Basic information:

Untranslated mRNA: Sponge mRNA

Related IDs	cncRNA ID	CNC_M_001564
	Name	ERBB2
	Gene ID	2064
Location	Coordinate(Strand)	17:39687914-39730426(+)
Locus Sequence
Organism	Homo sapiens

Evidence support:

  

In vivo/vitro assay	In vitro assay and in vivo assay (Mouse)
Low-throughput method	Transfection assay;sgRNA-CRISPR/Cas9 system;Western blotting;qRT-PCR;Luciferase assay;RNA immunoprecipitation;Immunohistochemistry
High-throughput method	/
Tissue/Cell	AU565 cell;BT474 cell;T47D cell;MCF7 cell;293T cell
Description of experimental evidence	The mRNA was detected by transfection assay, sgRNA-CRISPR/Cas9 system, qRT-PCR, luciferase assay and RNA immunoprecipitation in AU565 cell, BT474 cell, T47D cell, MCF7 cell and 293T cell, which promote cell proliferation, colony formation, and breast tumor growth by sponging miR-125a, miR125-b

Orthologues:

  

Chimpanzee	ENSPTRG00000009100
Mouse	ENSMUSG00000062312
Drosophila	/
Zebrafish	ENSDARG00000026294

References:

  

PMID	30068375
Description	These results suggest that HER2 3'UTR-mediated HER3 upregulation is involved in breast cell transformation, increased tumor growth, and resistance to anti-HER2 therapy. The combinatorial targeting of HER3 mRNA or miR-125a/b may offer an effective tool for breast cancer therapy.

Related Subcelluar Localization:

  

Subcelluar Localization	RLID	Link to RNALocate
chromatin	RLID00063681	Link to RNALocate
cytosol	RLID00063682	Link to RNALocate
nucleolus	RLID00063683	Link to RNALocate
nucleus	RLID00063684	Link to RNALocate
nucleus	RLID00063685	Link to RNALocate
nucleus	RLID00063686	Link to RNALocate
exosome	RLID00063687	Link to RNALocate
Cytosol	RLID00005588	Link to RNALocate
Ribosome	RLID00005589	Link to RNALocate

Related Diseases:

  

OMIM Phenotype	Phenotype MIM number	Link to OMIM
Adenocarcinoma of lung, somatic	OMIM:211980	Link to OMIM
Gastric cancer, somatic	OMIM:613659	Link to OMIM
Glioblastoma, somatic	OMIM:137800	Link to OMIM

Related Interactions:

  

  

   Notes: You can browse the related interactions in RNAinter by click the above link (since the interaction entries are too much to show here).