Basic information:

Untranslated mRNA: Sponge mRNA

Related IDs	cncRNA ID	CNC_M_001944
	Name	COL1A1
	Gene ID	1277
Location	Coordinate(Strand)	17:50184101-50201632(-)
Locus Sequence
Organism	Homo sapiens

Evidence support:

  

In vivo/vitro assay	In vitro assay and in vivo assay (Mouse)
Low-throughput method	Transfection assay;Western blotting;qRT-PCR;Luciferase assay;siRNA;Cell detachment;Cell migration assay;Cell invasion assay;Tumor formation assay;Immunohistochemistry
High-throughput method	/
Tissue/Cell	MDA-MB-231 cell
Description of experimental evidence	The mRNA was detected by transfection assay, western blotting, qRT-PCR, luciferase assay and siRNA in MDA-MB-231 cell, which can induce metastasis by regulating extracellular matrix functions

Orthologues:

  

Chimpanzee	ENSPTRG00000009393
Mouse	ENSMUSG00000001506
Drosophila	/
Zebrafish	ENSDARG00000012405   ENSDARG00000035809   ENSDARG00000035809

References:

  

PMID	22637644
Description	Protein analysis demonstrated that expression of CD44, Col1A1 and FN1 were synergistically upregulated in vitro and in vivo upon transfection of the CD44 3' UTR. The non-coding 3' UTR of CD44 interacts with multiple miRNAs that target extracellular matrix properties and thus can be used to antagonize miRNA activities.

Related Subcelluar Localization:

  

Subcelluar Localization	RLID	Link to RNALocate
nucleus	RLID00042744	Link to RNALocate
exosome	RLID00042745	Link to RNALocate

Related Diseases:

  

OMIM Phenotype	Phenotype MIM number	Link to OMIM
Caffey disease	OMIM:114000	Link to OMIM
Osteogenesis imperfecta, type I	OMIM:166200	Link to OMIM
Osteogenesis imperfecta, type II	OMIM:166210	Link to OMIM
Osteogenesis imperfecta, type IV	OMIM:166220	Link to OMIM
Bone mineral density variation QTL, osteoporosis	OMIM:166710	Link to OMIM
Osteogenesis imperfecta, type III	OMIM:259420	Link to OMIM
Ehlers-Danlos syndrome, arthrochalasia type, 1	OMIM:130060	Link to OMIM

Related Interactions:

  

  

   Notes: You can browse the related interactions in RNAinter by click the above link (since the interaction entries are too much to show here).