) 3467 hsa-miR-372 miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0000724 miRNA ULK1 autophagy down Homo sapiens prediction 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 hsa-miR-372 predicted by miR-291 (Mus musculus), and ULK1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 3468 hsa-miR-520d-3p miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0002856 miRNA ULK1 autophagy down Homo sapiens prediction 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 hsa-miR-520d-3p predicted by miR-291 (Mus musculus), and ULK1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 3469 hsa-miR-4458 let-7/98/4458/4500 MIMAT0018980 miRNA IGF1R autophagy down Homo sapiens prediction 9606 3480 CD221|IGFIR|IGFR|JTK13 HGNC:5465|MIM:147370|Ensembl:ENSG00000140443|HPRD:00932|Vega:OTTHUMG00000149851 15 15q26.3 insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor hsa-miR-4458 predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 3470 hsa-miR-15a miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000068 miRNA ATG7 autophagy down Homo sapiens prediction 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 hsa-miR-15a predicted by miR-16 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23143396) 3471 hsa-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000680 miRNA BECN1 autophagy down Homo sapiens prediction 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related hsa-miR-106b predicted by miR-17-5p (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (24755562),(25435430),(25485521) 3472 hsa-miR-21 miR-21/590-5p MIMAT0000076 miRNA PTEN autophagy down Homo sapiens prediction 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog hsa-miR-21 predicted by miR-21 (Rattus norvegicus), and PTEN predicted by Pten (Rattus norvegicus) according to Pubmed ID (25689721) 3473 hsa-miR-211 miR-204/204b/211 MIMAT0000268 miRNA MAP1LC3B autophagy down Homo sapiens prediction 9606 81631 ATG8F|LC3B|MAP1A/1BLC3|MAP1LC3B-a HGNC:13352|MIM:609604|Ensembl:ENSG00000140941|HPRD:14358|Vega:OTTHUMG00000137654 16 16q24.2 microtubule-associated protein 1 light chain 3 beta protein-coding microtubule-associated protein 1 light chain 3 beta hsa-miR-211 predicted by miR-204 (Homo sapiens),miR-204 (Rattus norvegicus), and MAP1LC3B predicted by Map1lc3b (Rattus norvegicus),MAP1LC3B (Homo sapiens) according to Pubmed ID (21316776),(21631941),(22516261),(25209181),(25517751) 3474 hsa-miR-520a-3p miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0002834 miRNA SQSTM1 autophagy down Homo sapiens prediction 9606 8878 A170|OSIL|PDB3|ZIP3|p60|p62|p62B HGNC:11280|MIM:601530|Ensembl:ENSG00000161011|HPRD:03319|Vega:OTTHUMG00000150643 5 5q35 sequestosome 1 protein-coding sequestosome 1 hsa-miR-520a-3p predicted by miR-372 (Homo sapiens), and SQSTM1 predicted by SQSTM1 (Homo sapiens) according to Pubmed ID (24991827) 3475 hsa-miR-181c miR-181abcd/4262 MIMAT0000258 miRNA ATG5 autophagy down Homo sapiens prediction 9606 9474 APG5|APG5-LIKE|APG5L|ASP|hAPG5 HGNC:589|MIM:604261|Ensembl:ENSG00000057663|HPRD:16051|Vega:OTTHUMG00000016193 6 6q21 autophagy related 5 protein-coding autophagy related 5 hsa-miR-181c predicted by miR-181a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22356768),(22902544),(23322078) 3476 hsa-let-7g let-7/98/4458/4500 MIMAT0000414 miRNA IGF1R autophagy down Homo sapiens prediction 9606 3480 CD221|IGFIR|IGFR|JTK13 HGNC:5465|MIM:147370|Ensembl:ENSG00000140443|HPRD:00932|Vega:OTTHUMG00000149851 15 15q26.3 insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor hsa-let-7g predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 3477 hsa-miR-30d miR-30abcdef/30abe-5p/384-5p MIMAT0000245 miRNA BECN1 autophagy down Homo sapiens prediction 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related hsa-miR-30d predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and BECN1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 3478 hsa-let-7g let-7/98/4458/4500 MIMAT0000414 miRNA OLR1 autophagy down Homo sapiens prediction 9606 4973 CLEC8A|LOX1|LOXIN|SCARE1|SLOX1 HGNC:8133|MIM:602601|Ensembl:ENSG00000173391|HPRD:04003|Vega:OTTHUMG00000168527 12 12p13.2-p12.3 oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding oxidized low density lipoprotein (lectin-like) receptor 1 hsa-let-7g predicted by let-7g (Mus musculus), and OLR1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 3479 hsa-miR-302b miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0000715 miRNA SQSTM1 autophagy down Homo sapiens prediction 9606 8878 A170|OSIL|PDB3|ZIP3|p60|p62|p62B HGNC:11280|MIM:601530|Ensembl:ENSG00000161011|HPRD:03319|Vega:OTTHUMG00000150643 5 5q35 sequestosome 1 protein-coding sequestosome 1 hsa-miR-302b predicted by miR-372 (Homo sapiens), and SQSTM1 predicted by SQSTM1 (Homo sapiens) according to Pubmed ID (24991827) 3480 hsa-miR-106a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000103 miRNA SQSTM1 autophagy down Homo sapiens prediction 9606 8878 A170|OSIL|PDB3|ZIP3|p60|p62|p62B HGNC:11280|MIM:601530|Ensembl:ENSG00000161011|HPRD:03319|Vega:OTTHUMG00000150643 5 5q35 sequestosome 1 protein-coding sequestosome 1 hsa-miR-106a predicted by miR-106b (Homo sapiens),miR-106 (Mus musculus), and SQSTM1 predicted by Sqstm1 (Mus musculus),SQSTM1 (Homo sapiens) according to Pubmed ID (21628417),(22441107),(25485521),(25617127) 3481 hsa-miR-93 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000093 miRNA ATG5 autophagy down Homo sapiens prediction 9606 9474 APG5|APG5-LIKE|APG5L|ASP|hAPG5 HGNC:589|MIM:604261|Ensembl:ENSG00000057663|HPRD:16051|Vega:OTTHUMG00000016193 6 6q21 autophagy related 5 protein-coding autophagy related 5 hsa-miR-93 predicted by miR-20a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (25485521) 3482 hsa-miR-367 miR-25/32/92abc/363/363-3p/367 MIMAT0000719 miRNA ULK1 autophagy down Homo sapiens prediction 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 hsa-miR-367 predicted by miR-25 (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (25026296) 3483 hsa-miR-130a miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0000425 miRNA RB1CC1 autophagy down Homo sapiens prediction 9606 9821 ATG17|CC1|FIP200|PPP1R131 HGNC:15574|MIM:606837|Ensembl:ENSG00000023287|HPRD:06019|Vega:OTTHUMG00000164268 8 8q11 RB1-inducible coiled-coil 1 protein-coding RB1-inducible coiled-coil 1 hsa-miR-130a predicted by miR-133b (Homo sapiens), and RB1CC1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 3484 hsa-miR-30d miR-30abcdef/30abe-5p/384-5p MIMAT0000245 miRNA ATG5 autophagy down Homo sapiens prediction 9606 9474 APG5|APG5-LIKE|APG5L|ASP|hAPG5 HGNC:589|MIM:604261|Ensembl:ENSG00000057663|HPRD:16051|Vega:OTTHUMG00000016193 6 6q21 autophagy related 5 protein-coding autophagy related 5 hsa-miR-30d predicted by miR-30a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22395361),(22617440),(22902544),(23274497),(24148619) 3485 hsa-miR-374b miR-374ab MIMAT0004955 miRNA UVRAG autophagy down Homo sapiens prediction 9606 7405 DHTX|VPS38|p63 HGNC:12640|MIM:602493|HPRD:03929 11 11q13.5 UV radiation resistance associated protein-coding UV radiation resistance associated hsa-miR-374b predicted by miR-374a (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22356768) 3486 hsa-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000680 miRNA FYCO1 autophagy down Homo sapiens prediction 9606 79443 CATC2|CTRCT18|RUFY3|ZFYVE7 HGNC:14673|MIM:607182|Ensembl:ENSG00000163820|HPRD:06215|Vega:OTTHUMG00000133447 3 3p21.31 FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 hsa-miR-106b predicted by miR-93 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3487 hsa-miR-30b miR-30abcdef/30abe-5p/384-5p MIMAT0000420 miRNA BNIP3L autophagy down Homo sapiens prediction 9606 665 BNIP3a|NIX HGNC:1085|MIM:605368|Ensembl:ENSG00000104765|HPRD:07288|Vega:OTTHUMG00000099433 8 8p21 BCL2/adenovirus E1B 19kDa interacting protein 3-like protein-coding BCL2/adenovirus E1B 19kDa interacting protein 3-like hsa-miR-30b predicted by miR-30d (Homo sapiens), and BNIP3L predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 3488 hsa-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000680 miRNA SQSTM1 autophagy down Homo sapiens prediction 9606 8878 A170|OSIL|PDB3|ZIP3|p60|p62|p62B HGNC:11280|MIM:601530|Ensembl:ENSG00000161011|HPRD:03319|Vega:OTTHUMG00000150643 5 5q35 sequestosome 1 protein-coding sequestosome 1 hsa-miR-106b predicted by miR-106b (Homo sapiens),miR-106 (Mus musculus), and SQSTM1 predicted by Sqstm1 (Mus musculus),SQSTM1 (Homo sapiens) according to Pubmed ID (21628417),(22441107),(25485521),(25617127) 3489 hsa-miR-92a miR-25/32/92abc/363/363-3p/367 MIMAT0000092 miRNA ULK1 autophagy down Homo sapiens prediction 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 hsa-miR-92a predicted by miR-25 (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (25026296) 3490 hsa-miR-106a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000103 miRNA ULK1 autophagy down Homo sapiens prediction 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 hsa-miR-106a predicted by miR-106b (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 3491 hsa-miR-30b miR-30abcdef/30abe-5p/384-5p MIMAT0000420 miRNA BECN1 autophagy down Homo sapiens prediction 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related hsa-miR-30b predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and BECN1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 3492 hsa-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0001413 miRNA ATG5 autophagy down Homo sapiens prediction 9606 9474 APG5|APG5-LIKE|APG5L|ASP|hAPG5 HGNC:589|MIM:604261|Ensembl:ENSG00000057663|HPRD:16051|Vega:OTTHUMG00000016193 6 6q21 autophagy related 5 protein-coding autophagy related 5 hsa-miR-20b predicted by miR-20a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (25485521) 3493 hsa-let-7a let-7/98/4458/4500 MIMAT0000062 miRNA ATG4B autophagy down Homo sapiens prediction 9606 23192 APG4B|AUTL1 HGNC:20790|MIM:611338|Ensembl:ENSG00000168397|HPRD:16499|Vega:OTTHUMG00000151514 2 2q37.3 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase hsa-let-7a predicted by let-7b (Homo sapiens), and ATG4B predicted by ATG4B (Homo sapiens) according to Pubmed ID (22135297) 3494 hsa-miR-302a miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0000684 miRNA FYCO1 autophagy down Homo sapiens prediction 9606 79443 CATC2|CTRCT18|RUFY3|ZFYVE7 HGNC:14673|MIM:607182|Ensembl:ENSG00000163820|HPRD:06215|Vega:OTTHUMG00000133447 3 3p21.31 FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 hsa-miR-302a predicted by miR-373 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3495 hsa-miR-29a miR-29abcd MIMAT0000086 miRNA PSME4 autophagy down Homo sapiens prediction 9606 23198 PA200 HGNC:20635|MIM:607705|Ensembl:ENSG00000068878|HPRD:09652|Vega:OTTHUMG00000151852 2 2p16.2 proteasome (prosome, macropain) activator subunit 4 protein-coding proteasome (prosome, macropain) activator subunit 4 hsa-miR-29a predicted by miR-29b (Homo sapiens), and PSME4 predicted by PSME4 (Homo sapiens) according to Pubmed ID (25234165) 3496 hsa-miR-30c miR-30abcdef/30abe-5p/384-5p MIMAT0000244 miRNA ATG5 autophagy down Homo sapiens prediction 9606 9474 APG5|APG5-LIKE|APG5L|ASP|hAPG5 HGNC:589|MIM:604261|Ensembl:ENSG00000057663|HPRD:16051|Vega:OTTHUMG00000016193 6 6q21 autophagy related 5 protein-coding autophagy related 5 hsa-miR-30c predicted by miR-30a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22395361),(22617440),(22902544),(23274497),(24148619) 3497 hsa-miR-4295 miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0016844 miRNA ATG2B autophagy down Homo sapiens prediction 9606 55102 C14orf103 HGNC:20187|Ensembl:ENSG00000066739|HPRD:12626|Vega:OTTHUMG00000149933 14 14q32.2 autophagy related 2B protein-coding autophagy related 2B hsa-miR-4295 predicted by miR-130a (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (22902544) 3498 hsa-miR-4735-3p miR-18ab/4735-3p MIMAT0019861 miRNA ATM autophagy down Homo sapiens prediction 9606 472 AT1|ATA|ATC|ATD|ATDC|ATE|TEL1|TELO1 HGNC:795|MIM:607585|Ensembl:ENSG00000149311|HPRD:06347|Vega:OTTHUMG00000166480 11 11q22-q23 ATM serine/threonine kinase protein-coding ATM serine/threonine kinase hsa-miR-4735-3p predicted by miR-18a (Homo sapiens), and ATM predicted by ATM (Homo sapiens) according to Pubmed ID (23229340) 3499 hsa-miR-424 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0001341 miRNA BCL2L2 autophagy down Homo sapiens prediction 9606 599 BCL-W|BCL2-L-2|BCLW|PPP1R51 HGNC:995|MIM:601931|Ensembl:ENSG00000129473|HPRD:03569|Vega:OTTHUMG00000028738 14 14q11.2-q12 BCL2-like 2 protein-coding BCL2-like 2 hsa-miR-424 predicted by miR-15b (Mus musculus), and BCL2L2 predicted by Bcl2l2 (Mus musculus) according to Pubmed ID (21770019) 3500 hsa-miR-520b miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0002843 miRNA FYCO1 autophagy down Homo sapiens prediction 9606 79443 CATC2|CTRCT18|RUFY3|ZFYVE7 HGNC:14673|MIM:607182|Ensembl:ENSG00000163820|HPRD:06215|Vega:OTTHUMG00000133447 3 3p21.31 FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 hsa-miR-520b predicted by miR-373 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3501 hsa-miR-30a miR-30abcdef/30abe-5p/384-5p MIMAT0000087 miRNA ATG2B autophagy down Homo sapiens prediction 9606 55102 C14orf103 HGNC:20187|Ensembl:ENSG00000066739|HPRD:12626|Vega:OTTHUMG00000149933 14 14q32.2 autophagy related 2B protein-coding autophagy related 2B hsa-miR-30a predicted by mir-30d (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (23274497) 3502 hsa-miR-363 miR-25/32/92abc/363/363-3p/367 MIMAT0000707 miRNA ULK1 autophagy down Homo sapiens prediction 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 hsa-miR-363 predicted by miR-25 (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (25026296) 3503 hsa-let-7e let-7/98/4458/4500 MIMAT0000066 miRNA IGF1R autophagy down Homo sapiens prediction 9606 3480 CD221|IGFIR|IGFR|JTK13 HGNC:5465|MIM:147370|Ensembl:ENSG00000140443|HPRD:00932|Vega:OTTHUMG00000149851 15 15q26.3 insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor hsa-let-7e predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 3504 hsa-miR-15b miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000417 miRNA ATG7 autophagy down Homo sapiens prediction 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 hsa-miR-15b predicted by miR-16 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23143396) 3505 hsa-miR-15b miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000417 miRNA BAG5 autophagy down Homo sapiens prediction 9606 9529 BAG-5 HGNC:941|MIM:603885|Ensembl:ENSG00000166170|HPRD:04862|Vega:OTTHUMG00000171763 14 14q32.33 BCL2-associated athanogene 5 protein-coding BCL2-associated athanogene 5 hsa-miR-15b predicted by miR-16 (Mus musculus), and BAG5 predicted by Bag5 (Mus musculus) according to Pubmed ID (21770019) 3506 hsa-miR-3666 miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0018088 miRNA RB1CC1 autophagy down Homo sapiens prediction 9606 9821 ATG17|CC1|FIP200|PPP1R131 HGNC:15574|MIM:606837|Ensembl:ENSG00000023287|HPRD:06019|Vega:OTTHUMG00000164268 8 8q11 RB1-inducible coiled-coil 1 protein-coding RB1-inducible coiled-coil 1 hsa-miR-3666 predicted by miR-133b (Homo sapiens), and RB1CC1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 3507 hsa-miR-372 miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0000724 miRNA FYCO1 autophagy down Homo sapiens prediction 9606 79443 CATC2|CTRCT18|RUFY3|ZFYVE7 HGNC:14673|MIM:607182|Ensembl:ENSG00000163820|HPRD:06215|Vega:OTTHUMG00000133447 3 3p21.31 FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 hsa-miR-372 predicted by miR-373 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3508 hsa-miR-181d miR-181abcd/4262 MIMAT0002821 miRNA ATG10 autophagy down Homo sapiens prediction 9606 83734 APG10|APG10L|pp12616 HGNC:20315|MIM:610800|Ensembl:ENSG00000152348|HPRD:16497|Vega:OTTHUMG00000119041 5 5q14.1 autophagy related 10 protein-coding autophagy related 10 hsa-miR-181d predicted by miR-181a (Homo sapiens), and ATG10 predicted by ATG10 (Homo sapiens) according to Pubmed ID (22356768) 3509 hsa-miR-92b miR-25/32/92abc/363/363-3p/367 MIMAT0003218 miRNA ULK1 autophagy down Homo sapiens prediction 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 hsa-miR-92b predicted by miR-25 (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (25026296) 3510 hsa-miR-99b miR-99ab/100 MIMAT0000689 miRNA IGF1R autophagy down Homo sapiens prediction 9606 3480 CD221|IGFIR|IGFR|JTK13 HGNC:5465|MIM:147370|Ensembl:ENSG00000140443|HPRD:00932|Vega:OTTHUMG00000149851 15 15q26.3 insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor hsa-miR-99b predicted by miR-100 (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25026290) 3511 hsa-miR-30e miR-30abcdef/30abe-5p/384-5p MIMAT0000692 miRNA ATG12 autophagy down Homo sapiens prediction 9606 9140 APG12|APG12L|FBR93|HAPG12 HGNC:588|MIM:609608|Ensembl:ENSG00000145782|HPRD:08496|Vega:OTTHUMG00000128889 5 5q21-q22 autophagy related 12 protein-coding autophagy related 12 hsa-miR-30e predicted by miR-30b (Homo sapiens), and ATG12 predicted by ATG12 (Homo sapiens) according to Pubmed ID (22647547),(23274497) 3512 hsa-miR-15a miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000068 miRNA BCL2L2 autophagy down Homo sapiens prediction 9606 599 BCL-W|BCL2-L-2|BCLW|PPP1R51 HGNC:995|MIM:601931|Ensembl:ENSG00000129473|HPRD:03569|Vega:OTTHUMG00000028738 14 14q11.2-q12 BCL2-like 2 protein-coding BCL2-like 2 hsa-miR-15a predicted by miR-15b (Mus musculus), and BCL2L2 predicted by Bcl2l2 (Mus musculus) according to Pubmed ID (21770019) 3513 hsa-miR-15a miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000068 miRNA BAG5 autophagy down Homo sapiens prediction 9606 9529 BAG-5 HGNC:941|MIM:603885|Ensembl:ENSG00000166170|HPRD:04862|Vega:OTTHUMG00000171763 14 14q32.33 BCL2-associated athanogene 5 protein-coding BCL2-associated athanogene 5 hsa-miR-15a predicted by miR-16 (Mus musculus), and BAG5 predicted by Bag5 (Mus musculus) according to Pubmed ID (21770019) 3514 hsa-miR-520c-3p miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0002846 miRNA ATG7 autophagy down Homo sapiens prediction 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 hsa-miR-520c-3p predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 3515 hsa-miR-302a miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0000684 miRNA ATG7 autophagy down Homo sapiens prediction 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 hsa-miR-302a predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 3516 hsa-miR-32 miR-25/32/92abc/363/363-3p/367 MIMAT0000090 miRNA ULK1 autophagy down Homo sapiens prediction 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 hsa-miR-32 predicted by miR-25 (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (25026296) 3517 hsa-miR-93 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000093 miRNA ATG7 autophagy down Homo sapiens prediction 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 hsa-miR-93 predicted by miR-17 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 3518 hsa-let-7a let-7/98/4458/4500 MIMAT0000062 miRNA OLR1 autophagy down Homo sapiens prediction 9606 4973 CLEC8A|LOX1|LOXIN|SCARE1|SLOX1 HGNC:8133|MIM:602601|Ensembl:ENSG00000173391|HPRD:04003|Vega:OTTHUMG00000168527 12 12p13.2-p12.3 oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding oxidized low density lipoprotein (lectin-like) receptor 1 hsa-let-7a predicted by let-7g (Mus musculus), and OLR1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 3519 hsa-miR-429 miR-200bc/429/548a MIMAT0001536 miRNA HMOX1 autophagy down Homo sapiens prediction 9606 3162 HMOX1D|HO-1|HSP32|bK286B10 HGNC:5013|MIM:141250|Ensembl:ENSG00000100292|HPRD:00782|Vega:OTTHUMG00000150960 22 22q13.1 heme oxygenase (decycling) 1 protein-coding heme oxygenase (decycling) 1 hsa-miR-429 predicted by miR-200c (Homo sapiens), and HMOX1 predicted by HMOX1 (Homo sapiens) according to Pubmed ID (25150313) 3520 hsa-miR-302e miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0005931 miRNA SQSTM1 autophagy down Homo sapiens prediction 9606 8878 A170|OSIL|PDB3|ZIP3|p60|p62|p62B HGNC:11280|MIM:601530|Ensembl:ENSG00000161011|HPRD:03319|Vega:OTTHUMG00000150643 5 5q35 sequestosome 1 protein-coding sequestosome 1 hsa-miR-302e predicted by miR-372 (Homo sapiens), and SQSTM1 predicted by SQSTM1 (Homo sapiens) according to Pubmed ID (24991827) 3521 hsa-miR-424 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0001341 miRNA ATG7 autophagy down Homo sapiens prediction 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 hsa-miR-424 predicted by miR-16 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23143396) 3522 hsa-miR-520d-3p miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0002856 miRNA SQSTM1 autophagy down Homo sapiens prediction 9606 8878 A170|OSIL|PDB3|ZIP3|p60|p62|p62B HGNC:11280|MIM:601530|Ensembl:ENSG00000161011|HPRD:03319|Vega:OTTHUMG00000150643 5 5q35 sequestosome 1 protein-coding sequestosome 1 hsa-miR-520d-3p predicted by miR-372 (Homo sapiens), and SQSTM1 predicted by SQSTM1 (Homo sapiens) according to Pubmed ID (24991827) 3523 hsa-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000680 miRNA ATG5 autophagy down Homo sapiens prediction 9606 9474 APG5|APG5-LIKE|APG5L|ASP|hAPG5 HGNC:589|MIM:604261|Ensembl:ENSG00000057663|HPRD:16051|Vega:OTTHUMG00000016193 6 6q21 autophagy related 5 protein-coding autophagy related 5 hsa-miR-106b predicted by miR-20a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (25485521) 3524 hsa-miR-30c miR-30abcdef/30abe-5p/384-5p MIMAT0000244 miRNA BNIP3L autophagy down Homo sapiens prediction 9606 665 BNIP3a|NIX HGNC:1085|MIM:605368|Ensembl:ENSG00000104765|HPRD:07288|Vega:OTTHUMG00000099433 8 8p21 BCL2/adenovirus E1B 19kDa interacting protein 3-like protein-coding BCL2/adenovirus E1B 19kDa interacting protein 3-like hsa-miR-30c predicted by miR-30d (Homo sapiens), and BNIP3L predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 3525 hsa-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0001413 miRNA ATG7 autophagy down Homo sapiens prediction 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 hsa-miR-20b predicted by miR-17 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 3526 hsa-miR-199b-5p miR-199ab-5p MIMAT0000263 miRNA DRAM1 autophagy down Homo sapiens prediction 9606 55332 DRAM HGNC:25645|MIM:610776|Ensembl:ENSG00000136048|HPRD:07743|Vega:OTTHUMG00000170447 12 12q23.2 DNA-damage regulated autophagy modulator 1 protein-coding DNA-damage regulated autophagy modulator 1 hsa-miR-199b-5p predicted by miR-199a-5p (Homo sapiens), and DRAM1 predicted by DRAM1 (Homo sapiens) according to Pubmed ID (23337876) 3527 hsa-let-7g let-7/98/4458/4500 MIMAT0000414 miRNA ATG4B autophagy down Homo sapiens prediction 9606 23192 APG4B|AUTL1 HGNC:20790|MIM:611338|Ensembl:ENSG00000168397|HPRD:16499|Vega:OTTHUMG00000151514 2 2q37.3 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase hsa-let-7g predicted by let-7b (Homo sapiens), and ATG4B predicted by ATG4B (Homo sapiens) according to Pubmed ID (22135297) 3528 hsa-let-7b let-7/98/4458/4500 MIMAT0000063 miRNA IGF1R autophagy down Homo sapiens prediction 9606 3480 CD221|IGFIR|IGFR|JTK13 HGNC:5465|MIM:147370|Ensembl:ENSG00000140443|HPRD:00932|Vega:OTTHUMG00000149851 15 15q26.3 insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor hsa-let-7b predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 3529 hsa-miR-302d miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0000718 miRNA ULK1 autophagy down Homo sapiens prediction 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 hsa-miR-302d predicted by miR-291 (Mus musculus), and ULK1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 3530 hsa-miR-374b miR-374ab MIMAT0004955 miRNA TP63 autophagy down Homo sapiens prediction 9606 8626 AIS|B(p51A)|B(p51B)|EEC3|KET|LMS|NBP|OFC8|RHS|SHFM4|TP53CP|TP53L|TP73L|p40|p51|p53CP|p63|p73H|p73L HGNC:15979|MIM:603273|Ensembl:ENSG00000073282|HPRD:04469|Vega:OTTHUMG00000156313 3 3q28 tumor protein p63 protein-coding tumor protein p63 hsa-miR-374b predicted by miR-374a (Homo sapiens), and TP63 predicted by TP63 (Homo sapiens) according to Pubmed ID (22356768) 3531 hsa-miR-181c miR-181abcd/4262 MIMAT0000258 miRNA TP63 autophagy down Homo sapiens prediction 9606 8626 AIS|B(p51A)|B(p51B)|EEC3|KET|LMS|NBP|OFC8|RHS|SHFM4|TP53CP|TP53L|TP73L|p40|p51|p53CP|p63|p73H|p73L HGNC:15979|MIM:603273|Ensembl:ENSG00000073282|HPRD:04469|Vega:OTTHUMG00000156313 3 3q28 tumor protein p63 protein-coding tumor protein p63 hsa-miR-181c predicted by miR-181a (Homo sapiens), and TP63 predicted by TP63 (Homo sapiens) according to Pubmed ID (22356768) 3532 hsa-miR-449a miR-34ac/34bc-5p/449abc/449c-5p MIMAT0001541 miRNA ATG9A autophagy down Homo sapiens prediction 9606 79065 APG9L1|MGD3208|mATG9 HGNC:22408|MIM:612204|Ensembl:ENSG00000198925|HPRD:07979|Vega:OTTHUMG00000154557 2 2q35 autophagy related 9A protein-coding autophagy related 9A hsa-miR-449a predicted by miR-34a (Homo sapiens),miR-34a (Rattus norvegicus), and ATG9A predicted by Atg9a (Rattus norvegicus),ATG9A (Homo sapiens) according to Pubmed ID (22902544),(24728149),(24973144) 3533 hsa-miR-1271 miR-96/507/1271 MIMAT0005796 miRNA ATG7 autophagy down Homo sapiens prediction 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 hsa-miR-1271 predicted by miR-96 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (25333253) 3534 hsa-miR-301a miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0000688 miRNA RB1CC1 autophagy down Homo sapiens prediction 9606 9821 ATG17|CC1|FIP200|PPP1R131 HGNC:15574|MIM:606837|Ensembl:ENSG00000023287|HPRD:06019|Vega:OTTHUMG00000164268 8 8q11 RB1-inducible coiled-coil 1 protein-coding RB1-inducible coiled-coil 1 hsa-miR-301a predicted by miR-133b (Homo sapiens), and RB1CC1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 3535 hsa-miR-1271 miR-96/507/1271 MIMAT0005796 miRNA MTOR autophagy down Homo sapiens prediction 9606 2475 FRAP|FRAP1|FRAP2|RAFT1|RAPT1 HGNC:3942|MIM:601231|Ensembl:ENSG00000198793|HPRD:03134|Vega:OTTHUMG00000002001 1 1p36.2 mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) hsa-miR-1271 predicted by miR-96 (Homo sapiens), and MTOR predicted by MTOR (Homo sapiens) according to Pubmed ID (25333253) 3536 hsa-miR-211 miR-204/204b/211 MIMAT0000268 miRNA TRPM3 autophagy down Homo sapiens prediction 9606 80036 GON-2|LTRPC3|MLSN2 HGNC:17992|MIM:608961|Ensembl:ENSG00000083067|HPRD:10605|Vega:OTTHUMG00000019997 9 9q21.12 transient receptor potential cation channel, subfamily M, member 3 protein-coding transient receptor potential cation channel, subfamily M, member 3 hsa-miR-211 predicted by miR-204 (Homo sapiens), and TRPM3 predicted by TRPM3 (Homo sapiens) according to Pubmed ID (25517751) 3537 hsa-miR-195 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000461 miRNA BAG5 autophagy down Homo sapiens prediction 9606 9529 BAG-5 HGNC:941|MIM:603885|Ensembl:ENSG00000166170|HPRD:04862|Vega:OTTHUMG00000171763 14 14q32.33 BCL2-associated athanogene 5 protein-coding BCL2-associated athanogene 5 hsa-miR-195 predicted by miR-16 (Mus musculus), and BAG5 predicted by Bag5 (Mus musculus) according to Pubmed ID (21770019) 3538 hsa-miR-15b miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000417 miRNA BCL2L2 autophagy down Homo sapiens prediction 9606 599 BCL-W|BCL2-L-2|BCLW|PPP1R51 HGNC:995|MIM:601931|Ensembl:ENSG00000129473|HPRD:03569|Vega:OTTHUMG00000028738 14 14q11.2-q12 BCL2-like 2 protein-coding BCL2-like 2 hsa-miR-15b predicted by miR-15b (Mus musculus), and BCL2L2 predicted by Bcl2l2 (Mus musculus) according to Pubmed ID (21770019) 3539 hsa-miR-520a-3p miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0002834 miRNA FYCO1 autophagy down Homo sapiens prediction 9606 79443 CATC2|CTRCT18|RUFY3|ZFYVE7 HGNC:14673|MIM:607182|Ensembl:ENSG00000163820|HPRD:06215|Vega:OTTHUMG00000133447 3 3p21.31 FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 hsa-miR-520a-3p predicted by miR-373 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3540 hsa-miR-30c miR-30abcdef/30abe-5p/384-5p MIMAT0000244 miRNA MAP1LC3B autophagy down Homo sapiens prediction 9606 81631 ATG8F|LC3B|MAP1A/1BLC3|MAP1LC3B-a HGNC:13352|MIM:609604|Ensembl:ENSG00000140941|HPRD:14358|Vega:OTTHUMG00000137654 16 16q24.2 microtubule-associated protein 1 light chain 3 beta protein-coding microtubule-associated protein 1 light chain 3 beta hsa-miR-30c predicted by miR-30a (Homo sapiens), and MAP1LC3B predicted by MAP1LC3B (Homo sapiens) according to Pubmed ID (22135297) 3541 hsa-miR-93 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000093 miRNA ULK1 autophagy down Homo sapiens prediction 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 hsa-miR-93 predicted by miR-106b (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 3542 hsa-miR-320d miR-320abcd/4429 MIMAT0006764 miRNA ULK1 autophagy down Homo sapiens prediction 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 hsa-miR-320d predicted by miR-320a (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (23622248) 3543 hsa-miR-30d miR-30abcdef/30abe-5p/384-5p MIMAT0000245 miRNA MAP1LC3B autophagy down Homo sapiens prediction 9606 81631 ATG8F|LC3B|MAP1A/1BLC3|MAP1LC3B-a HGNC:13352|MIM:609604|Ensembl:ENSG00000140941|HPRD:14358|Vega:OTTHUMG00000137654 16 16q24.2 microtubule-associated protein 1 light chain 3 beta protein-coding microtubule-associated protein 1 light chain 3 beta hsa-miR-30d predicted by miR-30a (Homo sapiens), and MAP1LC3B predicted by MAP1LC3B (Homo sapiens) according to Pubmed ID (22135297) 3544 hsa-let-7i let-7/98/4458/4500 MIMAT0000415 miRNA OLR1 autophagy down Homo sapiens prediction 9606 4973 CLEC8A|LOX1|LOXIN|SCARE1|SLOX1 HGNC:8133|MIM:602601|Ensembl:ENSG00000173391|HPRD:04003|Vega:OTTHUMG00000168527 12 12p13.2-p12.3 oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding oxidized low density lipoprotein (lectin-like) receptor 1 hsa-let-7i predicted by let-7g (Mus musculus), and OLR1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 3545 hsa-miR-130b miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0000691 miRNA RB1CC1 autophagy down Homo sapiens prediction 9606 9821 ATG17|CC1|FIP200|PPP1R131 HGNC:15574|MIM:606837|Ensembl:ENSG00000023287|HPRD:06019|Vega:OTTHUMG00000164268 8 8q11 RB1-inducible coiled-coil 1 protein-coding RB1-inducible coiled-coil 1 hsa-miR-130b predicted by miR-133b (Homo sapiens), and RB1CC1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 3546 hsa-miR-4262 miR-181abcd/4262 MIMAT0016894 miRNA TP63 autophagy down Homo sapiens prediction 9606 8626 AIS|B(p51A)|B(p51B)|EEC3|KET|LMS|NBP|OFC8|RHS|SHFM4|TP53CP|TP53L|TP73L|p40|p51|p53CP|p63|p73H|p73L HGNC:15979|MIM:603273|Ensembl:ENSG00000073282|HPRD:04469|Vega:OTTHUMG00000156313 3 3q28 tumor protein p63 protein-coding tumor protein p63 hsa-miR-4262 predicted by miR-181a (Homo sapiens), and TP63 predicted by TP63 (Homo sapiens) according to Pubmed ID (22356768) 3547 hsa-miR-302c miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0000717 miRNA FYCO1 autophagy down Homo sapiens prediction 9606 79443 CATC2|CTRCT18|RUFY3|ZFYVE7 HGNC:14673|MIM:607182|Ensembl:ENSG00000163820|HPRD:06215|Vega:OTTHUMG00000133447 3 3p21.31 FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 hsa-miR-302c predicted by miR-373 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3548 hsa-miR-18b miR-18ab/4735-3p MIMAT0001412 miRNA ATM autophagy down Homo sapiens prediction 9606 472 AT1|ATA|ATC|ATD|ATDC|ATE|TEL1|TELO1 HGNC:795|MIM:607585|Ensembl:ENSG00000149311|HPRD:06347|Vega:OTTHUMG00000166480 11 11q22-q23 ATM serine/threonine kinase protein-coding ATM serine/threonine kinase hsa-miR-18b predicted by miR-18a (Homo sapiens), and ATM predicted by ATM (Homo sapiens) according to Pubmed ID (23229340) 3549 hsa-miR-130a miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0000425 miRNA FYCO1 autophagy down Homo sapiens prediction 9606 79443 CATC2|CTRCT18|RUFY3|ZFYVE7 HGNC:14673|MIM:607182|Ensembl:ENSG00000163820|HPRD:06215|Vega:OTTHUMG00000133447 3 3p21.31 FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 hsa-miR-130a predicted by miR-130b (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3550 hsa-miR-199b-5p miR-199ab-5p MIMAT0000263 miRNA HSPA5 autophagy down Homo sapiens prediction 9606 3309 BIP|GRP78|HEL-S-89n|MIF2 HGNC:5238|MIM:138120|Ensembl:ENSG00000044574|HPRD:00682|Vega:OTTHUMG00000020672 9 9q33.3 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) protein-coding heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) hsa-miR-199b-5p predicted by miR-199a-5p (Mus musculus), and HSPA5 predicted by Hspa5 (Mus musculus) according to Pubmed ID (23598416) 3551 hsa-miR-519d miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002853 miRNA SQSTM1 autophagy down Homo sapiens prediction 9606 8878 A170|OSIL|PDB3|ZIP3|p60|p62|p62B HGNC:11280|MIM:601530|Ensembl:ENSG00000161011|HPRD:03319|Vega:OTTHUMG00000150643 5 5q35 sequestosome 1 protein-coding sequestosome 1 hsa-miR-519d predicted by miR-106b (Homo sapiens),miR-106 (Mus musculus), and SQSTM1 predicted by Sqstm1 (Mus musculus),SQSTM1 (Homo sapiens) according to Pubmed ID (21628417),(22441107),(25485521),(25617127) 3552 hsa-miR-181c miR-181abcd/4262 MIMAT0000258 miRNA ATG10 autophagy down Homo sapiens prediction 9606 83734 APG10|APG10L|pp12616 HGNC:20315|MIM:610800|Ensembl:ENSG00000152348|HPRD:16497|Vega:OTTHUMG00000119041 5 5q14.1 autophagy related 10 protein-coding autophagy related 10 hsa-miR-181c predicted by miR-181a (Homo sapiens), and ATG10 predicted by ATG10 (Homo sapiens) according to Pubmed ID (22356768) 3553 hsa-miR-4262 miR-181abcd/4262 MIMAT0016894 miRNA ATG5 autophagy down Homo sapiens prediction 9606 9474 APG5|APG5-LIKE|APG5L|ASP|hAPG5 HGNC:589|MIM:604261|Ensembl:ENSG00000057663|HPRD:16051|Vega:OTTHUMG00000016193 6 6q21 autophagy related 5 protein-coding autophagy related 5 hsa-miR-4262 predicted by miR-181a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22356768),(22902544),(23322078) 3554 hsa-miR-181b miR-181abcd/4262 MIMAT0000257 miRNA TP63 autophagy down Homo sapiens prediction 9606 8626 AIS|B(p51A)|B(p51B)|EEC3|KET|LMS|NBP|OFC8|RHS|SHFM4|TP53CP|TP53L|TP73L|p40|p51|p53CP|p63|p73H|p73L HGNC:15979|MIM:603273|Ensembl:ENSG00000073282|HPRD:04469|Vega:OTTHUMG00000156313 3 3q28 tumor protein p63 protein-coding tumor protein p63 hsa-miR-181b predicted by miR-181a (Homo sapiens), and TP63 predicted by TP63 (Homo sapiens) according to Pubmed ID (22356768) 3555 hsa-let-7a let-7/98/4458/4500 MIMAT0000062 miRNA IGF1R autophagy down Homo sapiens prediction 9606 3480 CD221|IGFIR|IGFR|JTK13 HGNC:5465|MIM:147370|Ensembl:ENSG00000140443|HPRD:00932|Vega:OTTHUMG00000149851 15 15q26.3 insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor hsa-let-7a predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 3556 hsa-miR-4458 let-7/98/4458/4500 MIMAT0018980 miRNA OLR1 autophagy down Homo sapiens prediction 9606 4973 CLEC8A|LOX1|LOXIN|SCARE1|SLOX1 HGNC:8133|MIM:602601|Ensembl:ENSG00000173391|HPRD:04003|Vega:OTTHUMG00000168527 12 12p13.2-p12.3 oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding oxidized low density lipoprotein (lectin-like) receptor 1 hsa-miR-4458 predicted by let-7g (Mus musculus), and OLR1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 3557 hsa-miR-301b miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0004958 miRNA FYCO1 autophagy down Homo sapiens prediction 9606 79443 CATC2|CTRCT18|RUFY3|ZFYVE7 HGNC:14673|MIM:607182|Ensembl:ENSG00000163820|HPRD:06215|Vega:OTTHUMG00000133447 3 3p21.31 FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 hsa-miR-301b predicted by miR-130b (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3558 hsa-miR-520b miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0002843 miRNA ULK1 autophagy down Homo sapiens prediction 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 hsa-miR-520b predicted by miR-291 (Mus musculus), and ULK1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 3559 hsa-miR-301a miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0000688 miRNA ATG2B autophagy down Homo sapiens prediction 9606 55102 C14orf103 HGNC:20187|Ensembl:ENSG00000066739|HPRD:12626|Vega:OTTHUMG00000149933 14 14q32.2 autophagy related 2B protein-coding autophagy related 2B hsa-miR-301a predicted by miR-130a (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (22902544) 3560 hsa-let-7c let-7/98/4458/4500 MIMAT0000064 miRNA IGF1R autophagy down Homo sapiens prediction 9606 3480 CD221|IGFIR|IGFR|JTK13 HGNC:5465|MIM:147370|Ensembl:ENSG00000140443|HPRD:00932|Vega:OTTHUMG00000149851 15 15q26.3 insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor hsa-let-7c predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 3561 hsa-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000680 miRNA HIF1A autophagy down Homo sapiens prediction 9606 3091 HIF-1A|HIF-1alpha|HIF1|HIF1-ALPHA|MOP1|PASD8|bHLHe78 HGNC:4910|MIM:603348|Ensembl:ENSG00000100644|HPRD:04517|Vega:OTTHUMG00000140344 14 14q23.2 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) hsa-miR-106b predicted by miR-20a (Homo sapiens), and HIF1A predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 3562 hsa-miR-29b miR-29abcd MIMAT0000100 miRNA ATG9A autophagy down Homo sapiens prediction 9606 79065 APG9L1|MGD3208|mATG9 HGNC:22408|MIM:612204|Ensembl:ENSG00000198925|HPRD:07979|Vega:OTTHUMG00000154557 2 2q35 autophagy related 9A protein-coding autophagy related 9A hsa-miR-29b predicted by miR-29b (Bos taurus), and ATG9A predicted by ATG9A (Bos taurus) according to Pubmed ID (25234643) 3563 hsa-miR-34c-5p miR-34ac/34bc-5p/449abc/449c-5p MIMAT0000686 miRNA ATG9A autophagy down Homo sapiens prediction 9606 79065 APG9L1|MGD3208|mATG9 HGNC:22408|MIM:612204|Ensembl:ENSG00000198925|HPRD:07979|Vega:OTTHUMG00000154557 2 2q35 autophagy related 9A protein-coding autophagy related 9A hsa-miR-34c-5p predicted by miR-34a (Homo sapiens),miR-34a (Rattus norvegicus), and ATG9A predicted by Atg9a (Rattus norvegicus),ATG9A (Homo sapiens) according to Pubmed ID (22902544),(24728149),(24973144) 3564 hsa-miR-211 miR-204/204b/211 MIMAT0000268 miRNA VHL autophagy down Homo sapiens prediction 9606 7428 HRCA1|RCA1|VHL1|pVHL HGNC:12687|MIM:608537|HPRD:01905 3 3p25.3 von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase protein-coding von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase hsa-miR-211 predicted by miR-204 (Homo sapiens), and VHL predicted by VHL (Homo sapiens) according to Pubmed ID (25517751) 3565 hsa-miR-92b miR-25/32/92abc/363/363-3p/367 MIMAT0003218 miRNA UVRAG autophagy down Homo sapiens prediction 9606 7405 DHTX|VPS38|p63 HGNC:12640|MIM:602493|HPRD:03929 11 11q13.5 UV radiation resistance associated protein-coding UV radiation resistance associated hsa-miR-92b predicted by miR-32 (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22135297) 3566 hsa-miR-520b miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0002843 miRNA ATG7 autophagy down Homo sapiens prediction 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 hsa-miR-520b predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 3567 hsa-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000075 miRNA SQSTM1 autophagy down Homo sapiens prediction 9606 8878 A170|OSIL|PDB3|ZIP3|p60|p62|p62B HGNC:11280|MIM:601530|Ensembl:ENSG00000161011|HPRD:03319|Vega:OTTHUMG00000150643 5 5q35 sequestosome 1 protein-coding sequestosome 1 hsa-miR-20a predicted by miR-106b (Homo sapiens),miR-106 (Mus musculus), and SQSTM1 predicted by Sqstm1 (Mus musculus),SQSTM1 (Homo sapiens) according to Pubmed ID (21628417),(22441107),(25485521),(25617127) 3568 hsa-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0001413 miRNA FYCO1 autophagy down Homo sapiens prediction 9606 79443 CATC2|CTRCT18|RUFY3|ZFYVE7 HGNC:14673|MIM:607182|Ensembl:ENSG00000163820|HPRD:06215|Vega:OTTHUMG00000133447 3 3p21.31 FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 hsa-miR-20b predicted by miR-93 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3569 hsa-miR-520d-3p miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0002856 miRNA ATG7 autophagy down Homo sapiens prediction 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 hsa-miR-520d-3p predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 3570 hsa-miR-30d miR-30abcdef/30abe-5p/384-5p MIMAT0000245 miRNA ATG2B autophagy down Homo sapiens prediction 9606 55102 C14orf103 HGNC:20187|Ensembl:ENSG00000066739|HPRD:12626|Vega:OTTHUMG00000149933 14 14q32.2 autophagy related 2B protein-coding autophagy related 2B hsa-miR-30d predicted by mir-30d (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (23274497) 3571 hsa-miR-424 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0001341 miRNA ATG14 autophagy down Homo sapiens prediction 9606 22863 ATG14L|BARKOR|KIAA0831 HGNC:19962|MIM:613515|Ensembl:ENSG00000126775|HPRD:13820|Vega:OTTHUMG00000172129 14 14q22.3 autophagy related 14 protein-coding autophagy related 14 hsa-miR-424 predicted by miR-195 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 3572 hsa-miR-520c-3p miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0002846 miRNA FYCO1 autophagy down Homo sapiens prediction 9606 79443 CATC2|CTRCT18|RUFY3|ZFYVE7 HGNC:14673|MIM:607182|Ensembl:ENSG00000163820|HPRD:06215|Vega:OTTHUMG00000133447 3 3p21.31 FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 hsa-miR-520c-3p predicted by miR-373 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3573 hsa-let-7f let-7/98/4458/4500 MIMAT0000067 miRNA OLR1 autophagy down Homo sapiens prediction 9606 4973 CLEC8A|LOX1|LOXIN|SCARE1|SLOX1 HGNC:8133|MIM:602601|Ensembl:ENSG00000173391|HPRD:04003|Vega:OTTHUMG00000168527 12 12p13.2-p12.3 oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding oxidized low density lipoprotein (lectin-like) receptor 1 hsa-let-7f predicted by let-7g (Mus musculus), and OLR1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 3574 hsa-miR-212 miR-132/212/212-3p MIMAT0000269 miRNA FOXO3 autophagy down Homo sapiens prediction 9606 2309 AF6q21|FKHRL1|FKHRL1P2|FOXO2|FOXO3A HGNC:3821|MIM:602681|Ensembl:ENSG00000118689|HPRD:04061|Vega:OTTHUMG00000015327 6 6q21 forkhead box O3 protein-coding forkhead box O3 hsa-miR-212 predicted by miR-132 (Mus musculus), and FOXO3 predicted by Foxo3 (Mus musculus) according to Pubmed ID (23011132) 3575 hsa-miR-302e miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0005931 miRNA FYCO1 autophagy down Homo sapiens prediction 9606 79443 CATC2|CTRCT18|RUFY3|ZFYVE7 HGNC:14673|MIM:607182|Ensembl:ENSG00000163820|HPRD:06215|Vega:OTTHUMG00000133447 3 3p21.31 FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 hsa-miR-302e predicted by miR-373 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3576 hsa-miR-520d-3p miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0002856 miRNA FYCO1 autophagy down Homo sapiens prediction 9606 79443 CATC2|CTRCT18|RUFY3|ZFYVE7 HGNC:14673|MIM:607182|Ensembl:ENSG00000163820|HPRD:06215|Vega:OTTHUMG00000133447 3 3p21.31 FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 hsa-miR-520d-3p predicted by miR-373 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3577 hsa-miR-520a-3p miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0002834 miRNA ATG7 autophagy down Homo sapiens prediction 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 hsa-miR-520a-3p predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 3578 hsa-miR-302a miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0000684 miRNA ULK1 autophagy down Homo sapiens prediction 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 hsa-miR-302a predicted by miR-291 (Mus musculus), and ULK1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 3579 hsa-miR-4500 let-7/98/4458/4500 MIMAT0019036 miRNA ATG4B autophagy down Homo sapiens prediction 9606 23192 APG4B|AUTL1 HGNC:20790|MIM:611338|Ensembl:ENSG00000168397|HPRD:16499|Vega:OTTHUMG00000151514 2 2q37.3 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase hsa-miR-4500 predicted by let-7b (Homo sapiens), and ATG4B predicted by ATG4B (Homo sapiens) according to Pubmed ID (22135297) 3580 hsa-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0001413 miRNA ULK1 autophagy down Homo sapiens prediction 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 hsa-miR-20b predicted by miR-106b (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 3581 hsa-miR-302e miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0005931 miRNA ULK1 autophagy down Homo sapiens prediction 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 hsa-miR-302e predicted by miR-291 (Mus musculus), and ULK1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 3582 hsa-miR-29b miR-29abcd MIMAT0000100 miRNA ATG14 autophagy down Homo sapiens prediction 9606 22863 ATG14L|BARKOR|KIAA0831 HGNC:19962|MIM:613515|Ensembl:ENSG00000126775|HPRD:13820|Vega:OTTHUMG00000172129 14 14q22.3 autophagy related 14 protein-coding autophagy related 14 hsa-miR-29b predicted by miR-29b (Bos taurus), and ATG14 predicted by ATG14 (Bos taurus) according to Pubmed ID (25234643) 3583 hsa-miR-195 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000461 miRNA ATG7 autophagy down Homo sapiens prediction 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 hsa-miR-195 predicted by miR-16 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23143396) 3584 hsa-miR-93 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000093 miRNA ATG16L1 autophagy down Homo sapiens prediction 9606 55054 APG16L|ATG16A|ATG16L|IBD10|WDR30 HGNC:21498|MIM:610767|Ensembl:ENSG00000085978|HPRD:16498|Vega:OTTHUMG00000133619 2 2q37.1 autophagy related 16-like 1 (S. cerevisiae) protein-coding autophagy related 16-like 1 (S. cerevisiae) hsa-miR-93 predicted by miR-106b (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 3585 hsa-miR-519d miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002853 miRNA ATG16L1 autophagy down Homo sapiens prediction 9606 55054 APG16L|ATG16A|ATG16L|IBD10|WDR30 HGNC:21498|MIM:610767|Ensembl:ENSG00000085978|HPRD:16498|Vega:OTTHUMG00000133619 2 2q37.1 autophagy related 16-like 1 (S. cerevisiae) protein-coding autophagy related 16-like 1 (S. cerevisiae) hsa-miR-519d predicted by miR-106b (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 3586 hsa-miR-520c-3p miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0002846 miRNA SQSTM1 autophagy down Homo sapiens prediction 9606 8878 A170|OSIL|PDB3|ZIP3|p60|p62|p62B HGNC:11280|MIM:601530|Ensembl:ENSG00000161011|HPRD:03319|Vega:OTTHUMG00000150643 5 5q35 sequestosome 1 protein-coding sequestosome 1 hsa-miR-520c-3p predicted by miR-372 (Homo sapiens), and SQSTM1 predicted by SQSTM1 (Homo sapiens) according to Pubmed ID (24991827) 3587 hsa-miR-132 miR-132/212/212-3p MIMAT0000426 miRNA FOXO3 autophagy down Homo sapiens prediction 9606 2309 AF6q21|FKHRL1|FKHRL1P2|FOXO2|FOXO3A HGNC:3821|MIM:602681|Ensembl:ENSG00000118689|HPRD:04061|Vega:OTTHUMG00000015327 6 6q21 forkhead box O3 protein-coding forkhead box O3 hsa-miR-132 predicted by miR-132 (Mus musculus), and FOXO3 predicted by Foxo3 (Mus musculus) according to Pubmed ID (23011132) 3588 hsa-miR-497 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0002820 miRNA BAG5 autophagy down Homo sapiens prediction 9606 9529 BAG-5 HGNC:941|MIM:603885|Ensembl:ENSG00000166170|HPRD:04862|Vega:OTTHUMG00000171763 14 14q32.33 BCL2-associated athanogene 5 protein-coding BCL2-associated athanogene 5 hsa-miR-497 predicted by miR-16 (Mus musculus), and BAG5 predicted by Bag5 (Mus musculus) according to Pubmed ID (21770019) 3589 hsa-miR-320b miR-320abcd/4429 MIMAT0005792 miRNA ULK1 autophagy down Homo sapiens prediction 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 hsa-miR-320b predicted by miR-320a (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (23622248) 3590 hsa-miR-3666 miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0018088 miRNA FYCO1 autophagy down Homo sapiens prediction 9606 79443 CATC2|CTRCT18|RUFY3|ZFYVE7 HGNC:14673|MIM:607182|Ensembl:ENSG00000163820|HPRD:06215|Vega:OTTHUMG00000133447 3 3p21.31 FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 hsa-miR-3666 predicted by miR-130b (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3591 hsa-miR-30b miR-30abcdef/30abe-5p/384-5p MIMAT0000420 miRNA ATG2B autophagy down Homo sapiens prediction 9606 55102 C14orf103 HGNC:20187|Ensembl:ENSG00000066739|HPRD:12626|Vega:OTTHUMG00000149933 14 14q32.2 autophagy related 2B protein-coding autophagy related 2B hsa-miR-30b predicted by mir-30d (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (23274497) 3592 hsa-miR-17 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000070 miRNA BECN1 autophagy down Homo sapiens prediction 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related hsa-miR-17 predicted by miR-20a (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (25485521) 3593 hsa-miR-520e miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0002825 miRNA ULK1 autophagy down Homo sapiens prediction 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 hsa-miR-520e predicted by miR-291 (Mus musculus), and ULK1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 3594 hsa-miR-148b miR-148ab-3p/152 MIMAT0000759 miRNA ATG14 autophagy down Homo sapiens prediction 9606 22863 ATG14L|BARKOR|KIAA0831 HGNC:19962|MIM:613515|Ensembl:ENSG00000126775|HPRD:13820|Vega:OTTHUMG00000172129 14 14q22.3 autophagy related 14 protein-coding autophagy related 14 hsa-miR-148b predicted by miR-152 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (25650716) 3595 hsa-miR-4429 miR-320abcd/4429 MIMAT0018944 miRNA ULK1 autophagy down Homo sapiens prediction 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 hsa-miR-4429 predicted by miR-320a (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (23622248) 3596 hsa-miR-93 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000093 miRNA SQSTM1 autophagy down Homo sapiens prediction 9606 8878 A170|OSIL|PDB3|ZIP3|p60|p62|p62B HGNC:11280|MIM:601530|Ensembl:ENSG00000161011|HPRD:03319|Vega:OTTHUMG00000150643 5 5q35 sequestosome 1 protein-coding sequestosome 1 hsa-miR-93 predicted by miR-106b (Homo sapiens),miR-106 (Mus musculus), and SQSTM1 predicted by Sqstm1 (Mus musculus),SQSTM1 (Homo sapiens) according to Pubmed ID (21628417),(22441107),(25485521),(25617127) 3597 hsa-miR-106a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000103 miRNA ATG16L1 autophagy down Homo sapiens prediction 9606 55054 APG16L|ATG16A|ATG16L|IBD10|WDR30 HGNC:21498|MIM:610767|Ensembl:ENSG00000085978|HPRD:16498|Vega:OTTHUMG00000133619 2 2q37.1 autophagy related 16-like 1 (S. cerevisiae) protein-coding autophagy related 16-like 1 (S. cerevisiae) hsa-miR-106a predicted by miR-106b (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 3598 hsa-miR-204 miR-204/204b/211 MIMAT0000265 miRNA MAP1LC3B autophagy down Homo sapiens prediction 9606 81631 ATG8F|LC3B|MAP1A/1BLC3|MAP1LC3B-a HGNC:13352|MIM:609604|Ensembl:ENSG00000140941|HPRD:14358|Vega:OTTHUMG00000137654 16 16q24.2 microtubule-associated protein 1 light chain 3 beta protein-coding microtubule-associated protein 1 light chain 3 beta hsa-miR-204 predicted by miR-204 (Homo sapiens),miR-204 (Rattus norvegicus), and MAP1LC3B predicted by Map1lc3b (Rattus norvegicus),MAP1LC3B (Homo sapiens) according to Pubmed ID (21316776),(21631941),(22516261),(25209181),(25517751) 3599 hsa-miR-449b miR-34ac/34bc-5p/449abc/449c-5p MIMAT0003327 miRNA ATG9A autophagy down Homo sapiens prediction 9606 79065 APG9L1|MGD3208|mATG9 HGNC:22408|MIM:612204|Ensembl:ENSG00000198925|HPRD:07979|Vega:OTTHUMG00000154557 2 2q35 autophagy related 9A protein-coding autophagy related 9A hsa-miR-449b predicted by miR-34a (Homo sapiens),miR-34a (Rattus norvegicus), and ATG9A predicted by Atg9a (Rattus norvegicus),ATG9A (Homo sapiens) according to Pubmed ID (22902544),(24728149),(24973144) 3600 hsa-miR-30b miR-30abcdef/30abe-5p/384-5p MIMAT0000420 miRNA MAP1LC3B autophagy down Homo sapiens prediction 9606 81631 ATG8F|LC3B|MAP1A/1BLC3|MAP1LC3B-a HGNC:13352|MIM:609604|Ensembl:ENSG00000140941|HPRD:14358|Vega:OTTHUMG00000137654 16 16q24.2 microtubule-associated protein 1 light chain 3 beta protein-coding microtubule-associated protein 1 light chain 3 beta hsa-miR-30b predicted by miR-30a (Homo sapiens), and MAP1LC3B predicted by MAP1LC3B (Homo sapiens) according to Pubmed ID (22135297) 3601 hsa-miR-181c miR-181abcd/4262 MIMAT0000258 miRNA UVRAG autophagy down Homo sapiens prediction 9606 7405 DHTX|VPS38|p63 HGNC:12640|MIM:602493|HPRD:03929 11 11q13.5 UV radiation resistance associated protein-coding UV radiation resistance associated hsa-miR-181c predicted by miR-181a (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22356768) 3602 hsa-miR-4500 let-7/98/4458/4500 MIMAT0019036 miRNA OLR1 autophagy down Homo sapiens prediction 9606 4973 CLEC8A|LOX1|LOXIN|SCARE1|SLOX1 HGNC:8133|MIM:602601|Ensembl:ENSG00000173391|HPRD:04003|Vega:OTTHUMG00000168527 12 12p13.2-p12.3 oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding oxidized low density lipoprotein (lectin-like) receptor 1 hsa-miR-4500 predicted by let-7g (Mus musculus), and OLR1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 3603 hsa-miR-199b-5p miR-199ab-5p MIMAT0000263 miRNA BECN1 autophagy down Homo sapiens prediction 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related hsa-miR-199b-5p predicted by miR-199a-5p (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (23337876) 3604 hsa-miR-17 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000070 miRNA ULK1 autophagy down Homo sapiens prediction 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 hsa-miR-17 predicted by miR-106b (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 3605 hsa-miR-520c-3p miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0002846 miRNA ULK1 autophagy down Homo sapiens prediction 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 hsa-miR-520c-3p predicted by miR-291 (Mus musculus), and ULK1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 3606 hsa-miR-30e miR-30abcdef/30abe-5p/384-5p MIMAT0000692 miRNA ATG5 autophagy down Homo sapiens prediction 9606 9474 APG5|APG5-LIKE|APG5L|ASP|hAPG5 HGNC:589|MIM:604261|Ensembl:ENSG00000057663|HPRD:16051|Vega:OTTHUMG00000016193 6 6q21 autophagy related 5 protein-coding autophagy related 5 hsa-miR-30e predicted by miR-30a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22395361),(22617440),(22902544),(23274497),(24148619) 3607 hsa-miR-215 miR-192/215 MIMAT0000272 miRNA MAP1LC3B autophagy down Homo sapiens prediction 9606 81631 ATG8F|LC3B|MAP1A/1BLC3|MAP1LC3B-a HGNC:13352|MIM:609604|Ensembl:ENSG00000140941|HPRD:14358|Vega:OTTHUMG00000137654 16 16q24.2 microtubule-associated protein 1 light chain 3 beta protein-coding microtubule-associated protein 1 light chain 3 beta hsa-miR-215 predicted by miR-192 (Homo sapiens), and MAP1LC3B predicted by MAP1LC3B (Homo sapiens) according to Pubmed ID (22135297) 3608 hsa-miR-519d miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002853 miRNA ULK1 autophagy down Homo sapiens prediction 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 hsa-miR-519d predicted by miR-106b (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 3609 hsa-miR-519d miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002853 miRNA HIF1A autophagy down Homo sapiens prediction 9606 3091 HIF-1A|HIF-1alpha|HIF1|HIF1-ALPHA|MOP1|PASD8|bHLHe78 HGNC:4910|MIM:603348|Ensembl:ENSG00000100644|HPRD:04517|Vega:OTTHUMG00000140344 14 14q23.2 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) hsa-miR-519d predicted by miR-20a (Homo sapiens), and HIF1A predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 3610 hsa-miR-497 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0002820 miRNA BCL2L2 autophagy down Homo sapiens prediction 9606 599 BCL-W|BCL2-L-2|BCLW|PPP1R51 HGNC:995|MIM:601931|Ensembl:ENSG00000129473|HPRD:03569|Vega:OTTHUMG00000028738 14 14q11.2-q12 BCL2-like 2 protein-coding BCL2-like 2 hsa-miR-497 predicted by miR-15b (Mus musculus), and BCL2L2 predicted by Bcl2l2 (Mus musculus) according to Pubmed ID (21770019) 3611 hsa-miR-519d miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002853 miRNA BECN1 autophagy down Homo sapiens prediction 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related hsa-miR-519d predicted by miR-17-5p (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (24755562),(25435430),(25485521) 3612 hsa-miR-17 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000070 miRNA ATG5 autophagy down Homo sapiens prediction 9606 9474 APG5|APG5-LIKE|APG5L|ASP|hAPG5 HGNC:589|MIM:604261|Ensembl:ENSG00000057663|HPRD:16051|Vega:OTTHUMG00000016193 6 6q21 autophagy related 5 protein-coding autophagy related 5 hsa-miR-17 predicted by miR-20a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (25485521) 3613 hsa-miR-181b miR-181abcd/4262 MIMAT0000257 miRNA ATG5 autophagy down Homo sapiens prediction 9606 9474 APG5|APG5-LIKE|APG5L|ASP|hAPG5 HGNC:589|MIM:604261|Ensembl:ENSG00000057663|HPRD:16051|Vega:OTTHUMG00000016193 6 6q21 autophagy related 5 protein-coding autophagy related 5 hsa-miR-181b predicted by miR-181a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22356768),(22902544),(23322078) 3614 hsa-miR-199a-5p miR-199ab-5p MIMAT0000231 miRNA HSPA5 autophagy down Homo sapiens prediction 9606 3309 BIP|GRP78|HEL-S-89n|MIF2 HGNC:5238|MIM:138120|Ensembl:ENSG00000044574|HPRD:00682|Vega:OTTHUMG00000020672 9 9q33.3 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) protein-coding heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) hsa-miR-199a-5p predicted by miR-199a-5p (Mus musculus), and HSPA5 predicted by Hspa5 (Mus musculus) according to Pubmed ID (23598416) 3615 hsa-let-7e let-7/98/4458/4500 MIMAT0000066 miRNA ATG4B autophagy down Homo sapiens prediction 9606 23192 APG4B|AUTL1 HGNC:20790|MIM:611338|Ensembl:ENSG00000168397|HPRD:16499|Vega:OTTHUMG00000151514 2 2q37.3 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase hsa-let-7e predicted by let-7b (Homo sapiens), and ATG4B predicted by ATG4B (Homo sapiens) according to Pubmed ID (22135297) 3616 hsa-miR-4262 miR-181abcd/4262 MIMAT0016894 miRNA ATG10 autophagy down Homo sapiens prediction 9606 83734 APG10|APG10L|pp12616 HGNC:20315|MIM:610800|Ensembl:ENSG00000152348|HPRD:16497|Vega:OTTHUMG00000119041 5 5q14.1 autophagy related 10 protein-coding autophagy related 10 hsa-miR-4262 predicted by miR-181a (Homo sapiens), and ATG10 predicted by ATG10 (Homo sapiens) according to Pubmed ID (22356768) 3617 hsa-miR-374b miR-374ab MIMAT0004955 miRNA ATG10 autophagy down Homo sapiens prediction 9606 83734 APG10|APG10L|pp12616 HGNC:20315|MIM:610800|Ensembl:ENSG00000152348|HPRD:16497|Vega:OTTHUMG00000119041 5 5q14.1 autophagy related 10 protein-coding autophagy related 10 hsa-miR-374b predicted by miR-374a (Homo sapiens), and ATG10 predicted by ATG10 (Homo sapiens) according to Pubmed ID (22356768) 3618 hsa-miR-519d miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002853 miRNA ATG7 autophagy down Homo sapiens prediction 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 hsa-miR-519d predicted by miR-17 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 3619 hsa-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000075 miRNA FYCO1 autophagy down Homo sapiens prediction 9606 79443 CATC2|CTRCT18|RUFY3|ZFYVE7 HGNC:14673|MIM:607182|Ensembl:ENSG00000163820|HPRD:06215|Vega:OTTHUMG00000133447 3 3p21.31 FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 hsa-miR-20a predicted by miR-93 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3620 hsa-miR-30e miR-30abcdef/30abe-5p/384-5p MIMAT0000692 miRNA BNIP3L autophagy down Homo sapiens prediction 9606 665 BNIP3a|NIX HGNC:1085|MIM:605368|Ensembl:ENSG00000104765|HPRD:07288|Vega:OTTHUMG00000099433 8 8p21 BCL2/adenovirus E1B 19kDa interacting protein 3-like protein-coding BCL2/adenovirus E1B 19kDa interacting protein 3-like hsa-miR-30e predicted by miR-30d (Homo sapiens), and BNIP3L predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 3621 hsa-miR-301b miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0004958 miRNA RB1CC1 autophagy down Homo sapiens prediction 9606 9821 ATG17|CC1|FIP200|PPP1R131 HGNC:15574|MIM:606837|Ensembl:ENSG00000023287|HPRD:06019|Vega:OTTHUMG00000164268 8 8q11 RB1-inducible coiled-coil 1 protein-coding RB1-inducible coiled-coil 1 hsa-miR-301b predicted by miR-133b (Homo sapiens), and RB1CC1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 3622 hsa-miR-16 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000069 miRNA BAG5 autophagy down Homo sapiens prediction 9606 9529 BAG-5 HGNC:941|MIM:603885|Ensembl:ENSG00000166170|HPRD:04862|Vega:OTTHUMG00000171763 14 14q32.33 BCL2-associated athanogene 5 protein-coding BCL2-associated athanogene 5 hsa-miR-16 predicted by miR-16 (Mus musculus), and BAG5 predicted by Bag5 (Mus musculus) according to Pubmed ID (21770019) 3623 hsa-miR-30b miR-30abcdef/30abe-5p/384-5p MIMAT0000420 miRNA ATG5 autophagy down Homo sapiens prediction 9606 9474 APG5|APG5-LIKE|APG5L|ASP|hAPG5 HGNC:589|MIM:604261|Ensembl:ENSG00000057663|HPRD:16051|Vega:OTTHUMG00000016193 6 6q21 autophagy related 5 protein-coding autophagy related 5 hsa-miR-30b predicted by miR-30a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22395361),(22617440),(22902544),(23274497),(24148619) 3624 hsa-miR-454 miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0003885 miRNA ATG2B autophagy down Homo sapiens prediction 9606 55102 C14orf103 HGNC:20187|Ensembl:ENSG00000066739|HPRD:12626|Vega:OTTHUMG00000149933 14 14q32.2 autophagy related 2B protein-coding autophagy related 2B hsa-miR-454 predicted by miR-130a (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (22902544) 3625 hsa-miR-30a miR-30abcdef/30abe-5p/384-5p MIMAT0000087 miRNA BECN1 autophagy down Homo sapiens prediction 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related hsa-miR-30a predicted by miR-30b (Homo sapiens),miR-30a (Mus musculus), and BECN1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (22647547),(23274497),(23326547),(24345332),(24771295),(25501305) 3626 hsa-miR-373 miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0000726 miRNA ULK1 autophagy down Homo sapiens prediction 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 hsa-miR-373 predicted by miR-291 (Mus musculus), and ULK1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 3627 hsa-miR-98 let-7/98/4458/4500 MIMAT0000096 miRNA IGF1R autophagy down Homo sapiens prediction 9606 3480 CD221|IGFIR|IGFR|JTK13 HGNC:5465|MIM:147370|Ensembl:ENSG00000140443|HPRD:00932|Vega:OTTHUMG00000149851 15 15q26.3 insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor hsa-miR-98 predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 3628 hsa-miR-520b miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0002843 miRNA SQSTM1 autophagy down Homo sapiens prediction 9606 8878 A170|OSIL|PDB3|ZIP3|p60|p62|p62B HGNC:11280|MIM:601530|Ensembl:ENSG00000161011|HPRD:03319|Vega:OTTHUMG00000150643 5 5q35 sequestosome 1 protein-coding sequestosome 1 hsa-miR-520b predicted by miR-372 (Homo sapiens), and SQSTM1 predicted by SQSTM1 (Homo sapiens) according to Pubmed ID (24991827) 3629 hsa-miR-373 miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0000726 miRNA SQSTM1 autophagy down Homo sapiens prediction 9606 8878 A170|OSIL|PDB3|ZIP3|p60|p62|p62B HGNC:11280|MIM:601530|Ensembl:ENSG00000161011|HPRD:03319|Vega:OTTHUMG00000150643 5 5q35 sequestosome 1 protein-coding sequestosome 1 hsa-miR-373 predicted by miR-372 (Homo sapiens), and SQSTM1 predicted by SQSTM1 (Homo sapiens) according to Pubmed ID (24991827) 3630 hsa-miR-181d miR-181abcd/4262 MIMAT0002821 miRNA TP63 autophagy down Homo sapiens prediction 9606 8626 AIS|B(p51A)|B(p51B)|EEC3|KET|LMS|NBP|OFC8|RHS|SHFM4|TP53CP|TP53L|TP73L|p40|p51|p53CP|p63|p73H|p73L HGNC:15979|MIM:603273|Ensembl:ENSG00000073282|HPRD:04469|Vega:OTTHUMG00000156313 3 3q28 tumor protein p63 protein-coding tumor protein p63 hsa-miR-181d predicted by miR-181a (Homo sapiens), and TP63 predicted by TP63 (Homo sapiens) according to Pubmed ID (22356768) 3631 hsa-miR-30c miR-30abcdef/30abe-5p/384-5p MIMAT0000244 miRNA ATG12 autophagy down Homo sapiens prediction 9606 9140 APG12|APG12L|FBR93|HAPG12 HGNC:588|MIM:609608|Ensembl:ENSG00000145782|HPRD:08496|Vega:OTTHUMG00000128889 5 5q21-q22 autophagy related 12 protein-coding autophagy related 12 hsa-miR-30c predicted by miR-30b (Homo sapiens), and ATG12 predicted by ATG12 (Homo sapiens) according to Pubmed ID (22647547),(23274497) 3632 hsa-miR-17 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000070 miRNA FYCO1 autophagy down Homo sapiens prediction 9606 79443 CATC2|CTRCT18|RUFY3|ZFYVE7 HGNC:14673|MIM:607182|Ensembl:ENSG00000163820|HPRD:06215|Vega:OTTHUMG00000133447 3 3p21.31 FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 hsa-miR-17 predicted by miR-93 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3633 hsa-miR-200b miR-200bc/429/548a MIMAT0000318 miRNA HMOX1 autophagy down Homo sapiens prediction 9606 3162 HMOX1D|HO-1|HSP32|bK286B10 HGNC:5013|MIM:141250|Ensembl:ENSG00000100292|HPRD:00782|Vega:OTTHUMG00000150960 22 22q13.1 heme oxygenase (decycling) 1 protein-coding heme oxygenase (decycling) 1 hsa-miR-200b predicted by miR-200c (Homo sapiens), and HMOX1 predicted by HMOX1 (Homo sapiens) according to Pubmed ID (25150313) 3634 hsa-miR-363 miR-25/32/92abc/363/363-3p/367 MIMAT0000707 miRNA UVRAG autophagy down Homo sapiens prediction 9606 7405 DHTX|VPS38|p63 HGNC:12640|MIM:602493|HPRD:03929 11 11q13.5 UV radiation resistance associated protein-coding UV radiation resistance associated hsa-miR-363 predicted by miR-32 (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22135297) 3635 hsa-miR-17 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000070 miRNA HIF1A autophagy down Homo sapiens prediction 9606 3091 HIF-1A|HIF-1alpha|HIF1|HIF1-ALPHA|MOP1|PASD8|bHLHe78 HGNC:4910|MIM:603348|Ensembl:ENSG00000100644|HPRD:04517|Vega:OTTHUMG00000140344 14 14q23.2 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) hsa-miR-17 predicted by miR-20a (Homo sapiens), and HIF1A predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 3636 hsa-miR-99a miR-99ab/100 MIMAT0000097 miRNA IGF1R autophagy down Homo sapiens prediction 9606 3480 CD221|IGFIR|IGFR|JTK13 HGNC:5465|MIM:147370|Ensembl:ENSG00000140443|HPRD:00932|Vega:OTTHUMG00000149851 15 15q26.3 insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor hsa-miR-99a predicted by miR-100 (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25026290) 3637 hsa-miR-106a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000103 miRNA BECN1 autophagy down Homo sapiens prediction 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related hsa-miR-106a predicted by miR-17-5p (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (24755562),(25435430),(25485521) 3638 hsa-miR-429 miR-200bc/429/548a MIMAT0001536 miRNA UBQLN1 autophagy down Homo sapiens prediction 9606 29979 DA41|DSK2|PLIC-1|UBQN|XDRP1 HGNC:12508|MIM:605046|Ensembl:ENSG00000135018|HPRD:05440|Vega:OTTHUMG00000020104 9 9q22|9q21.2-q21.3 ubiquilin 1 protein-coding ubiquilin 1 hsa-miR-429 predicted by miR-200c (Homo sapiens), and UBQLN1 predicted by UBQLN1 (Homo sapiens) according to Pubmed ID (25044403) 3639 hsa-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0001413 miRNA SQSTM1 autophagy down Homo sapiens prediction 9606 8878 A170|OSIL|PDB3|ZIP3|p60|p62|p62B HGNC:11280|MIM:601530|Ensembl:ENSG00000161011|HPRD:03319|Vega:OTTHUMG00000150643 5 5q35 sequestosome 1 protein-coding sequestosome 1 hsa-miR-20b predicted by miR-106b (Homo sapiens),miR-106 (Mus musculus), and SQSTM1 predicted by Sqstm1 (Mus musculus),SQSTM1 (Homo sapiens) according to Pubmed ID (21628417),(22441107),(25485521),(25617127) 3640 hsa-miR-23a miR-23abc/23b-3p MIMAT0000078 miRNA ATG12 autophagy down Homo sapiens prediction 9606 9140 APG12|APG12L|FBR93|HAPG12 HGNC:588|MIM:609608|Ensembl:ENSG00000145782|HPRD:08496|Vega:OTTHUMG00000128889 5 5q21-q22 autophagy related 12 protein-coding autophagy related 12 hsa-miR-23a predicted by miR-23b (Homo sapiens), and ATG12 predicted by ATG12 (Homo sapiens) according to Pubmed ID (23916944),(24145177) 3641 hsa-miR-34a miR-34ac/34bc-5p/449abc/449c-5p MIMAT0000255 miRNA ATG9A autophagy down Homo sapiens prediction 9606 79065 APG9L1|MGD3208|mATG9 HGNC:22408|MIM:612204|Ensembl:ENSG00000198925|HPRD:07979|Vega:OTTHUMG00000154557 2 2q35 autophagy related 9A protein-coding autophagy related 9A hsa-miR-34a predicted by miR-34a (Rattus norvegicus), and ATG9A predicted by Atg9a (Rattus norvegicus) according to Pubmed ID (24728149),(24973144) 3642 hsa-miR-302b miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0000715 miRNA FYCO1 autophagy down Homo sapiens prediction 9606 79443 CATC2|CTRCT18|RUFY3|ZFYVE7 HGNC:14673|MIM:607182|Ensembl:ENSG00000163820|HPRD:06215|Vega:OTTHUMG00000133447 3 3p21.31 FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 hsa-miR-302b predicted by miR-373 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3643 hsa-miR-93 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000093 miRNA HIF1A autophagy down Homo sapiens prediction 9606 3091 HIF-1A|HIF-1alpha|HIF1|HIF1-ALPHA|MOP1|PASD8|bHLHe78 HGNC:4910|MIM:603348|Ensembl:ENSG00000100644|HPRD:04517|Vega:OTTHUMG00000140344 14 14q23.2 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) hsa-miR-93 predicted by miR-20a (Homo sapiens), and HIF1A predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 3644 hsa-miR-424 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0001341 miRNA BAG5 autophagy down Homo sapiens prediction 9606 9529 BAG-5 HGNC:941|MIM:603885|Ensembl:ENSG00000166170|HPRD:04862|Vega:OTTHUMG00000171763 14 14q32.33 BCL2-associated athanogene 5 protein-coding BCL2-associated athanogene 5 hsa-miR-424 predicted by miR-16 (Mus musculus), and BAG5 predicted by Bag5 (Mus musculus) according to Pubmed ID (21770019) 3645 hsa-let-7c let-7/98/4458/4500 MIMAT0000064 miRNA OLR1 autophagy down Homo sapiens prediction 9606 4973 CLEC8A|LOX1|LOXIN|SCARE1|SLOX1 HGNC:8133|MIM:602601|Ensembl:ENSG00000173391|HPRD:04003|Vega:OTTHUMG00000168527 12 12p13.2-p12.3 oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding oxidized low density lipoprotein (lectin-like) receptor 1 hsa-let-7c predicted by let-7g (Mus musculus), and OLR1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 3646 hsa-miR-4500 let-7/98/4458/4500 MIMAT0019036 miRNA IGF1R autophagy down Homo sapiens prediction 9606 3480 CD221|IGFIR|IGFR|JTK13 HGNC:5465|MIM:147370|Ensembl:ENSG00000140443|HPRD:00932|Vega:OTTHUMG00000149851 15 15q26.3 insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor hsa-miR-4500 predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 3647 hsa-miR-520a-3p miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0002834 miRNA ULK1 autophagy down Homo sapiens prediction 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 hsa-miR-520a-3p predicted by miR-291 (Mus musculus), and ULK1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 3648 hsa-miR-302a miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0000684 miRNA SQSTM1 autophagy down Homo sapiens prediction 9606 8878 A170|OSIL|PDB3|ZIP3|p60|p62|p62B HGNC:11280|MIM:601530|Ensembl:ENSG00000161011|HPRD:03319|Vega:OTTHUMG00000150643 5 5q35 sequestosome 1 protein-coding sequestosome 1 hsa-miR-302a predicted by miR-372 (Homo sapiens), and SQSTM1 predicted by SQSTM1 (Homo sapiens) according to Pubmed ID (24991827) 3649 hsa-miR-506 miR-124/124ab/506 MIMAT0002878 miRNA ANTXR2 autophagy down Homo sapiens prediction 9606 118429 CMG-2|CMG2|HFS|ISH|JHF HGNC:21732|MIM:608041|Ensembl:ENSG00000163297|HPRD:07452|Vega:OTTHUMG00000151982 4 4q21.21 anthrax toxin receptor 2 protein-coding anthrax toxin receptor 2 hsa-miR-506 predicted by miR-124 (Homo sapiens), and ANTXR2 predicted by ANTXR2 (Homo sapiens) according to Pubmed ID (25736362) 3650 hsa-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000075 miRNA ATG7 autophagy down Homo sapiens prediction 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 hsa-miR-20a predicted by miR-17 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 3651 hsa-miR-302d miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0000718 miRNA ATG7 autophagy down Homo sapiens prediction 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 hsa-miR-302d predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 3652 hsa-miR-497 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0002820 miRNA ATG7 autophagy down Homo sapiens prediction 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 hsa-miR-497 predicted by miR-16 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23143396) 3653 hsa-miR-93 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000093 miRNA BECN1 autophagy down Homo sapiens prediction 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related hsa-miR-93 predicted by miR-17-5p (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (24755562),(25435430),(25485521) 3654 hsa-miR-302e miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0005931 miRNA ATG7 autophagy down Homo sapiens prediction 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 hsa-miR-302e predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 3655 hsa-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000075 miRNA ATG16L1 autophagy down Homo sapiens prediction 9606 55054 APG16L|ATG16A|ATG16L|IBD10|WDR30 HGNC:21498|MIM:610767|Ensembl:ENSG00000085978|HPRD:16498|Vega:OTTHUMG00000133619 2 2q37.1 autophagy related 16-like 1 (S. cerevisiae) protein-coding autophagy related 16-like 1 (S. cerevisiae) hsa-miR-20a predicted by miR-106b (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 3656 hsa-miR-30a miR-30abcdef/30abe-5p/384-5p MIMAT0000087 miRNA ATG12 autophagy down Homo sapiens prediction 9606 9140 APG12|APG12L|FBR93|HAPG12 HGNC:588|MIM:609608|Ensembl:ENSG00000145782|HPRD:08496|Vega:OTTHUMG00000128889 5 5q21-q22 autophagy related 12 protein-coding autophagy related 12 hsa-miR-30a predicted by miR-30b (Homo sapiens), and ATG12 predicted by ATG12 (Homo sapiens) according to Pubmed ID (22647547),(23274497) 3657 hsa-miR-30a miR-30abcdef/30abe-5p/384-5p MIMAT0000087 miRNA BNIP3L autophagy down Homo sapiens prediction 9606 665 BNIP3a|NIX HGNC:1085|MIM:605368|Ensembl:ENSG00000104765|HPRD:07288|Vega:OTTHUMG00000099433 8 8p21 BCL2/adenovirus E1B 19kDa interacting protein 3-like protein-coding BCL2/adenovirus E1B 19kDa interacting protein 3-like hsa-miR-30a predicted by miR-30d (Homo sapiens), and BNIP3L predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 3658 hsa-miR-4458 let-7/98/4458/4500 MIMAT0018980 miRNA ATG4B autophagy down Homo sapiens prediction 9606 23192 APG4B|AUTL1 HGNC:20790|MIM:611338|Ensembl:ENSG00000168397|HPRD:16499|Vega:OTTHUMG00000151514 2 2q37.3 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase hsa-miR-4458 predicted by let-7b (Homo sapiens), and ATG4B predicted by ATG4B (Homo sapiens) according to Pubmed ID (22135297) 3659 hsa-miR-302d miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0000718 miRNA SQSTM1 autophagy down Homo sapiens prediction 9606 8878 A170|OSIL|PDB3|ZIP3|p60|p62|p62B HGNC:11280|MIM:601530|Ensembl:ENSG00000161011|HPRD:03319|Vega:OTTHUMG00000150643 5 5q35 sequestosome 1 protein-coding sequestosome 1 hsa-miR-302d predicted by miR-372 (Homo sapiens), and SQSTM1 predicted by SQSTM1 (Homo sapiens) according to Pubmed ID (24991827) 3660 hsa-miR-4295 miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0016844 miRNA RB1CC1 autophagy down Homo sapiens prediction 9606 9821 ATG17|CC1|FIP200|PPP1R131 HGNC:15574|MIM:606837|Ensembl:ENSG00000023287|HPRD:06019|Vega:OTTHUMG00000164268 8 8q11 RB1-inducible coiled-coil 1 protein-coding RB1-inducible coiled-coil 1 hsa-miR-4295 predicted by miR-133b (Homo sapiens), and RB1CC1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 3661 hsa-miR-15b miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000417 miRNA ATG14 autophagy down Homo sapiens prediction 9606 22863 ATG14L|BARKOR|KIAA0831 HGNC:19962|MIM:613515|Ensembl:ENSG00000126775|HPRD:13820|Vega:OTTHUMG00000172129 14 14q22.3 autophagy related 14 protein-coding autophagy related 14 hsa-miR-15b predicted by miR-195 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 3662 hsa-miR-99a miR-99ab/100 MIMAT0000097 miRNA MTOR autophagy down Homo sapiens prediction 9606 2475 FRAP|FRAP1|FRAP2|RAFT1|RAPT1 HGNC:3942|MIM:601231|Ensembl:ENSG00000198793|HPRD:03134|Vega:OTTHUMG00000002001 1 1p36.2 mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) hsa-miR-99a predicted by miR-100 (Homo sapiens), and MTOR predicted by MTOR (Homo sapiens) according to Pubmed ID (25026290) 3663 hsa-miR-519d miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002853 miRNA FYCO1 autophagy down Homo sapiens prediction 9606 79443 CATC2|CTRCT18|RUFY3|ZFYVE7 HGNC:14673|MIM:607182|Ensembl:ENSG00000163820|HPRD:06215|Vega:OTTHUMG00000133447 3 3p21.31 FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 hsa-miR-519d predicted by miR-93 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3664 hsa-miR-211 miR-204/204b/211 MIMAT0000268 miRNA CAV1 autophagy down Homo sapiens prediction 9606 857 BSCL3|CGL3|LCCNS|MSTP085|PPH3|VIP21 HGNC:1527|MIM:601047|Ensembl:ENSG00000105974|HPRD:03028|Vega:OTTHUMG00000023413 7 7q31.1 caveolin 1, caveolae protein, 22kDa protein-coding caveolin 1, caveolae protein, 22kDa hsa-miR-211 predicted by miR-204 (Homo sapiens), and CAV1 predicted by CAV1 (Homo sapiens) according to Pubmed ID (25517751) 3665 hsa-miR-19a miR-19ab MIMAT0000073 miRNA ULK1 autophagy down Homo sapiens prediction 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 hsa-miR-19a predicted by miR-19b (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (25617127) 3666 hsa-miR-148a miR-148ab-3p/152 MIMAT0000243 miRNA ATG14 autophagy down Homo sapiens prediction 9606 22863 ATG14L|BARKOR|KIAA0831 HGNC:19962|MIM:613515|Ensembl:ENSG00000126775|HPRD:13820|Vega:OTTHUMG00000172129 14 14q22.3 autophagy related 14 protein-coding autophagy related 14 hsa-miR-148a predicted by miR-152 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (25650716) 3667 hsa-miR-590-5p miR-21/590-5p MIMAT0003258 miRNA BCL2 autophagy down Homo sapiens prediction 9606 596 Bcl-2|PPP1R50 HGNC:990|MIM:151430|Ensembl:ENSG00000171791|HPRD:01045 18 18q21.3 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 hsa-miR-590-5p predicted by miR-21 (Homo sapiens), and BCL2 predicted by BCL2 (Homo sapiens) according to Pubmed ID (23834154) 3668 hsa-miR-30e miR-30abcdef/30abe-5p/384-5p MIMAT0000692 miRNA BECN1 autophagy down Homo sapiens prediction 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related hsa-miR-30e predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and BECN1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 3669 hsa-miR-302d miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0000718 miRNA FYCO1 autophagy down Homo sapiens prediction 9606 79443 CATC2|CTRCT18|RUFY3|ZFYVE7 HGNC:14673|MIM:607182|Ensembl:ENSG00000163820|HPRD:06215|Vega:OTTHUMG00000133447 3 3p21.31 FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 hsa-miR-302d predicted by miR-373 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3670 hsa-miR-34c-5p miR-34ac/34bc-5p/449abc/449c-5p MIMAT0000686 miRNA ATG4B autophagy down Homo sapiens prediction 9606 23192 APG4B|AUTL1 HGNC:20790|MIM:611338|Ensembl:ENSG00000168397|HPRD:16499|Vega:OTTHUMG00000151514 2 2q37.3 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase hsa-miR-34c-5p predicted by miR-34a (Homo sapiens), and ATG4B predicted by ATG4B (Homo sapiens) according to Pubmed ID (24755409) 3671 hsa-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0001413 miRNA ATG16L1 autophagy down Homo sapiens prediction 9606 55054 APG16L|ATG16A|ATG16L|IBD10|WDR30 HGNC:21498|MIM:610767|Ensembl:ENSG00000085978|HPRD:16498|Vega:OTTHUMG00000133619 2 2q37.1 autophagy related 16-like 1 (S. cerevisiae) protein-coding autophagy related 16-like 1 (S. cerevisiae) hsa-miR-20b predicted by miR-106b (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 3672 hsa-miR-29a miR-29abcd MIMAT0000086 miRNA ATG14 autophagy down Homo sapiens prediction 9606 22863 ATG14L|BARKOR|KIAA0831 HGNC:19962|MIM:613515|Ensembl:ENSG00000126775|HPRD:13820|Vega:OTTHUMG00000172129 14 14q22.3 autophagy related 14 protein-coding autophagy related 14 hsa-miR-29a predicted by miR-29b (Bos taurus), and ATG14 predicted by ATG14 (Bos taurus) according to Pubmed ID (25234643) 3673 hsa-miR-181b miR-181abcd/4262 MIMAT0000257 miRNA UVRAG autophagy down Homo sapiens prediction 9606 7405 DHTX|VPS38|p63 HGNC:12640|MIM:602493|HPRD:03929 11 11q13.5 UV radiation resistance associated protein-coding UV radiation resistance associated hsa-miR-181b predicted by miR-181a (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22356768) 3674 hsa-miR-222 miR-221/222/222ab/1928 MIMAT0000279 miRNA CDKN1B autophagy down Homo sapiens prediction 9606 1027 CDKN4|KIP1|MEN1B|MEN4|P27KIP1 HGNC:1785|MIM:600778|Ensembl:ENSG00000111276|HPRD:02867|Vega:OTTHUMG00000149914 12 12p13.1-p12 cyclin-dependent kinase inhibitor 1B (p27, Kip1) protein-coding cyclin-dependent kinase inhibitor 1B (p27, Kip1) hsa-miR-222 predicted by miR-221 (Homo sapiens), and CDKN1B predicted by CDKN1B (Homo sapiens) according to Pubmed ID (25394488) 3675 hsa-miR-454 miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0003885 miRNA FYCO1 autophagy down Homo sapiens prediction 9606 79443 CATC2|CTRCT18|RUFY3|ZFYVE7 HGNC:14673|MIM:607182|Ensembl:ENSG00000163820|HPRD:06215|Vega:OTTHUMG00000133447 3 3p21.31 FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 hsa-miR-454 predicted by miR-130b (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3676 hsa-miR-181d miR-181abcd/4262 MIMAT0002821 miRNA ATG5 autophagy down Homo sapiens prediction 9606 9474 APG5|APG5-LIKE|APG5L|ASP|hAPG5 HGNC:589|MIM:604261|Ensembl:ENSG00000057663|HPRD:16051|Vega:OTTHUMG00000016193 6 6q21 autophagy related 5 protein-coding autophagy related 5 hsa-miR-181d predicted by miR-181a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22356768),(22902544),(23322078) 3677 hsa-miR-92a miR-25/32/92abc/363/363-3p/367 MIMAT0000092 miRNA UVRAG autophagy down Homo sapiens prediction 9606 7405 DHTX|VPS38|p63 HGNC:12640|MIM:602493|HPRD:03929 11 11q13.5 UV radiation resistance associated protein-coding UV radiation resistance associated hsa-miR-92a predicted by miR-32 (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22135297) 3678 hsa-miR-181b miR-181abcd/4262 MIMAT0000257 miRNA ATG10 autophagy down Homo sapiens prediction 9606 83734 APG10|APG10L|pp12616 HGNC:20315|MIM:610800|Ensembl:ENSG00000152348|HPRD:16497|Vega:OTTHUMG00000119041 5 5q14.1 autophagy related 10 protein-coding autophagy related 10 hsa-miR-181b predicted by miR-181a (Homo sapiens), and ATG10 predicted by ATG10 (Homo sapiens) according to Pubmed ID (22356768) 3679 hsa-miR-302b miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0000715 miRNA ULK1 autophagy down Homo sapiens prediction 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 hsa-miR-302b predicted by miR-291 (Mus musculus), and ULK1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 3680 hsa-miR-98 let-7/98/4458/4500 MIMAT0000096 miRNA OLR1 autophagy down Homo sapiens prediction 9606 4973 CLEC8A|LOX1|LOXIN|SCARE1|SLOX1 HGNC:8133|MIM:602601|Ensembl:ENSG00000173391|HPRD:04003|Vega:OTTHUMG00000168527 12 12p13.2-p12.3 oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding oxidized low density lipoprotein (lectin-like) receptor 1 hsa-miR-98 predicted by let-7g (Mus musculus), and OLR1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 3681 hsa-miR-30e miR-30abcdef/30abe-5p/384-5p MIMAT0000692 miRNA ATG2B autophagy down Homo sapiens prediction 9606 55102 C14orf103 HGNC:20187|Ensembl:ENSG00000066739|HPRD:12626|Vega:OTTHUMG00000149933 14 14q32.2 autophagy related 2B protein-coding autophagy related 2B hsa-miR-30e predicted by mir-30d (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (23274497) 3682 hsa-miR-29a miR-29abcd MIMAT0000086 miRNA ATG9A autophagy down Homo sapiens prediction 9606 79065 APG9L1|MGD3208|mATG9 HGNC:22408|MIM:612204|Ensembl:ENSG00000198925|HPRD:07979|Vega:OTTHUMG00000154557 2 2q35 autophagy related 9A protein-coding autophagy related 9A hsa-miR-29a predicted by miR-29b (Bos taurus), and ATG9A predicted by ATG9A (Bos taurus) according to Pubmed ID (25234643) 3683 hsa-miR-302c miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0000717 miRNA ATG7 autophagy down Homo sapiens prediction 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 hsa-miR-302c predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 3684 hsa-miR-25 miR-25/32/92abc/363/363-3p/367 MIMAT0000081 miRNA UVRAG autophagy down Homo sapiens prediction 9606 7405 DHTX|VPS38|p63 HGNC:12640|MIM:602493|HPRD:03929 11 11q13.5 UV radiation resistance associated protein-coding UV radiation resistance associated hsa-miR-25 predicted by miR-32 (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22135297) 3685 hsa-miR-130b miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0000691 miRNA ATG2B autophagy down Homo sapiens prediction 9606 55102 C14orf103 HGNC:20187|Ensembl:ENSG00000066739|HPRD:12626|Vega:OTTHUMG00000149933 14 14q32.2 autophagy related 2B protein-coding autophagy related 2B hsa-miR-130b predicted by miR-130a (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (22902544) 3686 hsa-miR-106a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000103 miRNA ATG5 autophagy down Homo sapiens prediction 9606 9474 APG5|APG5-LIKE|APG5L|ASP|hAPG5 HGNC:589|MIM:604261|Ensembl:ENSG00000057663|HPRD:16051|Vega:OTTHUMG00000016193 6 6q21 autophagy related 5 protein-coding autophagy related 5 hsa-miR-106a predicted by miR-20a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (25485521) 3687 hsa-miR-23c miR-23abc/23b-3p MIMAT0018000 miRNA ATG12 autophagy down Homo sapiens prediction 9606 9140 APG12|APG12L|FBR93|HAPG12 HGNC:588|MIM:609608|Ensembl:ENSG00000145782|HPRD:08496|Vega:OTTHUMG00000128889 5 5q21-q22 autophagy related 12 protein-coding autophagy related 12 hsa-miR-23c predicted by miR-23b (Homo sapiens), and ATG12 predicted by ATG12 (Homo sapiens) according to Pubmed ID (23916944),(24145177) 3688 hsa-miR-181d miR-181abcd/4262 MIMAT0002821 miRNA UVRAG autophagy down Homo sapiens prediction 9606 7405 DHTX|VPS38|p63 HGNC:12640|MIM:602493|HPRD:03929 11 11q13.5 UV radiation resistance associated protein-coding UV radiation resistance associated hsa-miR-181d predicted by miR-181a (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22356768) 3689 hsa-miR-17 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000070 miRNA ATG7 autophagy down Homo sapiens prediction 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 hsa-miR-17 predicted by miR-20a (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (25485521),(25617127) 3690 hsa-miR-17 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000070 miRNA ATG16L1 autophagy down Homo sapiens prediction 9606 55054 APG16L|ATG16A|ATG16L|IBD10|WDR30 HGNC:21498|MIM:610767|Ensembl:ENSG00000085978|HPRD:16498|Vega:OTTHUMG00000133619 2 2q37.1 autophagy related 16-like 1 (S. cerevisiae) protein-coding autophagy related 16-like 1 (S. cerevisiae) hsa-miR-17 predicted by miR-106b (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 3691 hsa-miR-520e miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0002825 miRNA ATG7 autophagy down Homo sapiens prediction 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 hsa-miR-520e predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 3692 hsa-miR-106a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000103 miRNA ATG7 autophagy down Homo sapiens prediction 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 hsa-miR-106a predicted by miR-17 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 3693 hsa-miR-200b miR-200bc/429/548a MIMAT0000318 miRNA UBQLN1 autophagy down Homo sapiens prediction 9606 29979 DA41|DSK2|PLIC-1|UBQN|XDRP1 HGNC:12508|MIM:605046|Ensembl:ENSG00000135018|HPRD:05440|Vega:OTTHUMG00000020104 9 9q22|9q21.2-q21.3 ubiquilin 1 protein-coding ubiquilin 1 hsa-miR-200b predicted by miR-200c (Homo sapiens), and UBQLN1 predicted by UBQLN1 (Homo sapiens) according to Pubmed ID (25044403) 3694 hsa-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000680 miRNA ATG7 autophagy down Homo sapiens prediction 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 hsa-miR-106b predicted by miR-17 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 3695 hsa-let-7d let-7/98/4458/4500 MIMAT0000065 miRNA OLR1 autophagy down Homo sapiens prediction 9606 4973 CLEC8A|LOX1|LOXIN|SCARE1|SLOX1 HGNC:8133|MIM:602601|Ensembl:ENSG00000173391|HPRD:04003|Vega:OTTHUMG00000168527 12 12p13.2-p12.3 oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding oxidized low density lipoprotein (lectin-like) receptor 1 hsa-let-7d predicted by let-7g (Mus musculus), and OLR1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 3696 hsa-miR-16 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000069 miRNA ATG14 autophagy down Homo sapiens prediction 9606 22863 ATG14L|BARKOR|KIAA0831 HGNC:19962|MIM:613515|Ensembl:ENSG00000126775|HPRD:13820|Vega:OTTHUMG00000172129 14 14q22.3 autophagy related 14 protein-coding autophagy related 14 hsa-miR-16 predicted by miR-195 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 3697 hsa-miR-320c miR-320abcd/4429 MIMAT0005793 miRNA ULK1 autophagy down Homo sapiens prediction 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 hsa-miR-320c predicted by miR-320a (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (23622248) 3698 hsa-miR-301a miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0000688 miRNA FYCO1 autophagy down Homo sapiens prediction 9606 79443 CATC2|CTRCT18|RUFY3|ZFYVE7 HGNC:14673|MIM:607182|Ensembl:ENSG00000163820|HPRD:06215|Vega:OTTHUMG00000133447 3 3p21.31 FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 hsa-miR-301a predicted by miR-130b (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3699 hsa-miR-29c miR-29abcd MIMAT0000681 miRNA PSME4 autophagy down Homo sapiens prediction 9606 23198 PA200 HGNC:20635|MIM:607705|Ensembl:ENSG00000068878|HPRD:09652|Vega:OTTHUMG00000151852 2 2p16.2 proteasome (prosome, macropain) activator subunit 4 protein-coding proteasome (prosome, macropain) activator subunit 4 hsa-miR-29c predicted by miR-29b (Homo sapiens), and PSME4 predicted by PSME4 (Homo sapiens) according to Pubmed ID (25234165) 3700 hsa-miR-29c miR-29abcd MIMAT0000681 miRNA ATG14 autophagy down Homo sapiens prediction 9606 22863 ATG14L|BARKOR|KIAA0831 HGNC:19962|MIM:613515|Ensembl:ENSG00000126775|HPRD:13820|Vega:OTTHUMG00000172129 14 14q22.3 autophagy related 14 protein-coding autophagy related 14 hsa-miR-29c predicted by miR-29b (Bos taurus), and ATG14 predicted by ATG14 (Bos taurus) according to Pubmed ID (25234643) 3701 hsa-miR-17 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000070 miRNA SQSTM1 autophagy down Homo sapiens prediction 9606 8878 A170|OSIL|PDB3|ZIP3|p60|p62|p62B HGNC:11280|MIM:601530|Ensembl:ENSG00000161011|HPRD:03319|Vega:OTTHUMG00000150643 5 5q35 sequestosome 1 protein-coding sequestosome 1 hsa-miR-17 predicted by miR-106b (Homo sapiens),miR-106 (Mus musculus), and SQSTM1 predicted by Sqstm1 (Mus musculus),SQSTM1 (Homo sapiens) according to Pubmed ID (21628417),(22441107),(25485521),(25617127) 3702 hsa-miR-519d miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0002853 miRNA ATG5 autophagy down Homo sapiens prediction 9606 9474 APG5|APG5-LIKE|APG5L|ASP|hAPG5 HGNC:589|MIM:604261|Ensembl:ENSG00000057663|HPRD:16051|Vega:OTTHUMG00000016193 6 6q21 autophagy related 5 protein-coding autophagy related 5 hsa-miR-519d predicted by miR-20a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (25485521) 3703 hsa-let-7f let-7/98/4458/4500 MIMAT0000067 miRNA ATG4B autophagy down Homo sapiens prediction 9606 23192 APG4B|AUTL1 HGNC:20790|MIM:611338|Ensembl:ENSG00000168397|HPRD:16499|Vega:OTTHUMG00000151514 2 2q37.3 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase hsa-let-7f predicted by let-7b (Homo sapiens), and ATG4B predicted by ATG4B (Homo sapiens) according to Pubmed ID (22135297) 3704 hsa-let-7i let-7/98/4458/4500 MIMAT0000415 miRNA ATG4B autophagy down Homo sapiens prediction 9606 23192 APG4B|AUTL1 HGNC:20790|MIM:611338|Ensembl:ENSG00000168397|HPRD:16499|Vega:OTTHUMG00000151514 2 2q37.3 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase hsa-let-7i predicted by let-7b (Homo sapiens), and ATG4B predicted by ATG4B (Homo sapiens) according to Pubmed ID (22135297) 3705 hsa-miR-16 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000069 miRNA BCL2L2 autophagy down Homo sapiens prediction 9606 599 BCL-W|BCL2-L-2|BCLW|PPP1R51 HGNC:995|MIM:601931|Ensembl:ENSG00000129473|HPRD:03569|Vega:OTTHUMG00000028738 14 14q11.2-q12 BCL2-like 2 protein-coding BCL2-like 2 hsa-miR-16 predicted by miR-15b (Mus musculus), and BCL2L2 predicted by Bcl2l2 (Mus musculus) according to Pubmed ID (21770019) 3706 hsa-miR-590-5p miR-21/590-5p MIMAT0003258 miRNA PTEN autophagy down Homo sapiens prediction 9606 5728 10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|TEP1 HGNC:9588|MIM:601728|HPRD:03431 10 10q23.3 phosphatase and tensin homolog protein-coding phosphatase and tensin homolog hsa-miR-590-5p predicted by miR-21 (Rattus norvegicus), and PTEN predicted by Pten (Rattus norvegicus) according to Pubmed ID (25689721) 3707 hsa-miR-4262 miR-181abcd/4262 MIMAT0016894 miRNA UVRAG autophagy down Homo sapiens prediction 9606 7405 DHTX|VPS38|p63 HGNC:12640|MIM:602493|HPRD:03929 11 11q13.5 UV radiation resistance associated protein-coding UV radiation resistance associated hsa-miR-4262 predicted by miR-181a (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22356768) 3708 hsa-let-7f let-7/98/4458/4500 MIMAT0000067 miRNA IGF1R autophagy down Homo sapiens prediction 9606 3480 CD221|IGFIR|IGFR|JTK13 HGNC:5465|MIM:147370|Ensembl:ENSG00000140443|HPRD:00932|Vega:OTTHUMG00000149851 15 15q26.3 insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor hsa-let-7f predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 3709 hsa-miR-449b miR-34ac/34bc-5p/449abc/449c-5p MIMAT0003327 miRNA ATG4B autophagy down Homo sapiens prediction 9606 23192 APG4B|AUTL1 HGNC:20790|MIM:611338|Ensembl:ENSG00000168397|HPRD:16499|Vega:OTTHUMG00000151514 2 2q37.3 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase hsa-miR-449b predicted by miR-34a (Homo sapiens), and ATG4B predicted by ATG4B (Homo sapiens) according to Pubmed ID (24755409) 3710 hsa-miR-98 let-7/98/4458/4500 MIMAT0000096 miRNA ATG4B autophagy down Homo sapiens prediction 9606 23192 APG4B|AUTL1 HGNC:20790|MIM:611338|Ensembl:ENSG00000168397|HPRD:16499|Vega:OTTHUMG00000151514 2 2q37.3 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase hsa-miR-98 predicted by let-7b (Homo sapiens), and ATG4B predicted by ATG4B (Homo sapiens) according to Pubmed ID (22135297) 3711 hsa-miR-301b miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0004958 miRNA ATG2B autophagy down Homo sapiens prediction 9606 55102 C14orf103 HGNC:20187|Ensembl:ENSG00000066739|HPRD:12626|Vega:OTTHUMG00000149933 14 14q32.2 autophagy related 2B protein-coding autophagy related 2B hsa-miR-301b predicted by miR-130a (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (22902544) 3712 hsa-miR-4770 miR-143/1721/4770 MIMAT0019924 miRNA ATG2B autophagy down Homo sapiens prediction 9606 55102 C14orf103 HGNC:20187|Ensembl:ENSG00000066739|HPRD:12626|Vega:OTTHUMG00000149933 14 14q32.2 autophagy related 2B protein-coding autophagy related 2B hsa-miR-4770 predicted by miR-143 (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (25322940) 3713 hsa-miR-302c miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0000717 miRNA ULK1 autophagy down Homo sapiens prediction 9606 8408 ATG1|ATG1A|UNC51|Unc51.1|hATG1 HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|Vega:OTTHUMG00000168052 12 12q24.3 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 hsa-miR-302c predicted by miR-291 (Mus musculus), and ULK1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 3714 hsa-miR-30c miR-30abcdef/30abe-5p/384-5p MIMAT0000244 miRNA BECN1 autophagy down Homo sapiens prediction 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related hsa-miR-30c predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and BECN1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 3715 hsa-let-7d let-7/98/4458/4500 MIMAT0000065 miRNA IGF1R autophagy down Homo sapiens prediction 9606 3480 CD221|IGFIR|IGFR|JTK13 HGNC:5465|MIM:147370|Ensembl:ENSG00000140443|HPRD:00932|Vega:OTTHUMG00000149851 15 15q26.3 insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor hsa-let-7d predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 3716 hsa-miR-454 miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0003885 miRNA RB1CC1 autophagy down Homo sapiens prediction 9606 9821 ATG17|CC1|FIP200|PPP1R131 HGNC:15574|MIM:606837|Ensembl:ENSG00000023287|HPRD:06019|Vega:OTTHUMG00000164268 8 8q11 RB1-inducible coiled-coil 1 protein-coding RB1-inducible coiled-coil 1 hsa-miR-454 predicted by miR-133b (Homo sapiens), and RB1CC1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 3717 hsa-let-7d let-7/98/4458/4500 MIMAT0000065 miRNA ATG4B autophagy down Homo sapiens prediction 9606 23192 APG4B|AUTL1 HGNC:20790|MIM:611338|Ensembl:ENSG00000168397|HPRD:16499|Vega:OTTHUMG00000151514 2 2q37.3 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase hsa-let-7d predicted by let-7b (Homo sapiens), and ATG4B predicted by ATG4B (Homo sapiens) according to Pubmed ID (22135297) 3718 hsa-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000075 miRNA BECN1 autophagy down Homo sapiens prediction 9606 8678 ATG6|VPS30|beclin1 HGNC:1034|MIM:604378|Ensembl:ENSG00000126581|HPRD:05087|Vega:OTTHUMG00000180653 17 17q21 beclin 1, autophagy related protein-coding beclin 1, autophagy related hsa-miR-20a predicted by miR-17-5p (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (24755562),(25435430),(25485521) 3719 hsa-miR-302b miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0000715 miRNA ATG7 autophagy down Homo sapiens prediction 9606 10533 APG7-LIKE|APG7L|GSA7 HGNC:16935|MIM:608760|Ensembl:ENSG00000197548|HPRD:12293|Vega:OTTHUMG00000129740 3 3p25.3 autophagy related 7 protein-coding autophagy related 7 hsa-miR-302b predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 3720 hsa-miR-520e miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0002825 miRNA FYCO1 autophagy down Homo sapiens prediction 9606 79443 CATC2|CTRCT18|RUFY3|ZFYVE7 HGNC:14673|MIM:607182|Ensembl:ENSG00000163820|HPRD:06215|Vega:OTTHUMG00000133447 3 3p21.31 FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 hsa-miR-520e predicted by miR-373 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3721 hsa-miR-30a miR-30abcdef/30abe-5p/384-5p MIMAT0000087 miRNA ATG5 autophagy down Homo sapiens prediction 9606 9474 APG5|APG5-LIKE|APG5L|ASP|hAPG5 HGNC:589|MIM:604261|Ensembl:ENSG00000057663|HPRD:16051|Vega:OTTHUMG00000016193 6 6q21 autophagy related 5 protein-coding autophagy related 5 hsa-miR-30a predicted by mir-30d (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (23274497),(24148619) 3722 hsa-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0001413 miRNA HIF1A autophagy down Homo sapiens prediction 9606 3091 HIF-1A|HIF-1alpha|HIF1|HIF1-ALPHA|MOP1|PASD8|bHLHe78 HGNC:4910|MIM:603348|Ensembl:ENSG00000100644|HPRD:04517|Vega:OTTHUMG00000140344 14 14q23.2 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) hsa-miR-20b predicted by miR-20a (Homo sapiens), and HIF1A predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 3723 hsa-miR-30d miR-30abcdef/30abe-5p/384-5p MIMAT0000245 miRNA ATG12 autophagy down Homo sapiens prediction 9606 9140 APG12|APG12L|FBR93|HAPG12 HGNC:588|MIM:609608|Ensembl:ENSG00000145782|HPRD:08496|Vega:OTTHUMG00000128889 5 5q21-q22 autophagy related 12 protein-coding autophagy related 12 hsa-miR-30d predicted by miR-30b (Homo sapiens), and ATG12 predicted by ATG12 (Homo sapiens) according to Pubmed ID (22647547),(23274497) 3724 hsa-miR-30c miR-30abcdef/30abe-5p/384-5p MIMAT0000244 miRNA ATG2B autophagy down Homo sapiens prediction 9606 55102 C14orf103 HGNC:20187|Ensembl:ENSG00000066739|HPRD:12626|Vega:OTTHUMG00000149933 14 14q32.2 autophagy related 2B protein-coding autophagy related 2B hsa-miR-30c predicted by mir-30d (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (23274497) 3725 hsa-miR-367 miR-25/32/92abc/363/363-3p/367 MIMAT0000719 miRNA UVRAG autophagy down Homo sapiens prediction 9606 7405 DHTX|VPS38|p63 HGNC:12640|MIM:602493|HPRD:03929 11 11q13.5 UV radiation resistance associated protein-coding UV radiation resistance associated hsa-miR-367 predicted by miR-32 (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22135297) 3726 cfa-miR-29c miR-29abcd MIMAT0006705 miRNA ATG9A autophagy down Canis lupus familiaris prediction 9615 102154798 - Ensembl:ENSCAFG00000015071 37 - autophagy related 9A protein-coding - cfa-miR-29c predicted by miR-29b (Bos taurus), and ATG9A predicted by ATG9A (Bos taurus) according to Pubmed ID (25234643) 3727 cfa-miR-449 miR-34ac/34bc-5p/449abc/449c-5p MIMAT0001544 miRNA ATG4B autophagy down Canis lupus familiaris prediction 9615 609599 - - 25 - autophagy related 4B, cysteine peptidase protein-coding - cfa-miR-449 predicted by miR-34a (Homo sapiens), and ATG4B predicted by ATG4B (Homo sapiens) according to Pubmed ID (24755409) 3728 cfa-miR-98 let-7/98/4458/4500 MIMAT0006756 miRNA IGF1R autophagy down Canis lupus familiaris prediction 9615 442951 - - 3 - insulin-like growth factor 1 receptor protein-coding - cfa-miR-98 predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 3729 cfa-miR-16 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0006648 miRNA ATG7 autophagy down Canis lupus familiaris prediction 9615 476533 - - 20 - autophagy related 7 protein-coding - cfa-miR-16 predicted by miR-16 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23143396) 3730 cfa-miR-15b miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0006676 miRNA ATG14 autophagy down Canis lupus familiaris prediction 9615 490704 - Ensembl:ENSCAFG00000015046 8 - autophagy related 14 protein-coding - cfa-miR-15b predicted by miR-195 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 3731 cfa-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006695 miRNA ULK1 autophagy down Canis lupus familiaris prediction 9615 477437 - Ensembl:ENSCAFG00000006446 26 - unc-51 like autophagy activating kinase 1 protein-coding - cfa-miR-106b predicted by miR-106b (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 3732 cfa-miR-30d miR-30abcdef/30abe-5p/384-5p MIMAT0006616 miRNA BNIP3L autophagy down Canis lupus familiaris prediction 9615 608552 - - 25 - BCL2/adenovirus E1B 19kDa interacting protein 3-like protein-coding - cfa-miR-30d predicted by miR-30d (Homo sapiens), and BNIP3L predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 3733 cfa-miR-183 miR-183 MIMAT0006621 miRNA MAP1LC3B autophagy down Canis lupus familiaris prediction 9615 479619 - - 5 - microtubule-associated protein 1 light chain 3 beta protein-coding - cfa-miR-183 predicted by miR-183 (Homo sapiens), and MAP1LC3B predicted by MAP1LC3B (Homo sapiens) according to Pubmed ID (21622722) 3734 cfa-miR-137 miR-137/137ab MIMAT0006702 miRNA BNIP3L autophagy down Canis lupus familiaris prediction 9615 608552 - - 25 - BCL2/adenovirus E1B 19kDa interacting protein 3-like protein-coding - cfa-miR-137 predicted by miR-137 (Homo sapiens), and BNIP3L predicted by BNIP3L (Homo sapiens) according to Pubmed ID (24573672) 3735 cfa-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006695 miRNA ATG16L1 autophagy down Canis lupus familiaris prediction 9615 477412 - - 25 - autophagy related 16-like 1 (S. cerevisiae) protein-coding - cfa-miR-106b predicted by miR-106b (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 3736 cfa-miR-29b miR-29abcd MIMAT0006625 miRNA ATG14 autophagy down Canis lupus familiaris prediction 9615 490704 - Ensembl:ENSCAFG00000015046 8 - autophagy related 14 protein-coding - cfa-miR-29b predicted by miR-29b (Bos taurus), and ATG14 predicted by ATG14 (Bos taurus) according to Pubmed ID (25234643) 3737 cfa-miR-23b miR-23abc/23b-3p MIMAT0006612 miRNA ATG12 autophagy down Canis lupus familiaris prediction 9615 474636 - - 11 - autophagy related 12 protein-coding - cfa-miR-23b predicted by miR-23b (Homo sapiens), and ATG12 predicted by ATG12 (Homo sapiens) according to Pubmed ID (23916944),(24145177) 3738 cfa-let-7a let-7/98/4458/4500 MIMAT0006594 miRNA ATG7 autophagy down Canis lupus familiaris prediction 9615 476533 - - 20 - autophagy related 7 protein-coding - cfa-let-7a predicted by let-7a (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23143396) 3739 cfa-miR-30a miR-30abcdef/30abe-5p/384-5p MIMAT0006604 miRNA ATG2B autophagy down Canis lupus familiaris prediction 9615 480428 - Ensembl:ENSCAFG00000017729 8 - autophagy related 2B protein-coding - cfa-miR-30a predicted by mir-30d (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (23274497) 3740 cfa-miR-320 miR-320abcd/4429 MIMAT0006658 miRNA ULK1 autophagy down Canis lupus familiaris prediction 9615 477437 - Ensembl:ENSCAFG00000006446 26 - unc-51 like autophagy activating kinase 1 protein-coding - cfa-miR-320 predicted by miR-320a (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (23622248) 3741 cfa-miR-224 miR-224 MIMAT0006744 miRNA SMAD4 autophagy down Canis lupus familiaris prediction 9615 476196 MADH4 Ensembl:ENSCAFG00000000164 1 - SMAD family member 4 protein-coding - cfa-miR-224 predicted by miR-224 (Homo sapiens), and SMAD4 predicted by SMAD4 (Homo sapiens) according to Pubmed ID (23913306),(25068270) 3742 cfa-miR-301a miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0009853 miRNA RB1CC1 autophagy down Canis lupus familiaris prediction 9615 477876 - Ensembl:ENSCAFG00000006819 29 - RB1-inducible coiled-coil 1 protein-coding - cfa-miR-301a predicted by miR-133b (Homo sapiens), and RB1CC1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 3743 cfa-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0009830 miRNA ULK1 autophagy down Canis lupus familiaris prediction 9615 477437 - Ensembl:ENSCAFG00000006446 26 - unc-51 like autophagy activating kinase 1 protein-coding - cfa-miR-20b predicted by miR-106b (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 3744 cfa-miR-148b miR-148ab-3p/152 MIMAT0006663 miRNA ATG14 autophagy down Canis lupus familiaris prediction 9615 490704 - Ensembl:ENSCAFG00000015046 8 - autophagy related 14 protein-coding - cfa-miR-148b predicted by miR-152 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (25650716) 3745 cfa-miR-497 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0006691 miRNA BAG5 autophagy down Canis lupus familiaris prediction 9615 480444 - - 8 - BCL2-associated athanogene 5 protein-coding - cfa-miR-497 predicted by miR-16 (Mus musculus), and BAG5 predicted by Bag5 (Mus musculus) according to Pubmed ID (21770019) 3746 cfa-miR-497 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0006691 miRNA BCL2L2 autophagy down Canis lupus familiaris prediction 9615 490611 BCL-W Ensembl:ENSCAFG00000031094 8 - BCL2-like 2 protein-coding - cfa-miR-497 predicted by miR-15b (Mus musculus), and BCL2L2 predicted by Bcl2l2 (Mus musculus) according to Pubmed ID (21770019) 3747 cfa-miR-152 miR-148ab-3p/152 MIMAT0006738 miRNA ATG14 autophagy down Canis lupus familiaris prediction 9615 490704 - Ensembl:ENSCAFG00000015046 8 - autophagy related 14 protein-coding - cfa-miR-152 predicted by miR-152 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (25650716) 3748 cfa-miR-34b miR-34ac/34bc-5p/449abc/449c-5p MIMAT0009838 miRNA ATG9A autophagy down Canis lupus familiaris prediction 9615 102154798 - Ensembl:ENSCAFG00000015071 37 - autophagy related 9A protein-coding - cfa-miR-34b predicted by miR-34a (Homo sapiens),miR-34a (Rattus norvegicus), and ATG9A predicted by Atg9a (Rattus norvegicus),ATG9A (Homo sapiens) according to Pubmed ID (22902544),(24728149),(24973144) 3749 cfa-let-7b let-7/98/4458/4500 MIMAT0009836 miRNA OLR1 autophagy down Canis lupus familiaris prediction 9615 486694 - Ensembl:ENSCAFG00000013495 27 - oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding - cfa-let-7b predicted by let-7g (Mus musculus), and OLR1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 3750 cfa-miR-15b miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0006676 miRNA BAG5 autophagy down Canis lupus familiaris prediction 9615 480444 - - 8 - BCL2-associated athanogene 5 protein-coding - cfa-miR-15b predicted by miR-16 (Mus musculus), and BAG5 predicted by Bag5 (Mus musculus) according to Pubmed ID (21770019) 3751 cfa-miR-15a miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0006647 miRNA ATG7 autophagy down Canis lupus familiaris prediction 9615 476533 - - 20 - autophagy related 7 protein-coding - cfa-miR-15a predicted by miR-16 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23143396) 3752 cfa-miR-181c miR-181abcd/4262 MIMAT0006635 miRNA ATG16L1 autophagy down Canis lupus familiaris prediction 9615 477412 - - 25 - autophagy related 16-like 1 (S. cerevisiae) protein-coding - cfa-miR-181c predicted by miR-181a (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (22356768) 3753 cfa-miR-93 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006696 miRNA ATG16L1 autophagy down Canis lupus familiaris prediction 9615 477412 - - 25 - autophagy related 16-like 1 (S. cerevisiae) protein-coding - cfa-miR-93 predicted by miR-106b (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 3754 cfa-miR-1271 miR-96/507/1271 MIMAT0006685 miRNA MTOR autophagy down Canis lupus familiaris prediction 9615 478232 FRAP1 Ensembl:ENSCAFG00000016648 2 - mechanistic target of rapamycin (serine/threonine kinase) protein-coding - cfa-miR-1271 predicted by miR-96 (Homo sapiens), and MTOR predicted by MTOR (Homo sapiens) according to Pubmed ID (25333253) 3755 cfa-miR-7 miR-7/7ab MIMAT0006634 miRNA EGFR autophagy down Canis lupus familiaris prediction 9615 404306 - Ensembl:ENSCAFG00000003465 18 - epidermal growth factor receptor protein-coding - cfa-miR-7 predicted by miR-7 (Homo sapiens), and EGFR predicted by EGFR (Homo sapiens) according to Pubmed ID (22492316) 3756 cfa-miR-146a miR-146ac/146b-5p MIMAT0006684 miRNA NFKB1 autophagy down Canis lupus familiaris prediction 9615 442859 - Ensembl:ENSCAFG00000010730 32 - nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 protein-coding - cfa-miR-146a predicted by miR-146a (Mus musculus), and NFKB1 predicted by Nfkb1 (Mus musculus) according to Pubmed ID (23647548) 3757 cfa-miR-211 miR-204/204b/211 MIMAT0009867 miRNA VHL autophagy down Canis lupus familiaris prediction 9615 494000 - Ensembl:ENSCAFG00000005140 20 - von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase protein-coding - cfa-miR-211 predicted by miR-204 (Homo sapiens), and VHL predicted by VHL (Homo sapiens) according to Pubmed ID (25517751) 3758 cfa-miR-182 miR-182 MIMAT0009841 miRNA FOXO3 autophagy down Canis lupus familiaris prediction 9615 481954 FKHRL1|FOXO3A - 12 - forkhead box O3 protein-coding - cfa-miR-182 predicted by miR-182 (Homo sapiens), and FOXO3 predicted by FOXO3 (Homo sapiens) according to Pubmed ID (24871856) 3759 cfa-miR-195 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0006692 miRNA ATG14 autophagy down Canis lupus familiaris prediction 9615 490704 - Ensembl:ENSCAFG00000015046 8 - autophagy related 14 protein-coding - cfa-miR-195 predicted by miR-195 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 3760 cfa-let-7c let-7/98/4458/4500 MIMAT0006669 miRNA IGF1R autophagy down Canis lupus familiaris prediction 9615 442951 - - 3 - insulin-like growth factor 1 receptor protein-coding - cfa-let-7c predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 3761 cfa-miR-30a miR-30abcdef/30abe-5p/384-5p MIMAT0006604 miRNA ATG5 autophagy down Canis lupus familiaris prediction 9615 610868 - Ensembl:ENSCAFG00000003701 12 - autophagy related 5 protein-coding - cfa-miR-30a predicted by miR-30a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22395361),(22617440),(22902544),(23274497),(24148619) 3762 cfa-let-7j let-7/98/4458/4500 MIMAT0006763 miRNA ATG7 autophagy down Canis lupus familiaris prediction 9615 476533 - - 20 - autophagy related 7 protein-coding - cfa-let-7j predicted by let-7a (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23143396) 3763 cfa-let-7j let-7/98/4458/4500 MIMAT0006763 miRNA OLR1 autophagy down Canis lupus familiaris prediction 9615 486694 - Ensembl:ENSCAFG00000013495 27 - oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding - cfa-let-7j predicted by let-7g (Mus musculus), and OLR1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 3764 cfa-miR-30c miR-30abcdef/30abe-5p/384-5p MIMAT0006605 miRNA ATG5 autophagy down Canis lupus familiaris prediction 9615 610868 - Ensembl:ENSCAFG00000003701 12 - autophagy related 5 protein-coding - cfa-miR-30c predicted by miR-30a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22395361),(22617440),(22902544),(23274497),(24148619) 3765 cfa-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0009830 miRNA ATG16L1 autophagy down Canis lupus familiaris prediction 9615 477412 - - 25 - autophagy related 16-like 1 (S. cerevisiae) protein-coding - cfa-miR-20b predicted by miR-106b (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 3766 cfa-miR-155 miR-155 MIMAT0006671 miRNA GSK3B autophagy down Canis lupus familiaris prediction 9615 478575 - Ensembl:ENSCAFG00000011122 33 - glycogen synthase kinase 3 beta protein-coding - cfa-miR-155 predicted by miR-155 (Homo sapiens), and GSK3B predicted by GSK3B (Homo sapiens) according to Pubmed ID (24343269) 3767 cfa-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0009830 miRNA FYCO1 autophagy down Canis lupus familiaris prediction 9615 476649 - Ensembl:ENSCAFG00000013851 20 - FYVE and coiled-coil domain containing 1 protein-coding - cfa-miR-20b predicted by miR-93 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3768 cfa-miR-181c miR-181abcd/4262 MIMAT0006635 miRNA TP63 autophagy down Canis lupus familiaris prediction 9615 488125 TP73L Ensembl:ENSCAFG00000013961 34 - tumor protein p63 protein-coding - cfa-miR-181c predicted by miR-181a (Homo sapiens), and TP63 predicted by TP63 (Homo sapiens) according to Pubmed ID (22356768) 3769 cfa-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006695 miRNA BECN1 autophagy down Canis lupus familiaris prediction 9615 480513 - - 9 - beclin 1, autophagy related protein-coding - cfa-miR-106b predicted by miR-17-5p (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (24755562),(25435430),(25485521) 3770 cfa-miR-144 miR-144 MIMAT0006734 miRNA GSK3B autophagy down Canis lupus familiaris prediction 9615 478575 - Ensembl:ENSCAFG00000011122 33 - glycogen synthase kinase 3 beta protein-coding - cfa-miR-144 predicted by miR-144 (Homo sapiens), and GSK3B predicted by GSK3B (Homo sapiens) according to Pubmed ID (25060662) 3771 cfa-miR-146b miR-146ac/146b-5p MIMAT0006667 miRNA NFKB1 autophagy down Canis lupus familiaris prediction 9615 442859 - Ensembl:ENSCAFG00000010730 32 - nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 protein-coding - cfa-miR-146b predicted by miR-146a (Mus musculus), and NFKB1 predicted by Nfkb1 (Mus musculus) according to Pubmed ID (23647548) 3772 cfa-miR-130b miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0006659 miRNA ATG2B autophagy down Canis lupus familiaris prediction 9615 480428 - Ensembl:ENSCAFG00000017729 8 - autophagy related 2B protein-coding - cfa-miR-130b predicted by miR-130a (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (22902544) 3773 cfa-miR-181b miR-181abcd/4262 MIMAT0006708 miRNA ATG16L1 autophagy down Canis lupus familiaris prediction 9615 477412 - - 25 - autophagy related 16-like 1 (S. cerevisiae) protein-coding - cfa-miR-181b predicted by miR-181a (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (22356768) 3774 cfa-miR-181d miR-181abcd/4262 MIMAT0006636 miRNA ATG5 autophagy down Canis lupus familiaris prediction 9615 610868 - Ensembl:ENSCAFG00000003701 12 - autophagy related 5 protein-coding - cfa-miR-181d predicted by miR-181a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22356768),(22902544),(23322078) 3775 cfa-miR-98 let-7/98/4458/4500 MIMAT0006756 miRNA MTOR autophagy down Canis lupus familiaris prediction 9615 478232 FRAP1 Ensembl:ENSCAFG00000016648 2 - mechanistic target of rapamycin (serine/threonine kinase) protein-coding - cfa-miR-98 predicted by let-7 (Homo sapiens), and MTOR predicted by MTOR (Homo sapiens) according to Pubmed ID (25295787) 3776 cfa-miR-30c miR-30abcdef/30abe-5p/384-5p MIMAT0006605 miRNA ATG12 autophagy down Canis lupus familiaris prediction 9615 474636 - - 11 - autophagy related 12 protein-coding - cfa-miR-30c predicted by miR-30b (Homo sapiens), and ATG12 predicted by ATG12 (Homo sapiens) according to Pubmed ID (22647547),(23274497) 3777 cfa-miR-301b miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0009854 miRNA RB1CC1 autophagy down Canis lupus familiaris prediction 9615 477876 - Ensembl:ENSCAFG00000006819 29 - RB1-inducible coiled-coil 1 protein-coding - cfa-miR-301b predicted by miR-133b (Homo sapiens), and RB1CC1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 3778 cfa-miR-204 miR-204/204b/211 MIMAT0006598 miRNA VHL autophagy down Canis lupus familiaris prediction 9615 494000 - Ensembl:ENSCAFG00000005140 20 - von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase protein-coding - cfa-miR-204 predicted by miR-204 (Homo sapiens), and VHL predicted by VHL (Homo sapiens) according to Pubmed ID (25517751) 3779 cfa-miR-29a miR-29abcd MIMAT0006626 miRNA ATG9A autophagy down Canis lupus familiaris prediction 9615 102154798 - Ensembl:ENSCAFG00000015071 37 - autophagy related 9A protein-coding - cfa-miR-29a predicted by miR-29b (Bos taurus), and ATG9A predicted by ATG9A (Bos taurus) according to Pubmed ID (25234643) 3780 cfa-miR-1271 miR-96/507/1271 MIMAT0006685 miRNA ATG7 autophagy down Canis lupus familiaris prediction 9615 476533 - - 20 - autophagy related 7 protein-coding - cfa-miR-1271 predicted by miR-96 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (25333253) 3781 cfa-miR-221 miR-221/222/222ab/1928 MIMAT0006757 miRNA CDKN1B autophagy down Canis lupus familiaris prediction 9615 403429 Kip1|p27 - 27 - cyclin-dependent kinase inhibitor 1B (p27, Kip1) protein-coding - cfa-miR-221 predicted by miR-221 (Homo sapiens), and CDKN1B predicted by CDKN1B (Homo sapiens) according to Pubmed ID (25394488) 3782 cfa-miR-181d miR-181abcd/4262 MIMAT0006636 miRNA ATG16L1 autophagy down Canis lupus familiaris prediction 9615 477412 - - 25 - autophagy related 16-like 1 (S. cerevisiae) protein-coding - cfa-miR-181d predicted by miR-181a (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (22356768) 3783 cfa-miR-195 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0006692 miRNA ATG7 autophagy down Canis lupus familiaris prediction 9615 476533 - - 20 - autophagy related 7 protein-coding - cfa-miR-195 predicted by miR-16 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23143396) 3784 cfa-miR-222 miR-221/222/222ab/1928 MIMAT0009851 miRNA CDKN1B autophagy down Canis lupus familiaris prediction 9615 403429 Kip1|p27 - 27 - cyclin-dependent kinase inhibitor 1B (p27, Kip1) protein-coding - cfa-miR-222 predicted by miR-221 (Homo sapiens), and CDKN1B predicted by CDKN1B (Homo sapiens) according to Pubmed ID (25394488) 3785 cfa-miR-34c miR-34ac/34bc-5p/449abc/449c-5p MIMAT0006693 miRNA ATG4B autophagy down Canis lupus familiaris prediction 9615 609599 - - 25 - autophagy related 4B, cysteine peptidase protein-coding - cfa-miR-34c predicted by miR-34a (Homo sapiens), and ATG4B predicted by ATG4B (Homo sapiens) according to Pubmed ID (24755409) 3786 cfa-miR-181a miR-181abcd/4262 MIMAT0006707 miRNA ATG5 autophagy down Canis lupus familiaris prediction 9615 610868 - Ensembl:ENSCAFG00000003701 12 - autophagy related 5 protein-coding - cfa-miR-181a predicted by miR-181a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22356768),(22902544),(23322078) 3787 cfa-miR-155 miR-155 MIMAT0006671 miRNA ATG3 autophagy down Canis lupus familiaris prediction 9615 478564 - Ensembl:ENSCAFG00000010493 33 - autophagy related 3 protein-coding - cfa-miR-155 predicted by miR-155 (Homo sapiens), and ATG3 predicted by ATG3 (Homo sapiens) according to Pubmed ID (22135297) 3788 cfa-miR-30b miR-30abcdef/30abe-5p/384-5p MIMAT0006617 miRNA BNIP3L autophagy down Canis lupus familiaris prediction 9615 608552 - - 25 - BCL2/adenovirus E1B 19kDa interacting protein 3-like protein-coding - cfa-miR-30b predicted by miR-30d (Homo sapiens), and BNIP3L predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 3789 cfa-let-7j let-7/98/4458/4500 MIMAT0006763 miRNA IGF1R autophagy down Canis lupus familiaris prediction 9615 442951 - - 3 - insulin-like growth factor 1 receptor protein-coding - cfa-let-7j predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 3790 cfa-miR-181c miR-181abcd/4262 MIMAT0006635 miRNA ATG5 autophagy down Canis lupus familiaris prediction 9615 610868 - Ensembl:ENSCAFG00000003701 12 - autophagy related 5 protein-coding - cfa-miR-181c predicted by miR-181a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22356768),(22902544),(23322078) 3791 cfa-let-7e let-7/98/4458/4500 MIMAT0006608 miRNA ATG7 autophagy down Canis lupus familiaris prediction 9615 476533 - - 20 - autophagy related 7 protein-coding - cfa-let-7e predicted by let-7a (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23143396) 3792 cfa-miR-29b miR-29abcd MIMAT0006625 miRNA PSME4 autophagy down Canis lupus familiaris prediction 9615 474594 - Ensembl:ENSCAFG00000002729 10 - proteasome (prosome, macropain) activator subunit 4 protein-coding - cfa-miR-29b predicted by miR-29b (Homo sapiens), and PSME4 predicted by PSME4 (Homo sapiens) according to Pubmed ID (25234165) 3793 cfa-miR-25 miR-25/32/92abc/363/363-3p/367 MIMAT0006697 miRNA ULK1 autophagy down Canis lupus familiaris prediction 9615 477437 - Ensembl:ENSCAFG00000006446 26 - unc-51 like autophagy activating kinase 1 protein-coding - cfa-miR-25 predicted by miR-25 (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (25026296) 3794 cfa-miR-92a miR-25/32/92abc/363/363-3p/367 MIMAT0006653 miRNA ULK1 autophagy down Canis lupus familiaris prediction 9615 477437 - Ensembl:ENSCAFG00000006446 26 - unc-51 like autophagy activating kinase 1 protein-coding - cfa-miR-92a predicted by miR-25 (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (25026296) 3795 cfa-miR-16 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0006648 miRNA ATG5 autophagy down Canis lupus familiaris prediction 9615 610868 - Ensembl:ENSCAFG00000003701 12 - autophagy related 5 protein-coding - cfa-miR-16 predicted by miR-16 (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (23143396) 3796 cfa-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006651 miRNA ATG5 autophagy down Canis lupus familiaris prediction 9615 610868 - Ensembl:ENSCAFG00000003701 12 - autophagy related 5 protein-coding - cfa-miR-20a predicted by miR-20a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (25485521) 3797 cfa-miR-181a miR-181abcd/4262 MIMAT0006707 miRNA TP63 autophagy down Canis lupus familiaris prediction 9615 488125 TP73L Ensembl:ENSCAFG00000013961 34 - tumor protein p63 protein-coding - cfa-miR-181a predicted by miR-181a (Homo sapiens), and TP63 predicted by TP63 (Homo sapiens) according to Pubmed ID (22356768) 3798 cfa-miR-31 miR-31 MIMAT0006599 miRNA GSK3B autophagy down Canis lupus familiaris prediction 9615 478575 - Ensembl:ENSCAFG00000011122 33 - glycogen synthase kinase 3 beta protein-coding - cfa-miR-31 predicted by miR-31 (Homo sapiens), and GSK3B predicted by GSK3B (Homo sapiens) according to Pubmed ID (24343269) 3799 cfa-miR-375 miR-375 MIMAT0009871 miRNA RB1CC1 autophagy down Canis lupus familiaris prediction 9615 477876 - Ensembl:ENSCAFG00000006819 29 - RB1-inducible coiled-coil 1 protein-coding - cfa-miR-375 predicted by miR-375 (Homo sapiens), and RB1CC1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (22135297) 3800 cfa-miR-101 miR-101/101ab MIMAT0006600 miRNA ATG4D autophagy down Canis lupus familiaris prediction 9615 484953 - Ensembl:ENSCAFG00000017776 20 - autophagy related 4D, cysteine peptidase protein-coding - cfa-miR-101 predicted by miR-101 (Homo sapiens), and ATG4D predicted by (Homo sapiens),ATG4D (Homo sapiens) according to Pubmed ID (21915098),(22085996),(22902544),(23483142) 3801 cfa-miR-454 miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0009927 miRNA ATG2B autophagy down Canis lupus familiaris prediction 9615 480428 - Ensembl:ENSCAFG00000017729 8 - autophagy related 2B protein-coding - cfa-miR-454 predicted by miR-130a (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (22902544) 3802 cfa-miR-301a miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0009853 miRNA ATG2B autophagy down Canis lupus familiaris prediction 9615 480428 - Ensembl:ENSCAFG00000017729 8 - autophagy related 2B protein-coding - cfa-miR-301a predicted by miR-130a (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (22902544) 3803 cfa-let-7g let-7/98/4458/4500 MIMAT0006637 miRNA OLR1 autophagy down Canis lupus familiaris prediction 9615 486694 - Ensembl:ENSCAFG00000013495 27 - oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding - cfa-let-7g predicted by let-7g (Mus musculus), and OLR1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 3804 cfa-miR-30b miR-30abcdef/30abe-5p/384-5p MIMAT0006617 miRNA ATG12 autophagy down Canis lupus familiaris prediction 9615 474636 - - 11 - autophagy related 12 protein-coding - cfa-miR-30b predicted by miR-30b (Homo sapiens), and ATG12 predicted by ATG12 (Homo sapiens) according to Pubmed ID (22647547),(23274497) 3805 cfa-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006651 miRNA ULK1 autophagy down Canis lupus familiaris prediction 9615 477437 - Ensembl:ENSCAFG00000006446 26 - unc-51 like autophagy activating kinase 1 protein-coding - cfa-miR-20a predicted by miR-106b (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 3806 cfa-miR-143 miR-143/1721/4770 MIMAT0006682 miRNA ATG2B autophagy down Canis lupus familiaris prediction 9615 480428 - Ensembl:ENSCAFG00000017729 8 - autophagy related 2B protein-coding - cfa-miR-143 predicted by miR-143 (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (25322940) 3807 cfa-miR-98 let-7/98/4458/4500 MIMAT0006756 miRNA OLR1 autophagy down Canis lupus familiaris prediction 9615 486694 - Ensembl:ENSCAFG00000013495 27 - oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding - cfa-miR-98 predicted by let-7g (Mus musculus), and OLR1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 3808 cfa-miR-15b miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0006676 miRNA ATG7 autophagy down Canis lupus familiaris prediction 9615 476533 - - 20 - autophagy related 7 protein-coding - cfa-miR-15b predicted by miR-16 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23143396) 3809 cfa-let-7f let-7/98/4458/4500 MIMAT0006610 miRNA IGF1R autophagy down Canis lupus familiaris prediction 9615 442951 - - 3 - insulin-like growth factor 1 receptor protein-coding - cfa-let-7f predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 3810 cfa-let-7a let-7/98/4458/4500 MIMAT0006594 miRNA IGF1R autophagy down Canis lupus familiaris prediction 9615 442951 - - 3 - insulin-like growth factor 1 receptor protein-coding - cfa-let-7a predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 3811 cfa-miR-30a miR-30abcdef/30abe-5p/384-5p MIMAT0006604 miRNA BNIP3L autophagy down Canis lupus familiaris prediction 9615 608552 - - 25 - BCL2/adenovirus E1B 19kDa interacting protein 3-like protein-coding - cfa-miR-30a predicted by miR-30d (Homo sapiens), and BNIP3L predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 3812 cfa-miR-99a miR-99ab/100 MIMAT0006668 miRNA IGF1R autophagy down Canis lupus familiaris prediction 9615 442951 - - 3 - insulin-like growth factor 1 receptor protein-coding - cfa-miR-99a predicted by miR-100 (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25026290) 3813 cfa-miR-29c miR-29abcd MIMAT0006705 miRNA ATG14 autophagy down Canis lupus familiaris prediction 9615 490704 - Ensembl:ENSCAFG00000015046 8 - autophagy related 14 protein-coding - cfa-miR-29c predicted by miR-29b (Bos taurus), and ATG14 predicted by ATG14 (Bos taurus) according to Pubmed ID (25234643) 3814 cfa-miR-30b miR-30abcdef/30abe-5p/384-5p MIMAT0006617 miRNA ATG2B autophagy down Canis lupus familiaris prediction 9615 480428 - Ensembl:ENSCAFG00000017729 8 - autophagy related 2B protein-coding - cfa-miR-30b predicted by mir-30d (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (23274497) 3815 cfa-miR-211 miR-204/204b/211 MIMAT0009867 miRNA MAP1LC3B autophagy down Canis lupus familiaris prediction 9615 479619 - - 5 - microtubule-associated protein 1 light chain 3 beta protein-coding - cfa-miR-211 predicted by miR-204 (Homo sapiens),miR-204 (Rattus norvegicus), and MAP1LC3B predicted by Map1lc3b (Rattus norvegicus),MAP1LC3B (Homo sapiens) according to Pubmed ID (21316776),(21631941),(22516261),(25209181),(25517751) 3816 cfa-miR-101 miR-101/101ab MIMAT0006600 miRNA EZH2 autophagy down Canis lupus familiaris prediction 9615 475511 - Ensembl:ENSCAFG00000003411 16 - enhancer of zeste homolog 2 (Drosophila) protein-coding - cfa-miR-101 predicted by miR-101 (Homo sapiens), and EZH2 predicted by EZH2 (Homo sapiens) according to Pubmed ID (24211739) 3817 cfa-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006695 miRNA FYCO1 autophagy down Canis lupus familiaris prediction 9615 476649 - Ensembl:ENSCAFG00000013851 20 - FYVE and coiled-coil domain containing 1 protein-coding - cfa-miR-106b predicted by miR-93 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3818 cfa-miR-374a miR-374ab MIMAT0006753 miRNA TP63 autophagy down Canis lupus familiaris prediction 9615 488125 TP73L Ensembl:ENSCAFG00000013961 34 - tumor protein p63 protein-coding - cfa-miR-374a predicted by miR-374a (Homo sapiens), and TP63 predicted by TP63 (Homo sapiens) according to Pubmed ID (22356768) 3819 cfa-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006651 miRNA FYCO1 autophagy down Canis lupus familiaris prediction 9615 476649 - Ensembl:ENSCAFG00000013851 20 - FYVE and coiled-coil domain containing 1 protein-coding - cfa-miR-20a predicted by miR-93 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3820 cfa-miR-99b miR-99ab/100 MIMAT0006607 miRNA MTOR autophagy down Canis lupus familiaris prediction 9615 478232 FRAP1 Ensembl:ENSCAFG00000016648 2 - mechanistic target of rapamycin (serine/threonine kinase) protein-coding - cfa-miR-99b predicted by miR-100 (Homo sapiens), and MTOR predicted by MTOR (Homo sapiens) according to Pubmed ID (25026290) 3821 cfa-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006695 miRNA HIF1A autophagy down Canis lupus familiaris prediction 9615 480348 - Ensembl:ENSCAFG00000015718 8 - hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding - cfa-miR-106b predicted by miR-20a (Homo sapiens), and HIF1A predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 3822 cfa-miR-195 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0006692 miRNA BAG5 autophagy down Canis lupus familiaris prediction 9615 480444 - - 8 - BCL2-associated athanogene 5 protein-coding - cfa-miR-195 predicted by miR-16 (Mus musculus), and BAG5 predicted by Bag5 (Mus musculus) according to Pubmed ID (21770019) 3823 cfa-miR-204 miR-204/204b/211 MIMAT0006598 miRNA CAV1 autophagy down Canis lupus familiaris prediction 9615 403980 caveolin 1 Ensembl:ENSCAFG00000003404 14 - caveolin 1, caveolae protein, 22kDa protein-coding - cfa-miR-204 predicted by miR-204 (Homo sapiens), and CAV1 predicted by CAV1 (Homo sapiens) according to Pubmed ID (25517751) 3824 cfa-miR-101 miR-101/101ab MIMAT0006600 miRNA STMN1 autophagy down Canis lupus familiaris prediction 9615 478175 - - 2 - stathmin 1 protein-coding - cfa-miR-101 predicted by miR-101 (Homo sapiens), and STMN1 predicted by STMN1 (Homo sapiens) according to Pubmed ID (21915098),(23483142),(25607713) 3825 cfa-miR-30d miR-30abcdef/30abe-5p/384-5p MIMAT0006616 miRNA ATG12 autophagy down Canis lupus familiaris prediction 9615 474636 - - 11 - autophagy related 12 protein-coding - cfa-miR-30d predicted by miR-30b (Homo sapiens), and ATG12 predicted by ATG12 (Homo sapiens) according to Pubmed ID (22647547),(23274497) 3826 cfa-miR-34a miR-34ac/34bc-5p/449abc/449c-5p MIMAT0006690 miRNA ATG9A autophagy down Canis lupus familiaris prediction 9615 102154798 - Ensembl:ENSCAFG00000015071 37 - autophagy related 9A protein-coding - cfa-miR-34a predicted by miR-34a (Homo sapiens),miR-34a (Rattus norvegicus), and ATG9A predicted by Atg9a (Rattus norvegicus),ATG9A (Homo sapiens) according to Pubmed ID (22902544),(24728149),(24973144) 3827 cfa-miR-93 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006696 miRNA ULK1 autophagy down Canis lupus familiaris prediction 9615 477437 - Ensembl:ENSCAFG00000006446 26 - unc-51 like autophagy activating kinase 1 protein-coding - cfa-miR-93 predicted by miR-106b (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 3828 cfa-let-7b let-7/98/4458/4500 MIMAT0009836 miRNA MTOR autophagy down Canis lupus familiaris prediction 9615 478232 FRAP1 Ensembl:ENSCAFG00000016648 2 - mechanistic target of rapamycin (serine/threonine kinase) protein-coding - cfa-let-7b predicted by let-7 (Homo sapiens), and MTOR predicted by MTOR (Homo sapiens) according to Pubmed ID (25295787) 3829 cfa-miR-181d miR-181abcd/4262 MIMAT0006636 miRNA TP63 autophagy down Canis lupus familiaris prediction 9615 488125 TP73L Ensembl:ENSCAFG00000013961 34 - tumor protein p63 protein-coding - cfa-miR-181d predicted by miR-181a (Homo sapiens), and TP63 predicted by TP63 (Homo sapiens) according to Pubmed ID (22356768) 3830 cfa-miR-92b miR-25/32/92abc/363/363-3p/367 MIMAT0006703 miRNA ULK1 autophagy down Canis lupus familiaris prediction 9615 477437 - Ensembl:ENSCAFG00000006446 26 - unc-51 like autophagy activating kinase 1 protein-coding - cfa-miR-92b predicted by miR-25 (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (25026296) 3831 cfa-miR-30b miR-30abcdef/30abe-5p/384-5p MIMAT0006617 miRNA ATG5 autophagy down Canis lupus familiaris prediction 9615 610868 - Ensembl:ENSCAFG00000003701 12 - autophagy related 5 protein-coding - cfa-miR-30b predicted by miR-30a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22395361),(22617440),(22902544),(23274497),(24148619) 3832 cfa-let-7f let-7/98/4458/4500 MIMAT0006610 miRNA MTOR autophagy down Canis lupus familiaris prediction 9615 478232 FRAP1 Ensembl:ENSCAFG00000016648 2 - mechanistic target of rapamycin (serine/threonine kinase) protein-coding - cfa-let-7f predicted by let-7 (Homo sapiens), and MTOR predicted by MTOR (Homo sapiens) according to Pubmed ID (25295787) 3833 cfa-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006651 miRNA BECN1 autophagy down Canis lupus familiaris prediction 9615 480513 - - 9 - beclin 1, autophagy related protein-coding - cfa-miR-20a predicted by miR-17-5p (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (24755562),(25435430),(25485521) 3834 cfa-miR-99b miR-99ab/100 MIMAT0006607 miRNA IGF1R autophagy down Canis lupus familiaris prediction 9615 442951 - - 3 - insulin-like growth factor 1 receptor protein-coding - cfa-miR-99b predicted by miR-100 (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25026290) 3835 cfa-miR-130b miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0006659 miRNA RB1CC1 autophagy down Canis lupus familiaris prediction 9615 477876 - Ensembl:ENSCAFG00000006819 29 - RB1-inducible coiled-coil 1 protein-coding - cfa-miR-130b predicted by miR-133b (Homo sapiens), and RB1CC1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 3836 cfa-miR-215 miR-192/215 MIMAT0009848 miRNA MAP1LC3B autophagy down Canis lupus familiaris prediction 9615 479619 - - 5 - microtubule-associated protein 1 light chain 3 beta protein-coding - cfa-miR-215 predicted by miR-192 (Homo sapiens), and MAP1LC3B predicted by MAP1LC3B (Homo sapiens) according to Pubmed ID (22135297) 3837 cfa-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006695 miRNA ATG7 autophagy down Canis lupus familiaris prediction 9615 476533 - - 20 - autophagy related 7 protein-coding - cfa-miR-106b predicted by miR-17 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 3838 cfa-let-7j let-7/98/4458/4500 MIMAT0006763 miRNA MTOR autophagy down Canis lupus familiaris prediction 9615 478232 FRAP1 Ensembl:ENSCAFG00000016648 2 - mechanistic target of rapamycin (serine/threonine kinase) protein-coding - cfa-let-7j predicted by let-7 (Homo sapiens), and MTOR predicted by MTOR (Homo sapiens) according to Pubmed ID (25295787) 3839 cfa-miR-16 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0006648 miRNA BCL2L2 autophagy down Canis lupus familiaris prediction 9615 490611 BCL-W Ensembl:ENSCAFG00000031094 8 - BCL2-like 2 protein-coding - cfa-miR-16 predicted by miR-15b (Mus musculus), and BCL2L2 predicted by Bcl2l2 (Mus musculus) according to Pubmed ID (21770019) 3840 cfa-miR-30d miR-30abcdef/30abe-5p/384-5p MIMAT0006616 miRNA BECN1 autophagy down Canis lupus familiaris prediction 9615 480513 - - 9 - beclin 1, autophagy related protein-coding - cfa-miR-30d predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and BECN1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 3841 cfa-miR-29c miR-29abcd MIMAT0006705 miRNA PSME4 autophagy down Canis lupus familiaris prediction 9615 474594 - Ensembl:ENSCAFG00000002729 10 - proteasome (prosome, macropain) activator subunit 4 protein-coding - cfa-miR-29c predicted by miR-29b (Homo sapiens), and PSME4 predicted by PSME4 (Homo sapiens) according to Pubmed ID (25234165) 3842 cfa-miR-30d miR-30abcdef/30abe-5p/384-5p MIMAT0006616 miRNA ATG2B autophagy down Canis lupus familiaris prediction 9615 480428 - Ensembl:ENSCAFG00000017729 8 - autophagy related 2B protein-coding - cfa-miR-30d predicted by mir-30d (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (23274497) 3843 cfa-miR-96 miR-96/507/1271 MIMAT0009861 miRNA MTOR autophagy down Canis lupus familiaris prediction 9615 478232 FRAP1 Ensembl:ENSCAFG00000016648 2 - mechanistic target of rapamycin (serine/threonine kinase) protein-coding - cfa-miR-96 predicted by miR-96 (Homo sapiens), and MTOR predicted by MTOR (Homo sapiens) according to Pubmed ID (25333253) 3844 cfa-let-7b let-7/98/4458/4500 MIMAT0009836 miRNA IGF1R autophagy down Canis lupus familiaris prediction 9615 442951 - - 3 - insulin-like growth factor 1 receptor protein-coding - cfa-let-7b predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 3845 cfa-let-7c let-7/98/4458/4500 MIMAT0006669 miRNA ATG7 autophagy down Canis lupus familiaris prediction 9615 476533 - - 20 - autophagy related 7 protein-coding - cfa-let-7c predicted by let-7a (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23143396) 3846 cfa-miR-34b miR-34ac/34bc-5p/449abc/449c-5p MIMAT0009838 miRNA ATG4B autophagy down Canis lupus familiaris prediction 9615 609599 - - 25 - autophagy related 4B, cysteine peptidase protein-coding - cfa-miR-34b predicted by miR-34a (Homo sapiens), and ATG4B predicted by ATG4B (Homo sapiens) according to Pubmed ID (24755409) 3847 cfa-miR-181a miR-181abcd/4262 MIMAT0006707 miRNA ATG16L1 autophagy down Canis lupus familiaris prediction 9615 477412 - - 25 - autophagy related 16-like 1 (S. cerevisiae) protein-coding - cfa-miR-181a predicted by miR-181a (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (22356768) 3848 cfa-miR-93 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006696 miRNA ATG7 autophagy down Canis lupus familiaris prediction 9615 476533 - - 20 - autophagy related 7 protein-coding - cfa-miR-93 predicted by miR-17 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 3849 cfa-miR-106a miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0006749 miRNA ULK1 autophagy down Canis lupus familiaris prediction 9615 477437 - Ensembl:ENSCAFG00000006446 26 - unc-51 like autophagy activating kinase 1 protein-coding - cfa-miR-106a predicted by miR-291 (Mus musculus), and ULK1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 3850 cfa-miR-301b miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0009854 miRNA ATG2B autophagy down Canis lupus familiaris prediction 9615 480428 - Ensembl:ENSCAFG00000017729 8 - autophagy related 2B protein-coding - cfa-miR-301b predicted by miR-130a (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (22902544) 3851 cfa-miR-363 miR-25/32/92abc/363/363-3p/367 MIMAT0006750 miRNA ULK1 autophagy down Canis lupus familiaris prediction 9615 477437 - Ensembl:ENSCAFG00000006446 26 - unc-51 like autophagy activating kinase 1 protein-coding - cfa-miR-363 predicted by miR-25 (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (25026296) 3852 cfa-miR-335 miR-335/335-5p MIMAT0006624 miRNA MAP1LC3B autophagy down Canis lupus familiaris prediction 9615 479619 - - 5 - microtubule-associated protein 1 light chain 3 beta protein-coding - cfa-miR-335 predicted by miR-335 (Homo sapiens), and MAP1LC3B predicted by MAP1LC3B (Homo sapiens) according to Pubmed ID (22135297) 3853 cfa-miR-374b miR-374ab MIMAT0006754 miRNA TP63 autophagy down Canis lupus familiaris prediction 9615 488125 TP73L Ensembl:ENSCAFG00000013961 34 - tumor protein p63 protein-coding - cfa-miR-374b predicted by miR-374a (Homo sapiens), and TP63 predicted by TP63 (Homo sapiens) according to Pubmed ID (22356768) 3854 cfa-miR-15b miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0006676 miRNA ATG5 autophagy down Canis lupus familiaris prediction 9615 610868 - Ensembl:ENSCAFG00000003701 12 - autophagy related 5 protein-coding - cfa-miR-15b predicted by miR-16 (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (23143396) 3855 cfa-miR-155 miR-155 MIMAT0006671 miRNA GABARAPL1 autophagy down Canis lupus familiaris prediction 9615 612919 - - 27 - GABA(A) receptor-associated protein like 1 protein-coding - cfa-miR-155 predicted by miR-155 (Homo sapiens), and GABARAPL1 predicted by GABARAPL1 (Homo sapiens) according to Pubmed ID (20584899) 3856 cfa-miR-451 miR-451 MIMAT0009870 miRNA TSC1 autophagy down Canis lupus familiaris prediction 9615 480688 - - 9 - tuberous sclerosis 1 protein-coding - cfa-miR-451 predicted by miR-451 (Homo sapiens), and TSC1 predicted by TSC1 (Homo sapiens) according to Pubmed ID (25209900) 3857 cfa-miR-216a miR-216a MIMAT0009849 miRNA BECN1 autophagy down Canis lupus familiaris prediction 9615 480513 - - 9 - beclin 1, autophagy related protein-coding - cfa-miR-216a predicted by miR-216a (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (24481443) 3858 cfa-miR-211 miR-204/204b/211 MIMAT0009867 miRNA CAV1 autophagy down Canis lupus familiaris prediction 9615 403980 caveolin 1 Ensembl:ENSCAFG00000003404 14 - caveolin 1, caveolae protein, 22kDa protein-coding - cfa-miR-211 predicted by miR-204 (Homo sapiens), and CAV1 predicted by CAV1 (Homo sapiens) according to Pubmed ID (25517751) 3859 cfa-let-7g let-7/98/4458/4500 MIMAT0006637 miRNA IGF1R autophagy down Canis lupus familiaris prediction 9615 442951 - - 3 - insulin-like growth factor 1 receptor protein-coding - cfa-let-7g predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 3860 cfa-miR-29a miR-29abcd MIMAT0006626 miRNA PSME4 autophagy down Canis lupus familiaris prediction 9615 474594 - Ensembl:ENSCAFG00000002729 10 - proteasome (prosome, macropain) activator subunit 4 protein-coding - cfa-miR-29a predicted by miR-29b (Homo sapiens), and PSME4 predicted by PSME4 (Homo sapiens) according to Pubmed ID (25234165) 3861 cfa-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0009830 miRNA HIF1A autophagy down Canis lupus familiaris prediction 9615 480348 - Ensembl:ENSCAFG00000015718 8 - hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding - cfa-miR-20b predicted by miR-20a (Homo sapiens), and HIF1A predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 3862 cfa-miR-15a miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0006647 miRNA ATG14 autophagy down Canis lupus familiaris prediction 9615 490704 - Ensembl:ENSCAFG00000015046 8 - autophagy related 14 protein-coding - cfa-miR-15a predicted by miR-195 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 3863 cfa-miR-497 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0006691 miRNA ATG14 autophagy down Canis lupus familiaris prediction 9615 490704 - Ensembl:ENSCAFG00000015046 8 - autophagy related 14 protein-coding - cfa-miR-497 predicted by miR-195 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 3864 cfa-miR-200c miR-200bc/429/548a MIMAT0006664 miRNA UBQLN1 autophagy down Canis lupus familiaris prediction 9615 476312 - - 1 - ubiquilin 1 protein-coding - cfa-miR-200c predicted by miR-200c (Homo sapiens), and UBQLN1 predicted by UBQLN1 (Homo sapiens) according to Pubmed ID (25044403) 3865 cfa-miR-182 miR-182 MIMAT0009841 miRNA BCL2 autophagy down Canis lupus familiaris prediction 9615 403416 BCL-2 - 1 - B-cell CLL/lymphoma 2 protein-coding - cfa-miR-182 predicted by miR-182 (Homo sapiens), and BCL2 predicted by BCL2 (Homo sapiens) according to Pubmed ID (23936432) 3866 cfa-miR-195 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0006692 miRNA ATG5 autophagy down Canis lupus familiaris prediction 9615 610868 - Ensembl:ENSCAFG00000003701 12 - autophagy related 5 protein-coding - cfa-miR-195 predicted by miR-16 (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (23143396) 3867 cfa-miR-130a miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0006631 miRNA RB1CC1 autophagy down Canis lupus familiaris prediction 9615 477876 - Ensembl:ENSCAFG00000006819 29 - RB1-inducible coiled-coil 1 protein-coding - cfa-miR-130a predicted by miR-133b (Homo sapiens), and RB1CC1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 3868 cfa-miR-454 miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0009927 miRNA RB1CC1 autophagy down Canis lupus familiaris prediction 9615 477876 - Ensembl:ENSCAFG00000006819 29 - RB1-inducible coiled-coil 1 protein-coding - cfa-miR-454 predicted by miR-133b (Homo sapiens), and RB1CC1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 3869 cfa-miR-144 miR-144 MIMAT0006734 miRNA MTOR autophagy down Canis lupus familiaris prediction 9615 478232 FRAP1 Ensembl:ENSCAFG00000016648 2 - mechanistic target of rapamycin (serine/threonine kinase) protein-coding - cfa-miR-144 predicted by miR-144 (Homo sapiens), and MTOR predicted by MTOR (Homo sapiens) according to Pubmed ID (25060662) 3870 cfa-miR-30b miR-30abcdef/30abe-5p/384-5p MIMAT0006617 miRNA BECN1 autophagy down Canis lupus familiaris prediction 9615 480513 - - 9 - beclin 1, autophagy related protein-coding - cfa-miR-30b predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and BECN1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 3871 cfa-miR-29b miR-29abcd MIMAT0006625 miRNA ATG9A autophagy down Canis lupus familiaris prediction 9615 102154798 - Ensembl:ENSCAFG00000015071 37 - autophagy related 9A protein-coding - cfa-miR-29b predicted by miR-29b (Bos taurus), and ATG9A predicted by ATG9A (Bos taurus) according to Pubmed ID (25234643) 3872 cfa-miR-30c miR-30abcdef/30abe-5p/384-5p MIMAT0006605 miRNA ATG2B autophagy down Canis lupus familiaris prediction 9615 480428 - Ensembl:ENSCAFG00000017729 8 - autophagy related 2B protein-coding - cfa-miR-30c predicted by mir-30d (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (23274497) 3873 cfa-miR-93 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006696 miRNA ATG5 autophagy down Canis lupus familiaris prediction 9615 610868 - Ensembl:ENSCAFG00000003701 12 - autophagy related 5 protein-coding - cfa-miR-93 predicted by miR-20a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (25485521) 3874 cfa-miR-96 miR-96/507/1271 MIMAT0009861 miRNA ATG7 autophagy down Canis lupus familiaris prediction 9615 476533 - - 20 - autophagy related 7 protein-coding - cfa-miR-96 predicted by miR-96 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (25333253) 3875 cfa-miR-30a miR-30abcdef/30abe-5p/384-5p MIMAT0006604 miRNA BECN1 autophagy down Canis lupus familiaris prediction 9615 480513 - - 9 - beclin 1, autophagy related protein-coding - cfa-miR-30a predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and BECN1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 3876 cfa-let-7f let-7/98/4458/4500 MIMAT0006610 miRNA OLR1 autophagy down Canis lupus familiaris prediction 9615 486694 - Ensembl:ENSCAFG00000013495 27 - oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding - cfa-let-7f predicted by let-7g (Mus musculus), and OLR1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 3877 cfa-miR-16 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0006648 miRNA BAG5 autophagy down Canis lupus familiaris prediction 9615 480444 - - 8 - BCL2-associated athanogene 5 protein-coding - cfa-miR-16 predicted by miR-16 (Mus musculus), and BAG5 predicted by Bag5 (Mus musculus) according to Pubmed ID (21770019) 3878 cfa-miR-24 miR-24/24ab/24-3p MIMAT0006614 miRNA ATG4A autophagy down Canis lupus familiaris prediction 9615 481015 - Ensembl:ENSCAFG00000018009 X - autophagy related 4A, cysteine peptidase protein-coding - cfa-miR-24 predicted by miR-24-3p (Homo sapiens), and ATG4A predicted by ATG4A (Homo sapiens) according to Pubmed ID (25426560) 3879 cfa-miR-181b miR-181abcd/4262 MIMAT0006708 miRNA ATG5 autophagy down Canis lupus familiaris prediction 9615 610868 - Ensembl:ENSCAFG00000003701 12 - autophagy related 5 protein-coding - cfa-miR-181b predicted by miR-181a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22356768),(22902544),(23322078) 3880 cfa-miR-31 miR-31 MIMAT0006599 miRNA PPP2R4 autophagy down Canis lupus familiaris prediction 9615 491303 - - 9 - protein phosphatase 2A activator, regulatory subunit 4 protein-coding - cfa-miR-31 predicted by miR-31 (Homo sapiens), and PPP2R4 predicted by PPP2R4 (Homo sapiens) according to Pubmed ID (24343269) 3881 cfa-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006651 miRNA ATG16L1 autophagy down Canis lupus familiaris prediction 9615 477412 - - 25 - autophagy related 16-like 1 (S. cerevisiae) protein-coding - cfa-miR-20a predicted by miR-106b (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 3882 cfa-let-7b let-7/98/4458/4500 MIMAT0009836 miRNA ATG7 autophagy down Canis lupus familiaris prediction 9615 476533 - - 20 - autophagy related 7 protein-coding - cfa-let-7b predicted by let-7a (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23143396) 3883 cfa-miR-106a miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0006749 miRNA ATG7 autophagy down Canis lupus familiaris prediction 9615 476533 - - 20 - autophagy related 7 protein-coding - cfa-miR-106a predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 3884 cfa-miR-101 miR-101/101ab MIMAT0006600 miRNA RAB5A autophagy down Canis lupus familiaris prediction 9615 404008 - Ensembl:ENSCAFG00000005814 23 - RAB5A, member RAS oncogene family protein-coding - cfa-miR-101 predicted by miR-101 (Homo sapiens), and RAB5A predicted by RAB5A (Homo sapiens) according to Pubmed ID (21915098),(23483142),(25606826) 3885 cfa-miR-204 miR-204/204b/211 MIMAT0006598 miRNA TRPM3 autophagy down Canis lupus familiaris prediction 9615 476326 - Ensembl:ENSCAFG00000001849 1 - transient receptor potential cation channel, subfamily M, member 3 protein-coding - cfa-miR-204 predicted by miR-204 (Homo sapiens), and TRPM3 predicted by TRPM3 (Homo sapiens) according to Pubmed ID (25517751) 3886 cfa-let-7e let-7/98/4458/4500 MIMAT0006608 miRNA MTOR autophagy down Canis lupus familiaris prediction 9615 478232 FRAP1 Ensembl:ENSCAFG00000016648 2 - mechanistic target of rapamycin (serine/threonine kinase) protein-coding - cfa-let-7e predicted by let-7 (Homo sapiens), and MTOR predicted by MTOR (Homo sapiens) according to Pubmed ID (25295787) 3887 cfa-miR-30c miR-30abcdef/30abe-5p/384-5p MIMAT0006605 miRNA BNIP3L autophagy down Canis lupus familiaris prediction 9615 608552 - - 25 - BCL2/adenovirus E1B 19kDa interacting protein 3-like protein-coding - cfa-miR-30c predicted by miR-30d (Homo sapiens), and BNIP3L predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 3888 cfa-miR-130a miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0006631 miRNA ATG2B autophagy down Canis lupus familiaris prediction 9615 480428 - Ensembl:ENSCAFG00000017729 8 - autophagy related 2B protein-coding - cfa-miR-130a predicted by miR-130a (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (22902544) 3889 cfa-miR-497 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0006691 miRNA ATG5 autophagy down Canis lupus familiaris prediction 9615 610868 - Ensembl:ENSCAFG00000003701 12 - autophagy related 5 protein-coding - cfa-miR-497 predicted by miR-16 (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (23143396) 3890 cfa-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0009830 miRNA ATG7 autophagy down Canis lupus familiaris prediction 9615 476533 - - 20 - autophagy related 7 protein-coding - cfa-miR-20b predicted by miR-17 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 3891 cfa-let-7g let-7/98/4458/4500 MIMAT0006637 miRNA MTOR autophagy down Canis lupus familiaris prediction 9615 478232 FRAP1 Ensembl:ENSCAFG00000016648 2 - mechanistic target of rapamycin (serine/threonine kinase) protein-coding - cfa-let-7g predicted by let-7 (Homo sapiens), and MTOR predicted by MTOR (Homo sapiens) according to Pubmed ID (25295787) 3892 cfa-miR-429 miR-200bc/429/548a MIMAT0001539 miRNA UBQLN1 autophagy down Canis lupus familiaris prediction 9615 476312 - - 1 - ubiquilin 1 protein-coding - cfa-miR-429 predicted by miR-200c (Homo sapiens), and UBQLN1 predicted by UBQLN1 (Homo sapiens) according to Pubmed ID (25044403) 3893 cfa-miR-449 miR-34ac/34bc-5p/449abc/449c-5p MIMAT0001544 miRNA ATG9A autophagy down Canis lupus familiaris prediction 9615 102154798 - Ensembl:ENSCAFG00000015071 37 - autophagy related 9A protein-coding - cfa-miR-449 predicted by miR-34a (Homo sapiens),miR-34a (Rattus norvegicus), and ATG9A predicted by Atg9a (Rattus norvegicus),ATG9A (Homo sapiens) according to Pubmed ID (22902544),(24728149),(24973144) 3894 cfa-let-7f let-7/98/4458/4500 MIMAT0006610 miRNA ATG7 autophagy down Canis lupus familiaris prediction 9615 476533 - - 20 - autophagy related 7 protein-coding - cfa-let-7f predicted by let-7a (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23143396) 3895 cfa-miR-93 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006696 miRNA FYCO1 autophagy down Canis lupus familiaris prediction 9615 476649 - Ensembl:ENSCAFG00000013851 20 - FYVE and coiled-coil domain containing 1 protein-coding - cfa-miR-93 predicted by miR-93 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3896 cfa-miR-181b miR-181abcd/4262 MIMAT0006708 miRNA TP63 autophagy down Canis lupus familiaris prediction 9615 488125 TP73L Ensembl:ENSCAFG00000013961 34 - tumor protein p63 protein-coding - cfa-miR-181b predicted by miR-181a (Homo sapiens), and TP63 predicted by TP63 (Homo sapiens) according to Pubmed ID (22356768) 3897 cfa-miR-15a miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0006647 miRNA ATG5 autophagy down Canis lupus familiaris prediction 9615 610868 - Ensembl:ENSCAFG00000003701 12 - autophagy related 5 protein-coding - cfa-miR-15a predicted by miR-16 (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (23143396) 3898 cfa-let-7e let-7/98/4458/4500 MIMAT0006608 miRNA IGF1R autophagy down Canis lupus familiaris prediction 9615 442951 - - 3 - insulin-like growth factor 1 receptor protein-coding - cfa-let-7e predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 3899 cfa-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006651 miRNA HIF1A autophagy down Canis lupus familiaris prediction 9615 480348 - Ensembl:ENSCAFG00000015718 8 - hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding - cfa-miR-20a predicted by miR-20a (Homo sapiens), and HIF1A predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 3900 cfa-miR-148a miR-148ab-3p/152 MIMAT0006622 miRNA ATG14 autophagy down Canis lupus familiaris prediction 9615 490704 - Ensembl:ENSCAFG00000015046 8 - autophagy related 14 protein-coding - cfa-miR-148a predicted by miR-152 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (25650716) 3901 cfa-miR-211 miR-204/204b/211 MIMAT0009867 miRNA TRPM3 autophagy down Canis lupus familiaris prediction 9615 476326 - Ensembl:ENSCAFG00000001849 1 - transient receptor potential cation channel, subfamily M, member 3 protein-coding - cfa-miR-211 predicted by miR-204 (Homo sapiens), and TRPM3 predicted by TRPM3 (Homo sapiens) according to Pubmed ID (25517751) 3902 cfa-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0009830 miRNA BECN1 autophagy down Canis lupus familiaris prediction 9615 480513 - - 9 - beclin 1, autophagy related protein-coding - cfa-miR-20b predicted by miR-17-5p (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (24755562),(25435430),(25485521) 3903 cfa-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006651 miRNA ATG7 autophagy down Canis lupus familiaris prediction 9615 476533 - - 20 - autophagy related 7 protein-coding - cfa-miR-20a predicted by miR-17 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 3904 cfa-let-7g let-7/98/4458/4500 MIMAT0006637 miRNA ATG7 autophagy down Canis lupus familiaris prediction 9615 476533 - - 20 - autophagy related 7 protein-coding - cfa-let-7g predicted by let-7a (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23143396) 3905 cfa-miR-144 miR-144 MIMAT0006734 miRNA MAPK1 autophagy down Canis lupus familiaris prediction 9615 477575 ERK2 Ensembl:ENSCAFG00000015421 26 - mitogen-activated protein kinase 1 protein-coding - cfa-miR-144 predicted by miR-144 (Homo sapiens), and MAPK1 predicted by MAPK1 (Homo sapiens) according to Pubmed ID (25060662) 3906 cfa-let-7a let-7/98/4458/4500 MIMAT0006594 miRNA MTOR autophagy down Canis lupus familiaris prediction 9615 478232 FRAP1 Ensembl:ENSCAFG00000016648 2 - mechanistic target of rapamycin (serine/threonine kinase) protein-coding - cfa-let-7a predicted by let-7 (Homo sapiens), and MTOR predicted by MTOR (Homo sapiens) according to Pubmed ID (25295787) 3907 cfa-miR-335 miR-335/335-5p MIMAT0006624 miRNA ULK2 autophagy down Canis lupus familiaris prediction 9615 489525 - Ensembl:ENSCAFG00000018126 5 - unc-51 like autophagy activating kinase 2 protein-coding - cfa-miR-335 predicted by miR-335 (Homo sapiens), and ULK2 predicted by ULK2 (Homo sapiens) according to Pubmed ID (18185580) 3908 cfa-miR-204 miR-204/204b/211 MIMAT0006598 miRNA MAP1LC3B autophagy down Canis lupus familiaris prediction 9615 479619 - - 5 - microtubule-associated protein 1 light chain 3 beta protein-coding - cfa-miR-204 predicted by miR-204 (Homo sapiens),miR-204 (Rattus norvegicus), and MAP1LC3B predicted by Map1lc3b (Rattus norvegicus),MAP1LC3B (Homo sapiens) according to Pubmed ID (21316776),(21631941),(22516261),(25209181),(25517751) 3909 cfa-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0009830 miRNA ATG5 autophagy down Canis lupus familiaris prediction 9615 610868 - Ensembl:ENSCAFG00000003701 12 - autophagy related 5 protein-coding - cfa-miR-20b predicted by miR-20a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (25485521) 3910 cfa-miR-124 miR-124/124ab/506 MIMAT0006657 miRNA ANTXR2 autophagy down Canis lupus familiaris prediction 9615 487821 - - 32 - anthrax toxin receptor 2 protein-coding - cfa-miR-124 predicted by miR-124 (Homo sapiens), and ANTXR2 predicted by ANTXR2 (Homo sapiens) according to Pubmed ID (25736362) 3911 cfa-miR-15a miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0006647 miRNA BCL2L2 autophagy down Canis lupus familiaris prediction 9615 490611 BCL-W Ensembl:ENSCAFG00000031094 8 - BCL2-like 2 protein-coding - cfa-miR-15a predicted by miR-15b (Mus musculus), and BCL2L2 predicted by Bcl2l2 (Mus musculus) according to Pubmed ID (21770019) 3912 cfa-miR-497 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0006691 miRNA ATG7 autophagy down Canis lupus familiaris prediction 9615 476533 - - 20 - autophagy related 7 protein-coding - cfa-miR-497 predicted by miR-16 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23143396) 3913 cfa-miR-132 miR-132/212/212-3p MIMAT0006732 miRNA FOXO3 autophagy down Canis lupus familiaris prediction 9615 481954 FKHRL1|FOXO3A - 12 - forkhead box O3 protein-coding - cfa-miR-132 predicted by miR-132 (Mus musculus), and FOXO3 predicted by Foxo3 (Mus musculus) according to Pubmed ID (23011132) 3914 cfa-miR-16 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0006648 miRNA ATG14 autophagy down Canis lupus familiaris prediction 9615 490704 - Ensembl:ENSCAFG00000015046 8 - autophagy related 14 protein-coding - cfa-miR-16 predicted by miR-195 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 3915 cfa-miR-98 let-7/98/4458/4500 MIMAT0006756 miRNA ATG7 autophagy down Canis lupus familiaris prediction 9615 476533 - - 20 - autophagy related 7 protein-coding - cfa-miR-98 predicted by let-7a (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23143396) 3916 cfa-let-7a let-7/98/4458/4500 MIMAT0006594 miRNA OLR1 autophagy down Canis lupus familiaris prediction 9615 486694 - Ensembl:ENSCAFG00000013495 27 - oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding - cfa-let-7a predicted by let-7g (Mus musculus), and OLR1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 3917 cfa-miR-15a miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0006647 miRNA BAG5 autophagy down Canis lupus familiaris prediction 9615 480444 - - 8 - BCL2-associated athanogene 5 protein-coding - cfa-miR-15a predicted by miR-16 (Mus musculus), and BAG5 predicted by Bag5 (Mus musculus) according to Pubmed ID (21770019) 3918 cfa-miR-99a miR-99ab/100 MIMAT0006668 miRNA MTOR autophagy down Canis lupus familiaris prediction 9615 478232 FRAP1 Ensembl:ENSCAFG00000016648 2 - mechanistic target of rapamycin (serine/threonine kinase) protein-coding - cfa-miR-99a predicted by miR-100 (Homo sapiens), and MTOR predicted by MTOR (Homo sapiens) according to Pubmed ID (25026290) 3919 cfa-miR-21 miR-21/590-5p MIMAT0006741 miRNA BECN1 autophagy down Canis lupus familiaris prediction 9615 480513 - - 9 - beclin 1, autophagy related protein-coding - cfa-miR-21 predicted by miR-21 (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (23834154) 3920 cfa-miR-93 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006696 miRNA BECN1 autophagy down Canis lupus familiaris prediction 9615 480513 - - 9 - beclin 1, autophagy related protein-coding - cfa-miR-93 predicted by miR-17-5p (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (24755562),(25435430),(25485521) 3921 cfa-miR-155 miR-155 MIMAT0006671 miRNA RHEB autophagy down Canis lupus familiaris prediction 9615 475545 - Ensembl:ENSCAFG00000004894 16 - Ras homolog enriched in brain protein-coding - cfa-miR-155 predicted by miR-155 (Homo sapiens), and RHEB predicted by RHEB (Homo sapiens) according to Pubmed ID (24130493),(24262949) 3922 cfa-miR-155 miR-155 MIMAT0006671 miRNA RICTOR autophagy down Canis lupus familiaris prediction 9615 479356 - Ensembl:ENSCAFG00000018637 4 - RPTOR independent companion of MTOR, complex 2 protein-coding - cfa-miR-155 predicted by miR-155 (Homo sapiens), and RICTOR predicted by RICTOR (Homo sapiens) according to Pubmed ID (24262949) 3923 cfa-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006695 miRNA ATG5 autophagy down Canis lupus familiaris prediction 9615 610868 - Ensembl:ENSCAFG00000003701 12 - autophagy related 5 protein-coding - cfa-miR-106b predicted by miR-20a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (25485521) 3924 cfa-miR-375 miR-375 MIMAT0009871 miRNA SP1 autophagy down Canis lupus familiaris prediction 9615 486507 - - 27 - Sp1 transcription factor protein-coding - cfa-miR-375 predicted by miR-375 (Homo sapiens), and SP1 predicted by SP1 (Homo sapiens) according to Pubmed ID (22606351) 3925 cfa-let-7e let-7/98/4458/4500 MIMAT0006608 miRNA OLR1 autophagy down Canis lupus familiaris prediction 9615 486694 - Ensembl:ENSCAFG00000013495 27 - oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding - cfa-let-7e predicted by let-7g (Mus musculus), and OLR1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 3926 cfa-miR-34c miR-34ac/34bc-5p/449abc/449c-5p MIMAT0006693 miRNA ATG9A autophagy down Canis lupus familiaris prediction 9615 102154798 - Ensembl:ENSCAFG00000015071 37 - autophagy related 9A protein-coding - cfa-miR-34c predicted by miR-34a (Homo sapiens),miR-34a (Rattus norvegicus), and ATG9A predicted by Atg9a (Rattus norvegicus),ATG9A (Homo sapiens) according to Pubmed ID (22902544),(24728149),(24973144) 3927 cfa-miR-30c miR-30abcdef/30abe-5p/384-5p MIMAT0006605 miRNA BECN1 autophagy down Canis lupus familiaris prediction 9615 480513 - - 9 - beclin 1, autophagy related protein-coding - cfa-miR-30c predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and BECN1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 3928 cfa-miR-15b miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0006676 miRNA BCL2L2 autophagy down Canis lupus familiaris prediction 9615 490611 BCL-W Ensembl:ENSCAFG00000031094 8 - BCL2-like 2 protein-coding - cfa-miR-15b predicted by miR-15b (Mus musculus), and BCL2L2 predicted by Bcl2l2 (Mus musculus) according to Pubmed ID (21770019) 3929 cfa-miR-23a miR-23abc/23b-3p MIMAT0006640 miRNA ATG12 autophagy down Canis lupus familiaris prediction 9615 474636 - - 11 - autophagy related 12 protein-coding - cfa-miR-23a predicted by miR-23b (Homo sapiens), and ATG12 predicted by ATG12 (Homo sapiens) according to Pubmed ID (23916944),(24145177) 3930 cfa-miR-21 miR-21/590-5p MIMAT0006741 miRNA BCL2 autophagy down Canis lupus familiaris prediction 9615 403416 BCL-2 - 1 - B-cell CLL/lymphoma 2 protein-coding - cfa-miR-21 predicted by miR-21 (Homo sapiens), and BCL2 predicted by BCL2 (Homo sapiens) according to Pubmed ID (23834154) 3931 cfa-miR-32 miR-25/32/92abc/363/363-3p/367 MIMAT0006597 miRNA ULK1 autophagy down Canis lupus familiaris prediction 9615 477437 - Ensembl:ENSCAFG00000006446 26 - unc-51 like autophagy activating kinase 1 protein-coding - cfa-miR-32 predicted by miR-25 (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (25026296) 3932 cfa-miR-192 miR-192/215 MIMAT0006632 miRNA MAP1LC3B autophagy down Canis lupus familiaris prediction 9615 479619 - - 5 - microtubule-associated protein 1 light chain 3 beta protein-coding - cfa-miR-192 predicted by miR-192 (Homo sapiens), and MAP1LC3B predicted by MAP1LC3B (Homo sapiens) according to Pubmed ID (22135297) 3933 cfa-let-7c let-7/98/4458/4500 MIMAT0006669 miRNA MTOR autophagy down Canis lupus familiaris prediction 9615 478232 FRAP1 Ensembl:ENSCAFG00000016648 2 - mechanistic target of rapamycin (serine/threonine kinase) protein-coding - cfa-let-7c predicted by let-7 (Homo sapiens), and MTOR predicted by MTOR (Homo sapiens) according to Pubmed ID (25295787) 3934 cfa-miR-195 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0006692 miRNA BCL2L2 autophagy down Canis lupus familiaris prediction 9615 490611 BCL-W Ensembl:ENSCAFG00000031094 8 - BCL2-like 2 protein-coding - cfa-miR-195 predicted by miR-15b (Mus musculus), and BCL2L2 predicted by Bcl2l2 (Mus musculus) according to Pubmed ID (21770019) 3935 cfa-miR-30d miR-30abcdef/30abe-5p/384-5p MIMAT0006616 miRNA ATG5 autophagy down Canis lupus familiaris prediction 9615 610868 - Ensembl:ENSCAFG00000003701 12 - autophagy related 5 protein-coding - cfa-miR-30d predicted by miR-30a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22395361),(22617440),(22902544),(23274497),(24148619) 3936 cfa-miR-29a miR-29abcd MIMAT0006626 miRNA ATG14 autophagy down Canis lupus familiaris prediction 9615 490704 - Ensembl:ENSCAFG00000015046 8 - autophagy related 14 protein-coding - cfa-miR-29a predicted by miR-29b (Bos taurus), and ATG14 predicted by ATG14 (Bos taurus) according to Pubmed ID (25234643) 3937 cfa-miR-30a miR-30abcdef/30abe-5p/384-5p MIMAT0006604 miRNA ATG12 autophagy down Canis lupus familiaris prediction 9615 474636 - - 11 - autophagy related 12 protein-coding - cfa-miR-30a predicted by miR-30b (Homo sapiens), and ATG12 predicted by ATG12 (Homo sapiens) according to Pubmed ID (22647547),(23274497) 3938 cfa-let-7c let-7/98/4458/4500 MIMAT0006669 miRNA OLR1 autophagy down Canis lupus familiaris prediction 9615 486694 - Ensembl:ENSCAFG00000013495 27 - oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding - cfa-let-7c predicted by let-7g (Mus musculus), and OLR1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 3939 cfa-miR-93 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0006696 miRNA HIF1A autophagy down Canis lupus familiaris prediction 9615 480348 - Ensembl:ENSCAFG00000015718 8 - hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding - cfa-miR-93 predicted by miR-20a (Homo sapiens), and HIF1A predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 3940 cfa-miR-34a miR-34ac/34bc-5p/449abc/449c-5p MIMAT0006690 miRNA ATG4B autophagy down Canis lupus familiaris prediction 9615 609599 - - 25 - autophagy related 4B, cysteine peptidase protein-coding - cfa-miR-34a predicted by miR-34a (Homo sapiens), and ATG4B predicted by ATG4B (Homo sapiens) according to Pubmed ID (24755409) 3941 bta-miR-23a miR-23abc/23b-3p MIMAT0003827 miRNA ATG12 autophagy down Bos taurus prediction 9913 767903 - BGD:BT29631|Ensembl:ENSBTAG00000017525 10 - ATG12 autophagy related 12 homolog (S. cerevisiae) protein-coding - bta-miR-23a predicted by miR-23b (Homo sapiens), and ATG12 predicted by ATG12 (Homo sapiens) according to Pubmed ID (23916944),(24145177) 3942 bta-miR-302c miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0009281 miRNA SQSTM1 autophagy down Bos taurus prediction 9913 338045 - BGD:BT16900|Ensembl:ENSBTAG00000015591 7 - sequestosome 1 protein-coding - bta-miR-302c predicted by miR-372 (Homo sapiens), and SQSTM1 predicted by SQSTM1 (Homo sapiens) according to Pubmed ID (24991827) 3943 bta-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0009218 miRNA BECN1 autophagy down Bos taurus prediction 9913 527278 ATG6 BGD:BT26123|Ensembl:ENSBTAG00000019914 19 - beclin 1, autophagy related protein-coding - bta-miR-106b predicted by miR-17-5p (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (24755562),(25435430),(25485521) 3944 bta-let-7f let-7/98/4458/4500 MIMAT0003519 miRNA IGF1R autophagy down Bos taurus prediction 9913 281848 IGFR1 BGD:BT29334|Ensembl:ENSBTAG00000021527 21 - insulin-like growth factor 1 receptor protein-coding - bta-let-7f predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 3945 bta-miR-378 miR-378/422a/378bcdefhi MIMAT0009305 miRNA FYCO1 autophagy down Bos taurus prediction 9913 100139246 - BGD:BT30103|Ensembl:ENSBTAG00000015698 22 - FYVE and coiled-coil domain containing 1 protein-coding - bta-miR-378 predicted by miR-378a (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (23622248) 3946 bta-miR-144 miR-144 MIMAT0009234 miRNA GSK3B autophagy down Bos taurus prediction 9913 790875 GSK3beta - 1 - glycogen synthase kinase 3 beta protein-coding - bta-miR-144 predicted by miR-144 (Homo sapiens), and GSK3B predicted by GSK3B (Homo sapiens) according to Pubmed ID (25060662) 3947 bta-miR-15a miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0004334 miRNA BCL2L2 autophagy down Bos taurus prediction 9913 767601 - BGD:BT13347|Ensembl:ENSBTAG00000019692 10 - BCL2-like 2 protein-coding - bta-miR-15a predicted by miR-15b (Mus musculus), and BCL2L2 predicted by Bcl2l2 (Mus musculus) according to Pubmed ID (21770019) 3948 bta-miR-195 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0004335 miRNA BCL2L2 autophagy down Bos taurus prediction 9913 767601 - BGD:BT13347|Ensembl:ENSBTAG00000019692 10 - BCL2-like 2 protein-coding - bta-miR-195 predicted by miR-15b (Mus musculus), and BCL2L2 predicted by Bcl2l2 (Mus musculus) according to Pubmed ID (21770019) 3949 bta-miR-302d miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0009279 miRNA ATG7 autophagy down Bos taurus prediction 9913 787967 - Ensembl:ENSBTAG00000035827 22 - autophagy related 7 protein-coding - bta-miR-302d predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 3950 bta-miR-429 miR-200bc/429/548a MIMAT0009315 miRNA UBQLN1 autophagy down Bos taurus prediction 9913 282392 - Ensembl:ENSBTAG00000014827 8 - ubiquilin 1 protein-coding - bta-miR-429 predicted by miR-200c (Homo sapiens), and UBQLN1 predicted by UBQLN1 (Homo sapiens) according to Pubmed ID (25044403) 3951 bta-miR-32 miR-25/32/92abc/363/363-3p/367 MIMAT0009283 miRNA UVRAG autophagy down Bos taurus prediction 9913 614285 - BGD:BT19521|Ensembl:ENSBTAG00000016355 15 - UV radiation resistance associated gene protein-coding - bta-miR-32 predicted by miR-32 (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22135297) 3952 bta-miR-93 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003837 miRNA FYCO1 autophagy down Bos taurus prediction 9913 100139246 - BGD:BT30103|Ensembl:ENSBTAG00000015698 22 - FYVE and coiled-coil domain containing 1 protein-coding - bta-miR-93 predicted by miR-93 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3953 bta-miR-17-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003815 miRNA ULK1 autophagy down Bos taurus prediction 9913 526310 - BGD:BT26556|Ensembl:ENSBTAG00000012987 17 - unc-51-like kinase 1 (C. elegans) protein-coding - bta-miR-17-5p predicted by miR-106b (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 3954 bta-miR-301b miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0009277 miRNA ATG2B autophagy down Bos taurus prediction 9913 519961 - Ensembl:ENSBTAG00000012833 21 - autophagy related 2B protein-coding - bta-miR-301b predicted by miR-130a (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (22902544) 3955 bta-miR-155 miR-155 MIMAT0009241 miRNA RICTOR autophagy down Bos taurus prediction 9913 527459 - BGD:BT26810|Ensembl:ENSBTAG00000006697 20 - RPTOR independent companion of MTOR, complex 2 protein-coding - bta-miR-155 predicted by miR-155 (Homo sapiens), and RICTOR predicted by RICTOR (Homo sapiens) according to Pubmed ID (24262949) 3956 bta-miR-15b miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0003792 miRNA BCL2L2 autophagy down Bos taurus prediction 9913 767601 - BGD:BT13347|Ensembl:ENSBTAG00000019692 10 - BCL2-like 2 protein-coding - bta-miR-15b predicted by miR-15b (Mus musculus), and BCL2L2 predicted by Bcl2l2 (Mus musculus) according to Pubmed ID (21770019) 3957 bta-let-7c let-7/98/4458/4500 MIMAT0004332 miRNA MTOR autophagy down Bos taurus prediction 9913 100139219 - BGD:BT29876|Ensembl:ENSBTAG00000015325 16 - mechanistic target of rapamycin (serine/threonine kinase) protein-coding - bta-let-7c predicted by let-7 (Homo sapiens), and MTOR predicted by MTOR (Homo sapiens) according to Pubmed ID (25295787) 3958 bta-let-7b let-7/98/4458/4500 MIMAT0004331 miRNA MTOR autophagy down Bos taurus prediction 9913 100139219 - BGD:BT29876|Ensembl:ENSBTAG00000015325 16 - mechanistic target of rapamycin (serine/threonine kinase) protein-coding - bta-let-7b predicted by let-7 (Homo sapiens), and MTOR predicted by MTOR (Homo sapiens) according to Pubmed ID (25295787) 3959 bta-miR-195 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0004335 miRNA ATG5 autophagy down Bos taurus prediction 9913 532686 - BGD:BT28451|Ensembl:ENSBTAG00000005400 9 - ATG5 autophagy related 5 homolog (S. cerevisiae) protein-coding - bta-miR-195 predicted by miR-16 (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (23143396) 3960 bta-miR-195 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0004335 miRNA ATG14 autophagy down Bos taurus prediction 9913 538831 - BGD:BT20206|Ensembl:ENSBTAG00000010795 10 - ATG14 autophagy related 14 homolog (S. cerevisiae) protein-coding - bta-miR-195 predicted by miR-195 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 3961 bta-miR-101 miR-101/101ab MIMAT0003520 miRNA ATG4D autophagy down Bos taurus prediction 9913 615657 - BGD:BT22830|Ensembl:ENSBTAG00000010727 7 - ATG4 autophagy related 4 homolog D (S. cerevisiae) protein-coding - bta-miR-101 predicted by miR-101 (Homo sapiens), and ATG4D predicted by (Homo sapiens),ATG4D (Homo sapiens) according to Pubmed ID (21915098),(22085996),(22902544),(23483142) 3962 bta-miR-93 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003837 miRNA HIF1A autophagy down Bos taurus prediction 9913 281814 - BGD:BT12172|Ensembl:ENSBTAG00000020935 10 - hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding - bta-miR-93 predicted by miR-20a (Homo sapiens), and HIF1A predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 3963 bta-miR-301b miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0009277 miRNA FYCO1 autophagy down Bos taurus prediction 9913 100139246 - BGD:BT30103|Ensembl:ENSBTAG00000015698 22 - FYVE and coiled-coil domain containing 1 protein-coding - bta-miR-301b predicted by miR-130b (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 3964 bta-miR-454 miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0009326 miRNA RB1CC1 autophagy down Bos taurus prediction 9913 539858 - BGD:BT19837|Ensembl:ENSBTAG00000000878 14 - RB1-inducible coiled-coil 1 protein-coding - bta-miR-454 predicted by miR-133b (Homo sapiens), and RB1CC1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 3965 bta-miR-29d miR-29abcd MIMAT0009275 miRNA PSME4 autophagy down Bos taurus prediction 9913 528142 - BGD:BT15703|Ensembl:ENSBTAG00000020262 11 - proteasome (prosome, macropain) activator subunit 4 protein-coding - bta-miR-29d predicted by miR-29b (Homo sapiens), and PSME4 predicted by PSME4 (Homo sapiens) according to Pubmed ID (25234165) 3966 bta-let-7a let-7/98/4458/4500 MIMAT0003844 miRNA MTOR autophagy down Bos taurus prediction 9913 100139219 - BGD:BT29876|Ensembl:ENSBTAG00000015325 16 - mechanistic target of rapamycin (serine/threonine kinase) protein-coding - bta-let-7a predicted by let-7 (Homo sapiens), and MTOR predicted by MTOR (Homo sapiens) according to Pubmed ID (25295787) 3967 bta-miR-216b miR-216b/216b-5p MIMAT0009266 miRNA BECN1 autophagy down Bos taurus prediction 9913 527278 ATG6 BGD:BT26123|Ensembl:ENSBTAG00000019914 19 - beclin 1, autophagy related protein-coding - bta-miR-216b predicted by miR-216b (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (24681041) 3968 bta-miR-30a-5p miR-30abcdef/30abe-5p/384-5p MIMAT0003841 miRNA ATG5 autophagy down Bos taurus prediction 9913 532686 - BGD:BT28451|Ensembl:ENSBTAG00000005400 9 - ATG5 autophagy related 5 homolog (S. cerevisiae) protein-coding - bta-miR-30a-5p predicted by miR-30a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22395361),(22617440),(22902544),(23274497),(24148619) 3969 bta-miR-181d miR-181abcd/4262 MIMAT0009243 miRNA ATG5 autophagy down Bos taurus prediction 9913 532686 - BGD:BT28451|Ensembl:ENSBTAG00000005400 9 - ATG5 autophagy related 5 homolog (S. cerevisiae) protein-coding - bta-miR-181d predicted by miR-181a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22356768),(22902544),(23322078) 3970 bta-miR-98 let-7/98/4458/4500 MIMAT0003809 miRNA MTOR autophagy down Bos taurus prediction 9913 100139219 - BGD:BT29876|Ensembl:ENSBTAG00000015325 16 - mechanistic target of rapamycin (serine/threonine kinase) protein-coding - bta-miR-98 predicted by let-7 (Homo sapiens), and MTOR predicted by MTOR (Homo sapiens) according to Pubmed ID (25295787) 3971 bta-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0009218 miRNA HIF1A autophagy down Bos taurus prediction 9913 281814 - BGD:BT12172|Ensembl:ENSBTAG00000020935 10 - hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding - bta-miR-106b predicted by miR-20a (Homo sapiens), and HIF1A predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 3972 bta-miR-374b miR-374ab MIMAT0009302 miRNA ATG12 autophagy down Bos taurus prediction 9913 767903 - BGD:BT29631|Ensembl:ENSBTAG00000017525 10 - ATG12 autophagy related 12 homolog (S. cerevisiae) protein-coding - bta-miR-374b predicted by miR-374a (Homo sapiens), and ATG12 predicted by ATG12 (Homo sapiens) according to Pubmed ID (22356768) 3973 bta-miR-302b miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0009280 miRNA ULK1 autophagy down Bos taurus prediction 9913 526310 - BGD:BT26556|Ensembl:ENSBTAG00000012987 17 - unc-51-like kinase 1 (C. elegans) protein-coding - bta-miR-302b predicted by miR-291 (Mus musculus), and ULK1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 3974 bta-miR-302d miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0009279 miRNA ULK1 autophagy down Bos taurus prediction 9913 526310 - BGD:BT26556|Ensembl:ENSBTAG00000012987 17 - unc-51-like kinase 1 (C. elegans) protein-coding - bta-miR-302d predicted by miR-291 (Mus musculus), and ULK1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 3975 bta-miR-15b miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0003792 miRNA BAG5 autophagy down Bos taurus prediction 9913 522854 - BGD:BT25018|Ensembl:ENSBTAG00000017361 21 - BCL2-associated athanogene 5 protein-coding - bta-miR-15b predicted by miR-16 (Mus musculus), and BAG5 predicted by Bag5 (Mus musculus) according to Pubmed ID (21770019) 3976 bta-miR-15a miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0004334 miRNA ATG14 autophagy down Bos taurus prediction 9913 538831 - BGD:BT20206|Ensembl:ENSBTAG00000010795 10 - ATG14 autophagy related 14 homolog (S. cerevisiae) protein-coding - bta-miR-15a predicted by miR-195 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 3977 bta-miR-148b miR-148ab-3p/152 MIMAT0003814 miRNA ATG14 autophagy down Bos taurus prediction 9913 538831 - BGD:BT20206|Ensembl:ENSBTAG00000010795 10 - ATG14 autophagy related 14 homolog (S. cerevisiae) protein-coding - bta-miR-148b predicted by miR-152 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (25650716) 3978 bta-miR-1271 miR-96/507/1271 MIMAT0009975 miRNA ATG7 autophagy down Bos taurus prediction 9913 787967 - Ensembl:ENSBTAG00000035827 22 - autophagy related 7 protein-coding - bta-miR-1271 predicted by miR-96 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (25333253) 3979 bta-miR-137 miR-137/137ab MIMAT0009231 miRNA BNIP3L autophagy down Bos taurus prediction 9913 534615 - BGD:BT17341|Ensembl:ENSBTAG00000021307 8 - BCL2/adenovirus E1B 19kDa interacting protein 3-like protein-coding - bta-miR-137 predicted by miR-137 (Homo sapiens), and BNIP3L predicted by BNIP3L (Homo sapiens) according to Pubmed ID (24573672) 3980 bta-miR-106 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003784 miRNA ATG16L1 autophagy down Bos taurus prediction 9913 509587 - BGD:BT16113|Ensembl:ENSBTAG00000003928 3 - ATG16 autophagy related 16-like 1 (S. cerevisiae) protein-coding - bta-miR-106 predicted by miR-106b (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 3981 bta-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003527 miRNA ATG7 autophagy down Bos taurus prediction 9913 787967 - Ensembl:ENSBTAG00000035827 22 - autophagy related 7 protein-coding - bta-miR-20a predicted by miR-17 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 3982 bta-miR-30c miR-30abcdef/30abe-5p/384-5p MIMAT0003850 miRNA BECN1 autophagy down Bos taurus prediction 9913 527278 ATG6 BGD:BT26123|Ensembl:ENSBTAG00000019914 19 - beclin 1, autophagy related protein-coding - bta-miR-30c predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and BECN1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 3983 bta-miR-302b miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0009280 miRNA SQSTM1 autophagy down Bos taurus prediction 9913 338045 - BGD:BT16900|Ensembl:ENSBTAG00000015591 7 - sequestosome 1 protein-coding - bta-miR-302b predicted by miR-372 (Homo sapiens), and SQSTM1 predicted by SQSTM1 (Homo sapiens) according to Pubmed ID (24991827) 3984 bta-miR-301b miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0009277 miRNA RB1CC1 autophagy down Bos taurus prediction 9913 539858 - BGD:BT19837|Ensembl:ENSBTAG00000000878 14 - RB1-inducible coiled-coil 1 protein-coding - bta-miR-301b predicted by miR-133b (Homo sapiens), and RB1CC1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 3985 bta-miR-16b miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0003525 miRNA BAG5 autophagy down Bos taurus prediction 9913 522854 - BGD:BT25018|Ensembl:ENSBTAG00000017361 21 - BCL2-associated athanogene 5 protein-coding - bta-miR-16b predicted by miR-16 (Mus musculus), and BAG5 predicted by Bag5 (Mus musculus) according to Pubmed ID (21770019) 3986 bta-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003796 miRNA ATG16L1 autophagy down Bos taurus prediction 9913 509587 - BGD:BT16113|Ensembl:ENSBTAG00000003928 3 - ATG16 autophagy related 16-like 1 (S. cerevisiae) protein-coding - bta-miR-20b predicted by miR-106b (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 3987 bta-miR-30f miR-30abcdef/30abe-5p/384-5p MIMAT0009282 miRNA BECN1 autophagy down Bos taurus prediction 9913 527278 ATG6 BGD:BT26123|Ensembl:ENSBTAG00000019914 19 - beclin 1, autophagy related protein-coding - bta-miR-30f predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and BECN1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 3988 bta-miR-98 let-7/98/4458/4500 MIMAT0003809 miRNA IGF1R autophagy down Bos taurus prediction 9913 281848 IGFR1 BGD:BT29334|Ensembl:ENSBTAG00000021527 21 - insulin-like growth factor 1 receptor protein-coding - bta-miR-98 predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 3989 bta-miR-374a miR-374ab MIMAT0004342 miRNA UVRAG autophagy down Bos taurus prediction 9913 614285 - BGD:BT19521|Ensembl:ENSBTAG00000016355 15 - UV radiation resistance associated gene protein-coding - bta-miR-374a predicted by miR-374a (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22356768) 3990 bta-miR-17-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003815 miRNA ATG16L1 autophagy down Bos taurus prediction 9913 509587 - BGD:BT16113|Ensembl:ENSBTAG00000003928 3 - ATG16 autophagy related 16-like 1 (S. cerevisiae) protein-coding - bta-miR-17-5p predicted by miR-106b (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 3991 bta-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0009218 miRNA ATG16L1 autophagy down Bos taurus prediction 9913 509587 - BGD:BT16113|Ensembl:ENSBTAG00000003928 3 - ATG16 autophagy related 16-like 1 (S. cerevisiae) protein-coding - bta-miR-106b predicted by miR-106b (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 3992 bta-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003796 miRNA HIF1A autophagy down Bos taurus prediction 9913 281814 - BGD:BT12172|Ensembl:ENSBTAG00000020935 10 - hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding - bta-miR-20b predicted by miR-20a (Homo sapiens), and HIF1A predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 3993 bta-miR-301a miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0009276 miRNA RB1CC1 autophagy down Bos taurus prediction 9913 539858 - BGD:BT19837|Ensembl:ENSBTAG00000000878 14 - RB1-inducible coiled-coil 1 protein-coding - bta-miR-301a predicted by miR-133b (Homo sapiens), and RB1CC1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 3994 bta-let-7e let-7/98/4458/4500 MIMAT0004333 miRNA IGF1R autophagy down Bos taurus prediction 9913 281848 IGFR1 BGD:BT29334|Ensembl:ENSBTAG00000021527 21 - insulin-like growth factor 1 receptor protein-coding - bta-let-7e predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 3995 bta-miR-30d miR-30abcdef/30abe-5p/384-5p MIMAT0003533 miRNA BECN1 autophagy down Bos taurus prediction 9913 527278 ATG6 BGD:BT26123|Ensembl:ENSBTAG00000019914 19 - beclin 1, autophagy related protein-coding - bta-miR-30d predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and BECN1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 3996 bta-miR-130b miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0009224 miRNA RB1CC1 autophagy down Bos taurus prediction 9913 539858 - BGD:BT19837|Ensembl:ENSBTAG00000000878 14 - RB1-inducible coiled-coil 1 protein-coding - bta-miR-130b predicted by miR-133b (Homo sapiens), and RB1CC1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 3997 bta-miR-106 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003784 miRNA ATG7 autophagy down Bos taurus prediction 9913 787967 - Ensembl:ENSBTAG00000035827 22 - autophagy related 7 protein-coding - bta-miR-106 predicted by miR-17 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 3998 bta-miR-16b miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0003525 miRNA BCL2L2 autophagy down Bos taurus prediction 9913 767601 - BGD:BT13347|Ensembl:ENSBTAG00000019692 10 - BCL2-like 2 protein-coding - bta-miR-16b predicted by miR-15b (Mus musculus), and BCL2L2 predicted by Bcl2l2 (Mus musculus) according to Pubmed ID (21770019) 3999 bta-miR-17-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003815 miRNA SQSTM1 autophagy down Bos taurus prediction 9913 338045 - BGD:BT16900|Ensembl:ENSBTAG00000015591 7 - sequestosome 1 protein-coding - bta-miR-17-5p predicted by miR-106b (Homo sapiens),miR-106 (Mus musculus), and SQSTM1 predicted by Sqstm1 (Mus musculus),SQSTM1 (Homo sapiens) according to Pubmed ID (21628417),(22441107),(25485521),(25617127) 4000 bta-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003796 miRNA ULK1 autophagy down Bos taurus prediction 9913 526310 - BGD:BT26556|Ensembl:ENSBTAG00000012987 17 - unc-51-like kinase 1 (C. elegans) protein-coding - bta-miR-20b predicted by miR-106b (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 4001 bta-miR-29c miR-29abcd MIMAT0003829 miRNA ATG9A autophagy down Bos taurus prediction 9913 540482 ATG9 BGD:BT13106|Ensembl:ENSBTAG00000020608 2 - ATG9 autophagy related 9 homolog A (S. cerevisiae) protein-coding - bta-miR-29c predicted by miR-29b (Bos taurus), and ATG9A predicted by ATG9A (Bos taurus) according to Pubmed ID (25234643) 4002 bta-miR-130a miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0009223 miRNA RB1CC1 autophagy down Bos taurus prediction 9913 539858 - BGD:BT19837|Ensembl:ENSBTAG00000000878 14 - RB1-inducible coiled-coil 1 protein-coding - bta-miR-130a predicted by miR-133b (Homo sapiens), and RB1CC1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 4003 bta-miR-451 miR-451 MIMAT0009323 miRNA TSC1 autophagy down Bos taurus prediction 9913 533440 - BGD:BT14906 11 - tuberous sclerosis 1 protein-coding - bta-miR-451 predicted by miR-451 (Homo sapiens), and TSC1 predicted by TSC1 (Homo sapiens) according to Pubmed ID (25209900) 4004 bta-miR-30e-5p miR-30abcdef/30abe-5p/384-5p MIMAT0003799 miRNA ATG12 autophagy down Bos taurus prediction 9913 767903 - BGD:BT29631|Ensembl:ENSBTAG00000017525 10 - ATG12 autophagy related 12 homolog (S. cerevisiae) protein-coding - bta-miR-30e-5p predicted by miR-30b (Homo sapiens), and ATG12 predicted by ATG12 (Homo sapiens) according to Pubmed ID (22647547),(23274497) 4005 bta-miR-301a miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0009276 miRNA FYCO1 autophagy down Bos taurus prediction 9913 100139246 - BGD:BT30103|Ensembl:ENSBTAG00000015698 22 - FYVE and coiled-coil domain containing 1 protein-coding - bta-miR-301a predicted by miR-130b (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 4006 bta-miR-30a-5p miR-30abcdef/30abe-5p/384-5p MIMAT0003841 miRNA BECN1 autophagy down Bos taurus prediction 9913 527278 ATG6 BGD:BT26123|Ensembl:ENSBTAG00000019914 19 - beclin 1, autophagy related protein-coding - bta-miR-30a-5p predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and BECN1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 4007 bta-miR-30e-5p miR-30abcdef/30abe-5p/384-5p MIMAT0003799 miRNA ATG5 autophagy down Bos taurus prediction 9913 532686 - BGD:BT28451|Ensembl:ENSBTAG00000005400 9 - ATG5 autophagy related 5 homolog (S. cerevisiae) protein-coding - bta-miR-30e-5p predicted by miR-30a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22395361),(22617440),(22902544),(23274497),(24148619) 4008 bta-miR-497 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0004343 miRNA ATG14 autophagy down Bos taurus prediction 9913 538831 - BGD:BT20206|Ensembl:ENSBTAG00000010795 10 - ATG14 autophagy related 14 homolog (S. cerevisiae) protein-coding - bta-miR-497 predicted by miR-195 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 4009 bta-miR-222 miR-221/222/222ab/1928 MIMAT0003530 miRNA CDKN1B autophagy down Bos taurus prediction 9913 512613 - BGD:BT28157|Ensembl:ENSBTAG00000018254 5 - cyclin-dependent kinase inhibitor 1B (p27, Kip1) protein-coding - bta-miR-222 predicted by miR-221 (Homo sapiens), and CDKN1B predicted by CDKN1B (Homo sapiens) according to Pubmed ID (25394488) 4010 bta-miR-101 miR-101/101ab MIMAT0003520 miRNA EZH2 autophagy down Bos taurus prediction 9913 509106 - BGD:BT10727|Ensembl:ENSBTAG00000009426 4 - enhancer of zeste homolog 2 (Drosophila) protein-coding - bta-miR-101 predicted by miR-101 (Homo sapiens), and EZH2 predicted by EZH2 (Homo sapiens) according to Pubmed ID (24211739) 4011 bta-miR-449b miR-34ac/34bc-5p/449abc/449c-5p MIMAT0009321 miRNA ATG9A autophagy down Bos taurus prediction 9913 540482 ATG9 BGD:BT13106|Ensembl:ENSBTAG00000020608 2 - ATG9 autophagy related 9 homolog A (S. cerevisiae) protein-coding - bta-miR-449b predicted by miR-34a (Homo sapiens),miR-34a (Rattus norvegicus), and ATG9A predicted by Atg9a (Rattus norvegicus),ATG9A (Homo sapiens) according to Pubmed ID (22902544),(24728149),(24973144) 4012 bta-miR-30e-5p miR-30abcdef/30abe-5p/384-5p MIMAT0003799 miRNA BECN1 autophagy down Bos taurus prediction 9913 527278 ATG6 BGD:BT26123|Ensembl:ENSBTAG00000019914 19 - beclin 1, autophagy related protein-coding - bta-miR-30e-5p predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and BECN1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 4013 bta-miR-211 miR-204/204b/211 MIMAT0009263 miRNA MAP1LC3B autophagy down Bos taurus prediction 9913 408001 - BGD:BT25974|Ensembl:ENSBTAG00000011632 18 - microtubule-associated protein 1 light chain 3 beta protein-coding - bta-miR-211 predicted by miR-204 (Homo sapiens),miR-204 (Rattus norvegicus), and MAP1LC3B predicted by Map1lc3b (Rattus norvegicus),MAP1LC3B (Homo sapiens) according to Pubmed ID (21316776),(21631941),(22516261),(25209181),(25517751) 4014 bta-miR-29d miR-29abcd MIMAT0009275 miRNA ATG9A autophagy down Bos taurus prediction 9913 540482 ATG9 BGD:BT13106|Ensembl:ENSBTAG00000020608 2 - ATG9 autophagy related 9 homolog A (S. cerevisiae) protein-coding - bta-miR-29d predicted by miR-29b (Bos taurus), and ATG9A predicted by ATG9A (Bos taurus) according to Pubmed ID (25234643) 4015 bta-miR-199a-5p miR-199ab-5p MIMAT0003544 miRNA BECN1 autophagy down Bos taurus prediction 9913 527278 ATG6 BGD:BT26123|Ensembl:ENSBTAG00000019914 19 - beclin 1, autophagy related protein-coding - bta-miR-199a-5p predicted by miR-199a-5p (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (23337876) 4016 bta-miR-302c miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0009281 miRNA ULK1 autophagy down Bos taurus prediction 9913 526310 - BGD:BT26556|Ensembl:ENSBTAG00000012987 17 - unc-51-like kinase 1 (C. elegans) protein-coding - bta-miR-302c predicted by miR-291 (Mus musculus), and ULK1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 4017 bta-miR-29d miR-29abcd MIMAT0009275 miRNA ATG14 autophagy down Bos taurus prediction 9913 538831 - BGD:BT20206|Ensembl:ENSBTAG00000010795 10 - ATG14 autophagy related 14 homolog (S. cerevisiae) protein-coding - bta-miR-29d predicted by miR-29b (Bos taurus), and ATG14 predicted by ATG14 (Bos taurus) according to Pubmed ID (25234643) 4018 bta-miR-30a-5p miR-30abcdef/30abe-5p/384-5p MIMAT0003841 miRNA BNIP3L autophagy down Bos taurus prediction 9913 534615 - BGD:BT17341|Ensembl:ENSBTAG00000021307 8 - BCL2/adenovirus E1B 19kDa interacting protein 3-like protein-coding - bta-miR-30a-5p predicted by miR-30d (Homo sapiens), and BNIP3L predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 4019 bta-let-7c let-7/98/4458/4500 MIMAT0004332 miRNA IGF1R autophagy down Bos taurus prediction 9913 281848 IGFR1 BGD:BT29334|Ensembl:ENSBTAG00000021527 21 - insulin-like growth factor 1 receptor protein-coding - bta-let-7c predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 4020 bta-miR-30b-5p miR-30abcdef/30abe-5p/384-5p MIMAT0003547 miRNA BNIP3L autophagy down Bos taurus prediction 9913 534615 - BGD:BT17341|Ensembl:ENSBTAG00000021307 8 - BCL2/adenovirus E1B 19kDa interacting protein 3-like protein-coding - bta-miR-30b-5p predicted by miR-30d (Homo sapiens), and BNIP3L predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 4021 bta-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003796 miRNA ATG7 autophagy down Bos taurus prediction 9913 787967 - Ensembl:ENSBTAG00000035827 22 - autophagy related 7 protein-coding - bta-miR-20b predicted by miR-17 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 4022 bta-miR-449a miR-34ac/34bc-5p/449abc/449c-5p MIMAT0009320 miRNA ATG4B autophagy down Bos taurus prediction 9913 408002 Aut2b2 Ensembl:ENSBTAG00000015401 3 - autophagy related 4B, cysteine peptidase protein-coding - bta-miR-449a predicted by miR-34a (Homo sapiens), and ATG4B predicted by ATG4B (Homo sapiens) according to Pubmed ID (24755409) 4023 bta-miR-497 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0004343 miRNA ATG5 autophagy down Bos taurus prediction 9913 532686 - BGD:BT28451|Ensembl:ENSBTAG00000005400 9 - ATG5 autophagy related 5 homolog (S. cerevisiae) protein-coding - bta-miR-497 predicted by miR-16 (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (23143396) 4024 bta-miR-130a miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0009223 miRNA FYCO1 autophagy down Bos taurus prediction 9913 100139246 - BGD:BT30103|Ensembl:ENSBTAG00000015698 22 - FYVE and coiled-coil domain containing 1 protein-coding - bta-miR-130a predicted by miR-130b (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 4025 bta-miR-199b miR-199ab-5p MIMAT0003821 miRNA HSPA5 autophagy down Bos taurus prediction 9913 415113 grp78 - 11 - heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) protein-coding - bta-miR-199b predicted by miR-199a-5p (Mus musculus), and HSPA5 predicted by Hspa5 (Mus musculus) according to Pubmed ID (23598416) 4026 bta-miR-34b miR-34ac/34bc-5p/449abc/449c-5p MIMAT0003549 miRNA ATG4B autophagy down Bos taurus prediction 9913 408002 Aut2b2 Ensembl:ENSBTAG00000015401 3 - autophagy related 4B, cysteine peptidase protein-coding - bta-miR-34b predicted by miR-34a (Homo sapiens), and ATG4B predicted by ATG4B (Homo sapiens) according to Pubmed ID (24755409) 4027 bta-miR-302c miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0009281 miRNA FYCO1 autophagy down Bos taurus prediction 9913 100139246 - BGD:BT30103|Ensembl:ENSBTAG00000015698 22 - FYVE and coiled-coil domain containing 1 protein-coding - bta-miR-302c predicted by miR-373 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 4028 bta-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0009218 miRNA ULK1 autophagy down Bos taurus prediction 9913 526310 - BGD:BT26556|Ensembl:ENSBTAG00000012987 17 - unc-51-like kinase 1 (C. elegans) protein-coding - bta-miR-106b predicted by miR-106b (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 4029 bta-miR-204 miR-204/204b/211 MIMAT0004338 miRNA MAP1LC3B autophagy down Bos taurus prediction 9913 408001 - BGD:BT25974|Ensembl:ENSBTAG00000011632 18 - microtubule-associated protein 1 light chain 3 beta protein-coding - bta-miR-204 predicted by miR-204 (Homo sapiens),miR-204 (Rattus norvegicus), and MAP1LC3B predicted by Map1lc3b (Rattus norvegicus),MAP1LC3B (Homo sapiens) according to Pubmed ID (21316776),(21631941),(22516261),(25209181),(25517751) 4030 bta-miR-15a miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0004334 miRNA ATG5 autophagy down Bos taurus prediction 9913 532686 - BGD:BT28451|Ensembl:ENSBTAG00000005400 9 - ATG5 autophagy related 5 homolog (S. cerevisiae) protein-coding - bta-miR-15a predicted by miR-16 (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (23143396) 4031 bta-miR-106 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003784 miRNA ULK1 autophagy down Bos taurus prediction 9913 526310 - BGD:BT26556|Ensembl:ENSBTAG00000012987 17 - unc-51-like kinase 1 (C. elegans) protein-coding - bta-miR-106 predicted by miR-106b (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 4032 bta-miR-148a miR-148ab-3p/152 MIMAT0003522 miRNA ATG14 autophagy down Bos taurus prediction 9913 538831 - BGD:BT20206|Ensembl:ENSBTAG00000010795 10 - ATG14 autophagy related 14 homolog (S. cerevisiae) protein-coding - bta-miR-148a predicted by miR-152 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (25650716) 4033 bta-miR-30f miR-30abcdef/30abe-5p/384-5p MIMAT0009282 miRNA ATG12 autophagy down Bos taurus prediction 9913 767903 - BGD:BT29631|Ensembl:ENSBTAG00000017525 10 - ATG12 autophagy related 12 homolog (S. cerevisiae) protein-coding - bta-miR-30f predicted by miR-30b (Homo sapiens), and ATG12 predicted by ATG12 (Homo sapiens) according to Pubmed ID (22647547),(23274497) 4034 bta-miR-16b miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0003525 miRNA ATG5 autophagy down Bos taurus prediction 9913 532686 - BGD:BT28451|Ensembl:ENSBTAG00000005400 9 - ATG5 autophagy related 5 homolog (S. cerevisiae) protein-coding - bta-miR-16b predicted by miR-16 (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (23143396) 4035 bta-miR-182 miR-182 MIMAT0009244 miRNA FOXO3 autophagy down Bos taurus prediction 9913 535530 FOXO-3 BGD:BT12225|Ensembl:ENSBTAG00000011234 9 - forkhead box O3 protein-coding - bta-miR-182 predicted by miR-182 (Homo sapiens), and FOXO3 predicted by FOXO3 (Homo sapiens) according to Pubmed ID (24871856) 4036 bta-miR-30e-5p miR-30abcdef/30abe-5p/384-5p MIMAT0003799 miRNA BNIP3L autophagy down Bos taurus prediction 9913 534615 - BGD:BT17341|Ensembl:ENSBTAG00000021307 8 - BCL2/adenovirus E1B 19kDa interacting protein 3-like protein-coding - bta-miR-30e-5p predicted by miR-30d (Homo sapiens), and BNIP3L predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 4037 bta-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003527 miRNA FYCO1 autophagy down Bos taurus prediction 9913 100139246 - BGD:BT30103|Ensembl:ENSBTAG00000015698 22 - FYVE and coiled-coil domain containing 1 protein-coding - bta-miR-20a predicted by miR-93 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 4038 bta-miR-302d miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0009279 miRNA SQSTM1 autophagy down Bos taurus prediction 9913 338045 - BGD:BT16900|Ensembl:ENSBTAG00000015591 7 - sequestosome 1 protein-coding - bta-miR-302d predicted by miR-372 (Homo sapiens), and SQSTM1 predicted by SQSTM1 (Homo sapiens) according to Pubmed ID (24991827) 4039 bta-miR-30d miR-30abcdef/30abe-5p/384-5p MIMAT0003533 miRNA BNIP3L autophagy down Bos taurus prediction 9913 534615 - BGD:BT17341|Ensembl:ENSBTAG00000021307 8 - BCL2/adenovirus E1B 19kDa interacting protein 3-like protein-coding - bta-miR-30d predicted by miR-30d (Homo sapiens), and BNIP3L predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 4040 bta-miR-211 miR-204/204b/211 MIMAT0009263 miRNA VHL autophagy down Bos taurus prediction 9913 540957 - BGD:BT18018|Ensembl:ENSBTAG00000016101 22 - von Hippel-Lindau tumor suppressor protein-coding - bta-miR-211 predicted by miR-204 (Homo sapiens), and VHL predicted by VHL (Homo sapiens) according to Pubmed ID (25517751) 4041 bta-miR-92a miR-25/32/92abc/363/363-3p/367 MIMAT0009383 miRNA UVRAG autophagy down Bos taurus prediction 9913 614285 - BGD:BT19521|Ensembl:ENSBTAG00000016355 15 - UV radiation resistance associated gene protein-coding - bta-miR-92a predicted by miR-32 (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22135297) 4042 bta-miR-449a miR-34ac/34bc-5p/449abc/449c-5p MIMAT0009320 miRNA ATG9A autophagy down Bos taurus prediction 9913 540482 ATG9 BGD:BT13106|Ensembl:ENSBTAG00000020608 2 - ATG9 autophagy related 9 homolog A (S. cerevisiae) protein-coding - bta-miR-449a predicted by miR-34a (Homo sapiens),miR-34a (Rattus norvegicus), and ATG9A predicted by Atg9a (Rattus norvegicus),ATG9A (Homo sapiens) according to Pubmed ID (22902544),(24728149),(24973144) 4043 bta-miR-24-3p miR-24/24ab/24-3p MIMAT0003840 miRNA ATG4A autophagy down Bos taurus prediction 9913 408003 Aut2a BGD:BT21225|Ensembl:ENSBTAG00000013724 X - ATG4 autophagy related 4 homolog A (S. cerevisiae) protein-coding - bta-miR-24-3p predicted by miR-24-3p (Homo sapiens), and ATG4A predicted by ATG4A (Homo sapiens) according to Pubmed ID (25426560) 4044 bta-let-7g let-7/98/4458/4500 MIMAT0003838 miRNA IGF1R autophagy down Bos taurus prediction 9913 281848 IGFR1 BGD:BT29334|Ensembl:ENSBTAG00000021527 21 - insulin-like growth factor 1 receptor protein-coding - bta-let-7g predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 4045 bta-miR-96 miR-96/507/1271 MIMAT0009388 miRNA ATG7 autophagy down Bos taurus prediction 9913 787967 - Ensembl:ENSBTAG00000035827 22 - autophagy related 7 protein-coding - bta-miR-96 predicted by miR-96 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (25333253) 4046 bta-miR-199a-5p miR-199ab-5p MIMAT0003544 miRNA HSPA5 autophagy down Bos taurus prediction 9913 415113 grp78 - 11 - heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) protein-coding - bta-miR-199a-5p predicted by miR-199a-5p (Mus musculus), and HSPA5 predicted by Hspa5 (Mus musculus) according to Pubmed ID (23598416) 4047 bta-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003796 miRNA ATG5 autophagy down Bos taurus prediction 9913 532686 - BGD:BT28451|Ensembl:ENSBTAG00000005400 9 - ATG5 autophagy related 5 homolog (S. cerevisiae) protein-coding - bta-miR-20b predicted by miR-20a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (25485521) 4048 bta-miR-30f miR-30abcdef/30abe-5p/384-5p MIMAT0009282 miRNA BNIP3L autophagy down Bos taurus prediction 9913 534615 - BGD:BT17341|Ensembl:ENSBTAG00000021307 8 - BCL2/adenovirus E1B 19kDa interacting protein 3-like protein-coding - bta-miR-30f predicted by miR-30d (Homo sapiens), and BNIP3L predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 4049 bta-miR-155 miR-155 MIMAT0009241 miRNA RHEB autophagy down Bos taurus prediction 9913 528204 - Ensembl:ENSBTAG00000031861 4 - Ras homolog enriched in brain protein-coding - bta-miR-155 predicted by miR-155 (Homo sapiens), and RHEB predicted by RHEB (Homo sapiens) according to Pubmed ID (24130493),(24262949) 4050 bta-miR-181b miR-181abcd/4262 MIMAT0003793 miRNA TP63 autophagy down Bos taurus prediction 9913 615335 - BGD:BT10014|Ensembl:ENSBTAG00000015460 1 - tumor protein p63 protein-coding - bta-miR-181b predicted by miR-181a (Homo sapiens), and TP63 predicted by TP63 (Homo sapiens) according to Pubmed ID (22356768) 4051 bta-miR-17-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003815 miRNA HIF1A autophagy down Bos taurus prediction 9913 281814 - BGD:BT12172|Ensembl:ENSBTAG00000020935 10 - hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding - bta-miR-17-5p predicted by miR-20a (Homo sapiens), and HIF1A predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 4052 bta-miR-93 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003837 miRNA ATG16L1 autophagy down Bos taurus prediction 9913 509587 - BGD:BT16113|Ensembl:ENSBTAG00000003928 3 - ATG16 autophagy related 16-like 1 (S. cerevisiae) protein-coding - bta-miR-93 predicted by miR-106b (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 4053 bta-miR-30b-5p miR-30abcdef/30abe-5p/384-5p MIMAT0003547 miRNA ATG5 autophagy down Bos taurus prediction 9913 532686 - BGD:BT28451|Ensembl:ENSBTAG00000005400 9 - ATG5 autophagy related 5 homolog (S. cerevisiae) protein-coding - bta-miR-30b-5p predicted by miR-30a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22395361),(22617440),(22902544),(23274497),(24148619) 4054 bta-miR-23b-3p miR-23abc/23b-3p MIMAT0003852 miRNA ATG12 autophagy down Bos taurus prediction 9913 767903 - BGD:BT29631|Ensembl:ENSBTAG00000017525 10 - ATG12 autophagy related 12 homolog (S. cerevisiae) protein-coding - bta-miR-23b-3p predicted by miR-23b (Homo sapiens), and ATG12 predicted by ATG12 (Homo sapiens) according to Pubmed ID (23916944),(24145177) 4055 bta-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003527 miRNA HIF1A autophagy down Bos taurus prediction 9913 281814 - BGD:BT12172|Ensembl:ENSBTAG00000020935 10 - hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding - bta-miR-20a predicted by miR-20a (Homo sapiens), and HIF1A predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 4056 bta-miR-132 miR-132/212/212-3p MIMAT0003812 miRNA FOXO3 autophagy down Bos taurus prediction 9913 535530 FOXO-3 BGD:BT12225|Ensembl:ENSBTAG00000011234 9 - forkhead box O3 protein-coding - bta-miR-132 predicted by miR-132 (Mus musculus), and FOXO3 predicted by Foxo3 (Mus musculus) according to Pubmed ID (23011132) 4057 bta-miR-30f miR-30abcdef/30abe-5p/384-5p MIMAT0009282 miRNA ATG5 autophagy down Bos taurus prediction 9913 532686 - BGD:BT28451|Ensembl:ENSBTAG00000005400 9 - ATG5 autophagy related 5 homolog (S. cerevisiae) protein-coding - bta-miR-30f predicted by miR-30a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22395361),(22617440),(22902544),(23274497),(24148619) 4058 bta-miR-15a miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0004334 miRNA BAG5 autophagy down Bos taurus prediction 9913 522854 - BGD:BT25018|Ensembl:ENSBTAG00000017361 21 - BCL2-associated athanogene 5 protein-coding - bta-miR-15a predicted by miR-16 (Mus musculus), and BAG5 predicted by Bag5 (Mus musculus) according to Pubmed ID (21770019) 4059 bta-miR-34a miR-34ac/34bc-5p/449abc/449c-5p MIMAT0004340 miRNA ATG4B autophagy down Bos taurus prediction 9913 408002 Aut2b2 Ensembl:ENSBTAG00000015401 3 - autophagy related 4B, cysteine peptidase protein-coding - bta-miR-34a predicted by miR-34a (Homo sapiens), and ATG4B predicted by ATG4B (Homo sapiens) according to Pubmed ID (24755409) 4060 bta-miR-221 miR-221/222/222ab/1928 MIMAT0003529 miRNA CDKN1B autophagy down Bos taurus prediction 9913 512613 - BGD:BT28157|Ensembl:ENSBTAG00000018254 5 - cyclin-dependent kinase inhibitor 1B (p27, Kip1) protein-coding - bta-miR-221 predicted by miR-221 (Homo sapiens), and CDKN1B predicted by CDKN1B (Homo sapiens) according to Pubmed ID (25394488) 4061 bta-miR-144 miR-144 MIMAT0009234 miRNA MTOR autophagy down Bos taurus prediction 9913 100139219 - BGD:BT29876|Ensembl:ENSBTAG00000015325 16 - mechanistic target of rapamycin (serine/threonine kinase) protein-coding - bta-miR-144 predicted by miR-144 (Homo sapiens), and MTOR predicted by MTOR (Homo sapiens) according to Pubmed ID (25060662) 4062 bta-miR-130a miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0009223 miRNA ATG2B autophagy down Bos taurus prediction 9913 519961 - Ensembl:ENSBTAG00000012833 21 - autophagy related 2B protein-coding - bta-miR-130a predicted by miR-130a (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (22902544) 4063 bta-miR-93 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003837 miRNA BECN1 autophagy down Bos taurus prediction 9913 527278 ATG6 BGD:BT26123|Ensembl:ENSBTAG00000019914 19 - beclin 1, autophagy related protein-coding - bta-miR-93 predicted by miR-17-5p (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (24755562),(25435430),(25485521) 4064 bta-miR-34c miR-34ac/34bc-5p/449abc/449c-5p MIMAT0003854 miRNA ATG9A autophagy down Bos taurus prediction 9913 540482 ATG9 BGD:BT13106|Ensembl:ENSBTAG00000020608 2 - ATG9 autophagy related 9 homolog A (S. cerevisiae) protein-coding - bta-miR-34c predicted by miR-34a (Homo sapiens),miR-34a (Rattus norvegicus), and ATG9A predicted by Atg9a (Rattus norvegicus),ATG9A (Homo sapiens) according to Pubmed ID (22902544),(24728149),(24973144) 4065 bta-miR-424 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0013593 miRNA BCL2L2 autophagy down Bos taurus prediction 9913 767601 - BGD:BT13347|Ensembl:ENSBTAG00000019692 10 - BCL2-like 2 protein-coding - bta-miR-424 predicted by miR-15b (Mus musculus), and BCL2L2 predicted by Bcl2l2 (Mus musculus) according to Pubmed ID (21770019) 4066 bta-miR-302b miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0009280 miRNA FYCO1 autophagy down Bos taurus prediction 9913 100139246 - BGD:BT30103|Ensembl:ENSBTAG00000015698 22 - FYVE and coiled-coil domain containing 1 protein-coding - bta-miR-302b predicted by miR-373 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 4067 bta-miR-181d miR-181abcd/4262 MIMAT0009243 miRNA TP63 autophagy down Bos taurus prediction 9913 615335 - BGD:BT10014|Ensembl:ENSBTAG00000015460 1 - tumor protein p63 protein-coding - bta-miR-181d predicted by miR-181a (Homo sapiens), and TP63 predicted by TP63 (Homo sapiens) according to Pubmed ID (22356768) 4068 bta-miR-182 miR-182 MIMAT0009244 miRNA BCL2 autophagy down Bos taurus prediction 9913 281020 - BGD:BT11029|Ensembl:ENSBTAG00000019302 24 - B-cell CLL/lymphoma 2 protein-coding - bta-miR-182 predicted by miR-182 (Homo sapiens), and BCL2 predicted by BCL2 (Homo sapiens) according to Pubmed ID (23936432) 4069 bta-miR-100 miR-99ab/100 MIMAT0009215 miRNA IGF1R autophagy down Bos taurus prediction 9913 281848 IGFR1 BGD:BT29334|Ensembl:ENSBTAG00000021527 21 - insulin-like growth factor 1 receptor protein-coding - bta-miR-100 predicted by miR-100 (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25026290) 4070 bta-miR-30b-5p miR-30abcdef/30abe-5p/384-5p MIMAT0003547 miRNA BECN1 autophagy down Bos taurus prediction 9913 527278 ATG6 BGD:BT26123|Ensembl:ENSBTAG00000019914 19 - beclin 1, autophagy related protein-coding - bta-miR-30b-5p predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and BECN1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 4071 bta-miR-181b miR-181abcd/4262 MIMAT0003793 miRNA ATG5 autophagy down Bos taurus prediction 9913 532686 - BGD:BT28451|Ensembl:ENSBTAG00000005400 9 - ATG5 autophagy related 5 homolog (S. cerevisiae) protein-coding - bta-miR-181b predicted by miR-181a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22356768),(22902544),(23322078) 4072 bta-miR-454 miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0009326 miRNA FYCO1 autophagy down Bos taurus prediction 9913 100139246 - BGD:BT30103|Ensembl:ENSBTAG00000015698 22 - FYVE and coiled-coil domain containing 1 protein-coding - bta-miR-454 predicted by miR-130b (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 4073 bta-miR-29c miR-29abcd MIMAT0003829 miRNA ATG14 autophagy down Bos taurus prediction 9913 538831 - BGD:BT20206|Ensembl:ENSBTAG00000010795 10 - ATG14 autophagy related 14 homolog (S. cerevisiae) protein-coding - bta-miR-29c predicted by miR-29b (Bos taurus), and ATG14 predicted by ATG14 (Bos taurus) according to Pubmed ID (25234643) 4074 bta-miR-497 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0004343 miRNA BAG5 autophagy down Bos taurus prediction 9913 522854 - BGD:BT25018|Ensembl:ENSBTAG00000017361 21 - BCL2-associated athanogene 5 protein-coding - bta-miR-497 predicted by miR-16 (Mus musculus), and BAG5 predicted by Bag5 (Mus musculus) according to Pubmed ID (21770019) 4075 bta-miR-100 miR-99ab/100 MIMAT0009215 miRNA MTOR autophagy down Bos taurus prediction 9913 100139219 - BGD:BT29876|Ensembl:ENSBTAG00000015325 16 - mechanistic target of rapamycin (serine/threonine kinase) protein-coding - bta-miR-100 predicted by miR-100 (Homo sapiens), and MTOR predicted by MTOR (Homo sapiens) according to Pubmed ID (25026290) 4076 bta-miR-22-3p miR-22/22-3p MIMAT0012536 miRNA BTG1 autophagy down Bos taurus prediction 9913 281032 - BGD:BT21038|Ensembl:ENSBTAG00000020330 5 - B-cell translocation gene 1, anti-proliferative protein-coding - bta-miR-22-3p predicted by miR-22 (Homo sapiens), and BTG1 predicted by BTG1 (Homo sapiens) according to Pubmed ID (25449431) 4077 bta-miR-424 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0013593 miRNA BAG5 autophagy down Bos taurus prediction 9913 522854 - BGD:BT25018|Ensembl:ENSBTAG00000017361 21 - BCL2-associated athanogene 5 protein-coding - bta-miR-424 predicted by miR-16 (Mus musculus), and BAG5 predicted by Bag5 (Mus musculus) according to Pubmed ID (21770019) 4078 bta-miR-92 miR-25/32/92abc/363/363-3p/367 MIMAT0003808 miRNA UVRAG autophagy down Bos taurus prediction 9913 614285 - BGD:BT19521|Ensembl:ENSBTAG00000016355 15 - UV radiation resistance associated gene protein-coding - bta-miR-92 predicted by miR-32 (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22135297) 4079 bta-miR-93 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003837 miRNA ATG7 autophagy down Bos taurus prediction 9913 787967 - Ensembl:ENSBTAG00000035827 22 - autophagy related 7 protein-coding - bta-miR-93 predicted by miR-17 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 4080 bta-miR-204 miR-204/204b/211 MIMAT0004338 miRNA CAV1 autophagy down Bos taurus prediction 9913 281040 - BGD:BT10178|Ensembl:ENSBTAG00000017869 4 - caveolin 1, caveolae protein, 22kDa protein-coding - bta-miR-204 predicted by miR-204 (Homo sapiens), and CAV1 predicted by CAV1 (Homo sapiens) according to Pubmed ID (25517751) 4081 bta-miR-181a miR-181abcd/4262 MIMAT0003543 miRNA TP63 autophagy down Bos taurus prediction 9913 615335 - BGD:BT10014|Ensembl:ENSBTAG00000015460 1 - tumor protein p63 protein-coding - bta-miR-181a predicted by miR-181a (Homo sapiens), and TP63 predicted by TP63 (Homo sapiens) according to Pubmed ID (22356768) 4082 bta-miR-29b miR-29abcd MIMAT0003828 miRNA PSME4 autophagy down Bos taurus prediction 9913 528142 - BGD:BT15703|Ensembl:ENSBTAG00000020262 11 - proteasome (prosome, macropain) activator subunit 4 protein-coding - bta-miR-29b predicted by miR-29b (Homo sapiens), and PSME4 predicted by PSME4 (Homo sapiens) according to Pubmed ID (25234165) 4083 bta-let-7f let-7/98/4458/4500 MIMAT0003519 miRNA MTOR autophagy down Bos taurus prediction 9913 100139219 - BGD:BT29876|Ensembl:ENSBTAG00000015325 16 - mechanistic target of rapamycin (serine/threonine kinase) protein-coding - bta-let-7f predicted by let-7 (Homo sapiens), and MTOR predicted by MTOR (Homo sapiens) according to Pubmed ID (25295787) 4084 bta-miR-16a miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0009242 miRNA BCL2L2 autophagy down Bos taurus prediction 9913 767601 - BGD:BT13347|Ensembl:ENSBTAG00000019692 10 - BCL2-like 2 protein-coding - bta-miR-16a predicted by miR-15b (Mus musculus), and BCL2L2 predicted by Bcl2l2 (Mus musculus) according to Pubmed ID (21770019) 4085 bta-miR-302d miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0009279 miRNA FYCO1 autophagy down Bos taurus prediction 9913 100139246 - BGD:BT30103|Ensembl:ENSBTAG00000015698 22 - FYVE and coiled-coil domain containing 1 protein-coding - bta-miR-302d predicted by miR-373 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 4086 bta-miR-144 miR-144 MIMAT0009234 miRNA C5H12orf5 autophagy down Bos taurus prediction 9913 615392 TIGAR Ensembl:ENSBTAG00000016650 5 - chromosome 5 open reading frame, human C12orf5 protein-coding - bta-miR-144 predicted by miR-144 (Homo sapiens), and C5H12orf5 predicted by C12orf5 (Homo sapiens) according to Pubmed ID (25660220) 4087 bta-miR-34b miR-34ac/34bc-5p/449abc/449c-5p MIMAT0003549 miRNA ATG9A autophagy down Bos taurus prediction 9913 540482 ATG9 BGD:BT13106|Ensembl:ENSBTAG00000020608 2 - ATG9 autophagy related 9 homolog A (S. cerevisiae) protein-coding - bta-miR-34b predicted by miR-34a (Homo sapiens),miR-34a (Rattus norvegicus), and ATG9A predicted by Atg9a (Rattus norvegicus),ATG9A (Homo sapiens) according to Pubmed ID (22902544),(24728149),(24973144) 4088 bta-miR-106 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003784 miRNA HIF1A autophagy down Bos taurus prediction 9913 281814 - BGD:BT12172|Ensembl:ENSBTAG00000020935 10 - hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding - bta-miR-106 predicted by miR-20a (Homo sapiens), and HIF1A predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 4089 bta-miR-34c miR-34ac/34bc-5p/449abc/449c-5p MIMAT0003854 miRNA ATG4B autophagy down Bos taurus prediction 9913 408002 Aut2b2 Ensembl:ENSBTAG00000015401 3 - autophagy related 4B, cysteine peptidase protein-coding - bta-miR-34c predicted by miR-34a (Homo sapiens), and ATG4B predicted by ATG4B (Homo sapiens) according to Pubmed ID (24755409) 4090 bta-miR-204 miR-204/204b/211 MIMAT0004338 miRNA VHL autophagy down Bos taurus prediction 9913 540957 - BGD:BT18018|Ensembl:ENSBTAG00000016101 22 - von Hippel-Lindau tumor suppressor protein-coding - bta-miR-204 predicted by miR-204 (Homo sapiens), and VHL predicted by VHL (Homo sapiens) according to Pubmed ID (25517751) 4091 bta-miR-106 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003784 miRNA SQSTM1 autophagy down Bos taurus prediction 9913 338045 - BGD:BT16900|Ensembl:ENSBTAG00000015591 7 - sequestosome 1 protein-coding - bta-miR-106 predicted by miR-106b (Homo sapiens),miR-106 (Mus musculus), and SQSTM1 predicted by Sqstm1 (Mus musculus),SQSTM1 (Homo sapiens) according to Pubmed ID (21628417),(22441107),(25485521),(25617127) 4092 bta-miR-216a miR-216a MIMAT0009265 miRNA BECN1 autophagy down Bos taurus prediction 9913 527278 ATG6 BGD:BT26123|Ensembl:ENSBTAG00000019914 19 - beclin 1, autophagy related protein-coding - bta-miR-216a predicted by miR-216a (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (24481443) 4093 bta-let-7i let-7/98/4458/4500 MIMAT0003851 miRNA MTOR autophagy down Bos taurus prediction 9913 100139219 - BGD:BT29876|Ensembl:ENSBTAG00000015325 16 - mechanistic target of rapamycin (serine/threonine kinase) protein-coding - bta-let-7i predicted by let-7 (Homo sapiens), and MTOR predicted by MTOR (Homo sapiens) according to Pubmed ID (25295787) 4094 bta-miR-152 miR-148ab-3p/152 MIMAT0009238 miRNA ATG14 autophagy down Bos taurus prediction 9913 538831 - BGD:BT20206|Ensembl:ENSBTAG00000010795 10 - ATG14 autophagy related 14 homolog (S. cerevisiae) protein-coding - bta-miR-152 predicted by miR-152 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (25650716) 4095 bta-miR-181c miR-181abcd/4262 MIMAT0003817 miRNA ATG5 autophagy down Bos taurus prediction 9913 532686 - BGD:BT28451|Ensembl:ENSBTAG00000005400 9 - ATG5 autophagy related 5 homolog (S. cerevisiae) protein-coding - bta-miR-181c predicted by miR-181a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22356768),(22902544),(23322078) 4096 bta-let-7e let-7/98/4458/4500 MIMAT0004333 miRNA MTOR autophagy down Bos taurus prediction 9913 100139219 - BGD:BT29876|Ensembl:ENSBTAG00000015325 16 - mechanistic target of rapamycin (serine/threonine kinase) protein-coding - bta-let-7e predicted by let-7 (Homo sapiens), and MTOR predicted by MTOR (Homo sapiens) according to Pubmed ID (25295787) 4097 bta-miR-449b miR-34ac/34bc-5p/449abc/449c-5p MIMAT0009321 miRNA ATG4B autophagy down Bos taurus prediction 9913 408002 Aut2b2 Ensembl:ENSBTAG00000015401 3 - autophagy related 4B, cysteine peptidase protein-coding - bta-miR-449b predicted by miR-34a (Homo sapiens), and ATG4B predicted by ATG4B (Homo sapiens) according to Pubmed ID (24755409) 4098 bta-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003796 miRNA BECN1 autophagy down Bos taurus prediction 9913 527278 ATG6 BGD:BT26123|Ensembl:ENSBTAG00000019914 19 - beclin 1, autophagy related protein-coding - bta-miR-20b predicted by miR-17-5p (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (24755562),(25435430),(25485521) 4099 bta-miR-30b-5p miR-30abcdef/30abe-5p/384-5p MIMAT0003547 miRNA ATG12 autophagy down Bos taurus prediction 9913 767903 - BGD:BT29631|Ensembl:ENSBTAG00000017525 10 - ATG12 autophagy related 12 homolog (S. cerevisiae) protein-coding - bta-miR-30b-5p predicted by miR-30b (Homo sapiens), and ATG12 predicted by ATG12 (Homo sapiens) according to Pubmed ID (22647547),(23274497) 4100 bta-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003527 miRNA ULK1 autophagy down Bos taurus prediction 9913 526310 - BGD:BT26556|Ensembl:ENSBTAG00000012987 17 - unc-51-like kinase 1 (C. elegans) protein-coding - bta-miR-20a predicted by miR-106b (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 4101 bta-miR-21 miR-21/590-5p MIMAT0003528 miRNA BCL2 autophagy down Bos taurus prediction 9913 281020 - BGD:BT11029|Ensembl:ENSBTAG00000019302 24 - B-cell CLL/lymphoma 2 protein-coding - bta-miR-21 predicted by miR-21 (Homo sapiens), and BCL2 predicted by BCL2 (Homo sapiens) according to Pubmed ID (23834154) 4102 bta-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003527 miRNA SQSTM1 autophagy down Bos taurus prediction 9913 338045 - BGD:BT16900|Ensembl:ENSBTAG00000015591 7 - sequestosome 1 protein-coding - bta-miR-20a predicted by miR-106b (Homo sapiens),miR-106 (Mus musculus), and SQSTM1 predicted by Sqstm1 (Mus musculus),SQSTM1 (Homo sapiens) according to Pubmed ID (21628417),(22441107),(25485521),(25617127) 4103 bta-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003527 miRNA ATG16L1 autophagy down Bos taurus prediction 9913 509587 - BGD:BT16113|Ensembl:ENSBTAG00000003928 3 - ATG16 autophagy related 16-like 1 (S. cerevisiae) protein-coding - bta-miR-20a predicted by miR-106b (Homo sapiens), and ATG16L1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 4104 bta-miR-93 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003837 miRNA SQSTM1 autophagy down Bos taurus prediction 9913 338045 - BGD:BT16900|Ensembl:ENSBTAG00000015591 7 - sequestosome 1 protein-coding - bta-miR-93 predicted by miR-106b (Homo sapiens),miR-106 (Mus musculus), and SQSTM1 predicted by Sqstm1 (Mus musculus),SQSTM1 (Homo sapiens) according to Pubmed ID (21628417),(22441107),(25485521),(25617127) 4105 bta-miR-101 miR-101/101ab MIMAT0003520 miRNA STMN1 autophagy down Bos taurus prediction 9913 616317 - BGD:BT21052|Ensembl:ENSBTAG00000013761 2 - stathmin 1 protein-coding - bta-miR-101 predicted by miR-101 (Homo sapiens), and STMN1 predicted by STMN1 (Homo sapiens) according to Pubmed ID (21915098),(23483142),(25607713) 4106 bta-miR-1271 miR-96/507/1271 MIMAT0009975 miRNA MTOR autophagy down Bos taurus prediction 9913 100139219 - BGD:BT29876|Ensembl:ENSBTAG00000015325 16 - mechanistic target of rapamycin (serine/threonine kinase) protein-coding - bta-miR-1271 predicted by miR-96 (Homo sapiens), and MTOR predicted by MTOR (Homo sapiens) according to Pubmed ID (25333253) 4107 bta-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003796 miRNA FYCO1 autophagy down Bos taurus prediction 9913 100139246 - BGD:BT30103|Ensembl:ENSBTAG00000015698 22 - FYVE and coiled-coil domain containing 1 protein-coding - bta-miR-20b predicted by miR-93 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 4108 bta-miR-93 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003837 miRNA ULK1 autophagy down Bos taurus prediction 9913 526310 - BGD:BT26556|Ensembl:ENSBTAG00000012987 17 - unc-51-like kinase 1 (C. elegans) protein-coding - bta-miR-93 predicted by miR-106b (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 4109 bta-miR-200b miR-200bc/429/548a MIMAT0003842 miRNA UBQLN1 autophagy down Bos taurus prediction 9913 282392 - Ensembl:ENSBTAG00000014827 8 - ubiquilin 1 protein-coding - bta-miR-200b predicted by miR-200c (Homo sapiens), and UBQLN1 predicted by UBQLN1 (Homo sapiens) according to Pubmed ID (25044403) 4110 bta-let-7d let-7/98/4458/4500 MIMAT0003810 miRNA IGF1R autophagy down Bos taurus prediction 9913 281848 IGFR1 BGD:BT29334|Ensembl:ENSBTAG00000021527 21 - insulin-like growth factor 1 receptor protein-coding - bta-let-7d predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 4111 bta-miR-30d miR-30abcdef/30abe-5p/384-5p MIMAT0003533 miRNA ATG5 autophagy down Bos taurus prediction 9913 532686 - BGD:BT28451|Ensembl:ENSBTAG00000005400 9 - ATG5 autophagy related 5 homolog (S. cerevisiae) protein-coding - bta-miR-30d predicted by miR-30a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22395361),(22617440),(22902544),(23274497),(24148619) 4112 bta-miR-106 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003784 miRNA BECN1 autophagy down Bos taurus prediction 9913 527278 ATG6 BGD:BT26123|Ensembl:ENSBTAG00000019914 19 - beclin 1, autophagy related protein-coding - bta-miR-106 predicted by miR-17-5p (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (24755562),(25435430),(25485521) 4113 bta-miR-155 miR-155 MIMAT0009241 miRNA GSK3B autophagy down Bos taurus prediction 9913 790875 GSK3beta - 1 - glycogen synthase kinase 3 beta protein-coding - bta-miR-155 predicted by miR-155 (Homo sapiens), and GSK3B predicted by GSK3B (Homo sapiens) according to Pubmed ID (24343269) 4114 bta-miR-34a miR-34ac/34bc-5p/449abc/449c-5p MIMAT0004340 miRNA ATG9A autophagy down Bos taurus prediction 9913 540482 ATG9 BGD:BT13106|Ensembl:ENSBTAG00000020608 2 - ATG9 autophagy related 9 homolog A (S. cerevisiae) protein-coding - bta-miR-34a predicted by miR-34a (Homo sapiens),miR-34a (Rattus norvegicus), and ATG9A predicted by Atg9a (Rattus norvegicus),ATG9A (Homo sapiens) according to Pubmed ID (22902544),(24728149),(24973144) 4115 bta-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003796 miRNA SQSTM1 autophagy down Bos taurus prediction 9913 338045 - BGD:BT16900|Ensembl:ENSBTAG00000015591 7 - sequestosome 1 protein-coding - bta-miR-20b predicted by miR-106b (Homo sapiens),miR-106 (Mus musculus), and SQSTM1 predicted by Sqstm1 (Mus musculus),SQSTM1 (Homo sapiens) according to Pubmed ID (21628417),(22441107),(25485521),(25617127) 4116 bta-miR-497 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0004343 miRNA BCL2L2 autophagy down Bos taurus prediction 9913 767601 - BGD:BT13347|Ensembl:ENSBTAG00000019692 10 - BCL2-like 2 protein-coding - bta-miR-497 predicted by miR-15b (Mus musculus), and BCL2L2 predicted by Bcl2l2 (Mus musculus) according to Pubmed ID (21770019) 4117 bta-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003527 miRNA BECN1 autophagy down Bos taurus prediction 9913 527278 ATG6 BGD:BT26123|Ensembl:ENSBTAG00000019914 19 - beclin 1, autophagy related protein-coding - bta-miR-20a predicted by miR-17-5p (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (24755562),(25435430),(25485521) 4118 bta-let-7b let-7/98/4458/4500 MIMAT0004331 miRNA IGF1R autophagy down Bos taurus prediction 9913 281848 IGFR1 BGD:BT29334|Ensembl:ENSBTAG00000021527 21 - insulin-like growth factor 1 receptor protein-coding - bta-let-7b predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 4119 bta-miR-130b miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0009224 miRNA FYCO1 autophagy down Bos taurus prediction 9913 100139246 - BGD:BT30103|Ensembl:ENSBTAG00000015698 22 - FYVE and coiled-coil domain containing 1 protein-coding - bta-miR-130b predicted by miR-130b (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 4120 bta-miR-374a miR-374ab MIMAT0004342 miRNA ATG12 autophagy down Bos taurus prediction 9913 767903 - BGD:BT29631|Ensembl:ENSBTAG00000017525 10 - ATG12 autophagy related 12 homolog (S. cerevisiae) protein-coding - bta-miR-374a predicted by miR-374a (Homo sapiens), and ATG12 predicted by ATG12 (Homo sapiens) according to Pubmed ID (22356768) 4121 bta-miR-16a miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0009242 miRNA ATG5 autophagy down Bos taurus prediction 9913 532686 - BGD:BT28451|Ensembl:ENSBTAG00000005400 9 - ATG5 autophagy related 5 homolog (S. cerevisiae) protein-coding - bta-miR-16a predicted by miR-16 (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (23143396) 4122 bta-let-7a let-7/98/4458/4500 MIMAT0003844 miRNA IGF1R autophagy down Bos taurus prediction 9913 281848 IGFR1 BGD:BT29334|Ensembl:ENSBTAG00000021527 21 - insulin-like growth factor 1 receptor protein-coding - bta-let-7a predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 4123 bta-miR-301a miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0009276 miRNA ATG2B autophagy down Bos taurus prediction 9913 519961 - Ensembl:ENSBTAG00000012833 21 - autophagy related 2B protein-coding - bta-miR-301a predicted by miR-130a (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (22902544) 4124 bta-miR-16a miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0009242 miRNA BAG5 autophagy down Bos taurus prediction 9913 522854 - BGD:BT25018|Ensembl:ENSBTAG00000017361 21 - BCL2-associated athanogene 5 protein-coding - bta-miR-16a predicted by miR-16 (Mus musculus), and BAG5 predicted by Bag5 (Mus musculus) according to Pubmed ID (21770019) 4125 bta-miR-155 miR-155 MIMAT0009241 miRNA ATG3 autophagy down Bos taurus prediction 9913 508571 - BGD:BT13656|Ensembl:ENSBTAG00000009084 1 - ATG3 autophagy related 3 homolog (S. cerevisiae) protein-coding - bta-miR-155 predicted by miR-155 (Homo sapiens), and ATG3 predicted by ATG3 (Homo sapiens) according to Pubmed ID (22135297) 4126 bta-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0009218 miRNA ATG7 autophagy down Bos taurus prediction 9913 787967 - Ensembl:ENSBTAG00000035827 22 - autophagy related 7 protein-coding - bta-miR-106b predicted by miR-17 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 4127 bta-miR-92b miR-25/32/92abc/363/363-3p/367 MIMAT0009384 miRNA UVRAG autophagy down Bos taurus prediction 9913 614285 - BGD:BT19521|Ensembl:ENSBTAG00000016355 15 - UV radiation resistance associated gene protein-coding - bta-miR-92b predicted by miR-32 (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22135297) 4128 bta-miR-15b miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0003792 miRNA ATG5 autophagy down Bos taurus prediction 9913 532686 - BGD:BT28451|Ensembl:ENSBTAG00000005400 9 - ATG5 autophagy related 5 homolog (S. cerevisiae) protein-coding - bta-miR-15b predicted by miR-16 (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (23143396) 4129 bta-miR-93 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003837 miRNA ATG5 autophagy down Bos taurus prediction 9913 532686 - BGD:BT28451|Ensembl:ENSBTAG00000005400 9 - ATG5 autophagy related 5 homolog (S. cerevisiae) protein-coding - bta-miR-93 predicted by miR-20a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (25485521) 4130 bta-miR-106 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003784 miRNA ATG5 autophagy down Bos taurus prediction 9913 532686 - BGD:BT28451|Ensembl:ENSBTAG00000005400 9 - ATG5 autophagy related 5 homolog (S. cerevisiae) protein-coding - bta-miR-106 predicted by miR-20a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (25485521) 4131 bta-miR-30c miR-30abcdef/30abe-5p/384-5p MIMAT0003850 miRNA ATG5 autophagy down Bos taurus prediction 9913 532686 - BGD:BT28451|Ensembl:ENSBTAG00000005400 9 - ATG5 autophagy related 5 homolog (S. cerevisiae) protein-coding - bta-miR-30c predicted by miR-30a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22395361),(22617440),(22902544),(23274497),(24148619) 4132 bta-miR-99b miR-99ab/100 MIMAT0004345 miRNA MTOR autophagy down Bos taurus prediction 9913 100139219 - BGD:BT29876|Ensembl:ENSBTAG00000015325 16 - mechanistic target of rapamycin (serine/threonine kinase) protein-coding - bta-miR-99b predicted by miR-100 (Homo sapiens), and MTOR predicted by MTOR (Homo sapiens) according to Pubmed ID (25026290) 4133 bta-miR-96 miR-96/507/1271 MIMAT0009388 miRNA MTOR autophagy down Bos taurus prediction 9913 100139219 - BGD:BT29876|Ensembl:ENSBTAG00000015325 16 - mechanistic target of rapamycin (serine/threonine kinase) protein-coding - bta-miR-96 predicted by miR-96 (Homo sapiens), and MTOR predicted by MTOR (Homo sapiens) according to Pubmed ID (25333253) 4134 bta-miR-143 miR-143/1721/4770 MIMAT0009233 miRNA ATG2B autophagy down Bos taurus prediction 9913 519961 - Ensembl:ENSBTAG00000012833 21 - autophagy related 2B protein-coding - bta-miR-143 predicted by miR-143 (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (25322940) 4135 bta-miR-211 miR-204/204b/211 MIMAT0009263 miRNA CAV1 autophagy down Bos taurus prediction 9913 281040 - BGD:BT10178|Ensembl:ENSBTAG00000017869 4 - caveolin 1, caveolae protein, 22kDa protein-coding - bta-miR-211 predicted by miR-204 (Homo sapiens), and CAV1 predicted by CAV1 (Homo sapiens) according to Pubmed ID (25517751) 4136 bta-let-7d let-7/98/4458/4500 MIMAT0003810 miRNA MTOR autophagy down Bos taurus prediction 9913 100139219 - BGD:BT29876|Ensembl:ENSBTAG00000015325 16 - mechanistic target of rapamycin (serine/threonine kinase) protein-coding - bta-let-7d predicted by let-7 (Homo sapiens), and MTOR predicted by MTOR (Homo sapiens) according to Pubmed ID (25295787) 4137 bta-miR-17-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003815 miRNA FYCO1 autophagy down Bos taurus prediction 9913 100139246 - BGD:BT30103|Ensembl:ENSBTAG00000015698 22 - FYVE and coiled-coil domain containing 1 protein-coding - bta-miR-17-5p predicted by miR-93 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 4138 bta-miR-454 miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0009326 miRNA ATG2B autophagy down Bos taurus prediction 9913 519961 - Ensembl:ENSBTAG00000012833 21 - autophagy related 2B protein-coding - bta-miR-454 predicted by miR-130a (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (22902544) 4139 bta-miR-29c miR-29abcd MIMAT0003829 miRNA PSME4 autophagy down Bos taurus prediction 9913 528142 - BGD:BT15703|Ensembl:ENSBTAG00000020262 11 - proteasome (prosome, macropain) activator subunit 4 protein-coding - bta-miR-29c predicted by miR-29b (Homo sapiens), and PSME4 predicted by PSME4 (Homo sapiens) according to Pubmed ID (25234165) 4140 bta-miR-15b miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0003792 miRNA ATG14 autophagy down Bos taurus prediction 9913 538831 - BGD:BT20206|Ensembl:ENSBTAG00000010795 10 - ATG14 autophagy related 14 homolog (S. cerevisiae) protein-coding - bta-miR-15b predicted by miR-195 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 4141 bta-miR-16a miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0009242 miRNA ATG14 autophagy down Bos taurus prediction 9913 538831 - BGD:BT20206|Ensembl:ENSBTAG00000010795 10 - ATG14 autophagy related 14 homolog (S. cerevisiae) protein-coding - bta-miR-16a predicted by miR-195 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 4142 bta-miR-30d miR-30abcdef/30abe-5p/384-5p MIMAT0003533 miRNA ATG12 autophagy down Bos taurus prediction 9913 767903 - BGD:BT29631|Ensembl:ENSBTAG00000017525 10 - ATG12 autophagy related 12 homolog (S. cerevisiae) protein-coding - bta-miR-30d predicted by miR-30b (Homo sapiens), and ATG12 predicted by ATG12 (Homo sapiens) according to Pubmed ID (22647547),(23274497) 4143 bta-let-7i let-7/98/4458/4500 MIMAT0003851 miRNA IGF1R autophagy down Bos taurus prediction 9913 281848 IGFR1 BGD:BT29334|Ensembl:ENSBTAG00000021527 21 - insulin-like growth factor 1 receptor protein-coding - bta-let-7i predicted by let-7i (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 4144 bta-miR-17-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003815 miRNA ATG5 autophagy down Bos taurus prediction 9913 532686 - BGD:BT28451|Ensembl:ENSBTAG00000005400 9 - ATG5 autophagy related 5 homolog (S. cerevisiae) protein-coding - bta-miR-17-5p predicted by miR-20a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (25485521) 4145 bta-miR-16b miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0003525 miRNA ATG14 autophagy down Bos taurus prediction 9913 538831 - BGD:BT20206|Ensembl:ENSBTAG00000010795 10 - ATG14 autophagy related 14 homolog (S. cerevisiae) protein-coding - bta-miR-16b predicted by miR-195 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 4146 bta-miR-21 miR-21/590-5p MIMAT0003528 miRNA PIK3C3 autophagy down Bos taurus prediction 9913 534815 - Ensembl:ENSBTAG00000026290 24 - phosphatidylinositol 3-kinase, catalytic subunit type 3 protein-coding - bta-miR-21 predicted by miR-21 (Homo sapiens), and PIK3C3 predicted by PIK3C3 (Homo sapiens) according to Pubmed ID (23834154) 4147 bta-miR-17-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003815 miRNA BECN1 autophagy down Bos taurus prediction 9913 527278 ATG6 BGD:BT26123|Ensembl:ENSBTAG00000019914 19 - beclin 1, autophagy related protein-coding - bta-miR-17-5p predicted by miR-17-5p (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (24755562),(25435430),(25485521) 4148 bta-miR-124b miR-124/124ab/506 MIMAT0013774 miRNA ANTXR2 autophagy down Bos taurus prediction 9913 510080 - BGD:BT22571|Ensembl:ENSBTAG00000014324 6 - anthrax toxin receptor 2 protein-coding - bta-miR-124b predicted by miR-124 (Homo sapiens), and ANTXR2 predicted by ANTXR2 (Homo sapiens) according to Pubmed ID (25736362) 4149 bta-miR-17-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003815 miRNA ATG7 autophagy down Bos taurus prediction 9913 787967 - Ensembl:ENSBTAG00000035827 22 - autophagy related 7 protein-coding - bta-miR-17-5p predicted by miR-17 (Homo sapiens), and ATG7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 4150 bta-miR-130b miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0009224 miRNA ATG2B autophagy down Bos taurus prediction 9913 519961 - Ensembl:ENSBTAG00000012833 21 - autophagy related 2B protein-coding - bta-miR-130b predicted by miR-130a (Homo sapiens), and ATG2B predicted by ATG2B (Homo sapiens) according to Pubmed ID (22902544) 4151 bta-let-7g let-7/98/4458/4500 MIMAT0003838 miRNA MTOR autophagy down Bos taurus prediction 9913 100139219 - BGD:BT29876|Ensembl:ENSBTAG00000015325 16 - mechanistic target of rapamycin (serine/threonine kinase) protein-coding - bta-let-7g predicted by let-7 (Homo sapiens), and MTOR predicted by MTOR (Homo sapiens) according to Pubmed ID (25295787) 4152 bta-miR-199b miR-199ab-5p MIMAT0003821 miRNA BECN1 autophagy down Bos taurus prediction 9913 527278 ATG6 BGD:BT26123|Ensembl:ENSBTAG00000019914 19 - beclin 1, autophagy related protein-coding - bta-miR-199b predicted by miR-199a-5p (Homo sapiens), and BECN1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (23337876) 4153 bta-miR-200c miR-200bc/429/548a MIMAT0003823 miRNA UBQLN1 autophagy down Bos taurus prediction 9913 282392 - Ensembl:ENSBTAG00000014827 8 - ubiquilin 1 protein-coding - bta-miR-200c predicted by miR-200c (Homo sapiens), and UBQLN1 predicted by UBQLN1 (Homo sapiens) according to Pubmed ID (25044403) 4154 bta-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0009218 miRNA ATG5 autophagy down Bos taurus prediction 9913 532686 - BGD:BT28451|Ensembl:ENSBTAG00000005400 9 - ATG5 autophagy related 5 homolog (S. cerevisiae) protein-coding - bta-miR-106b predicted by miR-20a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (25485521) 4155 bta-miR-302c miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0009281 miRNA ATG7 autophagy down Bos taurus prediction 9913 787967 - Ensembl:ENSBTAG00000035827 22 - autophagy related 7 protein-coding - bta-miR-302c predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 4156 bta-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0009218 miRNA SQSTM1 autophagy down Bos taurus prediction 9913 338045 - BGD:BT16900|Ensembl:ENSBTAG00000015591 7 - sequestosome 1 protein-coding - bta-miR-106b predicted by miR-106b (Homo sapiens),miR-106 (Mus musculus), and SQSTM1 predicted by Sqstm1 (Mus musculus),SQSTM1 (Homo sapiens) according to Pubmed ID (21628417),(22441107),(25485521),(25617127) 4157 bta-miR-424 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0013593 miRNA ATG5 autophagy down Bos taurus prediction 9913 532686 - BGD:BT28451|Ensembl:ENSBTAG00000005400 9 - ATG5 autophagy related 5 homolog (S. cerevisiae) protein-coding - bta-miR-424 predicted by miR-16 (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (23143396) 4158 bta-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0009218 miRNA FYCO1 autophagy down Bos taurus prediction 9913 100139246 - BGD:BT30103|Ensembl:ENSBTAG00000015698 22 - FYVE and coiled-coil domain containing 1 protein-coding - bta-miR-106b predicted by miR-93 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 4159 bta-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003527 miRNA ATG5 autophagy down Bos taurus prediction 9913 532686 - BGD:BT28451|Ensembl:ENSBTAG00000005400 9 - ATG5 autophagy related 5 homolog (S. cerevisiae) protein-coding - bta-miR-20a predicted by miR-20a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (25485521) 4160 bta-miR-374b miR-374ab MIMAT0009302 miRNA UVRAG autophagy down Bos taurus prediction 9913 614285 - BGD:BT19521|Ensembl:ENSBTAG00000016355 15 - UV radiation resistance associated gene protein-coding - bta-miR-374b predicted by miR-374a (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22356768) 4161 bta-miR-25 miR-25/32/92abc/363/363-3p/367 MIMAT0003853 miRNA UVRAG autophagy down Bos taurus prediction 9913 614285 - BGD:BT19521|Ensembl:ENSBTAG00000016355 15 - UV radiation resistance associated gene protein-coding - bta-miR-25 predicted by miR-32 (Homo sapiens), and UVRAG predicted by UVRAG (Homo sapiens) according to Pubmed ID (22135297) 4162 bta-miR-320 miR-320abcd/4429 MIMAT0003534 miRNA ULK1 autophagy down Bos taurus prediction 9913 526310 - BGD:BT26556|Ensembl:ENSBTAG00000012987 17 - unc-51-like kinase 1 (C. elegans) protein-coding - bta-miR-320 predicted by miR-320a (Homo sapiens), and ULK1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (23622248) 4163 bta-miR-449c miR-34ac/34bc-5p/449abc/449c-5p MIMAT0009322 miRNA ATG4B autophagy down Bos taurus prediction 9913 408002 Aut2b2 Ensembl:ENSBTAG00000015401 3 - autophagy related 4B, cysteine peptidase protein-coding - bta-miR-449c predicted by miR-34a (Homo sapiens), and ATG4B predicted by ATG4B (Homo sapiens) according to Pubmed ID (24755409) 4164 bta-miR-30a-5p miR-30abcdef/30abe-5p/384-5p MIMAT0003841 miRNA ATG12 autophagy down Bos taurus prediction 9913 767903 - BGD:BT29631|Ensembl:ENSBTAG00000017525 10 - ATG12 autophagy related 12 homolog (S. cerevisiae) protein-coding - bta-miR-30a-5p predicted by miR-30b (Homo sapiens), and ATG12 predicted by ATG12 (Homo sapiens) according to Pubmed ID (22647547),(23274497) 4165 bta-miR-195 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0004335 miRNA BAG5 autophagy down Bos taurus prediction 9913 522854 - BGD:BT25018|Ensembl:ENSBTAG00000017361 21 - BCL2-associated athanogene 5 protein-coding - bta-miR-195 predicted by miR-16 (Mus musculus), and BAG5 predicted by Bag5 (Mus musculus) according to Pubmed ID (21770019) 4166 bta-miR-181c miR-181abcd/4262 MIMAT0003817 miRNA TP63 autophagy down Bos taurus prediction 9913 615335 - BGD:BT10014|Ensembl:ENSBTAG00000015460 1 - tumor protein p63 protein-coding - bta-miR-181c predicted by miR-181a (Homo sapiens), and TP63 predicted by TP63 (Homo sapiens) according to Pubmed ID (22356768) 4167 bta-miR-302b miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0009280 miRNA ATG7 autophagy down Bos taurus prediction 9913 787967 - Ensembl:ENSBTAG00000035827 22 - autophagy related 7 protein-coding - bta-miR-302b predicted by miR-291 (Mus musculus), and ATG7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 4168 bta-miR-224 miR-224 MIMAT0009271 miRNA SMAD4 autophagy down Bos taurus prediction 9913 540248 - BGD:BT11762|Ensembl:ENSBTAG00000006919 24 - SMAD family member 4 protein-coding - bta-miR-224 predicted by miR-224 (Homo sapiens), and SMAD4 predicted by SMAD4 (Homo sapiens) according to Pubmed ID (23913306),(25068270) 4169 bta-miR-449c miR-34ac/34bc-5p/449abc/449c-5p MIMAT0009322 miRNA ATG9A autophagy down Bos taurus prediction 9913 540482 ATG9 BGD:BT13106|Ensembl:ENSBTAG00000020608 2 - ATG9 autophagy related 9 homolog A (S. cerevisiae) protein-coding - bta-miR-449c predicted by miR-34a (Homo sapiens),miR-34a (Rattus norvegicus), and ATG9A predicted by Atg9a (Rattus norvegicus),ATG9A (Homo sapiens) according to Pubmed ID (22902544),(24728149),(24973144) 4170 bta-miR-30c miR-30abcdef/30abe-5p/384-5p MIMAT0003850 miRNA BNIP3L autophagy down Bos taurus prediction 9913 534615 - BGD:BT17341|Ensembl:ENSBTAG00000021307 8 - BCL2/adenovirus E1B 19kDa interacting protein 3-like protein-coding - bta-miR-30c predicted by miR-30d (Homo sapiens), and BNIP3L predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 4171 bta-miR-124a miR-124/124ab/506 MIMAT0003811 miRNA ANTXR2 autophagy down Bos taurus prediction 9913 510080 - BGD:BT22571|Ensembl:ENSBTAG00000014324 6 - anthrax toxin receptor 2 protein-coding - bta-miR-124a predicted by miR-124 (Homo sapiens), and ANTXR2 predicted by ANTXR2 (Homo sapiens) according to Pubmed ID (25736362) 4172 bta-miR-99a miR-99ab/100 MIMAT0003537 miRNA IGF1R autophagy down Bos taurus prediction 9913 281848 IGFR1 BGD:BT29334|Ensembl:ENSBTAG00000021527 21 - insulin-like growth factor 1 receptor protein-coding - bta-miR-99a predicted by miR-100 (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25026290) 4173 bta-miR-106 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003784 miRNA FYCO1 autophagy down Bos taurus prediction 9913 100139246 - BGD:BT30103|Ensembl:ENSBTAG00000015698 22 - FYVE and coiled-coil domain containing 1 protein-coding - bta-miR-106 predicted by miR-93 (Homo sapiens), and FYCO1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 4174 bta-miR-424 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0013593 miRNA ATG14 autophagy down Bos taurus prediction 9913 538831 - BGD:BT20206|Ensembl:ENSBTAG00000010795 10 - ATG14 autophagy related 14 homolog (S. cerevisiae) protein-coding - bta-miR-424 predicted by miR-195 (Homo sapiens), and ATG14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 4175 bta-miR-99a miR-99ab/100 MIMAT0003537 miRNA MTOR autophagy down Bos taurus prediction 9913 100139219 - BGD:BT29876|Ensembl:ENSBTAG00000015325 16 - mechanistic target of rapamycin (serine/threonine kinase) protein-coding - bta-miR-99a predicted by miR-100 (Homo sapiens), and MTOR predicted by MTOR (Homo sapiens) according to Pubmed ID (25026290) 4176 bta-miR-99b miR-99ab/100 MIMAT0004345 miRNA IGF1R autophagy down Bos taurus prediction 9913 281848 IGFR1 BGD:BT29334|Ensembl:ENSBTAG00000021527 21 - insulin-like growth factor 1 receptor protein-coding - bta-miR-99b predicted by miR-100 (Homo sapiens), and IGF1R predicted by IGF1R (Homo sapiens) according to Pubmed ID (25026290) 4177 bta-miR-181a miR-181abcd/4262 MIMAT0003543 miRNA ATG5 autophagy down Bos taurus prediction 9913 532686 - BGD:BT28451|Ensembl:ENSBTAG00000005400 9 - ATG5 autophagy related 5 homolog (S. cerevisiae) protein-coding - bta-miR-181a predicted by miR-181a (Homo sapiens), and ATG5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22356768),(22902544),(23322078) 4178 bta-miR-30c miR-30abcdef/30abe-5p/384-5p MIMAT0003850 miRNA ATG12 autophagy down Bos taurus prediction 9913 767903 - BGD:BT29631|Ensembl:ENSBTAG00000017525 10 - ATG12 autophagy related 12 homolog (S. cerevisiae) protein-coding - bta-miR-30c predicted by miR-30b (Homo sapiens), and ATG12 predicted by ATG12 (Homo sapiens) according to Pubmed ID (22647547),(23274497) 4179 mmu-miR-101a miR-101/101ab MIMAT0000133 miRNA Stmn1 autophagy down Mus musculus prediction 10090 16765 19k|Lag|Lap18|Op18|P18|P19|Pig|Pp17|Pp18|Pp19|Pr22|Smn MGI:96739|Ensembl:ENSMUSG00000028832|Vega:OTTMUSG00000010830 4 4 D3|4 66.76 cM stathmin 1 protein-coding stathmin 1 mmu-miR-101a predicted by miR-101 (Homo sapiens), and Stmn1 predicted by STMN1 (Homo sapiens) according to Pubmed ID (21915098),(23483142),(25607713) 4180 mmu-miR-211 miR-204/204b/211 MIMAT0000668 miRNA Vhl autophagy down Mus musculus prediction 10090 22346 Vhlh MGI:103223|Ensembl:ENSMUSG00000033933|Vega:OTTMUSG00000024147 6 6 E3|6 52.81 cM von Hippel-Lindau tumor suppressor protein-coding von Hippel-Lindau tumor suppressor mmu-miR-211 predicted by miR-204 (Homo sapiens), and Vhl predicted by VHL (Homo sapiens) according to Pubmed ID (25517751) 4181 mmu-miR-18a miR-18ab/4735-3p MIMAT0000528 miRNA Atm autophagy down Mus musculus prediction 10090 11920 AI256621|C030026E19Rik MGI:107202|Ensembl:ENSMUSG00000034218|Vega:OTTMUSG00000031707 9 9 C-D|9 29.12 cM ataxia telangiectasia mutated protein-coding ataxia telangiectasia mutated mmu-miR-18a predicted by miR-18a (Homo sapiens), and Atm predicted by ATM (Homo sapiens) according to Pubmed ID (23229340) 4182 mmu-miR-200b miR-200bc/429/548a MIMAT0000233 miRNA Ubqln1 autophagy down Mus musculus prediction 10090 56085 1110046H03Rik|1810030E05Rik|AU019746|C77538|D13Ertd372e|Da41|Dsk2|Plic-1|Plic1|Xdrp1 MGI:1860276|Ensembl:ENSMUSG00000005312 13 13 B1|13 30.95 cM ubiquilin 1 protein-coding ubiquilin 1 mmu-miR-200b predicted by miR-200c (Homo sapiens), and Ubqln1 predicted by UBQLN1 (Homo sapiens) according to Pubmed ID (25044403) 4183 mmu-miR-192 miR-192/215 MIMAT0000517 miRNA Atg4a autophagy down Mus musculus prediction 10090 666468 AI627006|AV169859|Apg4a|Atg4al|Autl2 MGI:2147903|Ensembl:ENSMUSG00000079418|Vega:OTTMUSG00000018921 X X F1|X autophagy related 4A, cysteine peptidase protein-coding autophagy related 4A, cysteine peptidase mmu-miR-192 predicted by miR-192 (Homo sapiens), and Atg4a predicted by ATG4A (Homo sapiens) according to Pubmed ID (19074876) 4184 mmu-let-7e let-7/98/4458/4500 MIMAT0000524 miRNA Olr1 autophagy down Mus musculus prediction 10090 108078 LOX-1|SR-EI|Scare1 MGI:1261434|Ensembl:ENSMUSG00000030162|Vega:OTTMUSG00000034583 6 6 F3|6 oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding oxidized low density lipoprotein (lectin-like) receptor 1 mmu-let-7e predicted by let-7g (Mus musculus), and Olr1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 4185 mmu-miR-30d miR-30abcdef/30abe-5p/384-5p MIMAT0000515 miRNA Becn1 autophagy down Mus musculus prediction 10090 56208 4921513J16Rik|5430417M23Rik|Atg6 MGI:1891828 11 11 D|11 beclin 1, autophagy related protein-coding beclin 1, autophagy related mmu-miR-30d predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and Becn1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 4186 mmu-miR-31 miR-31 MIMAT0000538 miRNA Gsk3b autophagy down Mus musculus prediction 10090 56637 7330414F15Rik|8430431H08Rik|C86142|GSK-3|GSK-3beta|GSK3 MGI:1861437|Ensembl:ENSMUSG00000022812|Vega:OTTMUSG00000016276 16 16|16 B4 glycogen synthase kinase 3 beta protein-coding glycogen synthase kinase 3 beta mmu-miR-31 predicted by miR-31 (Homo sapiens), and Gsk3b predicted by GSK3B (Homo sapiens) according to Pubmed ID (24343269) 4187 mmu-miR-195 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000225 miRNA Atg14 autophagy down Mus musculus prediction 10090 100504663 4832427M01|Atg14L|D14Ertd114e|D14Ertd436e MGI:1261775|Ensembl:ENSMUSG00000037526 14 14 C1|14 24.6 cM autophagy related 14 protein-coding autophagy related 14 mmu-miR-195 predicted by miR-195 (Homo sapiens), and Atg14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 4188 mmu-miR-294 miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0000372 miRNA Atg7 autophagy down Mus musculus prediction 10090 74244 1810013K23Rik|Agp7|Apg7l|Atg7l|Gm21553 MGI:1921494|Ensembl:ENSMUSG00000030314|Vega:OTTMUSG00000043567 6 6 E3|6 autophagy related 7 protein-coding autophagy related 7 mmu-miR-294 predicted by miR-291 (Mus musculus), and Atg7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 4189 mmu-miR-106a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000385 miRNA Atg7 autophagy down Mus musculus prediction 10090 74244 1810013K23Rik|Agp7|Apg7l|Atg7l|Gm21553 MGI:1921494|Ensembl:ENSMUSG00000030314|Vega:OTTMUSG00000043567 6 6 E3|6 autophagy related 7 protein-coding autophagy related 7 mmu-miR-106a predicted by miR-17 (Homo sapiens), and Atg7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 4190 mmu-miR-124 miR-124/124ab/506 MIMAT0000134 miRNA Antxr2 autophagy down Mus musculus prediction 10090 71914 2310046B19Rik|AW561899|CMG-2|CMG2|cI-35 MGI:1919164 5 5 E3|5 anthrax toxin receptor 2 protein-coding anthrax toxin receptor 2 mmu-miR-124 predicted by miR-124 (Homo sapiens), and Antxr2 predicted by ANTXR2 (Homo sapiens) according to Pubmed ID (25736362) 4191 mmu-miR-497 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0003453 miRNA Bcl2l2 autophagy down Mus musculus prediction 10090 12050 AW048834|Bcl-w|Gtrgal2|Gtrosa41|bclw|c98 MGI:108052|Ensembl:ENSMUSG00000089682|Vega:OTTMUSG00000032812 14 14 C3|14 27.98 cM BCL2-like 2 protein-coding BCL2-like 2 mmu-miR-497 predicted by miR-15b (Mus musculus), and Bcl2l2 predicted by Bcl2l2 (Mus musculus) according to Pubmed ID (21770019) 4192 mmu-miR-200c miR-200bc/429/548a MIMAT0000657 miRNA Ubqln1 autophagy down Mus musculus prediction 10090 56085 1110046H03Rik|1810030E05Rik|AU019746|C77538|D13Ertd372e|Da41|Dsk2|Plic-1|Plic1|Xdrp1 MGI:1860276|Ensembl:ENSMUSG00000005312 13 13 B1|13 30.95 cM ubiquilin 1 protein-coding ubiquilin 1 mmu-miR-200c predicted by miR-200c (Homo sapiens), and Ubqln1 predicted by UBQLN1 (Homo sapiens) according to Pubmed ID (25044403) 4193 mmu-miR-148a miR-148ab-3p/152 MIMAT0000516 miRNA Atg14 autophagy down Mus musculus prediction 10090 100504663 4832427M01|Atg14L|D14Ertd114e|D14Ertd436e MGI:1261775|Ensembl:ENSMUSG00000037526 14 14 C1|14 24.6 cM autophagy related 14 protein-coding autophagy related 14 mmu-miR-148a predicted by miR-152 (Homo sapiens), and Atg14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (25650716) 4194 mmu-miR-93 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000540 miRNA Hif1a autophagy down Mus musculus prediction 10090 15251 AA959795|HIF1alpha|MOP1|bHLHe78 MGI:106918|Ensembl:ENSMUSG00000021109|Vega:OTTMUSG00000019740 12 12 C3|12 31.99 cM hypoxia inducible factor 1, alpha subunit protein-coding hypoxia inducible factor 1, alpha subunit mmu-miR-93 predicted by miR-20a (Homo sapiens), and Hif1a predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 4195 mmu-miR-291a-3p miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0000368 miRNA Ulk1 autophagy down Mus musculus prediction 10090 22241 AU041434|Unc51.1|mKIAA0722 MGI:1270126|Ensembl:ENSMUSG00000029512 5 5|5 F unc-51 like kinase 1 protein-coding unc-51 like kinase 1 mmu-miR-291a-3p predicted by miR-291 (Mus musculus), and Ulk1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 4196 mmu-miR-210 miR-210 MIMAT0000658 miRNA Bcl2 autophagy down Mus musculus prediction 10090 12043 AW986256|Bcl-2|C430015F12Rik|D630044D05Rik|D830018M01Rik MGI:88138|Ensembl:ENSMUSG00000057329|Vega:OTTMUSG00000022128 1 1 E2.1|1 49.76 cM B cell leukemia/lymphoma 2 protein-coding B cell leukemia/lymphoma 2 mmu-miR-210 predicted by miR-210 (Homo sapiens), and Bcl2 predicted by BCL2 (Homo sapiens) according to Pubmed ID (25385144) 4197 mmu-let-7i let-7/98/4458/4500 MIMAT0000122 miRNA Olr1 autophagy down Mus musculus prediction 10090 108078 LOX-1|SR-EI|Scare1 MGI:1261434|Ensembl:ENSMUSG00000030162|Vega:OTTMUSG00000034583 6 6 F3|6 oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding oxidized low density lipoprotein (lectin-like) receptor 1 mmu-let-7i predicted by let-7g (Mus musculus), and Olr1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 4198 mmu-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003187 miRNA Ulk1 autophagy down Mus musculus prediction 10090 22241 AU041434|Unc51.1|mKIAA0722 MGI:1270126|Ensembl:ENSMUSG00000029512 5 5|5 F unc-51 like kinase 1 protein-coding unc-51 like kinase 1 mmu-miR-20b predicted by miR-106b (Homo sapiens), and Ulk1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 4199 mmu-miR-155 miR-155 MIMAT0000165 miRNA Rheb autophagy down Mus musculus prediction 10090 19744 - MGI:97912|Ensembl:ENSMUSG00000028945|Vega:OTTMUSG00000023527 5 5 A3|5 Ras homolog enriched in brain protein-coding Ras homolog enriched in brain mmu-miR-155 predicted by miR-155 (Homo sapiens), and Rheb predicted by RHEB (Homo sapiens) according to Pubmed ID (24130493),(24262949) 4200 mmu-miR-93 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000540 miRNA Atg7 autophagy down Mus musculus prediction 10090 74244 1810013K23Rik|Agp7|Apg7l|Atg7l|Gm21553 MGI:1921494|Ensembl:ENSMUSG00000030314|Vega:OTTMUSG00000043567 6 6 E3|6 autophagy related 7 protein-coding autophagy related 7 mmu-miR-93 predicted by miR-17 (Homo sapiens), and Atg7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 4201 mmu-miR-101b miR-101/101ab MIMAT0000616 miRNA Stmn1 autophagy down Mus musculus prediction 10090 16765 19k|Lag|Lap18|Op18|P18|P19|Pig|Pp17|Pp18|Pp19|Pr22|Smn MGI:96739|Ensembl:ENSMUSG00000028832|Vega:OTTMUSG00000010830 4 4 D3|4 66.76 cM stathmin 1 protein-coding stathmin 1 mmu-miR-101b predicted by miR-101 (Homo sapiens), and Stmn1 predicted by STMN1 (Homo sapiens) according to Pubmed ID (21915098),(23483142),(25607713) 4202 mmu-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000386 miRNA Ulk1 autophagy down Mus musculus prediction 10090 22241 AU041434|Unc51.1|mKIAA0722 MGI:1270126|Ensembl:ENSMUSG00000029512 5 5|5 F unc-51 like kinase 1 protein-coding unc-51 like kinase 1 mmu-miR-106b predicted by miR-106b (Homo sapiens), and Ulk1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 4203 mmu-miR-205 miR-205/205ab MIMAT0000238 miRNA Lamp3 autophagy down Mus musculus prediction 10090 239739 1200002D17Rik|Cd208|DC-LAMP|DCLAMP|LAMP|TSC403 MGI:2441659|Ensembl:ENSMUSG00000041247 16 16 A3|16 lysosomal-associated membrane protein 3 protein-coding lysosomal-associated membrane protein 3 mmu-miR-205 predicted by miR-205 (Homo sapiens), and Lamp3 predicted by LAMP3 (Homo sapiens) according to Pubmed ID (24370341) 4204 mmu-miR-137 miR-137/137ab MIMAT0000149 miRNA Bnip3l autophagy down Mus musculus prediction 10090 12177 C86132|D14Ertd719e|Nip3L|Nix MGI:1332659|Ensembl:ENSMUSG00000022051|Vega:OTTMUSG00000023686 14 14 D1|14 34.6 cM BCL2/adenovirus E1B interacting protein 3-like protein-coding BCL2/adenovirus E1B interacting protein 3-like mmu-miR-137 predicted by miR-137 (Homo sapiens), and Bnip3l predicted by BNIP3L (Homo sapiens) according to Pubmed ID (24573672) 4205 mmu-miR-30d miR-30abcdef/30abe-5p/384-5p MIMAT0000515 miRNA Bnip3l autophagy down Mus musculus prediction 10090 12177 C86132|D14Ertd719e|Nip3L|Nix MGI:1332659|Ensembl:ENSMUSG00000022051|Vega:OTTMUSG00000023686 14 14 D1|14 34.6 cM BCL2/adenovirus E1B interacting protein 3-like protein-coding BCL2/adenovirus E1B interacting protein 3-like mmu-miR-30d predicted by miR-30d (Homo sapiens), and Bnip3l predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 4206 mmu-miR-367 miR-25/32/92abc/363/363-3p/367 MIMAT0003181 miRNA Ulk1 autophagy down Mus musculus prediction 10090 22241 AU041434|Unc51.1|mKIAA0722 MGI:1270126|Ensembl:ENSMUSG00000029512 5 5|5 F unc-51 like kinase 1 protein-coding unc-51 like kinase 1 mmu-miR-367 predicted by miR-25 (Homo sapiens), and Ulk1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (25026296) 4207 mmu-miR-204 miR-204/204b/211 MIMAT0000237 miRNA Cav1 autophagy down Mus musculus prediction 10090 12389 Cav|Cav-1 MGI:102709|Ensembl:ENSMUSG00000007655|Vega:OTTMUSG00000024023 6 6|6 A2 caveolin 1, caveolae protein protein-coding caveolin 1, caveolae protein mmu-miR-204 predicted by miR-204 (Homo sapiens), and Cav1 predicted by CAV1 (Homo sapiens) according to Pubmed ID (25517751) 4208 mmu-let-7c let-7/98/4458/4500 MIMAT0000523 miRNA Mtor autophagy down Mus musculus prediction 10090 56717 2610315D21Rik|AI327068|FRAP|FRAP2|Frap1|RAFT1|RAPT1|flat MGI:1928394|Ensembl:ENSMUSG00000028991|Vega:OTTMUSG00000010950 4 4 E1|4 78.76 cM mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) mmu-let-7c predicted by let-7 (Homo sapiens), and Mtor predicted by MTOR (Homo sapiens) according to Pubmed ID (25295787) 4209 mmu-miR-384-5p miR-30abcdef/30abe-5p/384-5p MIMAT0004745 miRNA Atg12 autophagy down Mus musculus prediction 10090 67526 4931423H11Rik|A330058M13Rik|Apg12l|Atg12l MGI:1914776|Ensembl:ENSMUSG00000032905 18 18 C|18 autophagy related 12 protein-coding autophagy related 12 mmu-miR-384-5p predicted by miR-30b (Homo sapiens), and Atg12 predicted by ATG12 (Homo sapiens) according to Pubmed ID (22647547),(23274497) 4210 mmu-miR-449b miR-34ac/34bc-5p/449abc/449c-5p MIMAT0005447 miRNA Atg9a autophagy down Mus musculus prediction 10090 245860 AU019532|Apg9l1|Atg9|Atg9l1 MGI:2138446|Ensembl:ENSMUSG00000033124 1 1 C3|1 autophagy related 9A protein-coding autophagy related 9A mmu-miR-449b predicted by miR-34a (Homo sapiens),miR-34a (Rattus norvegicus), and Atg9a predicted by Atg9a (Rattus norvegicus),ATG9A (Homo sapiens) according to Pubmed ID (22902544),(24728149),(24973144) 4211 mmu-miR-301a miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0000379 miRNA Rb1cc1 autophagy down Mus musculus prediction 10090 12421 2900055E04Rik|5930404L04Rik|Cc1|FIP200|LaXp180 MGI:1341850|Ensembl:ENSMUSG00000025907|Vega:OTTMUSG00000033467 1 1|1 A2 RB1-inducible coiled-coil 1 protein-coding RB1-inducible coiled-coil 1 mmu-miR-301a predicted by miR-133b (Homo sapiens), and Rb1cc1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 4212 mmu-miR-18b miR-18ab/4735-3p MIMAT0004858 miRNA Atm autophagy down Mus musculus prediction 10090 11920 AI256621|C030026E19Rik MGI:107202|Ensembl:ENSMUSG00000034218|Vega:OTTMUSG00000031707 9 9 C-D|9 29.12 cM ataxia telangiectasia mutated protein-coding ataxia telangiectasia mutated mmu-miR-18b predicted by miR-18a (Homo sapiens), and Atm predicted by ATM (Homo sapiens) according to Pubmed ID (23229340) 4213 mmu-miR-30a miR-30abcdef/30abe-5p/384-5p MIMAT0000128 miRNA Atg5 autophagy down Mus musculus prediction 10090 11793 2010107M05Rik|3110067M24Rik|AW319544|Apg5l|Atg5l|C88337|Paddy MGI:1277186|Ensembl:ENSMUSG00000038160 10 10 B2|10 23.24 cM autophagy related 5 protein-coding autophagy related 5 mmu-miR-30a predicted by miR-30a (Homo sapiens), and Atg5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22395361),(22617440),(22902544),(23274497),(24148619) 4214 mmu-miR-449c miR-34ac/34bc-5p/449abc/449c-5p MIMAT0003460 miRNA Atg9a autophagy down Mus musculus prediction 10090 245860 AU019532|Apg9l1|Atg9|Atg9l1 MGI:2138446|Ensembl:ENSMUSG00000033124 1 1 C3|1 autophagy related 9A protein-coding autophagy related 9A mmu-miR-449c predicted by miR-34a (Homo sapiens),miR-34a (Rattus norvegicus), and Atg9a predicted by Atg9a (Rattus norvegicus),ATG9A (Homo sapiens) according to Pubmed ID (22902544),(24728149),(24973144) 4215 mmu-miR-34a miR-34ac/34bc-5p/449abc/449c-5p MIMAT0000542 miRNA Atg4b autophagy down Mus musculus prediction 10090 66615 2510009N07Rik|AW048066|Apg4b|Atg4bl|Autl1 MGI:1913865|Ensembl:ENSMUSG00000026280|Vega:OTTMUSG00000032629 1 1 D|1 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase mmu-miR-34a predicted by miR-34a (Homo sapiens), and Atg4b predicted by ATG4B (Homo sapiens) according to Pubmed ID (24755409) 4216 mmu-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000529 miRNA Fyco1 autophagy down Mus musculus prediction 10090 17281 2810409M01Rik|Mem2|RUFY3|ZFYVE7 MGI:107277|Ensembl:ENSMUSG00000025241|Vega:OTTMUSG00000044623 9 9 F|9 74.52 cM FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 mmu-miR-20a predicted by miR-93 (Homo sapiens), and Fyco1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 4217 mmu-miR-212-3p miR-132/212/212-3p MIMAT0000659 miRNA Foxo3 autophagy down Mus musculus prediction 10090 56484 1110048B16Rik|2010203A17Rik|C76856|FKHRL1|Fkhr2|Foxo3a MGI:1890081|Ensembl:ENSMUSG00000048756|Vega:OTTMUSG00000020929 10 10 B2|10 22.79 cM forkhead box O3 protein-coding forkhead box O3 mmu-miR-212-3p predicted by miR-132 (Mus musculus), and Foxo3 predicted by Foxo3 (Mus musculus) according to Pubmed ID (23011132) 4218 mmu-miR-449c miR-34ac/34bc-5p/449abc/449c-5p MIMAT0003460 miRNA Atg4b autophagy down Mus musculus prediction 10090 66615 2510009N07Rik|AW048066|Apg4b|Atg4bl|Autl1 MGI:1913865|Ensembl:ENSMUSG00000026280|Vega:OTTMUSG00000032629 1 1 D|1 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase mmu-miR-449c predicted by miR-34a (Homo sapiens), and Atg4b predicted by ATG4B (Homo sapiens) according to Pubmed ID (24755409) 4219 mmu-miR-211 miR-204/204b/211 MIMAT0000668 miRNA Trpm3 autophagy down Mus musculus prediction 10090 226025 6330504P12Rik|9330180E14|AU018608|B930001P07Rik|LTRPC3|MLSN2 MGI:2443101|Ensembl:ENSMUSG00000052387 19 19 B|19 transient receptor potential cation channel, subfamily M, member 3 protein-coding transient receptor potential cation channel, subfamily M, member 3 mmu-miR-211 predicted by miR-204 (Homo sapiens), and Trpm3 predicted by TRPM3 (Homo sapiens) according to Pubmed ID (25517751) 4220 mmu-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000529 miRNA Atg7 autophagy down Mus musculus prediction 10090 74244 1810013K23Rik|Agp7|Apg7l|Atg7l|Gm21553 MGI:1921494|Ensembl:ENSMUSG00000030314|Vega:OTTMUSG00000043567 6 6 E3|6 autophagy related 7 protein-coding autophagy related 7 mmu-miR-20a predicted by miR-17 (Homo sapiens), and Atg7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 4221 mmu-let-7b let-7/98/4458/4500 MIMAT0000522 miRNA Atg4b autophagy down Mus musculus prediction 10090 66615 2510009N07Rik|AW048066|Apg4b|Atg4bl|Autl1 MGI:1913865|Ensembl:ENSMUSG00000026280|Vega:OTTMUSG00000032629 1 1 D|1 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase mmu-let-7b predicted by let-7b (Homo sapiens), and Atg4b predicted by ATG4B (Homo sapiens) according to Pubmed ID (22135297) 4222 mmu-miR-17 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000649 miRNA Atg16l1 autophagy down Mus musculus prediction 10090 77040 1500009K01Rik|Apg16l|Atg16l|WDR30 MGI:1924290|Ensembl:ENSMUSG00000026289|Vega:OTTMUSG00000016467 1 1 D|1 autophagy related 16-like 1 (S. cerevisiae) protein-coding autophagy related 16-like 1 (S. cerevisiae) mmu-miR-17 predicted by miR-106b (Homo sapiens), and Atg16l1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 4223 mmu-miR-92a miR-25/32/92abc/363/363-3p/367 MIMAT0000539 miRNA Ulk1 autophagy down Mus musculus prediction 10090 22241 AU041434|Unc51.1|mKIAA0722 MGI:1270126|Ensembl:ENSMUSG00000029512 5 5|5 F unc-51 like kinase 1 protein-coding unc-51 like kinase 1 mmu-miR-92a predicted by miR-25 (Homo sapiens), and Ulk1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (25026296) 4224 mmu-miR-181b miR-181abcd/4262 MIMAT0000673 miRNA Atg5 autophagy down Mus musculus prediction 10090 11793 2010107M05Rik|3110067M24Rik|AW319544|Apg5l|Atg5l|C88337|Paddy MGI:1277186|Ensembl:ENSMUSG00000038160 10 10 B2|10 23.24 cM autophagy related 5 protein-coding autophagy related 5 mmu-miR-181b predicted by miR-181a (Homo sapiens), and Atg5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22356768),(22902544),(23322078) 4225 mmu-miR-30b miR-30abcdef/30abe-5p/384-5p MIMAT0000130 miRNA Atg12 autophagy down Mus musculus prediction 10090 67526 4931423H11Rik|A330058M13Rik|Apg12l|Atg12l MGI:1914776|Ensembl:ENSMUSG00000032905 18 18 C|18 autophagy related 12 protein-coding autophagy related 12 mmu-miR-30b predicted by miR-30b (Homo sapiens), and Atg12 predicted by ATG12 (Homo sapiens) according to Pubmed ID (22647547),(23274497) 4226 mmu-miR-204 miR-204/204b/211 MIMAT0000237 miRNA Trpm3 autophagy down Mus musculus prediction 10090 226025 6330504P12Rik|9330180E14|AU018608|B930001P07Rik|LTRPC3|MLSN2 MGI:2443101|Ensembl:ENSMUSG00000052387 19 19 B|19 transient receptor potential cation channel, subfamily M, member 3 protein-coding transient receptor potential cation channel, subfamily M, member 3 mmu-miR-204 predicted by miR-204 (Homo sapiens), and Trpm3 predicted by TRPM3 (Homo sapiens) according to Pubmed ID (25517751) 4227 mmu-miR-301b miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0004186 miRNA Rb1cc1 autophagy down Mus musculus prediction 10090 12421 2900055E04Rik|5930404L04Rik|Cc1|FIP200|LaXp180 MGI:1341850|Ensembl:ENSMUSG00000025907|Vega:OTTMUSG00000033467 1 1|1 A2 RB1-inducible coiled-coil 1 protein-coding RB1-inducible coiled-coil 1 mmu-miR-301b predicted by miR-133b (Homo sapiens), and Rb1cc1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 4228 mmu-miR-30a miR-30abcdef/30abe-5p/384-5p MIMAT0000128 miRNA Becn1 autophagy down Mus musculus prediction 10090 56208 4921513J16Rik|5430417M23Rik|Atg6 MGI:1891828 11 11 D|11 beclin 1, autophagy related protein-coding beclin 1, autophagy related mmu-miR-30a predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and Becn1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 4229 mmu-miR-30c miR-30abcdef/30abe-5p/384-5p MIMAT0000514 miRNA Atg12 autophagy down Mus musculus prediction 10090 67526 4931423H11Rik|A330058M13Rik|Apg12l|Atg12l MGI:1914776|Ensembl:ENSMUSG00000032905 18 18 C|18 autophagy related 12 protein-coding autophagy related 12 mmu-miR-30c predicted by miR-30b (Homo sapiens), and Atg12 predicted by ATG12 (Homo sapiens) according to Pubmed ID (22647547),(23274497) 4230 mmu-let-7f let-7/98/4458/4500 MIMAT0000525 miRNA Olr1 autophagy down Mus musculus prediction 10090 108078 LOX-1|SR-EI|Scare1 MGI:1261434|Ensembl:ENSMUSG00000030162|Vega:OTTMUSG00000034583 6 6 F3|6 oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding oxidized low density lipoprotein (lectin-like) receptor 1 mmu-let-7f predicted by let-7g (Mus musculus), and Olr1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 4231 mmu-miR-148b miR-148ab-3p/152 MIMAT0000580 miRNA Atg14 autophagy down Mus musculus prediction 10090 100504663 4832427M01|Atg14L|D14Ertd114e|D14Ertd436e MGI:1261775|Ensembl:ENSMUSG00000037526 14 14 C1|14 24.6 cM autophagy related 14 protein-coding autophagy related 14 mmu-miR-148b predicted by miR-152 (Homo sapiens), and Atg14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (25650716) 4232 mmu-miR-291a-3p miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0000368 miRNA Atg7 autophagy down Mus musculus prediction 10090 74244 1810013K23Rik|Agp7|Apg7l|Atg7l|Gm21553 MGI:1921494|Ensembl:ENSMUSG00000030314|Vega:OTTMUSG00000043567 6 6 E3|6 autophagy related 7 protein-coding autophagy related 7 mmu-miR-291a-3p predicted by miR-291 (Mus musculus), and Atg7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 4233 mmu-miR-21 miR-21/590-5p MIMAT0000530 miRNA Bcl2 autophagy down Mus musculus prediction 10090 12043 AW986256|Bcl-2|C430015F12Rik|D630044D05Rik|D830018M01Rik MGI:88138|Ensembl:ENSMUSG00000057329|Vega:OTTMUSG00000022128 1 1 E2.1|1 49.76 cM B cell leukemia/lymphoma 2 protein-coding B cell leukemia/lymphoma 2 mmu-miR-21 predicted by miR-21 (Homo sapiens), and Bcl2 predicted by BCL2 (Homo sapiens) according to Pubmed ID (23834154) 4234 mmu-let-7c let-7/98/4458/4500 MIMAT0000523 miRNA Igf1r autophagy down Mus musculus prediction 10090 16001 A330103N21Rik|CD221|D930020L01|IGF-1R|hyft MGI:96433 7 7 D1|7 37.27 cM insulin-like growth factor I receptor protein-coding insulin-like growth factor I receptor mmu-let-7c predicted by let-7i (Homo sapiens), and Igf1r predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 4235 mmu-let-7b let-7/98/4458/4500 MIMAT0000522 miRNA Igf1r autophagy down Mus musculus prediction 10090 16001 A330103N21Rik|CD221|D930020L01|IGF-1R|hyft MGI:96433 7 7 D1|7 37.27 cM insulin-like growth factor I receptor protein-coding insulin-like growth factor I receptor mmu-let-7b predicted by let-7i (Homo sapiens), and Igf1r predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 4236 mmu-let-7f let-7/98/4458/4500 MIMAT0000525 miRNA Igf1r autophagy down Mus musculus prediction 10090 16001 A330103N21Rik|CD221|D930020L01|IGF-1R|hyft MGI:96433 7 7 D1|7 37.27 cM insulin-like growth factor I receptor protein-coding insulin-like growth factor I receptor mmu-let-7f predicted by let-7i (Homo sapiens), and Igf1r predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 4237 mmu-let-7f let-7/98/4458/4500 MIMAT0000525 miRNA Atg4b autophagy down Mus musculus prediction 10090 66615 2510009N07Rik|AW048066|Apg4b|Atg4bl|Autl1 MGI:1913865|Ensembl:ENSMUSG00000026280|Vega:OTTMUSG00000032629 1 1 D|1 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase mmu-let-7f predicted by let-7b (Homo sapiens), and Atg4b predicted by ATG4B (Homo sapiens) according to Pubmed ID (22135297) 4238 mmu-let-7d let-7/98/4458/4500 MIMAT0000383 miRNA Atg4b autophagy down Mus musculus prediction 10090 66615 2510009N07Rik|AW048066|Apg4b|Atg4bl|Autl1 MGI:1913865|Ensembl:ENSMUSG00000026280|Vega:OTTMUSG00000032629 1 1 D|1 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase mmu-let-7d predicted by let-7b (Homo sapiens), and Atg4b predicted by ATG4B (Homo sapiens) according to Pubmed ID (22135297) 4239 mmu-miR-449a miR-34ac/34bc-5p/449abc/449c-5p MIMAT0001542 miRNA Atg4b autophagy down Mus musculus prediction 10090 66615 2510009N07Rik|AW048066|Apg4b|Atg4bl|Autl1 MGI:1913865|Ensembl:ENSMUSG00000026280|Vega:OTTMUSG00000032629 1 1 D|1 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase mmu-miR-449a predicted by miR-34a (Homo sapiens), and Atg4b predicted by ATG4B (Homo sapiens) according to Pubmed ID (24755409) 4240 mmu-miR-98 let-7/98/4458/4500 MIMAT0000545 miRNA Olr1 autophagy down Mus musculus prediction 10090 108078 LOX-1|SR-EI|Scare1 MGI:1261434|Ensembl:ENSMUSG00000030162|Vega:OTTMUSG00000034583 6 6 F3|6 oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding oxidized low density lipoprotein (lectin-like) receptor 1 mmu-miR-98 predicted by let-7g (Mus musculus), and Olr1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 4241 mmu-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000529 miRNA Hif1a autophagy down Mus musculus prediction 10090 15251 AA959795|HIF1alpha|MOP1|bHLHe78 MGI:106918|Ensembl:ENSMUSG00000021109|Vega:OTTMUSG00000019740 12 12 C3|12 31.99 cM hypoxia inducible factor 1, alpha subunit protein-coding hypoxia inducible factor 1, alpha subunit mmu-miR-20a predicted by miR-20a (Homo sapiens), and Hif1a predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 4242 mmu-miR-322 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000548 miRNA Bag5 autophagy down Mus musculus prediction 10090 70369 1600025G07Rik|4930405J06Rik MGI:1917619|Ensembl:ENSMUSG00000049792|Vega:OTTMUSG00000028789 12 12 F2|12 BCL2-associated athanogene 5 protein-coding BCL2-associated athanogene 5 mmu-miR-322 predicted by miR-16 (Mus musculus), and Bag5 predicted by Bag5 (Mus musculus) according to Pubmed ID (21770019) 4243 mmu-miR-106a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000385 miRNA Fyco1 autophagy down Mus musculus prediction 10090 17281 2810409M01Rik|Mem2|RUFY3|ZFYVE7 MGI:107277|Ensembl:ENSMUSG00000025241|Vega:OTTMUSG00000044623 9 9 F|9 74.52 cM FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 mmu-miR-106a predicted by miR-93 (Homo sapiens), and Fyco1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 4244 mmu-miR-449b miR-34ac/34bc-5p/449abc/449c-5p MIMAT0005447 miRNA Atg4b autophagy down Mus musculus prediction 10090 66615 2510009N07Rik|AW048066|Apg4b|Atg4bl|Autl1 MGI:1913865|Ensembl:ENSMUSG00000026280|Vega:OTTMUSG00000032629 1 1 D|1 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase mmu-miR-449b predicted by miR-34a (Homo sapiens), and Atg4b predicted by ATG4B (Homo sapiens) according to Pubmed ID (24755409) 4245 mmu-miR-155 miR-155 MIMAT0000165 miRNA Gsk3b autophagy down Mus musculus prediction 10090 56637 7330414F15Rik|8430431H08Rik|C86142|GSK-3|GSK-3beta|GSK3 MGI:1861437|Ensembl:ENSMUSG00000022812|Vega:OTTMUSG00000016276 16 16|16 B4 glycogen synthase kinase 3 beta protein-coding glycogen synthase kinase 3 beta mmu-miR-155 predicted by miR-155 (Homo sapiens), and Gsk3b predicted by GSK3B (Homo sapiens) according to Pubmed ID (24343269) 4246 mmu-miR-99b miR-99ab/100 MIMAT0000132 miRNA Igf1r autophagy down Mus musculus prediction 10090 16001 A330103N21Rik|CD221|D930020L01|IGF-1R|hyft MGI:96433 7 7 D1|7 37.27 cM insulin-like growth factor I receptor protein-coding insulin-like growth factor I receptor mmu-miR-99b predicted by miR-100 (Homo sapiens), and Igf1r predicted by IGF1R (Homo sapiens) according to Pubmed ID (25026290) 4247 mmu-miR-30c miR-30abcdef/30abe-5p/384-5p MIMAT0000514 miRNA Bnip3l autophagy down Mus musculus prediction 10090 12177 C86132|D14Ertd719e|Nip3L|Nix MGI:1332659|Ensembl:ENSMUSG00000022051|Vega:OTTMUSG00000023686 14 14 D1|14 34.6 cM BCL2/adenovirus E1B interacting protein 3-like protein-coding BCL2/adenovirus E1B interacting protein 3-like mmu-miR-30c predicted by miR-30d (Homo sapiens), and Bnip3l predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 4248 mmu-miR-34c miR-34ac/34bc-5p/449abc/449c-5p MIMAT0000381 miRNA Atg9a autophagy down Mus musculus prediction 10090 245860 AU019532|Apg9l1|Atg9|Atg9l1 MGI:2138446|Ensembl:ENSMUSG00000033124 1 1 C3|1 autophagy related 9A protein-coding autophagy related 9A mmu-miR-34c predicted by miR-34a (Homo sapiens),miR-34a (Rattus norvegicus), and Atg9a predicted by Atg9a (Rattus norvegicus),ATG9A (Homo sapiens) according to Pubmed ID (22902544),(24728149),(24973144) 4249 mmu-miR-106a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000385 miRNA Atg16l1 autophagy down Mus musculus prediction 10090 77040 1500009K01Rik|Apg16l|Atg16l|WDR30 MGI:1924290|Ensembl:ENSMUSG00000026289|Vega:OTTMUSG00000016467 1 1 D|1 autophagy related 16-like 1 (S. cerevisiae) protein-coding autophagy related 16-like 1 (S. cerevisiae) mmu-miR-106a predicted by miR-106b (Homo sapiens), and Atg16l1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 4250 mmu-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000529 miRNA Atg16l1 autophagy down Mus musculus prediction 10090 77040 1500009K01Rik|Apg16l|Atg16l|WDR30 MGI:1924290|Ensembl:ENSMUSG00000026289|Vega:OTTMUSG00000016467 1 1 D|1 autophagy related 16-like 1 (S. cerevisiae) protein-coding autophagy related 16-like 1 (S. cerevisiae) mmu-miR-20a predicted by miR-106b (Homo sapiens), and Atg16l1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 4251 mmu-miR-101b miR-101/101ab MIMAT0000616 miRNA Ezh2 autophagy down Mus musculus prediction 10090 14056 Enx-1|Enx1h|KMT6|mKIAA4065 MGI:107940|Ensembl:ENSMUSG00000029687|Vega:OTTMUSG00000021193 6 6 B|6 22.92 cM enhancer of zeste homolog 2 (Drosophila) protein-coding enhancer of zeste homolog 2 (Drosophila) mmu-miR-101b predicted by miR-101 (Homo sapiens), and Ezh2 predicted by EZH2 (Homo sapiens) according to Pubmed ID (24211739) 4252 mmu-miR-294 miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0000372 miRNA Ulk1 autophagy down Mus musculus prediction 10090 22241 AU041434|Unc51.1|mKIAA0722 MGI:1270126|Ensembl:ENSMUSG00000029512 5 5|5 F unc-51 like kinase 1 protein-coding unc-51 like kinase 1 mmu-miR-294 predicted by miR-291 (Mus musculus), and Ulk1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 4253 mmu-miR-199a-5p miR-199ab-5p MIMAT0000229 miRNA Becn1 autophagy down Mus musculus prediction 10090 56208 4921513J16Rik|5430417M23Rik|Atg6 MGI:1891828 11 11 D|11 beclin 1, autophagy related protein-coding beclin 1, autophagy related mmu-miR-199a-5p predicted by miR-199a-5p (Homo sapiens), and Becn1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (23337876) 4254 mmu-miR-211 miR-204/204b/211 MIMAT0000668 miRNA Cav1 autophagy down Mus musculus prediction 10090 12389 Cav|Cav-1 MGI:102709|Ensembl:ENSMUSG00000007655|Vega:OTTMUSG00000024023 6 6|6 A2 caveolin 1, caveolae protein protein-coding caveolin 1, caveolae protein mmu-miR-211 predicted by miR-204 (Homo sapiens), and Cav1 predicted by CAV1 (Homo sapiens) according to Pubmed ID (25517751) 4255 mmu-miR-375 miR-375 MIMAT0000739 miRNA Rb1cc1 autophagy down Mus musculus prediction 10090 12421 2900055E04Rik|5930404L04Rik|Cc1|FIP200|LaXp180 MGI:1341850|Ensembl:ENSMUSG00000025907|Vega:OTTMUSG00000033467 1 1|1 A2 RB1-inducible coiled-coil 1 protein-coding RB1-inducible coiled-coil 1 mmu-miR-375 predicted by miR-375 (Homo sapiens), and Rb1cc1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (22135297) 4256 mmu-miR-335-5p miR-335/335-5p MIMAT0000766 miRNA Sqstm1 autophagy down Mus musculus prediction 10090 18412 A170|OSF-6|Osi|STAP|STONE14|p62 MGI:107931|Ensembl:ENSMUSG00000015837|Vega:OTTMUSG00000005574 11 11|11 B1.2 sequestosome 1 protein-coding sequestosome 1 mmu-miR-335-5p predicted by miR-335 (Homo sapiens), and Sqstm1 predicted by SQSTM1 (Homo sapiens) according to Pubmed ID (22135297) 4257 mmu-miR-429 miR-200bc/429/548a MIMAT0001537 miRNA Ubqln1 autophagy down Mus musculus prediction 10090 56085 1110046H03Rik|1810030E05Rik|AU019746|C77538|D13Ertd372e|Da41|Dsk2|Plic-1|Plic1|Xdrp1 MGI:1860276|Ensembl:ENSMUSG00000005312 13 13 B1|13 30.95 cM ubiquilin 1 protein-coding ubiquilin 1 mmu-miR-429 predicted by miR-200c (Homo sapiens), and Ubqln1 predicted by UBQLN1 (Homo sapiens) according to Pubmed ID (25044403) 4258 mmu-miR-24 miR-24/24ab/24-3p MIMAT0000219 miRNA Atg4a autophagy down Mus musculus prediction 10090 666468 AI627006|AV169859|Apg4a|Atg4al|Autl2 MGI:2147903|Ensembl:ENSMUSG00000079418|Vega:OTTMUSG00000018921 X X F1|X autophagy related 4A, cysteine peptidase protein-coding autophagy related 4A, cysteine peptidase mmu-miR-24 predicted by miR-24-3p (Homo sapiens), and Atg4a predicted by ATG4A (Homo sapiens) according to Pubmed ID (25426560) 4259 mmu-let-7b let-7/98/4458/4500 MIMAT0000522 miRNA Mtor autophagy down Mus musculus prediction 10090 56717 2610315D21Rik|AI327068|FRAP|FRAP2|Frap1|RAFT1|RAPT1|flat MGI:1928394|Ensembl:ENSMUSG00000028991|Vega:OTTMUSG00000010950 4 4 E1|4 78.76 cM mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) mmu-let-7b predicted by let-7 (Homo sapiens), and Mtor predicted by MTOR (Homo sapiens) according to Pubmed ID (25295787) 4260 mmu-miR-302b miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0003374 miRNA Atg7 autophagy down Mus musculus prediction 10090 74244 1810013K23Rik|Agp7|Apg7l|Atg7l|Gm21553 MGI:1921494|Ensembl:ENSMUSG00000030314|Vega:OTTMUSG00000043567 6 6 E3|6 autophagy related 7 protein-coding autophagy related 7 mmu-miR-302b predicted by miR-291 (Mus musculus), and Atg7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 4261 mmu-miR-199a-5p miR-199ab-5p MIMAT0000229 miRNA Hspa5 autophagy down Mus musculus prediction 10090 14828 AL022860|AU019543|Bip|D2Wsu141e|D2Wsu17e|Grp78|Hsce70|SEZ-7|Sez7|baffled|mBiP MGI:95835|Ensembl:ENSMUSG00000026864|Vega:OTTMUSG00000012014 2 2 B|2 22.94 cM heat shock protein 5 protein-coding heat shock protein 5 mmu-miR-199a-5p predicted by , and Hspa5 predicted by according to Pubmed ID (23598416) 4262 mmu-miR-421 miR-421 MIMAT0004869 miRNA Atg2b autophagy down Mus musculus prediction 10090 76559 2410024A21Rik|AI047755|AI503411|AW558123|C030004M05Rik|C630028L02Rik|mKIAA4067 MGI:1923809|Ensembl:ENSMUSG00000041341 12 12 E|12 autophagy related 2B protein-coding autophagy related 2B mmu-miR-421 predicted by miR-421 (Homo sapiens), and Atg2b predicted by ATG2B (Homo sapiens) according to Pubmed ID (20371350) 4263 mmu-miR-302d miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0003377 miRNA Atg7 autophagy down Mus musculus prediction 10090 74244 1810013K23Rik|Agp7|Apg7l|Atg7l|Gm21553 MGI:1921494|Ensembl:ENSMUSG00000030314|Vega:OTTMUSG00000043567 6 6 E3|6 autophagy related 7 protein-coding autophagy related 7 mmu-miR-302d predicted by miR-291 (Mus musculus), and Atg7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 4264 mmu-miR-302b miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0003374 miRNA Fyco1 autophagy down Mus musculus prediction 10090 17281 2810409M01Rik|Mem2|RUFY3|ZFYVE7 MGI:107277|Ensembl:ENSMUSG00000025241|Vega:OTTMUSG00000044623 9 9 F|9 74.52 cM FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 mmu-miR-302b predicted by miR-373 (Homo sapiens), and Fyco1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 4265 mmu-miR-30e miR-30abcdef/30abe-5p/384-5p MIMAT0000248 miRNA Bnip3l autophagy down Mus musculus prediction 10090 12177 C86132|D14Ertd719e|Nip3L|Nix MGI:1332659|Ensembl:ENSMUSG00000022051|Vega:OTTMUSG00000023686 14 14 D1|14 34.6 cM BCL2/adenovirus E1B interacting protein 3-like protein-coding BCL2/adenovirus E1B interacting protein 3-like mmu-miR-30e predicted by miR-30d (Homo sapiens), and Bnip3l predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 4266 mmu-let-7g let-7/98/4458/4500 MIMAT0000121 miRNA Atg4b autophagy down Mus musculus prediction 10090 66615 2510009N07Rik|AW048066|Apg4b|Atg4bl|Autl1 MGI:1913865|Ensembl:ENSMUSG00000026280|Vega:OTTMUSG00000032629 1 1 D|1 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase mmu-let-7g predicted by let-7b (Homo sapiens), and Atg4b predicted by ATG4B (Homo sapiens) according to Pubmed ID (22135297) 4267 mmu-miR-195 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000225 miRNA Bcl2l2 autophagy down Mus musculus prediction 10090 12050 AW048834|Bcl-w|Gtrgal2|Gtrosa41|bclw|c98 MGI:108052|Ensembl:ENSMUSG00000089682|Vega:OTTMUSG00000032812 14 14 C3|14 27.98 cM BCL2-like 2 protein-coding BCL2-like 2 mmu-miR-195 predicted by miR-15b (Mus musculus), and Bcl2l2 predicted by Bcl2l2 (Mus musculus) according to Pubmed ID (21770019) 4268 mmu-miR-92b miR-25/32/92abc/363/363-3p/367 MIMAT0004899 miRNA Ulk1 autophagy down Mus musculus prediction 10090 22241 AU041434|Unc51.1|mKIAA0722 MGI:1270126|Ensembl:ENSMUSG00000029512 5 5|5 F unc-51 like kinase 1 protein-coding unc-51 like kinase 1 mmu-miR-92b predicted by miR-25 (Homo sapiens), and Ulk1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (25026296) 4269 mmu-miR-34a miR-34ac/34bc-5p/449abc/449c-5p MIMAT0000542 miRNA Atg9a autophagy down Mus musculus prediction 10090 245860 AU019532|Apg9l1|Atg9|Atg9l1 MGI:2138446|Ensembl:ENSMUSG00000033124 1 1 C3|1 autophagy related 9A protein-coding autophagy related 9A mmu-miR-34a predicted by miR-34a (Homo sapiens),miR-34a (Rattus norvegicus), and Atg9a predicted by Atg9a (Rattus norvegicus),ATG9A (Homo sapiens) according to Pubmed ID (22902544),(24728149),(24973144) 4270 mmu-miR-144 miR-144 MIMAT0000156 miRNA Mtor autophagy down Mus musculus prediction 10090 56717 2610315D21Rik|AI327068|FRAP|FRAP2|Frap1|RAFT1|RAPT1|flat MGI:1928394|Ensembl:ENSMUSG00000028991|Vega:OTTMUSG00000010950 4 4 E1|4 78.76 cM mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) mmu-miR-144 predicted by miR-144 (Homo sapiens), and Mtor predicted by MTOR (Homo sapiens) according to Pubmed ID (25060662) 4271 mmu-miR-1961 let-7/98/4458/4500 MIMAT0009434 miRNA Igf1r autophagy down Mus musculus prediction 10090 16001 A330103N21Rik|CD221|D930020L01|IGF-1R|hyft MGI:96433 7 7 D1|7 37.27 cM insulin-like growth factor I receptor protein-coding insulin-like growth factor I receptor mmu-miR-1961 predicted by let-7i (Homo sapiens), and Igf1r predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 4272 mmu-miR-301a miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0000379 miRNA Atg2b autophagy down Mus musculus prediction 10090 76559 2410024A21Rik|AI047755|AI503411|AW558123|C030004M05Rik|C630028L02Rik|mKIAA4067 MGI:1923809|Ensembl:ENSMUSG00000041341 12 12 E|12 autophagy related 2B protein-coding autophagy related 2B mmu-miR-301a predicted by miR-130a (Homo sapiens), and Atg2b predicted by ATG2B (Homo sapiens) according to Pubmed ID (22902544) 4273 mmu-miR-497 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0003453 miRNA Atg14 autophagy down Mus musculus prediction 10090 100504663 4832427M01|Atg14L|D14Ertd114e|D14Ertd436e MGI:1261775|Ensembl:ENSMUSG00000037526 14 14 C1|14 24.6 cM autophagy related 14 protein-coding autophagy related 14 mmu-miR-497 predicted by miR-195 (Homo sapiens), and Atg14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 4274 mmu-miR-30c miR-30abcdef/30abe-5p/384-5p MIMAT0000514 miRNA Becn1 autophagy down Mus musculus prediction 10090 56208 4921513J16Rik|5430417M23Rik|Atg6 MGI:1891828 11 11 D|11 beclin 1, autophagy related protein-coding beclin 1, autophagy related mmu-miR-30c predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and Becn1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 4275 mmu-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003187 miRNA Sqstm1 autophagy down Mus musculus prediction 10090 18412 A170|OSF-6|Osi|STAP|STONE14|p62 MGI:107931|Ensembl:ENSMUSG00000015837|Vega:OTTMUSG00000005574 11 11|11 B1.2 sequestosome 1 protein-coding sequestosome 1 mmu-miR-20b predicted by miR-106b (Homo sapiens),miR-106 (Mus musculus), and Sqstm1 predicted by Sqstm1 (Mus musculus),SQSTM1 (Homo sapiens) according to Pubmed ID (21628417),(22441107),(25485521),(25617127) 4276 mmu-let-7g let-7/98/4458/4500 MIMAT0000121 miRNA Mtor autophagy down Mus musculus prediction 10090 56717 2610315D21Rik|AI327068|FRAP|FRAP2|Frap1|RAFT1|RAPT1|flat MGI:1928394|Ensembl:ENSMUSG00000028991|Vega:OTTMUSG00000010950 4 4 E1|4 78.76 cM mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) mmu-let-7g predicted by let-7 (Homo sapiens), and Mtor predicted by MTOR (Homo sapiens) according to Pubmed ID (25295787) 4277 mmu-let-7e let-7/98/4458/4500 MIMAT0000524 miRNA Atg4b autophagy down Mus musculus prediction 10090 66615 2510009N07Rik|AW048066|Apg4b|Atg4bl|Autl1 MGI:1913865|Ensembl:ENSMUSG00000026280|Vega:OTTMUSG00000032629 1 1 D|1 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase mmu-let-7e predicted by let-7b (Homo sapiens), and Atg4b predicted by ATG4B (Homo sapiens) according to Pubmed ID (22135297) 4278 mmu-miR-34b-5p miR-34ac/34bc-5p/449abc/449c-5p MIMAT0000382 miRNA Atg4b autophagy down Mus musculus prediction 10090 66615 2510009N07Rik|AW048066|Apg4b|Atg4bl|Autl1 MGI:1913865|Ensembl:ENSMUSG00000026280|Vega:OTTMUSG00000032629 1 1 D|1 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase mmu-miR-34b-5p predicted by miR-34a (Homo sapiens), and Atg4b predicted by ATG4B (Homo sapiens) according to Pubmed ID (24755409) 4279 mmu-miR-211 miR-204/204b/211 MIMAT0000668 miRNA Map1lc3b autophagy down Mus musculus prediction 10090 67443 1010001C15Rik|Atg8|LC3b|Map1lc3 MGI:1914693 8 8 E1|8 microtubule-associated protein 1 light chain 3 beta protein-coding microtubule-associated protein 1 light chain 3 beta mmu-miR-211 predicted by miR-204 (Homo sapiens),miR-204 (Rattus norvegicus), and Map1lc3b predicted by Map1lc3b (Rattus norvegicus),MAP1LC3B (Homo sapiens) according to Pubmed ID (21316776),(21631941),(22516261),(25209181),(25517751) 4280 mmu-miR-335-5p miR-335/335-5p MIMAT0000766 miRNA Ulk2 autophagy down Mus musculus prediction 10090 29869 A830085I22Rik|AU015340|Unc51.2|mKIAA0623 MGI:1352758|Ensembl:ENSMUSG00000004798|Vega:OTTMUSG00000005846 11 11 B2|11 unc-51 like kinase 2 protein-coding unc-51 like kinase 2 mmu-miR-335-5p predicted by miR-335 (Homo sapiens), and Ulk2 predicted by ULK2 (Homo sapiens) according to Pubmed ID (18185580) 4281 mmu-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000386 miRNA Sqstm1 autophagy down Mus musculus prediction 10090 18412 A170|OSF-6|Osi|STAP|STONE14|p62 MGI:107931|Ensembl:ENSMUSG00000015837|Vega:OTTMUSG00000005574 11 11|11 B1.2 sequestosome 1 protein-coding sequestosome 1 mmu-miR-106b predicted by miR-106b (Homo sapiens),miR-106 (Mus musculus), and Sqstm1 predicted by Sqstm1 (Mus musculus),SQSTM1 (Homo sapiens) according to Pubmed ID (21628417),(22441107),(25485521),(25617127) 4282 mmu-miR-17 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000649 miRNA Ulk1 autophagy down Mus musculus prediction 10090 22241 AU041434|Unc51.1|mKIAA0722 MGI:1270126|Ensembl:ENSMUSG00000029512 5 5|5 F unc-51 like kinase 1 protein-coding unc-51 like kinase 1 mmu-miR-17 predicted by miR-106b (Homo sapiens), and Ulk1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 4283 mmu-miR-100 miR-99ab/100 MIMAT0000655 miRNA Mtor autophagy down Mus musculus prediction 10090 56717 2610315D21Rik|AI327068|FRAP|FRAP2|Frap1|RAFT1|RAPT1|flat MGI:1928394|Ensembl:ENSMUSG00000028991|Vega:OTTMUSG00000010950 4 4 E1|4 78.76 cM mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) mmu-miR-100 predicted by miR-100 (Homo sapiens), and Mtor predicted by MTOR (Homo sapiens) according to Pubmed ID (25026290) 4284 mmu-miR-205 miR-205/205ab MIMAT0000238 miRNA Rab27a autophagy down Mus musculus prediction 10090 11891 2210402C08Rik|2410003M20Rik|4933437C11Rik|ash MGI:1861441|Ensembl:ENSMUSG00000032202|Vega:OTTMUSG00000044792 9 9 D|9 40.08 cM RAB27A, member RAS oncogene family protein-coding RAB27A, member RAS oncogene family mmu-miR-205 predicted by miR-205 (Homo sapiens), and Rab27a predicted by RAB27A (Homo sapiens) according to Pubmed ID (24370341) 4285 mmu-miR-93 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000540 miRNA Atg16l1 autophagy down Mus musculus prediction 10090 77040 1500009K01Rik|Apg16l|Atg16l|WDR30 MGI:1924290|Ensembl:ENSMUSG00000026289|Vega:OTTMUSG00000016467 1 1 D|1 autophagy related 16-like 1 (S. cerevisiae) protein-coding autophagy related 16-like 1 (S. cerevisiae) mmu-miR-93 predicted by miR-106b (Homo sapiens), and Atg16l1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 4286 mmu-miR-181c miR-181abcd/4262 MIMAT0000674 miRNA Atg5 autophagy down Mus musculus prediction 10090 11793 2010107M05Rik|3110067M24Rik|AW319544|Apg5l|Atg5l|C88337|Paddy MGI:1277186|Ensembl:ENSMUSG00000038160 10 10 B2|10 23.24 cM autophagy related 5 protein-coding autophagy related 5 mmu-miR-181c predicted by miR-181a (Homo sapiens), and Atg5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22356768),(22902544),(23322078) 4287 mmu-miR-96 miR-96/507/1271 MIMAT0000541 miRNA Mtor autophagy down Mus musculus prediction 10090 56717 2610315D21Rik|AI327068|FRAP|FRAP2|Frap1|RAFT1|RAPT1|flat MGI:1928394|Ensembl:ENSMUSG00000028991|Vega:OTTMUSG00000010950 4 4 E1|4 78.76 cM mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) mmu-miR-96 predicted by miR-96 (Homo sapiens), and Mtor predicted by MTOR (Homo sapiens) according to Pubmed ID (25333253) 4288 mmu-miR-322 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000548 miRNA Bcl2l2 autophagy down Mus musculus prediction 10090 12050 AW048834|Bcl-w|Gtrgal2|Gtrosa41|bclw|c98 MGI:108052|Ensembl:ENSMUSG00000089682|Vega:OTTMUSG00000032812 14 14 C3|14 27.98 cM BCL2-like 2 protein-coding BCL2-like 2 mmu-miR-322 predicted by miR-15b (Mus musculus), and Bcl2l2 predicted by Bcl2l2 (Mus musculus) according to Pubmed ID (21770019) 4289 mmu-miR-93 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000540 miRNA Sqstm1 autophagy down Mus musculus prediction 10090 18412 A170|OSF-6|Osi|STAP|STONE14|p62 MGI:107931|Ensembl:ENSMUSG00000015837|Vega:OTTMUSG00000005574 11 11|11 B1.2 sequestosome 1 protein-coding sequestosome 1 mmu-miR-93 predicted by miR-106b (Homo sapiens),miR-106 (Mus musculus), and Sqstm1 predicted by Sqstm1 (Mus musculus),SQSTM1 (Homo sapiens) according to Pubmed ID (21628417),(22441107),(25485521),(25617127) 4290 mmu-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000386 miRNA Fyco1 autophagy down Mus musculus prediction 10090 17281 2810409M01Rik|Mem2|RUFY3|ZFYVE7 MGI:107277|Ensembl:ENSMUSG00000025241|Vega:OTTMUSG00000044623 9 9 F|9 74.52 cM FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 mmu-miR-106b predicted by miR-93 (Homo sapiens), and Fyco1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 4291 mmu-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000529 miRNA Sqstm1 autophagy down Mus musculus prediction 10090 18412 A170|OSF-6|Osi|STAP|STONE14|p62 MGI:107931|Ensembl:ENSMUSG00000015837|Vega:OTTMUSG00000005574 11 11|11 B1.2 sequestosome 1 protein-coding sequestosome 1 mmu-miR-20a predicted by miR-106b (Homo sapiens),miR-106 (Mus musculus), and Sqstm1 predicted by Sqstm1 (Mus musculus),SQSTM1 (Homo sapiens) according to Pubmed ID (21628417),(22441107),(25485521),(25617127) 4292 mmu-miR-106a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000385 miRNA Sqstm1 autophagy down Mus musculus prediction 10090 18412 A170|OSF-6|Osi|STAP|STONE14|p62 MGI:107931|Ensembl:ENSMUSG00000015837|Vega:OTTMUSG00000005574 11 11|11 B1.2 sequestosome 1 protein-coding sequestosome 1 mmu-miR-106a predicted by miR-106b (Homo sapiens),miR-106 (Mus musculus), and Sqstm1 predicted by Sqstm1 (Mus musculus),SQSTM1 (Homo sapiens) according to Pubmed ID (21628417),(22441107),(25485521),(25617127) 4293 mmu-miR-101b miR-101/101ab MIMAT0000616 miRNA Rab5a autophagy down Mus musculus prediction 10090 271457 2410015H04Rik|AI663973|AU021172|nnyRab5a MGI:105926|Ensembl:ENSMUSG00000017831 17 17 C|17 27.82 cM RAB5A, member RAS oncogene family protein-coding RAB5A, member RAS oncogene family mmu-miR-101b predicted by miR-101 (Homo sapiens), and Rab5a predicted by RAB5A (Homo sapiens) according to Pubmed ID (21915098),(23483142),(25606826) 4294 mmu-miR-16 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000527 miRNA Bcl2l2 autophagy down Mus musculus prediction 10090 12050 AW048834|Bcl-w|Gtrgal2|Gtrosa41|bclw|c98 MGI:108052|Ensembl:ENSMUSG00000089682|Vega:OTTMUSG00000032812 14 14 C3|14 27.98 cM BCL2-like 2 protein-coding BCL2-like 2 mmu-miR-16 predicted by miR-15b (Mus musculus), and Bcl2l2 predicted by Bcl2l2 (Mus musculus) according to Pubmed ID (21770019) 4295 mmu-miR-152 miR-148ab-3p/152 MIMAT0000162 miRNA Atg14 autophagy down Mus musculus prediction 10090 100504663 4832427M01|Atg14L|D14Ertd114e|D14Ertd436e MGI:1261775|Ensembl:ENSMUSG00000037526 14 14 C1|14 24.6 cM autophagy related 14 protein-coding autophagy related 14 mmu-miR-152 predicted by miR-152 (Homo sapiens), and Atg14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (25650716) 4296 mmu-miR-384-5p miR-30abcdef/30abe-5p/384-5p MIMAT0004745 miRNA Atg5 autophagy down Mus musculus prediction 10090 11793 2010107M05Rik|3110067M24Rik|AW319544|Apg5l|Atg5l|C88337|Paddy MGI:1277186|Ensembl:ENSMUSG00000038160 10 10 B2|10 23.24 cM autophagy related 5 protein-coding autophagy related 5 mmu-miR-384-5p predicted by miR-30a (Homo sapiens), and Atg5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22395361),(22617440),(22902544),(23274497),(24148619) 4297 mmu-miR-302a miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0000380 miRNA Fyco1 autophagy down Mus musculus prediction 10090 17281 2810409M01Rik|Mem2|RUFY3|ZFYVE7 MGI:107277|Ensembl:ENSMUSG00000025241|Vega:OTTMUSG00000044623 9 9 F|9 74.52 cM FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 mmu-miR-302a predicted by miR-373 (Homo sapiens), and Fyco1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 4298 mmu-miR-7a miR-7/7ab MIMAT0000677 miRNA Egfr autophagy down Mus musculus prediction 10090 13649 9030024J15Rik|AI552599|Erbb|Errb1|Errp|Wa5|wa-2|wa2 MGI:95294|Ensembl:ENSMUSG00000020122|Vega:OTTMUSG00000005185 11 11 A1-A4|11 9.41 cM epidermal growth factor receptor protein-coding epidermal growth factor receptor mmu-miR-7a predicted by miR-7 (Homo sapiens), and Egfr predicted by EGFR (Homo sapiens) according to Pubmed ID (22492316) 4299 mmu-miR-106a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000385 miRNA Hif1a autophagy down Mus musculus prediction 10090 15251 AA959795|HIF1alpha|MOP1|bHLHe78 MGI:106918|Ensembl:ENSMUSG00000021109|Vega:OTTMUSG00000019740 12 12 C3|12 31.99 cM hypoxia inducible factor 1, alpha subunit protein-coding hypoxia inducible factor 1, alpha subunit mmu-miR-106a predicted by miR-20a (Homo sapiens), and Hif1a predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 4300 mmu-miR-322 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000548 miRNA Atg14 autophagy down Mus musculus prediction 10090 100504663 4832427M01|Atg14L|D14Ertd114e|D14Ertd436e MGI:1261775|Ensembl:ENSMUSG00000037526 14 14 C1|14 24.6 cM autophagy related 14 protein-coding autophagy related 14 mmu-miR-322 predicted by miR-195 (Homo sapiens), and Atg14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 4301 mmu-let-7e let-7/98/4458/4500 MIMAT0000524 miRNA Mtor autophagy down Mus musculus prediction 10090 56717 2610315D21Rik|AI327068|FRAP|FRAP2|Frap1|RAFT1|RAPT1|flat MGI:1928394|Ensembl:ENSMUSG00000028991|Vega:OTTMUSG00000010950 4 4 E1|4 78.76 cM mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) mmu-let-7e predicted by let-7 (Homo sapiens), and Mtor predicted by MTOR (Homo sapiens) according to Pubmed ID (25295787) 4302 mmu-let-7i let-7/98/4458/4500 MIMAT0000122 miRNA Atg4b autophagy down Mus musculus prediction 10090 66615 2510009N07Rik|AW048066|Apg4b|Atg4bl|Autl1 MGI:1913865|Ensembl:ENSMUSG00000026280|Vega:OTTMUSG00000032629 1 1 D|1 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase mmu-let-7i predicted by let-7b (Homo sapiens), and Atg4b predicted by ATG4B (Homo sapiens) according to Pubmed ID (22135297) 4303 mmu-miR-449a miR-34ac/34bc-5p/449abc/449c-5p MIMAT0001542 miRNA Atg9a autophagy down Mus musculus prediction 10090 245860 AU019532|Apg9l1|Atg9|Atg9l1 MGI:2138446|Ensembl:ENSMUSG00000033124 1 1 C3|1 autophagy related 9A protein-coding autophagy related 9A mmu-miR-449a predicted by miR-34a (Homo sapiens),miR-34a (Rattus norvegicus), and Atg9a predicted by Atg9a (Rattus norvegicus),ATG9A (Homo sapiens) according to Pubmed ID (22902544),(24728149),(24973144) 4304 mmu-miR-363-3p miR-25/32/92abc/363/363-3p/367 MIMAT0000708 miRNA Ulk1 autophagy down Mus musculus prediction 10090 22241 AU041434|Unc51.1|mKIAA0722 MGI:1270126|Ensembl:ENSMUSG00000029512 5 5|5 F unc-51 like kinase 1 protein-coding unc-51 like kinase 1 mmu-miR-363-3p predicted by miR-25 (Homo sapiens), and Ulk1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (25026296) 4305 mmu-miR-384-5p miR-30abcdef/30abe-5p/384-5p MIMAT0004745 miRNA Becn1 autophagy down Mus musculus prediction 10090 56208 4921513J16Rik|5430417M23Rik|Atg6 MGI:1891828 11 11 D|11 beclin 1, autophagy related protein-coding beclin 1, autophagy related mmu-miR-384-5p predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and Becn1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 4306 mmu-miR-130a miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0000141 miRNA Rb1cc1 autophagy down Mus musculus prediction 10090 12421 2900055E04Rik|5930404L04Rik|Cc1|FIP200|LaXp180 MGI:1341850|Ensembl:ENSMUSG00000025907|Vega:OTTMUSG00000033467 1 1|1 A2 RB1-inducible coiled-coil 1 protein-coding RB1-inducible coiled-coil 1 mmu-miR-130a predicted by miR-133b (Homo sapiens), and Rb1cc1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 4307 mmu-let-7c let-7/98/4458/4500 MIMAT0000523 miRNA Atg4b autophagy down Mus musculus prediction 10090 66615 2510009N07Rik|AW048066|Apg4b|Atg4bl|Autl1 MGI:1913865|Ensembl:ENSMUSG00000026280|Vega:OTTMUSG00000032629 1 1 D|1 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase mmu-let-7c predicted by let-7b (Homo sapiens), and Atg4b predicted by ATG4B (Homo sapiens) according to Pubmed ID (22135297) 4308 mmu-miR-99a miR-99ab/100 MIMAT0000131 miRNA Mtor autophagy down Mus musculus prediction 10090 56717 2610315D21Rik|AI327068|FRAP|FRAP2|Frap1|RAFT1|RAPT1|flat MGI:1928394|Ensembl:ENSMUSG00000028991|Vega:OTTMUSG00000010950 4 4 E1|4 78.76 cM mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) mmu-miR-99a predicted by miR-100 (Homo sapiens), and Mtor predicted by MTOR (Homo sapiens) according to Pubmed ID (25026290) 4309 mmu-miR-30e miR-30abcdef/30abe-5p/384-5p MIMAT0000248 miRNA Atg12 autophagy down Mus musculus prediction 10090 67526 4931423H11Rik|A330058M13Rik|Apg12l|Atg12l MGI:1914776|Ensembl:ENSMUSG00000032905 18 18 C|18 autophagy related 12 protein-coding autophagy related 12 mmu-miR-30e predicted by miR-30b (Homo sapiens), and Atg12 predicted by ATG12 (Homo sapiens) according to Pubmed ID (22647547),(23274497) 4310 mmu-miR-132 miR-132/212/212-3p MIMAT0000144 miRNA Foxo3 autophagy down Mus musculus prediction 10090 56484 1110048B16Rik|2010203A17Rik|C76856|FKHRL1|Fkhr2|Foxo3a MGI:1890081|Ensembl:ENSMUSG00000048756|Vega:OTTMUSG00000020929 10 10 B2|10 22.79 cM forkhead box O3 protein-coding forkhead box O3 mmu-miR-132 predicted by miR-212 (Mus musculus), and Foxo3 predicted by Foxo3 (Mus musculus) according to Pubmed ID (23011132) 4311 mmu-miR-1907 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0007876 miRNA Atg14 autophagy down Mus musculus prediction 10090 100504663 4832427M01|Atg14L|D14Ertd114e|D14Ertd436e MGI:1261775|Ensembl:ENSMUSG00000037526 14 14 C1|14 24.6 cM autophagy related 14 protein-coding autophagy related 14 mmu-miR-1907 predicted by miR-195 (Homo sapiens), and Atg14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 4312 mmu-miR-375 miR-375 MIMAT0000739 miRNA Ywhaz autophagy down Mus musculus prediction 10090 22631 1110013I11Rik|14-3-3zeta|AI596267|AL022924|AU020854 MGI:109484|Ensembl:ENSMUSG00000022285|Vega:OTTMUSG00000017005 15 15 B3.1|15 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide protein-coding tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide mmu-miR-375 predicted by miR-375 (Homo sapiens), and Ywhaz predicted by YWHAZ (Homo sapiens) according to Pubmed ID (22606351) 4313 mmu-miR-30b miR-30abcdef/30abe-5p/384-5p MIMAT0000130 miRNA Atg5 autophagy down Mus musculus prediction 10090 11793 2010107M05Rik|3110067M24Rik|AW319544|Apg5l|Atg5l|C88337|Paddy MGI:1277186|Ensembl:ENSMUSG00000038160 10 10 B2|10 23.24 cM autophagy related 5 protein-coding autophagy related 5 mmu-miR-30b predicted by miR-30a (Homo sapiens), and Atg5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22395361),(22617440),(22902544),(23274497),(24148619) 4314 mmu-miR-155 miR-155 MIMAT0000165 miRNA Gabarapl1 autophagy down Mus musculus prediction 10090 57436 3110025G09Rik|9130422N19Rik|AI196471|Apg8l|Atg8l|GECI MGI:1914980|Ensembl:ENSMUSG00000030161 6 6 F3|6 gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1 protein-coding gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1 mmu-miR-155 predicted by miR-155 (Homo sapiens), and Gabarapl1 predicted by GABARAPL1 (Homo sapiens) according to Pubmed ID (20584899) 4315 mmu-miR-497 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0003453 miRNA Bag5 autophagy down Mus musculus prediction 10090 70369 1600025G07Rik|4930405J06Rik MGI:1917619|Ensembl:ENSMUSG00000049792|Vega:OTTMUSG00000028789 12 12 F2|12 BCL2-associated athanogene 5 protein-coding BCL2-associated athanogene 5 mmu-miR-497 predicted by miR-16 (Mus musculus), and Bag5 predicted by Bag5 (Mus musculus) according to Pubmed ID (21770019) 4316 mmu-miR-221 miR-221/222/222ab/1928 MIMAT0000669 miRNA Cdkn1b autophagy down Mus musculus prediction 10090 12576 AA408329|AI843786|Kip1|p27|p27Kip1 MGI:104565|Ensembl:ENSMUSG00000003031|Vega:OTTMUSG00000021172 6 6 G1|6 65.77 cM cyclin-dependent kinase inhibitor 1B protein-coding cyclin-dependent kinase inhibitor 1B mmu-miR-221 predicted by miR-221 (Homo sapiens), and Cdkn1b predicted by CDKN1B (Homo sapiens) according to Pubmed ID (25394488) 4317 mmu-let-7e let-7/98/4458/4500 MIMAT0000524 miRNA Igf1r autophagy down Mus musculus prediction 10090 16001 A330103N21Rik|CD221|D930020L01|IGF-1R|hyft MGI:96433 7 7 D1|7 37.27 cM insulin-like growth factor I receptor protein-coding insulin-like growth factor I receptor mmu-let-7e predicted by let-7i (Homo sapiens), and Igf1r predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 4318 mmu-miR-181d miR-181abcd/4262 MIMAT0004324 miRNA Atg5 autophagy down Mus musculus prediction 10090 11793 2010107M05Rik|3110067M24Rik|AW319544|Apg5l|Atg5l|C88337|Paddy MGI:1277186|Ensembl:ENSMUSG00000038160 10 10 B2|10 23.24 cM autophagy related 5 protein-coding autophagy related 5 mmu-miR-181d predicted by miR-181a (Homo sapiens), and Atg5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22356768),(22902544),(23322078) 4319 mmu-miR-182 miR-182 MIMAT0000211 miRNA Bcl2 autophagy down Mus musculus prediction 10090 12043 AW986256|Bcl-2|C430015F12Rik|D630044D05Rik|D830018M01Rik MGI:88138|Ensembl:ENSMUSG00000057329|Vega:OTTMUSG00000022128 1 1 E2.1|1 49.76 cM B cell leukemia/lymphoma 2 protein-coding B cell leukemia/lymphoma 2 mmu-miR-182 predicted by miR-182 (Homo sapiens), and Bcl2 predicted by BCL2 (Homo sapiens) according to Pubmed ID (23936432) 4320 mmu-miR-30e miR-30abcdef/30abe-5p/384-5p MIMAT0000248 miRNA Becn1 autophagy down Mus musculus prediction 10090 56208 4921513J16Rik|5430417M23Rik|Atg6 MGI:1891828 11 11 D|11 beclin 1, autophagy related protein-coding beclin 1, autophagy related mmu-miR-30e predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and Becn1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 4321 mmu-miR-1928 miR-221/222/222ab/1928 MIMAT0009391 miRNA Cdkn1b autophagy down Mus musculus prediction 10090 12576 AA408329|AI843786|Kip1|p27|p27Kip1 MGI:104565|Ensembl:ENSMUSG00000003031|Vega:OTTMUSG00000021172 6 6 G1|6 65.77 cM cyclin-dependent kinase inhibitor 1B protein-coding cyclin-dependent kinase inhibitor 1B mmu-miR-1928 predicted by miR-221 (Homo sapiens), and Cdkn1b predicted by CDKN1B (Homo sapiens) according to Pubmed ID (25394488) 4322 mmu-miR-130b miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0000387 miRNA Atg2b autophagy down Mus musculus prediction 10090 76559 2410024A21Rik|AI047755|AI503411|AW558123|C030004M05Rik|C630028L02Rik|mKIAA4067 MGI:1923809|Ensembl:ENSMUSG00000041341 12 12 E|12 autophagy related 2B protein-coding autophagy related 2B mmu-miR-130b predicted by miR-130a (Homo sapiens), and Atg2b predicted by ATG2B (Homo sapiens) according to Pubmed ID (22902544) 4323 mmu-miR-22 miR-22/22-3p MIMAT0000531 miRNA Btg1 autophagy down Mus musculus prediction 10090 12226 AI426953|AW546738 MGI:88215|Ensembl:ENSMUSG00000036478 10 10 C3|10 B cell translocation gene 1, anti-proliferative protein-coding B cell translocation gene 1, anti-proliferative mmu-miR-22 predicted by miR-22 (Homo sapiens), and Btg1 predicted by BTG1 (Homo sapiens) according to Pubmed ID (25449431) 4324 mmu-miR-590-5p miR-21/590-5p MIMAT0004895 miRNA Bcl2 autophagy down Mus musculus prediction 10090 12043 AW986256|Bcl-2|C430015F12Rik|D630044D05Rik|D830018M01Rik MGI:88138|Ensembl:ENSMUSG00000057329|Vega:OTTMUSG00000022128 1 1 E2.1|1 49.76 cM B cell leukemia/lymphoma 2 protein-coding B cell leukemia/lymphoma 2 mmu-miR-590-5p predicted by miR-21 (Homo sapiens), and Bcl2 predicted by BCL2 (Homo sapiens) according to Pubmed ID (23834154) 4325 mmu-miR-216b miR-216b/216b-5p MIMAT0003729 miRNA Becn1 autophagy down Mus musculus prediction 10090 56208 4921513J16Rik|5430417M23Rik|Atg6 MGI:1891828 11 11 D|11 beclin 1, autophagy related protein-coding beclin 1, autophagy related mmu-miR-216b predicted by miR-216b (Homo sapiens), and Becn1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (24681041) 4326 mmu-miR-204 miR-204/204b/211 MIMAT0000237 miRNA Vhl autophagy down Mus musculus prediction 10090 22346 Vhlh MGI:103223|Ensembl:ENSMUSG00000033933|Vega:OTTMUSG00000024147 6 6 E3|6 52.81 cM von Hippel-Lindau tumor suppressor protein-coding von Hippel-Lindau tumor suppressor mmu-miR-204 predicted by miR-204 (Homo sapiens), and Vhl predicted by VHL (Homo sapiens) according to Pubmed ID (25517751) 4327 mmu-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003187 miRNA Fyco1 autophagy down Mus musculus prediction 10090 17281 2810409M01Rik|Mem2|RUFY3|ZFYVE7 MGI:107277|Ensembl:ENSMUSG00000025241|Vega:OTTMUSG00000044623 9 9 F|9 74.52 cM FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 mmu-miR-20b predicted by miR-93 (Homo sapiens), and Fyco1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 4328 mmu-miR-375 miR-375 MIMAT0000739 miRNA Sp1 autophagy down Mus musculus prediction 10090 20683 1110003E12Rik|AA450830|AI845540|Sp1-1 MGI:98372|Ensembl:ENSMUSG00000001280|Vega:OTTMUSG00000035159 15 15 F3|15 trans-acting transcription factor 1 protein-coding trans-acting transcription factor 1 mmu-miR-375 predicted by miR-375 (Homo sapiens), and Sp1 predicted by SP1 (Homo sapiens) according to Pubmed ID (22606351) 4329 mmu-miR-302d miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0003377 miRNA Fyco1 autophagy down Mus musculus prediction 10090 17281 2810409M01Rik|Mem2|RUFY3|ZFYVE7 MGI:107277|Ensembl:ENSMUSG00000025241|Vega:OTTMUSG00000044623 9 9 F|9 74.52 cM FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 mmu-miR-302d predicted by miR-373 (Homo sapiens), and Fyco1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 4330 mmu-miR-30a miR-30abcdef/30abe-5p/384-5p MIMAT0000128 miRNA Atg12 autophagy down Mus musculus prediction 10090 67526 4931423H11Rik|A330058M13Rik|Apg12l|Atg12l MGI:1914776|Ensembl:ENSMUSG00000032905 18 18 C|18 autophagy related 12 protein-coding autophagy related 12 mmu-miR-30a predicted by miR-30b (Homo sapiens), and Atg12 predicted by ATG12 (Homo sapiens) according to Pubmed ID (22647547),(23274497) 4331 mmu-miR-204 miR-204/204b/211 MIMAT0000237 miRNA Map1lc3b autophagy down Mus musculus prediction 10090 67443 1010001C15Rik|Atg8|LC3b|Map1lc3 MGI:1914693 8 8 E1|8 microtubule-associated protein 1 light chain 3 beta protein-coding microtubule-associated protein 1 light chain 3 beta mmu-miR-204 predicted by miR-204 (Homo sapiens),miR-204 (Rattus norvegicus), and Map1lc3b predicted by Map1lc3b (Rattus norvegicus),MAP1LC3B (Homo sapiens) according to Pubmed ID (21316776),(21631941),(22516261),(25209181),(25517751) 4332 mmu-miR-222 miR-221/222/222ab/1928 MIMAT0000670 miRNA Cdkn1b autophagy down Mus musculus prediction 10090 12576 AA408329|AI843786|Kip1|p27|p27Kip1 MGI:104565|Ensembl:ENSMUSG00000003031|Vega:OTTMUSG00000021172 6 6 G1|6 65.77 cM cyclin-dependent kinase inhibitor 1B protein-coding cyclin-dependent kinase inhibitor 1B mmu-miR-222 predicted by miR-221 (Homo sapiens), and Cdkn1b predicted by CDKN1B (Homo sapiens) according to Pubmed ID (25394488) 4333 mmu-let-7d let-7/98/4458/4500 MIMAT0000383 miRNA Igf1r autophagy down Mus musculus prediction 10090 16001 A330103N21Rik|CD221|D930020L01|IGF-1R|hyft MGI:96433 7 7 D1|7 37.27 cM insulin-like growth factor I receptor protein-coding insulin-like growth factor I receptor mmu-let-7d predicted by let-7i (Homo sapiens), and Igf1r predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 4334 mmu-miR-15a miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000526 miRNA Atg14 autophagy down Mus musculus prediction 10090 100504663 4832427M01|Atg14L|D14Ertd114e|D14Ertd436e MGI:1261775|Ensembl:ENSMUSG00000037526 14 14 C1|14 24.6 cM autophagy related 14 protein-coding autophagy related 14 mmu-miR-15a predicted by miR-195 (Homo sapiens), and Atg14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 4335 mmu-miR-302a miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0000380 miRNA Ulk1 autophagy down Mus musculus prediction 10090 22241 AU041434|Unc51.1|mKIAA0722 MGI:1270126|Ensembl:ENSMUSG00000029512 5 5|5 F unc-51 like kinase 1 protein-coding unc-51 like kinase 1 mmu-miR-302a predicted by miR-291 (Mus musculus), and Ulk1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 4336 mmu-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000386 miRNA Atg7 autophagy down Mus musculus prediction 10090 74244 1810013K23Rik|Agp7|Apg7l|Atg7l|Gm21553 MGI:1921494|Ensembl:ENSMUSG00000030314|Vega:OTTMUSG00000043567 6 6 E3|6 autophagy related 7 protein-coding autophagy related 7 mmu-miR-106b predicted by miR-17 (Homo sapiens), and Atg7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 4337 mmu-miR-96 miR-96/507/1271 MIMAT0000541 miRNA Atg7 autophagy down Mus musculus prediction 10090 74244 1810013K23Rik|Agp7|Apg7l|Atg7l|Gm21553 MGI:1921494|Ensembl:ENSMUSG00000030314|Vega:OTTMUSG00000043567 6 6 E3|6 autophagy related 7 protein-coding autophagy related 7 mmu-miR-96 predicted by miR-96 (Homo sapiens), and Atg7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (25333253) 4338 mmu-miR-182 miR-182 MIMAT0000211 miRNA Foxo3 autophagy down Mus musculus prediction 10090 56484 1110048B16Rik|2010203A17Rik|C76856|FKHRL1|Fkhr2|Foxo3a MGI:1890081|Ensembl:ENSMUSG00000048756|Vega:OTTMUSG00000020929 10 10 B2|10 22.79 cM forkhead box O3 protein-coding forkhead box O3 mmu-miR-182 predicted by miR-182 (Homo sapiens), and Foxo3 predicted by FOXO3 (Homo sapiens) according to Pubmed ID (24871856) 4339 mmu-miR-99a miR-99ab/100 MIMAT0000131 miRNA Igf1r autophagy down Mus musculus prediction 10090 16001 A330103N21Rik|CD221|D930020L01|IGF-1R|hyft MGI:96433 7 7 D1|7 37.27 cM insulin-like growth factor I receptor protein-coding insulin-like growth factor I receptor mmu-miR-99a predicted by miR-100 (Homo sapiens), and Igf1r predicted by IGF1R (Homo sapiens) according to Pubmed ID (25026290) 4340 mmu-miR-100 miR-99ab/100 MIMAT0000655 miRNA Igf1r autophagy down Mus musculus prediction 10090 16001 A330103N21Rik|CD221|D930020L01|IGF-1R|hyft MGI:96433 7 7 D1|7 37.27 cM insulin-like growth factor I receptor protein-coding insulin-like growth factor I receptor mmu-miR-100 predicted by miR-100 (Homo sapiens), and Igf1r predicted by IGF1R (Homo sapiens) according to Pubmed ID (25026290) 4341 mmu-let-7i let-7/98/4458/4500 MIMAT0000122 miRNA Mtor autophagy down Mus musculus prediction 10090 56717 2610315D21Rik|AI327068|FRAP|FRAP2|Frap1|RAFT1|RAPT1|flat MGI:1928394|Ensembl:ENSMUSG00000028991|Vega:OTTMUSG00000010950 4 4 E1|4 78.76 cM mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) mmu-let-7i predicted by let-7 (Homo sapiens), and Mtor predicted by MTOR (Homo sapiens) according to Pubmed ID (25295787) 4342 mmu-miR-195 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000225 miRNA Bag5 autophagy down Mus musculus prediction 10090 70369 1600025G07Rik|4930405J06Rik MGI:1917619|Ensembl:ENSMUSG00000049792|Vega:OTTMUSG00000028789 12 12 F2|12 BCL2-associated athanogene 5 protein-coding BCL2-associated athanogene 5 mmu-miR-195 predicted by miR-16 (Mus musculus), and Bag5 predicted by Bag5 (Mus musculus) according to Pubmed ID (21770019) 4343 mmu-miR-1961 let-7/98/4458/4500 MIMAT0009434 miRNA Olr1 autophagy down Mus musculus prediction 10090 108078 LOX-1|SR-EI|Scare1 MGI:1261434|Ensembl:ENSMUSG00000030162|Vega:OTTMUSG00000034583 6 6 F3|6 oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding oxidized low density lipoprotein (lectin-like) receptor 1 mmu-miR-1961 predicted by let-7g (Mus musculus), and Olr1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 4344 mmu-miR-155 miR-155 MIMAT0000165 miRNA Atg3 autophagy down Mus musculus prediction 10090 67841 2610016C12Rik|APG3|Apg3l|Atg3l|PC3-96 MGI:1915091|Ensembl:ENSMUSG00000022663|Vega:OTTMUSG00000025355 16 16|16 B5 autophagy related 3 protein-coding autophagy related 3 mmu-miR-155 predicted by miR-155 (Homo sapiens), and Atg3 predicted by ATG3 (Homo sapiens) according to Pubmed ID (22135297) 4345 mmu-let-7a let-7/98/4458/4500 MIMAT0000521 miRNA Mtor autophagy down Mus musculus prediction 10090 56717 2610315D21Rik|AI327068|FRAP|FRAP2|Frap1|RAFT1|RAPT1|flat MGI:1928394|Ensembl:ENSMUSG00000028991|Vega:OTTMUSG00000010950 4 4 E1|4 78.76 cM mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) mmu-let-7a predicted by let-7 (Homo sapiens), and Mtor predicted by MTOR (Homo sapiens) according to Pubmed ID (25295787) 4346 mmu-miR-93 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000540 miRNA Ulk1 autophagy down Mus musculus prediction 10090 22241 AU041434|Unc51.1|mKIAA0722 MGI:1270126|Ensembl:ENSMUSG00000029512 5 5|5 F unc-51 like kinase 1 protein-coding unc-51 like kinase 1 mmu-miR-93 predicted by miR-106b (Homo sapiens), and Ulk1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 4347 mmu-miR-34b-5p miR-34ac/34bc-5p/449abc/449c-5p MIMAT0000382 miRNA Atg9a autophagy down Mus musculus prediction 10090 245860 AU019532|Apg9l1|Atg9|Atg9l1 MGI:2138446|Ensembl:ENSMUSG00000033124 1 1 C3|1 autophagy related 9A protein-coding autophagy related 9A mmu-miR-34b-5p predicted by miR-34a (Homo sapiens),miR-34a (Rattus norvegicus), and Atg9a predicted by Atg9a (Rattus norvegicus),ATG9A (Homo sapiens) according to Pubmed ID (22902544),(24728149),(24973144) 4348 mmu-miR-30c miR-30abcdef/30abe-5p/384-5p MIMAT0000514 miRNA Atg5 autophagy down Mus musculus prediction 10090 11793 2010107M05Rik|3110067M24Rik|AW319544|Apg5l|Atg5l|C88337|Paddy MGI:1277186|Ensembl:ENSMUSG00000038160 10 10 B2|10 23.24 cM autophagy related 5 protein-coding autophagy related 5 mmu-miR-30c predicted by miR-30a (Homo sapiens), and Atg5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22395361),(22617440),(22902544),(23274497),(24148619) 4349 mmu-miR-142-3p miR-142-3p MIMAT0000155 miRNA Atg16l1 autophagy down Mus musculus prediction 10090 77040 1500009K01Rik|Apg16l|Atg16l|WDR30 MGI:1924290|Ensembl:ENSMUSG00000026289|Vega:OTTMUSG00000016467 1 1 D|1 autophagy related 16-like 1 (S. cerevisiae) protein-coding autophagy related 16-like 1 (S. cerevisiae) mmu-miR-142-3p predicted by miR-142-3p (Homo sapiens), and Atg16l1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (24401604) 4350 mmu-miR-32 miR-25/32/92abc/363/363-3p/367 MIMAT0000654 miRNA Ulk1 autophagy down Mus musculus prediction 10090 22241 AU041434|Unc51.1|mKIAA0722 MGI:1270126|Ensembl:ENSMUSG00000029512 5 5|5 F unc-51 like kinase 1 protein-coding unc-51 like kinase 1 mmu-miR-32 predicted by miR-25 (Homo sapiens), and Ulk1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (25026296) 4351 mmu-miR-106a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000385 miRNA Ulk1 autophagy down Mus musculus prediction 10090 22241 AU041434|Unc51.1|mKIAA0722 MGI:1270126|Ensembl:ENSMUSG00000029512 5 5|5 F unc-51 like kinase 1 protein-coding unc-51 like kinase 1 mmu-miR-106a predicted by miR-106b (Homo sapiens), and Ulk1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 4352 mmu-miR-215 miR-192/215 MIMAT0000904 miRNA Atg4a autophagy down Mus musculus prediction 10090 666468 AI627006|AV169859|Apg4a|Atg4al|Autl2 MGI:2147903|Ensembl:ENSMUSG00000079418|Vega:OTTMUSG00000018921 X X F1|X autophagy related 4A, cysteine peptidase protein-coding autophagy related 4A, cysteine peptidase mmu-miR-215 predicted by miR-192 (Homo sapiens), and Atg4a predicted by ATG4A (Homo sapiens) according to Pubmed ID (19074876) 4353 mmu-miR-98 let-7/98/4458/4500 MIMAT0000545 miRNA Igf1r autophagy down Mus musculus prediction 10090 16001 A330103N21Rik|CD221|D930020L01|IGF-1R|hyft MGI:96433 7 7 D1|7 37.27 cM insulin-like growth factor I receptor protein-coding insulin-like growth factor I receptor mmu-miR-98 predicted by let-7i (Homo sapiens), and Igf1r predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 4354 mmu-miR-101a miR-101/101ab MIMAT0000133 miRNA Rab5a autophagy down Mus musculus prediction 10090 271457 2410015H04Rik|AI663973|AU021172|nnyRab5a MGI:105926|Ensembl:ENSMUSG00000017831 17 17 C|17 27.82 cM RAB5A, member RAS oncogene family protein-coding RAB5A, member RAS oncogene family mmu-miR-101a predicted by miR-101 (Homo sapiens), and Rab5a predicted by RAB5A (Homo sapiens) according to Pubmed ID (21915098),(23483142),(25606826) 4355 mmu-let-7c let-7/98/4458/4500 MIMAT0000523 miRNA Olr1 autophagy down Mus musculus prediction 10090 108078 LOX-1|SR-EI|Scare1 MGI:1261434|Ensembl:ENSMUSG00000030162|Vega:OTTMUSG00000034583 6 6 F3|6 oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding oxidized low density lipoprotein (lectin-like) receptor 1 mmu-let-7c predicted by let-7g (Mus musculus), and Olr1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 4356 mmu-miR-15b miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000124 miRNA Bag5 autophagy down Mus musculus prediction 10090 70369 1600025G07Rik|4930405J06Rik MGI:1917619|Ensembl:ENSMUSG00000049792|Vega:OTTMUSG00000028789 12 12 F2|12 BCL2-associated athanogene 5 protein-coding BCL2-associated athanogene 5 mmu-miR-15b predicted by miR-16 (Mus musculus), and Bag5 predicted by Bag5 (Mus musculus) according to Pubmed ID (21770019) 4357 mmu-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000386 miRNA Hif1a autophagy down Mus musculus prediction 10090 15251 AA959795|HIF1alpha|MOP1|bHLHe78 MGI:106918|Ensembl:ENSMUSG00000021109|Vega:OTTMUSG00000019740 12 12 C3|12 31.99 cM hypoxia inducible factor 1, alpha subunit protein-coding hypoxia inducible factor 1, alpha subunit mmu-miR-106b predicted by miR-20a (Homo sapiens), and Hif1a predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 4358 mmu-miR-384-5p miR-30abcdef/30abe-5p/384-5p MIMAT0004745 miRNA Bnip3l autophagy down Mus musculus prediction 10090 12177 C86132|D14Ertd719e|Nip3L|Nix MGI:1332659|Ensembl:ENSMUSG00000022051|Vega:OTTMUSG00000023686 14 14 D1|14 34.6 cM BCL2/adenovirus E1B interacting protein 3-like protein-coding BCL2/adenovirus E1B interacting protein 3-like mmu-miR-384-5p predicted by miR-30d (Homo sapiens), and Bnip3l predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 4359 mmu-miR-302b miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0003374 miRNA Ulk1 autophagy down Mus musculus prediction 10090 22241 AU041434|Unc51.1|mKIAA0722 MGI:1270126|Ensembl:ENSMUSG00000029512 5 5|5 F unc-51 like kinase 1 protein-coding unc-51 like kinase 1 mmu-miR-302b predicted by miR-291 (Mus musculus), and Ulk1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 4360 mmu-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003187 miRNA Atg16l1 autophagy down Mus musculus prediction 10090 77040 1500009K01Rik|Apg16l|Atg16l|WDR30 MGI:1924290|Ensembl:ENSMUSG00000026289|Vega:OTTMUSG00000016467 1 1 D|1 autophagy related 16-like 1 (S. cerevisiae) protein-coding autophagy related 16-like 1 (S. cerevisiae) mmu-miR-20b predicted by miR-106b (Homo sapiens), and Atg16l1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 4361 mmu-miR-15a miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000526 miRNA Bcl2l2 autophagy down Mus musculus prediction 10090 12050 AW048834|Bcl-w|Gtrgal2|Gtrosa41|bclw|c98 MGI:108052|Ensembl:ENSMUSG00000089682|Vega:OTTMUSG00000032812 14 14 C3|14 27.98 cM BCL2-like 2 protein-coding BCL2-like 2 mmu-miR-15a predicted by miR-15b (Mus musculus), and Bcl2l2 predicted by Bcl2l2 (Mus musculus) according to Pubmed ID (21770019) 4362 mmu-miR-155 miR-155 MIMAT0000165 miRNA Rictor autophagy down Mus musculus prediction 10090 78757 4921505C17Rik|6030405M08Rik|AVO3|AW492497|D530039E11Rik MGI:1926007|Ensembl:ENSMUSG00000050310 15 15 A1|15 RPTOR independent companion of MTOR, complex 2 protein-coding RPTOR independent companion of MTOR, complex 2 mmu-miR-155 predicted by miR-155 (Homo sapiens), and Rictor predicted by RICTOR (Homo sapiens) according to Pubmed ID (24262949) 4363 mmu-let-7a let-7/98/4458/4500 MIMAT0000521 miRNA Atg4b autophagy down Mus musculus prediction 10090 66615 2510009N07Rik|AW048066|Apg4b|Atg4bl|Autl1 MGI:1913865|Ensembl:ENSMUSG00000026280|Vega:OTTMUSG00000032629 1 1 D|1 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase mmu-let-7a predicted by let-7b (Homo sapiens), and Atg4b predicted by ATG4B (Homo sapiens) according to Pubmed ID (22135297) 4364 mmu-miR-224 miR-224 MIMAT0000671 miRNA Smad4 autophagy down Mus musculus prediction 10090 17128 AW743858|D18Wsu70e|DPC4|Madh4 MGI:894293|Ensembl:ENSMUSG00000024515|Vega:OTTMUSG00000021090 18 18 E2|18 49.51 cM SMAD family member 4 protein-coding SMAD family member 4 mmu-miR-224 predicted by miR-224 (Homo sapiens), and Smad4 predicted by SMAD4 (Homo sapiens) according to Pubmed ID (23913306),(25068270) 4365 mmu-miR-101a miR-101/101ab MIMAT0000133 miRNA Ezh2 autophagy down Mus musculus prediction 10090 14056 Enx-1|Enx1h|KMT6|mKIAA4065 MGI:107940|Ensembl:ENSMUSG00000029687|Vega:OTTMUSG00000021193 6 6 B|6 22.92 cM enhancer of zeste homolog 2 (Drosophila) protein-coding enhancer of zeste homolog 2 (Drosophila) mmu-miR-101a predicted by miR-101 (Homo sapiens), and Ezh2 predicted by EZH2 (Homo sapiens) according to Pubmed ID (24211739) 4366 mmu-miR-721 miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0003515 miRNA Atg2b autophagy down Mus musculus prediction 10090 76559 2410024A21Rik|AI047755|AI503411|AW558123|C030004M05Rik|C630028L02Rik|mKIAA4067 MGI:1923809|Ensembl:ENSMUSG00000041341 12 12 E|12 autophagy related 2B protein-coding autophagy related 2B mmu-miR-721 predicted by miR-130a (Homo sapiens), and Atg2b predicted by ATG2B (Homo sapiens) according to Pubmed ID (22902544) 4367 mmu-miR-295 miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0000373 miRNA Fyco1 autophagy down Mus musculus prediction 10090 17281 2810409M01Rik|Mem2|RUFY3|ZFYVE7 MGI:107277|Ensembl:ENSMUSG00000025241|Vega:OTTMUSG00000044623 9 9 F|9 74.52 cM FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 mmu-miR-295 predicted by miR-373 (Homo sapiens), and Fyco1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 4368 mmu-let-7b let-7/98/4458/4500 MIMAT0000522 miRNA Olr1 autophagy down Mus musculus prediction 10090 108078 LOX-1|SR-EI|Scare1 MGI:1261434|Ensembl:ENSMUSG00000030162|Vega:OTTMUSG00000034583 6 6 F3|6 oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding oxidized low density lipoprotein (lectin-like) receptor 1 mmu-let-7b predicted by let-7g (Mus musculus), and Olr1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 4369 mmu-miR-15b miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000124 miRNA Atg14 autophagy down Mus musculus prediction 10090 100504663 4832427M01|Atg14L|D14Ertd114e|D14Ertd436e MGI:1261775|Ensembl:ENSMUSG00000037526 14 14 C1|14 24.6 cM autophagy related 14 protein-coding autophagy related 14 mmu-miR-15b predicted by miR-195 (Homo sapiens), and Atg14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 4370 mmu-miR-30d miR-30abcdef/30abe-5p/384-5p MIMAT0000515 miRNA Atg12 autophagy down Mus musculus prediction 10090 67526 4931423H11Rik|A330058M13Rik|Apg12l|Atg12l MGI:1914776|Ensembl:ENSMUSG00000032905 18 18 C|18 autophagy related 12 protein-coding autophagy related 12 mmu-miR-30d predicted by miR-30b (Homo sapiens), and Atg12 predicted by ATG12 (Homo sapiens) according to Pubmed ID (22647547),(23274497) 4371 mmu-miR-294 miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0000372 miRNA Fyco1 autophagy down Mus musculus prediction 10090 17281 2810409M01Rik|Mem2|RUFY3|ZFYVE7 MGI:107277|Ensembl:ENSMUSG00000025241|Vega:OTTMUSG00000044623 9 9 F|9 74.52 cM FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 mmu-miR-294 predicted by miR-373 (Homo sapiens), and Fyco1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 4372 mmu-let-7a let-7/98/4458/4500 MIMAT0000521 miRNA Olr1 autophagy down Mus musculus prediction 10090 108078 LOX-1|SR-EI|Scare1 MGI:1261434|Ensembl:ENSMUSG00000030162|Vega:OTTMUSG00000034583 6 6 F3|6 oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding oxidized low density lipoprotein (lectin-like) receptor 1 mmu-let-7a predicted by let-7g (Mus musculus), and Olr1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 4373 mmu-miR-130b miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0000387 miRNA Rb1cc1 autophagy down Mus musculus prediction 10090 12421 2900055E04Rik|5930404L04Rik|Cc1|FIP200|LaXp180 MGI:1341850|Ensembl:ENSMUSG00000025907|Vega:OTTMUSG00000033467 1 1|1 A2 RB1-inducible coiled-coil 1 protein-coding RB1-inducible coiled-coil 1 mmu-miR-130b predicted by miR-133b (Homo sapiens), and Rb1cc1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 4374 mmu-miR-17 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000649 miRNA Fyco1 autophagy down Mus musculus prediction 10090 17281 2810409M01Rik|Mem2|RUFY3|ZFYVE7 MGI:107277|Ensembl:ENSMUSG00000025241|Vega:OTTMUSG00000044623 9 9 F|9 74.52 cM FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 mmu-miR-17 predicted by miR-93 (Homo sapiens), and Fyco1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 4375 mmu-miR-291a-3p miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0000368 miRNA Fyco1 autophagy down Mus musculus prediction 10090 17281 2810409M01Rik|Mem2|RUFY3|ZFYVE7 MGI:107277|Ensembl:ENSMUSG00000025241|Vega:OTTMUSG00000044623 9 9 F|9 74.52 cM FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 mmu-miR-291a-3p predicted by miR-373 (Homo sapiens), and Fyco1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 4376 mmu-miR-25 miR-25/32/92abc/363/363-3p/367 MIMAT0000652 miRNA Ulk1 autophagy down Mus musculus prediction 10090 22241 AU041434|Unc51.1|mKIAA0722 MGI:1270126|Ensembl:ENSMUSG00000029512 5 5|5 F unc-51 like kinase 1 protein-coding unc-51 like kinase 1 mmu-miR-25 predicted by miR-25 (Homo sapiens), and Ulk1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (25026296) 4377 mmu-miR-1907 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0007876 miRNA Bcl2l2 autophagy down Mus musculus prediction 10090 12050 AW048834|Bcl-w|Gtrgal2|Gtrosa41|bclw|c98 MGI:108052|Ensembl:ENSMUSG00000089682|Vega:OTTMUSG00000032812 14 14 C3|14 27.98 cM BCL2-like 2 protein-coding BCL2-like 2 mmu-miR-1907 predicted by miR-15b (Mus musculus), and Bcl2l2 predicted by Bcl2l2 (Mus musculus) according to Pubmed ID (21770019) 4378 mmu-miR-29c miR-29abcd MIMAT0000536 miRNA Psme4 autophagy down Mus musculus prediction 10090 103554 AA409398|AU041366|TEMO|mKIAA0077 MGI:2143994|Ensembl:ENSMUSG00000040850|Vega:OTTMUSG00000005356 11 11 A4|11 proteasome (prosome, macropain) activator subunit 4 protein-coding proteasome (prosome, macropain) activator subunit 4 mmu-miR-29c predicted by miR-29b (Homo sapiens), and Psme4 predicted by PSME4 (Homo sapiens) according to Pubmed ID (25234165) 4379 mmu-miR-98 let-7/98/4458/4500 MIMAT0000545 miRNA Atg4b autophagy down Mus musculus prediction 10090 66615 2510009N07Rik|AW048066|Apg4b|Atg4bl|Autl1 MGI:1913865|Ensembl:ENSMUSG00000026280|Vega:OTTMUSG00000032629 1 1 D|1 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase mmu-miR-98 predicted by let-7b (Homo sapiens), and Atg4b predicted by ATG4B (Homo sapiens) according to Pubmed ID (22135297) 4380 mmu-let-7d let-7/98/4458/4500 MIMAT0000383 miRNA Olr1 autophagy down Mus musculus prediction 10090 108078 LOX-1|SR-EI|Scare1 MGI:1261434|Ensembl:ENSMUSG00000030162|Vega:OTTMUSG00000034583 6 6 F3|6 oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding oxidized low density lipoprotein (lectin-like) receptor 1 mmu-let-7d predicted by let-7g (Mus musculus), and Olr1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 4381 mmu-miR-29c miR-29abcd MIMAT0000536 miRNA Atg9a autophagy down Mus musculus prediction 10090 245860 AU019532|Apg9l1|Atg9|Atg9l1 MGI:2138446|Ensembl:ENSMUSG00000033124 1 1 C3|1 autophagy related 9A protein-coding autophagy related 9A mmu-miR-29c predicted by miR-29b (Bos taurus), and Atg9a predicted by ATG9A (Bos taurus) according to Pubmed ID (25234643) 4382 mmu-miR-30a miR-30abcdef/30abe-5p/384-5p MIMAT0000128 miRNA Bnip3l autophagy down Mus musculus prediction 10090 12177 C86132|D14Ertd719e|Nip3L|Nix MGI:1332659|Ensembl:ENSMUSG00000022051|Vega:OTTMUSG00000023686 14 14 D1|14 34.6 cM BCL2/adenovirus E1B interacting protein 3-like protein-coding BCL2/adenovirus E1B interacting protein 3-like mmu-miR-30a predicted by miR-30d (Homo sapiens), and Bnip3l predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 4383 mmu-miR-1961 let-7/98/4458/4500 MIMAT0009434 miRNA Mtor autophagy down Mus musculus prediction 10090 56717 2610315D21Rik|AI327068|FRAP|FRAP2|Frap1|RAFT1|RAPT1|flat MGI:1928394|Ensembl:ENSMUSG00000028991|Vega:OTTMUSG00000010950 4 4 E1|4 78.76 cM mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) mmu-miR-1961 predicted by let-7 (Homo sapiens), and Mtor predicted by MTOR (Homo sapiens) according to Pubmed ID (25295787) 4384 mmu-miR-17 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000649 miRNA Hif1a autophagy down Mus musculus prediction 10090 15251 AA959795|HIF1alpha|MOP1|bHLHe78 MGI:106918|Ensembl:ENSMUSG00000021109|Vega:OTTMUSG00000019740 12 12 C3|12 31.99 cM hypoxia inducible factor 1, alpha subunit protein-coding hypoxia inducible factor 1, alpha subunit mmu-miR-17 predicted by miR-20a (Homo sapiens), and Hif1a predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 4385 mmu-miR-144 miR-144 MIMAT0000156 miRNA Atg4a autophagy down Mus musculus prediction 10090 666468 AI627006|AV169859|Apg4a|Atg4al|Autl2 MGI:2147903|Ensembl:ENSMUSG00000079418|Vega:OTTMUSG00000018921 X X F1|X autophagy related 4A, cysteine peptidase protein-coding autophagy related 4A, cysteine peptidase mmu-miR-144 predicted by miR-144 (Homo sapiens), and Atg4a predicted by ATG4A (Homo sapiens) according to Pubmed ID (25652854) 4386 mmu-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003187 miRNA Hif1a autophagy down Mus musculus prediction 10090 15251 AA959795|HIF1alpha|MOP1|bHLHe78 MGI:106918|Ensembl:ENSMUSG00000021109|Vega:OTTMUSG00000019740 12 12 C3|12 31.99 cM hypoxia inducible factor 1, alpha subunit protein-coding hypoxia inducible factor 1, alpha subunit mmu-miR-20b predicted by miR-20a (Homo sapiens), and Hif1a predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 4387 mmu-miR-721 miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0003515 miRNA Rb1cc1 autophagy down Mus musculus prediction 10090 12421 2900055E04Rik|5930404L04Rik|Cc1|FIP200|LaXp180 MGI:1341850|Ensembl:ENSMUSG00000025907|Vega:OTTMUSG00000033467 1 1|1 A2 RB1-inducible coiled-coil 1 protein-coding RB1-inducible coiled-coil 1 mmu-miR-721 predicted by miR-133b (Homo sapiens), and Rb1cc1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 4388 mmu-miR-295 miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0000373 miRNA Ulk1 autophagy down Mus musculus prediction 10090 22241 AU041434|Unc51.1|mKIAA0722 MGI:1270126|Ensembl:ENSMUSG00000029512 5 5|5 F unc-51 like kinase 1 protein-coding unc-51 like kinase 1 mmu-miR-295 predicted by miR-291 (Mus musculus), and Ulk1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 4389 mmu-miR-17 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000649 miRNA Atg7 autophagy down Mus musculus prediction 10090 74244 1810013K23Rik|Agp7|Apg7l|Atg7l|Gm21553 MGI:1921494|Ensembl:ENSMUSG00000030314|Vega:OTTMUSG00000043567 6 6 E3|6 autophagy related 7 protein-coding autophagy related 7 mmu-miR-17 predicted by miR-17 (Homo sapiens), and Atg7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 4390 mmu-miR-143 miR-143/1721/4770 MIMAT0000247 miRNA Atg2b autophagy down Mus musculus prediction 10090 76559 2410024A21Rik|AI047755|AI503411|AW558123|C030004M05Rik|C630028L02Rik|mKIAA4067 MGI:1923809|Ensembl:ENSMUSG00000041341 12 12 E|12 autophagy related 2B protein-coding autophagy related 2B mmu-miR-143 predicted by miR-143 (Homo sapiens), and Atg2b predicted by ATG2B (Homo sapiens) according to Pubmed ID (25322940) 4391 mmu-miR-30b miR-30abcdef/30abe-5p/384-5p MIMAT0000130 miRNA Becn1 autophagy down Mus musculus prediction 10090 56208 4921513J16Rik|5430417M23Rik|Atg6 MGI:1891828 11 11 D|11 beclin 1, autophagy related protein-coding beclin 1, autophagy related mmu-miR-30b predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and Becn1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 4392 mmu-miR-199a-5p miR-199ab-5p MIMAT0000229 miRNA Dram1 autophagy down Mus musculus prediction 10090 71712 1200002N14Rik|Dram MGI:1918962|Ensembl:ENSMUSG00000020057|Vega:OTTMUSG00000023972 10 10 C1|10 DNA-damage regulated autophagy modulator 1 protein-coding DNA-damage regulated autophagy modulator 1 mmu-miR-199a-5p predicted by miR-199a-5p (Homo sapiens), and Dram1 predicted by DRAM1 (Homo sapiens) according to Pubmed ID (23337876) 4393 mmu-miR-16 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000527 miRNA Atg14 autophagy down Mus musculus prediction 10090 100504663 4832427M01|Atg14L|D14Ertd114e|D14Ertd436e MGI:1261775|Ensembl:ENSMUSG00000037526 14 14 C1|14 24.6 cM autophagy related 14 protein-coding autophagy related 14 mmu-miR-16 predicted by miR-195 (Homo sapiens), and Atg14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 4394 mmu-miR-144 miR-144 MIMAT0000156 miRNA Gsk3b autophagy down Mus musculus prediction 10090 56637 7330414F15Rik|8430431H08Rik|C86142|GSK-3|GSK-3beta|GSK3 MGI:1861437|Ensembl:ENSMUSG00000022812|Vega:OTTMUSG00000016276 16 16|16 B4 glycogen synthase kinase 3 beta protein-coding glycogen synthase kinase 3 beta mmu-miR-144 predicted by miR-144 (Homo sapiens), and Gsk3b predicted by GSK3B (Homo sapiens) according to Pubmed ID (25060662) 4395 mmu-miR-93 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000540 miRNA Fyco1 autophagy down Mus musculus prediction 10090 17281 2810409M01Rik|Mem2|RUFY3|ZFYVE7 MGI:107277|Ensembl:ENSMUSG00000025241|Vega:OTTMUSG00000044623 9 9 F|9 74.52 cM FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 mmu-miR-93 predicted by miR-93 (Homo sapiens), and Fyco1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 4396 mmu-miR-320 miR-320abcd/4429 MIMAT0000666 miRNA Ulk1 autophagy down Mus musculus prediction 10090 22241 AU041434|Unc51.1|mKIAA0722 MGI:1270126|Ensembl:ENSMUSG00000029512 5 5|5 F unc-51 like kinase 1 protein-coding unc-51 like kinase 1 mmu-miR-320 predicted by miR-320a (Homo sapiens), and Ulk1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (23622248) 4397 mmu-miR-1907 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0007876 miRNA Bag5 autophagy down Mus musculus prediction 10090 70369 1600025G07Rik|4930405J06Rik MGI:1917619|Ensembl:ENSMUSG00000049792|Vega:OTTMUSG00000028789 12 12 F2|12 BCL2-associated athanogene 5 protein-coding BCL2-associated athanogene 5 mmu-miR-1907 predicted by miR-16 (Mus musculus), and Bag5 predicted by Bag5 (Mus musculus) according to Pubmed ID (21770019) 4398 mmu-let-7a let-7/98/4458/4500 MIMAT0000521 miRNA Igf1r autophagy down Mus musculus prediction 10090 16001 A330103N21Rik|CD221|D930020L01|IGF-1R|hyft MGI:96433 7 7 D1|7 37.27 cM insulin-like growth factor I receptor protein-coding insulin-like growth factor I receptor mmu-let-7a predicted by let-7i (Homo sapiens), and Igf1r predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 4399 mmu-miR-302a miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0000380 miRNA Atg7 autophagy down Mus musculus prediction 10090 74244 1810013K23Rik|Agp7|Apg7l|Atg7l|Gm21553 MGI:1921494|Ensembl:ENSMUSG00000030314|Vega:OTTMUSG00000043567 6 6 E3|6 autophagy related 7 protein-coding autophagy related 7 mmu-miR-302a predicted by miR-291 (Mus musculus), and Atg7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 4400 mmu-let-7i let-7/98/4458/4500 MIMAT0000122 miRNA Igf1r autophagy down Mus musculus prediction 10090 16001 A330103N21Rik|CD221|D930020L01|IGF-1R|hyft MGI:96433 7 7 D1|7 37.27 cM insulin-like growth factor I receptor protein-coding insulin-like growth factor I receptor mmu-let-7i predicted by let-7i (Homo sapiens), and Igf1r predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 4401 mmu-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000386 miRNA Atg16l1 autophagy down Mus musculus prediction 10090 77040 1500009K01Rik|Apg16l|Atg16l|WDR30 MGI:1924290|Ensembl:ENSMUSG00000026289|Vega:OTTMUSG00000016467 1 1 D|1 autophagy related 16-like 1 (S. cerevisiae) protein-coding autophagy related 16-like 1 (S. cerevisiae) mmu-miR-106b predicted by miR-106b (Homo sapiens), and Atg16l1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 4402 mmu-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000529 miRNA Ulk1 autophagy down Mus musculus prediction 10090 22241 AU041434|Unc51.1|mKIAA0722 MGI:1270126|Ensembl:ENSMUSG00000029512 5 5|5 F unc-51 like kinase 1 protein-coding unc-51 like kinase 1 mmu-miR-20a predicted by miR-106b (Homo sapiens), and Ulk1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 4403 mmu-miR-295 miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0000373 miRNA Atg7 autophagy down Mus musculus prediction 10090 74244 1810013K23Rik|Agp7|Apg7l|Atg7l|Gm21553 MGI:1921494|Ensembl:ENSMUSG00000030314|Vega:OTTMUSG00000043567 6 6 E3|6 autophagy related 7 protein-coding autophagy related 7 mmu-miR-295 predicted by miR-291 (Mus musculus), and Atg7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 4404 mmu-miR-376b miR-376abd/376b-3p MIMAT0001092 miRNA Atg4c autophagy down Mus musculus prediction 10090 242557 Apg4-C|Apg4c|Atg4cl|Autl1 MGI:2651854|Ensembl:ENSMUSG00000028550|Vega:OTTMUSG00000007980 4 4 C6|4 autophagy related 4C, cysteine peptidase protein-coding autophagy related 4C, cysteine peptidase mmu-miR-376b predicted by miR-376b (Homo sapiens), and Atg4c predicted by ATG4C (Homo sapiens) according to Pubmed ID (22248718),(22902544),(24358205) 4405 mmu-miR-1961 let-7/98/4458/4500 MIMAT0009434 miRNA Atg4b autophagy down Mus musculus prediction 10090 66615 2510009N07Rik|AW048066|Apg4b|Atg4bl|Autl1 MGI:1913865|Ensembl:ENSMUSG00000026280|Vega:OTTMUSG00000032629 1 1 D|1 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase mmu-miR-1961 predicted by let-7b (Homo sapiens), and Atg4b predicted by ATG4B (Homo sapiens) according to Pubmed ID (22135297) 4406 mmu-miR-29b miR-29abcd MIMAT0000127 miRNA Atg9a autophagy down Mus musculus prediction 10090 245860 AU019532|Apg9l1|Atg9|Atg9l1 MGI:2138446|Ensembl:ENSMUSG00000033124 1 1 C3|1 autophagy related 9A protein-coding autophagy related 9A mmu-miR-29b predicted by miR-29b (Bos taurus), and Atg9a predicted by ATG9A (Bos taurus) according to Pubmed ID (25234643) 4407 mmu-let-7f let-7/98/4458/4500 MIMAT0000525 miRNA Mtor autophagy down Mus musculus prediction 10090 56717 2610315D21Rik|AI327068|FRAP|FRAP2|Frap1|RAFT1|RAPT1|flat MGI:1928394|Ensembl:ENSMUSG00000028991|Vega:OTTMUSG00000010950 4 4 E1|4 78.76 cM mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) mmu-let-7f predicted by let-7 (Homo sapiens), and Mtor predicted by MTOR (Homo sapiens) according to Pubmed ID (25295787) 4408 mmu-miR-30b miR-30abcdef/30abe-5p/384-5p MIMAT0000130 miRNA Bnip3l autophagy down Mus musculus prediction 10090 12177 C86132|D14Ertd719e|Nip3L|Nix MGI:1332659|Ensembl:ENSMUSG00000022051|Vega:OTTMUSG00000023686 14 14 D1|14 34.6 cM BCL2/adenovirus E1B interacting protein 3-like protein-coding BCL2/adenovirus E1B interacting protein 3-like mmu-miR-30b predicted by miR-30d (Homo sapiens), and Bnip3l predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 4409 mmu-miR-17 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000649 miRNA Sqstm1 autophagy down Mus musculus prediction 10090 18412 A170|OSF-6|Osi|STAP|STONE14|p62 MGI:107931|Ensembl:ENSMUSG00000015837|Vega:OTTMUSG00000005574 11 11|11 B1.2 sequestosome 1 protein-coding sequestosome 1 mmu-miR-17 predicted by miR-106b (Homo sapiens),miR-106 (Mus musculus), and Sqstm1 predicted by Sqstm1 (Mus musculus),SQSTM1 (Homo sapiens) according to Pubmed ID (21628417),(22441107),(25485521),(25617127) 4410 mmu-miR-130a miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0000141 miRNA Atg2b autophagy down Mus musculus prediction 10090 76559 2410024A21Rik|AI047755|AI503411|AW558123|C030004M05Rik|C630028L02Rik|mKIAA4067 MGI:1923809|Ensembl:ENSMUSG00000041341 12 12 E|12 autophagy related 2B protein-coding autophagy related 2B mmu-miR-130a predicted by miR-130a (Homo sapiens), and Atg2b predicted by ATG2B (Homo sapiens) according to Pubmed ID (22902544) 4411 mmu-let-7g let-7/98/4458/4500 MIMAT0000121 miRNA Igf1r autophagy down Mus musculus prediction 10090 16001 A330103N21Rik|CD221|D930020L01|IGF-1R|hyft MGI:96433 7 7 D1|7 37.27 cM insulin-like growth factor I receptor protein-coding insulin-like growth factor I receptor mmu-let-7g predicted by let-7i (Homo sapiens), and Igf1r predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 4412 mmu-miR-30d miR-30abcdef/30abe-5p/384-5p MIMAT0000515 miRNA Atg5 autophagy down Mus musculus prediction 10090 11793 2010107M05Rik|3110067M24Rik|AW319544|Apg5l|Atg5l|C88337|Paddy MGI:1277186|Ensembl:ENSMUSG00000038160 10 10 B2|10 23.24 cM autophagy related 5 protein-coding autophagy related 5 mmu-miR-30d predicted by miR-30a (Homo sapiens), and Atg5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22395361),(22617440),(22902544),(23274497),(24148619) 4413 mmu-miR-30e miR-30abcdef/30abe-5p/384-5p MIMAT0000248 miRNA Atg5 autophagy down Mus musculus prediction 10090 11793 2010107M05Rik|3110067M24Rik|AW319544|Apg5l|Atg5l|C88337|Paddy MGI:1277186|Ensembl:ENSMUSG00000038160 10 10 B2|10 23.24 cM autophagy related 5 protein-coding autophagy related 5 mmu-miR-30e predicted by miR-30a (Homo sapiens), and Atg5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22395361),(22617440),(22902544),(23274497),(24148619) 4414 mmu-miR-98 let-7/98/4458/4500 MIMAT0000545 miRNA Mtor autophagy down Mus musculus prediction 10090 56717 2610315D21Rik|AI327068|FRAP|FRAP2|Frap1|RAFT1|RAPT1|flat MGI:1928394|Ensembl:ENSMUSG00000028991|Vega:OTTMUSG00000010950 4 4 E1|4 78.76 cM mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) mmu-miR-98 predicted by let-7 (Homo sapiens), and Mtor predicted by MTOR (Homo sapiens) according to Pubmed ID (25295787) 4415 mmu-miR-302d miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0003377 miRNA Ulk1 autophagy down Mus musculus prediction 10090 22241 AU041434|Unc51.1|mKIAA0722 MGI:1270126|Ensembl:ENSMUSG00000029512 5 5|5 F unc-51 like kinase 1 protein-coding unc-51 like kinase 1 mmu-miR-302d predicted by miR-291 (Mus musculus), and Ulk1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 4416 mmu-miR-29a miR-29abcd MIMAT0000535 miRNA Psme4 autophagy down Mus musculus prediction 10090 103554 AA409398|AU041366|TEMO|mKIAA0077 MGI:2143994|Ensembl:ENSMUSG00000040850|Vega:OTTMUSG00000005356 11 11 A4|11 proteasome (prosome, macropain) activator subunit 4 protein-coding proteasome (prosome, macropain) activator subunit 4 mmu-miR-29a predicted by miR-29b (Homo sapiens), and Psme4 predicted by PSME4 (Homo sapiens) according to Pubmed ID (25234165) 4417 mmu-miR-29b miR-29abcd MIMAT0000127 miRNA Psme4 autophagy down Mus musculus prediction 10090 103554 AA409398|AU041366|TEMO|mKIAA0077 MGI:2143994|Ensembl:ENSMUSG00000040850|Vega:OTTMUSG00000005356 11 11 A4|11 proteasome (prosome, macropain) activator subunit 4 protein-coding proteasome (prosome, macropain) activator subunit 4 mmu-miR-29b predicted by miR-29b (Homo sapiens), and Psme4 predicted by PSME4 (Homo sapiens) according to Pubmed ID (25234165) 4418 mmu-miR-15a miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000526 miRNA Bag5 autophagy down Mus musculus prediction 10090 70369 1600025G07Rik|4930405J06Rik MGI:1917619|Ensembl:ENSMUSG00000049792|Vega:OTTMUSG00000028789 12 12 F2|12 BCL2-associated athanogene 5 protein-coding BCL2-associated athanogene 5 mmu-miR-15a predicted by miR-16 (Mus musculus), and Bag5 predicted by Bag5 (Mus musculus) according to Pubmed ID (21770019) 4419 mmu-miR-7b miR-7/7ab MIMAT0000678 miRNA Egfr autophagy down Mus musculus prediction 10090 13649 9030024J15Rik|AI552599|Erbb|Errb1|Errp|Wa5|wa-2|wa2 MGI:95294|Ensembl:ENSMUSG00000020122|Vega:OTTMUSG00000005185 11 11 A1-A4|11 9.41 cM epidermal growth factor receptor protein-coding epidermal growth factor receptor mmu-miR-7b predicted by miR-7 (Homo sapiens), and Egfr predicted by EGFR (Homo sapiens) according to Pubmed ID (22492316) 4420 mmu-miR-34c miR-34ac/34bc-5p/449abc/449c-5p MIMAT0000381 miRNA Atg4b autophagy down Mus musculus prediction 10090 66615 2510009N07Rik|AW048066|Apg4b|Atg4bl|Autl1 MGI:1913865|Ensembl:ENSMUSG00000026280|Vega:OTTMUSG00000032629 1 1 D|1 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase mmu-miR-34c predicted by miR-34a (Homo sapiens), and Atg4b predicted by ATG4B (Homo sapiens) according to Pubmed ID (24755409) 4421 mmu-miR-99b miR-99ab/100 MIMAT0000132 miRNA Mtor autophagy down Mus musculus prediction 10090 56717 2610315D21Rik|AI327068|FRAP|FRAP2|Frap1|RAFT1|RAPT1|flat MGI:1928394|Ensembl:ENSMUSG00000028991|Vega:OTTMUSG00000010950 4 4 E1|4 78.76 cM mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) mmu-miR-99b predicted by miR-100 (Homo sapiens), and Mtor predicted by MTOR (Homo sapiens) according to Pubmed ID (25026290) 4422 mmu-let-7d let-7/98/4458/4500 MIMAT0000383 miRNA Mtor autophagy down Mus musculus prediction 10090 56717 2610315D21Rik|AI327068|FRAP|FRAP2|Frap1|RAFT1|RAPT1|flat MGI:1928394|Ensembl:ENSMUSG00000028991|Vega:OTTMUSG00000010950 4 4 E1|4 78.76 cM mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) mmu-let-7d predicted by let-7 (Homo sapiens), and Mtor predicted by MTOR (Homo sapiens) according to Pubmed ID (25295787) 4423 mmu-miR-29a miR-29abcd MIMAT0000535 miRNA Atg9a autophagy down Mus musculus prediction 10090 245860 AU019532|Apg9l1|Atg9|Atg9l1 MGI:2138446|Ensembl:ENSMUSG00000033124 1 1 C3|1 autophagy related 9A protein-coding autophagy related 9A mmu-miR-29a predicted by miR-29b (Bos taurus), and Atg9a predicted by ATG9A (Bos taurus) according to Pubmed ID (25234643) 4424 mmu-miR-181a miR-181abcd/4262 MIMAT0000210 miRNA Atg5 autophagy down Mus musculus prediction 10090 11793 2010107M05Rik|3110067M24Rik|AW319544|Apg5l|Atg5l|C88337|Paddy MGI:1277186|Ensembl:ENSMUSG00000038160 10 10 B2|10 23.24 cM autophagy related 5 protein-coding autophagy related 5 mmu-miR-181a predicted by miR-181a (Homo sapiens), and Atg5 predicted by ATG5 (Homo sapiens) according to Pubmed ID (22356768),(22902544),(23322078) 4425 mmu-miR-20b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003187 miRNA Atg7 autophagy down Mus musculus prediction 10090 74244 1810013K23Rik|Agp7|Apg7l|Atg7l|Gm21553 MGI:1921494|Ensembl:ENSMUSG00000030314|Vega:OTTMUSG00000043567 6 6 E3|6 autophagy related 7 protein-coding autophagy related 7 mmu-miR-20b predicted by miR-17 (Homo sapiens), and Atg7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 4426 mmu-miR-301b miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0004186 miRNA Atg2b autophagy down Mus musculus prediction 10090 76559 2410024A21Rik|AI047755|AI503411|AW558123|C030004M05Rik|C630028L02Rik|mKIAA4067 MGI:1923809|Ensembl:ENSMUSG00000041341 12 12 E|12 autophagy related 2B protein-coding autophagy related 2B mmu-miR-301b predicted by miR-130a (Homo sapiens), and Atg2b predicted by ATG2B (Homo sapiens) according to Pubmed ID (22902544) 4427 rno-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000825 miRNA Fyco1 autophagy down Rattus norvegicus prediction 10116 301085 - RGD:1309069|Ensembl:ENSRNOG00000006336 8 8q32 FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 rno-miR-106b predicted by miR-93 (Homo sapiens), and Fyco1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 4428 rno-miR-30b-5p miR-30abcdef/30abe-5p/384-5p MIMAT0000806 miRNA Becn1 autophagy down Rattus norvegicus prediction 10116 114558 - RGD:620190|Ensembl:ENSRNOG00000020513 10 10q32.1 beclin 1, autophagy related protein-coding beclin 1, autophagy related rno-miR-30b-5p predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and Becn1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 4429 rno-miR-31 miR-31 MIMAT0000810 miRNA Gsk3b autophagy down Rattus norvegicus prediction 10116 84027 - RGD:70982|Ensembl:ENSRNOG00000002833 11 11q21 glycogen synthase kinase 3 beta protein-coding glycogen synthase kinase 3 beta rno-miR-31 predicted by miR-31 (Homo sapiens), and Gsk3b predicted by GSK3B (Homo sapiens) according to Pubmed ID (24343269) 4430 rno-miR-144 miR-144 MIMAT0000850 miRNA Mtor autophagy down Rattus norvegicus prediction 10116 56718 Frap1|RAFT1 RGD:68371|Ensembl:ENSRNOG00000009615 5 5q36 mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) rno-miR-144 predicted by miR-144 (Homo sapiens), and Mtor predicted by MTOR (Homo sapiens) according to Pubmed ID (25060662) 4431 rno-miR-29a miR-29abcd MIMAT0000802 miRNA Psme4 autophagy down Rattus norvegicus prediction 10116 498433 - RGD:1591971|Ensembl:ENSRNOG00000006609 14 14q22 proteasome (prosome, macropain) activator subunit 4 protein-coding proteasome (prosome, macropain) activator subunit 4 rno-miR-29a predicted by miR-29b (Homo sapiens), and Psme4 predicted by PSME4 (Homo sapiens) according to Pubmed ID (25234165) 4432 rno-miR-93 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000817 miRNA Sqstm1 autophagy down Rattus norvegicus prediction 10116 113894 Osi|ZIP|ZIP3 RGD:69287|Ensembl:ENSRNOG00000003147 10 10q21 sequestosome 1 protein-coding sequestosome 1 rno-miR-93 predicted by miR-106b (Homo sapiens),miR-106 (Mus musculus), and Sqstm1 predicted by Sqstm1 (Mus musculus),SQSTM1 (Homo sapiens) according to Pubmed ID (21628417),(22441107),(25485521),(25617127) 4433 rno-miR-101a miR-101/101ab MIMAT0000823 miRNA Ezh2 autophagy down Rattus norvegicus prediction 10116 312299 - RGD:1595860|Ensembl:ENSRNOG00000006048 4 4q24 enhancer of zeste 2 polycomb repressive complex 2 subunit protein-coding enhancer of zeste 2 polycomb repressive complex 2 subunit rno-miR-101a predicted by miR-101 (Homo sapiens), and Ezh2 predicted by EZH2 (Homo sapiens) according to Pubmed ID (24211739) 4434 rno-miR-211 miR-204/204b/211 MIMAT0000882 miRNA Trpm3 autophagy down Rattus norvegicus prediction 10116 309407 - RGD:1304888|Ensembl:ENSRNOG00000027770 1 1q51 transient receptor potential cation channel, subfamily M, member 3 protein-coding transient receptor potential cation channel, subfamily M, member 3 rno-miR-211 predicted by miR-204 (Homo sapiens), and Trpm3 predicted by TRPM3 (Homo sapiens) according to Pubmed ID (25517751) 4435 rno-miR-449a miR-34ac/34bc-5p/449abc/449c-5p MIMAT0001543 miRNA Atg9a autophagy down Rattus norvegicus prediction 10116 363254 RGD1310450 RGD:1310450|Ensembl:ENSRNOG00000018975 9 9q33 autophagy related 9A protein-coding autophagy related 9A rno-miR-449a predicted by miR-34a (Homo sapiens),miR-34a (Rattus norvegicus), and Atg9a predicted by Atg9a (Rattus norvegicus),ATG9A (Homo sapiens) according to Pubmed ID (22902544),(24728149),(24973144) 4436 rno-miR-152 miR-148ab-3p/152 MIMAT0000854 miRNA Atg14 autophagy down Rattus norvegicus prediction 10116 305831 Atg14L|RGD1304610 RGD:1304610|Ensembl:ENSRNOG00000011873 15 15p14 autophagy related 14 protein-coding autophagy related 14 rno-miR-152 predicted by miR-152 (Homo sapiens), and Atg14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (25650716) 4437 rno-miR-449c-5p miR-34ac/34bc-5p/449abc/449c-5p MIMAT0017803 miRNA Atg4b autophagy down Rattus norvegicus prediction 10116 316640 Apg4b RGD:1309664|Ensembl:ENSRNOG00000018403 9 9q36 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase rno-miR-449c-5p predicted by miR-34a (Homo sapiens), and Atg4b predicted by ATG4B (Homo sapiens) according to Pubmed ID (24755409) 4438 rno-miR-497 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0003383 miRNA Bcl2l2 autophagy down Rattus norvegicus prediction 10116 60434 BCL-W|BCL-WEL|BCL-WS|Bclw RGD:620717|Ensembl:ENSRNOG00000015732 15 15p13 Bcl2-like 2 protein-coding Bcl2-like 2 rno-miR-497 predicted by miR-15b (Mus musculus), and Bcl2l2 predicted by Bcl2l2 (Mus musculus) according to Pubmed ID (21770019) 4439 rno-miR-200b miR-200bc/429/548a MIMAT0000875 miRNA Ubqln1 autophagy down Rattus norvegicus prediction 10116 114590 Da41 RGD:620745|Ensembl:ENSRNOG00000019282 17 17p14 ubiquilin 1 protein-coding ubiquilin 1 rno-miR-200b predicted by miR-200c (Homo sapiens), and Ubqln1 predicted by UBQLN1 (Homo sapiens) according to Pubmed ID (25044403) 4440 rno-miR-21 miR-21/590-5p MIMAT0000790 miRNA Bcl2 autophagy down Rattus norvegicus prediction 10116 24224 Bcl-2 RGD:2199|Ensembl:ENSRNOG00000002791 13 13p13 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 rno-miR-21 predicted by miR-21 (Homo sapiens), and Bcl2 predicted by BCL2 (Homo sapiens) according to Pubmed ID (23834154) 4441 rno-let-7b let-7/98/4458/4500 MIMAT0000775 miRNA Atg4b autophagy down Rattus norvegicus prediction 10116 316640 Apg4b RGD:1309664|Ensembl:ENSRNOG00000018403 9 9q36 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase rno-let-7b predicted by let-7b (Homo sapiens), and Atg4b predicted by ATG4B (Homo sapiens) according to Pubmed ID (22135297) 4442 rno-let-7b let-7/98/4458/4500 MIMAT0000775 miRNA Mtor autophagy down Rattus norvegicus prediction 10116 56718 Frap1|RAFT1 RGD:68371|Ensembl:ENSRNOG00000009615 5 5q36 mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) rno-let-7b predicted by let-7 (Homo sapiens), and Mtor predicted by MTOR (Homo sapiens) according to Pubmed ID (25295787) 4443 rno-miR-16 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000785 miRNA Bag5 autophagy down Rattus norvegicus prediction 10116 366734 - RGD:1310847|Ensembl:ENSRNOG00000011527 6 6q32 BCL2-associated athanogene 5 protein-coding BCL2-associated athanogene 5 rno-miR-16 predicted by miR-16 (Mus musculus), and Bag5 predicted by Bag5 (Mus musculus) according to Pubmed ID (21770019) 4444 rno-miR-34a miR-34ac/34bc-5p/449abc/449c-5p MIMAT0000815 miRNA Atg4b autophagy down Rattus norvegicus prediction 10116 316640 Apg4b RGD:1309664|Ensembl:ENSRNOG00000018403 9 9q36 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase rno-miR-34a predicted by miR-34a (Homo sapiens), and Atg4b predicted by ATG4B (Homo sapiens) according to Pubmed ID (24755409) 4445 rno-miR-221 miR-221/222/222ab/1928 MIMAT0000890 miRNA Cdkn1b autophagy down Rattus norvegicus prediction 10116 83571 CDKN4|Cdki1b|Kip1|P27KIP1|p27 RGD:69062|Ensembl:ENSRNOG00000007249 4 4q43 cyclin-dependent kinase inhibitor 1B protein-coding cyclin-dependent kinase inhibitor 1B rno-miR-221 predicted by miR-221 (Homo sapiens), and Cdkn1b predicted by CDKN1B (Homo sapiens) according to Pubmed ID (25394488) 4446 rno-let-7f let-7/98/4458/4500 MIMAT0000778 miRNA Olr1 autophagy down Rattus norvegicus prediction 10116 140914 LOX-1|Oldlr1|Oldr1 RGD:620515|Ensembl:ENSRNOG00000008375 4 4q42 oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding oxidized low density lipoprotein (lectin-like) receptor 1 rno-let-7f predicted by let-7g (Mus musculus), and Olr1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 4447 rno-miR-32 miR-25/32/92abc/363/363-3p/367 MIMAT0000811 miRNA Ulk1 autophagy down Rattus norvegicus prediction 10116 360827 - RGD:1589743|Ensembl:ENSRNOG00000037505 12 12q16 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 rno-miR-32 predicted by miR-25 (Homo sapiens), and Ulk1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (25026296) 4448 rno-miR-30c miR-30abcdef/30abe-5p/384-5p MIMAT0000804 miRNA Becn1 autophagy down Rattus norvegicus prediction 10116 114558 - RGD:620190|Ensembl:ENSRNOG00000020513 10 10q32.1 beclin 1, autophagy related protein-coding beclin 1, autophagy related rno-miR-30c predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and Becn1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 4449 rno-miR-93 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000817 miRNA Ulk1 autophagy down Rattus norvegicus prediction 10116 360827 - RGD:1589743|Ensembl:ENSRNOG00000037505 12 12q16 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 rno-miR-93 predicted by miR-106b (Homo sapiens), and Ulk1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 4450 rno-miR-211 miR-204/204b/211 MIMAT0000882 miRNA Cav1 autophagy down Rattus norvegicus prediction 10116 25404 Cav RGD:2280|Ensembl:ENSRNOG00000006694 4 4q21 caveolin 1, caveolae protein protein-coding caveolin 1, caveolae protein rno-miR-211 predicted by miR-204 (Homo sapiens), and Cav1 predicted by CAV1 (Homo sapiens) according to Pubmed ID (25517751) 4451 rno-miR-183 miR-183 MIMAT0000860 miRNA Map1lc3b autophagy down Rattus norvegicus prediction 10116 64862 Map1lc3|Mpl3|zbs559 RGD:621315|Ensembl:ENSRNOG00000017905 19 19q12 microtubule-associated protein 1 light chain 3 beta protein-coding microtubule-associated protein 1 light chain 3 beta rno-miR-183 predicted by miR-183 (Homo sapiens), and Map1lc3b predicted by MAP1LC3B (Homo sapiens) according to Pubmed ID (21622722) 4452 rno-miR-199a-5p miR-199ab-5p MIMAT0000872 miRNA Becn1 autophagy down Rattus norvegicus prediction 10116 114558 - RGD:620190|Ensembl:ENSRNOG00000020513 10 10q32.1 beclin 1, autophagy related protein-coding beclin 1, autophagy related rno-miR-199a-5p predicted by miR-199a-5p (Homo sapiens), and Becn1 predicted by BECN1 (Homo sapiens) according to Pubmed ID (23337876) 4453 rno-miR-17-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000786 miRNA Atg7 autophagy down Rattus norvegicus prediction 10116 312647 Apg7l RGD:1304817|Ensembl:ENSRNOG00000007486 4 4q42 autophagy related 7 protein-coding autophagy related 7 rno-miR-17-5p predicted by miR-17 (Homo sapiens), and Atg7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 4454 rno-miR-335 miR-335/335-5p MIMAT0000575 miRNA Ulk2 autophagy down Rattus norvegicus prediction 10116 303206 - RGD:1310181|Ensembl:ENSRNOG00000002763 10 10q23 unc-51 like autophagy activating kinase 2 protein-coding unc-51 like autophagy activating kinase 2 rno-miR-335 predicted by miR-335 (Homo sapiens), and Ulk2 predicted by ULK2 (Homo sapiens) according to Pubmed ID (18185580) 4455 rno-miR-92b miR-25/32/92abc/363/363-3p/367 MIMAT0005340 miRNA Ulk1 autophagy down Rattus norvegicus prediction 10116 360827 - RGD:1589743|Ensembl:ENSRNOG00000037505 12 12q16 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 rno-miR-92b predicted by miR-25 (Homo sapiens), and Ulk1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (25026296) 4456 rno-miR-17-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000786 miRNA Sqstm1 autophagy down Rattus norvegicus prediction 10116 113894 Osi|ZIP|ZIP3 RGD:69287|Ensembl:ENSRNOG00000003147 10 10q21 sequestosome 1 protein-coding sequestosome 1 rno-miR-17-5p predicted by miR-106b (Homo sapiens),miR-106 (Mus musculus), and Sqstm1 predicted by Sqstm1 (Mus musculus),SQSTM1 (Homo sapiens) according to Pubmed ID (21628417),(22441107),(25485521),(25617127) 4457 rno-miR-211 miR-204/204b/211 MIMAT0000882 miRNA Map1lc3b autophagy down Rattus norvegicus prediction 10116 64862 Map1lc3|Mpl3|zbs559 RGD:621315|Ensembl:ENSRNOG00000017905 19 19q12 microtubule-associated protein 1 light chain 3 beta protein-coding microtubule-associated protein 1 light chain 3 beta rno-miR-211 predicted by miR-204 (Homo sapiens),miR-204 (Rattus norvegicus), and Map1lc3b predicted by Map1lc3b (Rattus norvegicus),MAP1LC3B (Homo sapiens) according to Pubmed ID (21316776),(21631941),(22516261),(25209181),(25517751) 4458 rno-miR-320 miR-320abcd/4429 MIMAT0000903 miRNA Ulk1 autophagy down Rattus norvegicus prediction 10116 360827 - RGD:1589743|Ensembl:ENSRNOG00000037505 12 12q16 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 rno-miR-320 predicted by miR-320a (Homo sapiens), and Ulk1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (23622248) 4459 rno-miR-130a miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0000836 miRNA Rb1cc1 autophagy down Rattus norvegicus prediction 10116 312927 - RGD:1309346|Ensembl:ENSRNOG00000006833 5 5q12 RB1-inducible coiled-coil 1 protein-coding RB1-inducible coiled-coil 1 rno-miR-130a predicted by miR-133b (Homo sapiens), and Rb1cc1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 4460 rno-miR-30a miR-30abcdef/30abe-5p/384-5p MIMAT0000808 miRNA Bnip3l autophagy down Rattus norvegicus prediction 10116 140923 Nix RGD:621354|Ensembl:ENSRNOG00000009820 15 15p12 BCL2/adenovirus E1B interacting protein 3-like protein-coding BCL2/adenovirus E1B interacting protein 3-like rno-miR-30a predicted by miR-30d (Homo sapiens), and Bnip3l predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 4461 rno-miR-15b miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000784 miRNA Bcl2l2 autophagy down Rattus norvegicus prediction 10116 60434 BCL-W|BCL-WEL|BCL-WS|Bclw RGD:620717|Ensembl:ENSRNOG00000015732 15 15p13 Bcl2-like 2 protein-coding Bcl2-like 2 rno-miR-15b predicted by miR-15b (Mus musculus), and Bcl2l2 predicted by Bcl2l2 (Mus musculus) according to Pubmed ID (21770019) 4462 rno-miR-375 miR-375 MIMAT0005307 miRNA Rb1cc1 autophagy down Rattus norvegicus prediction 10116 312927 - RGD:1309346|Ensembl:ENSRNOG00000006833 5 5q12 RB1-inducible coiled-coil 1 protein-coding RB1-inducible coiled-coil 1 rno-miR-375 predicted by miR-375 (Homo sapiens), and Rb1cc1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (22135297) 4463 rno-miR-34b miR-34ac/34bc-5p/449abc/449c-5p MIMAT0000813 miRNA Atg9a autophagy down Rattus norvegicus prediction 10116 363254 RGD1310450 RGD:1310450|Ensembl:ENSRNOG00000018975 9 9q33 autophagy related 9A protein-coding autophagy related 9A rno-miR-34b predicted by miR-34a (Homo sapiens),miR-34a (Rattus norvegicus), and Atg9a predicted by Atg9a (Rattus norvegicus),ATG9A (Homo sapiens) according to Pubmed ID (22902544),(24728149),(24973144) 4464 rno-miR-293 miR-290-5p/292-5p/371-5p/293 MIMAT0012847 miRNA Ulk1 autophagy down Rattus norvegicus prediction 10116 360827 - RGD:1589743|Ensembl:ENSRNOG00000037505 12 12q16 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 rno-miR-293 predicted by miR-290 (Mus musculus), and Ulk1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 4465 rno-miR-205 miR-205/205ab MIMAT0000878 miRNA Rab27a autophagy down Rattus norvegicus prediction 10116 50645 ram RGD:620918|Ensembl:ENSRNOG00000007533 8 8q24 RAB27A, member RAS oncogene family protein-coding RAB27A, member RAS oncogene family rno-miR-205 predicted by miR-205 (Homo sapiens), and Rab27a predicted by RAB27A (Homo sapiens) according to Pubmed ID (24370341) 4466 rno-miR-363 miR-25/32/92abc/363/363-3p/367 MIMAT0003210 miRNA Ulk1 autophagy down Rattus norvegicus prediction 10116 360827 - RGD:1589743|Ensembl:ENSRNOG00000037505 12 12q16 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 rno-miR-363 predicted by miR-25 (Homo sapiens), and Ulk1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (25026296) 4467 rno-miR-291a-3p miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0000895 miRNA Fyco1 autophagy down Rattus norvegicus prediction 10116 301085 - RGD:1309069|Ensembl:ENSRNOG00000006336 8 8q32 FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 rno-miR-291a-3p predicted by miR-373 (Homo sapiens), and Fyco1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 4468 rno-miR-29c miR-29abcd MIMAT0000803 miRNA Atg9a autophagy down Rattus norvegicus prediction 10116 363254 RGD1310450 RGD:1310450|Ensembl:ENSRNOG00000018975 9 9q33 autophagy related 9A protein-coding autophagy related 9A rno-miR-29c predicted by miR-29b (Bos taurus), and Atg9a predicted by ATG9A (Bos taurus) according to Pubmed ID (25234643) 4469 rno-miR-30d miR-30abcdef/30abe-5p/384-5p MIMAT0000807 miRNA Becn1 autophagy down Rattus norvegicus prediction 10116 114558 - RGD:620190|Ensembl:ENSRNOG00000020513 10 10q32.1 beclin 1, autophagy related protein-coding beclin 1, autophagy related rno-miR-30d predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and Becn1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 4470 rno-miR-30e miR-30abcdef/30abe-5p/384-5p MIMAT0000805 miRNA Becn1 autophagy down Rattus norvegicus prediction 10116 114558 - RGD:620190|Ensembl:ENSRNOG00000020513 10 10q32.1 beclin 1, autophagy related protein-coding beclin 1, autophagy related rno-miR-30e predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and Becn1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 4471 rno-miR-30d miR-30abcdef/30abe-5p/384-5p MIMAT0000807 miRNA Bnip3l autophagy down Rattus norvegicus prediction 10116 140923 Nix RGD:621354|Ensembl:ENSRNOG00000009820 15 15p12 BCL2/adenovirus E1B interacting protein 3-like protein-coding BCL2/adenovirus E1B interacting protein 3-like rno-miR-30d predicted by miR-30d (Homo sapiens), and Bnip3l predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 4472 rno-miR-497 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0003383 miRNA Atg14 autophagy down Rattus norvegicus prediction 10116 305831 Atg14L|RGD1304610 RGD:1304610|Ensembl:ENSRNOG00000011873 15 15p14 autophagy related 14 protein-coding autophagy related 14 rno-miR-497 predicted by miR-195 (Homo sapiens), and Atg14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 4473 rno-let-7c let-7/98/4458/4500 MIMAT0000776 miRNA Olr1 autophagy down Rattus norvegicus prediction 10116 140914 LOX-1|Oldlr1|Oldr1 RGD:620515|Ensembl:ENSRNOG00000008375 4 4q42 oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding oxidized low density lipoprotein (lectin-like) receptor 1 rno-let-7c predicted by let-7g (Mus musculus), and Olr1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 4474 rno-miR-105 miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0012825 miRNA Fyco1 autophagy down Rattus norvegicus prediction 10116 301085 - RGD:1309069|Ensembl:ENSRNOG00000006336 8 8q32 FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 rno-miR-105 predicted by miR-373 (Homo sapiens), and Fyco1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 4475 rno-miR-322 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0001619 miRNA Atg14 autophagy down Rattus norvegicus prediction 10116 305831 Atg14L|RGD1304610 RGD:1304610|Ensembl:ENSRNOG00000011873 15 15p14 autophagy related 14 protein-coding autophagy related 14 rno-miR-322 predicted by miR-195 (Homo sapiens), and Atg14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 4476 rno-miR-204 miR-204/204b/211 MIMAT0000877 miRNA Trpm3 autophagy down Rattus norvegicus prediction 10116 309407 - RGD:1304888|Ensembl:ENSRNOG00000027770 1 1q51 transient receptor potential cation channel, subfamily M, member 3 protein-coding transient receptor potential cation channel, subfamily M, member 3 rno-miR-204 predicted by miR-204 (Homo sapiens), and Trpm3 predicted by TRPM3 (Homo sapiens) according to Pubmed ID (25517751) 4477 rno-miR-16 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000785 miRNA Atg14 autophagy down Rattus norvegicus prediction 10116 305831 Atg14L|RGD1304610 RGD:1304610|Ensembl:ENSRNOG00000011873 15 15p14 autophagy related 14 protein-coding autophagy related 14 rno-miR-16 predicted by miR-195 (Homo sapiens), and Atg14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 4478 rno-miR-30b-5p miR-30abcdef/30abe-5p/384-5p MIMAT0000806 miRNA Bnip3l autophagy down Rattus norvegicus prediction 10116 140923 Nix RGD:621354|Ensembl:ENSRNOG00000009820 15 15p12 BCL2/adenovirus E1B interacting protein 3-like protein-coding BCL2/adenovirus E1B interacting protein 3-like rno-miR-30b-5p predicted by miR-30d (Homo sapiens), and Bnip3l predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 4479 rno-miR-17-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000786 miRNA Ulk1 autophagy down Rattus norvegicus prediction 10116 360827 - RGD:1589743|Ensembl:ENSRNOG00000037505 12 12q16 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 rno-miR-17-5p predicted by miR-106b (Homo sapiens), and Ulk1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 4480 rno-miR-34b miR-34ac/34bc-5p/449abc/449c-5p MIMAT0000813 miRNA Atg4b autophagy down Rattus norvegicus prediction 10116 316640 Apg4b RGD:1309664|Ensembl:ENSRNOG00000018403 9 9q36 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase rno-miR-34b predicted by miR-34a (Homo sapiens), and Atg4b predicted by ATG4B (Homo sapiens) according to Pubmed ID (24755409) 4481 rno-miR-105 miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0012825 miRNA Atg7 autophagy down Rattus norvegicus prediction 10116 312647 Apg7l RGD:1304817|Ensembl:ENSRNOG00000007486 4 4q42 autophagy related 7 protein-coding autophagy related 7 rno-miR-105 predicted by miR-291 (Mus musculus), and Atg7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 4482 rno-miR-30b-5p miR-30abcdef/30abe-5p/384-5p MIMAT0000806 miRNA Atg12 autophagy down Rattus norvegicus prediction 10116 361321 Apg12l RGD:1306306|Ensembl:ENSRNOG00000000157 18 18q11 autophagy related 12 protein-coding autophagy related 12 rno-miR-30b-5p predicted by miR-30b (Homo sapiens), and Atg12 predicted by ATG12 (Homo sapiens) according to Pubmed ID (22647547),(23274497) 4483 rno-miR-99b miR-99ab/100 MIMAT0000821 miRNA Igf1r autophagy down Rattus norvegicus prediction 10116 25718 IGFIRC|JTK13 RGD:2869|Ensembl:ENSRNOG00000014187 1 1q22 insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor rno-miR-99b predicted by miR-100 (Homo sapiens), and Igf1r predicted by IGF1R (Homo sapiens) according to Pubmed ID (25026290) 4484 rno-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000602 miRNA Atg7 autophagy down Rattus norvegicus prediction 10116 312647 Apg7l RGD:1304817|Ensembl:ENSRNOG00000007486 4 4q42 autophagy related 7 protein-coding autophagy related 7 rno-miR-20a predicted by miR-17 (Homo sapiens), and Atg7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 4485 rno-miR-93 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000817 miRNA Hif1a autophagy down Rattus norvegicus prediction 10116 29560 MOP1 RGD:61928|Ensembl:ENSRNOG00000008292 6 6q24 hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) rno-miR-93 predicted by miR-20a (Homo sapiens), and Hif1a predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 4486 rno-miR-20b-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003211 miRNA Ulk1 autophagy down Rattus norvegicus prediction 10116 360827 - RGD:1589743|Ensembl:ENSRNOG00000037505 12 12q16 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 rno-miR-20b-5p predicted by miR-106b (Homo sapiens), and Ulk1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 4487 rno-miR-100 miR-99ab/100 MIMAT0000822 miRNA Igf1r autophagy down Rattus norvegicus prediction 10116 25718 IGFIRC|JTK13 RGD:2869|Ensembl:ENSRNOG00000014187 1 1q22 insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor rno-miR-100 predicted by miR-100 (Homo sapiens), and Igf1r predicted by IGF1R (Homo sapiens) according to Pubmed ID (25026290) 4488 rno-let-7d let-7/98/4458/4500 MIMAT0000562 miRNA Mtor autophagy down Rattus norvegicus prediction 10116 56718 Frap1|RAFT1 RGD:68371|Ensembl:ENSRNOG00000009615 5 5q36 mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) rno-let-7d predicted by let-7 (Homo sapiens), and Mtor predicted by MTOR (Homo sapiens) according to Pubmed ID (25295787) 4489 rno-miR-449c-5p miR-34ac/34bc-5p/449abc/449c-5p MIMAT0017803 miRNA Atg9a autophagy down Rattus norvegicus prediction 10116 363254 RGD1310450 RGD:1310450|Ensembl:ENSRNOG00000018975 9 9q33 autophagy related 9A protein-coding autophagy related 9A rno-miR-449c-5p predicted by miR-34a (Homo sapiens),miR-34a (Rattus norvegicus), and Atg9a predicted by Atg9a (Rattus norvegicus),ATG9A (Homo sapiens) according to Pubmed ID (22902544),(24728149),(24973144) 4490 rno-miR-29c miR-29abcd MIMAT0000803 miRNA Psme4 autophagy down Rattus norvegicus prediction 10116 498433 - RGD:1591971|Ensembl:ENSRNOG00000006609 14 14q22 proteasome (prosome, macropain) activator subunit 4 protein-coding proteasome (prosome, macropain) activator subunit 4 rno-miR-29c predicted by miR-29b (Homo sapiens), and Psme4 predicted by PSME4 (Homo sapiens) according to Pubmed ID (25234165) 4491 rno-miR-98 let-7/98/4458/4500 MIMAT0000819 miRNA Olr1 autophagy down Rattus norvegicus prediction 10116 140914 LOX-1|Oldlr1|Oldr1 RGD:620515|Ensembl:ENSRNOG00000008375 4 4q42 oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding oxidized low density lipoprotein (lectin-like) receptor 1 rno-miR-98 predicted by let-7g (Mus musculus), and Olr1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 4492 rno-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000825 miRNA Atg7 autophagy down Rattus norvegicus prediction 10116 312647 Apg7l RGD:1304817|Ensembl:ENSRNOG00000007486 4 4q42 autophagy related 7 protein-coding autophagy related 7 rno-miR-106b predicted by miR-17 (Homo sapiens), and Atg7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 4493 rno-miR-301b miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0005304 miRNA Rb1cc1 autophagy down Rattus norvegicus prediction 10116 312927 - RGD:1309346|Ensembl:ENSRNOG00000006833 5 5q12 RB1-inducible coiled-coil 1 protein-coding RB1-inducible coiled-coil 1 rno-miR-301b predicted by miR-133b (Homo sapiens), and Rb1cc1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 4494 rno-miR-16 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000785 miRNA Atg7 autophagy down Rattus norvegicus prediction 10116 312647 Apg7l RGD:1304817|Ensembl:ENSRNOG00000007486 4 4q42 autophagy related 7 protein-coding autophagy related 7 rno-miR-16 predicted by miR-16 (Homo sapiens), and Atg7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23143396) 4495 rno-miR-31 miR-31 MIMAT0000810 miRNA Ppp2r4 autophagy down Rattus norvegicus prediction 10116 362102 - RGD:1308354|Ensembl:ENSRNOG00000018457 3 3p12 protein phosphatase 2A activator, regulatory subunit 4 protein-coding protein phosphatase 2A activator, regulatory subunit 4 rno-miR-31 predicted by miR-31 (Homo sapiens), and Ppp2r4 predicted by PPP2R4 (Homo sapiens) according to Pubmed ID (24343269) 4496 rno-miR-20b-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003211 miRNA Hif1a autophagy down Rattus norvegicus prediction 10116 29560 MOP1 RGD:61928|Ensembl:ENSRNOG00000008292 6 6q24 hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) rno-miR-20b-5p predicted by miR-20a (Homo sapiens), and Hif1a predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 4497 rno-miR-384-5p miR-30abcdef/30abe-5p/384-5p MIMAT0005309 miRNA Bnip3l autophagy down Rattus norvegicus prediction 10116 140923 Nix RGD:621354|Ensembl:ENSRNOG00000009820 15 15p12 BCL2/adenovirus E1B interacting protein 3-like protein-coding BCL2/adenovirus E1B interacting protein 3-like rno-miR-384-5p predicted by miR-30d (Homo sapiens), and Bnip3l predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 4498 rno-let-7e let-7/98/4458/4500 MIMAT0000777 miRNA Mtor autophagy down Rattus norvegicus prediction 10116 56718 Frap1|RAFT1 RGD:68371|Ensembl:ENSRNOG00000009615 5 5q36 mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) rno-let-7e predicted by let-7 (Homo sapiens), and Mtor predicted by MTOR (Homo sapiens) according to Pubmed ID (25295787) 4499 rno-miR-15b miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000784 miRNA Atg7 autophagy down Rattus norvegicus prediction 10116 312647 Apg7l RGD:1304817|Ensembl:ENSRNOG00000007486 4 4q42 autophagy related 7 protein-coding autophagy related 7 rno-miR-15b predicted by miR-16 (Homo sapiens), and Atg7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23143396) 4500 rno-miR-384-5p miR-30abcdef/30abe-5p/384-5p MIMAT0005309 miRNA Becn1 autophagy down Rattus norvegicus prediction 10116 114558 - RGD:620190|Ensembl:ENSRNOG00000020513 10 10q32.1 beclin 1, autophagy related protein-coding beclin 1, autophagy related rno-miR-384-5p predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and Becn1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 4501 rno-miR-34c miR-34ac/34bc-5p/449abc/449c-5p MIMAT0000814 miRNA Atg9a autophagy down Rattus norvegicus prediction 10116 363254 RGD1310450 RGD:1310450|Ensembl:ENSRNOG00000018975 9 9q33 autophagy related 9A protein-coding autophagy related 9A rno-miR-34c predicted by miR-34a (Homo sapiens),miR-34a (Rattus norvegicus), and Atg9a predicted by Atg9a (Rattus norvegicus),ATG9A (Homo sapiens) according to Pubmed ID (22902544),(24728149),(24973144) 4502 rno-let-7c let-7/98/4458/4500 MIMAT0000776 miRNA Igf1r autophagy down Rattus norvegicus prediction 10116 25718 IGFIRC|JTK13 RGD:2869|Ensembl:ENSRNOG00000014187 1 1q22 insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor rno-let-7c predicted by let-7i (Homo sapiens), and Igf1r predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 4503 rno-miR-182 miR-182 MIMAT0005300 miRNA Foxo3 autophagy down Rattus norvegicus prediction 10116 294515 Fkhrl1|Foxo3a RGD:1309196|Ensembl:ENSRNOG00000000299 20 20q13 forkhead box O3 protein-coding forkhead box O3 rno-miR-182 predicted by miR-182 (Homo sapiens), and Foxo3 predicted by FOXO3 (Homo sapiens) according to Pubmed ID (24871856) 4504 rno-let-7a let-7/98/4458/4500 MIMAT0000774 miRNA Igf1r autophagy down Rattus norvegicus prediction 10116 25718 IGFIRC|JTK13 RGD:2869|Ensembl:ENSRNOG00000014187 1 1q22 insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor rno-let-7a predicted by let-7i (Homo sapiens), and Igf1r predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 4505 rno-let-7d let-7/98/4458/4500 MIMAT0000562 miRNA Igf1r autophagy down Rattus norvegicus prediction 10116 25718 IGFIRC|JTK13 RGD:2869|Ensembl:ENSRNOG00000014187 1 1q22 insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor rno-let-7d predicted by let-7i (Homo sapiens), and Igf1r predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 4506 rno-miR-204 miR-204/204b/211 MIMAT0000877 miRNA Map1lc3b autophagy down Rattus norvegicus prediction 10116 64862 Map1lc3|Mpl3|zbs559 RGD:621315|Ensembl:ENSRNOG00000017905 19 19q12 microtubule-associated protein 1 light chain 3 beta protein-coding microtubule-associated protein 1 light chain 3 beta rno-miR-204 predicted by miR-204 (Homo sapiens),miR-204 (Rattus norvegicus), and Map1lc3b predicted by Map1lc3b (Rattus norvegicus),MAP1LC3B (Homo sapiens) according to Pubmed ID (21316776),(21631941),(22516261),(25209181),(25517751) 4507 rno-let-7f let-7/98/4458/4500 MIMAT0000778 miRNA Mtor autophagy down Rattus norvegicus prediction 10116 56718 Frap1|RAFT1 RGD:68371|Ensembl:ENSRNOG00000009615 5 5q36 mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) rno-let-7f predicted by let-7 (Homo sapiens), and Mtor predicted by MTOR (Homo sapiens) according to Pubmed ID (25295787) 4508 rno-let-7d let-7/98/4458/4500 MIMAT0000562 miRNA Olr1 autophagy down Rattus norvegicus prediction 10116 140914 LOX-1|Oldlr1|Oldr1 RGD:620515|Ensembl:ENSRNOG00000008375 4 4q42 oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding oxidized low density lipoprotein (lectin-like) receptor 1 rno-let-7d predicted by let-7g (Mus musculus), and Olr1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 4509 rno-miR-200c miR-200bc/429/548a MIMAT0000873 miRNA Ubqln1 autophagy down Rattus norvegicus prediction 10116 114590 Da41 RGD:620745|Ensembl:ENSRNOG00000019282 17 17p14 ubiquilin 1 protein-coding ubiquilin 1 rno-miR-200c predicted by miR-200c (Homo sapiens), and Ubqln1 predicted by UBQLN1 (Homo sapiens) according to Pubmed ID (25044403) 4510 rno-miR-23b miR-23abc/23b-3p MIMAT0000793 miRNA Atg12 autophagy down Rattus norvegicus prediction 10116 361321 Apg12l RGD:1306306|Ensembl:ENSRNOG00000000157 18 18q11 autophagy related 12 protein-coding autophagy related 12 rno-miR-23b predicted by miR-23b (Homo sapiens), and Atg12 predicted by ATG12 (Homo sapiens) according to Pubmed ID (23916944),(24145177) 4511 rno-miR-7a miR-7/7ab MIMAT0000606 miRNA Egfr autophagy down Rattus norvegicus prediction 10116 24329 ERBB1|ErbB-1|Errp RGD:2543|Ensembl:ENSRNOG00000004332 14 14q22 epidermal growth factor receptor protein-coding epidermal growth factor receptor rno-miR-7a predicted by miR-7 (Homo sapiens), and Egfr predicted by EGFR (Homo sapiens) according to Pubmed ID (22492316) 4512 rno-miR-130b miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0000837 miRNA Rb1cc1 autophagy down Rattus norvegicus prediction 10116 312927 - RGD:1309346|Ensembl:ENSRNOG00000006833 5 5q12 RB1-inducible coiled-coil 1 protein-coding RB1-inducible coiled-coil 1 rno-miR-130b predicted by miR-133b (Homo sapiens), and Rb1cc1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 4513 rno-miR-25 miR-25/32/92abc/363/363-3p/367 MIMAT0000795 miRNA Ulk1 autophagy down Rattus norvegicus prediction 10116 360827 - RGD:1589743|Ensembl:ENSRNOG00000037505 12 12q16 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 rno-miR-25 predicted by miR-25 (Homo sapiens), and Ulk1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (25026296) 4514 rno-let-7f let-7/98/4458/4500 MIMAT0000778 miRNA Igf1r autophagy down Rattus norvegicus prediction 10116 25718 IGFIRC|JTK13 RGD:2869|Ensembl:ENSRNOG00000014187 1 1q22 insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor rno-let-7f predicted by let-7i (Homo sapiens), and Igf1r predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 4515 rno-miR-20b-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003211 miRNA Sqstm1 autophagy down Rattus norvegicus prediction 10116 113894 Osi|ZIP|ZIP3 RGD:69287|Ensembl:ENSRNOG00000003147 10 10q21 sequestosome 1 protein-coding sequestosome 1 rno-miR-20b-5p predicted by miR-106b (Homo sapiens),miR-106 (Mus musculus), and Sqstm1 predicted by Sqstm1 (Mus musculus),SQSTM1 (Homo sapiens) according to Pubmed ID (21628417),(22441107),(25485521),(25617127) 4516 rno-miR-137 miR-137/137ab MIMAT0000843 miRNA Bnip3l autophagy down Rattus norvegicus prediction 10116 140923 Nix RGD:621354|Ensembl:ENSRNOG00000009820 15 15p12 BCL2/adenovirus E1B interacting protein 3-like protein-coding BCL2/adenovirus E1B interacting protein 3-like rno-miR-137 predicted by miR-137 (Homo sapiens), and Bnip3l predicted by BNIP3L (Homo sapiens) according to Pubmed ID (24573672) 4517 rno-miR-16 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000785 miRNA Bcl2l2 autophagy down Rattus norvegicus prediction 10116 60434 BCL-W|BCL-WEL|BCL-WS|Bclw RGD:620717|Ensembl:ENSRNOG00000015732 15 15p13 Bcl2-like 2 protein-coding Bcl2-like 2 rno-miR-16 predicted by miR-15b (Mus musculus), and Bcl2l2 predicted by Bcl2l2 (Mus musculus) according to Pubmed ID (21770019) 4518 rno-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000602 miRNA Sqstm1 autophagy down Rattus norvegicus prediction 10116 113894 Osi|ZIP|ZIP3 RGD:69287|Ensembl:ENSRNOG00000003147 10 10q21 sequestosome 1 protein-coding sequestosome 1 rno-miR-20a predicted by miR-106b (Homo sapiens),miR-106 (Mus musculus), and Sqstm1 predicted by Sqstm1 (Mus musculus),SQSTM1 (Homo sapiens) according to Pubmed ID (21628417),(22441107),(25485521),(25617127) 4519 rno-miR-93 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000817 miRNA Atg16l1 autophagy down Rattus norvegicus prediction 10116 363278 Apg16l|Wdr30 RGD:1310631|Ensembl:ENSRNOG00000017913 9 9q35 autophagy related 16-like 1 (S. cerevisiae) protein-coding autophagy related 16-like 1 (S. cerevisiae) rno-miR-93 predicted by miR-106b (Homo sapiens), and Atg16l1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 4520 rno-let-7f let-7/98/4458/4500 MIMAT0000778 miRNA Atg4b autophagy down Rattus norvegicus prediction 10116 316640 Apg4b RGD:1309664|Ensembl:ENSRNOG00000018403 9 9q36 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase rno-let-7f predicted by let-7b (Homo sapiens), and Atg4b predicted by ATG4B (Homo sapiens) according to Pubmed ID (22135297) 4521 rno-miR-105 miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0012825 miRNA Ulk1 autophagy down Rattus norvegicus prediction 10116 360827 - RGD:1589743|Ensembl:ENSRNOG00000037505 12 12q16 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 rno-miR-105 predicted by miR-291 (Mus musculus), and Ulk1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 4522 rno-miR-30a miR-30abcdef/30abe-5p/384-5p MIMAT0000808 miRNA Atg12 autophagy down Rattus norvegicus prediction 10116 361321 Apg12l RGD:1306306|Ensembl:ENSRNOG00000000157 18 18q11 autophagy related 12 protein-coding autophagy related 12 rno-miR-30a predicted by miR-30b (Homo sapiens), and Atg12 predicted by ATG12 (Homo sapiens) according to Pubmed ID (22647547),(23274497) 4523 rno-miR-429 miR-200bc/429/548a MIMAT0001538 miRNA Ubqln1 autophagy down Rattus norvegicus prediction 10116 114590 Da41 RGD:620745|Ensembl:ENSRNOG00000019282 17 17p14 ubiquilin 1 protein-coding ubiquilin 1 rno-miR-429 predicted by miR-200c (Homo sapiens), and Ubqln1 predicted by UBQLN1 (Homo sapiens) according to Pubmed ID (25044403) 4524 rno-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000602 miRNA Hif1a autophagy down Rattus norvegicus prediction 10116 29560 MOP1 RGD:61928|Ensembl:ENSRNOG00000008292 6 6q24 hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) rno-miR-20a predicted by miR-20a (Homo sapiens), and Hif1a predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 4525 rno-miR-20b-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003211 miRNA Atg7 autophagy down Rattus norvegicus prediction 10116 312647 Apg7l RGD:1304817|Ensembl:ENSRNOG00000007486 4 4q42 autophagy related 7 protein-coding autophagy related 7 rno-miR-20b-5p predicted by miR-17 (Homo sapiens), and Atg7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 4526 rno-miR-34a miR-34ac/34bc-5p/449abc/449c-5p MIMAT0000815 miRNA Atg9a autophagy down Rattus norvegicus prediction 10116 363254 RGD1310450 RGD:1310450|Ensembl:ENSRNOG00000018975 9 9q33 autophagy related 9A protein-coding autophagy related 9A rno-miR-34a predicted by miR-34a (Homo sapiens),miR-34a (Rattus norvegicus), and Atg9a predicted by Atg9a (Rattus norvegicus),ATG9A (Homo sapiens) according to Pubmed ID (22902544),(24728149),(24973144) 4527 rno-miR-100 miR-99ab/100 MIMAT0000822 miRNA Mtor autophagy down Rattus norvegicus prediction 10116 56718 Frap1|RAFT1 RGD:68371|Ensembl:ENSRNOG00000009615 5 5q36 mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) rno-miR-100 predicted by miR-100 (Homo sapiens), and Mtor predicted by MTOR (Homo sapiens) according to Pubmed ID (25026290) 4528 rno-miR-93 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000817 miRNA Fyco1 autophagy down Rattus norvegicus prediction 10116 301085 - RGD:1309069|Ensembl:ENSRNOG00000006336 8 8q32 FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 rno-miR-93 predicted by miR-93 (Homo sapiens), and Fyco1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 4529 rno-miR-29b miR-29abcd MIMAT0000801 miRNA Atg9a autophagy down Rattus norvegicus prediction 10116 363254 RGD1310450 RGD:1310450|Ensembl:ENSRNOG00000018975 9 9q33 autophagy related 9A protein-coding autophagy related 9A rno-miR-29b predicted by miR-29b (Bos taurus), and Atg9a predicted by ATG9A (Bos taurus) according to Pubmed ID (25234643) 4530 rno-let-7e let-7/98/4458/4500 MIMAT0000777 miRNA Igf1r autophagy down Rattus norvegicus prediction 10116 25718 IGFIRC|JTK13 RGD:2869|Ensembl:ENSRNOG00000014187 1 1q22 insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor rno-let-7e predicted by let-7i (Homo sapiens), and Igf1r predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 4531 rno-let-7b let-7/98/4458/4500 MIMAT0000775 miRNA Olr1 autophagy down Rattus norvegicus prediction 10116 140914 LOX-1|Oldlr1|Oldr1 RGD:620515|Ensembl:ENSRNOG00000008375 4 4q42 oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding oxidized low density lipoprotein (lectin-like) receptor 1 rno-let-7b predicted by let-7g (Mus musculus), and Olr1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 4532 rno-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000602 miRNA Atg16l1 autophagy down Rattus norvegicus prediction 10116 363278 Apg16l|Wdr30 RGD:1310631|Ensembl:ENSRNOG00000017913 9 9q35 autophagy related 16-like 1 (S. cerevisiae) protein-coding autophagy related 16-like 1 (S. cerevisiae) rno-miR-20a predicted by miR-106b (Homo sapiens), and Atg16l1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 4533 rno-miR-148b-3p miR-148ab-3p/152 MIMAT0000579 miRNA Atg14 autophagy down Rattus norvegicus prediction 10116 305831 Atg14L|RGD1304610 RGD:1304610|Ensembl:ENSRNOG00000011873 15 15p14 autophagy related 14 protein-coding autophagy related 14 rno-miR-148b-3p predicted by miR-152 (Homo sapiens), and Atg14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (25650716) 4534 rno-miR-15b miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000784 miRNA Bag5 autophagy down Rattus norvegicus prediction 10116 366734 - RGD:1310847|Ensembl:ENSRNOG00000011527 6 6q32 BCL2-associated athanogene 5 protein-coding BCL2-associated athanogene 5 rno-miR-15b predicted by miR-16 (Mus musculus), and Bag5 predicted by Bag5 (Mus musculus) according to Pubmed ID (21770019) 4535 rno-miR-96 miR-96/507/1271 MIMAT0000818 miRNA Mtor autophagy down Rattus norvegicus prediction 10116 56718 Frap1|RAFT1 RGD:68371|Ensembl:ENSRNOG00000009615 5 5q36 mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) rno-miR-96 predicted by miR-96 (Homo sapiens), and Mtor predicted by MTOR (Homo sapiens) according to Pubmed ID (25333253) 4536 rno-miR-384-5p miR-30abcdef/30abe-5p/384-5p MIMAT0005309 miRNA Atg12 autophagy down Rattus norvegicus prediction 10116 361321 Apg12l RGD:1306306|Ensembl:ENSRNOG00000000157 18 18q11 autophagy related 12 protein-coding autophagy related 12 rno-miR-384-5p predicted by miR-30b (Homo sapiens), and Atg12 predicted by ATG12 (Homo sapiens) according to Pubmed ID (22647547),(23274497) 4537 rno-miR-182 miR-182 MIMAT0005300 miRNA Bcl2 autophagy down Rattus norvegicus prediction 10116 24224 Bcl-2 RGD:2199|Ensembl:ENSRNOG00000002791 13 13p13 B-cell CLL/lymphoma 2 protein-coding B-cell CLL/lymphoma 2 rno-miR-182 predicted by miR-182 (Homo sapiens), and Bcl2 predicted by BCL2 (Homo sapiens) according to Pubmed ID (23936432) 4538 rno-let-7a let-7/98/4458/4500 MIMAT0000774 miRNA Atg4b autophagy down Rattus norvegicus prediction 10116 316640 Apg4b RGD:1309664|Ensembl:ENSRNOG00000018403 9 9q36 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase rno-let-7a predicted by let-7b (Homo sapiens), and Atg4b predicted by ATG4B (Homo sapiens) according to Pubmed ID (22135297) 4539 rno-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000825 miRNA Hif1a autophagy down Rattus norvegicus prediction 10116 29560 MOP1 RGD:61928|Ensembl:ENSRNOG00000008292 6 6q24 hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) rno-miR-106b predicted by miR-20a (Homo sapiens), and Hif1a predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 4540 rno-miR-17-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000786 miRNA Atg16l1 autophagy down Rattus norvegicus prediction 10116 363278 Apg16l|Wdr30 RGD:1310631|Ensembl:ENSRNOG00000017913 9 9q35 autophagy related 16-like 1 (S. cerevisiae) protein-coding autophagy related 16-like 1 (S. cerevisiae) rno-miR-17-5p predicted by miR-106b (Homo sapiens), and Atg16l1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 4541 rno-miR-20b-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003211 miRNA Fyco1 autophagy down Rattus norvegicus prediction 10116 301085 - RGD:1309069|Ensembl:ENSRNOG00000006336 8 8q32 FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 rno-miR-20b-5p predicted by miR-93 (Homo sapiens), and Fyco1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 4542 rno-miR-34c miR-34ac/34bc-5p/449abc/449c-5p MIMAT0000814 miRNA Atg4b autophagy down Rattus norvegicus prediction 10116 316640 Apg4b RGD:1309664|Ensembl:ENSRNOG00000018403 9 9q36 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase rno-miR-34c predicted by miR-34a (Homo sapiens), and Atg4b predicted by ATG4B (Homo sapiens) according to Pubmed ID (24755409) 4543 rno-miR-99b miR-99ab/100 MIMAT0000821 miRNA Mtor autophagy down Rattus norvegicus prediction 10116 56718 Frap1|RAFT1 RGD:68371|Ensembl:ENSRNOG00000009615 5 5q36 mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) rno-miR-99b predicted by miR-100 (Homo sapiens), and Mtor predicted by MTOR (Homo sapiens) according to Pubmed ID (25026290) 4544 rno-let-7c let-7/98/4458/4500 MIMAT0000776 miRNA Mtor autophagy down Rattus norvegicus prediction 10116 56718 Frap1|RAFT1 RGD:68371|Ensembl:ENSRNOG00000009615 5 5q36 mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) rno-let-7c predicted by let-7 (Homo sapiens), and Mtor predicted by MTOR (Homo sapiens) according to Pubmed ID (25295787) 4545 rno-miR-195 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000870 miRNA Bag5 autophagy down Rattus norvegicus prediction 10116 366734 - RGD:1310847|Ensembl:ENSRNOG00000011527 6 6q32 BCL2-associated athanogene 5 protein-coding BCL2-associated athanogene 5 rno-miR-195 predicted by miR-16 (Mus musculus), and Bag5 predicted by Bag5 (Mus musculus) according to Pubmed ID (21770019) 4546 rno-miR-18a miR-18ab/4735-3p MIMAT0000787 miRNA Atm autophagy down Rattus norvegicus prediction 10116 300711 - RGD:1593265|Ensembl:ENSRNOG00000029773 8 8q24 ATM serine/threonine kinase protein-coding ATM serine/threonine kinase rno-miR-18a predicted by miR-18a (Homo sapiens), and Atm predicted by ATM (Homo sapiens) according to Pubmed ID (23229340) 4547 rno-miR-290 miR-290-5p/292-5p/371-5p/293 MIMAT0000893 miRNA Ulk1 autophagy down Rattus norvegicus prediction 10116 360827 - RGD:1589743|Ensembl:ENSRNOG00000037505 12 12q16 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 rno-miR-290 predicted by miR-290 (Mus musculus), and Ulk1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 4548 rno-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000825 miRNA Ulk1 autophagy down Rattus norvegicus prediction 10116 360827 - RGD:1589743|Ensembl:ENSRNOG00000037505 12 12q16 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 rno-miR-106b predicted by miR-106b (Homo sapiens), and Ulk1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 4549 rno-miR-199a-5p miR-199ab-5p MIMAT0000872 miRNA Hspa5 autophagy down Rattus norvegicus prediction 10116 25617 BIP|GRP78 RGD:2843|Ensembl:ENSRNOG00000018294 3 3p11 heat shock protein 5 protein-coding heat shock protein 5 rno-miR-199a-5p predicted by miR-199a-5p (Mus musculus), and Hspa5 predicted by Hspa5 (Mus musculus) according to Pubmed ID (23598416) 4550 rno-let-7i let-7/98/4458/4500 MIMAT0000779 miRNA Atg4b autophagy down Rattus norvegicus prediction 10116 316640 Apg4b RGD:1309664|Ensembl:ENSRNOG00000018403 9 9q36 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase rno-let-7i predicted by let-7b (Homo sapiens), and Atg4b predicted by ATG4B (Homo sapiens) according to Pubmed ID (22135297) 4551 rno-miR-497 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0003383 miRNA Atg7 autophagy down Rattus norvegicus prediction 10116 312647 Apg7l RGD:1304817|Ensembl:ENSRNOG00000007486 4 4q42 autophagy related 7 protein-coding autophagy related 7 rno-miR-497 predicted by miR-16 (Homo sapiens), and Atg7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23143396) 4552 rno-let-7i let-7/98/4458/4500 MIMAT0000779 miRNA Olr1 autophagy down Rattus norvegicus prediction 10116 140914 LOX-1|Oldlr1|Oldr1 RGD:620515|Ensembl:ENSRNOG00000008375 4 4q42 oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding oxidized low density lipoprotein (lectin-like) receptor 1 rno-let-7i predicted by let-7g (Mus musculus), and Olr1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 4553 rno-miR-292-5p miR-290-5p/292-5p/371-5p/293 MIMAT0000896 miRNA Ulk1 autophagy down Rattus norvegicus prediction 10116 360827 - RGD:1589743|Ensembl:ENSRNOG00000037505 12 12q16 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 rno-miR-292-5p predicted by miR-290 (Mus musculus), and Ulk1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 4554 rno-miR-29b miR-29abcd MIMAT0000801 miRNA Psme4 autophagy down Rattus norvegicus prediction 10116 498433 - RGD:1591971|Ensembl:ENSRNOG00000006609 14 14q22 proteasome (prosome, macropain) activator subunit 4 protein-coding proteasome (prosome, macropain) activator subunit 4 rno-miR-29b predicted by miR-29b (Homo sapiens), and Psme4 predicted by PSME4 (Homo sapiens) according to Pubmed ID (25234165) 4555 rno-miR-132 miR-132/212/212-3p MIMAT0000838 miRNA Foxo3 autophagy down Rattus norvegicus prediction 10116 294515 Fkhrl1|Foxo3a RGD:1309196|Ensembl:ENSRNOG00000000299 20 20q13 forkhead box O3 protein-coding forkhead box O3 rno-miR-132 predicted by miR-132 (Mus musculus), and Foxo3 predicted by Foxo3 (Mus musculus) according to Pubmed ID (23011132) 4556 rno-miR-92a miR-25/32/92abc/363/363-3p/367 MIMAT0000816 miRNA Ulk1 autophagy down Rattus norvegicus prediction 10116 360827 - RGD:1589743|Ensembl:ENSRNOG00000037505 12 12q16 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 rno-miR-92a predicted by miR-25 (Homo sapiens), and Ulk1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (25026296) 4557 rno-miR-449a miR-34ac/34bc-5p/449abc/449c-5p MIMAT0001543 miRNA Atg4b autophagy down Rattus norvegicus prediction 10116 316640 Apg4b RGD:1309664|Ensembl:ENSRNOG00000018403 9 9q36 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase rno-miR-449a predicted by miR-34a (Homo sapiens), and Atg4b predicted by ATG4B (Homo sapiens) according to Pubmed ID (24755409) 4558 rno-miR-101b miR-101/101ab MIMAT0000615 miRNA Stmn1 autophagy down Rattus norvegicus prediction 10116 29332 Lap18|OP18|PP17|PP19|PR22|SMN|prosolin RGD:2992|Ensembl:ENSRNOG00000016810 5 5q36 stathmin 1 protein-coding stathmin 1 rno-miR-101b predicted by miR-101 (Homo sapiens), and Stmn1 predicted by STMN1 (Homo sapiens) according to Pubmed ID (21915098),(23483142),(25607713) 4559 rno-miR-224 miR-224 MIMAT0003119 miRNA Smad4 autophagy down Rattus norvegicus prediction 10116 50554 Madh4 RGD:3033|Ensembl:ENSRNOG00000015634 18 18q12.3 SMAD family member 4 protein-coding SMAD family member 4 rno-miR-224 predicted by miR-224 (Homo sapiens), and Smad4 predicted by SMAD4 (Homo sapiens) according to Pubmed ID (23913306),(25068270) 4560 rno-miR-30e miR-30abcdef/30abe-5p/384-5p MIMAT0000805 miRNA Atg12 autophagy down Rattus norvegicus prediction 10116 361321 Apg12l RGD:1306306|Ensembl:ENSRNOG00000000157 18 18q11 autophagy related 12 protein-coding autophagy related 12 rno-miR-30e predicted by miR-30b (Homo sapiens), and Atg12 predicted by ATG12 (Homo sapiens) according to Pubmed ID (22647547),(23274497) 4561 rno-miR-29a miR-29abcd MIMAT0000802 miRNA Atg9a autophagy down Rattus norvegicus prediction 10116 363254 RGD1310450 RGD:1310450|Ensembl:ENSRNOG00000018975 9 9q33 autophagy related 9A protein-coding autophagy related 9A rno-miR-29a predicted by miR-29b (Bos taurus), and Atg9a predicted by ATG9A (Bos taurus) according to Pubmed ID (25234643) 4562 rno-miR-101b miR-101/101ab MIMAT0000615 miRNA LOC100361891 autophagy down Rattus norvegicus prediction 10116 100361891 rno-miR-101b predicted by miR-101 (Homo sapiens), and LOC100361891 predicted by RAB5A (Homo sapiens) according to Pubmed ID (21915098),(23483142),(25606826) 4563 rno-miR-322 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0001619 miRNA Atg7 autophagy down Rattus norvegicus prediction 10116 312647 Apg7l RGD:1304817|Ensembl:ENSRNOG00000007486 4 4q42 autophagy related 7 protein-coding autophagy related 7 rno-miR-322 predicted by miR-16 (Homo sapiens), and Atg7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23143396) 4564 rno-miR-22 miR-22/22-3p MIMAT0000791 miRNA Btg1 autophagy down Rattus norvegicus prediction 10116 29618 - RGD:2224|Ensembl:ENSRNOG00000004284 7 7q13 B-cell translocation gene 1, anti-proliferative protein-coding B-cell translocation gene 1, anti-proliferative rno-miR-22 predicted by miR-22 (Homo sapiens), and Btg1 predicted by BTG1 (Homo sapiens) according to Pubmed ID (25449431) 4565 rno-miR-17-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000786 miRNA Hif1a autophagy down Rattus norvegicus prediction 10116 29560 MOP1 RGD:61928|Ensembl:ENSRNOG00000008292 6 6q24 hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) protein-coding hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) rno-miR-17-5p predicted by miR-20a (Homo sapiens), and Hif1a predicted by HIF1A (Homo sapiens) according to Pubmed ID (25485521) 4566 rno-miR-291a-3p miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0000895 miRNA Ulk1 autophagy down Rattus norvegicus prediction 10116 360827 - RGD:1589743|Ensembl:ENSRNOG00000037505 12 12q16 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 rno-miR-291a-3p predicted by miR-291 (Mus musculus), and Ulk1 predicted by Ulk1 (Mus musculus) according to Pubmed ID (23150779) 4567 rno-miR-375 miR-375 MIMAT0005307 miRNA Sp1 autophagy down Rattus norvegicus prediction 10116 24790 - RGD:3738|Ensembl:ENSRNOG00000014084 7 7q36 Sp1 transcription factor protein-coding Sp1 transcription factor rno-miR-375 predicted by miR-375 (Homo sapiens), and Sp1 predicted by SP1 (Homo sapiens) according to Pubmed ID (22606351) 4568 rno-miR-212 miR-132/212/212-3p MIMAT0000883 miRNA Foxo3 autophagy down Rattus norvegicus prediction 10116 294515 Fkhrl1|Foxo3a RGD:1309196|Ensembl:ENSRNOG00000000299 20 20q13 forkhead box O3 protein-coding forkhead box O3 rno-miR-212 predicted by miR-132 (Mus musculus), and Foxo3 predicted by Foxo3 (Mus musculus) according to Pubmed ID (23011132) 4569 rno-miR-144 miR-144 MIMAT0000850 miRNA Gsk3b autophagy down Rattus norvegicus prediction 10116 84027 - RGD:70982|Ensembl:ENSRNOG00000002833 11 11q21 glycogen synthase kinase 3 beta protein-coding glycogen synthase kinase 3 beta rno-miR-144 predicted by miR-144 (Homo sapiens), and Gsk3b predicted by GSK3B (Homo sapiens) according to Pubmed ID (25060662) 4570 rno-miR-98 let-7/98/4458/4500 MIMAT0000819 miRNA Mtor autophagy down Rattus norvegicus prediction 10116 56718 Frap1|RAFT1 RGD:68371|Ensembl:ENSRNOG00000009615 5 5q36 mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) rno-miR-98 predicted by let-7 (Homo sapiens), and Mtor predicted by MTOR (Homo sapiens) according to Pubmed ID (25295787) 4571 rno-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000602 miRNA Fyco1 autophagy down Rattus norvegicus prediction 10116 301085 - RGD:1309069|Ensembl:ENSRNOG00000006336 8 8q32 FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 rno-miR-20a predicted by miR-93 (Homo sapiens), and Fyco1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 4572 rno-miR-101a miR-101/101ab MIMAT0000823 miRNA LOC100361891 autophagy down Rattus norvegicus prediction 10116 100361891 rno-miR-101a predicted by miR-101 (Homo sapiens), and LOC100361891 predicted by RAB5A (Homo sapiens) according to Pubmed ID (21915098),(23483142),(25606826) 4573 rno-miR-101a miR-101/101ab MIMAT0000823 miRNA Stmn1 autophagy down Rattus norvegicus prediction 10116 29332 Lap18|OP18|PP17|PP19|PR22|SMN|prosolin RGD:2992|Ensembl:ENSRNOG00000016810 5 5q36 stathmin 1 protein-coding stathmin 1 rno-miR-101a predicted by miR-101 (Homo sapiens), and Stmn1 predicted by STMN1 (Homo sapiens) according to Pubmed ID (21915098),(23483142),(25607713) 4574 rno-let-7e let-7/98/4458/4500 MIMAT0000777 miRNA Atg4b autophagy down Rattus norvegicus prediction 10116 316640 Apg4b RGD:1309664|Ensembl:ENSRNOG00000018403 9 9q36 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase rno-let-7e predicted by let-7b (Homo sapiens), and Atg4b predicted by ATG4B (Homo sapiens) according to Pubmed ID (22135297) 4575 rno-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000825 miRNA Atg16l1 autophagy down Rattus norvegicus prediction 10116 363278 Apg16l|Wdr30 RGD:1310631|Ensembl:ENSRNOG00000017913 9 9q35 autophagy related 16-like 1 (S. cerevisiae) protein-coding autophagy related 16-like 1 (S. cerevisiae) rno-miR-106b predicted by miR-106b (Homo sapiens), and Atg16l1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 4576 rno-miR-322 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0001619 miRNA Bcl2l2 autophagy down Rattus norvegicus prediction 10116 60434 BCL-W|BCL-WEL|BCL-WS|Bclw RGD:620717|Ensembl:ENSRNOG00000015732 15 15p13 Bcl2-like 2 protein-coding Bcl2-like 2 rno-miR-322 predicted by miR-15b (Mus musculus), and Bcl2l2 predicted by Bcl2l2 (Mus musculus) according to Pubmed ID (21770019) 4577 rno-let-7b let-7/98/4458/4500 MIMAT0000775 miRNA Igf1r autophagy down Rattus norvegicus prediction 10116 25718 IGFIRC|JTK13 RGD:2869|Ensembl:ENSRNOG00000014187 1 1q22 insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor rno-let-7b predicted by let-7i (Homo sapiens), and Igf1r predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 4578 rno-miR-96 miR-96/507/1271 MIMAT0000818 miRNA Atg7 autophagy down Rattus norvegicus prediction 10116 312647 Apg7l RGD:1304817|Ensembl:ENSRNOG00000007486 4 4q42 autophagy related 7 protein-coding autophagy related 7 rno-miR-96 predicted by miR-96 (Homo sapiens), and Atg7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (25333253) 4579 rno-miR-30d miR-30abcdef/30abe-5p/384-5p MIMAT0000807 miRNA Atg12 autophagy down Rattus norvegicus prediction 10116 361321 Apg12l RGD:1306306|Ensembl:ENSRNOG00000000157 18 18q11 autophagy related 12 protein-coding autophagy related 12 rno-miR-30d predicted by miR-30b (Homo sapiens), and Atg12 predicted by ATG12 (Homo sapiens) according to Pubmed ID (22647547),(23274497) 4580 rno-miR-23a miR-23abc/23b-3p MIMAT0000792 miRNA Atg12 autophagy down Rattus norvegicus prediction 10116 361321 Apg12l RGD:1306306|Ensembl:ENSRNOG00000000157 18 18q11 autophagy related 12 protein-coding autophagy related 12 rno-miR-23a predicted by miR-23b (Homo sapiens), and Atg12 predicted by ATG12 (Homo sapiens) according to Pubmed ID (23916944),(24145177) 4581 rno-miR-93 miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000817 miRNA Atg7 autophagy down Rattus norvegicus prediction 10116 312647 Apg7l RGD:1304817|Ensembl:ENSRNOG00000007486 4 4q42 autophagy related 7 protein-coding autophagy related 7 rno-miR-93 predicted by miR-17 (Homo sapiens), and Atg7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23792642),(25485521),(25617127) 4582 rno-miR-30c miR-30abcdef/30abe-5p/384-5p MIMAT0000804 miRNA Bnip3l autophagy down Rattus norvegicus prediction 10116 140923 Nix RGD:621354|Ensembl:ENSRNOG00000009820 15 15p12 BCL2/adenovirus E1B interacting protein 3-like protein-coding BCL2/adenovirus E1B interacting protein 3-like rno-miR-30c predicted by miR-30d (Homo sapiens), and Bnip3l predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 4583 rno-miR-497 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0003383 miRNA Bag5 autophagy down Rattus norvegicus prediction 10116 366734 - RGD:1310847|Ensembl:ENSRNOG00000011527 6 6q32 BCL2-associated athanogene 5 protein-coding BCL2-associated athanogene 5 rno-miR-497 predicted by miR-16 (Mus musculus), and Bag5 predicted by Bag5 (Mus musculus) according to Pubmed ID (21770019) 4584 rno-miR-99a miR-99ab/100 MIMAT0000820 miRNA Igf1r autophagy down Rattus norvegicus prediction 10116 25718 IGFIRC|JTK13 RGD:2869|Ensembl:ENSRNOG00000014187 1 1q22 insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor rno-miR-99a predicted by miR-100 (Homo sapiens), and Igf1r predicted by IGF1R (Homo sapiens) according to Pubmed ID (25026290) 4585 rno-miR-195 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000870 miRNA Bcl2l2 autophagy down Rattus norvegicus prediction 10116 60434 BCL-W|BCL-WEL|BCL-WS|Bclw RGD:620717|Ensembl:ENSRNOG00000015732 15 15p13 Bcl2-like 2 protein-coding Bcl2-like 2 rno-miR-195 predicted by miR-15b (Mus musculus), and Bcl2l2 predicted by Bcl2l2 (Mus musculus) according to Pubmed ID (21770019) 4586 rno-miR-30a miR-30abcdef/30abe-5p/384-5p MIMAT0000808 miRNA Becn1 autophagy down Rattus norvegicus prediction 10116 114558 - RGD:620190|Ensembl:ENSRNOG00000020513 10 10q32.1 beclin 1, autophagy related protein-coding beclin 1, autophagy related rno-miR-30a predicted by miR-30a (Homo sapiens),miR-30a (Mus musculus), and Becn1 predicted by BECN1 (Homo sapiens),Becn1 (Mus musculus) according to Pubmed ID (19535919),(22157765),(22617440),(22647547),(22902544),(23274497),(23326547),(23660952),(24345332),(24676932),(24771295),(25501305),(25620738),(25712526) 4587 rno-let-7i let-7/98/4458/4500 MIMAT0000779 miRNA Igf1r autophagy down Rattus norvegicus prediction 10116 25718 IGFIRC|JTK13 RGD:2869|Ensembl:ENSRNOG00000014187 1 1q22 insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor rno-let-7i predicted by let-7i (Homo sapiens), and Igf1r predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 4588 rno-let-7a let-7/98/4458/4500 MIMAT0000774 miRNA Mtor autophagy down Rattus norvegicus prediction 10116 56718 Frap1|RAFT1 RGD:68371|Ensembl:ENSRNOG00000009615 5 5q36 mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) rno-let-7a predicted by let-7 (Homo sapiens), and Mtor predicted by MTOR (Homo sapiens) according to Pubmed ID (25295787) 4589 rno-miR-99a miR-99ab/100 MIMAT0000820 miRNA Mtor autophagy down Rattus norvegicus prediction 10116 56718 Frap1|RAFT1 RGD:68371|Ensembl:ENSRNOG00000009615 5 5q36 mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) rno-miR-99a predicted by miR-100 (Homo sapiens), and Mtor predicted by MTOR (Homo sapiens) according to Pubmed ID (25026290) 4590 rno-miR-30c miR-30abcdef/30abe-5p/384-5p MIMAT0000804 miRNA Atg12 autophagy down Rattus norvegicus prediction 10116 361321 Apg12l RGD:1306306|Ensembl:ENSRNOG00000000157 18 18q11 autophagy related 12 protein-coding autophagy related 12 rno-miR-30c predicted by miR-30b (Homo sapiens), and Atg12 predicted by ATG12 (Homo sapiens) according to Pubmed ID (22647547),(23274497) 4591 rno-miR-101b miR-101/101ab MIMAT0000615 miRNA Ezh2 autophagy down Rattus norvegicus prediction 10116 312299 - RGD:1595860|Ensembl:ENSRNOG00000006048 4 4q24 enhancer of zeste 2 polycomb repressive complex 2 subunit protein-coding enhancer of zeste 2 polycomb repressive complex 2 subunit rno-miR-101b predicted by miR-101 (Homo sapiens), and Ezh2 predicted by EZH2 (Homo sapiens) according to Pubmed ID (24211739) 4592 rno-miR-335 miR-335/335-5p MIMAT0000575 miRNA Sqstm1 autophagy down Rattus norvegicus prediction 10116 113894 Osi|ZIP|ZIP3 RGD:69287|Ensembl:ENSRNOG00000003147 10 10q21 sequestosome 1 protein-coding sequestosome 1 rno-miR-335 predicted by miR-335 (Homo sapiens), and Sqstm1 predicted by SQSTM1 (Homo sapiens) according to Pubmed ID (22135297) 4593 rno-miR-322 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0001619 miRNA Bag5 autophagy down Rattus norvegicus prediction 10116 366734 - RGD:1310847|Ensembl:ENSRNOG00000011527 6 6q32 BCL2-associated athanogene 5 protein-coding BCL2-associated athanogene 5 rno-miR-322 predicted by miR-16 (Mus musculus), and Bag5 predicted by Bag5 (Mus musculus) according to Pubmed ID (21770019) 4594 rno-let-7d let-7/98/4458/4500 MIMAT0000562 miRNA Atg4b autophagy down Rattus norvegicus prediction 10116 316640 Apg4b RGD:1309664|Ensembl:ENSRNOG00000018403 9 9q36 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase rno-let-7d predicted by let-7b (Homo sapiens), and Atg4b predicted by ATG4B (Homo sapiens) according to Pubmed ID (22135297) 4595 rno-miR-301a miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 MIMAT0000552 miRNA Rb1cc1 autophagy down Rattus norvegicus prediction 10116 312927 - RGD:1309346|Ensembl:ENSRNOG00000006833 5 5q12 RB1-inducible coiled-coil 1 protein-coding RB1-inducible coiled-coil 1 rno-miR-301a predicted by miR-133b (Homo sapiens), and Rb1cc1 predicted by RB1CC1 (Homo sapiens) according to Pubmed ID (23451058) 4596 rno-miR-291a-3p miR-93/93a/105/106a/291a-3p/294/295/302abcde/372/373/428/519a/520be/520acd-3p/1378/1420ac MIMAT0000895 miRNA Atg7 autophagy down Rattus norvegicus prediction 10116 312647 Apg7l RGD:1304817|Ensembl:ENSRNOG00000007486 4 4q42 autophagy related 7 protein-coding autophagy related 7 rno-miR-291a-3p predicted by miR-291 (Mus musculus), and Atg7 predicted by Atg7 (Mus musculus) according to Pubmed ID (23150779) 4597 rno-miR-20b-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0003211 miRNA Atg16l1 autophagy down Rattus norvegicus prediction 10116 363278 Apg16l|Wdr30 RGD:1310631|Ensembl:ENSRNOG00000017913 9 9q35 autophagy related 16-like 1 (S. cerevisiae) protein-coding autophagy related 16-like 1 (S. cerevisiae) rno-miR-20b-5p predicted by miR-106b (Homo sapiens), and Atg16l1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (23899543),(24036151),(25485521) 4598 rno-miR-20a miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000602 miRNA Ulk1 autophagy down Rattus norvegicus prediction 10116 360827 - RGD:1589743|Ensembl:ENSRNOG00000037505 12 12q16 unc-51 like autophagy activating kinase 1 protein-coding unc-51 like autophagy activating kinase 1 rno-miR-20a predicted by miR-106b (Homo sapiens), and Ulk1 predicted by ULK1 (Homo sapiens) according to Pubmed ID (22781751),(25617127) 4599 rno-miR-375 miR-375 MIMAT0005307 miRNA Ywhaz autophagy down Rattus norvegicus prediction 10116 25578 14-3-3z RGD:3980|Ensembl:ENSRNOG00000008195 7 7q22 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta protein-coding tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta rno-miR-375 predicted by miR-375 (Homo sapiens), and Ywhaz predicted by YWHAZ (Homo sapiens) according to Pubmed ID (22606351) 4600 rno-miR-7b miR-7/7ab MIMAT0000780 miRNA Egfr autophagy down Rattus norvegicus prediction 10116 24329 ERBB1|ErbB-1|Errp RGD:2543|Ensembl:ENSRNOG00000004332 14 14q22 epidermal growth factor receptor protein-coding epidermal growth factor receptor rno-miR-7b predicted by miR-7 (Homo sapiens), and Egfr predicted by EGFR (Homo sapiens) according to Pubmed ID (22492316) 4601 rno-miR-15b miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000784 miRNA Atg14 autophagy down Rattus norvegicus prediction 10116 305831 Atg14L|RGD1304610 RGD:1304610|Ensembl:ENSRNOG00000011873 15 15p14 autophagy related 14 protein-coding autophagy related 14 rno-miR-15b predicted by miR-195 (Homo sapiens), and Atg14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 4602 rno-miR-204 miR-204/204b/211 MIMAT0000877 miRNA Cav1 autophagy down Rattus norvegicus prediction 10116 25404 Cav RGD:2280|Ensembl:ENSRNOG00000006694 4 4q21 caveolin 1, caveolae protein protein-coding caveolin 1, caveolae protein rno-miR-204 predicted by miR-204 (Homo sapiens), and Cav1 predicted by CAV1 (Homo sapiens) according to Pubmed ID (25517751) 4603 rno-miR-222 miR-221/222/222ab/1928 MIMAT0000891 miRNA Cdkn1b autophagy down Rattus norvegicus prediction 10116 83571 CDKN4|Cdki1b|Kip1|P27KIP1|p27 RGD:69062|Ensembl:ENSRNOG00000007249 4 4q43 cyclin-dependent kinase inhibitor 1B protein-coding cyclin-dependent kinase inhibitor 1B rno-miR-222 predicted by miR-221 (Homo sapiens), and Cdkn1b predicted by CDKN1B (Homo sapiens) according to Pubmed ID (25394488) 4604 rno-miR-106b miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000825 miRNA Sqstm1 autophagy down Rattus norvegicus prediction 10116 113894 Osi|ZIP|ZIP3 RGD:69287|Ensembl:ENSRNOG00000003147 10 10q21 sequestosome 1 protein-coding sequestosome 1 rno-miR-106b predicted by miR-106b (Homo sapiens),miR-106 (Mus musculus), and Sqstm1 predicted by Sqstm1 (Mus musculus),SQSTM1 (Homo sapiens) according to Pubmed ID (21628417),(22441107),(25485521),(25617127) 4605 rno-let-7c let-7/98/4458/4500 MIMAT0000776 miRNA Atg4b autophagy down Rattus norvegicus prediction 10116 316640 Apg4b RGD:1309664|Ensembl:ENSRNOG00000018403 9 9q36 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase rno-let-7c predicted by let-7b (Homo sapiens), and Atg4b predicted by ATG4B (Homo sapiens) according to Pubmed ID (22135297) 4606 rno-let-7e let-7/98/4458/4500 MIMAT0000777 miRNA Olr1 autophagy down Rattus norvegicus prediction 10116 140914 LOX-1|Oldlr1|Oldr1 RGD:620515|Ensembl:ENSRNOG00000008375 4 4q42 oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding oxidized low density lipoprotein (lectin-like) receptor 1 rno-let-7e predicted by let-7g (Mus musculus), and Olr1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 4607 rno-let-7a let-7/98/4458/4500 MIMAT0000774 miRNA Olr1 autophagy down Rattus norvegicus prediction 10116 140914 LOX-1|Oldlr1|Oldr1 RGD:620515|Ensembl:ENSRNOG00000008375 4 4q42 oxidized low density lipoprotein (lectin-like) receptor 1 protein-coding oxidized low density lipoprotein (lectin-like) receptor 1 rno-let-7a predicted by let-7g (Mus musculus), and Olr1 predicted by Olr1 (Mus musculus) according to Pubmed ID (23305858) 4608 rno-miR-30e miR-30abcdef/30abe-5p/384-5p MIMAT0000805 miRNA Bnip3l autophagy down Rattus norvegicus prediction 10116 140923 Nix RGD:621354|Ensembl:ENSRNOG00000009820 15 15p12 BCL2/adenovirus E1B interacting protein 3-like protein-coding BCL2/adenovirus E1B interacting protein 3-like rno-miR-30e predicted by miR-30d (Homo sapiens), and Bnip3l predicted by BNIP3L (Homo sapiens) according to Pubmed ID (23274497) 4609 rno-let-7i let-7/98/4458/4500 MIMAT0000779 miRNA Mtor autophagy down Rattus norvegicus prediction 10116 56718 Frap1|RAFT1 RGD:68371|Ensembl:ENSRNOG00000009615 5 5q36 mechanistic target of rapamycin (serine/threonine kinase) protein-coding mechanistic target of rapamycin (serine/threonine kinase) rno-let-7i predicted by let-7 (Homo sapiens), and Mtor predicted by MTOR (Homo sapiens) according to Pubmed ID (25295787) 4610 rno-miR-98 let-7/98/4458/4500 MIMAT0000819 miRNA Igf1r autophagy down Rattus norvegicus prediction 10116 25718 IGFIRC|JTK13 RGD:2869|Ensembl:ENSRNOG00000014187 1 1q22 insulin-like growth factor 1 receptor protein-coding insulin-like growth factor 1 receptor rno-miR-98 predicted by let-7i (Homo sapiens), and Igf1r predicted by IGF1R (Homo sapiens) according to Pubmed ID (25305490) 4611 rno-miR-17-5p miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d MIMAT0000786 miRNA Fyco1 autophagy down Rattus norvegicus prediction 10116 301085 - RGD:1309069|Ensembl:ENSRNOG00000006336 8 8q32 FYVE and coiled-coil domain containing 1 protein-coding FYVE and coiled-coil domain containing 1 rno-miR-17-5p predicted by miR-93 (Homo sapiens), and Fyco1 predicted by FYCO1 (Homo sapiens) according to Pubmed ID (22135297) 4612 rno-miR-195 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000870 miRNA Atg7 autophagy down Rattus norvegicus prediction 10116 312647 Apg7l RGD:1304817|Ensembl:ENSRNOG00000007486 4 4q42 autophagy related 7 protein-coding autophagy related 7 rno-miR-195 predicted by miR-16 (Homo sapiens), and Atg7 predicted by ATG7 (Homo sapiens) according to Pubmed ID (23143396) 4613 rno-miR-142-3p miR-142-3p MIMAT0000848 miRNA Atg16l1 autophagy down Rattus norvegicus prediction 10116 363278 Apg16l|Wdr30 RGD:1310631|Ensembl:ENSRNOG00000017913 9 9q35 autophagy related 16-like 1 (S. cerevisiae) protein-coding autophagy related 16-like 1 (S. cerevisiae) rno-miR-142-3p predicted by miR-142-3p (Homo sapiens), and Atg16l1 predicted by ATG16L1 (Homo sapiens) according to Pubmed ID (24401604) 4614 rno-miR-195 miR-15abc/16/16abc/195/322/424/497/1907 MIMAT0000870 miRNA Atg14 autophagy down Rattus norvegicus prediction 10116 305831 Atg14L|RGD1304610 RGD:1304610|Ensembl:ENSRNOG00000011873 15 15p14 autophagy related 14 protein-coding autophagy related 14 rno-miR-195 predicted by miR-195 (Homo sapiens), and Atg14 predicted by ATG14 (Homo sapiens) according to Pubmed ID (23361941) 4615 rno-miR-98 let-7/98/4458/4500 MIMAT0000819 miRNA Atg4b autophagy down Rattus norvegicus prediction 10116 316640 Apg4b RGD:1309664|Ensembl:ENSRNOG00000018403 9 9q36 autophagy related 4B, cysteine peptidase protein-coding autophagy related 4B, cysteine peptidase rno-miR-98 predicted by let-7b (Homo sapiens), and Atg4b predicted by ATG4B (Homo sapiens) according to Pubmed ID (22135297)