Basic information:

Untranslated mRNA: Scaffold mRNA

Related IDs	cncRNA ID	CNC_M_003827
	Name	Tusc2
	Gene ID	80385
Location	Coordinate(Strand)	9:107563255-107566112(+)
Locus Sequence
Organism	Mus musculus

Evidence support:

  

In vivo/vitro assay	In vitro assay
Low-throughput method	/
High-throughput method	RIP-seq
Tissue/Cell	Embryonic stem cell (ES cell)
Description of experimental evidence	The mRNA was detected by RIP-seq in ES cell, which can interact with EZH2 in PRC2 complex.

Orthologues:

  

Human	ENSG00000114383
Chimpanzee	ENSPTRG00000050779
Drosophila	/
Zebrafish	ENSDARG00000099817   ENSDARG00000025340

References:

  

PMID

21172659

Description

Here we develop a RIP-seq method to capture the PRC2 transcriptome and identify a genome-wide pool of 9000 PRC2-interacting RNAs in embryonic stem cells. A large number of transcripts occur within imprinted regions, oncogene and tumor suppressor loci, and stem cell-related bivalent domains. We provide evidence for direct RNA-protein interactions, most likely via the Ezh2 subunit. We also identify Gtl2 RNA as a PRC2 cofactor that directs PRC2 to the reciprocally imprinted Dlk1 coding gene. The data were collected from Supplementary tables.

Related Subcelluar Localization:

  

Subcelluar Localization	RLID	Link to RNALocate
Cytoplasm	RLID00022913	Link to RNALocate

Related Interactions:

  

  

   Notes: You can browse the related interactions in RNAinter by click the above link (since the interaction entries are too much to show here).