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Detail Information
Basic information:
Untranslated mRNA: Scaffold mRNA
| Related IDs | cncRNA ID | CNC_M_001834 | |
|---|---|---|---|
| Name | SMYD3 | ||
| Gene ID | 64754 | ||
| Location | Coordinate(Strand) | 1:245749342-246507312(-) | |
| Locus Sequence | |||
| Organism | Homo sapiens | ||
Evidence support:
| In vivo/vitro assay | In vitro assay and in vivo assay (Mouse) | |
|---|---|---|
| Low-throughput method | RNA affinity purification;Transfection assay;Knockdown | |
| High-throughput method | iCLIP-seq | |
| Tissue/Cell | HCT-116 cell | |
| Description of experimental evidence | The mRNA was detected by iCLIP-seq and transfection assay in HCT-116 cell, which can interact with EZH2. | |
Orthologues:
| Chimpanzee | ENSPTRG00000002187 |
|---|---|
| Mouse | ENSMUSG00000055067 |
| Drosophila | FBgn0036282 FBgn0033427 FBgn0028862 FBgn0011566 FBgn0038470 FBgn0053548 FBgn0030102 FBgn0033061 |
| Zebrafish | ENSDARG00000058050 |
References:
| PMID | 22659877 |
|---|---|
| Description | Here we use an in vivo cross-linking method to detect and identify direct PRC2-RNA interactions in human cancer cells, revealing a number of intronic RNA sequences capable of binding to the core component EZH2 and regulating the transcriptional output of its genomic counterpart. Overexpression of EZH2-bound intronic RNA for the H3K4 methyltransferase gene SMYD3 is concomitant with an increase in EZH2 occupancy throughout the corresponding genomic fragment and is sufficient to reduce levels of the endogenous transcript and protein, resulting in reduced growth capability in cell culture and animal models. |
Related Subcelluar Localization:
| Subcelluar Localization | RLID | Link to RNALocate |
|---|---|---|
| Nucleus | RLID00040328 | Link to RNALocate |
| Cytoplasm | RLID00040329 | Link to RNALocate |
| chromatin | RLID00098372 | Link to RNALocate |
| cytosol | RLID00098373 | Link to RNALocate |
| cytosol | RLID00098374 | Link to RNALocate |
| insoluble cytoplasm | RLID00098375 | Link to RNALocate |
| membrane | RLID00098376 | Link to RNALocate |
| membrane | RLID00098377 | Link to RNALocate |
| nucleolus | RLID00098378 | Link to RNALocate |
| nucleoplasm | RLID00098379 | Link to RNALocate |
| nucleus | RLID00098380 | Link to RNALocate |
| nucleus | RLID00098381 | Link to RNALocate |
| nucleus | RLID00098382 | Link to RNALocate |
| exosome | RLID00098383 | Link to RNALocate |
Related Interactions:
Notes: You can browse the related interactions in RNAinter by click the above link (since the interaction entries are too much to show here).