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Detail Information
Basic information:
Untranslated mRNA: Sponge mRNA
| Related IDs | cncRNA ID | CNC_M_002036 | |
|---|---|---|---|
| Name | USP3 | ||
| Gene ID | 9960 | ||
| Location | Coordinate(Strand) | 15:63504511-63594640(+) | |
| Locus Sequence | |||
| Organism | Homo sapiens | ||
Evidence support:
| In vivo/vitro assay | In vitro assay and in vivo assay (Mouse) | |
|---|---|---|
| Low-throughput method | Transfection assay;Western blotting;qRT-PCR;Luciferase assay;Transwell migration and invasion assay;Wound healing assay | |
| High-throughput method | / | |
| Tissue/Cell | Colorectal tumor sample;Lovo cell;HCT116 cell;SW480 cell;RKO cell | |
| Description of experimental evidence | The mRNA was detected by transfection assay, western blotting, qRT-PCR and luciferase assay in Lovo cell, HCT116 cell, SW480 cell and RKO cell, which can modulate SMAD4 expression in a miRNA dependent, and protein-coding gene independent manner by sponging miR-224. | |
Orthologues:
| Chimpanzee | / |
|---|---|
| Mouse | / |
| Drosophila | / |
| Zebrafish | / |
References:
| PMID | 28655924 |
|---|---|
| Description | Downregulated USP3 mRNA functions as a competitive endogenous RNA of SMAD4 by sponging miR-224 and promotes metastasis in colorectal cancer. |
Related Subcelluar Localization:
| Subcelluar Localization | RLID | Link to RNALocate |
|---|---|---|
| Cytosol | RLID00026759 | Link to RNALocate |
| chromatin | RLID00117342 | Link to RNALocate |
| cytosol | RLID00117343 | Link to RNALocate |
| cytosol | RLID00117344 | Link to RNALocate |
| nucleolus | RLID00117345 | Link to RNALocate |
| nucleoplasm | RLID00117346 | Link to RNALocate |
| nucleus | RLID00117347 | Link to RNALocate |
| nucleus | RLID00117348 | Link to RNALocate |
| nucleus | RLID00117349 | Link to RNALocate |
| exosome | RLID00117350 | Link to RNALocate |
Related Interactions:
Notes: You can browse the related interactions in RNAinter by click the above link (since the interaction entries are too much to show here).