Basic information:

Untranslated mRNA: Scaffold mRNA

Related IDs	cncRNA ID	CNC_M_001802
	Name	POLR2A
	Gene ID	5430
Location	Coordinate(Strand)	17:7484366-7514614(+)
Locus Sequence
Organism	Homo sapiens

Evidence support:

  

In vivo/vitro assay	In vitro assay
Low-throughput method	Transfection assay;Immunofluorescence;RNA fish
High-throughput method	/
Tissue/Cell	Hela cell
Description of experimental evidence	The mRNA was detected by transfection assay, immunofluorescence and RNA fish in Hela cell, which can function as a scaffold in the formation of major nuclear bodies.

Orthologues:

  

Chimpanzee	/
Mouse	/
Drosophila	/
Zebrafish	/

References:

  

PMID	21240286
Description	Here we show that RNA can function as a structural element and a nucleator of nuclear bodies. We find that several types of coding and noncoding RNAs are sufficient to de novo assemble, and are physiologically enriched in, histone locus bodies (with associated Cajal bodies), nuclear speckles, paraspeckles and nuclear stress bodies.

Related Subcelluar Localization:

  

Subcelluar Localization	RLID	Link to RNALocate
chromatin	RLID00086479	Link to RNALocate
cytosol	RLID00086480	Link to RNALocate
cytosol	RLID00086481	Link to RNALocate
membrane	RLID00086482	Link to RNALocate
nucleolus	RLID00086483	Link to RNALocate
nucleoplasm	RLID00086484	Link to RNALocate
nucleus	RLID00086485	Link to RNALocate
nucleus	RLID00086486	Link to RNALocate
nucleus	RLID00086487	Link to RNALocate
exosome	RLID00086488	Link to RNALocate
Nucleus	RLID00015386	Link to RNALocate
Cytosol	RLID00015387	Link to RNALocate

Related Diseases:

  

OMIM Phenotype	Phenotype MIM number	Link to OMIM
Neurodevelopmental disorder with hypotonia and variable intellectual and behavioral abnormalities	OMIM:618603	Link to OMIM

Related Interactions:

  

  

   Notes: You can browse the related interactions in RNAinter by click the above link (since the interaction entries are too much to show here).