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Detail Information
Basic information:
Untranslated mRNA: Sponge mRNA
| Related IDs | cncRNA ID | CNC_M_001954 | |
|---|---|---|---|
| Name | FN1 | ||
| Gene ID | 2335 | ||
| Location | Coordinate(Strand) | 2:215360440-215436073(-) | |
| Locus Sequence | |||
| Organism | Homo sapiens | ||
Evidence support:
| In vivo/vitro assay | In vitro assay and in vivo assay (Mouse) | |
|---|---|---|
| Low-throughput method | Transfection assay;Western blotting;qRT-PCR;Luciferase assay;siRNA;Cell detachment;Cell migration assay;Cell invasion assay;Tumor formation assay;Immunohistochemistry | |
| High-throughput method | / | |
| Tissue/Cell | MDA-MB-231 cell | |
| Description of experimental evidence | The mRNA was detected by transfection assay, western blotting, qRT-PCR, luciferase assay and siRNA in MDA-MB-231 cell, which can induce metastasis by regulating extracellular matrix functions | |
Orthologues:
| Chimpanzee | ENSPTRG00000012892 |
|---|---|
| Mouse | ENSMUSG00000026193 |
| Drosophila | / |
| Zebrafish | ENSDARG00000019815 ENSDARG00000006526 |
References:
| PMID | 22637644 |
|---|---|
| Description | Protein analysis demonstrated that expression of CD44, Col1A1 and FN1 were synergistically upregulated in vitro and in vivo upon transfection of the CD44 3' UTR. The non-coding 3' UTR of CD44 interacts with multiple miRNAs that target extracellular matrix properties and thus can be used to antagonize miRNA activities. |
Related Subcelluar Localization:
| Subcelluar Localization | RLID | Link to RNALocate |
|---|---|---|
| chromatin | RLID00067513 | Link to RNALocate |
| cytosol | RLID00067514 | Link to RNALocate |
| cytosol | RLID00067515 | Link to RNALocate |
| cytosol | RLID00067516 | Link to RNALocate |
| nucleoplasm | RLID00067517 | Link to RNALocate |
| nucleus | RLID00067518 | Link to RNALocate |
| nucleus | RLID00067519 | Link to RNALocate |
| exosome | RLID00067520 | Link to RNALocate |
| Endoplasmic reticulum | RLID00007229 | Link to RNALocate |
| Ribosome | RLID00007230 | Link to RNALocate |
Related Diseases:
| OMIM Phenotype | Phenotype MIM number | Link to OMIM |
|---|---|---|
| Spondylometaphyseal dysplasia, corner fracture type | OMIM:184255 | Link to OMIM |
| Glomerulopathy with fibronectin deposits 2 | OMIM:601894 | Link to OMIM |
Related Interactions:
Notes: You can browse the related interactions in RNAinter by click the above link (since the interaction entries are too much to show here).