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Detail Information
Basic information:
Untranslated mRNA: Sponge mRNA
| Related IDs | cncRNA ID | CNC_M_001926 | |
|---|---|---|---|
| Name | ANGPT2 | ||
| Gene ID | 285 | ||
| Location | Coordinate(Strand) | 8:6499632-6563409(-) | |
| Locus Sequence | |||
| Organism | Homo sapiens | ||
Evidence support:
| In vivo/vitro assay | In vitro assay | |
|---|---|---|
| Low-throughput method | Transfection assay;Western blotting;qRT-PCR;Luciferase assay;Intraocular injection of miRNA mimic | |
| High-throughput method | / | |
| Tissue/Cell | RF/6A cell | |
| Description of experimental evidence | The mRNA was detected by transfection assay, western blotting, qRT-PCR, luciferase assay, intraocular injection of miRNA mimic in RF/6A cell, which can induce hypoxia-induced microvascular dysfunction by binding miR-351, acting as a decoy for VEGF-targeting microRNAs. | |
Orthologues:
| Chimpanzee | ENSPTRG00000019947 |
|---|---|
| Mouse | ENSMUSG00000031465 |
| Drosophila | / |
| Zebrafish | ENSDARG00000014946 |
References:
| PMID | 25172656 |
|---|---|
| Description | Bioinformatics prediction and 3'-UTR luciferase assay revealed that Ang-2 and VEGF is commonly targeted by miR-351. miRNA-dependent crosstalk between Ang-2 and VEGF plays a role in hypoxia-induced microvascular response. |
Related Subcelluar Localization:
| Subcelluar Localization | RLID | Link to RNALocate |
|---|---|---|
| Nucleus | RLID00039171 | Link to RNALocate |
| chromatin | RLID00073395 | Link to RNALocate |
| nucleoplasm | RLID00073396 | Link to RNALocate |
| nucleus | RLID00073397 | Link to RNALocate |
| exosome | RLID00073398 | Link to RNALocate |
| Cytosol | RLID00009526 | Link to RNALocate |
Related Interactions:
Notes: You can browse the related interactions in RNAinter by click the above link (since the interaction entries are too much to show here).