Basic information:

Untranslated mRNA: Sponge mRNA

Related IDs	cncRNA ID	CNC_M_001993
	Name	PDGFRA
	Gene ID	5156
Location	Coordinate(Strand)	4:54229280-54298245(+)
Locus Sequence
Organism	Homo sapiens

Evidence support:

  

In vivo/vitro assay	In vitro assay
Low-throughput method	Transfection assay;Western blotting;qRT-PCR;Luciferase assay;siRNA;Proliferation assay
High-throughput method	/
Tissue/Cell	SNB19 cell;SF188 cell
Description of experimental evidence	The mRNA was detected by transfection assay, western blotting, qRT-PCR, luciferase assay, siRNA and proliferation assay in SNB19 cell and SF188 cell, which can act as a decoy for Pten-targeting microRNAs.

Orthologues:

  

Chimpanzee	ENSPTRG00000016066
Mouse	ENSMUSG00000029231
Drosophila	/
Zebrafish	ENSDARG00000070494

References:

  

PMID

22000015

Description

These include 7,000 genes whose transcripts act as miR sponges and 148 genes that act through alternative, nonsponge interactions. Biochemical analyses in cell lines confirmed that this network regulates established drivers of tumor initiation and subtype implementation, including PTEN, PDGFRA, RB1, VEGFA, STAT3, and RUNX1, suggesting that these interactions mediate crosstalk between canonical oncogenic pathways. See Figure 5A for details.

Related Subcelluar Localization:

  

Subcelluar Localization	RLID	Link to RNALocate
exosome	RLID00084748	Link to RNALocate

Related Diseases:

  

OMIM Phenotype	Phenotype MIM number	Link to OMIM
Gastrointestinal stromal tumor/GIST-plus syndrome, somatic or familial	OMIM:175510	Link to OMIM
Hypereosinophilic syndrome, idiopathic, resistant to imatinib	OMIM:607685	Link to OMIM

Related Interactions:

  

  

   Notes: You can browse the related interactions in RNAinter by click the above link (since the interaction entries are too much to show here).